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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 4 (2013) - Issue 2, February

Review Articles

 
Title
Views
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1.

AN OVERVIEW OF PLANTS CAUSING TERATOGENICITY: FENUGREEK (TRIGONELLA FOENUM GRAECUM)

Some plants are toxic to living beings including humans, and are widely used all over the world in the treatment of various types of body ailments in traditional medicine, especially in the developing countries, due to theirs economic, social and cultural conditions. These plants are routinely taken for the nourishment of the pregnant women. This may cause the toxicity to the developing foetus, kn...

L.M. Taloubi*, H. Rhouda, A. Belahcen , N. Smires , A. Thimou and Alaoui A. Mdaghri

Teratovigilance Research Group, Faculty of Medicine and Pharmacy, Mohamed V. University , Souissi, Rabat, Morocco

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).516-19

516-519

2814

957

2.

A REVIEW OF NATURAL STEROIDS AND THEIR APPLICATIONS

Natural steroids, the simple mention of the word brings up topics like cheating, unfair advantages. The first misconception is that all steroids are used for muscle building. This is not at all the case, steroids are natural substances with many different effects in the human body, which begin over several days, as even birth control pills are a form of steroids. “Natural Steroids”, are the or...

Anas Rasheed* and Mohd. Qasim

Active Pharma Labs, Raja Enclave, # 404, Bhagyanagar Colony, Opp: R.S. Brothers, Beside K.S. Baker’s, K.P.H.B. Colony, Hyderabad-72, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).520-31

520-531

4355

571

3.

ACE INHIBITORS: A COMPREHENSIVE REVIEW

Hypertension is a chronic increase in blood pressure, characterized as primary and secondary hypertension. The disorder is associated with various risk factors like obesity, diabetes, age, lack of exercise etc. Hypertension is being treated since ancient times by Ayurvedic, Chinese and Unani medicine. Now various allopathic drugs are available which include diuretics, calcium channel blockers, α-...

Pradeep Kumar Arora* and Ashish Chauhan

Department of Pharmacy, Lovely Professional University, Phagwara, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).532-49

532-549

2237

1881

4.

NIOSOMES: A ROLE IN TARGETED DRUG DELIVERY SYSTEM

Niosomes are non-ionic surfactant vesicles inclosing an aqueous phase and a wide range of molecules could be encapsulated within aqueous spaces of lipid membrane vesicles. They are microscopic lamellar structures formed on the admixture of a non-ionic surfactant, cholesterol and phosphate with subsequent hydration in aqueous media. Niosomes belongs to novel drug delivery system which offers a larg...

Soumya Singh

Department of Pharmaceutics, Jaipur College of Pharmacy, ISI-15, RIICO Institutional Area, Sitapura, Tonk Road, Jaipur (Rajasthan)-302022, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).550-57

550-557

1791

600

5.

GENE THERAPY, RECENT DEVELOPMENT AND FUTURE PROSPECTS IN GASTROINTESTINAL ONCOLOGY: A REVIEW ARTICLE

The introduction of nucleic acids into cells has as a purpose of medical condition or disease. Currently, gene therapy studies a broad range of potential therapeutic interventions, including the body's immune reaction to tumours, new blood vessels in the heart to alleviate heart attacks and to stop HIV-replication in patients with AIDS1 .There is also renewed emphasis on the gene therapy of geneti...

Kotla Ramya Sree and Mudavath Hanumanaik

Department of Pharmaceutical Chemistry KLE University College of Pharmacy, Vidyanagar, Hubli, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).558-74

558-574

1413

469

6.

GREEN PHARMACY: AN ALTERNATIVE AND COMPLEMENTARY MEDICINE

The people in India have an outstanding knowledge of medicinal plants acquired over centuries.A passion for studying medicinal plants is evident both in folk and scholarly traditions. The indigenous mode of understanding and using plants is different from the modern scientific way. It includes botanical, medical and astrological elements. This is the basis of green pharmacy. Indians obviously care...

Neeta Shivakumar*, Pushpa Agrawal and Praveen Kumar Gupta

Department of Biotechnology, R V College of Engineering, Mysore Road, Bangalore-560 059, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).575-81

575-581

1351

582

7.

CRATAEVA TAPIA LINN. – AN IMPORTANT MEDICINAL PLANT: A REVIEW OF ITS TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES

Medicinal plants, since times immemorial, have been used in virtually all cultures as a source of medicine. Interest in herbal drugs is growing due to their efficiency, low toxicity and absence/minimal side effects. Crataeva tapia L. (Family-Capparaceae) is a branched tree, commonly called as ‘Varuna’. The plant has been reported to possess several medicinal uses which include anti-inflammator...

Priyanka Sharma*, Darshana Patil and Avinash Patil

Research Scholar, Department of Botany- Herbal Sciences, Birla College, Kalyan- 421304, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).582-89

582-589

2070

835

8.

CARDIOPROTECTIVE EFFECTS OF PHYTOSTEROLS

Foods and nutrients play a vital role in normal functioning of the body. They are helpful in maintaining the health of the individual and in reducing the risk of various diseases. Worldwide acceptance of this fact formed a recognition link between "nutrition" and "health" and the concept of "nutraceuticals" has evolved. More than any other disease, the etiology of cardiovascular disease reveals ma...

Jyotika Dhankhar

Department of Food Technology, M. D. U., Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).590-96

590-596

1638

421

9.

IN SITU GEL FORMING INJECTABLE DRUG DELIVERY SYSTEM

Recently, controlled and sustained drug delivery has become the standard in modern pharmaceutical design and an intensive research have been undertaken in achieving much better drug product effectiveness, reliability and safety. This interest has been sparked by the advantages shown by in situ gelforming drug delivery systems such as ease of administration and reduced frequency of administration, ...

Amruta B. Kumbhar*, Ashwini K. Rakde, P.D. Chaudhari

P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).597-09

597-609

3354

1200

10.

ANXIETY AND DEPRESSION: ADVANCES IN MANAGEMENT OF DISORDER

Anxiety and depression is basically a disorder of the present modern world and its prevalence is seen increasing day by day. According to WHO, anxiety and depression will be the second largest cause of disability worldwide by year 2020. The major problem associated with this disorder is that common masses are unaware about this disorder and hence less than 25% of those affected have access to appr...

Aakruti Kaikini*, Swati Dhande, Kalpana Patil and Vilasrao Kadam

Bharati Vidyapeeth’s College of Pharmacy, Sector-8, C.B.D. Belapur, Navi Mumbai-400614, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).610-16

610-616

1349

542

Research Articles

 
Title
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Cited
11.

FORMULATION AND EVALUATION OF NATURAL PALM OIL BASED DICLOFENAC SODIUM SUPPOSITORIES

The aim of the study was to formulate and evaluate natural palm oil based Diclofenac sodium suppositories. The formulated natural palm oil based suppositories were compared with suppositories of water soluble bases (PEG 4000 and 6000) and lipid soluble base (cocoa butter). The in-vitro drug release rate studies were carried out by using dissolution apparatus. The in-vitro release pattern of diclof...

S. Pugunes and R.E. Ugandar*

Lecturer, Faculty of Pharmacy.Staff ID:F 165, Asia Metropolitan University, (Formerly known as Masterskill University College of Health Sciences), G-8, Jalan Kemacahaya, Taman Kemacahaya, Batu-9,Cheras – 43200, Selangor, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).617-21

617-621

2426

972

12.

DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR IN-VIVO STUDY OF DICLOFENAC POTASSIUM

A High Performance Liquid Chromatographic method was developed for determination of Diclofenac Potassium in in-vivo study during bioavailability study. The chromatographic separation was conducted on Shimadzu Prominence LC 20 connected with PDA detector; using mixed column ODS/Cyano; ACE, (100 x 4.6 mm, 5 µm). The mobile phase was isocratic consisted of Methanol: 50 mM potassium dihydrogen phosph...

Mohamed Aly Abd El Aziz Aly El Degwy*, Mohamed Aly Mahmoud Aly and Mamdouh Salah El Den

Mepaco Pharmaceutical Company, 141 Street Ahmed Zaki, Maadi, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).622-27

622-627

1414

433

13.

A BROAD SURVEY AND COMPREHENSIVE STUDY ON UTILIZATION PATTERN OF ANTIBIOTICS IN TERTIARY CARE TEACHING HOSPITAL IN NORTH KARNATAKA

An ongoing, systematic process designed to maintain the appropriate and effective use of drugs is Drug Use Evaluation (DUE). It involves a comprehensive review of patient’s prescription and medication data before, during, and after dispensing in order to assure appropriate therapeutic decision making and positive patient outcomes. The aim of the present study is to conduct a prospective study o...

Ashok Kumar Malpani*, Nimmy N. John, V.L. Srividya, Y. Santoshi and Samrat Paul

Department of Pharmacy Practice, N.E.T. Pharmacy College, Mantralyam Road, Raichur- 584 101, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).628-32

628-632

1175

344

14.

DESIGN AND EVALUATION OF COST EFFECTIVE CONVENTIONAL TABLETS FROM MONECHMA CILIATUM SEEDS EXTRACT

The use of medicinal plants as raw material in the production of drugs is again gaining popularity. Monechma ciliatum has many traditional uses and applications in African folk’s medicines, e.g. the seed's powder macerated in water and drunk or burnt as an inhalation for treatment cold and allergic conditions. The aim of this study is to formulate a suitable dosage form (tablets) from Monechma c...

M.A.M. Oshi* and A.M. Abdelkareem

Department of Pharmaceutical Technology, Faculty of Pharmacy, Omdurman Islamic University, Omdurman, Sudan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).634-43

634-643

1603

407

15.

MICROWAVES ASSISTANT TECHNIQUE IN SPECTROPHOTOMETRIC ASSAY OF ISONIAZID USING IT’S SCHIFF’S BASE DERIVATIVES

Tuberculosis is an infection bacterial disease caused by Mycobactrium tuberculosis, which most commonly affects the lung, it can be treated with Anti-TB drug which are classified into first and second line drug classes where the treatment regimen consists of two phases: the initial phase and the continuation phase. Isoniazid is one of the most important first line drugs for the treatment of tuberc...

Arwa M. Elhagi, Nour Alhuda R. Ben Naji, Salah M. Bensaber, Tariq K. Almog*

Department of Medicinal and Pharmaceutical chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli-Libya

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).644-49

644-649

1764

840

16.

DETERMINANTS OF BREAST FEEDING PRACTICES AMONG MOTHERS ATTENDING PUBLIC HEALTH FACILITIES, MEKELLE, NORTHERN ETHIOPIA; A CROSS SECTIONAL STUDY

Background- Breastfeeding and good nutrition for children are essential for achieving the Millennium Development Goals, particularly the goals relating to child survival. Even though, most mothers in Ethiopia breastfeed their babies, they do not always follow the recommendations of the "National Strategy for Infant and Young Child Feeding". Objective- The aim of this study was to assess determi...

Hailemariam Berhe*, Bazie Mekonnen , Alemayehu Bayray and Haftu Berhe

Department of Nursing, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).650-60

650-660

2212

797

17.

THE EFFECT OF AVOCADO (PERSEA AMERICANA MILL.) LEAVES EXTRACT TOWARDS THE MOUSE’S BLOOD GLUCOSE DECREASE WITH THE GLUCOSE TOLERANCE METHOD

Decrease in blood glucose level test with the use of oral glucose tolerance method from Avocado leaves was carried out. Swiss Webster male mice were divided randomly into five groups. They were negative control, positive control (Glipizide 0.013 mg/20 g BW) and three test groups treated with dosage of avocado leaves ethanol extract 0.490 g/kg, 0.980 g/kg and 1.960 g /BW respectively. Experiment wa...

Shirly Kumala*, Hesty Utami* and Wahyu Kartika Sari

Pharmacy Faculty, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta, Indonesia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).661-65

661-665

2080

1600

18.

EFFECTS OF CAPSAICIN ON RAT SCIATIC NERVE IN VINCRISTINE-INDUCED NEUROPATHIC PAIN MODEL

Capsaicin, the pungent ingredient of red pepper, is used topically to treat different types of neuropathic pain, in rat model of vincristine induced neuropathic pain we tried to investigate the effect of capsaicin on sciatic nerve through electrophysiological and histopathological studies. We found that treatment of animals with vincristine results in significant decrease in sciatic nerve conducti...

Thanaa A. El-Masry *, Magda E. El Sayaad , Ibrahim A. Gaaboub and Wafaa M. Fouda

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).666-70

666-670

1547

379

19.

ICH GUIDANCE IN PRACTICE: DEVELOPMENT OF A VALIDATED STABILITY-INDICATING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY METHOD FOR FEBUXOSTAT AND DEGRADATION KINETIC STUDY IN ACID HYDROLYTIC CONDITION

The degradation behavior of Febuxostat was investigated under different stress degradation (hydrolytic, oxidative, photolytic and thermal) conditions recommended by International Conference on Harmonization (ICH) using HPLC and LCMS. Febuxostat was found to degrade significantly in acidic and alkaline conditions as well as in neutral hydrolysis. The drug was stable to dry heat, photolytic degrada...

Megha V. Sheth* and Jigar J. Pandya

Pharmaceutical Analysis and Quality Assurance Department, K.B. Raval College of Pharmacy, at Shertha, Post. Kasturinagar, Ta. & Dist. Gandhinagar-382423, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).671-81

671-681

1653

860

20.

ANTIDIARRHEAL ACTIVITY OF DILLENIA INDICA BARK EXTRACT M. Monirul Islam*1, Rashna Sharmin Pia 1, Kazi Sifath-E-Jahan 1, Jesmin Chowdhury 2, Fahima Akter 3, Nahida Parvin 1 and Sharmin Akter 1 Department of Pharmacy, Atish Dipankar University of Science & Technology 1, Dhaka, Bangladesh Department of Pharmacy, North South University 2, Dhaka, Bangladesh Department of Medical Science, National Institute of information Technology 3, Dhaka, Bangladesh

The present study was designed to investigate the antidiarrheal potential of the methanolic extract of Dillenia indica bark (MDIB). The extract studied for antidiarrheal property using castor oil and magnesium sulphate induced diarrheal model and charcoal induced gastrointestinal motility as well as PGE2-induced enterolooping test in mice. In addition, activities against some causative diarrheal p...

M. Monirul Islam*, Rashna Sharmin Pia , Kazi Sifath-E-Jahan , Jesmin Chowdhury , Fahima Akter , Nahida Parvin and Sharmin Akter

Department of Pharmacy, Atish Dipankar University of Science & Technology, House# 83, Road#4, Banani, Dhaka – 1213, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).682-88

682-688

1453

433

21.

FORMULATION DEVELOPMENT AND EVALUATION OF SOL TO GEL OCULAR DRUG DELIVERY SYSTEM OF BRIMONIDINE FOR CONJUNCTIVITIS

The purpose of the present research work was to develop ophthalmic sol to gel controlled delivery system of brimonidine, for the treatment of bacterial conjunctivitis having improved patient compliance and better therapeutic efficacy. For that purpose various formulations were prepared and evaluated for their quality parameters i.e. rheological, trans-corneal permeation, ocular irritation studies,...

Manu Babbar*, Kanchan Kohli and Anil Bhandari

Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur-342001, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).689-93

689-693

1555

461

22.

FATTY ACID COMPOSITION OF SOME LEAFY VEGETABLES OF BANGLADESH

Fatty acid composition of six different leafy vegetables of Bangladesh was investigated. The amount of bound fatty acids was found to be higher than the free fatty acids in all the leafy vegetables. Different fatty acids were identified and their relative proportions were determined by GLC from the leafy vegetables.  ...

Kamal Karmakar, Tanvir Muslim* and Md. Azizur Rahman

Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).694-97

694-697

1333

449

23.

RADICAL SCAVENGING POTENTIAL OF CLEOME VISCOSA L. AND CLEOME BURMANNI W. & A. (CLEOMACEAE)

The present study evaluates the reactive oxygen species (ROS) scavenging and in vitro antioxidant activities of two species of Cleome, C. viscosa and C. burmanni. The antioxidant potential of the methanol extracts of species of Cleome was tested using different assays such as FRAP, DPPH, ABTS, hydroxyl, superoxide, nitric oxide, and hydrogen peroxide. The extracts gave positive results for all the...

Lakshmi S. Pillai* and Bindu R. Nair

Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram- 695 581, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).698-05

698-705

1375

453

24.

FORMULATION AND EVALUATION OF CHITOSAN BASED BUCCAL PATCH OF GRANISETRON HYDROCHLORIDE

Granisetron  hydrochloride  is  most  commonly  used  as  an  antiemetic  agent  in  treatment  associated  with  cancer  chemotherapy  induced  nausea  and  vomiting.  If  the  dosage  form  is  designed  in  sustain  release  it  provide  more  advantage  for  the  antiemetic  therapy.  The  purpose  of  this  research  was  to  study  mucoadhesive  ...

P.K. Khobragade*, P.K. Puranik, S.D. Pol, R.G. Palasakar and B.A. Patil

Pharmaceutics Department, Government College of Pharmacy, Vedant Road, Osmanpura Aurangabad- 431005, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).706-16

706-716

1796

526

25.

IN VITRO ANTIOXIDANT ACTIVITY OF CURCUMA AMADA ROXB.

A study was undertaken to evaluate the antioxidant potential of rhizomes of Curcuma amada (Zingiberaceae). Aqueous and ethanolic extracts were subjected to in vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and inhibition of lipid peroxidation activity. Ascorbic acid was used as the standard.  In all the models studied, both the extracts showed nearly equal activities...

Sanjay Jain, Rakesh Barik* and Arti Jain

Department of Pharmacognosy, Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).717-20

717-720

1394

554

26.

ANTI-INFLAMMATORY ACTIVITY OF SAMADERA INDICA LEAVES BY MEMBRANE STABILIZATION

The present work aims at evaluating the anti-inflammatory activity of Samadera indica by HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The anti-inflammatory activity of the crude ethanol extract, aqueous extract of leaves part of Samadera indica were compared to that of the standard drug diclofenac....

G.R. Rajalakshmi* and Jyoti Harindran

Research Scholar, Karpagam University, Karpagam, Coimbatore, Tamil Nadu-641021, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).721-23

721-723

1352

531

27.

DEVELOPMENT AND IN VITRO EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF VERAPAMIL HCl

Gastro retentive controlled release drug delivery system of Verapamil HCl was formulated to increase the gastric retention time of the dosage form with controlling the drug release pattern. Different grades of hydroxy propyl methyl cellulose derivatives; Methocel K4M and Methocel K15MCR were incorporated for their gel forming properties. Tablet buoyancy was achieved by incorporating a mixture of g...

Syeda Amina Toufique , Md. Abdullah Al Masum , Florida Sharmin, Sabiha Sultana , Md. Selim Reza and Mohiuddin Ahmed Bhuiyan *

Professor & Head, Department of Pharmacy, University of Asia Pacific, House # 73, Road #, 5A, Dhanmondi, Dhaka-1209, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).724-30

724-730

1349

431

28.

COMPARISON OF EFFICACY OF FIVE VARIOUS COMMERCIAL PRODUCTS OF CIPROFLOXACIN AGAINST STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA

A study was undertaken to evaluate the efficacy of five various commercial products of ciprofloxacin (a broad spectrum antibiotic), manufactured by different pharmaceutical companies. The drug was evaluated for their performance based on equivalent MIC breakpoint, which is a measure of efficacy of drugs against Staphylococcus aureus ATCC6538 and Pseuomanas aeruginosa ATCC25668 when tested in vitro...

Vivek Kumar Shrivastav 1, Deepali Shukla ,Ashamukul Jana and Archana Shrivastav*

Professor and Head, Department Of Microbiology, College of Life Sciences, Cancer Hospital & Research Institute Campus, Mandre Ki Mata, Gwalior- 474009, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).731-33

731-733

1120

374

29.

CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF HARAMAYA PROPOLIS (BEE GLUE), ETHIOPIA

The present study was aimed at investigating the chemical composition and antifungal activity of Ethanol Extracted Haramaya propolis (EEHP). The GC-MS analysis of EEHP showed the presence of sixteen compounds and twelve compounds were identified by means of their retention times, by comparison of their mass spectra with the NIST 2005 library data and literature. The major constituents of EEHP were...

Kesatebrhan Haile*and Aman Dekebo

Department of Chemistry, Haramaya University, P.O. Box: 138, Haramaya, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).734-40

734-740

1493

540

30.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR ESTIMATION OF DICLOFENAC SODIUM IN SWAB SAMPLES

The objective of the current study was to develop and validate simple and precise UV Spectrophotometric method for estimation of Diclofenac Sodium in the swab samples to validate cleaning procedure. The swabbing procedure was optimized in order to obtain a suitable recovery from stainless steel surface using Tex wipe polyurethane swab stick. Detection wavelength selected was 267 nm. The proposed m...

P.P. Goti, J.J. Savsani and P.B. Patel

Department of Quality Assurance, S. J. Thakkar Pharmacy College, Rajkot, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).741-44

741-744

2895

795

31.

ANTIMICROBIAL, CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF THE EXUDATE OF CALOTROPIS GIGANTEA

Plant is one of the important source of drugs that’s why we have done this project work to find out some biological activities of the plant exudates of Calotropis gigantea where antimicrobial, cytotoxic and antioxidant activity were analyzed. To test of antimicrobial activity, disc diffusion method has been followed. The exudate of the plant has shown antimicrobial activity against four microorg...

Md. Shafikur Rahman*, Naznin Nahar Moly and Md. Jahid Hossen

Department of Pharmacy, Southeast University, PO Box: 1213, Banani, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).745-53

745-753

1728

589

32.

PASSION FRUIT: A FETCHED PASSION FOR DENTISTS

Objective: Dental caries is a common oral infection prevalent in developing countries. Streptococcus mutans, a commensal bacterium of the oral cavity, plays a major role in the etiology of caries and root canal infection. Sodium hypochlorite and Chlorhexidine are used in the prevention of caries and as root canal medicament though they cannot be used in combination. Study Design: Different conc...

Smita Singh* and Debojyoti Das

Department of Conservative and Endodontics, Darshan Dental College and Hospital, Udaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).754-57

754-757

1410

634

33.

DEVELOPMENT OF A NOVEL ENTERIC COATED EXTENDED RELEASE PELLETS USING MODEL NSAID FLURBIPROFEN

The aim of this study was to develop a pH responsive enteric coated extended release pellets containing a model drug flurbiprofen, a non-steroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets were prepared by using extrusion/ spheronization method. Core pellets were coated with polymer Eudragit RS30D in a coating pan to achieve a sustainable release for 12 hours. A...

V. Abhinetri, Mohd. Abdul Hadi*, A. Srinivasa Rao and Sravani V.

Department of Pharmaceutics, Bhaskar Pharmacy College, Yenkapally (V), Moinabad (M), R.R District, Hyderabad-500075, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).758-64

758-764

1571

488

34.

PREVALENCE OF DEPRESSION AND ASSOCIATED FACTORS AMONG PEOPLE LIVING WITH HIV/AIDS IN TIGRAY, NORTH ETHIOPIA: A CROSS SECTIONAL HOSPITAL BASED STUDY

Objective: The aim of this study was to determine the prevalence of depression and associated factors among people attending ART clinics in Tigray, Ethiopia. Method: Institution based cross-sectional study was conducted on patients attending ART clinics for persons living with HIV/AIDS (PLWHA) at Adigrat, Mekelle and Maichew Hospitals in Tigray region. Sample size was calculated using Epi info ...

Haftu Berhe* and Alemayehu Bayray

Department of Nursing, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).765-75

765-775

1627

1476

35.

SURVIVAL AND PREDICTORS OF MORTALITY AMONG PATIENTS UNDER MULTI-DRUG RESISTANT TUBERCULOSIS TREATMENT IN ETHIOPIA: ST. PETER’S SPECIALIZED TUBERCULOSIS HOSPITAL, ETHIOPIA

Background: Multi-drug resistance tuberculosis (MDR-TB) is an increasing global problem. The extent and burden of MDR-TB varies significantly from country to country. Survival of MDR-TB treatment is not described in Ethiopia. Therefore, examining a cohort who received second-line therapy for MDR-TB to determine overall survival has a great importance. Objectives: To assess survival and predicto...

Theodros Getachew, Alemayehu Bayray and Berhe Weldearegay

Ethiopian Health and Nutrition Research Institute (EHNRI), Mekelle University College of Health Science (MU, CHS), Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).776-87

776-787

1989

644

36.

IN-VITRO ANTIOXIDANT ACTIVITY OF THE SUCCESSIVE EXTRACTS OF ZIZIPHUS MAURITIANA LEAVES

The importance of medicinal plant has been emphasized from time to time. It is believed that the drug of natural origin shall play an important role in health care particularly in rural areas of India. Ziziphus mauritiana belongs to family Rhamnaceae and commonly known as Indian jujube or ber .The leaves are alternate and elliptic. Flowers are small and bisexual .The leaves are about 2.5 – 3.2 c...

M. K. Gupta and Ramesh Kumar Singh*

Department of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).788-91

788-791

1419

427

37.

PHARMACOGNOSTICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATION ON LEAVES OF TRIDAX PROCUMBENS LINN.

The study is aimed at development of physicochemical parameters and to investigate the active principle present in Tridax procumbens Linn. Tridax procumbens Linn. (Asteraceae) commonly known as Coat Buttons is an important plant used against various disorders in indigenous system of medicine such as Wound-Healing, Hepatoprotective, Anti-Inflammatory, Anti-diabetic and Immunomodulatory activities. ...

Sangeeta Kumari , Swati Jain , Rita Pal, Sumitra Nain* and Sarvesh Paliwal

Department of Pharmacy, Banasthali University, Banasthali Tonk- 304 022, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).792-95

792-795

1314

642

38.

ACUTE AND SUBACUTE TOXICITY STUDIES ON SHODHANA PROCESSED GUGGUL

Ayurveda– The science of life is known to the mankind since time immemorial. It prolongs life span, maintains positive health and cures diseases. Due to its high effectiveness, popularity and the socio-economic status it was recognized as an independent branch of learning and has been known as “Rasa Shastra” and “Rasa chikitsa” in the field of Ayurveda.  After the development of rasa Sh...

Poonam Taru, Mukta Abhyankar*, Vaishali Undale and Ashok Bhosale

Seth Govind Raghunath College of Pharmacy, Saswad, Pune, Mahrashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).796-99

796-799

1530

1091

39.

ISOLATION AND ANTIMICROBIAL AND DEGRADATIVE POTENTIAL OF ACTINOMYCETES

Problem Statement: Do the soil Actinomycetes do have Antimicrobial and Petrol degradation potential? An intriguing question. Actinomycetes are continues to be a subject of study with reference to their Antimicrobial and degradative potential. However studies have been done is limited. Our object was to study its Antimicrobial activity in wide spectrum and to study its degradation potential on Petr...

Padma Singh* and Vani Sharma

Department of Microbiology, Girls Campus Gurukul Kangri (Deemed University), Hardwar- 249 407, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).800-05

800-805

1557

388

40.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF PHENOBARBITONE AS BULK DRUG AND IN PHARMACEUTICAL FORMULATION

A sensitive, selective, precise and stability indicating high performance thin layer chromatographic method of analysis of Phenobarbitone both as a bulk drug and in formulations was developed and validated in pharmaceutical dosage form. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of dichloromethane: ethyl acetate:...

P.R. Mhatre*, S.H. Gatkal, V.V. Chopade and P.D. Chaudhari

Department of Quality Assuranse Techniques, Modern College of Pharmacy Nigdi, Pune-411044, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).806-12

806-812

1244

648

41.

APHRODISIAC ACTIVITY OF ETHANOL ROOT EXTRACT AND FRACTIONS OF LANDOLPHIA DULCIS (SABINE) PICHON

Background: Among the traditionally used sex enhancement natural remedies in south eastern Nigeria, L. dulcis root is very popular because of its quick onset of action. However, its use has not been scientifically validated. This study therefore investigated the effects of its ethanol extract and fractions on sexual behavior in male albino rats. Methods: Forty-five male albino rats were randoml...

E.E. Ilodigwe, E.N. Igbokwe, D.L. Ajaghaku and C.P. Ihekwereme

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Agulu Campus, Anambra state, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).813-18

813-818

1621

515

42.

BIOCHEMICAL ESTIMATION OF PRIMARY METABOLITES OF PHYLA NODIFLORA L. GREENE

Phyla nodiflora is an evergreen perennial herb found near the water bodies. It belongs to family Verbenaceae. It is commonly known as frog fruit or turkey tangle. The present investigation is the estimation of primary metabolite content in various plant parts. The investigation revealed that maximum amount of soluble sugar was found in stem, maximum amount of starch found in stems, leaves showed t...

Renu Singh* and R.A. Sharma

Plant Physiology and Biochemistry lab, Department of Botany, University of Rajasthan, Jaipur- 302 004, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).819-22

819-822

1341

491

43.

PHYTOCHEMICAL ANALYSIS AND ANTICANCER ACTIVITY OF LEAF EXTRACT OF MANGIFERA INDICA (KOTTUKONAM VARIKA)

About 6 extract (methanol, acetone, hexane, ethyl acetate, hexane-ethyl acetate, aqueous extraction) from the leaves of Mangifera indica was extracted. Hexane-ethyl acetate was characterized by Gas Chromatography- Mass Spectroscopy. Ten constituents from 10 peaks were identified. Terpinyl acetate (5.80%) and phytol isomer (5.12%) are as the major constituents and the minor constituents like oxira...

P.A. Mary Helen*, M.R. Aswathy, K.G. Deepthi, R. Rathi Mol, J. Jaison Joseph and S. Jaya Sree

Department of Biotechnology, Malankara Catholic College, Mariagiri, Kaliakkavilai – 629153, Kanyakumari District, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).823-28

823-828

4975

914

44.

SYNTHESIS AND DOCKING STUDIES OF 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDE DERIVATIVES

A  novel  N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-pipear azinyl]-2-methyl-4-pyrimidinyl] amino]-5-thiazolecarboxamide derivatives (6a-6d) and (8a-8b) were synthesized  by coupling 2-[(6-chloro-2-methylpyrimidin-4ylamino]-N-(2-chloro-6-methylphenyl) thiazole-5-Carboxamide(3) with Piperazine derivatives(4,7) in butanol and DIPEA (Diisopropylethylamine) at 120ºC for 4-5hrs. All th...

K. Hemalatha*, Nandakishore Agarwal and G. Buchappa

Pharmaceutical Chemistry Department, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).829-35

829-835

1594

498

45.

ANTIMICROBIAL AND ANTIOXIDANT SYNERGY OF PSORALEA CORYLIFOLIA LINN. AND PLUMBAGO ZEYLANICA LINN.

Objectives: Psoralea corylifolia L.(seeds) and Plumbago zeylanica L. (bark) were combined in the ratio of 8: 2 and named as “Swithranasini” and used for the treatment of skin diseases in ayurvedic medicine. Scientific studies validating the therapeutic properties for this indigenous medicine are lacking. This study focused on determining antimicrobial efficacy of methanol and butter milk ext...

P. Suman , P.V. Smitha , K.Y. Ramkumar , A. Siva , Ch. Murali Mohan and S. Hara Sreeramulu*

Head of the Department, Department of Biotechnology, Dr. V.S. Krishna Govt. PG College, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).836-42

836-842

1782

472

46.

A STUDY ON IN VITRO ANTIBACTERIAL ACTIVITY OF FICUS BENGALENSIS LINN. ON DENTAL CARIES PATHOGENS STREPTOCOCCUS MUTANS AND ACTINOMYCES VISCOSUS

The aerial roots of Ficus bengalensis Linn. were collected in and around Chennai, Tamilnadu, India  They were washed, shade dried and were ground into powder.  The powder was extracted with chloroform, petroleum ether, methanol and hexane. The antibacterial screening of the extracts was carried out by determining the zone of inhibition using disc diffusion method. The strains were grown to logar...

F. Michael Bernard Prashanth, I. Kannan*, Cecilia Sambandam, M. Jayalakshmi, R.K. Premavathy and S. Shantha

Department of Microbiology, Tagore Dental College and Hospital, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).843-46

843-846

1250

498

47.

A REVISED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF VILDAGLIPTIN AND PIOGLITAZONE HCl – APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS

A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-diabetic drugs. The separation was achieved on ACE 3 150mm*4.6mm, 3.5µm column with gradient flow. The mobile phase at a flow rate of 1.5 mL min−1 consisted of 10mM sodium hexane sulphonate monohydrate and 10mM Potassium dihydrogen phosphate buffer with acetonitrile an...

Hitesh P. Inamdar *, Ashok A. Mhaske , Shirish P. Sahastrabudhe

Research Officer, Getz Pharma Research Pvt. Ltd., , Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).847-55

847-855

1833

907

48.

ANTI – INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITY OF TWO SIDDHA FORMULATIONS IN COMBINATION

In Siddha system of medicine, the two formulations Vedikara silasathu parpam and Nerunjil kudineer in combination is given for urinary tract infection. Inhibition in the synthesis of inflammatory mediators and prostaglandins owe to the anti- inflammatory and antinociceptive properties of the drugs. In this study, the two Siddha formulations VSP and NK in combination was evaluated for anti- inflamm...

B. Akila* and K. Manickavasakam

Department of Maruthuvam, National Institute of Siddha, Chennai-47, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).856-61

856-861

1964

559

49.

SCREENING OF MURRAYA KOENIGII (CURRY) AND CAMELLIA SINENSIS (TEA) LEAVES FOR ANTIMICROBIAL ACTIVITY AGAINST STRAINS OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA SPECIES AND THEIR PHYTOCHEMICAL ANALYSIS

Antimicrobial activity of extracts leaves of Murraya koenigii (Curry) and Camellia sinensis (Tea) plants prepared in water, methanol and ethanol by cold maceration method were evaluated for their antimicrobial activity against Staphylococcus aureus (3) strains, Pseudomonas aeruginosa (3) and Candida species: Candida albicans (2 and one strain each of Candida tropicalis, and Candida parapsilosis. T...

Aarti Katoch, Bhanu Batta, Amit Kumar and P. C. Sharma

Shoolini University of Biotechnology and Management Sciences, Bhajol, Solan, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).862-68

862-868

1710

547

51.

COMPARATIVE ANTIOXIDANT ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF DIFFERENT PARTS OF THE PLANT- ACACIA AURICULIFORMIS

The present study was undertaken to evaluate and compare the antioxidant activity and brine shrimp lethality bioassay of different parts (leaf and bark) of the plant Acacia auriculiformis. DPPH radical scavenging and NO scavenging capacity were measured for the determination of antioxidant activity. Ethyl acetate fraction of bark was found to possess highest DPPH radical scavenging activity with I...

Kaniz Fatima Urmiz, Syeda Yeasmine Chowdhury , Md. Kamal Hossain , Prabhat Bhusal and Kaiser Hamid*

Lecturer, Department of Pharmacy, East West University, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).875-80

875-880

1244

339