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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 4 (2013) - Issue 12, December

Review Articles

 
Title
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1.

SELF EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

Solubility of orally administered drug is major challenge of pharmaceutical industry as nearly 35-40% of newly launched drugs possess low aqueous solubility which leads to their poor dissolution and low bioavailability, resulting in high intra & inter subject variability & lack of dose proportionality. This can be increased by different methods like salt formation, solid dispersion and com...

Kshitija Khedekar* and Swati Mittal

Department of Quality Assurance, Vivekanand Education Society’s College of Pharmacy, Chembur, Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4494-07

4494-4507

9708

1501

2.

AN OVERVIEW ON ARACHIS HYPOGAEA PLANT

The peanut or groundnut (Arachis hypogaea) is a species in the legume family (Fabaceae). There are different varieties like Virgina group, Spanish group, Runner group, Valencia group, Tennessee red and Tennessee white. Peanut consists of 30 essential nutrients and phytonutrients. Peanuts are a good source of vitamins & metals. Peanut hulls consist of crude fiber, cellulose, water, crude protei...

Karra Geetha*, Nadenla Ramarao , R. Shireesh Kiran , K. Srilatha , P. Mamatha , V. Umamaheswar Rao

Assistant Professor, CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4508-18

4508-4518

6081

2239

3.

A REVIEW ON BETEL LEAF (PAN)

The World Health Organization adopted a major policy change in accepting that most developing nations would have to make use of more traditional medical practices for primary health care. Piper betel L.belongs to family Piperaceae commonly known as Pan. It is extensively grown in Sri Lanka, India, Thailand, Taiwan and other Southeast Asian countries. This oil may be used as an industrial raw mater...

Rupa Sengupta* and Jayanta K. Banik

Assistant Professor, Department of Pharmacognosy, ROFEL, Shri G.M. Bilakhia College of Pharmacy, Namdha Road, Vapi-396191 Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4519-24

4519-4524

9578

2262

4.

PAEDERIA FOETIDA LINN: PHYTOCHEMISTRY, PHARMACOLOGICAL AND TRADITIONAL USES

Paederia foetida (Skunk vine) an indigenous plant belongs to family Rubiaceae. The plant is having a broad spectrum of use as in treatment of ailments like hepatic disorders, rheumatoid arthritis, constipation, diabetes, coughs, asthma, itches, wounds, stomachache, diarrhoea, dysentery, pain, typhoid, pneumonia, toothache, cancer, flatulency, body ache, and bone fractures etc. Literature data reve...

Rajesh Kumar Soni*, Raghuveer Irchhaiya, Vihangesh Dixit and Shashi Alok

Research Scholar, Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4525-30

4525-4530

4174

1041

Research Articles

 
Title
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5.

DETERMINATION OF ISOSORBIDE MONONITRATE (ISMN) AND ITS TWO RELATED SUBSTANCES IN ISOSORBIDE MONONITRATE AND SODIUM CHLORIDE INJECTION

A high-performance liquid chromatography (HPLC) method has been developed for the determination of isosorbide mononitrate and its related substances in isosorbide mononitrate and sodium chloride injection. An C18 column (5μm, 250 ×4.6 mm) was used for the determination, with methanol and water (25:75,v/v)as the mobile phase at the flow rate of 1 mL min−1. The detection wavelength was 210 nm. T...

Liandong Hu *, Yanjing Shi and Na Gao

School of Pharmaceutical Sciences & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University. No.180, WuSi Road, Baoding, 071002 PR China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4531-36

4531-4536

2427

1174

6.

IN VITRO EVALUATION OF ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENT OF METHANOLIC EXTRACT OF PIPER BETEL

The Piper betel is an evergreen and perennial creeper belonging to the Piperaceae family, with glossy heart-shaped leaves and white catkin. It is valued both as a mild stimulant and for its medicinal properties. The total phenolic content of methanolic leaves extract was estimated by Folin-Ciocalteu assay method, and was found to be 0.110 mg/CE/g (Catechine Equivalent per gram). However, anti...

Balaji Kaveti*, Penny Tay Siaw Ying , Sajitha Parkunan , Sunitha Ganesan and Mirza Baig

Associate Professor, Unit of Pharmaceutical Chemistry, AIMST University, Semeling 08100, Kedah Darul Aman, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4537-41

4537-4541

1875

710

7.

EFFECT OF NANOCURCUMIN PARTICLES PREPARED BY TOP-DOWN METHOD ON CCl4-INDUCED HEPATIC FIBROSIS MICE

Curcumin, a hydrophobic polyphenolic compound derived from the rhizome of the herb Curcuma longa, possesses a wide range of biological applications including anti-cancer. Nanocurcumin particles were prepared by top-down method as its can improve hydrophilic and increase bioavailability. As a result, curcumin concentration was yielded up to 10% (w/w), and the particle size was defined less than 1,0...

Hoang L. Son*, Nguyen T.H. Trang , Do T. Sinh and Mai N.T. Anh

Head of Department of Applied Chemistry, School of Biotechnology, International University, Vietnam National University-Ho Chi Minh City, Room A501, Block 6, LinhTrung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4542-48

4542-4548

2296

826

8.

SUB-CHRONIC TOXICOLOGICAL INVESTIGATION OF GMELINA ARBOREA (VERBENACEAE) IN HEALTHY WISTAR RATS

The study was designed to determine the acute and sub-chronic toxic effects of aqueous extract of Gmelina arborea (Roxb.) in healthy male Wistar rats. An aqueous bark extract of G. arborea was administered at graded doses (0.25-2.00 g/kg) to Wistar rats in the acute toxicity test. Sub-chronic toxicity was evaluated by daily administration of the extract at 1.00 g/kg to Wistar rats for 30 days. All...

A. P. Attanayake*, K.A.P.W. Jayatilaka , C. Pathirana and L.K.B. Mudduwa

B. Sc. (Hons), Lecturer, Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Sri Lanka

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4549-54

4549-4554

1867

668

9.

FUNCTIONALIZATION OF THE SELECTED REGENERATED CELLULOSIC FABRICS WITH HERBAL OIL AND EVALUATE THE FUNCTIONAL PROPERTIES

In this study, an attempt has been made to approach of developing antibacterial finish using aromatic herbal oils. The five different herbal oils like Palmarosa, Petitgrain, Tea tree, Thyme, Lavender oil were screened with disc diffusion method against bacteria that normally exist like Staphylococcus aureus, Escherichia coli. The result showed good efficiency in Thyme oil when compared to other oi...

R. Geethadevi* and V. Maheshwari

PSG College of Arts and Science, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4555-58

4555-4558

1684

834

10.

PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF NOVEL FIBRINOLYTIC PROTEASE PRODUCED BY MESOPHILIC BACILLUS CIRCULANS GD25

A novel fibrinolytic protease from Bacillus circulansGD25 was isolated and characterized for the fibrinolytic activity. The fibrinolytic protease was purified by ammonium sulphate fractionation (70%) and subjected to chromatographic methods like Sephadex G-50, DEAE –Sephadex A-50 columns. The purified enzyme has an approximately 38 kDa in size by SDS-PAGE and gel filtration. Optimum activity was...

E. Venkata Naga Raju* and Divakar Goli

Department of Biotechnology & Microbiology, Acharya & B.M. Reddy College of Pharmacy, Soldevanahalli, Hesaraghatta, Bengaluru-560107, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4559-66

4559-4566

1788

623

11.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF RITONAVIR IN TABLET DOSAGE FORM

A simple, precise, accurate and repeatable method for bulk and tablet dosage form of Ritonavir have been developed using spectrophotometric method. Differential spectrophotometric method was used. The developed method was validated according to ICH (Q2R1) guidelines and was found to be accurate, precise and specific. Amplitude difference was taken at absorbance maxima at 246 nm and absorbance mini...

C.D. Trivedi*, R. B. Mardia, B.N. Suhagia and S.P. Chauhan

Faculty of Pharmacy Dharamsinh Desai University, Nadiad- 387001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4567-72

4567-4572

1989

578

12.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF CYTARABINE IN BULK AND PHARMACUTICAL DOSAGE FORMS

A simple, rapid, accurate, specific and sensitive reverse phase liquid chromatography method (RP-HPLC) was developed and validated for the estimation of Cytarabine in Pharmaceutical dosage form. The method was standardized using a Nova pack C18 column (250 mm x 4.6 mm ID; Particle size 3 μm) and the mobile phase consisted of acetonitrile: buffer (Ammonium acetate) at 30:70% v/v. The eluents were ...

Varanasi. S.N. Murthy*, A. Rohini , K.E. Pravallika , A. Prameela Rani and S.A. Rahaman

Research Scholar, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4573-76

4573-4576

2521

687

13.

ANTIMICROBIAL POTENTIAL OF EXTRACT FROM LEAVES OF KALANCHOE PINNATA

Herbal medicine refers to the use of any plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Kalanchoe pinnata is known as herbal medicine that having many special advantages. The objective of the study was to scientifically assess antimicrobial activity of 95% ethanolic, methanolic, 60% methanolic and aqueous extract of leaves from Kalanchoe pinnata on Staphylococcus a...

Seema V. Pattewar*, Deepak N. Patil, and S. B. Dahikar

Sanjivani Institute of Pharmacy and Research, Kopargaon-423601, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4577-80

4577-4580

4283

1220

14.

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF 18-Β-GLYCYRRHETIC ACID

An attempt was made to formulate and evaluate the 18-β-glycyrrhetic acid (GA) transdermal drug delivery system. Preformulation studies on the drug 18-β-glycyrrhetic acid were done which included description, solubility and compatibility studies. Solvent casting technique was used to prepare the transdermal patches. Four formulations were made with 400mg of 18-β-glycyrrhetic acid and by using po...

Prachi Patel* and V.H. Bhaskar

Department of Pharmacognosy, M.P. Patel College of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4581-86

4581-4586

3554

876

15.

HUMAN RED BLOOD CELL MEMBRANE STABILITY TESTING FOR THE ESTIMATION OF ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF MILLETTIA PACHYCARPA BENTH LEAVES

The present study is carried out with the methanolic extract of leaves of Millettia pachycarpa benth. Traditional use of it inspired us to investigate the blood corpuscular protective power of this plant as it used as blood tonic in Chinese traditional medicine. By the phytochemical screening we have both flavonoids and steroids. There’s also alkaloids are found which have extensive physiologic ...

Amin Chowdhury, Abdullah Al Mamun, Shadman Rahman, Shofiul Azam*, Kishower Shams and Abdullah Jainul

Department of Pharmacy, International Islamic University Chittagong, 154/A, College road, Chittagong-4203, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4587-90

4587-4590

3400

772

16.

EVALUATION OF LEONOTIS NEPETAEFOLIA FOR ITS PHYTOCHEMICAL AND HEAVY METAL ANALYSIS

Phytochemical, HPTLC and Heavy metal analysis of Leaf of Leonotis nepetaefolia was done. Qualitative phytochemical screening of Leaf was done using different solvents which showed the presence of various vital secondary metabolites. Neutraceutical studies revealed the presence of carbohydrates, proteins and aminoacids. HPTLC studies confirmed the presence of flavonoids, diterpene, phenolic class o...

M. Kamalam*, C. Saraswathi and U. Umadevi

PG and Research Department of Botany, PSGR Krishnammal College for women, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4591-96

4591-4596

1965

774

17.

FOLK USE AND ANTIOXIDANT POTENTIAL DETERMINATION OF ZANTHOXYLUM RHETSA DC. SHOOT-A HIGHLY UTILIZED HOT SPICE FOLK VEGETABLE OF ARUNACHAL PRADESH, INDIA

Zanthoxylum rhetsa DC. shoot is highly priced and one of the most preferred folk vegetable among the Indigenous people of Arunachal Pradesh, India. It is also used as folk medicinal purpose among the Adi tribe of the state. The methanol extract of shoot were evaluated for total phenolic content (Folin-Ciocalteu’s method), total flavonoid content (colorimetric method) and antioxidant potential ((...

Temin Payum*, A.K. Das , Rama Shankar , C. Tamuly and M. Hazarika

Department of Botany, J.N College , Pasighat, East Siang District, P.O. Hill Top - 791103, Arunachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4597-02

4597-4602

2479

1044

18.

SCREENING OF INDIGENOUS MEDICINAL PLANTS FOR THEIR ACARICIDAL ACTIVITY AGAINST CATTLE TICKS UNDER IN VITRO CONDITION

The aqueous and alcoholic leaf extracts of Annona squamosa, Azadirachta indica and Calotropis procera were tested against the cattle ticks.  The fresh and leaf powder extracts were tested individually and also in combinations under in vitro conditions. The extracts of A. indica showed maximum mortality rate of ticks followed by A. squamosa and C. procera when tested individually.  In combination...

V. Nithya , M. Kamalam*and T. Umakanthan

Department of Botany, PSGR Krishnammal College for Women, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4603-06

4603-4606

1949

807

19.

SYNTHESIS AND PHARMACOLOGICAL ACTIVITY EVALUATION OF OXADIAZOLES CONTAINING SUBSTITUTED DIHYDROPYRIMIDINONE AND CHLOROQUINOLINE MOITIES

In the present paper, synthesis of new series of 1,3,4- oxadiazole derivatives incorporating substituted dihydropyrimidinone and chloroquinoline moieties 4(a-j) has been reported. All the synthesized compounds were characterized by FTIR, 1H NMR and Mass spectroscopy. The compounds were screened for their in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitr...

Ambareen Shaikh* and Jyotsna Meshram

Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4607-14

4607-4614

1692

651

20.

ANTI-ULCER ACTIVITY OF PHYSALIS MINIMA PLANT EXTRACT IN ALBINO RATS

Peptic ulcer is the most common gastrointestinal disorder in clinical practice. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but these drugs has shown incidence of relapses, side effects, and drug interactions. Thus the development of new antiulcer drugs and the search for novel molecules has been extended to herbal...

T. Joshi Anand*, R. Ratna Manjula, SK. Liakhat Ali, M. Hindu Sai and V. Padmaja

Department of Pharmacognosy, Nirmala College of Pharmacy, Atmakur, Mangalagiri, Guntur (dt), 522503, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4615-18

4615-4618

3131

978

21.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TENOFOVIR DISOPROXIL FUMERATE AND EFAVIRENZ IN BULK AND FORMULATION

The objective of the present work was to develop a simple, rapid, accurate RP-HPLC method for the simultaneous estimation of Tenofovir disoproxil fumerate (TDF), Efavirenz in bulk and formulation. The chromatographic separation was achieved by isocratic mode of elution by using Agilent Zorbax Eclipse XDB C18 (150 x 4.6mm, particle size 5µm) analytical column. The mobile phase consisting of Aceton...

D. Sri Vidya*, Y.A. Chowdary and T.E.G.K. Murthy

Department of Pharmaceutical Analysis & Quality Assurance, Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4619-24

4619-4624

2221

652

22.

COMPARATIVE STUDY OF ANTIULCER ACTIVITY OF METHANOLIC EXTRACTS OF WATTAKAKA VOLUBILIS (LINN.F.) STAF AND TABEBUIA ROSEA (BERTOL.) DC IN RATS

The aim of this study was to compare the antiulcer activity of methanolic extracts of Wattakaka volubilis (Linn.f.) Staf and Tabebuia rosea (Bertol.) DC in rats. The anti-ulcer effect was evaluated using Anti secretary model (chemical induced pylorus ligation). Ranitidine were used as standard drugs for ulcer studies. The extracts were administered orally at 500 mg/kg. The result of the present st...

A. Suvarchala Kiranmai*, K. Hemamalini and Uma Vasireddy

TRR College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4625-31

4625-4631

1692

614

23.

CRYSTAL MODIFICATION OF ATOVAQUONE IN PRESENCE OF POLYETHYLENE GLYCOL (PEG) 4000

Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. Its inhibitory effect being comparable to ubiquinone, in sensitive parasites atovaquone can act by selectively affecting mitochondrial electron transport and parallel processes such as ATP and pyrimidine biosynthesis. It exhibits low bioavailability related to its poor water solubilit...

P.A. Pangarkar*, R.S. Wanare and A.M. Tayde

S. N. Institute of Pharmacy, Pusad- 445 204, Dist. Yavatmal, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4632-41

4632-4641

2389

827

24.

NEW POTENTIAL ALLELOCHEMICALS FROM AERIAL PARTS OF INDIGOFERA TRIFOLIATA LINN.

Two new potential allelochemicals were isolated from ethanolic extract of the aerial parts of Indigofera trifoliata Linn. Along with three known compounds Tricin (3), Taraxerol (4) and 5-hydroxy-3, 4′, 7-trimethoxyflavone (5). The structures of  new allelochemicals were characterized as 6, 3′, 4′-trihydroxy-5, 7, 8-trimethoxyflavanone-4′-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-xylopyranosyl...

R.N. Yadava* and U.K. Vishwakarma

Natural Products Laboratory, Department of Chemistry, Dr. H.S. Gour University, Sagar- 470003, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4642-49

4642-4649

1538

656

25.

SEDATIVE AND HYPNOTIC ACTIVITY OF BULBS OF ALLIUM CEPA LINN.

The onion (Allium cepa L), also known as the bulb onion or common onion, is used as a vegetable and is the most widely cultivated species of the genus Allium. Allium cepa L belongs to the family Lilliaceae. The onion has a wide range of beneficial actions on the body and when eaten (especially raw) on a regular basis will promote the general health of the body. The parameters selected were prelimi...

S.V. Mahalakshmi Rampalli*, Rajyalaxmi Gudepu, Md. M. Rabbani and Yasodha Krishna Janapathi

Department of Pharmacology, Sri Sarada College of Pharmacy, Bhongir, Nalgonda-508116, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4650-55

4650-4655

5695

776

26.

FORMULATION AND EVALUATION OF ENGINEERED PHARMACEUTICAL FINE PARTICLES OF BUDESONIDE FOR DRY POWDER INHALATION (DPI) PRODUCED BY AMPHIPHILIC CRYSTALLIZATION TECHNIQUE: OPTIMIZATION OF PROCESS PARAMETERS

The purpose of this study was to produce of microparticles for Dry Powder Inhalation, produced by environmentally driven Amphiphilic crystallization technique process by using different nonionic surfactants at different concentration and at different processing parameters, for inhalation therapy. Budesonide, as one of the inhaled glucocorticosteroids, is widely used in the treatment of asthma by p...

P.S. Uttekar* and P.D. Chaudhari

Institute of Pharmacy, National Institute of Medical Sciences (NIMS) University, Shobhanagar, Jaipur, Rajasthan India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4656-70

4656-4670

2034

719

27.

DESIGN, SYNTHESIS AND EVALUATION OF SOME NEW ISOXAZOLES, CYANO-PYRIDINES AND 1, 5 BENZOTHIAZEPINES AS ANTIMICROBIAL AGENTS

The title compounds (7a-f), (8a-f) and (9a-f) have been prepared from chalcones (6a-f) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium acetate give isoxazoles (7a-f) and cyanopyridines (8a-f) respectively. Chalcones (6a-f) on condensation with 2-amino thiophenol in the presence of gl...

A. Solankee* and R. Patel

Department of Chemistry, B. K. M. Science College, Valsad-396001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4671-75

4671-4675

1507

554

28.

SPECTROPHOTOMETRIC DETERMINATION OF DILTIAZEM IN PHARMACEUTICAL AND IN-VIVO SAMPLES WITH Pd(II)

An analytical method has been developed for quantitative determination of diltiazem, chemically (+)-cis-1,5-benzothiazepin-4-(5H)one, 3-(acetyloxy)-5-[2-(dimethyl amino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-monohydro chloride, by complexation with Pd(II) spectrophotometrically. Diltiazem is a calcium channel blocker type antihypertensive drug.  Diltiazem forms an stable orange colored 1:2 comple...

Rupali Shrivastava

Department of Chemistry, Rajdhani Engineering College, Rohini Nagar, PHASE-I, Sanaganer- Renwal Road, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4676-81

4676-4681

1952

615

29.

IN-VITRO EVALUATION OF ANTIOXIDANTS ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF CELASTRUS PANICULATUS

Celastrus paniculatus is an important medicinal plant used in India. Traditionally seed oil of this herb is used widely in several medicinal preparations and its bark is used in malaria in folk medicines. It is endangered and vulnerable plant. The investigation used Reducing power assay and Total phenolic content to determine antioxidant potential in the ethanolic extract of the drug. The result s...

Priyanka Sharma* and N.M. Shrivastava

Department Of Pharmacy, Barkatullah University Bhopal, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4682-84

4682-4684

1785

714

30.

IDENTIFICATION OF SMALL MOLECULE INHIBITORS AGAINST AMYLOID β (Aβ) OLIGOMERIZATION AND TOXICITY FROM NOOTROPIC AYURVEDIC HERBAL EXTRACTS

Central pathogenic mechanism of Alzheimer’s disease (AD) involves aggregation of amyloid β (Aβ) protein to form toxic oligomers. Identifying novel small molecules that inhibit the aggregation of monomeric Aβ to toxic oligomeric species can be an effective disease modifying strategy for AD. In the present study, plants being used in Ayurveda for treating dementia as well as to improve memory a...

Maya Mathew, B.K. Chandrasekhar Sagar and Sarada Subramanian*

Additional Professor, Department of Neurochemistry, National Institute of Mental Health & Neurosciences, Bangalore – 560 029, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4685-91

4685-4691

3264

792

31.

EVALUATION OF ANTIDEPRESANT ACTIVITY OF SPINACIA OLERACEAE BY USING ALBINO RATS

Herbal and natural products of folk medicine have been used for centuries in every culture throughout the world. Scientists and medical professionals have shown increased interest in this field as they recognize the true health benefits of these remedies. Spinach is a leafy green vegetable that came originally from south-western Asia and is now grown in most parts of the world. Scientifically it i...

Rajya Laxmi Gudepu*, S.V. Mahalakshmi Rampalli and J. Yasodha Krishna

Department of Pharmacology, Sri Sarada College of Pharmacy, Bhongir, Nalgonda- 508116, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4692-96

4692-4696

1761

643

32.

EFFECTS OF PREMNA INTEGRIFOLIA LINN. ROOTS EXTRACTS IN CCL4 INDUCED TOXICITY IN RATS

Premna integrifolia Linn. roots are used in the Indian system of medicine for the treatment of diabetes, inflammation, liver disorders etc. The present study was aimed to investigate the antioxidant activity of Premna integrifolia L. (Family: Verbenaceae) in CCl4 (carbon tetrachloride) induced oxidative stress in Sprague- Dawley rats. CCl4 injection induced oxidative stress by a significant rise i...

Sanjay Jain*, Mamta Singh, Rakesh Barik and Neelesh Malviya

Department of Pharmacognosy, Smriti College of Pharmaceutical Education, 4/1, Pipliya Kumar Kakkad, Mayakhedi Road, Nipania, Indore 452010, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4697-03

4697-4703

1952

590

33.

CLASSIFICATION OF EMPLOYEE TURNOVER INTENTION USING HIERARCHICAL CLUSTER ANALYSIS: A CASE STUDY FROM INDIAN PHARMACEUTICAL COMPANIES

The aim of this paper is to study the employee turnover ratio in an Indian pharmaceutical company in India. Primary data were collected from 50 employees of two pharmaceutical companies using questionnaire methods. The questionnaire data was grouped to produce a concise representation of the human resource turnover retention using hierarchical clustering (HC) technique. The results of HC have grou...

R. Lakshmi Devi*, R. Amalraj and S. Prasanna Devi

Mother Theresa Women University, Kodaikanal, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4704-07

4704-4707

3681

906

34.

FORMULATION & EVALUATION OF BUFFERED PANTOPRAZOLE SODIUM TABLET

The aim of this study was to prepare buffered tablets of acid labile drug, Pantoprazole sodium for oral administration using buffering agents to protect a drug from gastric fluid. Its mechanism of action was inhibition of H+/K+-adenosine triphosphate, an enzyme present in the gastric parietal cells. The tablets were prepared by wet granulation method. The formulations contain sodium carbonate, sod...

Mukesh P. Ratnaparkhi*, Pravin S. Pongale and Shilpa P. Chaudhari

Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon (Kalewadi), Pune- 411 033, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4708-14

4708-4714

5171

914

35.

DESIGN AND FABRICATION OF GASTRORETENTIVE BILAYER FLOATING TABLET OF PROPRONOLOL HCl USING NATURAL POLYMER

The purpose of this study is to prepare a bilayer gastro retentive tablet of Propranolol HCl using direct compression technology and optimize the type and concentration of polymer to give maximum retentive effect with good drug release profile. Propranolol hydrochloride, a nonselective β-adrenergic blocker having short half-life (3-4 hr)and first pass metabolism favors for sustained release dosag...

P.H. Wakde*, R.H. Kasliwal and S.B. Mane

J.L. Chaturvedi College of Pharmacy, Electronic Zone Building, MIDC, Hingna Road, Nagpur- 440 016, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4715-28

4715-4728

2327

630

36.

DYNAPAR AQ IV BOLUS INJECTION FOR POSTOPERATIVE PAIN

Aim: To evaluate safety and efficacy of diclofenac 75 mg/1ml (Dynapar AQ) administered as IV bolus versus diclofenac 75mg/3ml administered as IV infusion in patients with postoperative pain. Methods: 350 postoperative adult patientswere randomized to receive either treatment. Primary efficacy endpoints were time to onset of analgesia and postoperative pain intensity while secondary efficacy end...

S. K. H. Maroo*, P.N. Kakar , A. K. Varshney , B. M. Subnis , J. A. Bogra , S. N. Mohite , P. N. Shah , TVSP. Murthy , D. H. Ruparel , K. R. Patel and R. U. Ojha

Medical Services Department, Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat , India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4729-35

4729-4735

43065

2916

37.

A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METRONIDAZOLE AND CIPROFLOXACIN HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

A reversed-phase-liquid chromatographic (RP-HPLC) method was developed for the determination of Metronidazole (MTZ) and Ciprofloxacin HCl (CPX) in their bulk drug and marketed formulations. The separation was carried out using a mobile phase of 25mM Potassium dihydrgen phosphate buffer of pH 3.0 consisting of 0.15%v/v Triethylamine, 0.1% Phosphoric acid  and Methanol in the ratio of( 60:40v/v). T...

S.S. Khadabadi * and Meenakshi G. Devkar

Department of Pharmaceutical Chemistry, Government college of Pharmacy, Osmanpura, Aurangabad-431005, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4736-40

4736-4740

3499

1047

38.

ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF METHANOLIC EXTRACT OF FILICIUM DECIPIENS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

This study evaluated methanolic extract of Filicium decipiens (MFD) on reducing hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats. MFD was orally administered once a day after 3 days of streptozotocin -induction at 100,200 and 400 mg/kg for 45 day and the results showed that serum fasting blood glucose, Glucose – 6 – phosphotase , Fructose 1, 6 –phosphotase in hepatic ...

C. Sasikala* and Yajaman Sudhakar

Shri Vishnu College of Pharmacy, Bhimavaram- 534 202, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4741-44

4741-4744

1896

796

39.

EVALUATION OF ANTIBACTERIAL ACTIVITY OF SYZYGIUM AROMATICUM, LAURUS NOBILIS AND CUMINUM CYMINUM EXTRACTS AND THEIR COMBINATION

Antibacterial agents are essential drugs for human health and welfare. Many pharmaceutical industries have produced a number of antibiotics and resistance to these drugs by microorganisms increased. This development of resistance has necessitated the search for new anti-bacterial agents. Medicinal plants like spices are considered as a good source of natural products for maintaining human health s...

Chaitanya Sravanthi Kota* and Spoorthy Paladi

Vignan Institute of Pharmaceutical Sciences, Deshmukhi Village, Nalgonda-508824, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4745-48

4745-4748

2119

815

40.

ROLE OF SPERM NUCLEAR DNA INTEGRITY STATUS AND THE SEMEN QUALITY OF FERTILE AND INFERTILE MEN

The aim of the study is to evaluate the diagnostic DNA profiles of the assessment of semen analysis data with respect to male fertility potential. Seman analysis taken form 50 patients of known fertility and 50 suspended infertility were studied by conventional semen analysis by suitable methods. The acridine orange test was used to assess the integrity of sperm DNA. The data throw doubt upon the ...

K. Sudhagar*, R. Balajee and M.S. Dhana Rajan

Nandita’s fertility & Research Centre , 212, McNichols Road, Chetpet, Chennai – 600031, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4749-53

4749-4753

1480

503

41.

PROTECTIVE ACTIVITY OF SHOREA ROBUSTA LEAF AGAINST OXIDATIVE STRESS IN RATS

Currently there has been an increased interest globally to identify the plant origin with free radical scavenging properties and have great importance as therapeutic agents in several diseases due to oxidative stress. Lipid peroxidation of cellular membranes has also been implicated in various disease processes, including cardiac ischemia-reperfusion injury. In recent years, the use of natural ant...

C. Karthika, M. Chitra and K. Radhika*

Department of Biochemistry, S.T.E.T Women’s College, Mannargudi, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4754-57

4754-4757

2248

591

42.

IN SILICO VACCINE DESIGN AGAINST THE TARGET L1 BINDING PROTEIN OF HUMAN PAPILLOMAVIRUS, AN ETIOLOGICAL AGENT OF CERVICAL CANCER, USING BIOINFORMATICS TOOLS

Human Papilloma Virus (HPV) is the smallest virus in the world. HPV is a non-enveloped double-stranded circular DNA virus, which can widely infect human skin and reproductive tract and respiratory epithelium. HPV also has a close relationship with benign and malignant tumors. There is no universal HPV treatment. Although there is a vaccine called Gardasil that can prevent some diseases caused by H...

Shuchi Kaushik , Vivek Kumar Shrivastav , Archana Shrivastav and Asha Mukul Jana*

Department of Biotechnology 1, College of Life Sciences, Cancer Hospital & Research Institute Campus, Gwalior- 474 009, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4758-62

4758-4762

2302

715

43.

IMMUNOSUPPRESSIVE EFFECT OF SWERTIA CHIRATA BUCH HAM. ON SWISS ALBINO MICE

Swertia chirata Buch Ham (Gentianaceae) commonly known as chiratais a perennial herb. The present study was undertaken to evaluate the immunomodulatory effect of methanolic extract of S. chirata aerial part on Swiss albino mice. Haemagglutination Test (Humoral antibody response) and Delayed-type hypersensitivity (DTH) response test and were done to investigate the effect of methanolic extract of S...

Laxmi Ahirwal*, Siddhartha Singh, Vandana Bharti and Archana Mehta

Laboratory of Plant Pathology and Biotechnology, Department of Botany, School of Biological and Chemical Sciences, Dr. H.S. Gour Central University, Sagar- 470003, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4763-68

4763-4768

1822

663

44.

PHYTOCHEMICAL SCREENING STUDY AND CONSTIPATION ACTIVITY OF SPERMACOCE HISPIDA L. (RUBIACEAE) BY USING ALBINO RATS

The whole plant of Spermacoce hispida L is reported to have great medicinal value.It is found effective systemically in treating, headache, constipation, anti-hypertensive, anti-fertility, Appetite, Scabies, Irritant bowel syndrome and skin disease etc. Intake of 2 to 4 g of the seeds along with a mixture of dry ginger, coriander seed andfinger millet reduces the unwanted cholesterol namely LDL an...

G. Muthuboopathi*, K. Padmalatha , S. Sundar , K. Poojitha and V. Hindu Addala

Vijaya Institute of Pharmaceutical Sciences, Enikepadu, Vijayawada, Krishna District, Andhra Pradesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4669-74

4669-4774

1876

669

45.

FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICRO-SPHERES OF SALBUTAMOL SULPHATE BY USING A NATURAL POLYMER

Salbutamol  sulphate (SS)  loaded  microspheres  were  prepared   by  solvent  evaporation  method  with  combination   of  Sterculia  foetida  gum  in  various  proportions.  A total  of  eighteen  formulations  were  prepared  in  different  oil  phases  i.e.,  liquid  paraffin  and  sunflower  oil. Those  prepared  from  liquid  paraffin L1-L9 and  those...

Kavita N. Patil* and Kanchan P. Upadhye

J.L. Chaturvedi College of Pharmacy, Electronic Building, Hingna Road, Nagpur- 440 016, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4775-86

4775-4786

1627

598

46.

EFFECT OF HOMOEOPATHIC MEDICATION ON DEPRESSION

Depression is a well-defined mood disorder which is characterized by state of disposition of mind and dislike or antipathy to activity that can affect an individual’s thoughts, demeanor, sense of emotional touch and physical well- being. Depressed people may feel mournful, troubled, uneasy in mind, meaningless, helpless and unworthy, experiencing as if having committed an offence. They are easil...

Girija Shankar Shukla

Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences- Deemed University, Allahabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4787-97

4787-4797

2895

649

47.

ETHNO-MEDICINAL STUDY OF HERBS USED BY RURAL AND TRIBAL COMMUNITY IN BETUL DISTRICT OF MADHYA PRADESH, INDIA

The investigation on the local knowledge about traditional herbal medicine is becoming increasingly important in defining strategies and actions for conservation of medicinal plants. This study therefore considered worthwhile to collect information from local rural and tribal population living in Betul district of Madhya Pradesh (India) concerning the use of medicinal plants; identify the most imp...

U.K. Patil

Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, 470003, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12). 4798-4816

4798-4816

1427

403

48.

A PRELIMINARY INVESTIGATION OF TUMOR TAKE INHIBITORY ACTIVITY OF ETHANOLIC LEAF EXTRACT OF MURRAYA KOENIGII LINN. IN MICE

The present study was undertaken to explore the tumor take inhibitory effects of ethanolic extract of Murraya koenigii in rodents. Tumor take inhibitory activity was investigated in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth o...

D. Iyer and U. K. Patil*

Division of Pharmacognosy and Natural Product Research, Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar, Madhya Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4817-20

4817-4820

820

264