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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 7 (2016) - Issue 1, January

Review Articles

 
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1.

QUINOLINE: A DIVERSE THERAPEUTIC AGENT

Quinoline and its derivatives are diverse pharmacological agents. They play a vital role in the development of new therapeutic agents. Many new therapeutic agents have been developed by using quinoline nucleus. Hence quinoline and its derivatives constitute an important class of heterocyclic compounds for the new drug development. Quinoline is also known as 1-azanapthalene and many researchers hav...

Anjali *, Dharampal Pathak and Divya Singh

Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Sciences and Research University, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.7(1).1-13

1-13

5097

2239

2.

PHYTOCHEMICALS AND COMPLICATIONS IN TYPE 2 DIABETES-AN UPDATE

Type 2 diabetes is a serious health problem globally. In type 2 diabetes insulin resistance in various tissues such as liver, muscle and β-cell is the major pathophysiological defects. People with long term uncontrolled hyperglycemia are at risk of developing a number of serious and life-threatening complications which mainly affect the heart and blood vessels, eyes, kidneys, and nerves. Current ...

Manisha J Oza and Yogesh A. Kulkarni*

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle (W), Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(1).14-24

14-24

3959

1588

3.

NOVEL APPROACHES OF NANOPARTICLE TOWARDS DRUG DELIVERY SYSTEM

Over the past few decades, the pursuit and exploration of nanotechnology is likely to have a significant impact on the drug-delivery system. This technology can be envisioned as playing a major role in revolutionizing the future of novel drug delivery system. Nanoparticles (NPs) are one of them which have many potential applications in clinical medicine and research. The encapsulation of therapeut...

Deepika Singh *, Amita Verma and Shashi Alok

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Deemed to be University, Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(1).25-30

25-30

3299

1523

4.

A REVIEW ON UNANI TRADITIONAL USES OF SAMBHALU IN FEMALES AS WELL AS PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES

Herbal medicine, rather than merely curing a particular disease, aims at returning the body back to its natural state of health. Vitex negundo Linn. known as Sambhalu in Unani medicine belongs to family Verbenaceae. It is a large aromatic shrub distributed throughout India. It has been used since ancient times as a female remedy in Unani medicine. It is a well known plant because of its two main p...

M. Roqaiya *, W. Begum and S. F. Majeedi

Department of pharmacy, S.M.B.T. Institute of Diploma of Pharmacy Dhamangaon, Nashik, MS, India

DOI: 10.13040/IJPSR.0975-8232.7(1).31-41

31-41

4520

2283

5.

A REVIEW ON THERAPEUTIC POTENTIAL OF NELUMBO NUCIFERA (GAERTN): THE SACRED LOTUS

objectives: Nelumbo nucifera Gaertn (Nelumbonaceae) known by numerous common names including Indian lotus, sacred lotus, bean of India, or simply lotus is one of the most important medicinal plants. In this review there is discussion about therapeutic potential of the different parts of the plant (leaves, seeds, flower, and rhizome) which can be used in traditional system of medicine. This review ...

Alok Bhardwaj * and K. P. Modi

School of Pharmacy, R. K. University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).42-54

42-54

6107

2221

6.

ANTIMICROBIAL ACTIVITY OF UPAVISHA AND ITS CLINICAL CORRELATION WITH CONTEMPORARY SCIENCE: A REVIEW

In Ayurveda, there are less toxic herbal drugs known as upavisha. Upavisha are mostly use in various diseases with many therapeutically preparations. As per Ayurveda, Upavisha is group of less toxic drug. These drugs are either not having all ten gunas or they have less potent gunas. The properties of these drugs are to cure acute and chronic disease. These groups also have antimicrobial/ anti- in...

Rohit Kumar Khatik, Anita Sharma and Aarti Kondel

Department of Agad Tantra & Vyavhara Ayurved National Institute of Ayurved, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(1).55-61

55-61

4308

1567

Research Articles

 
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7.

A NOVEL TANNIC ACID FROM GANODERMA LUCIDUM FRUITING BODIES EXTRACT AMELIORATES EARLY DIABETIC NEPHROPATHY IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Aim: The present study evaluated the anti-diabetic, anti-hyperlipidimeic, antioxidant activities and renal protective effect of aqueous extract from Ganoderma. lucidum fruiting bodies in streptozotocin induced diabetic rats. Material and Results: Qualitative and quantitative phytochemical analysis for G. Lucidum aqueous extract showed the Presence of high concentration of tannins content. Thin lay...

E. M. Elhussainy, N. A. Elzawawy * and S. H. Shorbagy

Microbiology Department, Faculty of Science, Tanta University, Tanta, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(1).62-75

62-75

2825

1252

8.

ANTIOXIDANT AND ANTIBACTERIAL OF AERIAL PART ESSENTIAL OIL AND SOME ORGANIC EXTRACTS FROM THE ALGERIAN MEDICINAL PLANT PULICARIA MAURITANICA COSS

Pulicaria mauritanica Coss is one of the endemic medicinal plants from Algerian Sahara. It’s used for many traditional therapies for various diseases. The aims of this study were to analyse the chemical composition of aerial part essential oil of P.mauritanica coss and antibacterial properties. We investigate the content of different organic extracts on phenolics and flavonoids, and also their a...

Mohammed Gherib *, Bekhechi Chahrazed, El HACI Imad Abdelhamid, Tarik Mohammed Chaouche and Fawzia Atik- Bekkara

Laboratory of Natural Products, Department of Biology, Faculty of Sciences, Abou Bekr Belkaïd University, Algeria

DOI: 10.13040/IJPSR.0975-8232.7(1).76-84

76-84

3141

1520

9.

PHARMACOLOGICAL OVERVIEW OF PROANTHOCYANIDINS FROM THE BARK OF THESPESIA POPULNEA (L.) AS AN ANTIOXIDANT AND CYTOTOXIC AGENT

The preliminary phytochemical analysis of the aqueous ethanolic extract of the bark of Thespesia populnea (L.) revealed the presence of alkaloids, unsaturated sterols, triterpenes, flavonoids and the absence of anthraquinones. The froth test indicated the presence of saponins. Most importantly this study revealed the presence of proanthocyanidins which has not been reported before. In the present ...

C. Padumadasa *, A. M. Abeysekara, I. Thabrew and A.P.G.R. Ediriweera

Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka

DOI: 10.13040/IJPSR.0975-8232.7(1).85-92

85-92

2700

1305

10.

PREPARATION AND IN VITRO EVALUATION OF IN SITU GELLING GASTRORETENTIVE SALBUTAMOL SULFATE LIQUID FORMULATIONS

Salbutamol is a selective β2-adreno-receptor stimulant and is given four times daily in a dose of 2.4 mg orally to maintain therapeutic blood level. It is known to be absorbed in proximal parts of the small intestine. Prolonging gastric residence time is, therefore, beneficial to improve its bioavailability. Hence, seven in situ gelling liquid formulations were prepared using sodium alginate (SA)...

Abrham Temesgen, Anteneh Belete, Tsige Gebre-Mariam*

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, Addis Ababa University, PO Box 1176, Ethiopia

DOI: 10.13040/IJPSR.0975-8232.7(1).93-01

93-01

3184

1365

11.

SYNTHESIS OF HETEROCYCLIC NITROGEN COMPOUNDS BY CLOSURE REACTIONS USING TETRAACETYLETHANE WITH VARIOUS PRIMARY AMINES

This work includes synthesis of new five, six, and seven-heterocyclic nitrogen compounds by closure reactions of tetraacetylethane (3) with primary amines in refluxing ethanol and acetonitrile as solvents and without using any catalysts. The tetraacetylethane melting point 184-189 ºC was prepared by condensation of two anhydrous molecules of sodium salt of acetylacetone and in the presence of dry...

Abdulmajeed S. H. Alsamarrai* and Hamid J. Mohammad

Chemistry Department, College of Applied Science, University of Samarra, Salahaldin, Iraq.

DOI: 10.13040/IJPSR.0975-8232.7(1).101-07

101-07

3088

1180

12.

PRELIMINARY STUDY ON THE ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF IPOMOEA MURICATA (LINNAEUS) JACQUIN

Acetylcholinesterase (AChE), a member of α/ß hydrolase protein super family, is the key enzyme in the breakdown of acetylcholine (ACh) - an important neurotransmitter. Inhibition of this enzyme has been considered an auspicious strategy for the treatment of various neurological disorders such as Alzheimer’s disease (AD). In this study, crude methanolic Ipomoea muricata seed extract was subject...

L. A. Santiago*, P. J. O. Pineda and M. L. G. Gerona

Research Center for the Natural and Applied Sciences, Department of Biochemistry, Faculty of Pharmacy, The Graduate School, University of Santo Tomas, España Blvd. Manila, Philippines.

DOI: 10.13040/IJPSR.0975-8232.7(1).108-14

108-14

2628

1283

13.

FORMULATION AND EVALUATION OF AQUEOUS EXTRACT OF GARLIC (ALLIUM SATIVUM) AS A PESSARY

A pessary is a type of suppository that is meant to be inserted into the vagina for treatment of local or systemic diseases, in folk medicine garlic bulb is inserted into vagina for treatment of candidiasis. The aim of this work is to formulate and evaluate aqueous extract of garlic as a pessary. Aqueous garlic (Allium sativum) extract was obtained from the garlic bulbs. The pessary was formulated...

J. Muazu * and H. Amos

Department of Pharmaceutics and Pharmaceutical Microbiology, University of Maiduguri, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.7(1).115-20

115-20

2428

1500

14.

IN-VITRO ANTIOXIDANT EFFECTS OF TANNIN EXTRACTS OF PISTACIA ATLANTICA

Seven parts of Pistacia atlantica were collected from Tlemcen in Algeria (fruits, leaves, buds, stems, roots internal and external trunk barks). Tannin content was determined and antioxidant activity of tannic extracts were measured using different assays: Total antioxidant capacity, 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power (FRAP) and β-carotene bleaching assay The results showed that...

Fethi Toul*, Nabila Belyagoubi-Benhammou, Amel Zitouni, Nacéra Ghembaza and Fawzia Atik-Bekkara

Département de Biologie, Faculté des Science de la Nature et de la Vie, des Sciences de la Terre et de l’Univers, Université Abou BakrBelkaid, BP 119, Imama, Tlemcen, Algérie.

DOI: 10.13040/IJPSR.0975-8232.7(1).121-26

121-26

2213

826

15.

ANTI-NOCICEPTIVE ACTIVITY AND POSSIBLE MECHANISMS OF ACTION OF AQUEOUS ROOT EXTRACT OF STROPHANTHUS HISPIDUS DC (APOCYNACEAE)

Background: Decoction of the root of Strophanthus hispidus is highly valued in Africa herbal medicine for the treatment of skin diseases, leprosy, ulcers, malaria, dysentery, gonorrhea and in the management of inflammation. Objective: The present study aimed to evaluate the anti-nociceptive effect of the aqueous root extract of Strophanthus hispidus focusing on central involvement as well as explo...

Samuel Muyiwa Fageyinbo, Oluwatoyin Esther Agbaje, Kunle Rotimi, Victor Ikumawoyi, Adeyemi and Yinka Fashina

Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba-Lagos Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(1).127-35

127-35

2317

992

16.

ANALGESIC, CNS DEPRESSANT AND CYTOTOXIC ACTIVITIES OF LEAVES EXTRACT OF DILLENIA INDICA LINN.

The aim of present study was to examine the analgesic, neuropharmacological and cytotoxic effects of the methanolic extract of the barks of Dillenia indica Linn. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail-flick method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 100, 200 and 400 mg/kg body weight...

Fatema Mahnur Mohona , Md. Mofazzal Hossain, Md. Mehedi Hasan and Satyajit Roy Rony *

Pharmaceutical Sciences Research Division, Bcsir Laboratories, Dhaka, Bcsir, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(1).136-43

136-43

2374

1074

17.

EFFECT OF MEDICATIONS-RELATED BELIEFS ON ADHERENCE TO TREATMENT OF TYPE II DIABETES MELLITUS IN A PRIMARY HEALTHCARE SETTING, ADDIS ABABA, ETHIOPIA

Studies reported from Ethiopia depict poor health outcomes and management of diabetes cases and low patients’ adherence to recommended regimens including medications. Among factors determining adherence to medications that are amenable to interventions are patient perceptions to their recommended medications. This study thus aimed to assess adherence to anti-diabetic medications and determinant ...

Girma Bizu and Bruck Messele Habte*

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Ethiopia.

DOI: 10.13040/IJPSR.0975-8232.7(1).144-52

144-152

2638

1049

18.

A NEW HYDRAZONE DERIVATIVE AS A SENSITIVE ANALYTICAL REAGENT FOR THE DETERMINATION OF Co(II) IN FOOD, WATER AND SYNTHETIC SAMPLES

A novel (N', N''E, N', N''E)- N', N'' - (2, 2' - (propane-1,3-diylbis(sulfanediyl))bis(1-(4-chlorophenyl) ethan – 2 – yl – 1 -ylidene))bis(2-hydroxybenzohydrazide)(CAPSH) is identified as a sensitive and selective analytical reagent for the determination of trace levels of Co(II) in environmental samples like in food, water, synthetic samples and medicinal plants by spectrophotometry. CAPSH ...

P. N. Kumar Reddy, G.T. Reddy, S. D. Kumar, A. V. R. Reddy, S. N. Parveen, and N. C. Gangi Reddy *

Analytical Chemistry Division, Bhabha Atomic Research Centre (BARC) Trombay, Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(1).153-62

153-162

2280

991

19.

PHARMACOGNOSTIC STUDIES ON LEAF OF JATROPHA GOSSYPIFOLIA L.

Since, the free radicals induced oxidative stress is posing threat present researchers are focusing on natural sources that could serve as antioxidants to combat the oxidative damage mediated diseases such as diabetes, atherosclerosis and cancer. In this context, present study was carried out to investigate the botanical characters, chemical composition and in vitro antioxidant potential of Jatrop...

R. Saishri, N. Ravichandran, V. Vadivel * and P. Brindha

Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).163-73

163-173

4579

1510

20.

OXIDATIVE SPECTROPHOTOMETRIC ESTIMATION OF DRUGS USING KMnO4 AND METHYL ORANGE AS DYE

Simple, sensitive and selective methods are developed for the spectrophotometric determination of drugs, viz., Esmolol hydrochloride (ESM), Ramipril (RAM), Gemifloxacin (GEM), Terazosin (TRZ) and Moxifloxacin (MOX), based on their reactivity towards KMnO4.  Beer’s law is obeyed in the concentration of 4-28, 4-28, 2.6-18.2, 1.5-10.5 and 1-7 μg ml-1 for Esmolol hydrochloride, Ramipril, Gemifloxa...

Tirupathi Baddenapalli and Venkateshwarlu Gandu*

Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).174-80

174-180

2611

824

21.

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL α-AMINOPHOSPHONATES BEARING A QUINOLINE MOIETY

A novel aminophenylaminoquinoline analogues have been synthesized starting from 4,7 dichloroquinloine and (p-phenylenediamine 2a, o-phenylenediamine 2b or m-phenylenediamine 2c). The one pot reaction with aldehydes and triphenylphosphite in presence of LiClO4 as a Lewis acid catalyst led to the formation of novel α-aminophosphonate derivatives bearing quinoline moiety in good yields. The synthesi...

Ahmed A. El Gokha, Ibrahim M. S. Ghanim, Ahmed El S. Abdel Megeed, Elkhabiry Shaban and Ibrahim El-Tantawy El Sayed*

Department of Chemistry, Faculty of Science, El Menoufia University, Shebin El Koom, Egyp

DOI: 10.13040/IJPSR.0975-8232.7(1).181-89

181-189

4567

1108

22.

LORNOXICAM AND FRANKINCENSE OIL TRANSDERMAL GEL: A POTENTIAL FORMULATION FOR MANAGEMENT OF INFLAMMATION

Inflammation is usually accompanied by pain. The pathogenesis of pain involves not only nociception i.e. the aspect related to sensation of pain but also the emotional aspect involving the pain related fear and stress. Lornoxicam is a non-steroidal anti-inflammatory drug of oxicam class. Frankincense oil, used commonly in aromatherapy, has been known to have calming and grounding effect on emotion...

Sunita Y. Ranade * and R. S. Gaud

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS. V. L. Mehta Road, Vile Parle (West), Mumbai- 400056, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).190-98

190-198

2400

945

23.

FORMULATION AND EVALUATION OF AMLODIPINE BESYLATE ORAL THIN FILMS

The aim of the present work was to formulate and evaluate oral thin films for sublingual administration of Amlodipine besylate. Amlodipine besylate is a calcium channel blocker used in the treatment of hypertension, angina and other cardiovascular diseases. Films were formulated using HPMC (15cps, 60cps), PVA, and HPC as different film-forming agents (3 and 4% (w/v)). Poly ethylene glycol 400 was ...

P. Ramya Deepthi * and K. Satish Kumar

Department of Pharmaceutics, Lalitha College of Pharmacy, Anurag group of institutions, Hyderabad, Telangana state, India

DOI: 10.13040/IJPSR.0975-8232.7(1).199-05

199-205

3783

2501

24.

PHILADELPHIA CHROMOSOME IN PRETHERAPEUTIC CASES OF CHRONIC MYELOGENOUS LEUKEMIA

Chronic myeloid leukemia (CML) is a clonal myel0 proliferative disorder due to neoplastic transformation of myeloid stem cells. The characteristic Philadelphia Chromosome translocation t(9:22) (q 34: q11) juxta poses the c-abl oncogene from chromosome 9 with break point cluster region (bcr) on chromosome 22 resulting in the generation of aberrant bcr/abl transcripts. The abnormal bcr/abl tyrosine ...

M. K. Naik, D. N. Mishra, S. Rout *, P. Panda, S. K. Panda, S. R. Das, T. Mishra and C. Mohapatra

Department of Microbiology, IMS and SUM Hospital, Siksha ‘O’ Anusandhan University, Kalinga Nagar, Bhubaneswar, India

DOI: 10.13040/IJPSR.0975-8232.7(1).206-20

206-220

2034

718

25.

SCREENING AND ISOLATION OF BACTERIA FROM KANJAMALAI HILL FOR ANTIMICROBIAL ACTIVITY

Many microorganisms thrive on the abundant nutrients in the rhizosphere and they produce antagonistic metabolites. The present study is an attempt to investigate the potent bacteria producing antibiotics against pathogenic microorganisms from the rhizosphere soil samples of Kanjamalai hills, Salem district, Tamilnadu, India. A total of 6 isolates of bacteria was obtained and screened for inhibitor...

C. Nirmala *, M. Sridevi and Atul Kumar Kushwah

Department of Biotechnology, VMKV Engineering College, Vinayaka Missions University, Salem, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(1).221-27

221-227

2655

1126

26.

STRUCTURE BASED MOLECULAR DOCKING STUDIES ON SOME 1,3-DISUBSTITUTED UREA DERIVATIVES AS ANTI-TUBERCULAR AGENTS

Docking is a method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex and is frequently used to predict the binding orientation of small molecule drug candidates to their protein targets and plays an important role in the rational design of drugs. The present study has been focused on the Docking studies of 1,3-disubstituted urea...

Shivangi Agarwal, Mitali Mishra, Vikash K. Mishra, Varsha Kashaw and Sushil K. Kashaw *

Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar-M.P., India

DOI: 10.13040/IJPSR.0975-8232.7(1).228-35

228-235

2171

1007

27.

SYNTHESIS, PHYSICO-CHEMICAL INVESTIGATIONS AND BIOLOGICAL SCREENING OF METAL (II) COMPLEXES WITH HYDRAZONE SCHIFF BASE DERIVED FROM 5-FLUORO-3-HYDRAZONOINDOLIN-2-ONE AND ISOPHTHALALDEHYDE

New tetradentate Schiff base and its Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes formed by the condensation of 5-fluoro-3-hydrazonoindolin-2-one with isophthalaldehyde. The coloured complexes were prepared of [MLX2], Where L = Schiff base hydrazone, M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), X =  Cl-. Physico-chemical characterization has been carried out to determine ...

K. Siddappa* and M. Nabiya Sultana

Department of Studies and Research in Chemistry, Gulbarga University, Gulbarga, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(1).236-43

236-243

1984

886

28.

PHARMACOGNOSTIC EVALUATION OF TRIPHALA HERBS AND ESTABLISHMENT OF CHEMICAL STABILITY OF TRIPHALA CAPLETS

The use of herbal medicines for the betterment of mankind is well practiced from centuries. Triphala is a well known Rasayana drug used in Indian systems of medicine. Due to its wide spread usage in herbal medicine it drives the attention of regulatory bodies for its safety and efficacy and hence quality become major concern. In the present study we have standardized herbs by Pharmacognostical eva...

A. Shivakumar, S. Paramashivaiah, R. S. Anjaneya, J. Hussain and S. Ramachandran *

Research and Development, The Himalaya Drug Company, Makali, Tumkur Road, Bangalore-562162 Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).244-51

244-251

4573

1367

29.

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE PROTEASE INHIBITOR

There are more than 40% of drugs which are poorly soluble and 90% of the drugs from the pipeline are from BCS class II and IV. Application of  techniques like computers, robotics, high-throughput screening, combinatorial chemistry have resulted in database of huge drug-like molecules which are generally derived solely based on the affinity of the molecule with the target physiological bodies viz....

S. Gupta *, S. Sawarkar and P. Ravikumar

Department of Pharmaceutics, S.V.K.M'S, Dr. Bhanuben Nanavati College of Pharmacy, Mithibhai College Campus, V.M. Road. Vile Parle (W), Mumbai. Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(1).252-58

252-258

3282

1552

30.

CORDIA MYXA POLYSACCHARIDE-G-POLY(ACRYLONITRILE) CO-POLYMER BASED MUCOADHESIVE GASTRORETENTIVE DELIVERY OF CAPTOPRIL

The objective of the present study was to prepare gum Cordia myxa-g-polyacrylonitrile using microwave irradiation and to evaluate its mucoadhesive applications. The graft co-polymerization of poly(acrylonitrile) on gum Cordia myxa was carried out employing 3- level 4-factor central composite experimental design. It was observed that the concentrations of ammonium persulphate and concentrations of ...

Sonia Dhiman, Abhay Asthana *, Ashok K. Tiwary, Manish Jindal and Gyati Shilakari

Department of Pharmaceutics , Maharishi Markandeshwar College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(1).259-71

259-271

2164

882

31.

PHYTOCHEMICAL ANALYSIS OF LEAF EXTRACT OF ECLIPTA PROSTRATA (L.) BY GC- MS METHOD

Eclipta prostrata is a perennial herb, distributed in the tropical and sub- tropical regions of the world. The phytochemical investigation was carried out to determine the possible bioactive components from the methanol extract of Eclipta prostrata leaves by Gas Chromatography and Mass Spectroscopy (GC-MS).100 grams of the powdered sample was subjected to the soxhlet extraction followed by rotary ...

John Wyson W. , M. Deventhiran, P. Saravanan, D. Anand * and S. Rajarajan

P.G & Research Dept. of Botany, Ramakrishna Mission Vivekananda College (Autonomous), Mylapore, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(1).272-78

272-278

4113

1466

32.

A STUDY ON SEROPOSITIVITY OF PLASMODIUM FALCIPARUM AND PAN MALARIAL SPEICES AMONG FEBRILE PATIENTS ATTENDING MIMS GENERAL HOSPITAL, NELLIMARLA, VIZIANAGARAM BY USING PARAHIT TOTAL RAPID TEST KIT METHOD.

Malaria, at one time a rural disease, diversified under the pressure of developments into various ecotypes. These ecotypes have been identified as forest malaria, urban malaria, rural malaria, industrial malaria, border malaria and migration malaria; the latter cutting across boundaries of various epidemiological types. In the present study, an attempt has been made to know the seropositivity of P...

R. Sarath Babu *, Supriya Panda and K. Bhaskara Rao

Department of Microbiology, Maharajah’s Institute of Medical Sciences, Nellimarla, Vizianagaram. Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).279-86

279-286

1901

834

33.

HOMOLOGY MODELING OF HUMAN ASPARAGINASE LIKE PROTEIN AND ITS MOLECULAR INTERACTION STUDIES WITH NATURAL FLAVONOIDS

Asparaginase is used to treat acute lymphoblastic leukemia. Acute lymphoblastic leukaemia is seen in both adults and children. It is a most common pediatric cancer, the disease is more common in ages between 2-5 years children. The causative source of acute lymphoblastic leukaemia to be multiple routes, by genetic susceptibility, endogenous exposure or exogenous exposure. L-asparaginase catalyzes ...

S. K. Gunda *, S. Chary Rudroju, S. Bandi and R. Bodhankar

Bioinformatics Division , Osmania University, Hyderabad, Telangana State, India

DOI: 10.13040/IJPSR.0975-8232.7(1).287-91

287-291

2330

921

34.

ANTIDIABETIC EFFECT OF ETHANOLIC SEED EXTRACT OF DECALEPIS HAMILTONII WIGHT AND ARN ON OXIDATIVE STRESS AND ENZYMIC ACTIVITIES IN ALLOXAN INDUCED DIABETIC RATS

Decalepis hamiltonii Wight and Arn. is an indigenous medicinal plant, which has a folk reputation in Western and southern India as hypoglycemic agent. The present investigation was carried out to evaluate the antidiabetic effect of ethanolic seed extract of Decalepis hamiltonii in alloxan induced diabetic Albino rats. Blood glucose levels and body weights of control and diabetic rats were monitore...

A. Rayar * and R. Manivannan

Department of Chemistry, Government Arts College (Autonomous), Kumbakonam, Tamilnadu State, India

DOI: 10.13040/IJPSR.0975-8232.7(1).292-99

292-299

1809

882

35.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF TROXIPIDE

A simple sensitive, accurate, precise and stability indicating high performance thin layer chromatographic method has been developed and validated for the estimation of troxipide in bulk drug and formulation. The method was developed using silica Gel 60 F254TLC plates, with hexane: ethyl acetate: methanol: water: ammonia 1: 5: 5: 1.5:0.2 (v/v) as mobile phase. The densitometric scanning was perfor...

Arti V. Gajbhar and B. S. Kuchekar *

Department of pharmaceutical Chemistry, MAEER’s Maharashtra Institute of Pharmacy, S. No. 124, MIT campus, Ex- Serviceman Colony, Paud Road, Kothrud, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(1).300-06

300-306

2099

875

36.

DEVELOPMENT AND CHARACTERIZATION OF TENOXICAM ENCAPSULATED NIOSOMES FOR ENHANCED TRANSDERMAL DELIVERY

Objective: The aim of this current research is to study a novel carrier, niosome, for its enhanced transdermal delivery of tenoxicam. Methods: Niosomes are self assembled vesicles composed primarily of synthetic surfactants, cholesterol & edge activator (surfactant). Niosomes were prepared by Organic solvent injection technique and characterized by particle size, entrapment efficiency, transmi...

J. Shaji* and A. Shah

Department of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai- 400005, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).307-15

307-315

2629

869

37.

VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL, PAMABROM AND DICYCLOMINE, HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Simple and rapid Reverse Phase High-Performance Liquid Chromatography (RP-HPLC)  and UV-spectrophotometry method was developed for the determination of Paracetamol, Pamabrom and Dicyclomine hydrochloride, detection was carried out using photo diode array detector. Chromatographic separation of the analytes was achieved within 3.12, 4.25, 5.35 min for Paracetamol, Pamabrom and Dicyclomine hydrochl...

Hemraj Sharma *, Kammili Vishakha, Kondreddy Vinod Kumar and Hari Prasad Bhatta

Analytical Research Laboratory, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur (JNTUA), Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(1).316-24

316-324

2144

1400

38.

STUDIES ON PHYTOCHEMICAL, ANTIBACTERIAL AND ANTIOXIDANT POTENTIALS FROM THE ROOTS OF BOERHAVIA ERECTA. L.

Boerhavia erecta is a weedy herb of the family Nyctaginaceae and is commonly available in almost all places. The  present  study is  so designed  for  phytochemical  screening  of  the plant as well as its  antibacterial and antioxidant activities of the root  extract of B. erecta. The whole plant was collected in and around Chennai.  Phytochemical screening of acetone extract of B. ere...

N. Padma Priya and T.V. Poonguzhali

P.G & Research Department of Botany, Queen Mary’s college, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).325-30

325-330

1967

843

39.

STUDIES ON EVALUATION OF IN-VITRO ANTFUNGAL ACTIVITIES OF MELIA AZEDARACH L. BARK

The present investigation was attempted in order to evaluate the antifungal potential of successively extracted n-hexane and methanolic extracts of Melia azedarach L. bark. The fungi-toxic efficacy of the extracts were tested against both yeast like fungi [Candida albicans (MTCC-3017), Candida krusei, Candida tropicalis, Cryptococcus marinus (MTCC-1029)] as well as mycellial like fungi such as Asp...

A. Khatoon , A. Mohapatra and K. B. Satapathy *

P.G. Department of Botany , Utkal University, Vani Vihar, Bhubaneswar, Odisha, India

DOI: 10.13040/IJPSR.0975-8232.7(1).331-35

331-335

2239

972

40.

EFFECT OF NIMESULIDE IN REVERSING RESERPINE INDUCED DEPRESSION IN MICE

Aim: To demonstrate the effect of Nimesulide in reversing Reserpine induced depression in mice. Materials and Methods: This test was done using 20-25gm of healthy albino mice of either sex in the Department of Pharmacology of Gauhati medical college. They were housed in standard laboratory condition at 25ºC and fed on standard diet and water ad libitum. Five groups were selected each containing s...

Atifa Ahmed* and Mangala Lahkar

Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam, India

DOI: 10.13040/IJPSR.0975-8232.7(1).336-39

336-339

2438

985

41.

ANTI-BACTERIAL EFFICACY OF OCTENIDINE AS A MOUTH WASH

To evaluate the antimicrobial activity of Octenidine (OCT) 0.1%, Chlorhexidine (CHX) 0.2% against bacterial strains of Enterococcus faecalis and Staphylococcus aureus. The strains were inoculated in 7ml of brain heart infusion broth and diluted to reach the concentration equivalent (0.5 McFarland standard). 1ml of organism suspension was contacted with 1ml of each mouthwash and was removed at time...

Aayush Malhotra *, Amit Bali and Rajesh Bareja

Department of oral and maxillofacial Surgery, M.M. College of Dental Sciences & Research, M.M. University, Mullana, Ambala, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).340-44

340-344

4718

1223

42.

A COMPARATIVE STUDY ON THE EXTRACTS OF KALANCHOE PINNATA (LINN.) PERS. USING CHROMATOGRAPHIC TECHNIQUES

Kalanchoe genus is known for its therapeutic values. Kalanchoe pinnata (Linn.) Pers. originating from African continent is known to exhibit wound-healing, antioxidant, anticancer and hepatoprotective activities. Traditionally, it is used to treat stones of the gall bladder. Hence, determination of the phytoconstituents of the plant that are responsible for treatment of various ailments became the ...

PB Rajsekhar*, RS Arvind Bharani, Maya Ramachandran, K Jini Angel and R Sharadha Priya Vardhini

M/s., Rajkeerth Aromatics and Biotech Pvt. Ltd., No. 389, I Floor, Arcot Road, Kodambakkam, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(1).345-48

345-348

2576

953

43.

WOUND HEALING ACTIVITY OF MIMUSOPS ELENGI LINN.

The present study of wound healing activity of mimusops elengi linn was aimed to evaluate this activity of extract of leaves of mimusops elengi. On the basis of traditional use and literature reference, this plant was selected for wound healing activity. A meathanolic extract of leaves of mimusops elengi was examined for wound healing activity in the form of ointment in form of ointment in excisio...

Nandlal Singh*, Vihangesh Dixit, R Irchhaiya and Shashi Alok

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi.(U.P.), India

DOI: 10.13040/IJPSR.0975-8232.7(1).349-52

349-352

2146

1021

44.

STUDIES ON ANTIFUNGAL POTENTIAL OF BRYUM CELLULARE (A MOSS) CRUDE EXTRACTS AGAINST SPORE GERMINATION OF FUNGUS CURVULARIA LUNATA

Chemical protection plays a decisive role in the resistance of plants against various pathogens and their spore germination. The so-called secondary metabolites which are a characteristic feature of plants and are important to protect plants against a wide variety of microorganisms including fungi. In order to this, the present study was carried out to evaluate the antifungal potential of Bryum ce...

G. S. Deora * and N. Guhil

Department of Botany, New Campus, Jai Narain Vyas University, Jodhpur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(1).353-57

353-357

1986

910

45.

PHARMACIST INTERVENTION IN MEDICATION ADHERENCE IN PATIENTS WITH TYPE II DIABETES MELLITUS

Type II diabetes mellitus is a serious global health problem and is associated with considerable morbidity and mortality. According to International Diabetic Federation, by 2030 there is 1 adult in 10 will have diabetes. To achieve long term glycemic control, multiple drugs including parenteral therapy with insulin and oral drugs are needed. Hyperglycemia, diabetes associated complications and co ...

C. S. Manju*, Rinisha Razak, R. Chandni and B. Athira

Department of Pharmacy, Govt Medical College, Kozhikode, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(1).358-62

358-362

2685

930

46.

TRANSCORNEAL PERMEATION OF OFLOXACIN BY AMINO ACID TRANSPORTERS

The research was carried out to formulate and evaluate ophthalmic solutions of Ofloxacin with amino acid transporters and compare the transcorneal permeation of Oflaxacin with that of the standard. In the study three different eye drop formulations were prepared by conjugation of the drug with different amino acids such as Alanine, Glycine and Leucine by solvent evaporation technique, the extent o...

R. E. Ugandar. *, Dinesh Kumar Sharma, Deviki Krishnan and Kiran C. Nilugal

Pacific Academy of Higher Education and Research (PAHER), Pacific University, Udaipur, Rajasthan India.

DOI: 10.13040/IJPSR.0975-8232.7(1).363-69

363-369

1956

749

47.

CHEMOPREVENTIVE ACTION OF EMBLICA OFFICINALIS AGAINST RADIATION AND CADMIUM INDUCED HEPATIC LESIONS IN SWISS ALBINO MICE.

In the present study an attempt has been made to explore radiation and cadmium induced histological alterations in mice liver and their modulation by Emblica officinalis fruit Extract (EOE). For this purpose mice were selected from Inbred colony and divided into five different groups. Group: Ι (Sham-irradiated group) considered as normal; II (cadmium chloride treated group) in this group animals ...

S. L. Bhati, M. Agarwal, A. Chakrawarti and R. K. Purohit *

Radiation Biology Laboratory, Department of Zoology, Govt. Dungar College, Bikaner, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).370-76

370-376

1954

737

48.

PATTERN AND DETERMINANTS OF OVERWEIGHT AND OBESITY AMONG MEDICAL STUDENTS OF KOLKATA

Introduction: Researchers have shown variable prevalence of overweight & obesity among medical students. Aim: To assess the prevalence & determinants of overweight/obesity among undergraduate medical students. Methods: A cross sectional study was carried out among 278 medical students at Kolkata from March 2015 up to May 2015 by filling a pre designed, pre tested structured questionnaire a...

M. Basu *, K. Sarkar, B. Shahbabu , S. Ray, G. Barik, S. Chatterjee and R. N. Misra

Department of Community Medicine, Faculty of Community Medicine, IPGME & R, 244 AJC Bose Road, Kolkata, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.7(1).377-86

377-386

2801

826

49.

A CASE REPORT ON ATROPINE INDUCED PSYCHOSIS

The administration of atropine to a large population for treatment of intoxication carries the risk of allergic or toxic reactions in a small number of patients. It has been reported rarely in the literatures .We describe a cases of atropine-induced psychotic disorder in a substance abused patient and different approaches of management. Dryness of the mouth, blurred vision, photophobia and tach...

Neethu Ros Tom, Greeshma Hanna Varghese, Hanna Alexander, Swethalekshmi. V, T. R. Ashok Kumar and T. Sivakumar

Department of Pharmacy Practice, Nandha College of Pharmacy, Erode, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(1).387-91

387-391

8567

1883

50.

CHEMICAL COMPOSITION OF THE ESSENTIAL OIL FROM THE LEAVES OF CIPADESSA BACCIFERA (ROTH.) MIQ.

Cipadessa baccifera (Roth.) Miq. of Meliaceae family, is an ethnobotanically important plant and is widely used in folklore medicine for treating a range of maladies including diabetes, dysentery, malaria, rheumatism, piles, head ache, and psoriasis. The present study was aimed at investigating the essential oil composition from the leaves of C. baccifera. The essential oil was extracted through h...

K. R. Kavitha *, A.K. Bopaiah and Amzad Basha Kolar

Research & Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(1).392-96

392-396

2526

973

51.

EFFECT OF NITROGEN, PHOSPHORUS CONCENTRATIONS, pH AND SALINITY RANGES ON GROWTH, BIOMASS AND LIPID ACCUMULATION OF CHLORELLA VULGARIS

Microalgal like Chlorella vulgaris, being a unicellular green algae, is been widely studied for nitrogen and phosphorus removal and as potential feedstock for biodiesel production. This not only saves water from eutrophication but also becomes a good source of biodiesel.  Hence, if two approaches are combined we can overcome the major challenge of both eutrophication and energy crisis. In the pre...

Neha Kalla* and S. Khan

Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.7(1).397-05

397-405

3755

1096

52.

EFFECT OF CHEWING FENNEL AND CARDAMOM SEEDS ON DENTAL PLAQUE AND SALIVARY pH – A RANDOMIZED CONTROLLED TRIAL

Objectives: To know the effects of chewing the fennel and cardamom seeds on plaque and salivary pH. Materials and Methods: 50 subjects (aged 18-60 years) attending V.S dental College and Hospital who gave consent to participate were recruited for this clinical study. Subjects were randomized in to two groups for chewing fennel and cardamom seeds. Salivary pH and plaque PH at baseline and immediate...

Swathi V. , Rekha R. , Abhishek Jha , G. Radha , S. K. Pallavi and Gadde Praveen

Department of Public Health Dentistry, V S dental College and Hospital, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(1).406-12

406-412

8967

1196

53.

COMBINATIONAL THERAPY OF ROSUVASTATIN CALCIUM AND FENOFIBRATE AS BILAYER TABLET: A POTENTIAL APPROACH TO CONTROL HYPOLIPIDAEMIA

The present investigation studied a novel bilayer tablet having extended release of rosuvastatin calcium (RSTCa) and immediate Release of fenofibrate (FB) in different polymers using wet granulation techniques. Granules were characterized by fourier-transformed Infrared Spectroscopy (FT-IR), differential Scanning Calorimetry (DSC), as well as by content uniformity, in-vitro dissolution studies and...

Lokesh Kumar *, M. Vijay Kumar and Gaurav Tiwari

Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(1).413-28

413-428

3831

1210