Pages Menu
TwitterRssFacebook
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

Categories Menu

Volume 7 (2016) - Issue 2, February

Review Articles

 
Title
Views
PDF
Cited
1.

POMEGRANATE SEED OIL: A COMPREHENSIVE REVIEW ON ITS THERAPEUTIC EFFECTS

Pomegranate, Punica granatum L. (Punicaceae), as a medicinal and nutritional ancient fruit, has an outstanding medical history throughout the world. Each of compartments of pomegranate has interesting pharmacological activity. Juice, leaf, flower, and peels of pomegranate possess potent antioxidant properties, while juice, peel and oil are all weakly estrogenic activity. Pomegranate seeds have eth...

Mohammad Taher Boroushaki, Hamid Mollazadeh *and Amir Reza Afshari

Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: 10.13040/IJPSR.0975-8232.7(2).430-42

430-42

10439

1734

2.

SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A LIPID BASED DRUG DELIVERY SYSTEM

Administration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipid b...

Seema Pattewar *, Sanjay Kasture, Vishal Pande and Swapnil Sharma

Department of Pharmacy, Banasthali University, Banasthali, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(2).443-52

443-52

6514

1438

3.

A REVIEW ON OSMOTIC PUMP DRUG DELIVERY SYSTEM

Drug release from novel drug delivery systems are desired to be controlled at target site in effective concentration for required therapeutic action with predictable plasma concentrations, unlike conventional ones, thereby reducing the dose, dosage frequency, toxic adverse effects, reduction of blood level fluctuations, improved patient compliance and minimization of drug accumulation. As this can...

M. Mathur * and R. Mishra

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmadabad, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(2).453-71

453-71

12919

1837

4.

A REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL RESEARCH – REMEDY FOR SICKLE CELL DISEASE

Aim: This article focuses on the current review of world-wide medicinal plants studied for their phytochemical investigations, various biological activities and clinical studies in relation to their use for treatment of Sickle cell disease. Method: All relevant literature databases were searched up to 18 September 2014. The search terms were plant, herb, herbal therapy, phytotherapy, sickle cell a...

Shilpa Vaishnava * and V. D. Rangari

SLT Institute of Pharmaceutical Sciences Guru Ghasidas Vishwavidyalaya, Bilaspur Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).472-81

472-81

9489

1321

5.

COUMARINS: AN OVERVIEW OF MEDICINAL CHEMISTRY. POTENTIAL FOR NEW DRUG MOLECULES

Fusion of a pyrone ring with a benzene nucleus gives rise to a class of heterocyclic compounds called Benzopyrones, of which two distinct types are recognized:  (1) benzo-α-pyrone commomly called coumarins and   (2) benzo-ϒ-pyrone called chromones or flavanoids, latter differing from former only in the position of the carbonyl group in heterocyclic system. Coumarins have attracted considerabl...

Divya Singh*, Dharam Pal Pathak and Anjali

Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Sciences Research University, Pushp Vihar, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.7(2).482-04

482-04

6876

1583

6.

PHYTOCHEMISTRY AND MEDICINAL ATTRIBUTES OF A. SCHOLARIS: A REVIEW

The plant Alstonia scholaris has been used in different system of traditional medicine for the treatment of diseases. The extract of the plant showed pharmacological activities ranging from anti-malarial to anticancer properties. Alstonia scholaris is such plant who have medicinal activity against many of the ailments. In recent times, there is an upsurge of interest and focus on the importance of...

Pooja Sharma, Rajiv Sharma, H. S. Rao and Dinesh Kumar *

Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).505-13

505-13

4003

772

7.

THE LANDSCAPE OF THERAPEUTIC CANCER VACCINE

Cancer vaccines, a unique approach to cancer therapy are the propitious tools in the hands of the clinical oncologist. Immunization with these specific cancer vaccines put forth an antitumor effect by captivating the host immune response, and has immense prospective for avoiding the inherent drug resistance that confines typical cancer management. Strategies to attain affirmative clinical conseque...

Bhrigu Kumar Das* and Jayamma M Kulkarni

Department of Pharmacology, K.L.E.U’s College of Pharmacy, Hubli, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(2).514-19

514-19

2305

826

8.

ROLE OF AYURVEDAIN MANAGEMENT OF LEUKEMIA (RAKTARBUDA)

The abnormal growth of White Blood Cell in the bloods and bone marrow is called as Leukaemia. Leukaemia is the 11th most common cancer worldwide. Leukaemia is not a new disease for Ayurveda, which is mentioned under the heading of Raktarbud respectively. The mutations of any carcinogens are the first causative factor of abnormal growth of cancerous cell including Leukaemia. Accordingly to Ayurveda...

Monika Sharma* and Sharad Maroti Porte

P.G. Department of Agad Tantra, National Institute of Ayurveda Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(2).520-30

520-30

14170

1167

9.

QUANTIFICATION OF FLUOROQUINOLONES FROM BULK, PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL MATRICES USING CHROMATOGRAPHIC TECHNIQUES

Fluoroquinolones are the most commonly prescribed synthetic antibacterial agents having improved pharmacokinetic properties and broad spectrum of activity. Due to their broad clinical activity they are the most promising drug for antibacterial chemotherapy. The current study focused on the application of similar chromatographic system for the analysis of a number of fluoroquinolones from bulk, pha...

Amit Kumar De, Ashok Kumar Bera and Biswajit Pal *

Department of Chemistry, St. Paul’s C. M. College, Kolkata, West Bangal, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).531-42

531-42

2293

783

10.

AN UNDERSTANDING OF PULSATING DRUG DELIVERY SYSTEM – A REVOLUTIONARY APPROACH IN PHARMACEUTICAL SCIENCE

Pulsatile drug delivery systems (PDDS) have attracted attraction because of their multiple release system. Pulsatile drug delivery systems are the new approach to overcome patient non-compliance over commercially used dosage forms. These techniques also help in treating the disorders based on circadian paradigm and the drugs are rapidly released according to the lag time decided by the carrier med...

R. Taneja and G. D. Gupta *

Department of Pharmaceutical Research Div. ASBASJSM College of Pharmacy, Ropar, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(2).543-53

543-53

2190

906

Research Articles

 
Title
Views
PDF
Cited
11.

3D-QSAR AND CONTOUR MAP ANALYSIS OF TARIQUIDAR ANALOGUES AS MULTIDRUG RESISTANCE PROTEIN-1 (MRP1) INHIBITORS

One of the major obstacles to the successful chemotherapy towards several cancers is multidrug resistance of human cancer cells to anti-cancer drugs. An important contributor to multidrug resistance is the human multidrug resistance protein-1 transporter (MRP1), which is an efflux pump of the ABC (ATP binding cassette) superfamily. Thus, highly efficacious, third generation MRP1 inhibitors, like t...

P, Kakarla, M. Inupakutika, A. R. Devireddy, S. K. Gunda, T. M. Willmon, Ranjana KC , U. Shrestha, I. Ranaweera, A. J. Hernandez, S. Barr, And M. F. Varela٭

Department of Biology, Eastern New Mexico University, Station 33, Portales, NM, 88130,USA

DOI: 10.13040/IJPSR.0975-8232.7(2).554-72

554-72

4435

850

12.

EVALUATION OF SUB-CHRONIC TOXICITY AND HEAVY METAL TOXICITY OF KAPPAPHYCUS ALVAREZII IN- VIVO

Seaweed consumption is becoming more popular in Asian population especially the red seaweed, Kappaphycus alvarezii (K. alvarezii). However, there are few reported studies on the safety of K. alvarezii for consumption in Malaysia. This study focuses on the in vivo evaluation of toxicity and heavy metals of K. alvarezii performed in albino rats. K. alvarezii were sent for heavy metal analysis while ...

Xin Qi Chuah and Swee Sen Teo*

Department of Biotechnology, Faculty of Applied Science, UCSI University Kuala Lumpur, Jalan Menara Gading, UCSI Heights, Cheras, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.7(2).573-78

573-78

3953

857

13.

IN-VITRO EFFECTS OF PARACETAMOL ON RHEOLOGICAL PROPERTIES OF ERYTHROCYTES AND ITS ANTIOXIDANT PROPERTIES

Human erythrocytes were pre-incubated in vitro with paracetamol and then erythrocyte’s rheological properties of deformability, osmotic fragility and aggregation were evaluated after being compromised by various means. Paracetamol (1, 2, 4mg/ml) significantly prevented the loss of deformability through 5mm diameter pores of erythrocytes dehydrated with hypertonic buffer or with calcium ionophore...

Y.Y. Bilto

Department of Biological Sciences, The University of Jordan, Amman, Jordan

DOI: 10.13040/IJPSR.0975-8232.7(2).579-86

579-86

3696

806

14.

AVAILABILITY AND AFFORDABILITY OF ESSENTIAL ANTIBIOTICS FOR PEDIATRICS IN SEMI-RURAL AREAS IN TANZANIA

In this study, we assessed the availability, cost and affordability of essential antibiotics for paediatrics in a semi-rural region in Tanzania. Data were collected from 1 Medical Stores Department (MSD), 8 public hospitals, 30 Private Pharmacies and 30 Accredited Drug Dispensing Outlets (ADDO`s). The median price of tracer medicines and average stock-out days of per year were used to assess the c...

Appolinary A.R. Kamuhabwa* and Kabandika Twaha

Unit of Pharmacology and Therapeutics, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

DOI: 10.13040/IJPSR.0975-8232.7(2).587-00

587-00

3730

762

15.

EFFECT OF COMPACTION PROCESS IN GRANULOMETRY

Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The aim of the present study is to evaluate the effect of manufacturing process on critical quality attribute on In-process parameters (Granules). Quetiapine fumarate was selected as a model drug for sustained release drug delivery system manufactured ...

Himankar Baishya*, Shirley Thomas, Vivekanand Verma and Libin

Formulation Development Department, Beijing Sciecure Pharmaceuticals Co., Ltd., Beijing, China

DOI: 10.13040/IJPSR.0975-8232.7(2).601-06

601-06

3994

920

16.

SYNTHESIS AND BIOLOGICAL EVALUATION OF MARUMOSIDE A ISOLATED FROM MORINGA OLEIFERA AND ITS LIPID DERIVATIVES

In the present study, Marumoside A isolated from Moringa oleifera, a traditional medicinal plant, was synthesized for the first time using trichloroacetimidate donor as a key step. The aglycone 4-hydroxy phenylacetamide was prepared from 4-hydroxyphenyl acetic acid using oxallyl chloride and aqueous ammonia. The lipid derivatives of Marumoside A were synthesized using different fatty amines. The a...

S. Vudhgiri, Prasad R. B. N., A. Kota, Poornachandra Y. , G. Kumar C, R. Sistla and R. C. Reddy Jala *

Centre for Lipid Research , CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).607-17

607-17

1923

702

17.

OLEANANE-TYPE TRITERPENOID SAPONIN OF MOMORDICA CYMBALARIA EXHIBITS NEUROPROTECTIVE ACTIVITY IN DIABETIC PERIPHERAL NEUROPATHY BY AFFECTING THE POLYOL PATHWAY

Momordica cymbalaria Fenzl (Cucurbitaceae) fruit powder and extracts are reported to have Type 1 antidiabetic activity in experimental diabetic models. The objective of this study was to investigate the neuroprotective action of an oleanane-type triterpenoid saponin isolated from the plant in diabetic peripheral neuropathy (DPN) by in vivo and in vitro methods. Male Wistar rats were rendered diabe...

Suman Samaddar *, Raju Koneri Balwanth, Abhinaya Bhattarai and K. B. Chandrasekhar

Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(2).618-25

618-25

1639

552

18.

FORMULATION AND CHARACTERISATION OF SUSTAINED RELEASE CARVEDILOL TABLET FROM RESERVOIR PELLETS

Sustained release Carvedilol tablets constituting reservoir pellets developed in this study is an attempt to investigate the effect of drug release from matrix. The sustained release Carvedilol tablets were prepared by using different combination with release modifier (ethyl cellulose 10 cps and Eudragit RS 100). Tablets containing disintegrant pellets (Crosspovidon) with active ingredient demonst...

Amit M. Gupta* and U.D. Shivhare

Department of Pharmaceutics, Sharad Pawar College of Pharmacy, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(2).626-34

626-34

2660

689

19.

A NEW SINGLE STABILITY INDICATING RP-ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY (RP-UPLC) METHOD FOR EVALUATION OF ASSAY OF BICALUTAMIDE FROM DOSAGE FORM AND SUITABILITY OF METHOD FOR DETERMINATION OF DISSOLUTION RATE AND RESIDUE ANALYSIS.

A new single stability-indicating isocratic reversed phase ultra-performance liquid chromatographic (RP-UPLC) method with a shortest run time of 2.5 minutes is developed for the determination of assay of bicalutamide an anti-cancer drug from its finished dosage form in the presence of its forced degradation products. The method is developed using Waters Aquity BEH C18 column with mobile phase cont...

Vamsi Krishna Galla, Archana V. and Rajeswari Jinka

Department of Biochemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).635-45

635-45

1873

608

20.

ROLE OF THE INCRETINS IN HYPOGLYCEMIC EFFECT OF PHLOGACANTHUS THYRSIFLORUS NEES IN CHEMICALLY INDUCED DIABETIC MICE

Objective: This study was aimed to evaluate the role of GLP-1, GIP in the hypoglycemic activity of Phlogacanthus thyrsiflorus Nees. Materials and Methods: We have evaluated the influence of Phlogacanthus thyrsiflorus Nees, a traditionally used antidiabetic medicinal plant on some metabolic parameters, glucose homeostasis, insulin production, glucagon like peptide 1 (GLP1) and gastric Inhibitory Po...

Sharmistha Chakravarty * and Jogen Ch. Kalita

Department of Zoology, Gauhati University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).646-59

646-59

1605

699

21.

STUDIES ON HISTOLOGICAL AND HISTOPATHOLOGICAL MYCOSIS VARIATIONS OF CHANNA STRIATUS (BLOCH) FOUND INFECTED WITH ASPERIGILLUS FUMIGATUS AND ASPERGILLUS NIGER SPP.CAUSED EUS CHARECTERSTICS.

The present investigation deals with the histological and histopathological altarations in Channa striatus infected with fungi Aspergillus fumigates and Aspergillus niger. Fresh water murrels were collected from Dharmasagar and Hasanparthy lakes and Local fish markets of Warangal district. This is due to the nature of their habitats as many native species of fish suffer from living beneath turbid ...

Koteshwar Rao Podeti * and Benarjee G

Fisheries Research Laboratory, Department of Zoology, Kakatiya University, Warangal, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(2).660-65

660-65

2290

767

22.

SYNTHESIS AND CHARACTERIZATION OF [16]- MEMBERED DIOXA DIAZA NAPTHALDEHYDE BASED MACROCYCLIC LIGAND AND ITS COMPLEXES OF Co(III), Ni(II) AND Cu(II) PERCHLORATE IONS

An hitherto new unreported  [16]-membered dioxadiazanapthaldehyde based macrocyclic ligand (L) 2,11-dioxa-23,30-diaza heptacyclo [30.4.0.04,9.012,21.014,19.024,29.034,39] -tetraconta-12,14,16, 18,20,22, 24,26,28,30,32,34,36,38,40-pentadecaene, has been synthesized by two different synthetic routes each involving two stages. 2-Hydroxy-1-Napthaldehyde in the presence of potassium carbonate was trea...

L. Rakesh Sharma, K. N. Sabharwal and A. N. Paul Angelo *

Department of Chemistry, St. Joseph's College (Autonomous), Tiruchirappalli, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(2).666-74

666-74

1621

677

23.

ANTIDIABETIC ACTIVITY OF PIPER BETLE IN ALLOXAN INDUCED TYPE 1 DIABETIC MODEL RATS

The aim of this study was to investigate the potential antidiabetic activity of Piper betle in alloxen induced diabetics. Rats were divided into 6 groups and Piper betle was administered containing 50, 100 and 200 mg/kgbwt powder, respectively in 1ml water orally in group A, B and C rats. Metformin (150 mg/kgbwt) used as a reference standard drug. Blood glucose (BG), triglycerides (TG), total chol...

Mst. Monira khatun, Md. Ashrafuzzaman Sapon, Md. Shamim Hossain ∗ and Md. Rezuanul Islam

Department of Biotechnology and Genetic Engineering , Faculty of Applied Science and Technology, Islamic University, Kushtia, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(2).675-80

675-80

2585

848

24.

PHYSICOCHEMICAL CHARACTERIZATION OF  – CYCLODEXTRIN COMPLEXES OF TAMOXIFEN CITRATE AND PHASE SOLUBILITY STUDIES

The objective of the present investigation is to study the possibilities to improve the aqueous solubility and dissolution rate of Tamoxifen citrate (TC) – an oral anticancer drug, based on inclusion complexes with a– cyclodextrin (α –CD). The inclusion processes are discussed based on absorption, emission, FT-IR, 1H-NMR, SEM and phase solubility study. The α –CD study shows that the dru...

G. Mary Metilda * and J. Prema Kumari

Department of Chemistry, CSI Institute of Technology, Thovalai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(2).681-88

681-88

2713

709

25.

IDENTIFICATION OF AEROTOLERENCE GENE BATA AND BATB IN SUBGINGIVAL MICROFLORA: AGGREGATIBACTER ACTINOMYCETEMCOMITANS, TANNERELLA FORSYTHIA AND PREVOTELLA INTERMEDIA

Subgingival obligate anaerobes present within the biofilm such as Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia and Aggregati bacter actinomycetemcomitans have been implicated in the initiation and progression of periodontal disease. Recent documentation has demonstrated that P.gingivalis is capable of maintaining its viability when exposed to oxidative stress by expressing...

H. Parthsarathy, R. Gad and C. A. Jacob *

Department of Periodontology, Saveetha Dental College, Chennai, TN, India

DOI: 10.13040/IJPSR.0975-8232.7(2).689-96

689-96

1553

630

26.

FORMULATION AND INVITRO EVALUATION OF BUDESONIDE MICROSPHERES FOR COLON TARGETING

Microspheres are one of the drug delivery systems used to target drug at the desired site. The objective of the present study was to prepare, characterize and evaluate colon targeted microspheres of budesonide for the treatment of ulcerative colitis. Microspheres were prepared by ionotropic gelation process using tripolyphosphate as cross- linking agent. Budesonide containing chitosan microspheres...

D. Kala * and C. R. Sudhakaran Nair

College of Pharmaceutical Sciences, Govt Medical College, Thiruvananthapuram, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(2).697-02

697-02

2207

727

27.

EFFICACY OF SODIUM HYPOCHLORITE IN CONTROLLING BACTERIAL INFECTIONS IN FIFTH INSTAR LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)

Bacterial diseases are highly virulent and cause significant crop loss in Anthereae mylittadrury (Daba TV).Therefore an attempt has been made to evaluate the efficient concentration of sodium hypochlorite in controlling bacterial infection through studies on mortality, Total haemocytes, Protein carbonyl content, Alanine transaminase, Aspartate transaminase in the fifth in star larvae. Results reve...

Lakshmi Marepally * and G Benarjee

Department of Zoology, Kakatiya University, Warangal, Telengana, India

DOI: 10.13040/IJPSR.0975-8232.7(2).703-07

703-07

1841

648

28.

CELL PROLIFERATIVE ACTION OF HYDROALCOHOLIC EXTRACT OF TRIGONELLA FOENUM GRAECUM IN RATS

The healing of an adult skin wound is a complex process of different tissues and cell lineages. Understanding wound healing involves understanding of inflammation, proliferation, and maturation phase. The present study was aimed at evaluation of proliferative action of hydroalcoholic extract of Trigonella foenum graecum (HETG) in albino rats using excision and incision wound model. HETG 5% W/W and...

P. Muralidharan*, M. Thenmozhi and R. Prakash

Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(2).708-13

708-13

1773

537

29.

PRELIMINARY PHYTOCHEMICAL SCREENING AND PHARMACOLOGICAL EVALUATION OF THE LEAVES OF BUTEA MONOSPERMA

Various parts of the plant Butea monosperma have been used traditionally for many of the diseases like anti-inflammatory, antimicrobial, anthelmintic, antidiabetic, diuretic, analgesic, antitumor, anticancer, astringent activities. Among the various parts of the Butea monosperma first choice is selection of leaves in our current research work because only scanty work has been done on leaves. So it...

Manoj Kumar Mishra

Shambhunath Institute of Pharmacy, Jhalwa, Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(2).714-18

714-18

2931

872

30.

A VALIDATED HPLC METHOD FOR THE DETERMINATION OF BETULIN IN THE STEM BARK OF TECTONA GRANDIS LINN.

Betulin, a known pentacyclic tri-terpenoid, possessing diverse pharmacological properties was determined using HPLC in stem bark methanol extract of Tectona grandis Linn. distributed in greater part of India. Furthermore, Tectona grandis Linn. is used traditionally in treatment of bronchitis, dysentery, headache, leukoderma, leprosy and constipation. The present study was aimed to validate HPLC me...

Preet Amol Singh *, N. B. Brindavanam , G. P. Kimothi , Rajesh Verma and Vidhu Aeri

Department of Pharmacognosy and Phytochemistry, Jamia Hamdard University, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).719-23

719-23

2524

716

31.

METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF EMPAGLIFLOZIN IN API

An accurate, precise and rapid RP-HPLC method was developed and subsequently validated for the determination of Empagliflozin in API. Better separation of the drug was achieved on Intersil column(150x40mm, 5 μm) with the mobile phase consisted of mixture of  0.01 M acetate buffer, methanol in ratio of (30:70v/v ) at flow rate of 2ml/min, with detection at 260nm using PDA detector. The retention...

N. Padmaja and G. Veerabhadram *

Faculty of Pharmacy, University College of Technology, Osmaina University, Hyderabad, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).724-27

724-27

6156

1879

32.

ALTERATIONS IN PLASMA ANTIOXIDANT ENZYME LEVELS AND SERUM LIPID PROFILE PARAMETERS IN RELATION TO LIPID PEROXIDATION IN INDIVIDUALS WITH MATERNALLY INHERITED TYPE 2 DIABETES MELLITUS

Aim: The present study aimed to evaluate the antioxidant potential and lipid profile parameters, in relation to lipid peroxidation in patients with maternally inherited type 2 diabetes mellitus and in healthy normal individuals. Methods: All standard methods were used to estimate enzymatic antioxidants [Catalase, Copper containing Superoxide Dismutase (CuSOD), Manganese containing Superoxide Dismu...

Utpal J. Dongre and Virendra G. Meshram *

University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(2).728-37

728-37

2243

671

34.

IN-VITRO ANTIFUNGAL ACTIVITY OF LEAF EXTRACTS OF LEUCAS ASPERA AND LEUCAS ZEYLANICA

The aim of the present study is to probe the antimicrobial activities of methanol leaf extract of Leucas sp. Antifungal susceptibilities of certain clinically isolated dermatophytes to methanol extracts of Leucas aspera and Leucas zeylanica leaves were performed using agar well diffusion method. The result obtained shows that all the extracts expressed remarkable antifungal activity with zone of i...

A. Babu, M. Sheik Noor Mohamed, K. Jaikumar, D. Anand and P. Saravanan*

Department of Botany, Ramakrishna Mission Vivekananda College, Chennai , Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(2).752-56

752-56

3439

1006

35.

A CLINICAL TRIAL TO ASSESS THE ANTIDIABETIC, ANTIDYSLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF TINOSPORA CORDIFOLIA IN MANAGEMENT OF TYPE – 2 DIABETES MELLITUS

The present study was carried out to explore anti-diabetic, antidyslipoproteinemic and anti oxidant activities of Tinospora cordifolia (Menispermaceae) in type 2 diabetic patients. In this study clinical trial was conducted on type 2 diabetic patients attending the diabetes OPD, at Kaya Chikitsha Vibhag, Rajkiya Ayurvedic Chikitsha Mahavidyalaya, Touriya Ganj, Lucknow, following all ethical guide ...

Vishnu Kumar *, Farzana Mahdi, Ranjana Singh, Abbas Ali Mahdi and Raj Kumar Singh

Department of Biochemistry, Era’s Lucknow Medical College & Hospital Lucknow, UP, India

DOI: 10.13040/IJPSR.0975-8232.7(2).757-64

757-64

2207

661

36.

THE EFFECT OF DOXYCYCLINE HYDROCHLORIDE ON MMP-2 AND 9 IN EXPERIMENTALLY INDUCED PERIODONTITIS – AN ANIMAL STUDY

The periodontal tissues undergo constant changes of remodelling when subject to bacterial infection and the resultant host response. The balance between enzymes secreted by the host such as matrix metalloproteinases (MMPs) and their antagonists tissue inhibitor of metalloproteinases (TIMPs) are major contributors to the progression of periodontal destruction. A sub-type of MMPs referred to gelatin...

H. Parthsarathy, S. Aishwarya and C. A. Jacob *

Department of Periodontology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai - 600089, TN, India

DOI: 10.13040/IJPSR.0975-8232.7(2).765-72

765-72

1689

753

37.

PHARMACOGNOSTICAL AND PHYSICO-CHEMICAL STANDARDISATION OF WHOLE PLANT OF ADIANTUM CAPILLUS VENERIS LINN

Traditional knowledge and ethno-botanical use of plants have been widely acknowledged all over the world. The cicatrizing properties of extracts obtained from this plant have been scientifically studied, attributing the main biological activity to its tannin and flavonoid content. Recent commercialization of the plant drug Adiantum capillus veneris Linn. requires pharmacognostical information to d...

Vadi Ranjan* and Manisha Vats

G.V.M College of Pharmacy, Sonepat, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(2).773-82

773-82

2674

678

38.

DEVELOPMENT OF ELECTROCHEMICAL BIOSENSOR FOR DETECTION OF ASPARAGINE IN LEUKEMIC SAMPLES

Acute Lymphoblastic Leukemia (ALL) is one of the deadly diseases among children causing a number of deaths worldwide. It could be treated using chemotherapy, bone marrow transplantation or irradiation therapy but it may cause side-effects. Therefore, interest has arisen in the use of plants for treatment of ALL. Cannabis sativa is known to produce L-asparaginase which is used to treat ALL. L-aspar...

Pathak Teena, Kaur Jagjit, Kumar Raman and Kuldeep Kumar *

Department of Biotechnology, Multani Mal Modi College, Patiala, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(2).783-88

783-88

2171

722

39.

EFFECTS OF STREPTOZOTOCIN- INDUCED TYPE I DIABETES MELLITUS ON CATION CONTENTS IN URINARY BLADDER TISSUES OF THE RAT

Diabetes mellitus is known to induce microvascular changes and alterations to neuronal functions. Diabetic neuropathy and diabetic nephropathy are two of the major long-term complications of diabetic mellitus (DM). The main aim of the comparative study is to investigate the role of cations contents compared to the age matched control.Adult rats were humanely killed and detrusor muscles of urinary ...

V. C. Sangar * and J. Singh

Department of Virology, Haffkine Institute for Training Research and testing, Parel, Mumbai, Maharashtra India.

DOI: 10.13040/IJPSR.0975-8232.7(2).789-97

789-97

1740

546

40.

FIRST REPORT ON EVALUATION OF ANTI-DIABETIC POTENTIAL OF CHITIN AND CHITIN-BASED DERIVATIVES AGAINST ALLOXAN INDUCED ALBINO RATS

Crustacean’s shells constitute the traditional and current commercial source of Chitin. These derivatives/molecules are potential resource as well as multiple functional substrates have generate attractive interest in various fields such as biomedical, pharmaceutical, food and environmental industries. In the present investigation, chitinous wastes were collected from the fresh water areas of De...

Junaid Alam * and Abhishek Mathur

Department of Biotechnology, Himalayan University, Arunachal Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(2).798-03

798-03

1885

679

41.

ISOLATION AND PURIFICATION OF A GALACTOSE SPECIFIC LECTIN FROM SEEDS OF BAUHINIA VARIEGATA AND EVALUATION OF ITS ANTIMICROBIAL POTENTIAL

A galactose-specific lectin was purified from seeds of a leguminous plant, Bauhinia variegata, by affinity chromatography on lactose–agarose. Protein extract agglutinated human erythrocytes (treated with proteolytic enzyme). Among various carbohydrates tested, the lectin was best inhibited by D-galactose and other sacharides. SDS-PAGE showed that the lectin, named BVL produce a single band estab...

Ravi Prakash Mishra*, Aijaz Ahmad Ganaie and Aashiq Hussain Allaie

Environmental Biotechnology Lab, Department of P.G Studies and Research in Bioscience, R.D. University, Jabalpur, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(2).804-09

804-09

2149

746

42.

FORMULATION AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM AND ITS DELIVERY BY PASSIVE AND INOTOPHORESIS METHOD: A COMPARATIVE STUDY

The objective of present study was to develop Lornoxicam transdermal gel and its iontophoretic delivery to enhance its permeation for systemic effect and to avoid its side effects. Lornoxicam is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain, edema and rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, carbopol 934P as gel ...

Ankit Acharya, Pramod Dhakal* and Diwakar Khadka

Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B. G. Nagara - 571448, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(2).810-18

810-18

3307

774

43.

STANDARDIZATION OF ASHWAGANDHA GHRITA: A HERBAL GHEE BASED AYURVEDIC MEDICINAL PREPARATION

Background: The WHO assembly in number of resolutions has emphasized the need to ensure quality control of medicinal plant products by using modern techniques and applying suitable standards. Since Ayurvedic medicines come under the purview of Drugs and Cosmetics Act, there is increased general awareness about the necessity for developing standards for the purpose of quality control by the manufac...

Deepthi Viswaroopan* Arun Raj GR and Shailaja U

Department of Kaumarabhritya, SDM College of Ayurveda and Hospital, Hassan - 573201, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).819-23

819-23

3512

962

44.

ANTI-DIABETIC PROFILE OF CINNAMON POWDER EXTRACT IN EXPERIMENTAL DIABETIC ANIMALS

Objective: to investigate the anti diabetic effect of ethanolic extract of Cinnamomum zeylanicum on Alloxan induced diabetes in experimental animals (Rats). Materials and Methods:  the alcohol extract of Cinnamomum zeylanicum was tested for its efficacy in Alloxan (150mg/kg) induced diabetic rats. The diabetic rats were divided into 5groups. Group I (control) received 2% gumacasia, groupie (posit...

Pusuloori Rajesh, S. Sharon Sonia, Y. Vijayabhaskara Reddy and M. Shiva Kumar

Pharmacology of Kurnool Medical College. Kurnool. A.P., India.

DOI: 10.13040/IJPSR.0975-8232.7(2).824-28

824-28

2301

730

45.

RHIZOME ESSENTIAL OIL COMPOSITION OF ZINGIBER CERNUUM AND ITS ANTI MICROBIAL ACTIVITY

Zingiber cernuum belongs to family Zingiberaceae is a perennial herb, also called as Curved stem ginger. The rhizomes of Zingiber cernuum is steam distilled and the composition of essential oil was studied. The essential oil obtained was yellow in colour and the yield was about 0.007%. The chemical profile of the oil was obtained from their GC-MS analysis. The major components present in the oil a...

Mity Thambi * and Mohamed P. Shafi

Department of Chemistry, Catholicate College, Pathanamthitta, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(2).829-33

829-33

1832

625

46.

A SIMPLE AND SENSITIVE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF TRACE LEVEL MONO ISOPROPYLAMINE IN PHARMACEUTICAL DRUG SUBSTANCES

A simple and sensitive spectrophotometric method was developed and optimized for the determination of content of mono isopropylamine at very low levels in Carisoprodol and Isoproterenol hydrochloride. The method was based upon the observation, that characterstic colour results up on addition of colour reagent (consists of Acetyl acetone, formaldehyde and pyridine) and heat for 10 minutes on water ...

C. Nagaraju *, R. Gorla, U. K. Ray, N. Kanteti, Hemant K. Sharma and S. Vidavalur

APL Research Centre-II(A Division of Aurobindo Pharma Ltd), Indrakaran(V), Sangareddy (M), Medak Dist., Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(2).834-39

834-39

2420

887

47.

TO INVESTIGATE THE EFFECTS OF GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) ON AMPHETAMINE-INDUCED LOCOMOTOR ACTIVITY IN RAT

To investigate the effects of ginger-juice (Zingiber officinale roscoe) on amphetamine-induced locomotor activity in rat. Methods: (A) Albino rats (n=6-12) were administered G.J at the single doses (4 ml/rat, p.o) as single administration (acute) and chronic treatment over period of 7 days. Following this assessment was done. Effect of treatment with G.J acutely and chronically (7days) administere...

S. S. Prasad *, R. R. Pathak, S. K. Vajpeyee and V. H. Bhavsar

Department of Pharmacology, GMERS Medical College, Gandhinagar, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(2).840-46

840-46

1530

668

48.

EFFECT OF DIFFERENT WAVELENGTHS OF LIGHT ON THE GROWTH OF CHLORELLA PYRENOIDOSA

Chlorella pyrenoidosa is a fresh water microalgae used as substrate for production of value added products like biodiesel. In this investigation C.pyrenoidosa was grown for ten days in an internally illuminated bubble column photobioreactor at:  450 lux green light (495–570 nm), 480 lux red light (620–750 nm), 1663 lux blue light (450–495 nm), 1986 luxwhite light (380 to 750 nm).The results...

Mounica Asuthkar, Yamini Gunti, Ramgopal Rao S, C S Rao and Rajasri Yadavalli *

Department of Biotechnology, Sreenidhi Institute of Science and Technology, Yamnampet, Ghatkesar, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(2).847-51

847-51

3025

775

49.

EVALUATION OF ANTI-OXIDANT PROPERTIES OF WHEAT GRASS POWDER AS AFFECTED BY DIFFERENT DRYING PROCESSES

Wheatgrass is one grass that has been demonstrated to be of particular use to humans as a nutritional source of vitamins, enzymes, minerals, trace minerals and chlorophyll in addition to its various health benefits. Wheat grass in powder form is a method for preserving wheat grass nutrients with long shelf life and use of wheat grass powder is more convenient than wheat grass juice. Objective: To ...

Pallavi Singh

Junior Research Fellow, Department of Foods and Nutrition, Ethelind School of Home Science, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(2).852-55

852-55

2951

657

50.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTIFICATION OF BETULINIC ACID IN VITEX NEGUNDO L. AND ITS POLYHERBAL FORMULATIONS

The Vitex negundo, which is traditional Indian medicine, has been used for treatment of various diseases. A simple, sensitive, precise and accurate RP-HPLC method has been developed for the analysis of Vitex negundo L. samples and its polyherbal formulations for their Betulinic acid content. The extraction was checked using different solvents like methanol, chloroform, 95% ethanol, acetone and dic...

R. K. Patel* and P. D. Trivedi

Department of Pharmaceutical Analysis, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.7(2).856-61

856-61

2241

663

51.

DRUG UTILIZATION EVALUATION OF ANTI-HYPERTENSIVE AGENTS IN A MEDICAL CARE HOSPITAL

Blood Pressure (BP) is defined as the product of the cardiac output (CO) and Total Peripheral Resistance (TPR).Hypertension is defined by persistent elevation of arterial blood pressure. Any drug that is indicated for decreasing/normalizing the elevated blood pressure is considered as an Anti-Hypertensive drug. Objective: To assess the utilization pattern of anti-hypertensive agents in the General...

Zahra Eslampanah

Department of Pharmacy Practice, The Oxford College of Pharmacy, Rajiv Gandhi University of Health Science, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(2).862-67

862-67

3171

813

52.

THE CLINICOPATHOLOGICAL PROFILE IN PATIENTS WITH EPITHELIAL OVARIAN CARCINOMA

The malignant tumors of ovary are a group of disease with varying clinical and biological behavior. It is fifth leading cause of death from cancer in women and the leading cause of death from gynecological cancer. This retrospective study has been undertaken to analyze patients of epithelial ovarian cancers. These cases were analyzed for various features like age, stage at presentation, histologic...

Paramjeet Kaur, Anil Khurana, Ashok Chauhan and Gajender Singh*

Department of Radiotherapy, Regional Cancer Centre and Pathology, Pt. B D Sharma, PGIMS, Rohtak, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(2).868-72

868-72

1724

554

53.

COMPARATIVE ANALYSIS OF DRUG-INDUCED PARKINSONISM LIKE BEHAVIORS IN C57BL6 BLACK MICE USING A FORCE PLATE ACTIMETER.

This study aims to compare the Parkinsonism behavior induced by two drugs: Tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride hydrate and MPTP (1-methyl, 4-phenyl 1,2,3,6 tetrahydropyrolidine) using a Force Plate Actimeter (FPA). 25 C57BL/6 black mice were equally divided into two groups for 5mg/kg tacrine and 30mg/kg MPTP experiment. Both groups contained sham, 5mg/kg tacrine or 30mg/...

Stuti Shrestha , Srichan Phornchirasilp and Krittiya Thisayakorn *

Pharmaceutical and Natural product Department , Thailand Institute of Scientific and Technological Research (TISTR), PathumThani, Thailand

DOI: 10.13040/IJPSR.0975-8232.7(2).873-81

873-81

1850

704