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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Volume 11 (2020) - Issue 6, June

Review Articles

 
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1.

AN UPDATED REVIEW ON INVASIVE NATURE, PHYTOCHEMICAL EVALUATION, & PHARMACOLOGICAL ACTIVITY OF AGERATINA ADENOPHORA

Ageratina adenophora, often known as Crofton Weed, is one of the common invasive weeds which first originated from Mexico and Central America and gradually invaded numerous parts of the world. Because of its ability to alter the soil microbial communities and its allelopathic competition with other plant species, this plant colonizes forest margins, stream banks and disturbed areas in large dense ...

R. Poudel, N. P. Neupane, I. H. Mukeri, S. Alok and A. Verma *

Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, SIHAS, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2510-20

2510-2520

1240

731

3.

PIM-1 KINASE: A NOVEL TARGET FOR CANCER CHEMOTHERAPY- A REVIEW

Cancer is the major cause of mortality in most of the developing countries. Recent times have seen an exceptional advancement in cancer biology Research. Researchers undertook the development of enormous chemotherapeutic agents. Pim family of serine/threonine kinases regulated by calcium/calmodulin have been identified as unique molecular targets in oncogenesis. It constitutes three members: Pim-1...

P. S. Harshita, P. S. Yasaswi, V. Jyothi and T. S. Jyostna *

Department of Pharmaceutical Chemistry, Sarojini Naidu Vanita Pharmacy Mahavidyalaya, Tarnaka, Secunderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2528-38

2528-2538

1221

777

4.

SCREENING MODELS OF LAXATIVE ACTIVITY

Substances that loose stools and boost bowel movements are laxatives, purgatives, or aperitives. They are used to treat constipation and to stop it. Constipation relates to infrequent or difficult to transfer bowel movements. Often the stool is hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if the bowel movement has not been fully passed. Hemorrhoid's anal fissur...

S. Kadam, P. Gupta and V. G. Kanase *

Department of Pharmacology, Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2539-46

2539-2546

627

239

5.

A REVIEW ON RECENT TRENDS AND FUTURE PERSPECTIVES OF IONTOPHORESIS ASSISTED OCULAR DRUG DELIVERY

Iontophoresis assisted drug delivery system refers to a novel system for delivery of the drug in a non-invasive and effective manner across the skin or biological membranes by electrical assistance. Drug substances exhibiting low trans-corneal (ocular) permeability can be effectively delivered in a safe, fast, and painless manner by the employment of electric current of low intensity, which enhanc...

P. K. Soni * and T. R. Saini

Department of Pharmacy, Shri G.S. Institute of Technology and Science, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2547-56

2547-2556

657

255

6.

AN OLD ADAGE MANAGEMENT PERSPECTIVE FOR DANDRUFF

Dandruff is a well-known and global consumer problem, characterized by flaking and scaling of the scalp, with itching and irritation. Although it is not a life-threatening disease, but it is directly related to individual self-esteem, confidence, and beauty. Approximately half of the population is suffering from dandruff and expending around billions of dollars, including hospital services and cou...

Y. Ahmed, S. S. Jamil, A. Hashimi, M. B. Siraj and U. Jahangir *

Department of Amraz-e JildwaTazeeniyat (Skin), Hayat Unani Medical College and Research Center, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2557-65

2557-2565

264

116

7.

NANOPHYTOSOMES AN IMPERATIVE TECHNOLOGY FOR ENHANCING THE BIOAVAILABILITY OF BIOACTIVE CONSTITUENTS

Herbal medicine has been widely accepted as a promising approach for the treatment of various diseases with lower cost and minimized toxicity. Bioactive constituents isolated from the herbal source are equipped with synthetic drugs. The potency of any herbal medication is contingent on the delivery of the effectual level of the therapeutically active constituent. The integration of a novel drug de...

D. Lavanya * and A. S. Devi

Department of Pharmaceutical Chemistry Seven Hills College of Pharmacy Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2566-74

2566-2574

527

136

8.

RECENT FRONTIERS IN SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

Oral route has always been the preferred route of drug administration in many diseases. This route is limited to those drugs molecules that are permeable across the gastric mucosa and are sparingly soluble. Solubility is an important parameter to achieve the desired concentration of drug in systemic circulation for therapeutic response. As a consequence of modern drug discovery techniques, there h...

D. H. Shah * and M. M. Patel

Department of Pharmaceutics, Sal Institute of Pharmacy, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2575-91

2575-2591

339

366

9.

PROSTATE CANCER: RISK FACTORS, SCREENING, DIAGNOSIS AND TREATMENT

Prostate cancer is one of the most important cancer in men. In most cases, prostate cancer confirmed by histological and transrectal biopsy for the examination of prostatic tissue. Metastatic prostate cancer is second leading cause of death from cancer. Androgen deprivation therapy is common treatment in men with prostate cancer that may cause fatigue, increased body fatness, and loss of lean body...

P. B. Mairal * and Y. B. Mali

Department of Pharmaceutical Chemistry, Matoshri College of Pharmacy, Ekalehare, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2592-03

2592-2603

259

369

10.

A REVIEW ON TRANSLATIONAL PERSPECTIVE AND EFFICACY OF DIFFERENT ENGINEERED THERAPEUTIC ANTIBODIES

From bench to bedside, clinical research had always played as a convenient tool in the field of cancer biology to inquire about the effectiveness of different anticancer drugs on different human-derived cancer cell lines. According to the American Cancer Society, nearly 4000 new cases and 1600 deaths predicted in 2019 in the United States. Besides, to these alarming statistics, rising cost and hea...

C. Roy and T. Chakraborty *

Department of Biotechnology, Guru Nanak Institute of Pharmaceutical Science and Technology, Panihati, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2604-16

2604-2616

231

110

11.

PRODUCTION AND PURIFICATION STRATEGIES FOR LACCASE

Laccase belongs to polyphenol oxidases, which is a very wide family of copper-containing atoms in the center, which serves as the catalytic site. It is biochemically a glycoprotein with molecular mass being between 50kda to 130kda and 30% carbohydrate content, in addition to this it has three types of copper atoms. It is one of the most important enzymes due to its role in the food industry. It ac...

N. Dhull, M. Michael, P. Simran, V. R. Gokak and E. Venkatanagaraju *

Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2617-25

2617-2625

356

136

12.

EUDRAGIT: A VERSATILE AND ROBUST PLATFORM

In many aspects, polymeric materials have a pre-eminent position among excipients as they form the backbone of modern pharmaceutical formulations and drug delivery technologies in particular. A polymer is a natural, semi-synthetic or synthetic substance that is combined with a drug or other active pharmaceutical ingredient or excipient to release the drug in a pre-programmed manner. The drug deliv...

S. Bhilegaonkar and A. Parvatkar *

Department of Pharmaceutics, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi Ponda, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2626-35

2626-2635

441

107

13.

NANOEMULSION: A PROMISING AND NOVEL NANOTHERAPEUTIC VEHICLE FOR TRANSDERMAL DRUG DELIVERY

Transdermal delivery of therapeutics has been identified by scientific researchers as an alternative choice of drug administration, owing to its unique and tremendous benefit over conventional and oral administrations, but its exploration has been limited because of the “skin barricade” as its major challenge. A special formulation that is capable of meeting up and overcoming its associated ch...

O. B. Oyelaja, E. O. Dare, D. P. Katare * and F. O. Oladoyinbo

Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2636-48

2636-2648

257

132

14.

MEDICINAL SIGNIFICANCE OF BENZIMIDAZOLE ANALOGUES: A REVIEW

Benzimidazoles are well known biologically active N-containing heterocycles, widely used as drugs such as antifungal, antibacterial, antiparasitic, and antihelmintic. In addition, N1 and C2-substituted benzimidazoles and their derivatives have been found to be potent biologically active compounds as well. Further, N1-substituted benzimidazoles have exhibited anti-microbial, antihelmintic activitie...

S. B. Patil

Department of Chemistry, Ramaiah Institute of Technology, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2649-54

2649-2654

266

122

Research Articles

 
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15.

ANTIPSORIATIC EFFECTS OF CLOBETASOL LOADED SOLID LIPID NANOPARTICLES ON IMIQUIMOD INDUCED PSORIASIS IN BALB/C MICE

The aim of the current investigation was to prepare and investigate the potential of Clobetasol (CP) loaded solid lipid nanoparticles based gel (SLN-gel) for the dermal delivery and to evaluate its anti-psoriatic efficacy by comparing with conventional ointment formulation. This study will provide an insight into the use of nanocarriers, esp. SLNs loaded with CP for the effective treatment of psor...

K. R. Reddy *, P. Sucharitha, S. V. Satyanarayana and V. J. Reddy

Department of Pharmaceutics, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2655-70

2655-2670

798

282

16.

PRELIMINARY PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS FOR IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM ABUTILON FRUTICOSUM GUILL AND PERR. A RARE AND ENDEMIC PLANT OF INDIAN THAR DESERT

Present work was aimed to determine, identify, and characterize the bioactive chemical compounds from methanolic leaves extract of Abutilon fruticosum by GC-MS analysis. Fresh disease-free leaves were collected shade dried and powdered for extraction with HPLC grade methanol. Preliminary phytochemical screening of methanolic leaves extract was performed using standard methods to determine the pres...

I. Bano and G. S. Deora *

Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2671-79

2671-2679

590

281

17.

IN-VIVO EFFECT OF WITHACOAGULIN AND COAGULIN C ISOLATED FROM WITHANIA COAGULANS DUNAL FRUITS ON BLOOD PRESSURE OF ALBINO RATS

The present study was designed to evaluate the in vivo effect of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits on blood pressure of albino rats. DOCA (10 mg/kg; i.p.) along with diet high in sodium chloride salt was used to induce hypertension in rats. Comparative effects of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits were observed. Femal...

Q. Hoda * and K. P. Modi

Department of Pharmacy, Ram-Eesh Institute of Vocational and Technical Education, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2680-84

2680-2684

520

235

18.

STRUCTURAL ELUCIDATION OF CHITOSAN BASED HETEROCYCLIC COMPOUNDS OF ANTI-MICROBIAL AND ANTI-CANCER ACTIVITY

Schiff bases from chitosan and 5-nitro salicylaldehyde-aniline complexes represented the important structural subject in excess of biologically active molecules, including synthetic. The introduction of 5-nitro salicylaldehyde at C-2 nitrogen position and aniline at C-6 oxygen position of chitosan. The structure-activity relationship (SAR) of the double Schiff based chitosan, synthesized from the ...

R. I. Malarselvi *, A. Deepika, C. R. Raja and R. Priscilla

Department of Physics, D. G. Government Arts College, Mayiladuthurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2685-91

2685-2691

582

220

19.

FORMULATION AND EVALUATION OF FEBUXOSTAT FAST DISSOLVING TABLETS USING STERCULIA FOETIDA SEED STARCH AS EXCIPIENT BY LYOPHILIZATION TECHNIQUE

The present work is focused on the formulation of Febuxostat fast dissolving tablets by lyophilization technique using natural starch extracted from Sterculia foetida seeds. Starches were extracted using the alkali method, i.e., sodium hydroxide at 0.1%, 0.25%, and 0.5% concentrations and water from Sterculia foetida seed powder. These starches were evaluated for phytochemical and physicochemical ...

D. Sandeep *, S. Vidyadhara and J. Chirudeep

Department of Pharmaceutics and Physiology and Pharmacology, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2692-04

2692-2704

594

261

20.

DEVELOPMENT OF STABILITY INDICATING HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF TENELIGLIPTIN AND METFORMIN: APPLICATION TO ALKALINE DEGRADATION KINETIC STUDY

Stability indicating the HPTLC method was developed for simultaneous estimation of teneligliptin and metformin by using aluminum plates precoated with silica gel 60 F224 (Merck) and mobile phase toluene: methanol: GAA: TEA (5:4:0.5:0.5) with scanning wavelength of 257 nm. The developed method was validated for linearity, stability, accuracy, precision, robustness, LOD and LOQ as per ICH guidelines...

R. S. Bhimanwar *, L. Kothapalli and A. Malani

Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(1).2705-17

2705-2717

212

106

21.

DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF NANOCRYSTALS OF NITROFURANTOIN

Nitrofurantoin is a broad-spectrum bactericidal antibiotic that affects both gram-negative and gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein, and cell wall synthesis. Nanocrystals of NFT were prepared by a cold high-pressure homogenization technique. To improve the dissolution rate, the drug was formulated in...

N. Goswami * and R. P. Patel

Department of Pharmaceutics and Pharmaceutical Technology, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2718-26

2718-2726

285

104

22.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF INOTUZUMAB OZOGAMICIN IN BULK DRUG AND INJECTION DOSAGE FORM

A simple, rapid, accurate, precise, and reproducible stability indicating RP-HPLC method for the estimation of Inotuzumab Ozogamicin in bulk and injection dosage form was developed and validated as per ICH guidelines. The separation was done using BDS C18 150 × 4.6 mm, 5 µ column. The mobile phase (Water and Acetonitrile 55:45% v/v) was pumped at 1.0 ml/min, and effluent was detected at 240 nm u...

T. Alluri * and E. P. Latha

Department of Pharmaceutical Analysis, CMR College of Pharmacy, Kandlakoya, Medchal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2727-32

2727-2732

213

96

23.

ANTIOXIDANT, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF DIFFERENT FRACTIONS FROM METHANOLIC EXTRACT OF PSIDIUM GUAJAVA L. LEAVES

Psidium guajava Linn. the most popular and widely cultivated fruiting plant all over Bangladesh. The present study was aimed to investigate the antioxidant, analgesic and antimicrobial activities of n-hexane (HPG), chloroform (CLPG) and ethyl acetate fractions (ET APG) obtained from methanol extract of Psidium guajava (MPG) leaves. The in-vitro antioxidant activity of fractions HPG, CLPG and ET AP...

C. Sultana, N. K. Kundo, S. Islam, R. Ahmed, S. Afrin, N. Saqueeb and M. I. I. Wahed *

Department of Pharmacy, University of Rajshahi, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.11(6).2733-38

2733-2738

472

139

24.

FORMULATION AND EVALUATION OF NOVEL SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM OF SUMATRIPTAN SUCCINATE

In migraine disease which is an autoimmune disorder, 5-HT1 receptor agonist like Sumatriptan succinate (STS) is widely used. Its bioavailability is 15-17% due to extensive presystemic metabolism. The objective of this work was to prepare Sumatriptan succinate (STS) in a self nanoemulsifying drug delivery system (SNEDDS) and then convert it into solid-SNEDDS (S-SNEDDS) via extrusion/spheronization ...

P. R. Patel *, K. D. Patel and A. Mahajan

Department of Pharmaceutics, Babaria Institute of Pharmacy, BITS Edu Campus, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2739-51

2739-2751

249

109

25.

PREPARATION AND CHARACTERIZATION OF FLOATING ALGINATE BEADS OF LAFUTIDINE AS A GASTRORETENTIVE DOSAGE FORM

Background: Lafutidine floating beads as a gastro-retentive dosage form antagonisms of histamine H2 receptor. It is used as anti-ulcerative agent. It is effective against the oesophageal lesions induced by acid reflux through inhibition of acid secretions. Objectives: The objective of the present work was to formulate and evaluate the floating beads of Lafutidine as a model drug. The objective of ...

Deepti, K. Kumar, G. Kaur * and D. Teotia

Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2752-60

2752-2760

208

105

26.

DESIGN AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF HERBAL DRUG COMPOUND

A glycyrrhetinic acid isolated from herbal plant Glycyrrhiza glabra (family Fabaceae), commonly known as licorice is used to formulate microemulsion as a self-emulsifying drug delivery system for oral administration using almond oil as the oil phase. Pseudoternary phase diagrams were constructed to determine the microemulsion existence region using surfactant (Tween 80) and co-surfactant (propylen...

N. Chivate *, A. Chivate, K. Wadkar and R. Shah

Department of Pharmaceutics, KCT’S Krishna College of Pharmacy, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2761-66

2761-2766

235

102

27.

EVALUATION OF AMELIORATIVE EFFECT OF SYZYGIUM CUMINI LEAVES ON ULCERATIVE COLITIS

Ulcerative colitis is a subtype of Inflammatory Bowel Disease. The leaves of Syzygium cumini belonging to the family Myrtaceae were selected to evaluate its efficacy in ameliorating the acetic acid-induced Ulcerative colitis. Male albino Wistar rats were randomly divided into five groups. Group 1 was given the vehicle tween 80, group II received 2 ml of 4% acetic acid solution on 8th day intrarect...

J. Deepa *, B. Prasanth, Joy L. Mary and B. Sini

Nirmala College of Pharmacy, Muvattupuzha, Eranakulam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2767-75

2767-2775

223

96

28.

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL N-(BENZOXAZOL-2-YL)-2-(2-OXOINDOLIN-3-YLIDINE) HYDRAZINE CARBOTHIOAMIDES

In view of the biological prominence of the benzoxazole derivatives as well as, isatin derivatives, it was planned to synthesize some novel N-(Benzoxazol-2-yl)-2-(2-oxoindolin-3-ylidine) hydrazine carbothioamides (VI) as such reports were not available in the literature and were screened for antibacterial, antifungal and anti-mycobacterial activity. Fourteen new compounds were synthesized by conde...

T. K. Kumar * and R. Sreenivasulu

Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2776-85

2776-2785

214

111

29.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IVABRADINE AND METOPROLOL IN TABLET DOSAGE FORM

The objective of the method is to develop a rapid, simple, accurate, precise RP-HPLC method for the simultaneous estimation of Ivabradine and Metoprolol in tablet dosage form. The analytes were run through BDS C18 150 × 46 mm, 5µm column, and detected at a wavelength of 260 nm using PDA 996 (photodiode array) detector. Mobile phase containing buffer 0.01N disodium hydrogen phosphate (3.5±1 pH) ...

S. Rajakumari, G. Rajitha * and A. G. Susmita

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2786-92

2786-2792

254

104

30.

FORMULATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF LORNOXICAM

The aim of the present study was to develop a controlled release formulation of Lornoxicam to maintain constant therapeutic levels of the drug for over 12 h. Guar gum, xantham gum, and carbopol 934 were employed as polymers. All the formulations were passed various physicochemical evaluation parameters, and they were found to be within limits. From the dissolution studies, it was evident that the ...

P. S. Kumar * and A. Sravani

Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2793-00

2793-2800

215

100

31.

PHARMACOKINETIC DRUG INTERACTIONS BETWEEN HMG-COA REDUCTASE INHIBITORS PITAVASTATIN WITH CONCOMITANTLY USED TICAGRELOR

In the present research, the pharmacokinetic Drug-drug interactions between HMG-COA reductase inhibitors Pitavastatin with concomitantly used Ticagrelor have been studied. Pitavastatin is a member of the blood cholesterol lowering medication class of statins while Ticagrelor is a platelet aggregation inhibitor. Combination therapy with statins and other cardiovascular medications is recommended fo...

M. A. H. Siddiqui and S. Roshan *

Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2801-06

2801-2806

229

101

32.

CLONAL MICROPROPAGATION OF THREATENED MORINGA CONCANENSIS NIMMO (MORINGACEAE): SUSTAINABLE ALTERNATIVE

Moringa is one of the medicinally important genera and Moringa concanensis Nimmo is a threatened species of it. Clonal micropropagation has been used to produce true to type multiple copies and help to conserve a number of plants. A comprehensive micro-propagation protocol has been developed in the present study. It was found that Murashige and Skoog (1962) (MS) basal elements enriched with 0.05 m...

Y. Master * and V. Somani

Department of Bioscience, Veer Narmad South Gujarat University, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2807-13

2807-2813

215

111

33.

REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SEPARATION AND ESTIMATION OF IMPURITIES PRESENT IN PHARMACEUTICAL FORMULATION OF CANAGLIFOZIN

Canagliflozin is sodium-glucose co-transporter-2 inhibitors work by inhibiting SGLT2 to prevent reabsorption of glucose and facilitate its excretion in urine. Impurities in pharmaceuticals which are unwanted chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during stability testing, or develop during formulation or upon aging of both API and formulation. The prese...

N. Patel * and S. Patel

Department of Quality Assurance, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidhyanagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2814-22

2814-2822

205

86

34.

STUDY ON QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES (IBD): IMPACT OF SOCIODEMOGRAPHIC FACTORS

Introduction: an Inflammatory bowel disease is a group of chronic intestinal diseases characterized by inflammation of the bowel, the large or small intestine. The common types of inflammatory bowel disease (IBD) are ulcerative colitis UC and Cohn’s disease CD. Among the Asian countries, India is subjected to have one of the highest disease burdens of IBD across the globe. The number of IBD case...

G. S. Prabha *, N. Srinivasan, S. Aravindh and K. T. M. Kumar

Department of Pharmacy Practice, KMCH College of Pharmacy [Affiliated to the Tamil Nadu Dr. M. G. R. Medical University] Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2823-27

2823-2827

223

99

35.

RELATIVE STRUCTURAL ANALYSIS OF LytTR DOMAIN OF AgrA PROTEIN INVOLVED IN BACTERIAL QUORUM SENSING

Resistance to antimicrobials by pathogenic bacteria is a global menace. An attractive pathway to resolve this problem of resistance may be achieved by targeting the bacterial quorum sensing (QS) process. Fighting bacterial infections by interfering with their command language and disrupting virulence expression could serve as a viable alternative. One of the current strategies is to attenuate viru...

H. K. Basak, A. Chatterjee and A. Pal *

Microbiology & Computational Biology Laboratory, Department of Botany, Raiganj University, Raiganj, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2828-39

2828-2839

217

100

36.

IN-VITRO EVALUATION OF ANTIOXIDANT ACTIVITIES OF OLDENLANDIA CORYMBOSA L. (SYN. HEDYOTIS CORYMBOSA) FRACTIONATED EXTRACTS IN VARIOUS SOLVENTS

Antioxidants are the substance having the potential to quench free radicals and significantly delay or inhibit oxidation of the substrate, thus protect biological systems against potentially harmful effects of free radicals; in low concentrations. The present study was aimed to evaluate the in-vitro antioxidant activity of Oldenlandia corymbosa L., a locally available medicinal plant of Assam, use...

G. K. Das and R. Bharali *

Department of Biotechnology, Gauhati University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2840-50

2840-2850

230

118

37.

PHARMACEUTICAL STUDY OF STEROIDAL COMPOUNDS AND ESSENTIAL OIL COMPONENTS OF SENECIO VULGARIS LINN. GROWN IN IRAQ

Objective: Senecio vulgaris Linn. generally known as common groundsel, known in Iraq as Sheikh Al-Rabeeor Al-Kurresa, which is widely distributed in the south and middle parts of Iraq. There was no systemic study in the literature regarding the phytoconstituents that are present in Iraqi’s Senecio vulgaris Linn. Thus, the present study was aimed to examine the presence of some biologically impor...

M. Y. Shareef * and H. K. Hamid

Ministry of Higher Education and Scientific Research, National University of Science and Technology, Thi Qar, Nasiriya, Iraq.

DOI: 10.13040/IJPSR.0975-8232.11(1).2851-59

2851-2859

262

94

38.

ESTIMATION OF PHYTOCHEMICAL CHARACTERISTICS AND ANTIOXIDANT PROPERTY OF SECONDARY METABOLITES OF A MEMORY ENHANCING MEDICINAL HERB BACCOPA MONNIERI OF EAST KOLKATA WETLAND

Herbal medicine nowadays offers several options to modify the progress and symptoms of medicines. There has been a new trend in the preparation and marketing of drugs based on medicinal plants and their scientific and commercial significance. These plant-derived products are carefully standardized and their efficacy and safety for a specific application have been demonstrated. The objective of thi...

S. Dutta and S. Chakraborty *

Department of Biotechnology, Gurunanak Institute of Pharmaceutical Science and Technology, Panihati, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2860-67

2860-2867

287

99

39.

PREFORMULATION STUDY FOR CANDESARTAN CILEXETIL BUCCAL (EFFERVESCENT) TABLET

Candesartan cilexetil is a novel, potent, and highly selective non-peptide angiotensin II type 1 receptor blocker. It is a hydrophobic drug that belongs to the BCS Class II drug. For enhancement, the bioavailability and quick systemic action of Candesartan cilexetil a novel formulation of buccal (effervescent) tablet, was designed.  Preformulation is an important step in the rational formulation ...

K. Pansuriya *, P. Shelat and H. Patel

K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2868-74

2868-2874

245

117

40.

ISOLATION AND CHARACTERIZATION OF PHYTOSTEROLS FROM DIEFFENBACHIA AMOENA LEAF EXTRACT

Dieffenbachia amoena is a house plant and known dumb cane. The study was performed based on isolation and structure elucidation of phytosterols from the extract of this plant. The CH3OH crude extract was loaded over the silica gel (60-120 mesh) column, using the stepwise gradient C6H6, CH3OAc, CH3OH. The fractions were further purified by preparative TLC (GF254) to yield compound (1). Compound (1)...

M. Rehan, Shafiullah * and O. Singh

Department of Chemistry, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2875-81

2875-2881

242

121

41.

THERAPEUTIC AND PREVENTIVE ROLE OF FUNCTIONAL FOODS IN PROCESS OF NEURODEGENERATION

Diet and dietary habits of an individual are considered to be an essential factor based on biologically active compounds extracted or modified from either known or unknown natural sources, contributing to completing the dietary and nutritional needs beyond the traditional supplements. Moreover, the latest research information about their supportive and therapeutic utility suggests that they play a...

H. Kaur, S. Agarwal, M. Agarwal, V. Agarwal and M. Singh *

Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2882-91

2882-2891

233

106

42.

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROFILE OF EPLERENONE BY LIQUISOLID COMPACTS USING NOVEL EXCIPIENTS

Eplerenone is a poorly soluble drug that belongs to class II biopharmaceutical classification system. It is a selective aldosterone receptor antagonist, which binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreases the sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure and used in congestive heart failure...

G. N. Naik * and R. S. Sunder

Jyothishmathi Institute of Pharmaceutical Sciences, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2892-98

2892-2898

247

105

43.

SOLID DOSAGE FORM DEVELOPMENT OF DABIGATRAN ETEXILATE MESYLATE WITH INCREASED SOLUBILITY AND DISSOLUTION USING COCRYSTALLIZATION

Dabigatran Etexilate Mesylate (DEM), an anticoagulant used to treat and prevent blood clots and to inhibit the occurrence of stroke in people with cardiac arrhythmia. The purpose of this study was to obtain DEM co-crystals by screening eight different conformers and prepare the co-crystals by evaporation technique. Molecular docking was used to identify suitable coformer. Tartaric acid DEM co-crys...

A. R. Gawade and S. P. Boldhane *

Development Micro Labs Limited Micro Advanced Research Centre (Marc), Bangalore, Karnataka India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2899-05

2899-2905

277

116

44.

FORMULATION AND EVALUATION OF A pH DEPENDENT MULTI-PARTICULATE COLON TARGETED DRUG DELIVERY SYSTEM USING POWDER LAYERING TECHNOLOGY OF KETOPROFEN

Multiparticulates consist of discrete, small, multiple unit systems of active pharmaceutical ingredients exhibiting the desired drug release pattern. The present work is concerned with the formulation and evaluation of a pH-dependent multiparticulate colon targeted drug delivery system of ketoprofen, a well established anti-inflammatory drug used in the management of inflammatory bowel disease. Th...

D. P. Ghosh, A. Mittal *, A. Gaur and J. Sahoo

KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2906-13

2906-2913

230

85

45.

TRENDS IN ANTIEPILEPTIC DRUGS PRESCRIPTION PATTERN AMONG PATIENTS VISITING A TERTIARY CARE CENTER

The objectives were to observe the drug pattern of epileptic patients with their seizure type, to analyze the type of therapy received by the patients, to observe if epileptic patients are receiving an appropriate dose, to identify the side effects in epileptic patients associated with drug treatment and to observe the cost of conventional and newer antiepileptic drugs (AED’s). This was a cross-...

K. Gayathri *, R. M. Shireen, V. Lalasa, A. Suresh, G. Andhuvan and R. S. Iyer

Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2914-19

2914-2919

252

97

46.

DESIGN, SYNTHESIS AND EVALUATION OF ANTI TUBERCULAR ACTIVITY OF NOVEL TRIAZOLE DERIVATIVES

Substituted triazoles have received considerable attention during the last two decades as they are endowed with a variety of biological activities and have a wide range of therapeutic properties. The present work is concerned with the synthesis of fused 1, 2, 4-triazole derivatives with the objective of discovering novel and potent anti-tubercular agents that might be devoid of harmful side effect...

N. R. Babu *, U. Kulandaivelu, G. S. N. K. Rao, R. R. Alavala, Y. Padmavathi and B. M. Reddy

Department of Pharmaceutical Chemistry, K. L. College of Pharmacy, K. L. Deemed to be University, Vaddeswaram, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2920-25

2920-2925

259

107

47.

EVALUATION OF PHYTOCHEMICAL COMPOSITION AND ANTI-OXIDANT POTENTIAL OF ANDROGRAPHIS SERPYLLIFOLIA (VAHL) WIGHT: AN ENDEMIC ANTI-OPHIDIC PLANT

In folk medicine, especially in developing countries, several plant species are employed for the treatment of snakebites that lack prompt access to serum therapy. Andrographis serpyllifolia (Vahl), belonging to Acanthaceae, has been recorded in ethnobotanical archives as a plant possessing potent anti-ophidic activity for snake bites. The present study emphasis to investigate the phytochemical pro...

V. S. Hansiya and N. Geetha *

Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2926-36

2926-2936

240

104

48.

FORMULATION AND EVALUATION OF FIXED DOSE COMBINATION OF ATORVASTATIN CALCIUM AND AMLODIPINE BESYLATE IMMEDIATE RELEASE FILM-COATED TABLETS

The present research work was envisaged to develop immediate release film-coated tablets of a fixed-dose combination of Atorvastatin calcium and Amlodipine besylate used to treat the hyperlipidemia, angina pectoris, atherosclerosis, hypertension and symptoms of cardiac risk. Additionally, fixed-dose combination therapy of both drugs tends to provide a synergetic effect and reduce the pill burden. ...

S. Pahuja, N. Sharma and P. Sarup *

Swami Vivekanand College of Pharmacy, Banur, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2937-47

2937-2947

255

111

49.

CULTURED MYCELIA OF PADDY STRAW MUSHROOM, VOLVARIELLA VOLVACEA (BULL: FR) SINGER PROTECTS WISTAR RATS FORM ACETAMINOPHEN-INDUCED HEPATOTOXICITY

Even though numerous herbal preparations have been recommended in alternative systems of medicine against hepatic disorders, many of them cause severe toxicity upon prolonged use. Volvariella volvacea (Bull.: Fr.) Singer is a highly nutritious mushroom that can be incorporated into the regular diet without the fear of side effects. The protective effect of the aqueous ethanol extract of V. volvace...

J. Mathew, T. P. Smina, N. P. Sudheesh and K. K. Janardhanan *

Amala Cancer Research Centre, Thrissur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2948-54

2948-2954

200

97

50.

A PROSPECTIVE STUDY ON EFFICACY OF TRIMETAZIDINE AND ISOSORBIDE DINITRATE IN CORONARY ARTERY DISEASE

Background: The aim of this prospective study was to observe the efficacy of Trimetazidine (TMZ) and Isosorbide dinitrate (ISDN) in Coronary Artery Disease (CAD). Through inhibition of cardiac fatty acid oxidation, trimetazidine strengthens the treatment of CAD, by relieving aggravation; enhancing heart function, essential to prevent heart failure and other serious complications. Methods: 120 pati...

S. P. Bharathi and S. S. Kumar *

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2955-61

2955-2961

273

106

51.

DEVELOPMENT OF ANALYTICAL METHOD AND VALIDATION OF NADOLOLIN PURE AND PHARMACEUTICAL FORMULATIONS USING UV-SPECTROPHOTOMETRY AND SPECTROFLUORIMETRY

The development of analytical methods is in need for the estimation of drugs in pure and different pharmaceutical formulations. A simple, sensitive, rapid, accurate, precise and economic spectrophotometric and spectro-fluorimetric method was developed and validated for Nadolol in pure and pharmaceutical formulations. The proposed method was validated according to the International Conference on Ha...

V. Veeramanikandan, R. Arun and A. Antonsmith *

Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2962-68

2962-2968

194

93

52.

FORMULATION AND EVALUATION OF FEXOFENADINE HYDROCHLORIDE LOADED CHITOSAN NANOPARTICLES FOR TREATMENT OF SKIN ALLERGY

An attempt was made to formulate and evaluate Fexofenadine HCl loaded chitosan nanoparticles using biodegradable polymers such as chitosan and sodium tripolyphosphate as a crosslinker in different ratio and proportions. In this formulation, Fexofenadine HCl was selected because of wide range of its use in treatment of skin allergy in the form of coated tablet and pediatric suspension. Different fo...

M. Gharibshah *, M. Tajmal and R. Karki

Department of Industrial Pharmacy, Acharya and BM Reddy College of Pharmacy, Soladevanahalli, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2969-75

2969-2975

323

115

53.

FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF VERAPAMIL HYDROCHLORIDE

Verapamil hydrochloride is a water-soluble drug, so it is suitable to develop controlled porosity osmotic pump.  As Verapamil HCl is a short-acting drug, so developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need for laser drilling, and economical, all of which made the proced...

M. A. Shivnikar * and P. N. Bhong

Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2976-83

2976-2983

235

95

54.

COMPARATIVE GROWTH ANALYSIS OF CYANOBACTERIA FROM DIVERSE HABITATS WITH REFERENCE TO PIGMENTS

Cyanobacteria are a gram-negative group of microorganisms with unique features and found in diverse conditions of the environment. These tiny bio-factories are rich in pigment molecules like chlorophylls, carotenoids and phycobiliproteins. Studies on physiological and biochemical characteristics of different cyanobacterial strains will not only help to determine their biotechnological potential bu...

R. Kaur, A. Rahman, M. Mishra, S. K. Singh, S. Sundaram * and S. Alok

Centre of Biotechnology, Nehru Science Centre, Centre of Biotechnology, University of Allahabad, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2984-89

2984-2989

225

97

55.

ASSESSMENT OF THE AWARENESS LEVELS TOWARDS VITAMIN D CHECK, MEDICATION AND RELATED DISORDERS

Background: Vitamin D deficiency and its associated disorders are prevalent in Saudi Arabia. This study aimed to assess the awareness levels towards vitamin D, check, medication, and related disorders. Methodology: In this cross-sectional study, a total of 500 Saudi volunteers living in the city of Hail (A region in Northern Saudi Arabia) and surrounding towns were included during the period from ...

K. F. Alshammari *, A. O. A. Hassan, A. A. Alkhateeb, A. D. Altamimi, A. K. AlShammari, M. S. Alharbi, S. M. Almarshedy and H. G. Ahmed

Department of Internal Medicine, College of Medicine, University of Hail, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(6).2990-95

2990-2995

231

95

56.

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF FAMOTIDINE WITH HYDROPHILIC POLYMERS BY SOLID DISPERSION TECHNIQUE

Objective: In the present study to enhance solubility and in vitro dissolution of poorly aqueous soluble drug Famotidine by preparing solid dispersions using the Kneading method. Methods: Solid dispersions of the drug were prepared by the kneading method using Kollidon and Povidone K30 (as a carrier). Eight different drugs: Carrier ratios were prepared by Factorial design taking three factors, i.e...

V. T. Wagh *, R. M. Gilhotra and R. D. Wagh

Department of Internal Medicine, College of Medicine, University of Hail, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(6).2996-02

2996-3002

329

141

57.

SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF PERACETIC ACID AND THE COEXISTENT HYDROGEN PEROXIDE USING CARBOSITALL ROTATION ELECTRODE

The aim of the present work is to determine the feasibility of peracetic acid (PAA) and the coexistent hydrogen peroxide (HP) simultaneous quantitative determination in disinfectant solution by voltammetry using carbositall rotation electrode (CE) as indicating electrode. It has been experimentally proved that the optimum pH for analysis is approximately 3.6. The linear relationship has been obse...

O. O. Mozgova *, M. Y. Blazheyevskiy, S. P. Karpova and A. D. Gordienko

Department of Physical and Colloid Chemistry, National University of Pharmacy, Kharkiv, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.11(6).3003-08

3003-3008

225

99

58.

SYNTHESIS, CHARACTERISATION OF IMPURITY PRESENT IN THE MANUFACTURE OF LOPRAZOLAM AND STUDY OF IMPURITY PROFILE BY HPLC

The reaction of 5- (2- chlorophenyl)- 7- nitro- 3H- 1, 4-benzodiazepin-2-thione (I) with glycine (A) by means of Na2CO3 in refluxing ethanol in water gives 2-carboxymethylamino-7-nitro-5-(2-chlorophenyl)-3H-1, 4-benzodiazepine(II), which is cyclized by means of dicyclohexylcarbodiimide in methylene chloride to afford 8-nitro-(2-chlorophenyl)-1,2-dihydro-1H,4H-imidazo[1, 2-a] [1, 4]benzodiazepin-1-...

M. Joseph *, S. Alexander and A. K. Das

Department of Pharmaceutical Chemistry, Nehru College of Pharmacy, Pambadi, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).3009-20

3009-3020

263

163

59.

DEVELOPMENT OF FLOATING DRUG DELIVERY SYSTEM FOR LORATADINE: IN-VITRO AND IN-VIVO EVALUATION

The reason for this exploration was to develop gastro-retentive drug delivery systems (GRDDS) of loratadine (LTD) to lengthen the gastric residence time (GRT) by using different polymers like hydroxypropyl methyl celluloses (i.e., HPMC K4 M, HPMC K15 M, HPMCK 100 M), xanthan gum and other excipients such as microcrystalline cellulose (MCC), sodium bicarbonate (NaHCO3), magnesium stearate. All LTD ...

S. N. Sapavatu and R. K. Jadi *

Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).3021-32

3021-3032

221

125

60.

NEUROPROTECTIVE EFFECT OF LEUCASASPERA IN STREPTOZOTOCIN INDUCED ALZHEIMER RAT MODEL

The present investigation deals with the assessment of neuroprotective effect Leucasa spera in streptozotocin (STZ) induced Alzheimer’s disease (AD) in rats. AD was induced by administering STZ (3 mg/kg, ICV) on day one and 3rd day after surgery. Surgery was performed on anesthetized rats with the help of the stereotaxic apparatus. STZ induced AD rats were treated with ethanolic extract of Leuca...

R. Vadivelan *, U. Shrisha and H. N. Ahamed

Department of Pharmacology, J. S. S. College of Pharmacy, (J. S. S. Academy of Higher Education & Research), Ootacamund, Nilgiris, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3033-39

3033-3039

175

80

61.

PRELIMINARY PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF METHANOLIC LEAF EXTRACT OF TEPHROSIA FALCIFORMIS RAMASWAMI FROM INDIAN THAR DESERT

Present study was conducted to identify and characterize the phytoconstituents of methanolic extract of leaves of Tephrosia falciformis (Pers.) Ramaswami of family Fabaceae. The methanolic extract of leaves was subjected to qualitative screening for primary and secondary metabolites as per standard methods; further GC-MS analysis was carried out for the identification of secondary metabolites. The...

Vandana and G. S. Deora *

Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).3040-46

3040-3046

148

116