Volume 11 (2020) - Issue 11, November
Review Articles
TARGET BASED PHARMACOLOGICAL APPROACHES FOR DRUG DEVELOPMENT AGAINST NOVEL CORONA VIRUS (COVID-19)
The novel coronavirus (COVID-19) outbreak has covered almost 185 countries worldwide, causing infection to 32, 50,000 people and the death of approximately 2, 30,000 people to date. World Health Organisation (WHO) has declared it a pandemic that seems to be unstoppable as no vaccine or drug is available as of now to kill the virus. Several research labs are trying to develop a vaccine against the ...
2452
958
HYDROXYCHLOROQUINE (HCQ) AS AN EMERGING AND PROMISING DRUG CANDIDATE IN COVID-19 PANDEMIC – A SYSTEMATIC REVIEW
Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of...
1792
1189
MITOGENIC, ANTIOXIDATIVE AND ANTIMICROBIAL ACTIVITIES OF G-90 AND COELOMIC FLUID FROM EARTHWORM AS A THERAPEUTIC AGENT, A REVIEW
The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part. These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid. The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication. The antimicrobial a...
1914
986
A REVIEW OF SOME MEDICINAL PLANTS ON THEIR ANTIULCER AND ULCER HEALING POTENTIAL
The imbalance between aggressive (pepsin, Hydrochloric acid) and protective elements (bicarbonate and mucosa) in the inner lining of the stomach lead to the formation of peptic ulcers. The presence of Body fluids, mucosal hydrophobicity, fast epithelial cell recharging, and rich mucosal blood flow is involved in mucosal protection of the Stomach. Prostaglandins E2 and I2 are the predominant pros...
2466
1099
PLANT-BASED TRADITIONAL REMEDIES FOR SNAKEBITE IN INDIA: A RECENT UPDATE REVIEW
Medicinal plants are a potential source of therapeutic drugs and play a central role in the health care system throughout the world. Plants have been an integral part of the life of many indigenous communities. Snakebite is a neglected tropical disease. Snakebite remains a major health concern throughout the world, especially in India. The highest Morbidity and Mortality occurs in rural and tribal...
4637
1756
PEPTIC ULCEROGENESIS: ETIOLOGY, PATHOGENESIS AND VARIOUS CLINICAL ASPECTS
“Eat to live and don’t live to eat” this is a principle to be followed for a healthy and wealthy life. According to the therapeutic point of view, the patient who suffers from peptic ulcer diseases was shown to have a reduced secreted amount of HCl and pepsin. The management of gastric and duodenal ulcers can be followed by the decreased or neutralized level of gastric acid. Peptic ulcer inf...
1338
632
DIVERSE STRATEGIES TO BOOST UP SOLUBILITY OF POOR WATER SOLUBLE DRUGS – A REVIEW
As we understand that for achieving a supportive effect in the human body, the prescription should be bioavailable, and in this way, it depends upon the dissolvability of the drug. Starting late 40% of the meds are inadequate water dissolvable, which produces responses, for instance, gastric exacerbation, peptic ulceration, etc. An oral course of medication organization is the most favored defeat ...
1879
607
REVIEW ON MICROSPONGE LEADING MICROPOROUS PARTICULATE TECHNOLOGY WITH CONTROLLED RELEASE, IMPROVE STABILITY TO PROVIDE OPTIMUM SKIN DISORDERS MANAGEMENT ENVIRONMENT FOR THERAPEUTIC APPLICATION
Although serious systemic and cutaneous side effects need a novel delivery system that provides prolonged and controlled drug release, minimum systemic drug absorption with reduced side effects. Microsponge, a drug delivery system, possesses the versatility to load a wide range of active ingredients to facilitate the controlled release of active ingredients to reduce systemic exposure and to reduc...
1453
1240
HERBONANOCEUTICALS: A NEWER APPROACH FOR DELIVERING HERBAL DRUGS
“Nanotechnology” is a science which deals with the particles less than the size of 100 nm. Materials at the atomic and molecular scales are engineered and manufactured by this technology. The use of nanotechnology for “phytotherapy” or treatment of various diseases by herbal medicines/drugs, including herbal drug delivery, where current and emerging nanotechnologies could enable entirely n...
1275
1215
ORAL LIPID BASED DRUG DELIVERY SYSTEM: A REVIEW
In the recent progressive era of pharmaceutical technology, newly investigated most of the drugs come under BCS class II and IV having low solubility as well bioavailability. The drugs are not suitable candidate for the conventional oral delivery of drug. The reason is that the drugs are not able to dissolve in aqueous environment of GI (gastrointestinal) tract. Poor water solubility of drug is ch...
2221
1185
FORMULATION AND EVALUATION OF GASTRO-RETENTIVE FLOATING MICRO-SPHERES: A SYSTEMATIC REVIEW
Gastro-retentive drug delivery system is the novel controlled release system that overcomes the problem like the first-pass metabolism, narrow index of absorption, unstable in intestinal pH, low bioavailability. Different approaches to GRDDS are floating, mucoadhesive, swelling, high density, magnetic drug delivery system. The floating drug delivery system is the most promising approach. The dosag...
3169
1616
A REVIEW ON THE ROLE OF NATURAL REMEDIES IN PSORIASIS THERAPY
Psoriasis is a chronic inflammatory disease that affects about 1-2% population. It is caused by different factors, the most common cause being genetic predisposition. Other causes or factors that can trigger psoriasis include infection, physical trauma to the skin, stress and certain medication, for example, beta-blockers and antimalarials. People suffering from psoriasis are at a greater risk of ...
1179
633
A REVIEW ON THE ANTIBACTERIAL POTENTIAL OF INVASIVE WEEDS USED FOR THE TREATMENT OF CARBUNCLE IN PURULIA DISTRICT OF WEST BENGAL INDIA
Carbuncle is a serious skin disease that affects tribal communities very quickly. The disease is generally caused by Staphylococcus aureus, Escherichia coli, or Streptococcus pyogens. Due to increasing drug resistance in these bacterial strains, it has become very difficult to treat carbuncle with modern antibiotics. The information about tribal peoples using invasive weeds to treat carbuncle is e...
1136
709
AN OVERVIEW OF OVARIAN CYSTS
To study various types of the benign cyst, differential diagnosis, diagnosis for identification of cyst, suitable treatment options based on various types of cysts that are occurring in the ovaries. An ovarian cyst is a commonly occurring mass in reproductive-age women. Functional ovarian cysts are physiologic and usually dissolve spontaneously within a couple of menstrual cycles. A combination of...
4487
1968
THERAPEUTIC SIGNIFICANCE OF INDOLE SCAFFOLD IN MEDICINAL CHEMISTRY
Discovery of New Chemical Entities (NCEs) is the result of a series of high throughput screening process after the successful design and synthesis scheme. The indole nucleus is an important heterocyclic compound containing nitrogen, and it has been a source of vital therapeutic agents. It is noteworthy in recent advances of synthetic, medicinal chemistry; the last decade has been witnessed with a ...
2655
1630
Research Articles
IN-VITRO AND IN-VIVO SYNERGISM BETWEEN VALSPODAR (PSC833) AND ANTIBIOTICS AGAINST STAPHYLOCOCCUS AUREUS STRAINS
Here, we report the in-vitro and in-vivo effects of Valspodar (PSC833), a second-generation mammalian efflux pump inhibitor on the susceptibility of methicillin-resistant and methicillin-sensitive Staphylo-coccus aureus (MRSA and MSSA) towards two antibiotics, Oxacillin (OX) and Cefoxitin (FOX). Checkerboard microdilution assays revealed various degrees of strain-dependent synergy demonstrated in ...
1407
707
HELICOBACTER PYLORI INFECTION: A BIOINFORMATIC APPROACH
Helicobacter pylori causative agent of acid peptic disease is a microaerophilic, spiral-shaped, gram-negative bacteria found in the gastric epithelium that may also lead to complications such as chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, gastroduodenal ulcer and adenocarcinoma in stomach. Plantbioactives have always been potential therapeutics. Usage of modern bioinform...
1589
718
INCREASED PROPERTIES AND CITOCOMPATIBILITY OF ZINC OXIDE-MAGNESIUM CEMENT
Zinc oxide-magnesium has been used in dentistry with limitations especially related to its high acidity and low biocompatibility. The objective of this study was to develop cement based on nano-hydroxyapatite (nHA), chitosan as more biocompatibility agents to increase zinc oxide-magnesium cito-compatibility. The formulations prepared were: 1. Complete cement (HCP) with nHA, zinc oxide-magnesium, a...
2191
774
PROTECTIVE EFFECT OF NARINGIN AGAINST CEREBRAL INFARCTION INDUCED BY ISCHEMIC-REPERFUSION IN RATS
Background: Leukocytes play an important role in tissue apoptosis as scavengers and vital components of inflammation, which has been generated during ischemia-reperfusion injury. The present study aimed to investigate the cerebroprotective potential of naringin through anti-inflammatory mechanism. Methods: Cerebral infarction was induced through bi-lateral common carotid artery occlusion for 30 mi...
975
513
A STATISTICAL APPROACH TO DEVELOPMENT OF SUSTAINED RELEASE PRONIOSOMAL MICONAZOLE NITRATE GEL
Miconazole nitrate is a broad-spectrum antifungal agent, and it is used for the treatment of superficial fungal infections. It has low skin permeability. Therefore, the aim of this study was to prepare proniosomal 2% miconazole nitrate sustained release to a treat deep-seated fungal infections. The different batches of proniosomal 2% miconazole nitrate gel were prepared by the conservation phase s...
1394
760
SYNTHESIS OF NEW 2, 5, 6-SUBSTITUTED IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS
A series of 2-cyclopropylimidazo [2,1-b] [1,3,4] thiadiazole derivatives 5(a-i) have been synthesized by reacting 5-cyclopropyl-1,3,4-thiadiazol-2-amine (3) and an appropriate 2-bromo-1,2-(substituted aryl) ethanones 4(a-i). Structures of these compounds were recognized by IR, 1H NMR, 13C NMR spectroscopy and Mass spectrometry. Hypoxia-inducible factor (HIF) has been identified as an important can...
1099
781
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF NEBIVOLOL AND VALSARTAN
Better patient compliance can be achieved using a combination of two drugs compared to a single drug. The main objective of the present research work has been done to prepare fast dissolving tablets of Nebivolol HCl (NEB) and Valsartan (VAL) using super disintegrating agents. Solid dispersions of VAL were prepared with Mannitol to improve the solubility and release behavior in dissolution flui...
3928
1701
DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR IDENTIFICATION AND QUANTIFICATION OF URSOLIC ACID IN THE LEAVES OF ALSTONIA SCHOLARIS
Herbs have been used since antiquity for treatment and management of various disease conditions. Their ability to cure or prevent diseases is due to storehouses of various phytoconstituents like alkaloids, flavonoids, glycosides, terpenoids, steroids, tannins, phenols, etc. present in them. Pentacyclic triterpenoids have gained greater attention of researchers due to its wide array of pharmacologi...
1150
584
EVALUATION OF COGNITION ENHANCING ACTIVITY OF SESBANIA GRANDIFLORA (L.) FRUITS EXTRACT ON HIGH FAT DIET INDUCED DEMENTIA
The study was aimed to justify the traditional claim of fruits of Sesbania grandiflora (Leguminosae) as a medhya rasayana. Dementia was induced with chronic administration of a high fat diet for 90 days. Petroleum ether, benzene, chloroform, acetone, ethanol extracts of fruits of Sesbania grandiflora were evaluated for cognition-enhancing activity in high-fat diet-induced dementia in rats using an...
1189
606
BIOACTIVE COMPOUND ANALYSIS AND BIOACTIVITIES OF ENDOPHYTIC BACTERIA FROM CISSUS QUADRANGULARIS
Endophytic bacteria were isolated from the stem of Cissus quadrangularis on Nutrient agar medium. The bacterial isolates were cultured in Nutrient broth. Ethyl acetate extracts of endophytic bacteria were evaluated for the presence of bioactive compounds and total phenolic content. The phytochemical screening of extracellular ethyl acetate extracts showed the presence of phenols. The total phenol ...
1364
682
QUALITY BY DESIGN APPROACH TO OPTIMIZE OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM
The present investigation deals with the development of the controlled porosity osmotic pump (CPOP) tablet of Garcinia indica fruit rind extract used in the management of colon cancer by implementing the concept of Quality by Design (QbD). The quality target product profile (QTPP) and Critical Quality Attributes (CQA) of the Garcinia indica tablets were defined based on preliminary studies. The ef...
1297
697
CHEMICAL COMPOSITION OF ESSENTIAL OIL OF EQUISETUM DIFFUSUM: A NOBLE SOURCE OF PHYTOL
Plants as a source of medicine have been inherited and are an important component of the health care system in India. Equisetum diffusum D. Don (Equisetaceae) is one of the medicinally important plants, which is a native species to the Himalayan Mountains. It is popularly known as Himalayan horsetail. The present endeavor deals with the exploration of the chemical composition of Himalayan E. diffu...
1295
661
TOXICITY EVALUATION AND BEHAVIOURAL CHANGES OF LABEO ROHITA EXPOSED TO ETHION 50% EC
Modernization and intensification of agricultural production is generally accompanied by a rapid increase in the use of chemical fertilizers and pesticides. Ethion 50% EC is a broad-spectrum organophosphate insecticide used to control insects, mites, and nematodes by soil, foliar, and seed treatment applications, mainly on potatoes, sugar beet, rice, and maize, citrus. The aim of the present study...
1151
677
FORMULATION AND EVALUATION OF VERNONIA ELAEAGNIFOLIA PHYTO-FORMULATION FOR THE MANAGEMENT OF HYPERLIPIDAEMIA
The aim of the present investigation was to formulate and evaluate phytoformulation prepared from the ethanolic extract of Vernonia elaeagnifolia. Vernonia elaeagnifolia whole plant was collected and extracted with ethanol by soxhlation. Dried ethanolic extract of Vernonia elaeagnifolia was used to formulate the nanosuspension by homogenization method to enhance the bioavailability of phytoconstit...
1060
661
CHARACTERIZATION OF BIOLOGICALLY ACTIVE FRACTIONS OF METHANOL EXTRACT OF MATURE LEAVES OF POGOSTEMON BENGHALENSIS (BURM. F.) KUNTZE AND PERILLA FRUTESCENS (L.) BRITTON
The aim of the study was to determine the biologically active fractions of methanol extracts of mature leaves of Pogostemon benghalensis (burm. f.) Kuntze and Perilla frutescens L. Britton. The methanol extract was broadly fractionated sequentially in hexane, chloroform, acetone, ethyl acetate, and methanol. Activity index was recorded higher in methanol broad fractions of both of the plants. Broa...
999
579
HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LINN. AGAINST PARACETAMOL INDUCED LIVER DAMAGE IN ALBINO RATS
Chenopodium album Linn. is a plant that has a long history of uses in liver disorders. This study was done to evaluate the hepatoprotective effects of methanolic extract of Chenopodium album leaves on paracetamol-induced hepatotoxicity in albino rats. The hepatoprotective effect was evaluated on the basis of liver function parameters viz. Serum glutamic oxaloacetic transaminase (SGOT), Serum gluta...
1101
593
DETERMINATION OF DRUG TOXICITY OF ACETAMINOPHEN USING 3D SCAFFOLD CULTURES OF IMMORTAL HUMAN HEPATOCARCINOMA CELL LINES
Acetaminophen (APAP), well-known as paracetamol, is a safe analgesic and antipyretic agent at a therapeutic dose. However, overdoses of APAP can induce hepatotoxicity, which in turn causes severe liver injury. Various hepatic models mimicking liver architecture have been investigated to examine the potential hepatotoxic effects of chemicals and drugs, but there is always a demand for in-vitro hi...
988
570
FORMULATION AND EVALUATION OF CLARITHROMYCIN – LOADED SELF – MICRO EMULSIFIED DRUG DELIVERY SYSTEM
Clarithromycin is a lipophilic and poorly water-soluble macrolide antibiotic which belongs to class II of the biopharmaceutics classification system. Its oral absorption and related bioavailability are dissolution rate-limited and relatively low. Subsequently, the formulation of oral clarithromycin delivery systems poses a huge challenge to the formulation scientist. Utilization of self - micro em...
1936
778
APPLICATION OF SMARTPHONE AND DEVELOPMENT OF COLOUR KIT FOR THE ESTIMATION OF DOXYCYCLINE IN PHARMACEUTICAL DOSAGE FORMS AND ITS COMPARISON WITH A VALIDATED DIFFERENCE SPECTROSCOPIC METHOD BY UNCERTAINTY
In the proposed research paper, a simple, accurate, and precise colorimetric method has been developed for the estimation of doxycycline in bulk and pharmaceutical dosage forms. The proposed method utilizes a smartphone camera and an application instead of the UV spectrophotometer for the measurement of color intensity. This colorimetric method was found to be linear in the range of 10µg/ml to 50...
1010
666
BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES FROM CEIBA PENTANDRA (L.) GAERTN BARK AND EVALUATION OF ITS ANTIBACTERIAL AND ANTICANCER ACTIVITY
The present investigation was aimed at synthesis, characterization and in-vitro antibacterial and anticancer activities of synthesized gold nanoparticles using bark extract of Ceiba pentandra (L.) Gaertn. The synthesized AuNPs were confirmed by a UV-vis spectrometer through observing the surface plasmon resonance peak at 535 nm. Various other techniques, such as Fourier transform infrared spectros...
1144
663
VALIDATED STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF CAPECITABINE
A new stability-indicating high-performance liquid chromatographic method of analysis of capecitabine in pharmaceutical dosage form was developed and validated. The solvent system consisted of methanol: water (60:40% v/v). The retention time of capecitabine was 7.927 min at a flow rate of 1 ml/min on C-18 (Quails BDS, 250 × 4.6 mm, 5µ). Capecitabine was detected at 240 nm. The linear regression ...
1297
861
TECOMELLA UNDULATA (SM.) SEEM.- GC-MS ANALYSIS OF FLAVONOIDS AND INHIBITORY ACTIVITY AGAINST PATHOGENIC MICROBES
Tecomella undulata (Sm.) seem is a monotypic genus belonging to family Bignoniaceae. The plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders, to name a few. The plant has gained prominence due to the presence of some prominent secondary metabolites. The present study focuses on the GC-MS analysis of ...
1132
746
SIMULTANEOUS ESTIMATION OF VELPATASVIR AND SOFOSBUVIR IN BULK AND COMBINED TABLET DOSAGE FORM BY A SIMPLE VALIDATED STABILITY INDICATING RP-HPLC METHOD
A Simple, sensitive, specific and stability indicating RP-HPLC method was developed for the simultaneous estimation of velpatasvir and sofosbuvir in bulk and tablet dosage form. Effective separation attained by injecting 10 μL of the standard solution containing velpatasvir and sofosbuvir into Xbrdige Phenyl (250 × 4.6 mm, 5 µ, 100 A0) column, with a mobile phase containing methanol, buffer (0....
1750
718
IN-VITRO IMMUNOMODULATORY AND CYTOTOXICITY POTENTIAL OF NATURAL COMPOUNDS FROM FRAGARIA NUBICOLA
Introduction: Reactive oxygen species and nitric oxide play a major role in the physiopathology of inflammatory diseases, neurodegenerative disorders, autoimmune pathologies and immunodeficiency. With this understanding targeting oxidative stress could be a promising approach in new drug discovery. Methodology: Therefore, new compounds that were isolated from methanolic extract of leaves of wild s...
986
693
DEVELOPMENT AND EVALUATION OF MOXIFLOXACIN HYDROCHLORIDE LOADED POLY LACTIC-CO-GLYCOLIC ACID NANOPARTICLES FOR OCULAR DRUG DELIVERY
In general, ocular efficacy is strongly related to ocular drug bioavailability, which may be enhanced by prolonging precorneal drug residence time and increasing corneal drug penetration. Hence, the present study involves the development, characterization and evaluation of biodegradable moxifloxacin hydrochloride nano-particles intended for ocular use. Nano-particles were prepared by nano-precipit...
1274
788
ACUTE AND SUB ACUTE TOXICITY STUDY OF HYDROALCOHOLIC EXTRACT OF UNANI FORMULATION: (MAJOON HAJRUL YAHOOD) USED IN UROLITHIASIS
Background: Majoon hajrul yahood is a polyherbomineral formulation commonly used in the Unani system of medicine for the management of urolithiasis. In this study safety of a hydroalcoholic extract of majoon hajrul yahood was evaluate in Wistar rats. Materials and Methods: The hydroalcoholic extract of the formulation were tested for acute and sub-acute toxicity study. The single-dose (300, 2000, ...
1208
849
FORMULATION AND EVALUATION OF ENTERIC COATED ELEMENTARY OSMOTIC PUMP (ECEOP) TABLETS OF DICLOFENAC SODIUM
The objective of this study was to formulate a Novel drug delivery device that is capable of releasing the drug in controlled kinetics through the oral route, bypassing the acidic environment of the stomach. Therefore, it was planned to develop an osmotic device with an enteric coating. It was projected to enhance the strength of the semi-permeable membrane for the osmotic device to control drug r...
1763
949
ISOLATION OF STARCH FROM CURCUMA LONGA L. AND ITS CHARACTERIZATION
The present work was aimed to evaluate the different properties of turmeric starch. Starch has been an endless subject of research for many years. It is an inexpensive, readily available compounds with considerable applications in the food as well as non-food. Turmeric starch was isolated from fresh rhizomes of Curcuma longa L. and Curcuma Caesia (Zingiberaceae). In this article, we established an...
2289
925
IMPACT OF CLINICAL PHARMACIST DELIVERED EDUCATION AMONG TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE HOSPITAL
Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia. The aim is to study the impact of clinical pharmacists delivered education among type 2 diabetes mellitus patients in a tertiary care hospital. A prospective, interventional, randomized control study was carried out over a period of 6 months in the general medicine department of a tertiary care...
1527
807
FORMULATION OF EMULSIONS FROM PLANT ESSENTIAL OILS AGAINST MICROBIAL BIOFILMS
A biofilms are sessile aggregate mode of growth in some bacteria, fungi, protozoa, and algae which makes the microorganism tolerant to adverse environmental conditions biofilm-forming microorganism may possibly create conditions including native valve endocarditis, osteomyelitis, dental caries, middle ear infections, medical device-related infections, ocular implant infections and chronic lung inf...
2066
829
EVALUATION OF ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC ROOT EXTRACTS OF WITHANIA SOMNIFERA, BOERHAAVIA DIFFUSA AND THEIR COMBINATION IN DEXAMETHASONE INDUCED DIABETIC RATS
Diabetes mellitus is one of the major public health problems throughout the world. Current therapies, especially synthetic drugs, often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate the antidiabetic activity of such herbal extracts of roots of Withania s...
1206
802
ASSESSMENT OF PHYSICO-CHEMICAL PROPERTIES OF RIVER RAMGANGA WATER QUALITY IN MORADABAD AND BAREILLY REGION OF UTTAR PRADESH, INDIA
Ramganga river water is an important source of irrigation in major parts of the Moradabad and Bareilly region. The current study focuses on the assessment of the water quality of this river. River water samples were collected from five different sites of Moradabad and Bareilly stretch during the summer and winter season of the year 2018. Two sampling sites, namely MDA colony (S1) and Nawapuranalla...
1407
640
A STUDY ON IDENTIFICATION OF RISK FACTORS OF POLYCYSTIC OVARIAN SYNDROME BY CONDUCTING SURVEY AND MINIMIZING THEM THROUGH PATIENT COUNSELING AND ITS IMPACT ON QUALITY OF LIFE
Background: Polycystic ovarian syndrome (PCOS) is a very common Endocrine Disorder encountered in women in which there is an imbalance of female sex hormones. It is associated with problems such as menstrual irregularities, Hirsutism, Obesity, Insulin resistance, acne, and in later life infertility with Diabetes mellitus and uterine cancer. Objectives: 1. Identify the subjects who are at risk for ...
1848
953
SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON NITROGEN AND OXYGEN-BASED BI DENTATE MANNICH BASE LIGAND OF TRANSITION METAL COMPLEXES
1-{3-[2, 3dihydro-1H-imidazol-1-yl (8-hydroxyquinolin-7-yl) methyl] phenyl-l} ethanon, nitrogen and oxygen-based bi-dentate mannich base heterocyclic ligand synthesized and complexed with biologically significant transition metals like copper, cobalt, nickel, and zinc by the melt condensation three-component one-pot synthesis. All the synthesized potential compounds characterized by spectral metho...
993
592
IN-VITRO MUTAGENIC AND CYTOTOXIC ACTIVITY OF NIGELLA SATIVA SEED EXTRACT BY AMES AND MTT ASSAY
In the modern lifestyle, people are prone to disease. The epidemiology study shows that the lung and colon cancer leading position in both the gender around the world at any group. As based on the traditional systems of medicine, the plants can be used for the discovery of new medicine. The aqueous and ethanol extract of Nigella sativa (N. sativa) seeds were evaluated for their genotoxicity using ...
1090
641
ISOLATION AND CYTOTOXIC POTENTIAL OF SILVER NANOSUSPENSION OF THE ROOTS OF APHANAMIXIS POLYSTACHYA
Objective: The study was aimed to isolate the components from the methanolic extract of the root bark of Aphanamixis polystachya and to confirm their potential cytotoxicity of the methanolic extract, silver nanoparticles and silver nanosuspension of the root bark of A. polystachya. Method: Isolation from the methanolic extract of root barks of A. polystachya were performed using column chromatogra...
1109
660
TOXICITY EVALUATION AND OXYGEN CONSUMPTION STUDIES ON THE FISH CTENOPHARYNGODON IDELLA EXPOSED TO λ-CYHALOTHRIN 5% EC
The natural physiological functioning of an organism gets disturbed on exposure to toxicant stress. Toxicants affect first at cellular levels. It ultimately causes physiological, pathological, and biochemical alterations in an organism. Present study λ-Cyhalothrin of 5% EC formulation pyrethroid was used static renewal bioassay to evaluate 96 h LC50 in the freshwater fish Ctenopharyngodon idella ...
2435
711
EFFECTS OF AQUEOUS FRUIT EXTRACT OF HARITAKI (TERMINALIA CHEBULA) ON REGULATION OF HYPOTHYROIDISM
The thyroid, an important part of the human endocrine system, is involved in the regulation of oxygen use, basal metabolic rate, cellular metabolism, and growth. As it acts as a regulator for the body, abnormalities of the thyroid should be reckoned with, and measures to prevent such occurrences should be followed. Hypothyroidism can be described as the inability of the thyroid gland to produce su...
2940
849
CINNAMALDEHYDE, THE MAJOR COMPONENT OF CINNAMOMUM ZEYLANICUM, AFFECTS INFLAMMATORY PATHWAYS
Cinnamaldehyde is the aldehyde that gives cinnamon its flavour and odour. It occurs naturally in the bark of cinnamon tree (Cinnamomum zeylanicum), a common Indian spice. The essential oil of cinnamon bark contains about 90% of cinnamaldehyde. It exists as a yellow oily liquid with a cinnamon odor and sweet taste and is traditionally known to have many medicinal properties, although the mechanism ...
2952
777
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF MANGIFERIN AND BERBERIN HCL IN BULK AND SYNTHETIC MIXTURE
Introduction: There are so many promising plant-based chemical constituents are present which act as an alternative therapy for the control of diabetes. But due to the lack of its proper quality control parameters, they are not widely used. The USFDA patent is approved for a fixed dosage combination of Mangiferin (MF) and Berberin HCl (BER) as antidiabetic herbal formulation. Objective: The litera...
1144
602
DESIGN, FORMULATION AND OPTIMIZATION OF RUTIN TRIHYDRATE EMULGEL BY RESPONSE SURFACE METHODOLOGY
Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is a BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated ...
1358
786
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STANDARDIZATION OF TUBEROUS ROOT OF SMILAX CHINA L.
In this study, the pharmacognostic and phytochemical standardization of tuberous roots of Smilax china L. belongs to the Family Liliaceae was performed in detail. Pharmacognostical standardizations like macroscopical and microscopical studies, powder microscopy, quantitative microscopy, physicochemical analysis, fluorescence study, determination of heavy metal contamination, qualitative and quanti...
2019
801
EVALUATION OF ANTIHYPERGLYCEMIC ACTIVITY OF THE POLYHERBAL AND ALLOPOLYHERBAL FORMULATION ON NICOTINAMIDE-STREPTOZOTOCIN-INDUCED TYPE-2 DIABETIC RATS
Amla, Arjuna, Gudmar, Guduchi, and Ginger have been usually used in the traditional system of medicine for the treatment of diabetes. The aim of the present study to evaluate antihyperglycemic activity of polyherbal and allopolyherbal formulation on Streptozotocin-Nicotinamide (STZ-NA) induced type-2 diabetes rats. All the extracts of herbs used for the present study were obtained by supercritical...
1133
743
LITHIUM CHLORIDE RESCUES RETINAL GANGLION CELLS IN RAT MODEL OF GLUTAMATE EXCITOTOXICITY
Retinal ganglion cell (RGC) death is distinctive of many ophthalmic disorders, such as glaucoma, optic neuropathies, and various retinovascular diseases. N-methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR)-mediated excitotoxicity is thought to be an important contributor to RGC death. Uninterrupted activation of a large number of NMDARs leads to increases in intracellular calcium loads, in...
1055
582
THE POTENTIAL ROLE OF NANOTECHNOLOGY TO CONTROL OF INDUSTRIAL BIOFILM
In recent years, most researchers and interesting ones in the field of microbial biofilm documented that nanoparticles like silver, metal ions play a significant role in the biofilm approach. Here i would like to draw your attention to the modern technique in biofilm and the role of nanotechnology in combating medical resistant microbial infection. It is now realized that most bacterially derived ...
1095
561
ANTIMICROBIAL ACTIVITY OF FUSARIUM OXYSPORUM, ENDOPHYTIC FUNGUS, ISOLATED FROM PSIDIUM GUAJAVA L. (WHITE FRUIT)
The endophytic fungi isolated from the medicinal plant are an essential part of the current drug discovery from natural products. The endophytic fungus isolated from the healthy leaves of Psidium guajava was identified based on microscopic and cultural characteristics. The phylogenetic analysis inferred based on the internal transcribed spacer rRNA region sequence showed close similarity to Fusari...
1562
882
PHENOTYPIC AND MOLECULAR DETECTION OF CARBAPENEMASE NEW DELHI METALLO BETA LACTAMASE-1 (NDM-1) GENE AMONG PSEUDOMONAS AERUGINOSA FROM VARIOUS CLINICAL ISOLATES
Pseudomonas aeruginosa is an opportunistic pathogen which acquires resistance to antibiotics such as carbapenems and cefepime. Information regarding (NDM-1) gene producing Pseudomonas aeruginosa is available, but data regarding their degree of infection and percentage in hospital settings are scarce. Hence, this study was carried out to determine the occurrence of blaNDM-1 gene among clinical isol...
1129
871
ADDUCTOR CANAL BLOCK A NEW INTERVENTION OF URVI MARMA IN AYURVEDA
Ayurveda literally meaning the ‘science of life’ believes a completely normal state of health. Marma is one of the important sciences of treatment; described in the various ancient text of Ayurveda. The life force energy i.e. Prana is concentrated at the vital points in the body known as Marma. Urvi Marma is a Vaikalyakara type of Marma situated in the lower limb in the middle of the thigh, i....
1302
746
EXPRESSION PATTERN OF BETA DEFENSIN-3 IN THE SMALL INTESTINE OF ZEBRA FISH DANIO RERIO
The vertebrate immune system is composed of numerous distinct and interdependent components, and it consists of both systemic and mucosal immune compartments, but the mucosal immune system which protects the body from the first encounter of pathogens. β-defensins are a group of cysteine-rich cationic antimicrobial peptides that play an antimicrobial roles in the immune systems of vertebrates. Ver...
1046
499
FORCED DEGRADATION STUDY OF DARUNAVIR ETHANOLATE AND RITONAVIR COMBINATION IN ACIDIC, BASIC AND OXIDATIVE CONDITIONS ESTABLISHING DEGRADATION PRODUCTS
A simple, precise, and rapid stability indicating RP-HPLC method has been developed for the simultaneous estimation of darunavir ethanolate and Ritonavir in Pharmaceutical dosage form in the presence of degradation products. It involved the Zorbax bonus, 150 mm × 4.6 mm of 3.5 μm particles packing stationary phase. The separation was achieved using mobile phase a consists of ammonium acetate buf...
1469
671
A STUDY ON SERUM TOTAL BILIRUBIN AND URIC ACID IN NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS
Background: Serum total bilirubin (SBT) and serum uric acid (SUA) have anti-oxidant properties. SBT and SUA may be potential biomarkers for type 2 diabetes mellitus (T2DM) and its complications. Aim: It is aimed to evaluate the level of STB and SUA in T2DM. Materials and Methods: In this case-control study, a total of 124 subjects (62 T2DM cases and 62 age and gender-matched controls) were recruit...
1269
667
IN-VITRO EVALUATION OF ANTI-HELICOBACTER PYLORI ACTIVITY OF COMMERCIALLY AVAILABLE PROBIOTICS
Helicobacter pylori is a major etiological agent responsible for several gastric diseases such as gastritis, peptic ulcer disease, and gastric cancer. From the last two decades, standard triple therapy is mostly recommended for H. pylori eradication; however, its efficacy is restricted by antibiotic resistance. Hence, the present study aimed at exploration for novel therapeutic agents being warran...
1191
647
PHYTOCHEMICAL EVALUATION AND DETERMINATION OF ANTIOXIDANT ACTIVITY IN DIFFERENT PARTS OF AEGLE MARMELOS
Free radicals are unstable molecules that are formed during normal cell metabolism through chemical changes that take place in a cell. This causes damage to cellular components such as cells, proteins, and DNA, or the cell membrane. Free radicals play a role in a complex interplay of different mechanisms in both normal agings, neurodegenerative, and other diseases. Aqueous and methanolic solvent ...
1309
1922
ANTIBIOTICS SUSCEPTIBILITY IN CHRONIC SUPPURATIVE OTITIS MEDIA (CSOM) AT THE SECONDARY CARE HOSPITAL IN NORTH INDIA
Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear cleft with a perforated tympanic membrane and draining exudate for more than 6weeks. Information about the organism responsible for COSM and their antibiotic susceptibility is important for effective treatment. Material and Methods: A prospective cross-sectional study was conducted on 85 pati...
1058
519
SOCIO DEMOGRAPHIC CHARACTERISTICS OF LUNG CANCER PATIENTS IN NORTH MALABAR REGION OF KERALA, SOUTH INDIA
Background: Lung cancer is the most common malignant neoplasm worldwide, accounting for greater mortality than due to any other cancer. It accounts for about 13% of all new cancer cases and 19% of cancer-related deaths worldwide. In India, lung cancer comprises 6.9% of all new cases of cancer and 9.3% of all cancer-related mortality in both sexes. This study aimed to find out the socio-demographic...
1045
627
IN-VITRO INSIGHT INTO THE IMPACT OF DIABETES AND IMPLANT DEBRIS ON ORTHOPEDIC IMPLANT
Wear particle evoked lysis limits the long-run survivorship of total joint replacement (TJR) in polygenic disease. Monocyte / macrophages area the key cells of this adverse reaction. The aim of this study was to come up with useful human osteoclasts (OCs) in-vitro from sort a pair of diabetes (T2D) and health management to research the potential osteoclastogenic role of T2D and implant detritus in...
886
454