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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Volume 11 (2020) - Issue 11, November

Review Articles

 
Title
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1.

TARGET BASED PHARMACOLOGICAL APPROACHES FOR DRUG DEVELOPMENT AGAINST NOVEL CORONA VIRUS (COVID-19)

The novel coronavirus (COVID-19) outbreak has covered almost 185 countries worldwide, causing infection to 32, 50,000 people and the death of approximately 2, 30,000 people to date. World Health Organisation (WHO) has declared it a pandemic that seems to be unstoppable as no vaccine or drug is available as of now to kill the virus. Several research labs are trying to develop a vaccine against the ...

Q. Hoda *, A. Fatma, S. Pahwa and C. Gupta

Department of Pharmacy, Lloyd Institute of Management and Technology, Knowledge Park-II, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5284-89

5284-5289

663

342

2.

HYDROXYCHLOROQUINE (HCQ) AS AN EMERGING AND PROMISING DRUG CANDIDATE IN COVID-19 PANDEMIC – A SYSTEMATIC REVIEW

Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of...

S. Saini *, P. Chauhan and Babita

Abhilashi College of Pharmacy, Nerchowk, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5290-97

5290-5297

386

156

3.

MITOGENIC, ANTIOXIDATIVE AND ANTIMICROBIAL ACTIVITIES OF G-90 AND COELOMIC FLUID FROM EARTHWORM AS A THERAPEUTIC AGENT, A REVIEW

The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part. These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid. The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication. The antimicrobial a...

K. Gudeta *, S. Kumari, A. Bhagat, J. M. Julka and R. Goyal

Faculty of Biological and Environmental Sciences, Shoolini University Biotechnology and Management Sciences, Solan, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5298-07

5298-5307

325

127

4.

A REVIEW OF SOME MEDICINAL PLANTS ON THEIR ANTIULCER AND ULCER HEALING POTENTIAL

The imbalance between aggressive (pepsin, Hydrochloric acid­) and protective elements (bicarbonate and mucosa) in the inner lining of the stomach lead to the formation of peptic ulcers. The presence of Body fluids, mucosal hydrophobicity, fast epithelial cell recharging, and rich mucosal blood flow is involved in mucosal protection of the Stomach. Prostaglandins E2 and I2 are the predominant pros...

B. Chaudhary, M. S. Saxena *, S. Sharma, B. Ansari and Mohseen 

Sunderdeep Pharmacy College, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5308-21

5308-5321

301

129

5.

PLANT-BASED TRADITIONAL REMEDIES FOR SNAKEBITE IN INDIA: A RECENT UPDATE REVIEW

Medicinal plants are a potential source of therapeutic drugs and play a central role in the health care system throughout the world. Plants have been an integral part of the life of many indigenous communities. Snakebite is a neglected tropical disease. Snakebite remains a major health concern throughout the world, especially in India. The highest Morbidity and Mortality occurs in rural and tribal...

S. Pullani and A. L. Prabha *

Department of Botany, Bharathidasan University, Tiruchirapalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5322-33

5322-5333

1710

571

6.

PEPTIC ULCEROGENESIS: ETIOLOGY, PATHOGENESIS AND VARIOUS CLINICAL ASPECTS

“Eat to live and don’t live to eat” this is a principle to be followed for a healthy and wealthy life. According to the therapeutic point of view, the patient who suffers from peptic ulcer diseases was shown to have a reduced secreted amount of HCl and pepsin. The management of gastric and duodenal ulcers can be followed by the decreased or neutralized level of gastric acid. Peptic ulcer inf...

S. Chandra *, A. Srivastava and K. Manwani

Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5334-45

5334-5345

82

48

7.

DIVERSE STRATEGIES TO BOOST UP SOLUBILITY OF POOR WATER SOLUBLE DRUGS – A REVIEW

As we understand that for achieving a supportive effect in the human body, the prescription should be bioavailable, and in this way, it depends upon the dissolvability of the drug. Starting late 40% of the meds are inadequate water dissolvable, which produces responses, for instance, gastric exacerbation, peptic ulceration, etc. An oral course of medication organization is the most favored defeat ...

M. A. H. Malek and P. M. Patel *

Department of Industrial Chemistry, V.P. & R.P.T.P. Science College, Affiliated to Sardar Patel University Vallabh Vidyanagar, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5346-59

5346-5359

397

46

8.

REVIEW ON MICROSPONGE LEADING MICROPOROUS PARTICULATE TECHNOLOGY WITH CONTROLLED RELEASE, IMPROVE STABILITY TO PROVIDE OPTIMUM SKIN DISORDERS MANAGEMENT ENVIRONMENT FOR THERAPEUTIC APPLICATION

Although serious systemic and cutaneous side effects need a novel delivery system that provides prolonged and controlled drug release, minimum systemic drug absorption with reduced side effects. Microsponge, a drug delivery system, possesses the versatility to load a wide range of active ingredients to facilitate the controlled release of active ingredients to reduce systemic exposure and to reduc...

N. Tomar, N. Pawar * and K. Bahmani

Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5360-75

5360-5375

86

52

9.

HERBONANOCEUTICALS: A NEWER APPROACH FOR DELIVERING HERBAL DRUGS

“Nanotechnology” is a science which deals with the particles less than the size of 100 nm. Materials at the atomic and molecular scales are engineered and manufactured by this technology. The use of nanotechnology for “phytotherapy” or treatment of various diseases by herbal medicines/drugs, including herbal drug delivery, where current and emerging nanotechnologies could enable entirely n...

A. D. Khan *, R. Kaushik, K. Sharma and P. Kesharwani

Department of Pharmaceutics, RamEesh Institute of Vocational and Technical Education, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5376-85

5376-5385

79

49

10.

ORAL LIPID BASED DRUG DELIVERY SYSTEM: A REVIEW

In the recent progressive era of pharmaceutical technology, newly investigated most of the drugs come under BCS class II and IV having low solubility as well bioavailability. The drugs are not suitable candidate for the conventional oral delivery of drug. The reason is that the drugs are not able to dissolve in aqueous environment of GI (gastrointestinal) tract. Poor water solubility of drug is ch...

R. Khatri, U. Varia *, H. Katariya and K. Detholia

Department of Pharmaceutics, Smt. S. M. Shah Pharmacy College, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5386-03

5386-5403

101

47

11.

FORMULATION AND EVALUATION OF GASTRO-RETENTIVE FLOATING MICRO-SPHERES: A SYSTEMATIC REVIEW

Gastro-retentive drug delivery system is the novel controlled release system that overcomes the problem like the first-pass metabolism, narrow index of absorption, unstable in intestinal pH, low bioavailability. Different approaches to GRDDS are floating, mucoadhesive, swelling, high density, magnetic drug delivery system. The floating drug delivery system is the most promising approach. The dosag...

N. Kulkarni *, M. Kulkarni, J. Rathod and N. S. Dhole

Department of Pharmaceutics, P. E. S. Modern College of Pharmacy (For Ladies), Moshi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(1).5404-16

5404-5416

90

47

12.

A REVIEW ON THE ROLE OF NATURAL REMEDIES IN PSORIASIS THERAPY

Psoriasis is a chronic inflammatory disease that affects about 1-2% population. It is caused by different factors, the most common cause being genetic predisposition. Other causes or factors that can trigger psoriasis include infection, physical trauma to the skin, stress and certain medication, for example, beta-blockers and antimalarials. People suffering from psoriasis are at a greater risk of ...

P. Derera and M. Sumithra *

Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, Kanchipuram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5417-24

5417-5424

72

41

13.

A REVIEW ON THE ANTIBACTERIAL POTENTIAL OF INVASIVE WEEDS USED FOR THE TREATMENT OF CARBUNCLE IN PURULIA DISTRICT OF WEST BENGAL INDIA

Carbuncle is a serious skin disease that affects tribal communities very quickly. The disease is generally caused by Staphylococcus aureus, Escherichia coli, or Streptococcus pyogens. Due to increasing drug resistance in these bacterial strains, it has become very difficult to treat carbuncle with modern antibiotics. The information about tribal peoples using invasive weeds to treat carbuncle is e...

A. Bera, S. Maiti and N. Banerjee *

Department of Botany and Forestry, Vidyasagar University, Midnapore, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5425-33

5425-5433

71

36

14.

AN OVERVIEW OF OVARIAN CYSTS

To study various types of the benign cyst, differential diagnosis, diagnosis for identification of cyst, suitable treatment options based on various types of cysts that are occurring in the ovaries. An ovarian cyst is a commonly occurring mass in reproductive-age women. Functional ovarian cysts are physiologic and usually dissolve spontaneously within a couple of menstrual cycles. A combination of...

M. Rana and P. Nasa *

Department of Pharmaceutical Education and Research, Bhagat Phool Singh Mahila Viswavidyalaya, Sonipat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5434-40

5434-5440

118

44

15.

THERAPEUTIC SIGNIFICANCE OF INDOLE SCAFFOLD IN MEDICINAL CHEMISTRY

Discovery of New Chemical Entities (NCEs) is the result of a series of high throughput screening process after the successful design and synthesis scheme. The indole nucleus is an important heterocyclic compound containing nitrogen, and it has been a source of vital therapeutic agents. It is noteworthy in recent advances of synthetic, medicinal chemistry; the last decade has been witnessed with a ...

K. Hussain, M. J. Alam, A. Hussain and N. A. Siddique *

Bioactive Natural Compound, Laboratory (BNCL), Department of Pharmacognosy and Phytochemistry, Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5441-60

5441-5460

100

49

Research Articles

 
Title
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16.

IN-VITRO AND IN-VIVO SYNERGISM BETWEEN VALSPODAR (PSC833) AND ANTIBIOTICS AGAINST STAPHYLOCOCCUS AUREUS STRAINS

Here, we report the in-vitro and in-vivo effects of Valspodar (PSC833), a second-generation mammalian efflux pump inhibitor on the susceptibility of methicillin-resistant and methicillin-sensitive Staphylo-coccus aureus (MRSA and MSSA) towards two antibiotics, Oxacillin (OX) and Cefoxitin (FOX). Checkerboard microdilution assays revealed various degrees of strain-dependent synergy demonstrated in ...

R. Jabr, N. A. Qinna and S. M. A. Abdelmalek *

Department of Pharmacology and Biomedical Sciences, University of Petra, Amman, Jordan.

DOI: 10.13040/IJPSR.0975-8232.11(11).5461-68

5461-5468

254

133

17.

HELICOBACTER PYLORI INFECTION: A BIOINFORMATIC APPROACH

Helicobacter pylori causative agent of acid peptic disease is a microaerophilic, spiral-shaped, gram-negative bacteria found in the gastric epithelium that may also lead to complications such as chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, gastroduodenal ulcer and adenocarcinoma in stomach. Plantbioactives have always been potential therapeutics. Usage of modern bioinform...

A. Prasad, G. Shruthi, P. Sushma, A. S. Jain, D. Chandan, M. N. N. Prasad, S. P. Kollur, C. Srinivasa and C. Shivamallu *

Division of Biotechnology and Bioinformatics, Department of Water & Health, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5469-83

5469-5483

250

89

18.

INCREASED PROPERTIES AND CITOCOMPATIBILITY OF ZINC OXIDE-MAGNESIUM CEMENT

Zinc oxide-magnesium has been used in dentistry with limitations especially related to its high acidity and low biocompatibility. The objective of this study was to develop cement based on nano-hydroxyapatite (nHA), chitosan as more biocompatibility agents to increase zinc oxide-magnesium cito-compatibility. The formulations prepared were: 1. Complete cement (HCP) with nHA, zinc oxide-magnesium, a...

G. C. Paula, A. Trajano, A. D. Pinzón-García, R. D. Sinisterra and M. E. Cortes *

Universidade Federal de Minas Gerais, Faculty of Dentistry, Restorative Dentistry Department, Belo Horizonte, Minas Gerais, Brazil. Av. Antônio Carlos, Pampulha, Belo Horizonte, MG, Brazil.

DOI: 10.13040/IJPSR.0975-8232.11(11).5484-96

5484-5496

280

101

19.

QUALITY BY DESIGN APPROACH TO OPTIMIZE OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM

The present investigation deals with the development of the controlled porosity osmotic pump (CPOP) tablet of Garcinia indica fruit rind extract used in the management of colon cancer by implementing the concept of Quality by Design (QbD). The quality target product profile (QTPP) and Critical Quality Attributes (CQA) of the Garcinia indica tablets were defined based on preliminary studies. The ef...

P. C. Jagtap *, P. Vijayalakshmi and K. S. Bhise

Centre for Pharmaceutical Sciences, Jawaharlal Nehru Technological University Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5497-07

5497-5507

252

109

20.

A STATISTICAL APPROACH TO DEVELOPMENT OF SUSTAINED RELEASE PRONIOSOMAL MICONAZOLE NITRATE GEL

Miconazole nitrate is a broad-spectrum antifungal agent, and it is used for the treatment of superficial fungal infections. It has low skin permeability. Therefore, the aim of this study was to prepare proniosomal 2% miconazole nitrate sustained release to a treat deep-seated fungal infections. The different batches of proniosomal 2% miconazole nitrate gel were prepared by the conservation phase s...

N. A. Oza * and S. V. Sagar

C. U. Shah College of Pharmacy & Research, Surendranagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5508-17

5508-5517

221

101

21.

SYNTHESIS OF NEW 2, 5, 6-SUBSTITUTED IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS

A series of 2-cyclopropylimidazo [2,1-b] [1,3,4] thiadiazole derivatives 5(a-i) have been synthesized by reacting 5-cyclopropyl-1,3,4-thiadiazol-2-amine (3) and an appropriate 2-bromo-1,2-(substituted aryl) ethanones 4(a-i). Structures of these compounds were recognized by IR, 1H NMR, 13C NMR spectroscopy and Mass spectrometry. Hypoxia-inducible factor (HIF) has been identified as an important can...

N. S. Sethi, M. N. Noolvi *, V. Kharb, V. K. Nathubhai, U. A. More, S. P. Avvaru, B. J. Khairnar, S. Desai, B. S. Thippeswamy and F. A. Otaibi

Department of Pharmaceutical Chemistry, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5518-29

5518-5529

71

49

22.

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF NEBIVOLOL AND VALSARTAN

Better patient compliance can be achieved using a combination of two drugs compared to a single drug. The main objective of the present research work has been done to prepare fast dissolving tablets of Nebivolol HCl (NEB) and Valsartan (VAL) using super disintegrating agents. Solid dispersions of VAL were prepared with Mannitol to improve the solubility and release behavior in dissolution flui...

D. M. Patel *, D. J. Patel, S. K. Shah and A. S. Shah

Department of Pharmaceutics, Saraswati Institute of Pharmaceutical Sciences, Dhanap, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5530-39

5530-5539

87

39

23.

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR IDENTIFICATION AND QUANTIFICATION OF URSOLIC ACID IN THE LEAVES OF ALSTONIA SCHOLARIS

Herbs have been used since antiquity for treatment and management of various disease conditions. Their ability to cure or prevent diseases is due to storehouses of various phytoconstituents like alkaloids, flavonoids, glycosides, terpenoids, steroids, tannins, phenols, etc. present in them. Pentacyclic triterpenoids have gained greater attention of researchers due to its wide array of pharmacologi...

M. M. Sanaye * and S. Zehra

Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Colaba, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5540-46

5540-5546

74

39

24.

EVALUATION OF COGNITION ENHANCING ACTIVITY OF SESBANIA GRANDIFLORA (L.) FRUITS EXTRACT ON HIGH FAT DIET INDUCED DEMENTIA

The study was aimed to justify the traditional claim of fruits of Sesbania grandiflora (Leguminosae) as a medhya rasayana. Dementia was induced with chronic administration of a high fat diet for 90 days. Petroleum ether, benzene, chloroform, acetone, ethanol extracts of fruits of Sesbania grandiflora were evaluated for cognition-enhancing activity in high-fat diet-induced dementia in rats using an...

V. J. Mahadik * and K. A. Wadkar

Shree Santkrupa Shikshan Sanstha’s College of Pharmacy (D. Pharm), Ghogaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5547-52

5547-5552

77

38

25.

BIOACTIVE COMPOUND ANALYSIS AND BIOACTIVITIES OF ENDOPHYTIC BACTERIA FROM CISSUS QUADRANGULARIS

Endophytic bacteria were isolated from the stem of Cissus quadrangularis on Nutrient agar medium. The bacterial isolates were cultured in Nutrient broth. Ethyl acetate extracts of endophytic bacteria were evaluated for the presence of bioactive compounds and total phenolic content. The phytochemical screening of extracellular ethyl acetate extracts showed the presence of phenols. The total phenol ...

P. Z. Anwar, U. G. Sezhian * and A. Narasingam

Department of Plant Biology and Plant Biotechnology, Ethiraj College for Women (Autonomous), Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5553-60

5553-5560

84

41

26.

QUALITY BY DESIGN APPROACH TO OPTIMIZE OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM

The present investigation deals with the development of the controlled porosity osmotic pump (CPOP) tablet of Garcinia indica fruit rind extract used in the management of colon cancer by implementing the concept of Quality by Design (QbD). The quality target product profile (QTPP) and Critical Quality Attributes (CQA) of the Garcinia indica tablets were defined based on preliminary studies. The ef...

P. C. Jagtap *, P. Vijayalakshmi and K. S. Bhise

Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5561-71

5561-5571

51

36

27.

CHEMICAL COMPOSITION OF ESSENTIAL OIL OF EQUISETUM DIFFUSUM: A NOBLE SOURCE OF PHYTOL

Plants as a source of medicine have been inherited and are an important component of the health care system in India. Equisetum diffusum D. Don (Equisetaceae) is one of the medicinally important plants, which is a native species to the Himalayan Mountains. It is popularly known as Himalayan horsetail. The present endeavor deals with the exploration of the chemical composition of Himalayan E. diffu...

P. Takuli, K. Khulbe, P. Kumar * and C. Pant

Department of Botany, D.S.B. Campus, Kumaun University, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5572-78

5572-5578

71

39

28.

TOXICITY EVALUATION AND BEHAVIOURAL CHANGES OF LABEO ROHITA EXPOSED TO ETHION 50% EC

Modernization and intensification of agricultural production is generally accompanied by a rapid increase in the use of chemical fertilizers and pesticides. Ethion 50% EC is a broad-spectrum organophosphate insecticide used to control insects, mites, and nematodes by soil, foliar, and seed treatment applications, mainly on potatoes, sugar beet, rice, and maize, citrus. The aim of the present study...

C. Prasanna *, C. Anithasmruthi and V. V. Rathnamma

Department of Environmental Sciences, A.S.N Group of Institutions, Tenali, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5579-86

5579-5586

63

36

29.

FORMULATION AND EVALUATION OF VERNONIA ELAEAGNIFOLIA PHYTO-FORMULATION FOR THE MANAGEMENT OF HYPERLIPIDAEMIA

The aim of the present investigation was to formulate and evaluate phytoformulation prepared from the ethanolic extract of Vernonia elaeagnifolia. Vernonia elaeagnifolia whole plant was collected and extracted with ethanol by soxhlation. Dried ethanolic extract of Vernonia elaeagnifolia was used to formulate the nanosuspension by homogenization method to enhance the bioavailability of phytoconstit...

S. Nawale *, K. P. Laxmi, M. S. Bhargavi and M. G. Raju

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Osmania University, Bachupally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5587-94

5587-5594

73

37

30.

CHARACTERIZATION OF BIOLOGICALLY ACTIVE FRACTIONS OF METHANOL EXTRACT OF MATURE LEAVES OF POGOSTEMON BENGHALENSIS (BURM. F.) KUNTZE AND PERILLA FRUTESCENS (L.) BRITTON

The aim of the study was to determine the biologically active fractions of methanol extracts of mature leaves of Pogostemon benghalensis (burm. f.) Kuntze and Perilla frutescens L. Britton. The methanol extract was broadly fractionated sequentially in hexane, chloroform, acetone, ethyl acetate, and methanol. Activity index was recorded higher in methanol broad fractions of both of the plants. Broa...

J. Chetia * and L. R. Saikia

Department of Life Sciences, Dibrugarh University, Dibrugarh, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5595-04

5595-5604

65

44

31.

HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LINN. AGAINST PARACETAMOL INDUCED LIVER DAMAGE IN ALBINO RATS

Chenopodium album Linn. is a plant that has a long history of uses in liver disorders. This study was done to evaluate the hepatoprotective effects of methanolic extract of Chenopodium album leaves on paracetamol-induced hepatotoxicity in albino rats. The hepatoprotective effect was evaluated on the basis of liver function parameters viz. Serum glutamic oxaloacetic transaminase (SGOT), Serum gluta...

A. Das * and M. K. Borthakur

Department of Zoology, Gauhati University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5605-10

5605-5610

72

46

32.

DETERMINATION OF DRUG TOXICITY OF ACETAMINOPHEN USING 3D SCAFFOLD CULTURES OF IMMORTAL HUMAN HEPATOCARCINOMA CELL LINES

Acetaminophen (APAP), well-known as paracetamol, is a safe analgesic and antipyretic agent at a therapeutic dose. However, overdoses of APAP can induce hepa­totoxicity, which in turn causes severe liver injury. Various hepatic models mimicking liver architecture have been investigated to examine the potential hepatotoxic effects of chemicals and drugs, but there is always a demand for in-vitro hi...

M. S. Suma, K. S. Jamuna, C. K. Ramesh * and R. Mahmood

PG Department of Studies and Research in Biotechnology, Sahyadri Science College, Kuvempu University, Shimoga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5611-18

5611-5618

59

40

33.

FORMULATION AND EVALUATION OF CLARITHROMYCIN – LOADED SELF – MICRO EMULSIFIED DRUG DELIVERY SYSTEM

Clarithromycin is a lipophilic and poorly water-soluble macrolide antibiotic which belongs to class II of the biopharmaceutics classification system. Its oral absorption and related bioavailability are dissolution rate-limited and relatively low. Subsequently, the formulation of oral clarithromycin delivery systems poses a huge challenge to the formulation scientist. Utilization of self - micro em...

A. Bediako *, N. Kuntworbe, R. Johnson, M. T. Bayor and K. Ofori-Kwakye

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

DOI: 10.13040/IJPSR.0975-8232.11(11).5619-32

5619-5632

440

60

34.

APPLICATION OF SMARTPHONE AND DEVELOPMENT OF COLOUR KIT FOR THE ESTIMATION OF DOXYCYCLINE IN PHARMACEUTICAL DOSAGE FORMS AND ITS COMPARISON WITH A VALIDATED DIFFERENCE SPECTROSCOPIC METHOD BY UNCERTAINTY

In the proposed research paper, a simple, accurate, and precise colorimetric method has been developed for the estimation of doxycycline in bulk and pharmaceutical dosage forms. The proposed method utilizes a smartphone camera and an application instead of the UV spectrophotometer for the measurement of color intensity. This colorimetric method was found to be linear in the range of 10µg/ml to 50...

M. C. Trivedi and R. C. Mashru *

Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5633-42

5633-5642

63

37

35.

BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES FROM CEIBA PENTANDRA (L.) GAERTN BARK AND EVALUATION OF ITS ANTIBACTERIAL AND ANTICANCER ACTIVITY

The present investigation was aimed at synthesis, characterization and in-vitro antibacterial and anticancer activities of synthesized gold nanoparticles using bark extract of Ceiba pentandra (L.) Gaertn. The synthesized AuNPs were confirmed by a UV-vis spectrometer through observing the surface plasmon resonance peak at 535 nm. Various other techniques, such as Fourier transform infrared spectros...

M. O. Brian * and S. Selvi

PG and Research Department of Biochemistry, Bharathidasan College of Arts and Science, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5643-50

5643-5650

67

38

36.

VALIDATED STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF CAPECITABINE

A new stability-indicating high-performance liquid chromatographic method of analysis of capecitabine in pharmaceutical dosage form was developed and validated. The solvent system consisted of methanol: water (60:40% v/v). The retention time of capecitabine was 7.927 min at a flow rate of 1 ml/min on C-18 (Quails BDS, 250 × 4.6 mm, 5µ). Capecitabine was detected at 240 nm. The linear regression ...

K. V. Lalitha *, J. R. Reddy and N. Devanna

Division of Pharmaceutical Analysis and Quality Assurance, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5651-58

5651-5658

70

48

37.

TECOMELLA UNDULATA (SM.) SEEM.- GC-MS ANALYSIS OF FLAVONOIDS AND INHIBITORY ACTIVITY AGAINST PATHOGENIC MICROBES

Tecomella undulata (Sm.) seem is a monotypic genus belonging to family Bignoniaceae. The plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders, to name a few. The plant has gained prominence due to the presence of some prominent secondary metabolites. The present study focuses on the GC-MS analysis of ...

R. Bhardwaj * and R. A. Sharma

Department of Botany, IIS University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5659-68

5659-5668

62

37

38.

SIMULTANEOUS ESTIMATION OF VELPATASVIR AND SOFOSBUVIR IN BULK AND COMBINED TABLET DOSAGE FORM BY A SIMPLE VALIDATED STABILITY INDICATING RP-HPLC METHOD

A Simple, sensitive, specific and stability indicating RP-HPLC method was developed for the simultaneous estimation of velpatasvir and sofosbuvir in bulk and tablet dosage form. Effective separation attained by injecting 10 μL of the standard solution containing velpatasvir and sofosbuvir into Xbrdige Phenyl (250 × 4.6 mm, 5 µ, 100 A0) column, with a mobile phase containing methanol, buffer (0....

R. Godela * and G. Sowjanya

GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5669-78

5669-5678

94

44

39.

IN-VITRO IMMUNOMODULATORY AND CYTOTOXICITY POTENTIAL OF NATURAL COMPOUNDS FROM FRAGARIA NUBICOLA

Introduction: Reactive oxygen species and nitric oxide play a major role in the physiopathology of inflammatory diseases, neurodegenerative disorders, autoimmune pathologies and immunodeficiency. With this understanding targeting oxidative stress could be a promising approach in new drug discovery. Methodology: Therefore, new compounds that were isolated from methanolic extract of leaves of wild s...

S. Soomro*, M. A. Aljameeli and S. Sangi

Department of Basic Health Sciences, Faculty of Pharmacy, Northern Border University Rafha, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(11).5679-84

5679-5684

69

47

40.

DEVELOPMENT AND EVALUATION OF MOXIFLOXACIN HYDROCHLORIDE LOADED POLY LACTIC-CO-GLYCOLIC ACID NANOPARTICLES FOR OCULAR DRUG DELIVERY

In general, ocular efficacy is strongly related to ocular drug bioavailability, which may be enhanced by prolonging precorneal drug residence time and increasing corneal drug penetration. Hence, the present study involves the development, characterization and evaluation of biodegradable moxifloxacin hydrochloride nano-particles intended for ocular use. Nano-particles were prepared by nano-precipit...

M. D. Harshal *, W. D. Rajendra, B. T. Dheeraj, M. S. Hitendra and M. J. Bhushan

Department of Pharmaceutics, DCS’s A.R.A. College of Pharmacy, Nagaon, Dhule, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5685-93

5685-5693

64

39

41.

ACUTE AND SUB ACUTE TOXICITY STUDY OF HYDROALCOHOLIC EXTRACT OF UNANI FORMULATION: (MAJOON HAJRUL YAHOOD) USED IN UROLITHIASIS

Background: Majoon hajrul yahood is a polyherbomineral formulation commonly used in the Unani system of medicine for the management of urolithiasis. In this study safety of a hydroalcoholic extract of majoon hajrul yahood was evaluate in Wistar rats. Materials and Methods: The hydroalcoholic extract of the formulation were tested for acute and sub-acute toxicity study. The single-dose (300, 2000, ...

S. A. A. Makbul * and N. Jahan

Department of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5694-02

5694-5702

74

42

42.

FORMULATION AND EVALUATION OF ENTERIC COATED ELEMENTARY OSMOTIC PUMP (ECEOP) TABLETS OF DICLOFENAC SODIUM

The objective of this study was to formulate a Novel drug delivery device that is capable of releasing the drug in controlled kinetics through the oral route, bypassing the acidic environment of the stomach. Therefore, it was planned to develop an osmotic device with an enteric coating. It was projected to enhance the strength of the semi-permeable membrane for the osmotic device to control drug r...

S. Nandi *, P. Deb, J. Banerjee and K. H. Reza

Gitanjali College of Pharmacy, Lohapur, Birbhum, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5703-11

5703-5711

137

72

43.

ISOLATION OF STARCH FROM CURCUMA LONGA L. AND ITS CHARACTERIZATION

The present work was aimed to evaluate the different properties of turmeric starch. Starch has been an endless subject of research for many years. It is an inexpensive, readily available compounds with considerable applications in the food as well as non-food. Turmeric starch was isolated from fresh rhizomes of Curcuma longa L. and Curcuma Caesia (Zingiberaceae). In this article, we established an...

K. Nakkala *, S. Godiyal and K. S. Laddha

Medicinal and Natural Products Research Laboratory, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5712-17

5712-5717

78

47

44.

IMPACT OF CLINICAL PHARMACIST DELIVERED EDUCATION AMONG TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE HOSPITAL

Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia. The aim is to study the impact of clinical pharmacists delivered education among type 2 diabetes mellitus patients in a tertiary care hospital. A prospective, interventional, randomized control study was carried out over a period of 6 months in the general medicine department of a tertiary care...

A. K. Chaudhary, E. Eldho, S. James and M. Baby *

Department of Pharmacy Practice, Hillside College of Pharmacy and Research Center, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5718-24

5718-5724

220

171

45.

FORMULATION OF EMULSIONS FROM PLANT ESSENTIAL OILS AGAINST MICROBIAL BIOFILMS

A biofilms are sessile aggregate mode of growth in some bacteria, fungi, protozoa, and algae which makes the microorganism tolerant to adverse environmental conditions biofilm-forming microorganism may possibly create conditions including native valve endocarditis, osteomyelitis, dental caries, middle ear infections, medical device-related infections, ocular implant infections and chronic lung inf...

B. Anandhi, M. Subaharini, R. Abinaya and S. Ponnarmadha *

Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5725-32

5725-5732

69

35

46.

EVALUATION OF ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC ROOT EXTRACTS OF WITHANIA SOMNIFERA, BOERHAAVIA DIFFUSA AND THEIR COMBINATION IN DEXAMETHASONE INDUCED DIABETIC RATS

Diabetes mellitus is one of the major public health problems throughout the world. Current therapies, especially synthetic drugs, often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate the antidiabetic activity of such herbal extracts of roots of Withania s...

M. S. Mini, S. A. Krishnan * and K. Sridevi

School of Pharmaceutical Sciences and Technologies, JNTUK, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5733-40

5733-5740

63

44

47.

ASSESSMENT OF PHYSICO-CHEMICAL PROPERTIES OF RIVER RAMGANGA WATER QUALITY IN MORADABAD AND BAREILLY REGION OF UTTAR PRADESH, INDIA

Ramganga river water is an important source of irrigation in major parts of the Moradabad and Bareilly region. The current study focuses on the assessment of the water quality of this river. River water samples were collected from five different sites of Moradabad and Bareilly stretch during the summer and winter season of the year 2018. Two sampling sites, namely MDA colony (S1) and Nawapuranalla...

N. Javed, D. K. Prajapati, J. Singh, R. K. Gangwar and R. Deval *

Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5741-46

5741-5746

82

43

48.

A STUDY ON IDENTIFICATION OF RISK FACTORS OF POLYCYSTIC OVARIAN SYNDROME BY CONDUCTING SURVEY AND MINIMIZING THEM THROUGH PATIENT COUNSELING AND ITS IMPACT ON QUALITY OF LIFE

Background: Polycystic ovarian syndrome (PCOS) is a very common Endocrine Disorder encountered in women in which there is an imbalance of female sex hormones. It is associated with problems such as menstrual irregularities, Hirsutism, Obesity, Insulin resistance, acne, and in later life infertility with Diabetes mellitus and uterine cancer. Objectives: 1. Identify the subjects who are at risk for ...

S. Budharam, S. Veeramreddy, D. S. Goluguri and A. Rajani *

Department of Pharmacy Practice, MNR College of Pharmacy, Sangareddy, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5747-52

5747-5752

52

35

49.

SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON NITROGEN AND OXYGEN-BASED BI DENTATE MANNICH BASE LIGAND OF TRANSITION METAL COMPLEXES

1-{3-[2, 3dihydro-1H-imidazol-1-yl (8-hydroxyquinolin-7-yl) methyl] phenyl-l} ethanon, nitrogen and oxygen-based bi-dentate mannich base heterocyclic ligand synthesized and complexed with biologically significant transition metals like copper, cobalt, nickel, and zinc by the melt condensation three-component one-pot synthesis. All the synthesized potential compounds characterized by spectral metho...

A. M. Anusuya * and B. S. Krishna

Department of Chemistry, Sapthagiri College of Engineering Affiliated to Visveswaraya Technological University, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5753-59

5753-5759

62

43

50.

IN-VITRO MUTAGENIC AND CYTOTOXIC ACTIVITY OF NIGELLA SATIVA SEED EXTRACT BY AMES AND MTT ASSAY

In the modern lifestyle, people are prone to disease. The epidemiology study shows that the lung and colon cancer leading position in both the gender around the world at any group. As based on the traditional systems of medicine, the plants can be used for the discovery of new medicine. The aqueous and ethanol extract of Nigella sativa (N. sativa) seeds were evaluated for their genotoxicity using ...

B. Durga *, M. V. D. Prakash and A. Julius

Department of Biochemistry, Prince Shri Venkateshwara Arts and Science College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5760-65

5760-5765

56

34

51.

ISOLATION AND CYTOTOXIC POTENTIAL OF SILVER NANOSUSPENSION OF THE ROOTS OF APHANAMIXIS POLYSTACHYA

Objective: The study was aimed to isolate the components from the methanolic extract of the root bark of Aphanamixis polystachya and to confirm their potential cytotoxicity of the methanolic extract, silver nanoparticles and silver nanosuspension of the root bark of A. polystachya. Method: Isolation from the methanolic extract of root barks of A. polystachya were performed using column chromatogra...

R. Gude *, A. Joshi, A. Bhandarkar and D. Mayenkar

Goa College of Pharmacy, 18th June Road, Panaji, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5766-74

5766-5774

78

38

52.

TOXICITY EVALUATION AND OXYGEN CONSUMPTION STUDIES ON THE FISH CTENOPHARYNGODON IDELLA EXPOSED TO λ-CYHALOTHRIN 5% EC

The natural physiological functioning of an organism gets disturbed on exposure to toxicant stress. Toxicants affect first at cellular levels. It ultimately causes physiological, pathological, and biochemical alterations in an organism. Present study λ-Cyhalothrin of 5% EC formulation pyrethroid was used static renewal bioassay to evaluate 96 h LC50 in the freshwater fish Ctenopharyngodon idella ...

G. Rajeswari, L. Vinnakota and V. V. Rathnamma *

Department of Zoology and Aquaculture, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5775-82

5775-5782

82

37

53.

EFFECTS OF AQUEOUS FRUIT EXTRACT OF HARITAKI (TERMINALIA CHEBULA) ON REGULATION OF HYPOTHYROIDISM

The thyroid, an important part of the human endocrine system, is involved in the regulation of oxygen use, basal metabolic rate, cellular metabolism, and growth. As it acts as a regulator for the body, abnormalities of the thyroid should be reckoned with, and measures to prevent such occurrences should be followed. Hypothyroidism can be described as the inability of the thyroid gland to produce su...

B. Kumari *, T. Kumar, M. P. Sinha and M. Kumar

Department of Zoology, Ranchi University, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5783-87

5783-5787

139

41

54.

CINNAMALDEHYDE, THE MAJOR COMPONENT OF CINNAMOMUM ZEYLANICUM, AFFECTS INFLAMMATORY PATHWAYS

Cinnamaldehyde is the aldehyde that gives cinnamon its flavour and odour. It occurs naturally in the bark of cinnamon tree (Cinnamomum zeylanicum), a common Indian spice. The essential oil of cinnamon bark contains about 90% of cinnamaldehyde. It exists as a yellow oily liquid with a cinnamon odor and sweet taste and is traditionally known to have many medicinal properties, although the mechanism ...

S. Mahapatra, S. Roy, P. Chakraborty, N. Chakraborty, U. Paul, P. Chatterjee, S. Banerjee, P. Sarkar and M. Bhattacharya *

Department of Bio-Technology, Techno India University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5788-91

5788-5791

85

39

55.

DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF MANGIFERIN AND BERBERIN HCL IN BULK AND SYNTHETIC MIXTURE

Introduction: There are so many promising plant-based chemical constituents are present which act as an alternative therapy for the control of diabetes. But due to the lack of its proper quality control parameters, they are not widely used. The USFDA patent is approved for a fixed dosage combination of Mangiferin (MF) and Berberin HCl (BER) as antidiabetic herbal formulation. Objective: The litera...

B. Patel, H. Patel, M. Gohil and S. Parmar *

Department of Pharmaceutical Sciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5792-98

5792-5798

67

40

56.

DESIGN, FORMULATION AND OPTIMIZATION OF RUTIN TRIHYDRATE EMULGEL BY RESPONSE SURFACE METHODOLOGY

Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is a BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated ...

M. P. Kusuma * and C. Sushmitha

RBVRR Women’s College of Pharmacy, Affiliated to Osmania University, Barkatpura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.1111).5799-04

5799-5804

59

34

57.

PHARMACOGNOSTICAL AND PHYTOCHEMICAL STANDARDIZATION OF TUBEROUS ROOT OF SMILAX CHINA L.

In this study, the pharmacognostic and phytochemical standardization of tuberous roots of Smilax china L. belongs to the Family Liliaceae was performed in detail. Pharmacognostical standardizations like macroscopical and microscopical studies, powder microscopy, quantitative microscopy, physicochemical analysis, fluorescence study, determination of heavy metal contamination, qualitative and quanti...

B. Kumudhaveni * and R. Radha

The Tamil Nadu Dr. M. G. R Medical University, Guindy, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5805-11

5805-5811

85

44

58.

EVALUATION OF ANTIHYPERGLYCEMIC ACTIVITY OF THE POLYHERBAL AND ALLOPOLYHERBAL FORMULATION ON NICOTINAMIDE-STREPTOZOTOCIN-INDUCED TYPE-2 DIABETIC RATS

Amla, Arjuna, Gudmar, Guduchi, and Ginger have been usually used in the traditional system of medicine for the treatment of diabetes. The aim of the present study to evaluate antihyperglycemic activity of polyherbal and allopolyherbal formulation on Streptozotocin-Nicotinamide (STZ-NA) induced type-2 diabetes rats. All the extracts of herbs used for the present study were obtained by supercritical...

S. N. Belhekar *, P. D. Chaudhari and R. L. Jadhav

Department of Pharmacology, Gourishankar Institute of Pharmaceutical Education & Research, Limb, Satara, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5812-22

5812-5822

70

40

59.

LITHIUM CHLORIDE RESCUES RETINAL GANGLION CELLS IN RAT MODEL OF GLUTAMATE EXCITOTOXICITY

Retinal ganglion cell (RGC) death is distinctive of many ophthalmic disorders, such as glaucoma, optic neuropathies, and various retinovascular diseases. N-methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR)-mediated excitotoxicity is thought to be an important contributor to RGC death. Uninterrupted activation of a large number of NMDARs leads to increases in intracellular calcium loads, in...

S. Upreti, G. Yadav, M. Tiwari and P. M. Ghosh *

Amity Institute of Biotechnology, Amity University Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5823-30

5823-5830

68

47

60.

THE POTENTIAL ROLE OF NANOTECHNOLOGY TO CONTROL OF INDUSTRIAL BIOFILM

In recent years, most researchers and interesting ones in the field of microbial biofilm documented that nanoparticles like silver, metal ions play a significant role in the biofilm approach. Here i would like to draw your attention to the modern technique in biofilm and the role of nanotechnology in combating medical resistant microbial infection. It is now realized that most bacterially derived ...

C. Patel * and N. Tripathi

Department of Microbiology, Sri Satya Sai University of Technology and Medical Science (SSSUTMS), Sehore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5831-43

5831-5843

71

35

61.

ANTIMICROBIAL ACTIVITY OF FUSARIUM OXYSPORUM, ENDOPHYTIC FUNGUS, ISOLATED FROM PSIDIUM GUAJAVA L. (WHITE FRUIT)

The endophytic fungi isolated from the medicinal plant are an essential part of the current drug discovery from natural products. The endophytic fungus isolated from the healthy leaves of Psidium guajava was identified based on microscopic and cultural characteristics. The phylogenetic analysis inferred based on the internal transcribed spacer rRNA region sequence showed close similarity to Fusari...

E. C. Chutulo and R. K. Chalannavar *

Department of Applied Botany, Mangalore University, Mangalagangotri, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5844-55

5844-5855

78

39

62.

PHENOTYPIC AND MOLECULAR DETECTION OF CARBAPENEMASE NEW DELHI METALLO BETA LACTAMASE-1 (NDM-1) GENE AMONG PSEUDOMONAS AERUGINOSA FROM VARIOUS CLINICAL ISOLATES

Pseudomonas aeruginosa is an opportunistic pathogen which acquires resistance to antibiotics such as carbapenems and cefepime. Information regarding (NDM-1) gene producing Pseudomonas aeruginosa is available, but data regarding their degree of infection and percentage in hospital settings are scarce. Hence, this study was carried out to determine the occurrence of blaNDM-1 gene among clinical isol...

S. A. Siddiqui *, C. M. Noorjahan and N. Arunagirinathan

P.G. & Research Department of Zoology, Justice Basheer Ahmed Sayeed College For Women, Teynampet, University of Madras, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5856-63

5856-5863

69

40

63.

ADDUCTOR CANAL BLOCK A NEW INTERVENTION OF URVI MARMA IN AYURVEDA

Ayurveda literally meaning the ‘science of life’ believes a completely normal state of health. Marma is one of the important sciences of treatment; described in the various ancient text of Ayurveda. The life force energy i.e. Prana is concentrated at the vital points in the body known as Marma. Urvi Marma is a Vaikalyakara type of Marma situated in the lower limb in the middle of the thigh, i....

M. A. Khan * and H. H. Awasthi

Department of Rachana Sharir, Faculty of Ayurveda, Institute of Medical Sciences BHU, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5864-69

5864-5869

66

35

64.

EXPRESSION PATTERN OF BETA DEFENSIN-3 IN THE SMALL INTESTINE OF ZEBRA FISH DANIO RERIO

The vertebrate immune system is composed of numerous distinct and interdependent components, and it consists of both systemic and mucosal immune compartments, but the mucosal immune system which protects the body from the first encounter of pathogens. β-defensins are a group of cysteine-rich cationic antimicrobial peptides that play an antimicrobial roles in the immune systems of vertebrates. Ver...

R. C. Shaila *, P. Kathireswari and K. Saminathan

Department of Zoology, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5870-74

5870-5874

71

46

65.

FORCED DEGRADATION STUDY OF DARUNAVIR ETHANOLATE AND RITONAVIR COMBINATION IN ACIDIC, BASIC AND OXIDATIVE CONDITIONS ESTABLISHING DEGRADATION PRODUCTS

A simple, precise, and rapid stability indicating RP-HPLC method has been developed for the simultaneous estimation of darunavir ethanolate and Ritonavir in Pharmaceutical dosage form in the presence of degradation products. It involved the Zorbax bonus, 150 mm × 4.6 mm of 3.5 μm particles packing stationary phase. The separation was achieved using mobile phase a consists of ammonium acetate buf...

A. A. Bana, P. Patel and P. J. Mehta *

Department of Pharmaceutical Analysis, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5875-83

5875-5883

45

25

66.

A STUDY ON SERUM TOTAL BILIRUBIN AND URIC ACID IN NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS

Background: Serum total bilirubin (SBT) and serum uric acid (SUA) have anti-oxidant properties. SBT and SUA may be potential biomarkers for type 2 diabetes mellitus (T2DM) and its complications. Aim: It is aimed to evaluate the level of STB and SUA in T2DM. Materials and Methods: In this case-control study, a total of 124 subjects (62 T2DM cases and 62 age and gender-matched controls) were recruit...

M. Mishra, D. Tiwari *, M.M. Khan

Department of Biochemistry, Integral Institute of Medical Sciences and Research (IIMS&R), Integral University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5884-89

5884-5889

85

27

67.

IN-VITRO EVALUATION OF ANTI-HELICOBACTER PYLORI ACTIVITY OF COMMERCIALLY AVAILABLE PROBIOTICS

Helicobacter pylori is a major etiological agent responsible for several gastric diseases such as gastritis, peptic ulcer disease, and gastric cancer. From the last two decades, standard triple therapy is mostly recommended for H. pylori eradication; however, its efficacy is restricted by antibiotic resistance. Hence, the present study aimed at exploration for novel therapeutic agents being warran...

G. Gupta, D. Bansal, A. Sharma, T. Ahmad, A. Sachdev and B. Kaur *

Department of Biotechnology, Punjabi University, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5890-97

5890-5897

60

28

68.

PHYTOCHEMICAL EVALUATION AND DETERMINATION OF ANTIOXIDANT ACTIVITY IN DIFFERENT PARTS OF AEGLE MARMELOS

Free radicals are unstable molecules that are formed during normal cell metabolism through chemical changes that take place in a cell. This causes damage to cellular components such as cells, proteins, and DNA, or the cell membrane. Free radicals play a role in a complex interplay of different mechanisms in both normal agings, neurodegenerative, and other diseases. Aqueous and methanolic solvent ...

S. Shakyawar, S. Sundaram, E. Gupta * and S. Alok

Department of Home Science, University of Allahabad, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5898-11

5898-5911

45

29

69.

ANTIBIOTICS SUSCEPTIBILITY IN CHRONIC SUPPURATIVE OTITIS MEDIA (CSOM) AT THE SECONDARY CARE HOSPITAL IN NORTH INDIA

Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear cleft with a perforated tympanic membrane and draining exudate for more than 6weeks. Information about the organism responsible for COSM and their antibiotic susceptibility is important for effective treatment. Material and Methods: A prospective cross-sectional study was conducted on 85 pati...

A. K. Singh, S. Alok and A. Verma *

Bioorganic & Medicinal Chemistry Research Laboratory Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5912-17

5912-5917

51

35

70.

SOCIO DEMOGRAPHIC CHARACTERISTICS OF LUNG CANCER PATIENTS IN NORTH MALABAR REGION OF KERALA, SOUTH INDIA

Background: Lung cancer is the most common malignant neoplasm worldwide, accounting for greater mortality than due to any other cancer. It accounts for about 13% of all new cancer cases and 19% of cancer-related deaths worldwide. In India, lung cancer comprises 6.9% of all new cases of cancer and 9.3% of all cancer-related mortality in both sexes. This study aimed to find out the socio-demographic...

C. Muhas *, P. P. Naseef and K. M. Saheer

Department of Pharmacy Practice, KTN College of Pharmacy, Chalavara, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(11).5918-22

5918-5922

57

25

71.

IN-VITRO INSIGHT INTO THE IMPACT OF DIABETES AND IMPLANT DEBRIS ON ORTHOPEDIC IMPLANT

Wear particle evoked lysis limits the long-run survivorship of total joint replacement (TJR) in polygenic disease. Monocyte / macrophages area the key cells of this adverse reaction. The aim of this study was to come up with useful human osteoclasts (OCs) in-vitro from sort a pair of diabetes (T2D) and health management to research the potential osteoclastogenic role of T2D and implant detritus in...

A. Thenmozhi *, S. Shila, K. Nagalakshmi and P. Rasappan

Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5923-31

5923-5931

52

32