Volume 12 (2021) - Issue 11, November
Review Articles
GREEN NANOTECHNOLOGY AND NANOPARTICLES: AN ECO-FRIENDLY APPROACH
The field of nanotechnology is one of the notable active analysis areas in modern material science. Recent advances in Nanoscience and nanotechnology have led to the development of nanoparticles, which ultimately decrease potential health and environment hazards. Interest in developing environmentally friendly procedures for the synthesis of metallic nanoparticles has been increased. The purpose...
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PHYTOSOMES: A NEW VESICULAR DELIVERY FOR HERBAL MEDICINE
Phytoconstituents like flavonoids, tannins, glycosides, alkaloids and terpenoids have medicinal values. In recent years herbal medicines are developed and used to treat almost all diseases with lesser or no side effects. But the plant constituents having low half-life, poor bioavailability and stability problems because of their high particle size and high aqueous solubility. Phytosomes are the ca...
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CURRENT SCENARIOS ON REGULATORY LANDSCAPE OF INDIAN PHARMACEUTICAL INDUSTRIES
India is the fourth largest generic pharmaceutical market in the world. Indian pharmaceutical industries are very well established in today’s world and continuously producing a variety of products, which are useful in the treatment of various diseases and grabbing the market segments. India has a large number of resources to contribute vitality in the research and manufacturing process, and due ...
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ORAL CANCER AND ITS EPIDEMIOLOGY, THERAPY AND RISK FACTORS, CASE STUDIES IN KARNATAKA: A REVIEW
Oral cancer is one of the lethal cancers, having first rank in India and sixth most deadly cancer in world and most of the time occurs due to improper lifestyle and adverse habits. Cancers of the lung, oral cavity, pharynx, larynx, esophagus, urinary bladder, renal, pelvic and pancreas are among the neoplastic diseases induced by smoking. Epidemiological studies have firmly identified the connecti...
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AN OVERVIEW OF AETIOPATHOGENESIS AND PREVENTION OF INFECTIOUS CANCERS
Currently, the knowledge on the oncogenic behaviour exhibited by microbial agents is the result of long and laborious studies conducted over the years. It started with the liver fluke infection associated with bile duct carcinoma and bilharziasis with bladder cancer. Following this, multiple pathogens got implicated in carcinogenesis, including bacteria, many viruses, and even fungi. For some of t...
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MUSHROOM SECONDARY METABOLITES: CHEMISTRY AND THERAPEUTIC APPLICATIONS
Since ancient times, humans have always been captivated by nature and have explored natural products. To combat against novel emerging and reemerging diseases and tremendous side effects imposed by recent therapies, scientists have again taken an interest in natural resources. To date, plants have been the major source of natural bioactive compounds, but recently fungi have got more attention. Amo...
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ETHNOBOTANICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL SCIENCE OF TRACHYSPERMUM AMMI (AJWAIN) A SYSTEMATIC REVIEW
The aim of the present investigation was a systemic review of Trachyspermum ammi L. (Ajwain) coming from the family Apiaceae and its medicinal significance. The seeds of ajwain include approximate three-5% crucial brownish oil, and this species additionally incorporate thymol as the principal chemical constituent at the side of a few different important constituents like β-pinene, α-terpinene, Î...
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A COMPREHENSIVE REVIEW OF THE TRADITIONAL AND PHYTOPHARMACOLOGICAL USES OF ROSA DAMASCENA MILL.
Mother nature has gifted with many herbs that have been found to have various pharmacological and therapeutic activities. One among them is the Rose plant which is available everywhere easily and has been used for ages. There are at least 200 species of rose flowers, amongst them Rosa damascena Mill. species is widely utilized in many industries for different purposes. Rosa damascena well-known as...
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PERIPHERAL NEUROPATHY-THE LEADING CAUSE FOR GENERAL WEAKNESS
Peripheral neuropathy refers to many conditions that involve damage to the peripheral nervous system. In this article, we would like to discuss various aetiological factors and their manifestations, pathophysiology, diagnosis and treatment strategies of peripheral neuropathy. Generally, peripheral neuropathy is caused by many underlying disease conditions such as Diabetes mellitus, Shingles (posth...
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Research Articles
ABELMOSCHUS ESCULENTUS L. MITIGATES NAFLD PATHOLOGIC PHENOTYPES IN C57BL/6J MOUSE MODEL
Purpose: Lifestyle modification is recommended as a primary strategy for the management of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Recently, metabolic regulations of diets containing parts of Abelmoschus esculentus (okra) were investigated using the NAFLD mouse model. Methods: Five groups of C57BL/6J mice (n = 6) were arranged. Each received a distinct d...
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OPTIMIZATION, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITY OF BERBERINE LOADED NANOPARTICLES – AN APPROACH TO IMPROVE THE EFFICACY OF ANTICONVULSANT AND ANTIOXIDANT ACTIVITY
Berberine, an isoquinoline alkaloid that has better anticonvulsant and antioxidant activities, results in less efficacy due to poor solubility, poor permeability, poor stability and poor drug delivery to the brain. Hence, this study aim at improving Anticonvulsant and Antioxidant activities of Berberine by formulating nanoparticles with three-factor two-level boxbehnken with design expert software...
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EFFECT OF MORINGA OLEIFERA LAM. ROOT ON COLONIC MOTILITY DISORDERS INDUCED BY WATER AVOIDANCE STRESS IN RATS
Irritable bowel syndrome (IBS) is a chronic condition that affects the lower gastrointestinal tract. It affects the function and behavior of the intestine resulting in abdominal pain, flatulence, loose stools, frequent stools, feeling of being unable to completely empty bowel and nausea. Moringa oleifera, also commonly known as drumstick tree, is a highly valued plant with a wide range of medicina...
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IN-VITRO ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF THE COMBINED S-ALLYL CYSTEINE AND TAURINE
Diabetes mellitus is one of the familiar metabolic disorders affecting the global population. In the modern system of medicine, there are still no satisfactory promising agents available for the effective management and treatment of diabetes. The current study aimed to investigate the in-vitro antioxidant and antidiabetic potential of the combination of s-allyl cysteine (a phytochemical) and tauri...
988
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DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF SUSTAINED FLOATING HOLLOW MICROSPHERES CONTAINING LABETALOL HCL FOR THE TREATMENT OF HYPERTENSION
Aim: The present work for the development and in-vitro evaluation of sustained floating hollow microspheres (SFHM). Materials and methods: Sustained floating hollow microspheres were prepared by means of HPMC K4M, ethylcellulose and sodium alginate in various concentrations by using the solvent evaporation method using dichloromethane as solvent. The floating hollow microspheres of Labetalol HCl w...
970
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IN-VITRO COMPARATIVE QUALITY ASSESSMENT OF DIFFERENT BRANDS OF DICLOFENAC SUPPOSITORIES AVAILABLE IN THE KUMASI METROPOLIS, GHANA
Drugs play a vital role in maintaining and promoting health. The safety, efficacy, and quality of the drugs must be assessed to protect the health of the user. Diclofenac is a cyclooxygenase inhibitor and one of the most useful, effective commercially available NSAIDs used in the management of pain. Many different brands and dosage forms (tablets, oral powder, and suppositories) of diclofenac are ...
758
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NEW CO-PROCESSED EXCIPIENTS WITH MICROCRYSTALLINE CELLULOSE AND ISOMALT BY FLUID BED. AN OPTION FOR DIRECT COMPRESSION EXCIPIENTS
Objective: To elaborate and characterize new co-processed excipients for direct compression use. Methods: The new co-processed excipients were obtained with different proportions of microcrystalline cellulose (Avicel® PH101) and Isomalt (galenIQ® 800), using Starch® 1500 and Plasdone® K-25as binding agents in a fluid bed. Rheological characterization was performed; to determine their deformati...
743
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FORMULATION AND EVALUATION OF SOLID-SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF FAMOTIDINE
The main objective of the study was to formulate and evaluate solid self nano emulsifying drug delivery systems (SNEDDS) of famotidine (BCS class-IV drug), a histamine receptor antagonist used in case of ulcers, Zollinger-ellison syndrome. Liquid SNEDDS was formulated using oils like oleic acid, arachis oil, surfactants like Tween 20, Tween 80, etc., and co-surfactants like Transcutol-P, polyethyl...
725
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AMELIORATIVE POTENTIAL OF BETULINIC ACID AND ROTUNDIC ACID ON NEPHROTOXICITY INDUCED BY MERCURY CHLORIDE IN RATS
Mercury toxicity is the most hazardous problem emerging in the world as its accumulation is escalating persistently through the increased utility of mercury in medicinal, industrial, and domiciliary usage. Subjection to mercury illustrates a consequential provocation to humans and other living biomes. The intention of the present research was to investigate the shielding potential of betulinic aci...
679
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FORMULATION AND EVALUATION OF CLOPIDOGREL BISULFATE CAPSULE LOADED NANOPARTICLES
The present study aims to formulate and evaluate clopidogrel bisulfate capsule-loaded nanoparticles. Clopidogrel bisulfate nanoparticles were produced by the nano-precipitation method and emulsification solvent evaporation method using ethylcellulose polymer at different ratios and characterized for particle size drug entrapment efficiency dissolution testing scanning electron microscopy imaging (...
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PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL ACTIVITY OF DIFFERENT CITRUS FRUIT PEELS
Citrus fruit is a very rich source of Vitamin C, A, E, and flavonoids, alkaloids, and minerals. Citrus fruits are medicinal plants that present rutaceae family and include some fruits such as orange (Citrus sinensis), kinnow (Citrus reticulata), mosambi (Citrua ltmetta), grapefruit (Citrus maxima) lime, pomelo lemon. Antibacterial antiviral, antifungal activity of different solvent extracts (Ace...
2245
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DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS AND STABILITY STUDIES OF RANOLAZINE IN BULK AND DOSAGE FORMS
Objectives: The present study aimed to develop simple and accurate first and second-order derivative spectrophotometric methods (1D and 2D) for the assay and stability studies of Ranolazine (RAN) in bulk and dosage forms. Methods: The original UV spectrum of RAN solution in methanol was differentiated instrumentally to generate the first and second derivative spectra which were measured at 278 nm ...
709
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FORMULATION AND EVALUATION OF SUSTAINED-RELEASE TABLET OF TRAZODONE HYDROCHLORIDE
The main objective of this study was to formulate a Sustained release tablet by wet granulation method. A sustained release tablet of trazadone hydrochloride was prepared by using synthetic polymer. The prepared tablets were evaluated for their diameter, thickness, drug content, Hardness, friability, weight variation. The thickness and diameter of the tablet range from 5.43±0.288 to 5.76±0.05 an...
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PHARMACOGNOSTIC EVALUATION OF LAGERSTROEMIA SPECIOSA FRUIT
Lagerstroemia speciosa (Lythraceae), commonly known as Banaba which bears attractive and colourful pink or purple flowers. The leaf of the plant is used as a remedy for the treatment of diabetes. The seed, root, stem bark of the plant has shown a promising pharmacological effect. Fruits are used for diarrhoea, mouth ulcers. Pharmacognostic evaluation of leaves stems and stem bark is available in t...
850
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EXPLORING SOME ANTIMALARIAL PLANTS SOLD IN THE MARKET IN LIBREVILLE GABON
The increasing microorganism resistance to common antimicrobial drugs constitutes a major public health issue worldwide and particularly in Gabon. The objective of this study was to conduct an ethnobotanical survey among merchants of Peyrie market in Libreville (Gabon) to identify plants or a combination of plants used to treat malaria in traditional medicine. Information was collected by intervi...
714
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HPTLC METHOD DEVELOPMENT AND VALIDATION FOR THE IN-VITRO INTERACTION STUDY OF MEBENDAZOLE WITH ATORVASTATIN
By HPTLC method, a mobile phase system comprising of Ethyl acetate: Toluene: Methanol (5:4:1v/v/v) was selected, and the detection was carried out at 280nm. The Rf values were found to be 0.65 ± 0.03 and 0.27 ±0.03 for Mebendazole and Atorvastatin, respectively, which showed a good separation. The method was validated as per ICH guidelines. The percentage RSD values of repeatability, intraday, a...
651
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IN-VITRO DRUG RELEASE KINETICS FROM CONTROLLED-RELEASE GLIPIZIDE MATRIX TABLETS AND THE INFLUENCE OF TWO DIFFERENT DILUENTS ON DRUG RELEASE PATTERNS
The objective of the study was to formulate and evaluate controlled release glipizide matrix tablets for the release rate, release patterns, and the mechanism involved in the release process of the drug. Formulations with hydrophobic and hydrophilic polymer in several drug-to-polymer ratios and using water-soluble and water-insoluble diluents were compressed into tablets using the direct compressi...
736
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LCMS/MS QUANTITATION OF CATECHOLAMINES AND THEIR PREDECESSORS FROM PORTULACA OLERACEA AND GOMPHRENA GLOBOSA
The plants Portulaca oleracea and Gomphrena globosa belong to the order Caryophyllales, and their flowers are known to produce betalains. The biosynthesis of betalains involves various intermediate molecules such as catecholamines or biogenic amines. Catecholamines include dopamine, adrena-line (epinephrine), and noradrenaline (norepinephrine) and are normally believed to be released in response t...
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EVALUATION OF DETRIMENTAL FACTORS OF DRINKING WATER AND THE EFFECT OF BLOOD GLUCOSE LEVELS AND ANXIETY STATUS: AN EXPERIMENTAL STUDY IN WISTAR ALBINO RATS USING ELEVATED PLUS MAZE
This study is focused on evaluating the detrimental factors of drinking water and its relation to blood glucose level and anxiety status of non-stressed experimental rats. The study was conducted on 30 adult Wistar albino rats. The control group was treated with filtered water by reverse osmosis unit, and test 1, test 2, test 3, and test 4 groups were treated with well water from rural area 1, r...
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ENHANCEMENT OF BIOACTIVE CRUDE COMPOUND PRODUCTION BY STATISTICAL OPTIMIZATION OF FERMENTATION PARAMETERS FROM STREPTOMYCES SP. NLKPB45 ISOLATED FROM MARINE SOIL SEDIMENT
Actino bacterium Streptomyces sp. NLKPB45, which was isolated from mangrove soil sediments of Nellore coastal regions of Andhra Pradesh, India, was used in shake-flask fermentation to explore the different carbon and nitrogen substrates for antimicrobial crude compound. Careful experimentation of ranging each variable in the fermentation medium found that glucose and peptone as preferred carbon an...
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PHARMACOPHORE BASED MODELLING OF PYRIDINE-PYRIMIDINE ANALOGS AS MER TYROSINE KINASES INHIBITORS IN ANTICANCER THERAPY
MER kinase is an important tyrosine-kinase receptor that is associated with a variety of cancers, including mantle cell lymphomas, pituitary adenomas and T-cell acute lymphoblastic leukemia. Identification of new MERTK inhibitors assumes crucial importance. Only one ligand-based pharmacophore model is reported to date for MERTK inhibitors. There are many more molecules with improved enzyme inhibit...
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FORMULATION AND EVALUATION OF PROPRANOLOL HYDROCHLORIDE ORAL DISINTEGRATING TABLETS
Background and purpose of the study: Propranolol hydro-chloride beta-adrenergic receptor antagonist utilized in the treatment of high blood pressure, atrial fibrillation, myocardial infarction, angina and migraine headaches. The pharmacokinetic parameters make Propranolol hydrochloride an appropriate candidate for oral disintegrating tablets. This work aims to develop orally disintegrating tablets...
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STUDIES ON ANTIMICROBIAL ACTIVITY OF HIBISCUS SPECIES OF KARNATAKA AGAINST CLINICAL ISOLATES
Antimicrobial activity of the various species of Hibiscus like Hibiscus sabdariff, Hibiscus rosa-sinensis, Hibiscus trionum, Hibiscus cannabinus, Hibiscus mutabilis against various pathogens like Staphylococcus aureus, E. coli, Bacillus subtilis, Streptococcus species, Salmonella typhimurium, Klebsiella pneumonia, Pseudomonas aeruginosa, Serratia marcescens, were studied with the help of agar well...
732
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AN OPTIMIZED HERBAL FORMULA DIMINISHES CCL4-INDUCED HEPATOTOXICITY IN RATS BY INHIBITION OF LIPID PEROXIDATION AND P53-MEDIATED APOPTOSIS
Introduction: In this present study, the heaptoprotective effect of an optimized herbal formula (HF) was evaluated against carbon tetrachloride (CCl4)-induced liver injuries in rats. Methods: In-vitro antioxidant activity of the HF was evaluated by reducing power, lipid peroxidation, and DPPH scavenging assays. Hepatoprotective activity of HF (100, 200 and 400 mg/kg b.w) was evaluated against CCl4...
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A SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR IMPROVEMENT IN ORAL BIOAVAILABILITY OF NIMODIPINE: IN-VIVO EVALUATION
The current research involves the study of a Nimodipine self-nanoemulsifying drug delivery system (SNEDDS) with improved bioavailability and solubility. Fifteen formulations of Nimodipine SNEDDS were prepared prior to evaluation of particle size, emulsification time, percentage drug release, percentage transmittance, thermodynamic stability and in-vitro drug release. The formulation F13 was chosen...
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FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN FOR SOLUBILITY ENHANCEMENT BY QUALITY BY DESIGN APPROACH
Rosuvastatin is an antihyperlipidemic agent belonging to BCS class II Drugs with low aqueous solubility and high permeability. Objective: To formulate Rosuvastatin nanosuspension by Emulsification solvent diffusion technique by QbD approach and its evaluation. A 2² factorial design was employed to study the effect of independent variables [SLS (X1) and amount of PVP K -30(X2)] and dependent varia...
2019
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QUANTITATIVE AND QUALITATIVE PHYTOCHEMICAL ANALYSIS IN BARK OF NOTHOPEGIA RACEMOSA (DALZ.) RAMAM. COLLECTED FROM GADIKALLU, SHIMOGGA, KARNATAKA
Plants are a source of bioactive compounds produced by different parts of the plant, maybe bark, leaves, flowers, roots, fruits, and seeds, during metabolic activities. These secondary metabolites may have protective and disease preventive properties, hence used by Traditional practioner to treat various ailments. Most plants of the Western Ghats of India remain unknown, poorly understood or unest...
709
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EFFICACY OF DRUGS IN DRUG-RESISTANT TUBERCULOSIS: A RETROSPECTIVE OBSERVATIONAL STUDY
Introduction: Drug-resistant tuberculosis (DR-TB) emerged from the time anti-tuberculosis drugs were discovered and used. It has become a formidable obstacle in the eradication of tuberculosis. India is in second position after China with tuberculosis, where about 20% of patients with DR-TB were not treated due to inappropriate coordination and diagnostic facilities. Method and Materials: A retros...
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THE AFRICAN BAOBAB SEED OIL AND ITS POTENTIAL FOR SOLUBILISING POORLY SOLUBLE DRUGS
Most lipids used in solubilizing poorly soluble drugs are synthetic or semi-synthetic. In this study, the African Baobab seed oil (natural oil) was investigated for its potential in solubilizing poorly soluble drugs in a microemulsion formulation. Oil was extracted from untreated seeds by hydraulic pressing. Physicochemical characteristics of the oil were determined. The solubility of Furosemide, ...
879
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DEVELOPMENT AND VALIDATION OF TLC-DENSITOMETRIC METHOD FOR ESTIMATION OF FLUPIRTINE MALEATE AND ITS FORMULATIONS
A simple, precise, accurate, and reliable high-performance thin-layer chromatographic method has been developed and validated for the analysis of flupirtine maleate in capsule dosage form. Identification and analysis were performed on 10 cm × 10 cm layer thickness 0.2 mm, precoated silica gel G60-F254 aluminum sheet, prewashed with methanol, and dried in an oven at 50 °C for 5 min. Ethyl acetate...
639
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SYNTHESIS, SPECTROSCOPIC INVESTIGATION AND BIOEFFICACY OF SOME NOVEL SCHIFF BASE METAL (II) COMPLEXES
Two monobasic bidentate ligands L1H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazine-carboxamide] and L2H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarbothioamide] were synthesized by the condensation of [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene) with semicarbazide and thiosemcarbazide, which formed a series of complexes with cobalt(II) and nickel(II). The ligands ...
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AN HPLC WITH PHOTODIODE ARRAY DETECTION METHOD FOR SIMULTANEOUS DETERMINATION OF ENROFLOXACIN AND ITS ACTIVE METABOLITE, CIPROFLOXACIN, IN CHICKEN MEAT
A reverse-phase liquid chromatography (LC) method was developed for the simultaneous estimation of enrofloxacin and its active metabolite ciprofloxacin residues in chicken meat. These two fluoroquinolones were extracted from homogenized tissues with phosphate buffer under acidic conditions, followed by acetonitrile. The isocratic LC analysis was performed on Phenonmenax, C18 RP column (250 × 4.6 ...
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EFFECT OF HELLENIA SPECIOSA (J. KOENIG) S. R. DUTTA ON HEMATOLOGICAL INDICES OF ALLOXAN INDUCED DIABETIC RATS
The present study aimed to evaluate the effect of crude leaf extract of Hellenia speciosa on hematological parameters of alloxan-induced diabetic rats. The study was carried out using alloxan model of diabetes for a period of 28 days and at the end of the treatment rats were sacrificed and blood samples were collected for the estimation of hematological parameters. The results showed that the whit...
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A VALIDATED STABILITY-INDICATING RP-HPLC METHOD FOR DETERMINATION OF ESMOLOL HYDROCHLORIDE AND ITS RELATED IMPURITIES
Esmolol Hydrochloride belongs to the class II anti-arrhythmic drugs. Due to composite compositions and low reproducibility, challenges are still warranted for the systematic method development for related substances and identification of its acid degradation products. Development, validation and characterization of RP-HPLC stability-indicating method for the quantitative analysis of two impurities...
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DEVELOPMENT AND VALIDATION OF SPECTROSCOPIC METHODS FOR THE SIMULTANEOUS ESTIMATION OF RASAGILINE AND RILUZOLE
In the present study, an effort has been made to estimate Rasagiline and Riluzole simultaneously in their bulk and physical mixture by UV-Visible spectrophotometric methods. The methods developed are precise, reliable simultaneous equations and area under the curve (AUC) method. The absorption maxima in the simultaneous equation method are 265.20 nm and 263.40 nm, respectively, for rasagiline and ...
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ISOLATION, PURIFICATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM STACHYTARPHETA URTICIFOLIA (SALISB.) SIMS
Natural products from various medicinal plants, in the form of pure compounds or standardized extracts, which provide unlimited opportunities for discovery of new drug leads, is due to the unmatched availability of chemical diversity. There is an increasing demand for chemical diversity in screening programs, seeking therapeutic drugs from natural products, interest, particularly in edible plants,...
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TO EVALUATE THE CHEMICAL CONSTITUENTS OF SHODITHA (PURIFIED) AND ASHODHITHA (RAW) DATURA METEL LINN ROOT – A ANALYTICAL STUDY
Datura (Datura metel Linn.) is a herbaceous leafy annual and short-lived plant of the Solanaceae family. It's commonly known as Angel's trumpet, Devils apple, Jimson weed, stinkweed, and Thorn apple. The traditional system of medicine enlightened the importance of Datura metel Linn. of its great medicinal value. The roots, leaves and flowering tops have been used in India for their narcotic and an...
672
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ANTIOXIDANT, ANTI-ANGIOGENIC AND CYTOTOXIC EFFECT OF ALOE BARBADENSIS, A MEDICINAL PLANT FROM INDIA
Background: Aloe barbadensis (AB) is a member of the Liliaceae family, traditionally used for thousands of years in some parts of India and well known for its anti-inflammatory, antimicrobial, and wound healing properties. The purpose of the study is to evaluate the antioxidant, anti-angiogenic and antiproliferative effect of AB methanolic root extract on A549 lung cancer cell line. Methods: The A...
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SPECTRAL ANALYSIS OF METHANOLIC ROOT BARK EXTRACT OF SEMAL (BOMBAX CEIBA) USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY
Bombax ceiba L. is an important medicinal plant belonging to the family Bombacaceae. Root bark samples of the plant have been subjected to phytochemical investigation through gas chromatography-mass spectrometry (GC-MS). Twenty phytochemical compounds have been identified in the methanolic extract of B. ceiba root bark. The identification of phytochemical compounds is based on the peak area, reten...
679
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DRUG UTILIZATION TRENDS OF ORAL ANTI-DIABETIC AGENTS AMONG DIABETES MELLITUS TYPE 2 PATIENTS IN A TERTIARY CARE HOSPITAL
Diabetes is a group of metabolic diseases and emerged as a major healthcare problem. According to the International Diabetes Federation (IDF), India has a large number of people suffering from diabetes, which will increase to almost 101 million by the year 2030. The pharmacotherapies of diabetes mellitus are diversified in their mechanism of action, safety profiles and tolerability. Drug utilizati...
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A NEW ASSAY METHOD DEVELOPMENT AND VALIDATION OF TWO ANTI-CANCER DRUGS BY USING EFFECTIVE LIQUID CHROMATOGRAPHIC METHOD
A simple, sensitive and rapid chromatographic method was developed and validated for quantification of Mitomycin and Fluorouracil in bulk and pharmaceutical dosage form using Symmetry C18 (4.6 × 150 mm, 3.5 µ) column. The mobile phase consists of buffer, 0.1% Ortho Phosphoric acid (OPA), and acetonitrile in the ratio of 50:50 v/v. The flow rate is maintained as at 1.0 ml/min; detection was carri...
673
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UTILIZATION OF GLUTEN-FREE COMPOSITE FLOUR NUTRITIONAL, PHYTO-CHEMICAL AND FUNCTIONAL PROPERTIES EVALUATION
Celiac disease an antibody-mediated enteropathy which is a lifelong condition where there is intolerance towards gluten. The only treatment till now is the gluten-free diet. The aim of this study was to investigate proximate, phytochemical and functional property analysis of gluten-free composite flour. The proximate analysis of composite flour for the most acceptable sample showed moisture (10.97...
699
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DEVELOPMENT AND IN-VITRO EVALUATION OF CENTELLA ASIATICA AND SILVER SOLUTION COATED SUTURES FOR ANTIBACTERIAL ACTIVITY
The research aim is to develop and evaluate Centella asiatica Chloroform extract and silver-coated suture against the most common organisms that cause surgical site infections (SSI) by in-vitro methods. This prospective study is to coat the Centella asiatica (CA) extract to the suture along with the silver nitrate solution. In this study, a suture filament was formulated with Poly Lactic Glycolic ...
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ISOLATION AND CHARACTERISATION OF L-GLUTAMINASE PRODUCING FUNGI FROM MARINE SOURCE
L-glutaminase [EC.3.5.1.2] is an amidohydrolase that catalyzes the hydrolytic deamination of L-glutamine, resulting in the production of L-glutamic acid and ammonia. The L-glutaminase has received a significant attention due to its potential as an anticancer agent. In the present study, soil sediments were collected from the estuaries region of Parangipettai, Cuddallore District, Tamil Nadu. The i...
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A NEW DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF ANTI-RETROVIRAL DRUGS IN PHARMA-CEUTICAL DOSAGE FORM
In this study, a new simple, rapid and accurate, sensitive isocratic method was developed for the simultaneous determination of the Anti-retroviral drugs in pharmaceutical dosage forms. The chromatography was run through Denali C18 column (150 x 4.6 mm and 5 µm particle size). Mobile phase containing mixer of buffer 0.1% OPA (PH.4.6) acetonitrile is taken in the ratio 40:60 was pumped through col...
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