Pages Menu
TwitterRssFacebook
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

Categories Menu

Volume 3 (2012) - Issue 2, February

Review Articles

 
Title
Views
PDF
Cited
1.

A REVIEW ON DIABETIC NEUROPATHY AND NEPHROPATHY

Diabetes is a major public health problem. Diabetes mellitus now affects large number of people in many developing countries than western countries where only two or three percent of the population is affected. With on estimated 33 million people in India alone affected by diabetes. It is a major epidemic of the twentieth century. Diabetes is a chronic disorder, which is associated with obesity, h...

Mohd. Muneer Ahamed* and Otilia Banji

Department of Pharmacology, Nalanda College of Pharmacy, Nalgonda- 508 001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).300-304

300-304

2961

585

2.

PHARMACOLOGICAL POTENTIALS OF MORINGA OLEIFERA LAM.: A REVIEW

The aim of this literature review was to provide advance research information for the future scientists to discover new drug molecules from the medicinal plant, Moringa oleifera Lam. (Moringaceae). The plant provides a rich and rare combination of zeatin, quercetin, beta-sitosterol and kaempferol. In addition to its high nutritional value, Moringa oleifera Lam is very important for its medicina...

Subrata Kumar Biswas*, Anusua Chowdhury, Joysree Das , Ajoy Roy and S.M Zahid Hosen

Assistant Professor, Department of Pharmacy (BGC Biddyanagar), BGC Trust University Bangladesh, BGC Tower (Fazal Tower), 1675 O.R. Nizam Road, Chittagong-4000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).305-10

305-310

3154

2207

3.

SOFT AND DISSOCIATIVE STEROIDS: A NEW APPROACH FOR THE TREATMENT OF INFLAMMATORY AIRWAY AND EYE DISEASES

Glucocorticosteroids (GCs) are commonly used for long-term medication in immunosuppressive and anti-inflammatory therapy, but prolonged use of GCs produce number of systemic side effects.  To further improve the therapeutic index, that is the ratio of the toxic to the therapeutic dose of a drug, it is at least theoretically possible by changing both pharmacokinetics and pharmacodynamic parameters...

Nirav P. Chandegara* and Mehul R. Chorawala

Department of Pharmacology, K. B. Institute of Pharmaceutical Education and Research, Gh-6, Sector-23, Gandhinagar-382023, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).311-19

311-319

3001

558

4.

POSTMENOPAUSAL OSTEOPOROSIS- AN UPDATED REVIEW

Osteoporosis is a major growing public health problem with impact that crosses medical, social, and economic lines. Osteoporosis in older women is the 2nd most cause of death in America thus it is one of the essential area to be understand in medical science and need to update time to time. The objective of the present review is to update all aspect of osteoporosis in postmenopausal women, includi...

A. Suhas*, T. Satyavaishnavi, T. Sana, K. Zansi, K. Sushma and S. Aditya

Nalanda College of Pharmacy, Charlapally, Department of Pharmacology, Nalgonda-501008, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).320-28

320-328

1299

553

5.

CARBON NANOTUBES: AN APPROACH TO NOVEL DRUG DELIVERY SYSTEM

Carbon nanotubes are cylindrical carbon molecules have novel properties, making them potentially useful in many applications in nanotechnology, electronics, optics, and other fields of material science as well as potential uses in architectural fields. They have unique electronic, mechanical, optical and chemical properties that make them good candidates for a wide variety of applications, includi...

M. H. Alai*, S. P. Poptani and G.V. Patil

Radhai Niwas, Behind bus stand, A/P- Nampur, Tal- Satana, Dist- Nasik- 423204, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).329-39

329-339

1493

432

6.

REGULATORY CHALLENGES IN GLOBAL PHARMACEUTICAL MARKET

The global pharmaceutical industry “looks like the epitome of a modern, mature industry that has found a comfortable way to make profits by the billion: it’s global, hi-tech, and has the ultimate customer, the health care budget of the world’s richest countries. A number of factors contributed to the globalization of the pharmaceutical industry. Chief among these are the convergence of medic...

Vibhu Yadav* and Deepak Kaushik

M. Pharmacy (Drug Regulatory Affairs), Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).340-45

340-345

4431

602

7.

VINPOCETINE: A SMART DRUG AND A SMART NUTRIENT: A REVIEW

Vinpocetine, a semisynthetic derivative alkaloid of Vincamine, an extract from the periwinkle (plant) Vinca minor is the first full-fledged nootropic (a supplement positively affecting the mind). Vinpocetine is safe and non-toxic with an amazing array of functional and structural benefits for improved health. Vinpocetine appears to improve a person's ability to acquire new memories and to restore ...

M.K. Jha*, M.H. Rahman and Hasib Sheikh

B. Pharm (Hon’s), MS Pharm. Tech. Lecturer, Department of Pharmacy, School of Health and Allied Sciences, Pokhara University, Lekhnath-12, Kaski, Nepal

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).346-52

346-352

3119

1389

8.

WARFARIN RESISTANCE-MECHANISMS AND MANAGEMENT

Anticoagulants are a class of drugs commonly used to prevent the blood from forming dangerous clots that could result in a stroke.Warfarin is an oral anticoagulant. Warfarin differs from most other drugs in that the dosage required to achieve a desired therapeutic effect varies greatly among individuals. Resistance to warfarin has been described as the inability to prolong the prothrombin time or ...

R. Lakshmi*, S. Anitha, K. N. Anila, P. R. Roshni

Department of Pharmacy Practice, Amrita School of Pharmacy, AIMS Health Care Campus, Ponekkara PO, Kochi, Kerala- 682 041, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).353-57

353-357

5493

2422

9.

CURRENT TRENDS IN PULSATILE DRUG DELIVERY SYSTEMS

The purpose for this review on pulsatile drug delivery systems (PDDS) is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation. Pulsatile drug delivery system is the most interesting time and site-specific system. This system is designed for chronopharmacotherapy. Thus, to mimic the function of living systems and i...

S. R. Tajane*, B. B. Kholwal, S. S. Suryawanshi and K. N. Tarkase

Department of Quality Assurance Techniques, P.D.V.V.P.F’S College of Pharmacy, MIDC, Vilad Ghat, Dist. Ahmednagar, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).358-66

358-366

1827

570

10.

DEVELOPMENT AND CHRACTERIZATION OF SELF ASSEMBELED NANOPARTICLES: A REVIEW

Various types of lipid based vesicular systems have been developed in controlled and targeted drug delivery. Self assembled nanoparticles (SAN) has advantages over traditional colloidal vesicular systems and also avoids some of their major disadvantages. SAN made of solid lipids are submicron colloidal carriers (50-1000nm). These consist of a solid hydrophobic core having a monolayer of phospholip...

Shipra Duggal* and Kapil Kanwar

C.T. Institute of Pharmaceutical Sciences, Shahpur, Jalandhar, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).367-75

367-375

1368

737

11.

TRANSDERMAL DRUG DELIVERY SYSTEM: REVIEW

Transdermal drug delivery system (TDDS) are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. It works very simply in which drug is applied inside the patch and it is worn on skin for long period of time. By this constant concentration of drug remain in blood for long time. Polymer matrix, drug, permeation enha...

Virendra Yadav

Department of Pharmaceutics, Manav Bharti University, Solan, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).376-82

376-382

2707

1057

12.

RESEALED ERYTHROCYTES AS A POTENTIAL DRUG CARRIER SYSTEM

Novel drug delivery system has been introduced to overwhelm the drawback of fluctuating drug levels associated with conventional dosage forms. Out of various cellular carrier systems, erythrocytes (red blood cells, RBC) have been the most widely investigated and found to possess great potential for the delivery of drugs and drug-loaded microspheres. These cellular carriers, having remarkable bioco...

Reena Gill

SBMN Institute of Pharmaceutical Science and Research, Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).383-97

383-397

1396

481

13.

PHARMACOGNOSTICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON CLITORIA TERNATEA FOR ANTIASTHMATIC ACTIVITY

In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Use of plant based drugs and chemicals for curing various ailments and personal adornment is as old as human civilization Clitoria ternatea is used for curing various diseases and symptoms. Clitoria t...

Neelmani Chauhan*, Sourabh Rajvaidhya and B. K. Dubey

Department of Pharmacognosy, T.I.T. College of Pharmacy, Anand Nagar, Bhopal- 462 021, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).398-04

398-404

2960

1750

Research Articles

 
Title
Views
PDF
Cited
14.

PROTECTIVE ROLE OF NANOCONJUGATED VANCOMYCIN AGAINST VANCOMYCIN SENSITIVE STAPHYLOCOCCUS AUREUS INDUCED OXIDATIVE STRESS AND DNA DAMAGE

Staphylococcus aureus causes a wide range of infection such as skin and soft tissue infection to life threatening disease like respiratory tract infection, musculoskeletal infection, endocarditis and urinary tract infection. The aim of the present study was to evaluate the possible protective effects of nanoconjugated vancomycin against VSSA infection on select makers of oxidative damage and antio...

Subhankari Prasad Chakraborty , Panchanan Pramanik and Somenath Roy*

Professor, Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore -721 102, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).405-15

405-415

1276

513

15.

ANTIHYPERGLYCEMIC AND ANALGESIC ACTIVITIES OF ETHANOLIC EXTRACT OF CASSIA FISTULA (L.) STEM BARK

The present study was designed to evaluate antihyperglycemic and analgesic effects of ethanolic extract of Cassia fistula (CF) stem barks in rats and mice, respectively. The analgesic effect of extract was evaluated by acetic acid induced writhing test method while antihyperglycemic effect was investigated by oral glucose tolerance test (OGTT) in normal and alloxan induced diabetic rats. Diclofena...

M. Ashraf Ali*, Hashim Ahmad Sagar , Most. Chand Sultana Khatun , A. K. Azad , Kohinur Begum and Mir Imam Ibne Wahed

Lecturer, Department of Pharmacy, Bangladesh University, Mohammadpur, Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).416-23

416-423

1777

562

16.

PHYTOCHEMICAL SCREENING AND ESSENTIAL OIL ANALYSIS OF ONE OF THE PERSIAN SEDGES; CYPERUS ROTUNDUS L.

Phytochemical investigations of tuber extracts and evaluation of the hydro-distilled essential oil, obtained from Cyperus rotundus L. (Cyperaceae Family) growing wild in Isfahan Province (Iran) were studied. Phytochemical surveys revealed the presence of flavonoids, tannins, alkaloids and essential oils. Chemical composition of dried tubers essential oil was also analyzed by GC/MS. Sixty natural c...

Alireza Ghannadi *, Mohammad Rabbani , Lili Ghaemmaghami and Nahid Malekian

Professor, Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).424-27

424-427

1888

619

17.

IN-VITRO ANTIMICROBIAL ACTIVITY OF AEROMONAS SPP ISOLATED FROM ESTUARY USING DIFFERENT SCREENING PROTOCOLS

Screening is important in investigating antimicrobial activities of bacteria in a quest to discover new antimicrobials. Various protocols are readily available and employed by researchers worldwide studying microbiostatic and microbicidal activities of bacterial. This research therefore aims at evaluating available protocols and suggesting a standardized model. For the purpose of these research, a...

O. A. Odeyemi*, A. Ahmad and G. Usup

School of Biosciences and Biotechnology, Faculty of Science and Technology, National University of Malaysia, UKM Bangi, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).428-33

228-433

1580

1045

18.

ANTI-ATHEROSCLEROTIC POTENTIAL OF PIOGLITAZONE AND N-ACETYLCYSTEINE

Atherosclerosis involves disturbances in endothelium and the resultant cascade of inflammatory reactions involving generation of ROS (Reactive Oxygen Species). Peroxisome proliferator-activated receptor-g (PPAR-g) receptors are more expressed during atherosclerosis process and its stimulation results in inhibition of formation of atherosclerotic plaque. N-acetylcysteine (NAC) stimulates GSH (gluta...

Shaival B. Shah , Mehul R. Chorawala* and Gaurang B. Shah

Department of Pharmacology, K. B. Institute of Pharmaceutical Education and Research, Gh-6, Sector-23, Gandhinagar - 382023, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).434-42

434-442

1410

433

19.

IN VITRO AND IN VIVO EVALUATION OF ACECLOFENAC LYOPHILIZED ORALLY DISINTEGRATING TABLETS

Aceclofenac, a non-steroidal anti- inflammatory drug, with poor solubility and bioavailability was taken as candidate for enhancement of in vitro dissolution and in vivo bioavailability. Development of Aceclofenac orally disintegrating tablet (ODT) using lyophilization technique was adopted. The ODTs were prepared by freeze-drying an aqueous dispersion of Aceclofenac, matrix former, filler (sugar ...

Mohamed Aly Abd El Aziz Aly El Degwy*, Saydia Tayel, Mohamed A. El-Nabarawi and Randa Tag A. El Rehem

Formulation Section Head, Mepaco Pharmaceutical Company, 141- Street, Ahmed Zaki, Maadi, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).443-59

443-459

1648

624

20.

A FACTORIAL STUDY ON THE EFFECTS OF HYDROXYPROPYL β CYCLODEXTRIN AND POLOXAMER ON THE SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE

The objective of the study is to evaluate the individual and combined effects of hydroxy propyl β cyclodextrin (HPβCD), surfactant (Poloxamer 407) on the solubility and dissolution rate of nimesulide, a BCS class II drug in a series of 22 factorial experiments. The solubility of nimesulide in four selected fluids containing HPβCD and Poloxamer 407 as per a 22 factorial study was determined. HP...

K.P.R. Chowdary*, K. Surya Prakasa Rao and Venu Sunkavalli

University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam- 530 003, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).460-64

460-464

2284

496

21.

BIOCHEMICAL AND ANTIMICROBIAL STUDY OF BOERHAVIA ERECTA AND CHROMOLAENA ODORATA (L.) KING & ROBINSON

Purpose: The present study was designed to evaluate the phytochemical, biochemical and antimicrobial activity of leaf extracts of   Boerhavia erecta and Chromolaena odorata. Methods: The leaves of Boerhavia erecta and Chromolaena odorata were washed with tap water followed by distilled water. The cleaned leaves were shade dried and then made to fine powder by using homogenizer. Ab...

M. Suriyavathana*, G. Parameswari and S. Penislus Shiyan

M. Sc., M. Phil., Ph. D, Assistant Professor, Department of Biochemistry, Periyar University, Salem- 636011, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).465-68

465-468

2101

736

22.

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF CEFIXIME TRIHYDRATE AND ITS DEGRADED PRODUCTS FORMED UNDER STRESS CONDITION OF UV LIGHT

A simple, accurate, precise and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method for the determination of cefixime trihydrate and its degraded products have been developed and validated. Drug was resolved on a C18 column (waters spherisorb 25 cm × 4.6 mm, 5µm), utilizing mobile phase of sodium dihydrogen phosphate monohydrate (0.1M aqueous) pH adjusted to 2.5 with ...

Elsadig H. K. Adam , Ahmed E. M. Saeed* and Izzeldin E. Barakat

Department of Chemistry, Collage of Science, Sudan University of Science and Technology

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).469-73

469-473

1534

541

23.

ANTI-OXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF SYNTHESIZED 3(SUBSTITUTED) CHROMEN-2-ONE

This study was designed to investigate the in vitro anti-oxidant and in vitro anti-inflammatory potential of synthesized 3(Substituted) Chromen-2-one. Anti-oxidant activity has done by DPPH, NO and H2O2 free radical scavenging activity, ascorbic acid was used as a standard. Anti-inflammatory activity has done by membrane stabilization method; aceclofenac sodium was used as standard. The presence o...

B. Lakshmi Narayanan*, L. A. Pradeep Rajkumar , A. Arulanandham , N. Satheesh Babu T. Gayathri and A. Raju

M. Pharm, (Ph. D)., Asst. Professor, Dept. of Pharmaceutical Chemistry, Karpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore- 41032, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).474-78

474-478

1361

466

24.

EVALUATION OF ACUTE AND SUBACUTE TOXICITY OF ALCOHOLIC EXTRACT OF THE ROOTS OF TRAGIA CANNABINA IN RATS

The toxicity profile of alcoholic extract of roots ofTragia cannabina Family: Euphorbiaceae was studied in wistar rats. The multiple oral administration of extract at single dose of 100, 500, 1000, 2000 and 3000 mg/kg body weight for 24 hrs. did not produce sign of toxicity, behavioral appearance, change on a gross appearance. The sun-acute toxicity was determined by administration of graded dosag...

R. K. Patel *, S.B. Patel and J. G. Shah

Assistant Professor, Department of Pharmacology, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidya Nagar, Anand, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).479-82

479-482

1109

448

25.

ASSESSMENT OF COMPLIANCE TO TREATMENT AMONG AMBULATORY ASTHMATIC PATIENTS IN A SECONDARY HEALTH CARE FACILITY IN NIGERIA

This study assessed the level of compliance using three different methods: pill count, self report and peak expiratory flow rate, in asthmatic patients attending a secondary health care facility. Self report (using a pre-tested structured questionnaire), peak expiratory flow rate and pill count were used to assess patient’s compliance and identify the factors which may be responsible for non com...

A. A. Obasan, S. J. Showande* and T. O. Fakeye

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).483-89

483-489

1276

477

26.

ANTIMICROBIAL ACTIVITY OF SOME MEDICINAL HERBAL EXTRACTS ON CLINICALLY IMPORTANT BACTERIAL PATHOGENS

The antibacterial activity of methanol extract of Abutilon indicum, Hygrophila spinosa and Mimosa pudica were studied by agar well diffusion method in vitro.  The effect of antibacterial potential was examined against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Proteus vulgaris, Enterococcus faecalis, Klebsiella pneumoniae, Vibrio cholerae, Salmonella typhi a...

J. Suriya*, Raja S. Bharathi, V. Sekar and R. Rajasekaran

Research Scholar, Centre of Advanced study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai- 608 502, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).490-93

490-493

1301

507

27.

PURIFICATION AND CHARACTERIZATION OF RIBOFLAVIN BINDING PROTEIN FROM THE EGG WHITE OF EAGLE (AQUILA HASTATE)

Riboflavin binding protein (RfBP) was isolated from the eggs of Aquila hastate (eagle). The protein was purified in two steps, DEAE – Sepharose ion exchange chromatography and gelfilteration on Sephadex G-100. The holoprotein had an absorption spectrum characteristic of flavoproteins. The purity of the protein was judged by SDS-PAGE technique. A single band on the slab and cylindrical gel reveal...

Madhkar Rao Kudle*, Satheesh Kumar Boddu and Prasad MSK

Department of Biochemistry, Kakatiya University, Warangal- 506 009, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).494-96

494-496

1149

413

28.

ANTIBACTERIAL ACTIVITY OF SIMAROUBA GLAUCA LEAF EXTRACTS AGAINST FOOD BORNE SPOILAGE AND PATHOGENIC MICROORGANISMS

Crude ethanol and methanol extracts from dried and fresh leaves of Simarouba glauca were tested for their inhibitory activity against two food borne pathogenic microorganisms (Staphylococcus aeureus and Escherichia coli) and two food spoilage microorganism (Bacillus subtilis and Pseudomonas aeurogenosa). Screening for antimicrobial activity using well diffusion assay showed the inhibition against ...

B. L. Jangale*, T. B. Ugale , P. S. Aher , N. R. Toke , A. N. Shivangikar and N. T. Sanap

Assistant Professor, Department of Plant Biotechnology, K. K. Wagh College of Agricultural Biotechnology, Saraswati Nagar, Panchavati, Nashik- 422 003, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).497-00

497-500

2193

1957

29.

PREPARATION AND CHARACTERIZATION OF CINNARIZINE FLOATING OIL ENTRAPPED CALCIUM ALGINATE BEADS

Gastroretentive delivery systems can be retained in the stomach and assist in improving absorption and consequently the bioavailability of drug that has a narrow absorption window in a particular region of gastrointestinal tract. A floatable multiparticulate system with potential for intragastric sustained delivery is one of the approaches to get the gastroretention. Cinnarizine(CNZ), an antihista...

Mowafaq M. Ghareeb*, Anmar A. Issa and Ahmed A. Hussein

Department of Pharmaceutics, College of Pharmacy, Baghdad University, Baghdad, Iraq

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).501-08

501-508

1686

775

30.

PUNICA GRANATUM ATTENUATES SCIATIC NERVE LIGATION INDUCED-NEUROPATHIC PAIN

The study has been designed to investigate the effect of aqueous extract of rind of Punica granatum in sciatic nerve ligation induced-neuropathic pain in rats. Surgical procedure was performed with sciatic nerve ligation to develop neuropathic pain in rats. The development of neuropathic pain was assessed by employing behaviour parameters such as hyperalgesia and allodynia. Further, the functional...

Sukhvir Kaur, A. C. Rana, Shaveta Gangwani and Ramica Sharma

M. Pharma (Pharmacology), Rayat Institute of Pharmacy, Railmajra Distt Saheed Bhagat Singh Nagar-144514, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).509-18

509-518

1627

524

31.

EFFECT OF ADMINISTRATION OF ETIZOLAM ON THE DEVELOPMENT OF THE CHICK EMBRYO

There are various drugs used in daily life. Some of them show hazardous effect on various organs and some of them shows even lethal effect. Such drugs are required to banned. One of them is Etizolam   (marketed  under  the  brand  name  Sedekopan, Pasaden or Depas)  is a drug   which is a thiebenzothiodiazepines  analog. The aim of this work is done to compare the effect of administrati...

Shweta P. Alai* and Nivrutti G. Sonone

K.K. Wagh College of Agricultural Biotechnology, Nashik, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).519-22

519-522

1544

580

32.

DESIGN, SYNTHESIS AND CYTOTOXIC ACTIVITY OF SOME NOVEL FLAVONES

A series of flavones (5-15) weresynthesized from resorcinolvia Baker-Venkataraman transformation, characterized and evaluated for their cytotoxicity against human cervical cell line (HeLa) by MTT assay method. The result of preliminary MTT cytotoxicity studies shown that the compounds 5, 9 and 10 were found to be most potent against HeLa cells;  IC50 values were of 0.22, 0.88 and 1.26 µM respect...

Palani Venkatesh*, Govindaraman Prakash and Parasuraman Pavadai

Department of Medicinal Chemistry, Mother Theresa post graduate and Research Institute of Health Sciences, Pondicherry University, Puducherry-605006, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).501-08 http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).523-27

523-527

1346

444

33.

EFFECT OF WATER STRESS BY POLYETHYLENE GLYCOL 6000 AND SODIUM CHLORIDE ON SEED GERMINATION AND SEEDLING GROWTH OF CASSIA ANGUSTIFOLIA

The impact of salt stress and water stress on seed germination, root and shoot length, fresh and dry biomass, vigour index was investigated in Senna (Cassia angustifolia) at germination stage (7DAS). Salinity stress was induced by using NaCl and drought stress by using PEG-6000. Different concentration of NaCl (0.1 to 100 mM) and PEG-6000(-0.1 bars to -2.0 bars) were used for seed treatment. The o...

S. M. Shitole and K. N. Dhumal

Ph. D., Scholar, Department of Botany, University of Pune, Pune- 411007, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).528-31

528-531

2241

546

34.

DISINTEGRANT EFFECT OF FINGER MILLET (ELEUSINE COROCANA) STARCH ON DISSOLUTION PROFILE AND DISINTEGRATION TIME IN HIGH DOSE TABLETS

Starch was extracted from the grains of finger millet (Eleusine corocana), by steeping in water for 24 hours. The extracted starch was used as a disintegrant, at the concentrations of 2.5-12.5%w/w to compressed paracetamol tablet in comparism with maize starch BP. Results show that, there is no significant difference in the disintegration time or dissolution rate of tablets containing the two star...

S.U. Shiihii*, H. Musa , P.G. Bhatia and T.S. Allagh

Pharmacists Council of Nigeria, Lagos

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).532-35

532-535

1379

447

35.

UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SECNIDAZOLE IN BULK AND TABLET DOSAGE FORM

A simple, precise and accurate UV-Spectrophotometric method has been developed and validated for estimation of secnidazole in bulk and tablet dosage form. It shows maximum absorbance at 313 nm with methanol and water (30:70). Estimation was carried out by A(1%1cm) and by comparison with standard. Calibration graph was found to be linear (r2 =0.09998) over concentration range of 1-4µg/ml. The prop...

Jinendra M. Sonpetkar*, Deval V. Joshi, Nakul B. Patel and Mansi J. Wagdarikar

Indira College of Pharmacy, Tathwade, New Mumbai-Pune Highway, Pune- 411041, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).536-38

536-538

1706

1401

36.

FORMULATION AND EVALUATION OF MICROCAPSULES OF TRIHEXYPHENIDYLE HYDROCHLORIDE BY SOLVENT EVAPORATION METHOD.

Trihexyphenidyle is a lipophilic antiparkinsonian drug with short half life. Practically slightly soluble in water makes formulation and delivery difficult. By formulating the same in the microcapsule by using biodegradable polymer Eudrajit L 100 and S 100, the half life and solubility can be altered and hence drug release pattern. Trihexyphenidyle microcapsules were prepared by solvent evaporatio...

Hima V. Pandya*

Department of Pharmaceutics, Shree Devi College of pharmacy, Mangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).539-44

539-544

9307

1325

37.

COMPARATIVE QUALITY EVALUATION OF PARACETAMOL TABLET MARKETED IN SOMALI REGION OF ETHIOPIA.

The safety and efficacy of a pharmaceutical dosage form can be guaranteed when its quality is reliable. The efficacy of pharmaceutical dosage forms generally depends on their formulation properties, and manufacturing methods, hence it is likely that the quality of dosage form may vary. The aim was to evaluate the quality of paracetamol tablet marketed in Somali region of Ethiopia. The study was ex...

Samuel Belay Sahle , Amene Tesfaye Ayane , Nasir Tajure Wabe*

Lecturer, Clinical Pharmacy Unit, Pharmacy Department, College of Public Health and Medical Science, Jimma University, P.O.BOX 251 1480, Jimma, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).545-50

545-550

3618

1104

38.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF CEFPODOXIME PROXETIL AND OFLOXACIN IN TABLETS

The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of cefpodoxime proxetil and ofloxacin in combined tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Cefpodoxime proxetil has absorabance maxima at 236 nm and ofloxacin h...

M. N. Shah*, Dr. H. U. Patel and C. N. Patel

Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Nr. Arvind Baug, Mehsana- 384001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).551-55

551-555

1662

524

39.

EVALUATION OF SYZYGIUM CUMINI LINN. SEED FORMULATIONS AVAILABLE IN THE MARKET USING SPECTROPHOTOMETRIC AND CHROMATOGRAPHIC TECHNIQUES

Most of the plant parts of Syzygium cumini aredocumented in the traditional systems of medicine in India for their key usage as a hypoglycemic in the management of diabetes. Many such formulations of Jamun fruits/seed powder are available in the market. Hence, in the present investigation, the detailed pharmacognostic evaluation of Syzygium cumini seed powders has been carried out to develop a fas...

K. S. Chitnis*, S. B. Palekar , D. R. Koppar and D. Y. Mestry

Assistant Professor, Department of Life Sciences, Ramnarain Ruia College, L.N. Road, Matunga (E), Mumbai -400019, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).556-60

556-560

1586

1097

40.

STUDIES OF DRUG-POLYMER INTERACTIONS OF SIMVASTATIN WITH VARIOUS POLYMERS

The purpose of the present study is to prepare different combinations of drug Simvastatin (SV) with different polymers like Sodium alginate (SA), Hydroxypropylmethylcellulose (HPMC), Pectin (P), Dillenia (D) and Hydroxy propyl β- cyclodextrin. (HPC), thereby determine and report any possible interactions between the drug Simvastatin (SV) and various polymers both from natural and synthetic source...

Trishna Bal* and P. N. Murthy

Assistant Professor, Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).561-63

561-563

1629

544

41.

ISOLATION OF PENICILLIUM SP. AND ITS ANTAGONISTIC ACTIVITY AGAINST DERMATOPHYTES FROM VOLCANO SOIL OF BARATANG ISLAND, ANDAMAN

Penicillium sp. was isolated from the mud volcano of Baratang Island, Andaman, were tested for the growth inhibition against four fungal species of dermatophytes viz., Epidermophyton flococususm, Microsprum gypseum, Tricophyton rubrum, Tricophyton mentagraphytes. Three different concentration of fungal suspension (10µl, 25 µl and50 µl) were tested using disc diffusion method.  Penicillium sp. ...

A. Dhinakaran*, M. Kalaiselvam, V. Sekar and G.V.B. Sethubathi

Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai- 608 502, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).564-68

564-568

1484

601

42.

FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF PREGABALIN

The objective of present study is to determine the permeation of Pregabalin from transdermal patch into microcirculation of skin. Matrix type transdermal drug delivery system (TDDS) of Pregabalin was prepared by the solvent evaporation technique. Several batches were prepared by using combination of HPMC and PVP; PVA and PVP; Eudragit RL-100 and Eudragit RS-100; HPMC and EC in different ratios. Pr...

Chakshu Bhatia*, Monika Sachdeva and Meenakshi Bajpai

Department of Pharmacy, Raj Kumar Goel Institute of Technology, Ghaziabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).569-75

569-575

13488

904

43.

PHARMACY PRACTICE IN VIEW OF HEALTH PROFESSIONALS IN JIMMA UNIVERSITY SPECIALIZED HOSPITAL

Background: Pharmacists are drug therapy experts and primary health professionals who optimize medication management to produce positive health outcomes. Clearly there are still misconception and confusion among the public on the function of pharmacists. Sometimes even the pharmacy personnel themselves seemed to be unaware of the importance of their profession. Objective: The study tried to ass...

Dagim Ali Hussen*, Hailemeskel Mekonnen Alemu , Mohammedmekin Mohammedseid Mohammednur , Meaza Girma Raya and Gebremedhin Solomon Hailu

Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).576-82

576-582

1558

455

44.

LINEAR RESPONSE APPROXIMATION (LRA) APPROACHES FOR CALCULATING BINDING AFFINITIES OF QUINAZOLINE ANALOGUES AS ALK5 INHIBITORS

Quinazoline and its analogues have important therapeutic value in the treatment of cancer to induce apoptosis in cancer cells in a proliferation-independent manner. The binding free energies of quinazoline based inhibitors of kinase were computed using linear interaction energy method with a surface generalized Born (SGB) continuum solvation model in the human ALK5 kinase domain. A training set of...

Md. Afroz Alam*, Thalitha Jane Davina and Anurupa Devi

Assistant Professor (SG), Department of Bioinformatics, Karunya University, Karunya Nagar, Coimbatore, 641114, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).583-95

583-595

1464

596

45.

CYTOLOGICAL STUDIES OF TWO SPECIES OF GENUS DELONIX

Many cytological characteristics were studied in two species of Genus Delonix  i.e., D. regia and D. elata . Delonix regia possessed 2n = 28 chromosome number. Both univalent as well as bivalents occurred invariably in this plant species, the former type being predominant over latter type. The chiasma frequency per PMc varied from 8-12 with average being 15.82. The chiasma frequency per chromosom...

Payal Chandrawat*, Daulat Singh, Santosh K. Sharma and Ramavtar Sharma

Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).596-99

596-599

1505

395

46.

HYPOGLYCEMIC EFFECT OF 2-HYDROXYCHALCONE ON HIGH FRUCTOSE FED DIABETIC RAT

The objective of the project work was to study the effect of Hypoglycemic and Hypolipidemic activity of 2- hydroxychalcone on high fructose diet induced insulin resistance in male Wister Albino rats. Rats were rendered insulin resistant by feeding 66% (w/w) fructose and 1.1% (v/w) coconut oil mixed with normal pellet diet (NPD) for 3 weeks. Insulin resistance high fructose diabetic rats receiving ...

M. Jayanthi , K. Jegatheesan*, R.Vidhya and U. Kanagavalli

Assistant Professor, Department of Biochemistry, Adhiparasakthi College of Arts & Science, G. B. Nagar, Kalavai, Vellore Dist-632 506, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).600-04

600-604

1621

466

47.

EFFECT OF TRIGONELLA FOENUM GRAECUM ON LACTATE DEHYDROGENASE (LDH) ACTIVITY OF BLOOD, LIVER AND PANCREAS IN NORMAL AND ALLOXAN- INDUCED DIABETIC MICE

The effect of aqueous seeds extract of Trigonella foenum graecumLinn was studied on Lactate dehydrogenase (LDH) activity of blood, liver and pancreas in normal and alloxan- induced diabetic mice. Our study showed that aqueous seeds extract, Oral administration of 50 mg/animal (0.5 ml of extract) in alternative days up to 7 days (1st, 3rd, 5th & 7th day). In alloxan induced diabetic mice, there...

Dharmaseelan Sarasa , Sekaran Sridhar* and Egambaram Prabakaran

Department of Botany, Govt. Arts College, Thiruvannamalai 606 603, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).605-09

605-609

1398

475

48.

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACETAMINOPHEN

The present research work has been carried out for an optimized formulation of co-processed directly compressible vehicles in the preparation of the Acetaminophen mouth fast dissolving tablets (MFDTs). Acetaminophen was chosen due to its poor compression properties. Di-calcium Phosphate(DCP) was incorporated in the neutralized aqueous starch dispersion to prepare co-processed excipient. Co-process...

Abhay Kumar Mourya*, Sunil K. Prajapati , S.K. Jain , Ajay Kumar, Atul Kumar Thakran and Shashi Alok

Institute of Pharmacy, Bundelkhand University,Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).610-14

610-614

2802

778

49.

IN-VITRO EVALUATION OF NITRIC OXIDE SCAVENGING ACTIVITY OF METHANOLIC AND AQUEOUS EXTRACT OF SYZYGIUM CUMINI LINN. BARK (MYRTACEAE)

Plants have provided mankind with herbal remedies for many diseases for many centuries and eventody. In India, herbal medicines have been the basis of treatment and cure for various diseases in traditional methods practiced such as Ayurveda, Unani and Sidha. Syzygium cumini Linn. (Myrtaceae) commonly known as jambul tree (English), having promising theraputic values with its various phytoconstitue...

Kuncha Jayachandra*, Ayyachamy Maheswaran , Mariappan Murali

Assistant Professor, Department of Pharmaceutical Chemistry, Jaya College of Paramedical Sciences College of Pharmacy, C.T.H Road, Thiruninravur, Chennai- 602024, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).615-19

615-619

1540

654

50.

EVALUATION OF AEGLE MARMELOS FRUIT MUCILAGE FOR BINDING PROPERTIES

Plant products served as an alternative to synthetic products because of local accessibility, eco friendly nature and lower prices. Natural gums and mucilages are widely explored as pharmaceutical excipients. The present study was undertaken to separate mucilage from unripe fruits of Aegle marmelos (L) Corr. and explore its use as binder in tablets. The binding properties at different concentratio...

N. Gaikar and P. Sandhya

Department of Pharmacognosy, Saraswathi Vidya Bhavan’s College of Pharmacy, Dombivli (E), Dist-Thane, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).620-22

620-622

1520

484

51.

SYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES BY JUSTICIA GENDARUSSA BURM F. LEAF EXTRACT

The unusual physio and chemical properties of gold nanoparticles are found to have more advantage in the field of medicine, diagnostics and biosensors. In the present document,   it is reported that Justicia gendarussa leaf extract mediated synthesis of gold nanoparticles by the reduction of gold ions. Three different phytochemical fractions were prepared from methanolic leaf extract by liquid-l...

Manickam Chinna , Ponnuswamy Renuka Devi*, Asthanari Saravanakumar Venseslas Femi , Eswaran Hemananthan , Soundharajan Senthil Rani

Biotechnology centre, Anna University of Technology, Coimbatore- 641047, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).623-29

623-629

1493

679