Volume 4 (2013) - Issue 4, April
Review Articles
CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW. PART V. BIOLOGICAL PROFILE
Crinum is a well-known traditional herb belongs to family Amaryllidaceae. Worldwide, different Crinum species are commonly used to treat various conditions due to their excellent medicinal values. Members of this genus are also best known biofactories for the unique Amaryllidaceae alkaloids. Due to the significant phytoconstituents produced by this plant as well as their therapeutic potentials, ma...
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A REVIEW ON HELIOTROPIUM INDICUM L. (BORAGINACEAE)
Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’ is very common in India with a long history of traditional medicinal uses in many countries in the world. The plant is reported to possess antibacterial, antitumor, uterine stimulant effect, antifertility, wound healing, anti-inflammatory, antinociceptive and diuretic activities. Several pyrrolizidine alkaloids have been isolate...
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TARGETING ONCOGENIC KINASE SIGNALING WITH SMALL MOLECULE KINASE INHIBITOR IMATINIB
Protein tyrosine kinases (PTKs) are key players in cellular signal transduction events and have essential roles in cell growth, survival, differentiation and migration. Perturbations in protein tyrosine kinase activity have been implicated in a number of abnormalities, particularly cancer. Selective small molecule inhibitors are potential therapeutic agents targeting protein kinases involved in ca...
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NUTRITIONAL AND HEALTH IMPLICATIONS OF LEGUMES
Legumes are plants in the family Fabaceae characterized by seeds in pods that are often ediblethough sometimes poisonous. The nutrient content (protein, carbohydrate and micronutrients) of legumes contribute to address under-nutrition, especially protein-calorie malnutrition among children and nursing mothers in developing countries where supplementing cereal-based diets with legumes is suggested ...
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ANALYTICAL METHOD VALIDATION: AN UPDATED REVIEW
The development of sound Analytical method(s) is of supreme importance during the process of drug discovery, release to market and development, culminating in a marketing approval. The objective of this paper is to review the method development, optimize and validation of the method for the drug product from the developmental stage of the formulation to commercial batch of the product. Method deve...
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DRUG DELIVERY METHODS RANKING ADDICTION POTENTIAL
Substance abusers and drug addicts generally seek the fastest and most effective methods of getting high this means that drug delivery methods are important to users, and typically an addict will prefer one method over another. However, because there are a wide variety of drug delivery methods, substance abusers will often fluctuate between these techniques when the need arises. Understanding th...
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AN OVERVIEW ON EXPLORING NASAL MICROEMULSION FOR TREATMENT OF CNS DISORDERS
Nasal route is found to be valuable for targeting drugs to CNS via different mechanisms. The advantages, disadvantages, varius aspects of nasal anatomy and physiology, mechanism of drug transport from nose brain, drug selection criteria to cross BBB/Blood-CSF barrier are discussed briefly. The relevant aspects of physicochemical, formulation and physiological factors of nasal cavity that must be c...
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SYNTHETIC APPROACHES FOR BIS (INDOLYL) METHANES
Indole ring system is the most important heterocycle available in natural compounds. Owing to great structural diversity, the indole ring system has become an important structural requirement in many pharmaceutical agents. Indole has been widely identified as a privileged structure or pharmacophore, with its presence in over 3000 natural isolates which are known to possess broad spectrum of biolog...
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IS EMERGENCY CONTRACEPTIVE ACCESSIBILITY A BARRIER IN DEVELOPING COUNTRIES? A REVIEW
Significant portion of maternal death in developing countries was attributed to induced abortions secondary to unwanted pregnancies. Using emergency contraception as a backup method can contribute to reduce unwanted pregnancy secondary to method failure, contraception non-use and also rape. The need for emergency contraception is clearly demonstrated by the occurrence of unwanted pregnancy and i...
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CONTEMPORARY APPROACHES FOR BI-LAYER TECHNOLOGY OF DRUGS THROUGH ORAL ROUTE: AN OVERVIEW
Bi-layer tablet technology for bimodal release of drug and co-administration of drugs via oral route has been engaged a significant place in the field of drug delivery technology. At present, several pharmaceutical companies are developing bilayer tablet for co-administration of drugs to improve the therapeutic efficacy as well as to reduce the chances of drug-drug interaction. This review indicat...
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IMPACT OF VITAMINS IN PREVENTION OF RISK FACTORS ASSOCIATED WITH TYPE-2 DIABETES MELLITUS
Diabetes mellitus is one of the most common metabolic disorders that cause micro and macro vascular complications. Because of additive effects of hyperglycaemia and hyperlipidaemia for cardiovascular disease, serum lipid and glucose level should be closely monitored in diabetes. Chronic Hyperglycaemia resulting from diabetes has profound effects on nearly every system of the body. The toxic effect...
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NON-INVASIVE PRENATAL DIAGNOSIS: A REVIEW
Aneuploidies are one of the important causes of perinatal morbidity and mortality. Initially screening for aneuploidies started with maternal age risk estimation. Later on, serum testing for biochemical markers and ultrasound markers were added. Women detected to be at high risk for aneuploidies were offered invasive testing. Recently, various methods including non-invasive prenatal testing (NIPT)...
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EXPRESSION OF FULLY FUNCTIONAL GPCR IN E. COLI
One-third of eukaryotic proteins are associated with membranes and these membrane proteins (MP) represent approximately 50% of pharmacological targets. Researchers are therefore nursing the hope of achieving a higher percentage of about 80% in the near future. The only bottleneck to achieving this target is the experimental challengers associated with the production, purification and crystallizati...
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Research Articles
ROLE OF THE PHARMACEUTICAL CARE IN THE MANAGEMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS
Objective: The study was designed to evaluate the efficiency of pharmaceutical care on the control of clinical parameters, such as fasting glycaemia and glycosylated haemoglobin also to assess drug therapy problems in patients with type 2 diabetes mellitus. Setting: the study was conducted at Diabetic Center in Sulaimany/Iraq, during 18 September 2010 -20 January 2011. Methods: A prospective an...
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ANTIHYPERGLYCAEMIC ACTIVITY OF ETHANOLIC EXTRACT OF THE STEM OF ADENIA LOBATA ENGL (PASSIFLORACEAE)
Adenia lobata Engl (Passifloraceae) is a woody climber which grows in most African countries mainly the coastal belt. It is an important medicinal plant used to treat haemorrhoids, malaria, fever, diabetes and gonorrhea. In our attempt to find out the constituents of this medicinal plant, the dried stem powder of A. lobata was successively extracted by Soxhlet with petroleum ether and 70% ethanol ...
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ASSESSMENT OF ANTIOXIDANT, CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT FRACTIONS OF CRUDE EXTRACT OF STEPHANIA JAPONICA STEM
The different fractions of crude methanolic extract of stem of Stephania japonica (Thunb.) Miers was evaluated for antioxidant, cytotoxic and antibacterial activities. The various fractions of S. japonica Stem i.e. Ethyl Acetate (EAJS), CHCl3 (CFJS), CCl4 (CTJS) and Petroleum ether (PEJS) were subjected to free radical scavenging activity. In this investigation, CFJS showed the most significant fr...
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COMPARATIVE QUALITY EVALUATION OF SOME METRONIDAZOLE TABLETS AND METRONIDAZOLE BENZOATE ORAL SUSPENSIONS AVAILABLE IN RETAIL OUTLETS OF ADDIS ABABA, ETHIOPIA
In this study, five different products of each metronidazole tablets and benzoate salt oral suspensions were purchased from the different retail outlets in the local market of Addis Ababa and analyzed using official methods (Pharmacopoeial methods of USP/BP/IP) by employing HPLC for the tablet dosage forms and non-aqueous titration with potentiometric end point for the suspensions. The assay resul...
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ANTIDIABETIC EFFECTS OF ACACIA TORTILIS SEED EXTRACT IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS
The concerned study reveals the first time experimental investigation of Hypoglycemic and antihyperglycemic effect of seed extract of Acacia tortilis plant was in normoglycaemic and Alloxan-induced (135 mg/Kg body weight intraperitoneally) diabetic rats. The seed extract at the dose of 100 and 200 mg/kg body weight was administered orally once a day for 13 days and at the end of the experimentatio...
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EFFECT OF NATURAL AND SYNTHETIC POLYMER ON RELEASE OF KETOTIFEN FUMARATE MATRIX TABLETS: A SUSTAINED RELEASE DOSAGE FORM
With the blend of Methocel K15, a synthetic polymer and xanthan gum, a natural polymer (3:1) was used in the formulation of matrix tablets to find out the effect of natural polymer in the sustained release dosage form. Direct compression process was applied for the preparation of Ketotifen fumarate tablets. The dissolution profiles were carried out by USP apparatus 2 (paddle) at 50 rpm in 500 ml 0...
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PHYTOCHEMICAL EVALUATION AND HPTLC PROFILING OF EXTRACTS OF SALACIA OBLONGA
Plants of medicinal importance though are quite well known among the Ayurvedic practitioners since years, yet many of them have not been standardized, validated and documented completely. Among such medicinally valuable plants, Salacia holds a place as an effective antidiabetic herb and many species of this plant are in use as anti-diabetics. The present study reports the phytochemical analysis of...
4114
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DEVELOPMENT AND VALIDATION OF UV METHOD OF TEMOZOLOMIDE IN BULK AND CAPSULE FORMULATION
An UV spectrophotometric method for the quantitative determination of Temozolomide (TMZ) in bulk and capsule was developed in present work. The parameters linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to International Conference on Harmonization guidelines. UV spectroscopic determination wa...
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ANTICONVULSANT AND SEDATIVE EFFECTS OF LEAF EXTRACT OF SOLANUM PUBESCENS
The herbal preparation of the leaves of Solanum pubescens Pers (Solanaceae) is used in traditional medicine for the treatment of Epilepsy and febrile convulsions. A pilot study has confirmed the potency of the leaf of Solanum pubescens in the control of seizure in mice. The current study was aimed to identify the active phytochemical responsible for the activity. Results indicated that methanolic ...
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ISOLATION AND CHARACTERIZATION OF BIOACTIVE ACTINOMYCETES FROM SOIL IN AND AROUND NAGPUR
ABSTRACT: Fifteen soil samples were collected from different locations near Nagpur i.e. from Nagpur, Bhandara and Chandrapur. Air drying and pre-treatment of soil samples with CaCo3 (1%) were found to be most effective for isolation of actinomycetes. Five different selective media were used for the isolation of actinomycetes and the best growth was observed in yeast malt extract agar medium with 1...
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STUDIES ON THE ANTI-INFLAMMATORY AND ANALGESIC EFFICACY OF SCINDAPSUS OFFICINALIS (ROXB.) SCHOTT IN LABORATORY ANIMALS
This research was focused on the qualitative and quantitative evaluation of anti-inflammatory and analgesic effects of ethanolic extract of Scindapsus officinalis (EESO) fruit in laboratory animals and whether these effects were of any statistical significance. Carrageenan-induced Hind Paw Edema test in long evans rat was the experiment for anti-inflammatory activity of the ethanolic extract of ...
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AQUEOUS ROOT EXTRACT OF THE ANTIMALARIAL HERBAL CRYPTOLEPIS SANGUINOLENTA (LINDL.) SCHLTR DELAYS THE DEVELOPMENT OF PHYSICAL LANDMARKS AND SENSORIMOTOR SYSTEMS IN MICE
We demonstrated previously that the aqueous root extract of Cryptolepis sanguinolenta (cryptolepis), with cryptolepine as the major constituent adversely affect reproduction and foetal development in mice. However, very little is known on the effect of prenatal exposure of cryptolepis on the post-natal life of surviving animals. Using murine models, we report here, the effects of prenatal exposu...
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ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF THE PLANT ERVATAMIA CORONARIA (STAPF.)
The present study was conducted to evaluate the analgesic and anti-inflammatory potential of the flowers of Ervatamia coronaria. The analgesic activity of the extract was assessed by the acetic acid induced writhing test. Aspirin was used as a standard drug. The anti-inflammatory activity was evaluated by carrageenan induced rat hind paw edema method. The initial paw volume was measured plethysm...
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PREVENTION OF RADIATION INDUCED HEMATOLOGICAL ALTERATIONS IN MICE BY ALSTONIA SCHOLARIS EXTRACT
Backround: The present study has been carried out to evaluate the radio-protective effects of Alstonia scholaris extract (ASE) on peripheral blood of mice. Materials & Methods: Male Swiss albino mice were selected from an inbred colony and assorted into 4 groups. Animals in Group I were administered with double distilled water (DDW), volume equal to ASE, by oral gavage to serve as vehicle t...
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SELF-MEDICATION AMONG DENTAL UNDERGRADUATE STUDENTS: A GROWING CONCERN
Background: Self-medication is an important component of self-care. Though it is widely practiced globally, very few studies have evaluated its pattern and prevalence in dental students. Aim: The study was conducted to compare pattern of self-medication practices between junior and senior dental undergraduate students. Methods: This was a cross-sectional, anonymous, descriptive study with a ...
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PRELIMINARY ANTIMICROBIAL ACTIVITY AND CYTOTOXICITY OF PLANT EXTRACTS (ROOTS) OF COCCINIA GRANDIS (FAMILY: CUCURBITACEAE) h
In the present study, the in vitro antimicrobial and cytotoxic activity of root extract of Coccinia grandis were evaluated. Ethanolic crude extract with its various solvent soluble fractions of C. grandis showed significant antimicrobial activity by disc diffusion method on some gram positive and gram negative bacteria. The extracts exhibited 9-12 mm (approximately) of zone of inhibition comparing...
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RP-HPLC ANALYSIS OF METFORMIN HYDROCHLORIDE AND VOGLIBOSE AND STUDY OF ITS DIFFERENT ANALYTICAL PARAMETER
A simple, specific, precise, and efficient method for the Simultaneous estimation of Metformin HCl and Voglibose tablet by a Reverse Phase-High Performance Liquid Chromatography method is developed and validated. Selected mobile phase was in a combination of acetonitrile: buffer pH- 6.5 in the ratio of 62:38. Optimized column is a stainless steel column packed with base octa decylsilyl silica gel ...
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AN OPEN LABEL PILOT STUDY TESTING THE ROLE OF CLASSICAL HOMEOPATHY IN CHRONIC ALLERGIC RHINITIS
Purpose: The prevalence of allergic rhinitis (AR) is increasing at an alarming rate throughout the world. India has an estimated number of 15-20 million patients with allergic bronchial asthma and 30-80% of these suffer from AR. So, AR is considered as a major chronic respiratory disease due to its prevalence, impact on quality of life (QoL), work/school performance and productivity, economic bu...
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IMMOBILIZATION OF TANNIN ACYL HYDROLASE FROM ASPERGILLUS NIGER
Tannin acyl hydrolase, commonly referred to as tannase (E.C. 3.1.1.20), an inducible extra-cellular enzyme produced by a number of animals, plants and microbes. In this investigation, tannase production under solid-state fermentation by using Aspergillus niger and the waste residue of cashew husk was used as substrate for obtaining the desired fermented product. After termination of fermentation g...
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CREATININE CLEARANCE AS A MARKER FOR DIAGNOSING THE SEVERITY OF PREECLEMPSIA
Background: For many years, creatinine clearance has become increasingly popular because of several advantages. The major error arises in clearance test when the timing of urine collection is inaccurate and the bladder is incompletely empty. Aim: In view of the aforementioned controversial literature, it was decided to evaluate the relation-ship between the renal changes (creatinine clearance) ...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CHROMONES BEARING 1, 5-BENZO THIAZEPINYL MOIETY
1, 5-Benzothazepinyl chromones were synthesized starting from 2, 4-diacyl phenol. The 2, 4-diacyl phenol was condensed with aryl aldehydes to obtain bis-chalcones1a-d. The bis-chalcones on cyclocondensation with equimolar amount of 2-aminothiophenol gave 1, 5-benzothiazepinyl chalcones2a-d. The chalcones on oxidative cyclisation in DMSO - I2 yielded the titled compounds3a-d. The microbial evaluati...
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IMPACT OF NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE ON C-REACTIVE PROTEIN IN OBSTRUCTIVE SLEEP APNEA PATIENTS
Obstructive sleep apnea (OSA) has been increasingly linked with cardiovascular risk factors. Mechanisms such as increased sympathetic activity and endothelial dysfunction have been implicated. There are many factors which are responsible for the cardiovascular morbidity in OSA patients they are Obesity, C-reactive protein (CRP) and lipid profile. To study the impact of nasal continuous positive ai...
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OPTIMIZATION OF THE FORMULATION AND IN-VITRO EVALUATION OF CAPECITABINE NIOSOMES FOR THE TREATMENT OF COLON CANCER
The goal of the present study was to investigate the feasibility of using non-ionic surfactant vesicles as carriers for the sustained delivery of water soluble anti-cancer drug Capecitabine, used in the treatment of colorectal cancer. The niosomal formulations were prepared using various non-ionic surfactants (span 40, span 60, tween 40 and tween 60) in the presence of cholesterol, by thin film hy...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF TELMISARTAN
The patients with sudden increase blood pressure have markedly reduced function ability and extremely restless, in such cases rapid onset of action is of prime importance. So the patients would be benefited from acute treatment by using Fast dissolving drug delivery system. Telmisartan is an Anti-hypertensive drug which is insoluble in water; hence the drug may be slowly or incompletely dissolves ...
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TESTING EFFICACY OF HERBAL DRUG “FORTEGE” IN TREATMENT OF METAL INDUCED INFERTILITY IN MALE MICE
Fertility was tested in 0.5 mM/kg b. wt. (i.p) Lanthanum chloride exposed mice. Beneficial effects of “Fortege” an ayurvedic medicine (Alarsin co. Bombay) were also tested. Lanthanum chloride affected sperm count and motility. Lanthanum chloride could have affected Sertoli cells adversely and that have reduced sperm’s ability of uptake of fructose and as a result of it sperms became unable t...
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SYNTHESIS, ANTIBACTERIAL ACTIVITY AND MOLECULAR PROPERTIES PREDICTION OF SOME PYRIDAZIN-3-ONE DERIVATIVES
We have synthesized some new pyridazine-3-one derivatives and characterized by means of IR, NMR & mass spectral data. Compounds were evaluated for in-vitro antibacterial activity by disc diffusion method and further subjected to molecular properties prediction and drug-likeness by Molinspiration software. All compounds were found in compliance with Lipinski ‘Rule of Five’ and presented a g...
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IMPACT OF SODIUM AND POTASSIUM IONS IN IDENTIFICATION OF OFFSPRING GENDER IN HAMSTERS
Impacts of sodium and potassium in diet to determine offspring gender in hamsters have been investigated. Sex determination has scientific basis for prevention of genetic diseases in addition to social backgrounds.20 healthy hamsters chosen from the first generation of the previous experimental hamsters, were divided in to two groups in the hamsters male to female 1:5. The first group was Na and...
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ANTIBACTERIAL ACTIVITY OF COW URINE AGAINST SOME PATHOGENIC AND NON-PATHOGENIC BACTERIA
Cow urine therapy and all traditional practices from Indian systems of medicine have a strong scientific base. The cow has proved to be a boon in the areas of agriculture, science and technology, industry, energy, medicine etc for the development of any nation, in addition being eco-friendly in nature. In the present study the antibacterial potentials of cow urine were investigated. Total 14 patho...
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STUDIES ON ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF OYSTER MUSHROOM PLEUROTUS FLORIDA
The antimicrobial and antioxidant activity of four different solvent extracts of P. florida were investigated. The antimicrobial activities of different solvents were tested against different bacteria and fungi using disc diffusion method. Total antioxidant, reducing power and total phenolic content effect of the extracts was determined by phosphomolybdenum assay, 2,2-diphenyl-1-picrylhydrazyl (DP...
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CAMELLIA SINENSIS LEAVES A NEW TREATMENT AGAINST URINARY TRACT INFECTION CAUSED BY PSEUDOMONAS FLUORESCENS AND SERRATIA SP
Urinary tract infection is the most common disease in females and males which is big threat of kidney failure. The increasing interest is in the powerful biological activity of medicinal plant containing bioactive compounds which paves way for the importance to determine their antibacterial activity. The bioactive chemical determination revealed the presence of bioactive constituents’ steroids, ...
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PHYTOCHEMICALS INVESTIGATION AND TLC PROFILING OF CYAMOPSIS TETRAGONOLOBA L. SEEDS (FABACEAE) – PEA FAMILY
Cyamopsis tetragonoloba L. is belongs to the family Fabaceae. It is used as herbal and as vegetable from ancient times. It is abundant in tropical region of Africa and Asia. Preliminary phytochemicals investigations have been carried out on the seed extract using n-Hexane, Ethyl Acetate, Acetone, Ethanol and Methanol solvents. Qualitative phytochemicals analysis reflects the presence of Phenol, ...
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IN VITRO ANTIBACTERIAL ACTIVITY AND CALLUOGENESIS OF BRYONIA LACINIOSA
Interest in medicinal plant as a re-emerging health aid has been fuelled by the rising cost of prescription drug in the maintenance of personal health. In present work an attempt has been made to carry out antimicrobial activity of bryonia laciniosa plant, used in Indian folk medicine. The aim of the study was to grow in vitro callus from bryonia laciniosa from leaf explants and its microbial acti...
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FACTORS AFFECTING VASECTOMY ACCEPTABILITY IN ETHIOPIA
Vasectomy is one of the most effective but less utilized types of contraception method which could addresses the involvement of males to the family planning. The aim of the study was therefore to investigate the awareness about and practice of men towards vasectomy among workers in Dashen brewery, Ethiopia. Descriptive cross sectional study was conducted using pre tested self-administered question...
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PSYCHOLOGICAL EFFECTS OF USING POWER-ENHANCING DRUGS ON GYM-EXERCISING INDIVIDUALS
Exercising in a gym, largely aimed at getting a better-shaped body, is a long and tiring process. So many people opt for power enhancing drugs, boosting their athletic performance. These include steroids, erythropoietin, creatine, protein and zinc supplements among others. Together with increasing the muscle bulk, they exert highly undesirable effects on normal physiology. The subjects were asked ...
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IMPROVEMENT OF SOLUBILITY OF BADLY WATER SOLUBLE DRUG (IBUPROFEN) BY USING SURFACTANTS AND CARRIERS
Although there was a great interest in solid dispersion systems during the past four decades to increase dissolution rate and bioavailability of badly water-soluble drugs, their profitable use has been very limited, primarily because of manufacturing difficulties and stability problems. In this study solid solutions of drugs were generally produced by fusion method. The drug along with the excipie...
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LEAD TOXICITY AND POSTNATAL DEVELOPMENT OF OVARY
Purpose: The course of human development from conception to adulthood is extremely complex. The developing organism is particularly vulnerable to toxic insult because of rapid cell division and differentiation and severely affected during gestation and lactation. The aim of the present study was to evaluate lead toxicity on the female reproductive system during neonatal period. Methods: Histopa...
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ASSESMENT OF CYTOTOXIC EFFECT OF METHANOLIC CRUDE EXTRACTS OF AZADIRACTA INDICA
The aim of the research is to observe the cytotoxic activity of methanolic crude extracts of Azadirachta indica, a plant belonging to the family Meliaceae. The root of Azadirachta indica was extracted with organic solvent and the extracts were fractionated by using three fractions (n-hexane, ethyl acetate and chloroform). The crude extracts were screened for antitumor properties using brine shrimp...
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AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECTS OF AEGLE MARMELOS AND IT’S COMPARISON WITH PIRACETAM ON LEARNING AND MEMORY IN WISTAR RATS
Present study was done to evaluate the memory enhancing effect of Aegle marmelos and its comparison with the present standard treatment Piracetam in Wistar rats. The learning and memory was assessed using the elevated plus maze. The findings of the present study indicate that, Aegle marmelos extract treated animals at a dose of 100 mg/kg p.o. as well as 200 mg/kg p.o. showed significant decrease...
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HEPATOPROTECTIVE ACTIVITY OF SCINDAPSUS OFFICINALIS FRUIT IN PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
Scindapsus officinalis (Roxb.) Schott fruits are widely used in many parts of India for the treatment of various diseases. It is one of the plants used in Indian system of medicine which belongs to family Aracea. It has the significant antioxidant property due to presence of flavonoids and phenolic compound and has ability of cytoprotection due to antioxidant property. Hydroalcoholic extract (50%E...
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SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CLOMIPRAMINE IN BULK AND TABLET DOSAGE FORM
A simple and sensitive spectrophotometric method has been developed for the determination of Clomipramine in bulk and tablet dosage forms. The method was based on the charge transfer reactions of Clomipramine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone. The absorbance of the highly intensive coloured solution was measured at 470 nm against reagent blank treated similarly. Beer’s law is obey...
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DESIGN AND EVALUATION OF SUSTAINED RELEASE MULTIPARTICULATE SYSTEM OF TIZANIDINE HYDROCHLORIDE
The aim of the present investigation is to formulate and evaluate Tizanidine hydrochloride sustained release pellets. Tizanidine hydrochloride is an immadazole α2-adrenergic agonist used in the management of increase in muscle tone associated with spasticity. It has short biological half-life of 2- 2.5 hrs and is rapidly eliminated from the body. Sustained release dosage form of Tizanidine hydroc...
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PROXIMATE, PHYTOCHEMICAL PROFILE AND ANTIOXIDANT ACTIVITY (IN VITRO AND EX VIVO) OF MORUS INDICA VARIETIES
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the...
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IN-SILICO ADMET PREDICTION OF PHYTOCHEMICALS IN CAMELLIA SINENSIS AND CITRUS SINENSIS
Camellia sinensis and Citrus sinensis are treasuries of medicinal properties. The compounds present in these plants can deliver potential therapeutic drug. Most of the drugs in clinical development fail to commercialize because of poor ADME and toxicity properties. The main aim of the study is pharmacokinetic investigation and toxicity property, the most causes of high attrition rates in drug de...
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