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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 4 (2013) - Issue 4, April

Review Articles

 
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1.

CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW. PART V. BIOLOGICAL PROFILE

Crinum is a well-known traditional herb belongs to family Amaryllidaceae. Worldwide, different Crinum species are commonly used to treat various conditions due to their excellent medicinal values. Members of this genus are also best known biofactories for the unique Amaryllidaceae alkaloids. Due to the significant phytoconstituents produced by this plant as well as their therapeutic potentials, ma...

John Refaat*, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1239-52

1239-1252

3546

1860

2.

A REVIEW ON HELIOTROPIUM INDICUM L. (BORAGINACEAE)

Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’ is very common in India with a long history of traditional medicinal uses in many countries in the world. The plant is reported to possess antibacterial, antitumor, uterine stimulant effect, antifertility, wound healing, anti-inflammatory, antinociceptive and diuretic activities. Several pyrrolizidine alkaloids have been isolate...

G. K. Dash* and M. S. Abdullah

Faculty of Pharmacy & Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, 30450 Ipoh, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1253-58

1253-1258

6828

3142

3.

TARGETING ONCOGENIC KINASE SIGNALING WITH SMALL MOLECULE KINASE INHIBITOR IMATINIB

Protein tyrosine kinases (PTKs) are key players in cellular signal transduction events and have essential roles in cell growth, survival, differentiation and migration. Perturbations in protein tyrosine kinase activity have been implicated in a number of abnormalities, particularly cancer. Selective small molecule inhibitors are potential therapeutic agents targeting protein kinases involved in ca...

Saad Farooq*, M.H. Qazi and Maria Fareed Siddiqui

Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, 1 km Defense Road Lahore, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1259-68

1259-1268

1729

489

4.

NUTRITIONAL AND HEALTH IMPLICATIONS OF LEGUMES

Legumes are plants in the family Fabaceae characterized by seeds in pods that are often ediblethough sometimes poisonous. The nutrient content (protein, carbohydrate and micronutrients) of legumes contribute to address under-nutrition, especially protein-calorie malnutrition among children and nursing mothers in developing countries where supplementing cereal-based diets with legumes is suggested ...

Mebrahtom Gebrelibanos*, Dinka Tesfaye, Y. Raghavendra and Biruk Sintayeyu

Course and Research Unit of Pharmacognosy, Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1269-79

1269-1279

5790

1568

5.

ANALYTICAL METHOD VALIDATION: AN UPDATED REVIEW

The development of sound Analytical method(s) is of supreme importance during the process of drug discovery, release to market and development, culminating in a marketing approval. The objective of this paper is to review the method development, optimize and validation of the method for the drug product from the developmental stage of the formulation to commercial batch of the product. Method deve...

G. Lavanya, M. Sunil, M.M. Eswarudu*, M. Chinna Eswaraiah, K. Harisudha and B. Naga Spandana

Department of Pharmaceutical Analysis, Anurag Pharmacy College, Ananthagiri (V), Kodad (M)- 508206, Nalgonda (Dt), Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1280-86

1280-1286

14193

1688

6.

DRUG DELIVERY METHODS RANKING ADDICTION POTENTIAL

Substance abusers and drug addicts generally seek the fastest and most effective methods of getting high this means that drug delivery methods are important to users, and typically an addict will prefer one method over another. However, because there are a wide variety of drug delivery methods, substance abusers will often fluctuate between these techniques when the need arises. Understanding th...

K. Sujatha*, T. Arundathi, S. Rubina, B.V. Ramana, G. Nagarajan

Department of Pharmaceutics, Dr. K.V. Subba Reddy Institute of Pharmacy, Dupadu, Kurnool, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1287-93

1287-1293

2318

490

7.

AN OVERVIEW ON EXPLORING NASAL MICROEMULSION FOR TREATMENT OF CNS DISORDERS

Nasal route is found to be valuable for targeting drugs to CNS via different mechanisms. The advantages, disadvantages, varius aspects of nasal anatomy and physiology, mechanism of drug transport from nose brain, drug selection criteria to cross BBB/Blood-CSF barrier are discussed briefly. The relevant aspects of physicochemical, formulation and physiological factors of nasal cavity that must be c...

Mohanish Vispute*, Sayyad Nazim, Tarique Khan and Siraj Shaikh

Department of Pharmaceutics, Ali- Allana College of Pharmacy, Akkalkuwa-425415, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1294-11

1294-1311

3183

1026

8.

SYNTHETIC APPROACHES FOR BIS (INDOLYL) METHANES

Indole ring system is the most important heterocycle available in natural compounds. Owing to great structural diversity, the indole ring system has become an important structural requirement in many pharmaceutical agents. Indole has been widely identified as a privileged structure or pharmacophore, with its presence in over 3000 natural isolates which are known to possess broad spectrum of biolog...

Partha Pratim Kaishap* and Chandrajit Dohutia

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh- 786004, Assam, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1312-22

1312-1322

2079

901

9.

IS EMERGENCY CONTRACEPTIVE ACCESSIBILITY A BARRIER IN DEVELOPING COUNTRIES? A REVIEW

Significant portion of maternal death in developing countries was attributed to induced abortions secondary to unwanted pregnancies.  Using emergency contraception as a backup method can contribute to reduce unwanted pregnancy secondary to method failure, contraception non-use and also rape. The need for emergency contraception is clearly demonstrated by the occurrence of unwanted pregnancy and i...

Zewdneh Shewamene *, Befikadu Legesse and Zelalem Eteffa

Lecturer, University of Gondar, Department of Pharmacology and Therapeutics, P.O.Box: 196, Gondar, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1323-25

1323-1325

1200

420

10.

CONTEMPORARY APPROACHES FOR BI-LAYER TECHNOLOGY OF DRUGS THROUGH ORAL ROUTE: AN OVERVIEW

Bi-layer tablet technology for bimodal release of drug and co-administration of drugs via oral route has been engaged a significant place in the field of drug delivery technology. At present, several pharmaceutical companies are developing bilayer tablet for co-administration of drugs to improve the therapeutic efficacy as well as to reduce the chances of drug-drug interaction. This review indicat...

Rishikesh*, Mohiuddin Ahmed Bhuiyan, S. M. Ashraful Islam, Irin Dewan, Md. Asraful Islam and Md. Sium Ul Hossain Miah

Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1326-34

1326-1334

1908

526

11.

IMPACT OF VITAMINS IN PREVENTION OF RISK FACTORS ASSOCIATED WITH TYPE-2 DIABETES MELLITUS

Diabetes mellitus is one of the most common metabolic disorders that cause micro and macro vascular complications. Because of additive effects of hyperglycaemia and hyperlipidaemia for cardiovascular disease, serum lipid and glucose level should be closely monitored in diabetes. Chronic Hyperglycaemia resulting from diabetes has profound effects on nearly every system of the body. The toxic effect...

V.K. Gupta*, Asha Pathak , Manoj Gahlot , R.C. Verma and C.V. Singh

Department of Pharmacology, Uttar Pradesh Rural Institute of Medical Sciences & Research , Saifai, Etawah, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1335-47

1335-1347

1509

414

12.

NON-INVASIVE PRENATAL DIAGNOSIS: A REVIEW

Aneuploidies are one of the important causes of perinatal morbidity and mortality. Initially screening for aneuploidies started with maternal age risk estimation. Later on, serum testing for biochemical markers and ultrasound markers were added. Women detected to be at high risk for aneuploidies were offered invasive testing. Recently, various methods including non-invasive prenatal testing (NIPT)...

Madhusudan Dey, Sumita Agarwal and Sumedha Sharma

40/ 41, First floor, Momohar kunj, Gautam Nagar, New Delhi – 110049

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1348-55

1348-1355

1819

868

13.

EXPRESSION OF FULLY FUNCTIONAL GPCR IN E. COLI

One-third of eukaryotic proteins are associated with membranes and these membrane proteins (MP) represent approximately 50% of pharmacological targets. Researchers are therefore nursing the hope of achieving a higher percentage of about 80% in the near future. The only bottleneck to achieving this target is the experimental challengers associated with the production, purification and crystallizati...

D. O. Acheampong*, J. Zhang and M. Wang

Department of Molecular Biology, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1356-62

1356-1362

2201

535

Research Articles

 
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14.

ROLE OF THE PHARMACEUTICAL CARE IN THE MANAGEMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS

Objective: The study was designed to evaluate the efficiency of pharmaceutical care on the control of clinical parameters, such as fasting glycaemia and glycosylated haemoglobin also to assess drug therapy problems in patients with type 2 diabetes mellitus. Setting: the study was conducted at Diabetic Center in Sulaimany/Iraq, during 18 September 2010 -20 January 2011. Methods: A prospective an...

Taha O. Mahwi*and Kawa A. Obied *

Department of Clinical Pharmacy, School of Pharmacy, Sulaimani University, Kurdistan-Iraq

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1363-69

1363-1369

2653

629

15.

ANTIHYPERGLYCAEMIC ACTIVITY OF ETHANOLIC EXTRACT OF THE STEM OF ADENIA LOBATA ENGL (PASSIFLORACEAE)

Adenia lobata Engl (Passifloraceae) is a woody climber which grows in most African countries mainly the coastal belt. It is an important medicinal plant used to treat haemorrhoids, malaria, fever, diabetes and gonorrhea. In our attempt to find out the constituents of this medicinal plant, the dried stem powder of A. lobata was successively extracted by Soxhlet with petroleum ether and 70% ethanol ...

J.A. Sarkodie*, T.C. Fleischer , D.A. Edoh , R.A. Dickson , M.L.K. Mensah , K. Annan , E. Woode , G.A. Koffour , A.A. Appiah and H. Brew-Daniels

Head of Phytochemistry, Centre for Scientific Research Into Plant Medicine, P.O. Box 73, Mampong Akuapem, Ghana or Department of Pharmacognosy and Herbal Medicine, School of Pharmacy, University of Ghana, Legon.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1370-77

1370-1377

1446

461

16.

ASSESSMENT OF ANTIOXIDANT, CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT FRACTIONS OF CRUDE EXTRACT OF STEPHANIA JAPONICA STEM

The different fractions of crude methanolic extract of stem of Stephania japonica (Thunb.) Miers was evaluated for antioxidant, cytotoxic and antibacterial activities. The various fractions of S. japonica Stem i.e. Ethyl Acetate (EAJS), CHCl3 (CFJS), CCl4 (CTJS) and Petroleum ether (PEJS) were subjected to free radical scavenging activity. In this investigation, CFJS showed the most significant fr...

Bishwajit Bokshi , S.M. Abdur Rahman*, Samir Kumar Sadhu , Ashif Muhammad and Hemayet Hossain

Professor, Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1378-83

1378-1383

1159

504

17.

COMPARATIVE QUALITY EVALUATION OF SOME METRONIDAZOLE TABLETS AND METRONIDAZOLE BENZOATE ORAL SUSPENSIONS AVAILABLE IN RETAIL OUTLETS OF ADDIS ABABA, ETHIOPIA

In this study, five different products of each metronidazole tablets and benzoate salt oral suspensions were purchased from the different retail outlets in the local market of Addis Ababa and analyzed using official methods (Pharmacopoeial methods of USP/BP/IP) by employing HPLC for the tablet dosage forms and non-aqueous titration with potentiometric end point for the suspensions. The assay resul...

Wubayehu Kahaliw and Ayenew Ashenef*

Addis Ababa University, College of Health Sciences, School of Pharmacy, Department of Pharmaceutical Chemistry and Pharmacognosy, P.O. Box. 1176, Addis Ababa, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1384-91

1384-1391

4689

2404

18.

ANTIDIABETIC EFFECTS OF ACACIA TORTILIS SEED EXTRACT IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS

The concerned study reveals the first time experimental investigation of Hypoglycemic and antihyperglycemic effect of seed extract of Acacia tortilis plant was in normoglycaemic and Alloxan-induced (135 mg/Kg body weight intraperitoneally) diabetic rats. The seed extract at the dose of 100 and 200 mg/kg body weight was administered orally once a day for 13 days and at the end of the experimentatio...

Neeraj K. Agrawal*, Uma Gupta , Piyush Misra, S.P. Singh , Rakesh C. Verma

Senior Resident, Department of Pharmacology, Maulana Azad Medical College, Delhi University 1, New Delhi, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1392-97

1392-1397

1795

472

20.

EFFECT OF NATURAL AND SYNTHETIC POLYMER ON RELEASE OF KETOTIFEN FUMARATE MATRIX TABLETS: A SUSTAINED RELEASE DOSAGE FORM

With the blend of Methocel K15, a synthetic polymer and xanthan gum, a natural polymer (3:1) was used in the formulation of matrix tablets to find out the effect of natural polymer in the sustained release dosage form. Direct compression process was applied for the preparation of Ketotifen fumarate tablets. The dissolution profiles were carried out by USP apparatus 2 (paddle) at 50 rpm in 500 ml 0...

Md. Mofizur Rahman*, Abul Bashar Ripon Khalipha , Md. A. K. Azad , MD. ZAkaria Faruki , Amit K. Chaurasiya and Hemayet Hossain

Assistant Professor, Department of Pharmacy, Bangladesh University, Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1401-08

1401-1408

1620

666

21.

PHYTOCHEMICAL EVALUATION AND HPTLC PROFILING OF EXTRACTS OF SALACIA OBLONGA

Plants of medicinal importance though are quite well known among the Ayurvedic practitioners since years, yet many of them have not been standardized, validated and documented completely. Among such medicinally valuable plants, Salacia holds a place as an effective antidiabetic herb and many species of this plant are in use as anti-diabetics. The present study reports the phytochemical analysis of...

Sujata Basu, Mamta Pant and Rachana*

Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida – 201307, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1409-18

1409-1418

2045

988

22.

DEVELOPMENT AND VALIDATION OF UV METHOD OF TEMOZOLOMIDE IN BULK AND CAPSULE FORMULATION

An   UV   spectrophotometric   method   for   the quantitative   determination   of Temozolomide (TMZ) in bulk and capsule   was developed   in   present   work. The parameters linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to International   Conference   on Harmonization guidelines. UV spectroscopic determination wa...

A. Abdul Razak*, Sk. Masthanamma, B. Omshanthi, V. Suresh and P. Obulamma

Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1419-23

1419-1423

1929

671

23.

ANTICONVULSANT AND SEDATIVE EFFECTS OF LEAF EXTRACT OF SOLANUM PUBESCENS

The herbal preparation of the leaves of Solanum pubescens Pers (Solanaceae) is used in traditional medicine for the treatment of Epilepsy and febrile convulsions. A pilot study has confirmed the potency of the leaf of Solanum pubescens in the control of seizure in mice. The current study was aimed to identify the active phytochemical responsible for the activity. Results indicated that methanolic ...

A. Suvarchala Kiranmai, K. Hemamalini*, and Uma Vasireddy

Department of Pharmacology, Teegala Ram Reddy College of Pharmacy, Meerpet, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1424-27

1424-1427

1517

479

24.

ISOLATION AND CHARACTERIZATION OF BIOACTIVE ACTINOMYCETES FROM SOIL IN AND AROUND NAGPUR

ABSTRACT: Fifteen soil samples were collected from different locations near Nagpur i.e. from Nagpur, Bhandara and Chandrapur. Air drying and pre-treatment of soil samples with CaCo3 (1%) were found to be most effective for isolation of actinomycetes. Five different selective media were used for the isolation of actinomycetes and the best growth was observed in yeast malt extract agar medium with 1...

Rita N. Wadetwar* and Arun T. Patil

Assistant Professor, J. L. Chaturvedi College of Pharmacy, Electronic Zone Building, Hingna Road, Nagpur 440016, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1428-33

1428-1433

5216

1678

25.

STUDIES ON THE ANTI-INFLAMMATORY AND ANALGESIC EFFICACY OF SCINDAPSUS OFFICINALIS (ROXB.) SCHOTT IN LABORATORY ANIMALS

This research was focused on the qualitative and quantitative evaluation of anti-inflammatory and analgesic effects of ethanolic extract of Scindapsus officinalis (EESO) fruit in laboratory animals and whether these effects were of any statistical significance.  Carrageenan-induced Hind Paw Edema test in long evans rat was the experiment for anti-inflammatory activity of the ethanolic extract of ...

N. Ferdous* and S.U. Hridi

Department of Pharmacy, North South University, Plot -15, Block- B, Bashundhara R/A, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1434-41

1434-1441

1662

503

26.

AQUEOUS ROOT EXTRACT OF THE ANTIMALARIAL HERBAL CRYPTOLEPIS SANGUINOLENTA (LINDL.) SCHLTR DELAYS THE DEVELOPMENT OF PHYSICAL LANDMARKS AND SENSORIMOTOR SYSTEMS IN MICE

We demonstrated previously that the aqueous root extract of Cryptolepis sanguinolenta (cryptolepis), with cryptolepine as the major constituent adversely affect reproduction and foetal development in mice. However, very little is known on the effect of prenatal exposure of cryptolepis on the post-natal life of surviving animals.  Using murine models, we report here, the effects of prenatal exposu...

K.B. Mensah and C. Ansah*

Department of Pharmacology, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1442-48

1442-1448

1515

574

27.

ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF THE PLANT ERVATAMIA CORONARIA (STAPF.)

The present study was conducted to evaluate the analgesic and anti-inflammatory potential of the flowers of Ervatamia coronaria. The analgesic activity of the extract was assessed by the acetic acid induced writhing test.  Aspirin was used as a standard drug. The anti-inflammatory activity was evaluated by carrageenan induced rat hind paw edema method. The initial paw volume was measured plethysm...

Himanshu Joshi*, Arun B Joshi, D. Satyanarayana, M.P. Gururaja and C.S Shastry

Nitte Gulabhi Shetty Memorial Institute of Pharmaceutical Sciences, Paneer, Mangalore 575018, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1449-52

1449-1452

1556

447

28.

PREVENTION OF RADIATION INDUCED HEMATOLOGICAL ALTERATIONS IN MICE BY ALSTONIA SCHOLARIS EXTRACT

Backround: The present study has been carried out to evaluate the radio-protective effects of Alstonia scholaris extract (ASE) on peripheral blood of mice. Materials & Methods: Male Swiss albino mice were selected from an inbred colony and assorted into 4 groups. Animals in Group I were administered with double distilled water (DDW), volume equal to ASE, by oral gavage to serve as vehicle t...

Uma Gupta*and Neeraj K. Agrawal

701, Shanti Nagar,Durgapura Station, Jaipur-302018, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1453-59

1453-1459

1311

512

29.

SELF-MEDICATION AMONG DENTAL UNDERGRADUATE STUDENTS: A GROWING CONCERN

Background: Self-medication is an important component of self-care. Though it is widely practiced globally, very few studies have evaluated its pattern and prevalence in dental students. Aim: The study was conducted to compare pattern of self-medication practices between junior and senior dental undergraduate students. Methods: This was a cross-sectional, anonymous, descriptive study with a ...

Suruchi Aditya

Department of Pharmacology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Sector 25, Chandigarh (UT), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1460-65

1460-1465

2362

590

30.

PRELIMINARY ANTIMICROBIAL ACTIVITY AND CYTOTOXICITY OF PLANT EXTRACTS (ROOTS) OF COCCINIA GRANDIS (FAMILY: CUCURBITACEAE) h

In the present study, the in vitro antimicrobial and cytotoxic activity of root extract of Coccinia grandis were evaluated. Ethanolic crude extract with its various solvent soluble fractions of C. grandis showed significant antimicrobial activity by disc diffusion method on some gram positive and gram negative bacteria. The extracts exhibited 9-12 mm (approximately) of zone of inhibition comparing...

Md. Hasanuzzaman , Md. Shahadat Bin Sayeed , Md. Siddiqul Islam , Md. Shahid Sarwar , Md. Mizanur Rahman Moghal , Jami Uddin Ahmed and Mohammad Safiqul Islam*

Assistant Professor, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1466-68

1466-1468

1472

545

31.

RP-HPLC ANALYSIS OF METFORMIN HYDROCHLORIDE AND VOGLIBOSE AND STUDY OF ITS DIFFERENT ANALYTICAL PARAMETER

A simple, specific, precise, and efficient method for the Simultaneous estimation of Metformin HCl and Voglibose tablet by a Reverse Phase-High Performance Liquid Chromatography method is developed and validated. Selected mobile phase was in a combination of acetonitrile: buffer pH- 6.5 in the ratio of 62:38. Optimized column is a stainless steel column packed with base octa decylsilyl silica gel ...

K. Sonia* and K. Prasad babu

Department of Pharmaceutical Analysis, K.K College of Pharmacy, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1469-74

1469-1474

2095

665

32.

AN OPEN LABEL PILOT STUDY TESTING THE ROLE OF CLASSICAL HOMEOPATHY IN CHRONIC ALLERGIC RHINITIS

Purpose: The prevalence of allergic rhinitis (AR) is increasing at an alarming rate throughout the world.  India has an estimated number of 15-20 million patients with allergic bronchial asthma and 30-80% of these suffer from AR. So, AR is considered as a major chronic respiratory disease due to its prevalence, impact on quality of life (QoL), work/school performance and productivity, economic bu...

Shubhamoy Ghosh*, Satadal Das, Malay Mundle, Dishari Sengupta, Sk. Intaj Hossain, Munmun Koley and Subhranil Saha

Department of Pathology & Microbiology, Mahesh Bhattacharyya Homeopathic Medical College & Hospital, Government of West Bengal; Drainage Canal Road, Dumurjola, Howrah- 711104, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1475-84

1475-1484

2462

838

33.

IMMOBILIZATION OF TANNIN ACYL HYDROLASE FROM ASPERGILLUS NIGER

Tannin acyl hydrolase, commonly referred to as tannase (E.C. 3.1.1.20), an inducible extra-cellular enzyme produced by a number of animals, plants and microbes. In this investigation, tannase production under solid-state fermentation by using Aspergillus niger and the waste residue of cashew husk was used as substrate for obtaining the desired fermented product. After termination of fermentation g...

B. Lenin Kumar*, N. Lokeswari and D. Sriramireddy

Research Scholar, Department of Biotechnology, Dr. B.R. Ambedkar University, Etcherla, Srikakulam Dist., Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1485-87

1485-1487

1472

513

34.

CREATININE CLEARANCE AS A MARKER FOR DIAGNOSING THE SEVERITY OF PREECLEMPSIA

Background: For many years, creatinine clearance has become increasingly popular because of several advantages. The major error arises in clearance test when the timing of urine collection is inaccurate and the bladder is incompletely empty. Aim: In view of the aforementioned controversial literature, it was decided to evaluate the relation-ship between the renal changes (creatinine clearance) ...

Satya Prakash* and Neha Sharma

Department of Biochemistry, Shri Ram Murti Smarak Institute of Medical Sciences (SRMSIMS), Bareilly, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1488-94

1488-1494

3093

516

35.

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CHROMONES BEARING 1, 5-BENZO THIAZEPINYL MOIETY

1, 5-Benzothazepinyl chromones were synthesized starting from 2, 4-diacyl phenol. The 2, 4-diacyl phenol was condensed with aryl aldehydes to obtain bis-chalcones1a-d. The bis-chalcones on cyclocondensation with equimolar amount of 2-aminothiophenol gave 1, 5-benzothiazepinyl chalcones2a-d. The chalcones on oxidative cyclisation in DMSO - I2 yielded the titled compounds3a-d. The microbial evaluati...

R.V. Dengle*and R. N. Deshmukh

Associate Professor, Department of Chemistry, Vivekanand College, Kolhapur – 416002, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1495-98

1495-1498

1496

571

36.

IMPACT OF NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE ON C-REACTIVE PROTEIN IN OBSTRUCTIVE SLEEP APNEA PATIENTS

Obstructive sleep apnea (OSA) has been increasingly linked with cardiovascular risk factors. Mechanisms such as increased sympathetic activity and endothelial dysfunction have been implicated. There are many factors which are responsible for the cardiovascular morbidity in OSA patients they are Obesity, C-reactive protein (CRP) and lipid profile. To study the impact of nasal continuous positive ai...

Geetha Kandasamy* and Abhay Dharamsi

Research Scholar, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad - 500 085, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1499-03

1499-1503

1281

407

37.

OPTIMIZATION OF THE FORMULATION AND IN-VITRO EVALUATION OF CAPECITABINE NIOSOMES FOR THE TREATMENT OF COLON CANCER

The goal of the present study was to investigate the feasibility of using non-ionic surfactant vesicles as carriers for the sustained delivery of water soluble anti-cancer drug Capecitabine, used in the treatment of colorectal cancer. The niosomal formulations were prepared using various non-ionic surfactants (span 40, span 60, tween 40 and tween 60) in the presence of cholesterol, by thin film hy...

B. Anbarasan , S. Rekha, K. Elango , B. Shriya and S. Ramaprabhu*

Alternative Energy and Nanotechnology Laboratory, Nano functional Materials Technology Centre, Department of Physics, Indian Institute of Technology, IIT Madras, Chennai- 600036, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1504-13

1504-1513

2234

1103

38.

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF TELMISARTAN

The patients with sudden increase blood pressure have markedly reduced function ability and extremely restless, in such cases rapid onset of action is of prime importance. So the patients would be benefited from acute treatment by using Fast dissolving drug delivery system. Telmisartan is an Anti-hypertensive drug which is insoluble in water; hence the drug may be slowly or incompletely dissolves ...

Kapil Chauhan*, Bharat Parashar, Abhishek Chandel and Varun Thakur

Department of Pharmaceutics, Manav Bharti University, Village Laddo, Tehsil & Distt. Solan- 173229, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1514-20

1514-1520

3520

1212

39.

TESTING EFFICACY OF HERBAL DRUG “FORTEGE” IN TREATMENT OF METAL INDUCED INFERTILITY IN MALE MICE

Fertility was tested in 0.5 mM/kg b. wt. (i.p) Lanthanum chloride exposed mice. Beneficial effects of “Fortege” an ayurvedic medicine (Alarsin co. Bombay) were also tested. Lanthanum chloride affected sperm count and motility. Lanthanum chloride could have affected Sertoli cells adversely and that have reduced sperm’s ability of uptake of fructose and as a result of it sperms became unable t...

Mahesh Mishra* and Asha Mathur

Vijaya Raje Institute of Science and Management, Jiwaji University, Gwalior, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1521-23

1521-1523

1979

652

40.

SYNTHESIS, ANTIBACTERIAL ACTIVITY AND MOLECULAR PROPERTIES PREDICTION OF SOME PYRIDAZIN-3-ONE DERIVATIVES

We have synthesized some new pyridazine-3-one derivatives and characterized by means of IR, NMR & mass spectral data. Compounds were evaluated for in-vitro antibacterial activity by disc diffusion method and further subjected to molecular properties prediction and drug-likeness by Molinspiration software. All compounds were found in compliance with Lipinski ‘Rule of Five’ and presented a g...

Pankaj Budhlakoti , Y. Kumar , Amita Verma* and Shashi Alok

Head, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences-Deemed University, Allahabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1524-28

1524-1528

1337

622

41.

IMPACT OF SODIUM AND POTASSIUM IONS IN IDENTIFICATION OF OFFSPRING GENDER IN HAMSTERS

Impacts of sodium and potassium in diet to determine offspring gender in hamsters have been investigated. Sex determination has scientific basis for prevention of genetic diseases in addition to social backgrounds.20 healthy  hamsters chosen from the first generation of the previous experimental hamsters, were divided in to two groups in the hamsters male to female 1:5. The first group was Na and...

S. Chandraju*, Ashraf Beirami and C.S. Chidan Kumar

Department of Studies in Sugar Technology, Sir M. Vishweshwaraya Post-Graduate Center, University of Mysore, Tubinakere-571402, Mandya, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1529-33

1529-1533

2209

519

42.

ANTIBACTERIAL ACTIVITY OF COW URINE AGAINST SOME PATHOGENIC AND NON-PATHOGENIC BACTERIA

Cow urine therapy and all traditional practices from Indian systems of medicine have a strong scientific base. The cow has proved to be a boon in the areas of agriculture, science and technology, industry, energy, medicine etc for the development of any nation, in addition being eco-friendly in nature. In the present study the antibacterial potentials of cow urine were investigated. Total 14 patho...

S. Raad , D.V. Deshmukh*, S. N. Harke and M.S. Kachole

Assistant Professor, MGM’s, Institute of Biosciences and Technology, N-6, CIDCO, Aurangabad, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1534-39

1534-1539

5132

1017

43.

STUDIES ON ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF OYSTER MUSHROOM PLEUROTUS FLORIDA

The antimicrobial and antioxidant activity of four different solvent extracts of P. florida were investigated. The antimicrobial activities of different solvents were tested against different bacteria and fungi using disc diffusion method. Total antioxidant, reducing power and total phenolic content effect of the extracts was determined by phosphomolybdenum assay, 2,2-diphenyl-1-picrylhydrazyl (DP...

K. A. Thillaimaharani , K. Sharmila , P.Thangaraju , M. Karthick and M. Kalaiselvam*

Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai- 608 502, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1540-45

1540-1545

3846

1404

44.

CAMELLIA SINENSIS LEAVES A NEW TREATMENT AGAINST URINARY TRACT INFECTION CAUSED BY PSEUDOMONAS FLUORESCENS AND SERRATIA SP

Urinary tract infection is the most common disease in females and males which is big threat of kidney failure. The increasing interest is in the powerful biological activity of medicinal plant containing bioactive compounds which paves way for the importance to determine their antibacterial activity. The bioactive chemical determination revealed the presence of bioactive constituents’ steroids, ...

A.L. Tariq* and A.L. Reyaz

Department of Microbiology, Sree Amman Arts and Science College, Erode-638102, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1546-50

1546-1550

1642

615

45.

PHYTOCHEMICALS INVESTIGATION AND TLC PROFILING OF CYAMOPSIS TETRAGONOLOBA L. SEEDS (FABACEAE) – PEA FAMILY

Cyamopsis tetragonoloba L. is belongs to the family Fabaceae. It is used as herbal and as vegetable from ancient times. It is abundant in tropical region of Africa and Asia. Preliminary phytochemicals investigations have been carried out on the seed extract using n-Hexane, Ethyl Acetate, Acetone, Ethanol and Methanol solvents. Qualitative phytochemicals analysis reflects the presence of Phenol, ...

Sunil H. Ganatra*, Archana M. Ramteke, Shweta P. Durge and S.U. Patil

Department of Chemistry, Government Institute of Science, Nagpur (Affiliated to Rashtrasant Tukdoji Maharaj Nagpur University), Nagpur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1551-55

1551-1555

1904

1417

46.

IN VITRO ANTIBACTERIAL ACTIVITY AND CALLUOGENESIS OF BRYONIA LACINIOSA

Interest in medicinal plant as a re-emerging health aid has been fuelled by the rising cost of prescription drug in the maintenance of personal health. In present work an attempt has been made to carry out antimicrobial activity of bryonia laciniosa plant, used in Indian folk medicine. The aim of the study was to grow in vitro callus from bryonia laciniosa from leaf explants and its microbial acti...

Ujjwala Supe

Plant Tissue Culture Laboratory, Department of Biotechnology, St. Thomas College, Bhilai, Dist-Durg- 490006, Chhattisgarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1556-60

1556-1560

1485

746

47.

FACTORS AFFECTING VASECTOMY ACCEPTABILITY IN ETHIOPIA

Vasectomy is one of the most effective but less utilized types of contraception method which could addresses the involvement of males to the family planning. The aim of the study was therefore to investigate the awareness about and practice of men towards vasectomy among workers in Dashen brewery, Ethiopia. Descriptive cross sectional study was conducted using pre tested self-administered question...

Edmealem Admasu , Negalign chekol , Temesegen Chekol , Zewdneh Shewamene*, Zelalem Eteffa

Department of Pharmacology and Therapeutics, University of Gondar 4, P.O.Box: 196, Gondar, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1561-64

1561-1564

1938

474

48.

PSYCHOLOGICAL EFFECTS OF USING POWER-ENHANCING DRUGS ON GYM-EXERCISING INDIVIDUALS

Exercising in a gym, largely aimed at getting a better-shaped body, is a long and tiring process. So many people opt for power enhancing drugs, boosting their athletic performance. These include steroids, erythropoietin, creatine, protein and zinc supplements among others. Together with increasing the muscle bulk, they exert highly undesirable effects on normal physiology. The subjects were asked ...

Faizan Mirza*and Sadaf Ahmed

Department of Physiology, University of Karachi, Karachi, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1565-68

1565-1568

1626

555

49.

IMPROVEMENT OF SOLUBILITY OF BADLY WATER SOLUBLE DRUG (IBUPROFEN) BY USING SURFACTANTS AND CARRIERS

Although there was a great interest in solid dispersion systems during the past four decades to increase dissolution rate and bioavailability of badly water-soluble drugs, their profitable use has been very limited, primarily because of manufacturing difficulties and stability problems. In this study solid solutions of drugs were generally produced by fusion method. The drug along with the excipie...

Md. Zakaria Faruki*, Rishikesh, Elizabeth Razzaque, Mohiuddin Ahmed Bhuiyan

Department of Pharmacy, University of Asia Pacific, Dhaka-1209, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1569-74

1569-1574

6448

817

50.

LEAD TOXICITY AND POSTNATAL DEVELOPMENT OF OVARY

Purpose: The course of human development from conception to adulthood is extremely complex. The developing organism is particularly vulnerable to toxic insult because of rapid cell division and differentiation and severely affected during gestation and lactation. The aim of the present study was to evaluate lead toxicity on the female reproductive system during neonatal period. Methods: Histopa...

Ragini Sharma, Khushbu Panwar*, Isha Barber and Amit Purohit

Environmental and Developmental Toxicology Research Laboratory, Department of Zoology, University College of Science, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1575-84

1575-1584

1863

568

51.

ASSESMENT OF CYTOTOXIC EFFECT OF METHANOLIC CRUDE EXTRACTS OF AZADIRACTA INDICA

The aim of the research is to observe the cytotoxic activity of methanolic crude extracts of Azadirachta indica, a plant belonging to the family Meliaceae. The root of Azadirachta indica was extracted with organic solvent and the extracts were fractionated by using three fractions (n-hexane, ethyl acetate and chloroform). The crude extracts were screened for antitumor properties using brine shrimp...

Md. Mahabubul Alam Rakib and Mohammad Musarraf Hussain*

Assistant Professor, Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1585-90

1585-1590

1492

421

52.

AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECTS OF AEGLE MARMELOS AND IT’S COMPARISON WITH PIRACETAM ON LEARNING AND MEMORY IN WISTAR RATS

Present study was done to evaluate the memory enhancing effect of Aegle marmelos and its comparison with the present standard treatment Piracetam in Wistar rats. The learning and memory was assessed using the elevated plus maze. The  findings of the present study indicate that, Aegle marmelos extract treated animals at a dose of 100 mg/kg p.o. as well as 200 mg/kg p.o. showed significant decrease...

Himani , Shankar Pratap , R. C. Verma*, Sharad Leve , Amod Sachan and R.K. Dixit

Lecturer, Department of Pharmacology, R.I.M.S, Safai, Etawah, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1591-97

1591-1597

1577

563

53.

HEPATOPROTECTIVE ACTIVITY OF SCINDAPSUS OFFICINALIS FRUIT IN PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

Scindapsus officinalis (Roxb.) Schott fruits are widely used in many parts of India for the treatment of various diseases. It is one of the plants used in Indian system of medicine which belongs to family Aracea. It has the significant antioxidant property due to presence of flavonoids and phenolic compound and has ability of cytoprotection due to antioxidant property. Hydroalcoholic extract (50%E...

Nikhil Shrivastava*, Preeti Agrawal , Akanksha Khare , Sarlesh Rajput , Rajendra Singh Baghel , Satyendra Singh Baghel

Department of Pharmacology (Toxicology Research Division), Shriram College of Pharmacy, S.R.G.O.C. Campus, AB Expressway Banmore, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1598-09

1598-1609

1673

822

54.

SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CLOMIPRAMINE IN BULK AND TABLET DOSAGE FORM

A simple and sensitive spectrophotometric method has been developed for the determination of Clomipramine in bulk and tablet dosage forms. The method was based on the charge transfer reactions of Clomipramine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone. The absorbance of the highly intensive coloured solution was measured at 470 nm against reagent blank treated similarly. Beer’s law is obey...

Aitha Vijaya Lakshmi

Department of Chemistry, Sri Krishnadevaraya University, Kurnool – 518 001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1610-13

1610-1613

1542

628

55.

DESIGN AND EVALUATION OF SUSTAINED RELEASE MULTIPARTICULATE SYSTEM OF TIZANIDINE HYDROCHLORIDE

The aim of the present investigation is to formulate and evaluate Tizanidine hydrochloride sustained release pellets. Tizanidine hydrochloride is an immadazole α2-adrenergic agonist used in the management of increase in muscle tone associated with spasticity. It has short biological half-life of 2- 2.5 hrs and is rapidly eliminated from the body. Sustained release dosage form of Tizanidine hydroc...

M. Thriveni , A. Brahma Reddy , D. Srinivas Reddy , D. Vasavi Reddy

Department of Pharmaceutics, Vaageswari College of Pharmacy, Beside L.M.D Police Station, Thimmapur, Karimnagar Dist., 505481, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1614-25

1614-1625

2092

621

56.

PROXIMATE, PHYTOCHEMICAL PROFILE AND ANTIOXIDANT ACTIVITY (IN VITRO AND EX VIVO) OF MORUS INDICA VARIETIES

Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the...

Vanitha P. Reddy and Asna Urooj*

Department of Studies in Food Science and Nutrition, University of Mysore, Mysore-570006, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1626-34

1626-1634

1765

687

57.

IN-SILICO ADMET PREDICTION OF PHYTOCHEMICALS IN CAMELLIA SINENSIS AND CITRUS SINENSIS

Camellia sinensis and Citrus sinensis are treasuries of medicinal properties. The compounds present in these plants can deliver potential therapeutic drug. Most of the drugs in clinical development fail to commercialize because of poor ADME and toxicity properties.  The main aim of the study is pharmacokinetic investigation and toxicity property, the most causes of high attrition rates in drug de...

V. Sathya* and V.K. Gopalakrishnan

Department of Bioinformatics, Karpagam University, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1635-37

1635-1637

1817

609