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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 5 (2014) - Issue 11, November

Review Articles

 
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1.

OXAZOLINES: THEIR SYNTHESIS AND BIOLOGICAL ACTIVITY

Heterocylic chemistry have been known for many years but in recent years heteocyclics received great attention. In heterocyclic chemistry oxazoline is one of the most important moiety. Oxazoline moiety shows a wide range of application such as in agriculture industry, pharmaceutical, food industry, natural product, medicine, polymers and various other industries. Oxazoline moiety constitutes the c...

Shivani Bansal and A. K. Halve*

School of Studies in Chemistry, Jiwaji University, Gwalior, M.P., India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4601-16

4601-4616

5700

2105

2.

A REVIEW ON BIOCHEMICAL AND THERAPEUTIC ASPECTS OF GLUTAMINASE

One of the prime candidates in the treatment of debilitating human cancers includes a family of enzymes referred to as L- glutaminases. The antitumor activity of these enzymes found effective in countering Acute Lymphoblastic Leukemia (ALL a commonly diagnosed pediatric cancer.). Further it is found to inhibit four human tumour cell lines namely Hep-G2 [Human hepatocellular carcinoma cell line], M...

Rahamat Unissa *, M. Sudhakar, A. Sunil Kumar Reddy and K. Naga Sravanthi.

Assistant Professor, Malla Reddy College Of Pharmacy, Maisammaguda, Dhulpally, Secunderabad, Hyderabad. India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4617-34

4617-4634

3140

1442

3.

SIGNIFICANCE OF PHARMACEUTICAL FACTORS ON SELECTION OF BIOBATCH

Biobatch is usually prepared for the purpose of pharmacokinetic evaluation before NDA or IND filing. There are several critical issues that one has to face during the audit process like equivalence between the Biobatch and proposed commercial production batch. During the development and scale-up of the manufacturing process, various standard operating processes have to be documented to provide lin...

Jayshil A. Bhatt and Ramesh K. Goyal*

Institute of Life Sciences, Ahmadabad University, Ahmadabad 380009, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4635-43

4635-4643

3040

5787

4.

STEREOCHEMISTRY AND ITS ROLE IN DRUG DESIGN

When designing small molecules to interact with the targets, one should consider stereo selectivity. As considerations for exploring structure space evolve, chirality is increasingly important. Binding affinity for a chiral drug can differ for diastereomers and between enantiomers. For the virtual screening and computational design stage of drug development, this problem can be compounded by incom...

Kuldeep Singh *, Pragati Shakya , Arun Kumar , Shashi Alok , Mehnaz Kamal and Satya Praksh Singh

Faculty of pharmacy, Integral University, Dasauli, P.O. Basha, Kursi road, Lucknow, Uttar Pradesh. India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4644-59

4644-4659

28447

2230

Research Articles

 
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5.

PREPARATION AND DRUG RELEASE BEHAVIORS OF pH-SENSITIVE MICROCAPSULES

The pH-sensitive microcapsules were prepared by interfacial polymerization, in which caffeine was used as a modeldrug and hyperbranched poly L-lysine (HBPL) and terephthaloyl chloride as wall-forming materials. The microcapsules were characterized by Malvern particle size analysis, scanning electron microscopy, Fourier transform infrared spectrophotometry (FTIR) and UV-vis spectrophotometer. Trito...

Puying An *, Shengbo Dou and Zhaoyun Yu

College of Basic Medical Science, Hebei University, No. 342, YuHua Road, Baoding, 071002, PR China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4660-65

4660-4665

1822

642

6.

QUALITY BY DESIGN IN THE DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD BY ULTRAVIOLET-VISIBLE SPECTROPHOTOMETRY FOR QUANTIFICATION OF HYDROXYCHLOROQUINE SULFATE

Developed originally as an antimalarial agent, the hydroxychloroquine sulfate (HCQ) is often used as a slow-acting anti-rheumatic drug in treating of disorders of connective tissue. The methods of quantification of HCQ sulfate, despite the undeniable advantages, have certain limitations, such as: high cost of operation and maintenance of equipment, sample processing and analysis of the results rel...

Leslie R. M. Ferraz *, Fabiana L. A. Santos , Pablo A. Ferreira, Ricardo T. L. Maia-Junior , Talita A. Rosa , Salvana P. M. Costa , Cybelly M. Melo , Larissa A. Rolim , Pedro J. Rolim-Neto

Laboratório de Tecnologia dos Medicamentos – Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Rua Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521 Recife - PE, Brazil.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4666-76

4666-4676

2110

1198

7.

IN-VITRO AND IN-VIVO EVALUATION OF NIOSOMES CONTAINING CELECOXIB

Niosomes as a vesicular system are well documented for delivering drugs, in controlled manner to enhance bioavailability and get better therapeutic effect over a longer period of time. Celecoxib is a NSAID, selective COX-2 inhibitor, which is used for treatment of rheumatoid arthritis, osteoarthritis and acute pain. The present study dealt with the preparation and characterization of celecoxib nio...

M.S. El-Ridy *, A.A. Abd ElRahman , G.M. AwadR.M. Khalil and M.M. Younis

National Research Centre, Albuhouth st., Dokki, Cairo 12311, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4677-88

4677-4688

1873

690

8.

IN VITRO COMPARATIVE COAGULATION STUDIES OF NOVEL BIODEGRADABLE N, O-CARBOXYMETHYLCHITOSAN (NO-CMC) AND OLIGO-CHITOSAN (O-C)

Naturally obtained chitosan biopolymers are increasingly being formulated as bioadhesives due to their hemostatic properties. Comparative studies have been conducted to measure hemostatic capacity of biodegradable 7% N,O-carboxymetylchitosan (NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, oligo-chitosan (O-C) and oligo-chitosan 53 (O-C 53).Biodegradability (loss of mass) of these chitosans in phospha...

Mercy Halleluyah Periayah, Ahmad Sukari Halim *, Nik Soriani Yaacob , Arman aharil Mat Saad , Abdul Rahim Hussein , Ahmad Hazri Abdul Rashid and Zanariah Ujang

Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4689-98

4689-4698

1560

582

9.

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS BY USING NATURAL POLYMER

The study was aimed at developing mucoadhesive buccal tablet containing Carvedilol. The effect of two independent variables, Casein (X1) and hydroxypropylmethyl cellulose (HPMC K4M) (X2) at  three different levels (-1, 0, +1) on dependent variable including hardness (Y1), cumulative percentage drug release at 6 hrs (Y2) and 12 hrs (Y3) using  32 full factorial design. FTIR and DSC results showed...

Anna Balaji, Vaddepalli Radhika* and Vishnuvardhan goud

Centre for Biopharmaceutics and Pharmacokinetics, Trinity College of Pharmaceutical Sciences, Peddapally, Karimnagar – 505172, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4699-08

4699-4708

4354

867

10.

ZYGOPHYLLUM GAETULUM AQUEOUS EXTRACT PROTECTS AGAINST DIABETIC DYSLIPIDEMIA AND ATTENUATES LIVER AND KIDNEY OXIDATIVE DAMAGE IN STREPTOZOTOCIN INDUCED-DIABETIC RATS

Zygophyllum gaetulum are one of several traditional remedies used for diabetes treatment in Algeria. The purpose of this study is to investigate the effects of this plant on hyperglycemia, insulin sensitivity indexes, lipid profiles, lecithin: cholesterol acyltransferase (LCAT) and paraoxonase (PON1) activities and liver and kidney antioxidant status, in streptozotocin-induced diabetic rat. Diabet...

A. Guenzet, D. Krouf *, S. Zennaki and S. Berzou

Laboratory of Clinical and Metabolic Nutrition, Department of Biology, Faculty of Natural and Life Sciences, University of Oran, Oran, Algeria.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4709-17

4709-4717

1631

638

11.

SYNTHESIS AND SPECTROSCOPIC STUDIES OF COBALT (II) COMPLEXES WITH NITROGEN- OXYGEN AND NITROGEN SULPHUR DONOR LIGANDS

CoII complexes of ligands pyridine3carboxamide thiosemicarbazone (L1), pyridine 3 carboxamide semicarbazone (L2), pyridine2carboxamide thiosemicarbazone (L3) and pyridine 2 carboxamide semicarbazone (L4) have been synthesised. The ligands were characterised on the basis of elemental analyses, IR, 1HNMR studies while the complexes were characterised by elemental analyses, molar conductance, magneti...

Sulekh Chandra*, Smriti Raizada and Sangeeta Sadwal

Department of Chemistry, Zakir Husain Delhi College, University of Delhi, Jawaharlal Nehru Marg, New Delhi 110002, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4718-23

4718-4723

1343

473

12.

EFFECT OF ELYTRARIA ACAULIS EXTRACTS ON FERTILITY IN MALE ALBINO RATS

Surgeries like vasectomy, tubectomy and medication (contraception) for the population control are not fully restraining the population growth.  Medicine available to control birth rate carrying side effects. The attempt of exploring the importance of Ayurveda the present work was carried out. The methanol extract of the plant Elytraria acualis was prepared by maceration technique. Extract effects...

G. V. R. Reddy *, R. V. Kumar and M. K. Reddy

Reproductive Physiology Unit, Department of Zoology, Kakatiya University, Warangal.-506009, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4724-27

4724-4727

1442

747

13.

DEVELOPMENT AND CHARACTERIZATION OF ORAL DISSOLVING FILM FOR PROMETHAZINE HCL

Promethazine hydrochloride, one of the most effective agents for treating motion sickness, mainly acts as a strong antagonist of the H1 receptor (antihistamine) and it blocks the action of acetylcholine on the receptors (anticholinergic effect). The purpose of present work was a development of fast dissolving oral film of promethazine HCL to overcome the limitation of current routes of administrat...

Dasharath M. Patel* and Dharmendrasinh V. Dabhi

Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Mehsana - 384001, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4728-40

4728-4740

2299

697

14.

ASSESSMENT AND EVALUATION OF HEXACHLOROCYCLOHEXANE (HCH) AND DICHLORODIPHENYLTRICHLOROETHANE (DDT) RESIDUES AND EXTENT OF DNA DAMAGE IN CATTLE OF KASARGOD DISTRICT, NORTHERN KERALA, INDIA

Pesticide uses pose a serious threat to environment and public health owing to their persistency and tendency to accumulate in animal and plant tissues. The present investigation was conducted to analyze pesticide residues mainly HCH and DDT in field and biological samples from the plantation areas of Northern Kerala, India and the extent of DNA damage in cattle was measured. Environmental samples...

Vijayakumar Dineshkumar *, Ponnusamy Logeswari , A. R. Nisha and P.T.A. Usha

Department of Toxicology, Vivo Bio Tech Private Limited, Pregnapur Village, Gajwel Mandal, Medak District, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4741-50

4741-4750

1551

827

15.

HEPATOPROTECTIVE POTENTIAL OF YOUNG LEAVES OF TRITICUM AESTIVUM LINN. AGAINST CCl4 INDUCED HEPATOTOXICITY

The plant selected for the activity is obtained from the ninth day young leaves ofTriticumaestivum Linn. belonging to the family Poaceae. The plant is commonly known as Wheatgrass which is used for various medicinal and health benefits for many years. It is considered as a cleansing and purifying agent from ancient times and yet can be used for its healing properties because of its nutritional val...

G. Jain*and A. Argal

Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajasthan, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4751-55

4751-4755

1557

639

16.

ANTIMICROBIAL POTENTIAL OF ACACIA NILOTICA EXTRACTS ON FEW DENTAL PATHOGENS

The acute dental abscess is frequently underestimated in terms of its morbidity and mortality. The risk of potential serious consequences arising from the spread of a dental abscess is still relevant today with many hospital admissions for dental sepsis. Acacia nilotica commonly known in India as Babul has wide range of medicinal uses. In the present study antibacterial activity of different parts...

Mukesh Pote * and Pradip Hirapure

Technical officer) State Reference Laboratory, Dept. of Pathology, S.R.T.R. Medical College Ambajogai. (Maharashtra), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4756-59

4756-4759

1972

543

17.

OPTIMIZATION STUDIES FOR ENHANCED BIOACTIVE METABOLITE PRODUCTION BY STREPTOMYCES VIOLACEORUBER VLK-4 ISOLATED FROM THE SOUTH COAST OF ANDHRA PRADESH, INDIA

The aim of the present study was to design the suitable culture medium and also optimize the culture conditions for enhanced production of antimicrobial metabolites by Streptomyces violaceoruber VLK-4 which exhibited a broad spectrum ofactivity against bacteria and fungi. Production of bioactive metabolites by the strain was high in modified yeast extract-malt extract dextrose (ISP-2) broth as com...

Krishna Naragani, Rajesh kumar Munaganti and Vijayalakshmi Muvva*

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur-522510. Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4760-68

4760-4768

1688

594

18.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF CEFPODOXIME PROXETIL

A new simple and rapid reverse phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous estimation of cefpodoxime proxetil in bulk drugs and pharmaceutical dosage form. The separation was accomplished on a sunfire C-18 (250x 4.6 mm, 5 μm) column with a mobile phase consisting of Methanol; Water (70:30 v/v) at a flow rate of 0.8 mL/min. The e...

Deepshikha Patle and Ambadas Rangnath Rote *

Department of Pharmacy Sardar Patel College of Technology, Balaghat M.P. 481001, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4769-73

4769-4773

2342

552

19.

ETODOLAC DISSOLUTION IMPROVEMENT BY PREPARATION OF SOLID DISPERSIONS WITH CYCLODEXTRIN COMPLEX’S

Etodolac is an anti-inflammatory drug that is poorly soluble in water.  This paper describes an approach to improve the dissolution rate of Etodolac by using solid dispersions (SDs) in hydrophilic polymers. The solid dispersions prepared with a Co-evaporation, kneaded method & Physical Mixture method using different concentrations of α-cyclodextrin (α-CD). The release of Etodolac from vario...

Rohini Pilli*, M.V. Nagabhushanam and SDVS Kiran Kadali

Assisstant Professor, Department of Pharmaceutics, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4774-91

4774-4791

2613

858

20.

VOLTAMMETRIC DETERMINATION OF RUPATADINE AT GRAPHENE MODIFIED GLASSY CARBON ELECTRODE

Electrochemical behavior of rupatadine, an anti-allergic drug was studied at graphene modified glassy carbon electrode in Britton-Robinson buffer (pH 6.5) by square wave voltammetry (frequency, 50 Hz; amplitude, 0.02 V; step potential, 0.005 V) and cyclic voltammetry (scan rates, 20-100 mV/s) techniques. Cyclic voltammetry revealed the oxidation of rupatadine corresponding to N-dealkylation which ...

H. Devnani *, P. Singh, S. Saxena and S. P. Satsangee

University Science Instrumentation Centre, Dayalbagh Educational Institute, Dayalbagh, Agra (U.P.) -282005 India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4792-99

4792-4799

1765

595

21.

ACUTE AND 28-DAY REPEATED DOSE TOXICITY OF AVERRHOA CARAMBOLA LEAVES ETHANOLIC EXTRACT IN RODENTS

Averrhoa carambola -L. (Oxalidaceae) has great importance in the Indian traditional system of medicine for controlling diabetes and piles: the combined extracts of leaves as well as fruits of A. carambola are used for the treatment of jaundice, gastric problems and other chronic conditions as well as in food supplements.The objective underlying this experiment is to determine the safety profile of...

Sandipan Mazumder * and Manash Pratim Pathak

Department of Pharmaceutical Sciences, Assam University Silchar Silchar, Assam- 788011, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4800-07

4800-4807

1761

476

22.

A NOVEL SPECTROFLUORIMETRIC METHOD FOR THE DETERMINATION OF MEMANTINE HYDROCLORIDE IN BULK AND PHARMACEUTICAL FORMULATION

The author selected and developed a new simple, sensitive and reproducible spectrofluorimetric method and validated for the determination of Memantine Hydrochloride in bulk as well as pharmaceutical formulations depending on condensation of  Memantine hydrochloride with 1, 2 - Naphthoquinone -4- sulphonate (NQS) in an alkaline medium to become a product with orange color.  The spectrofluorimetri...

P. Ravisankar *, G. Devala Rao and Ch. Devadasu

Associate Professor Department of Pharmaceutical Analysis and Quality Assurance, Vignan Pharmacy College, Vadlamudi-522 213, A.P., India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4808-14

4808-4814

1858

668

23.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF CINNARIZINE AND DIMENHYDRINATE IN TABLET DOSAGE FORM

A simple, rapid and precise reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of Cinnarizine and Dimenhydrinate in Tablet Dosage Form. Chromatography was performed on a PhenomenexPartisil ODS C18 (250 X 4.6 mm) 5mm column using Acetonitrile: Water (90:10) as a mobile phase. The detection of the synthetic mixture was carried out at 265 nm wi...

S. Khushbu and P. Pinkal

Department of Quality Assurance Parul Institute of Pharmacy and Research, Parul Trust Limda, Ta. Waghodia, Dist. Vadodara 391760, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4815-19

4815-4819

2632

1377

24.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MIGLITOL AND METFORMIN HYDROCHLORIDE IN TABLET DOSAGE FORM.

A simple, rapid and precise stability indicating reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of Miglitol and Metformine Hydrochloride in their tablet dosage form. Chromatography was performed on a Phenomenex ODS C18 (250 X 4.6 mm) 5mm column using Water: Methanol (50:50, v/v) pH: 4 mixture as a mobile phase. The detection was carried ...

P. Nilam *, P. Pinkal and S. Khushbu

Department of Quality Assurance, Parul Institute of Pharmacy and Research, Parul Trust Limda, Ta. Waghodia, Dist. Vadodara 391760, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4820-24

4820-4824

3081

553

25.

ANTIMYCOBACTERIAL ACTIVITY OF FOLIOSE LICHENS ON PLANT AND ANIMAL PATHOGENS

Antimicrobial effects of different extracts of lichens were evaluated in this study. Acetone extract of Heterodermia boryi have shown maximum inhibitory activity against Escherichia coli (22mm) followed by Staphylococcus aureus (21mm)and Pseudomonas fluorescenes (20 mm). Among fungi, diethyl ether extract gave desirable sensitivity pattern against Pestalotia foedans was very sensitive (21mm) follo...

M. Balasubramanian*and P. Nirmala

Department of Biotechnology, Kongu Arts and Science College, Nanjanapuram, Erode District-638107, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4825-31

4825-4831

1547

585

26.

ISOLATION OF ACTIVE COMPOUNDS FROM HYDRO ALCOHOLIC EXTRACT OF CARDIOSPERMUM HALICACABUM LINN

The uses of plant medicines are very common in Asia and developing countries. Phytochemicals has been used to treat chronic as well as infectious diseases. Cardiospermum halicacabum Linn. (Sapindaceae) is an herbaceous climber, commonly found throughout India, used as vegetable as well as traditional medicine for rheumatism, lumbago and nervous diseases. Many pharmacological studies have been done...

R. Rajeswari and M. Sriidevi *

Assistant Professor, Department of Biotechnology, Vinayaka Missions Engineering college, Vinayaka Missions University, Periyaseeragapadi – 636301, Salem, Tamilnadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4832-37

4832-4837

2563

595

27.

SENSITIVE AND SELECTIVE METHODS FOR DETERMINATION OF PROTEOLYTIC ACTIVITY OF FORMULATION CONTAINING BROMELAIN AND TRYPSIN AS PROTEOLYTIC ENZYMES

Accurate and sensitive assay methods for quantitative determination of Rutoside trihydrate (rutin), Trypsin and Bromelain in tablet formulation based on UV-spectrophometric analysis were developed and validated. This three drug combination has anti-inflammatory properties and hence is used for treatment of edema and inflammations. Rutin was analyzed directly by UV-Vis spectrophotometer at 257nm be...

S. S. Wani and R. C. Mashru*

Pharmacy Department, Faculty of Technology and Engineering, The M.S. University of Baroda, Near Dandia Bazar, Kalabhavan, Vadodara-390001, Gujarat state, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4838-45

4838-4845

2268

4437

28.

ANTIOXIDANT ACTIVITY OF GOAT LIVER SLICES TREATED WITH CUCUMIS MELO (L). FRUIT EXTRACT

 Plant derived natural products such as flavonoids, terpenes, alkaloids and polysaccharides have received considerable attention in recent years due to diverse pharmacological properties including cytotoxic and cancer chemo preventive effects. From a long period of time medicinal plants or their secondary metabolites have been directly or indirectly playing an important role in the human society ...

R. Vidya *, K. Kalaivani and R. Venkatesh

Department of Biochemistry, Kongunadu Arts and Science College (Autonomous), Coimbatore, Tamil Nadu - 641029, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4846-50

4846-4850

2164

659

29.

EVALUATION OF ANTI – CANCER ACTIVITY OF BARK OF CRATAEVA NURVALA BUCH. HAM AGAINST THREE CELL LINES

The present study was aimed to evaluate in-vitro anti-cancer activity of ethanolic extract of Crataeva nurvala Buch. Ham. The method used for determining the anticancer activity was the MTT bio-assay using A549(Human Lung Carcinoma) cell line, Hela (Human Cervix)cell line and MDA-MB(Human Adenocarcinoma, Mammary Gland)cell line. The ethanolic extract of Crataeva nurvala bark at different concentra...

N.S. Wagh* and N. J. Gaikwad

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati road, Nagpur- 440033, Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4851-57

4851-4857

1662

748

30.

A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN AND PRASUGREL IN TABLET DOSAGE FORM

Aim of the present work is to develop a rapid, simple, precise, accurate and reproducible reverse phase high performance liquid chromatographic method for simultaneous determination of Aspirin and Prasugrel in tablet dosage form. The estimation was carried out on a HIBAR (Lichrospher C-18) column with the dimensions of 250mm x 4.6mm, 5µm. Combination of Acetonitrile and 0.5% Potassium dihydrogen ...

P. Vivek Sagar *, T. Samidha , M. Vamshi Krishna and S. Shobha Rani

Care College of Pharmacy Oglapur (v), Atmakur (M), Warangal, Telangana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4858-64

4858-4864

2312

584

31.

DESIGN, SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2-{[(2E)-3-(3, 4, 5-MONO/DI/TRI HYDROXYPHENYL) PROP-2-ENOYL] SULFANYL/AMINO} PROPANOIC ACIDS IN HUMAN PLASMA BY ROTOR GENE-Q (5 PLEX) REAL TIME PCR METHOD

Halfmer of chicoric acid derivatives in two series were planned to synthesized and evaluated for their capacity to reduce the viral load in the human plasma by ROTOR GENE-Q (5 Plex) Real Time PCR method to check their biological activity. Different substituted hydroxy cinnamic acids has been conjugated with different amino acid in N-series and in K-Series same substituted hydroxy cinnamic acids ha...

Nadim M. R. Chhipa ⃰ and Dhrubo Jyoti Sen

Postgraduate Research Laboratory, Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4865-75

4865-4875

1723

566

32.

ANTIMICROBIAL ACTIVITY OF ESSENTIAL OILS AGAINST FOOD-BORNE PATHOGENIC BACTERIA

The increasing resistance of microbes to conventional drugs has promoted the scientists to search for new biocides with broad activity. Plant derived essential oils (EOs) have been known to show antimicrobial activity against specific pathogens and therefore could be considered as alternative antimicrobial agents in controlling pathogens. The present study was done to investigate the antimicrobial...

Asma Afroz Rowsni, Kamrul Islam, Md. Murad Khan and Md. Shahidul Kabir*

Department of Microbiology, Stamford University, Bangladesh.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4876-79

4876-4879

2324

846

33.

SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL SCREENING OF SOME TRANSITION METAL COMPLEXES WITH SUBSTITUTED ACETOPHENONE THIOSEMICARBAZONE

Complexs of Fe, Cu and Zn have been prepared by reacting metal chloride\sulphate with p-hydroxyacetophenone thiosemicarbazone, p-fluoroacetophenone thiosemicarbazone, p-bromoacetophenone thiosemicarbazone as ligands and their complexes were screened for their IR, NMR, and antifungal and antibacterial studies. . Acetophenone thiosemicarbazone ligands were prepared by the reaction of substituted ace...

Shyam Kumar Meena* and Meenakshai Jain

Lecturer in Chemistry Govt. P. G. College Dholpur Rajasthan, 328001, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4880-86

4880-4886

1637

785

34.

STUDY OF ENDOPHYTIC FUNGAL COMMUNITY OF MORINGA OLEIFERA FROM OMALUR REGION – SALEM

Endophytic fungi are ubiquitous in nature residing inside all the plant species contributing to their host plants by producing a plenty of substances that provide protection and survival value to the plant. Many researchers have proven that endophytes are a new and potential source of novel natural products for exploitation in modern medicine. This present study is undertaken to isolate and identi...

S. Rajeswari , S. Umamaheswari , D. A. Prasanth * and K.C.P. Rajamanikandan

Medical Microbiology Laboratory Department of Microbiology Periyar University, Salem-636011

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4887-92

4887-4892

1698

561

35.

AFFECT OF GRANULE SIZES, TYPES AND CONCENTRATIONS OF LUBRICANTS AND COMPRESSION FORCES ON TABLET PROPERTIES

By using five different sieve sizes of ascorbic acid granules, affects of granule sizes on tablet properties, i.e. tablet weight and hardness have been studied with standard methods. Affects of lubricant types and concentrations on tablet properties, i.e. tablet hardness and disintegration time have also been studied by using magnesium stearate and sodium stearyl fumarate as the lubricants for pro...

Md Abul Haider Shipar *, A. Wadhwa and C. Varughese

Toronto Institute of Pharmaceutical Technology, Toronto, Ontario, M1P 4X4, Canada.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4893-01

4893-4901

2630

618

36.

EVALUATION OF ANTIBACTERIAL ACTIVITY OF APIS HONEYS FROM PADERU FOREST DIVISION IN ANDHRA PRADESH INDIA

Antibacterial activity of the two honey samples produced by the honey bee (Apis florea), was standardized by Disc diffusion method. The two honey samples were tested at three concentrations (5, 10 and 15µl v/v) and zone of inhibition were measured against Staphylococcus aureus, Escherichia coli, Basillus subitis, Pseudomonas putida and Klebsiela pneumonia; unifloral and multifloral honey samples ...

R. Devender , H. Ramakrishna *, K. Karunakar Rao and Ch. Nirosha

Professor, Department of Botany, University College of Science, Saifabad Osmania University, Hyderabad-500004, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4902-07

4902-4907

1394

475

37.

EVALUATION OF GRASS SPECIES FOR ELEMENTS THROUGH ICP-OES TECHNIQUE

The aim of the study is to screen the grasses of South India for mineral nutrition. The results revealed that the grass species accumulate the major and minor elements at different concentrations. The maximum concentration (ppm) of macroelements in the analysed samples were 12270, 31310, 5309 and 3946 for Ca, K, Mg and P respectively. The maximum concentrations (ppm) of microelements were 50.05, 8...

R. Hari Babu and N. Savithramma

Department of Botany, S. V. University, Tirupati – 517 502, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4908-15

4908-4915

1614

856

38.

A pH-GRADIENT SAX-HPLC METHOD FOR DETERMINATION OF TRACE LEVELS OF OVER SULFATED CHONDROITIN SULFATE AND DERMATAN SULFATE IN HEPARIN SODIUM

A rapid and sensitive pH-gradient SAX HPLC method for the determination of Dermatan sulphate (DS) and trace levels of Oversulphated chondroitin sulphate (OSCS) in Heparin sodium was developed and validated. A pH gradient was opted to strike a balance between resolution and sensitivity because the response of OSCS was found to be better at neutral pH and the resolution between DS and Heparin was go...

G. Kavitha *, G. Nadamuni , C.S.Venkatesan, K. Mukkanti and V.N.S.M.V.G. Raju

Centre for Chemical Sciences and Technology, IST, JNTU, Kukatpally, Hyderabad – 500085, Andhra Pradesh., India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4916-24

4916-4924

2808

926

39.

SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF GLIBENCLAMIDE IN PURE FORM AND IN DOSAGE FORM

Two simple, sensitive and rapid spectrophotometric methods was developed for estimation of glibenclamide in pure and in pharmaceutical dosage forms. Method-A is a uv spectroscopic method with the absorption maxima at 276nm.Method-B is based on the oxidation/reduction of glibenclamide with iron (III) and chelation of iron with 3-methyl 2-benzothiozoline hydrazone(MBTH) to form green colored complex...

N. Umadevi *, CH. Mounika and Dr. I. Sudheer Babu

SIR C. R. Reddy College of Pharmaceutical Sciences, Eluru -534007, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4925-28

4925-4928

2175

756

40.

ANTIOXIDANT STUDIES, ERYTHROCYTE MEMBRANE STABILIZATION AND THROMBOLYTIC POTENTIAL OF DIALLYL DISULPHIDE

Diallyl Disulphide is an essential component of garlic which has numerous medicinal applications. Thus it was evaluated for its free radical scavenging potential. The compound was assayed for its ability to stabilize the erythrocyte membrane by osmotic fragility test and heat induced hemolysis assay. The thrombolytic potential was evaluated by the ability of the compound to dissolve the clot forme...

N. Suchetha Kumari *, T. Yogish Somayaji , R. Tejashvi , K. M. Damodara Gowda and C. Rao

Department of Biochemistry, K. S. Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11). 4929-32

4929-4932

1689

602

41.

STUDY OF ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL EVALUATION OF JATROPHA GOSSYPIFOLIA, SAPIUM SEBIFERUM, KIRGANELIA RETICULATA, PHYLLANTHUS FRATERNUS AND PEDILANTHUS TITHYMALOIDES

Present investigation deals with the evaluation of the antimicrobial activity of extracts of Jatropha gossypifolia Linn., Sapium sebiferum (L.) Roxb., Kirganelia reticulata (Poir) Baill., Phyllanthus fraternus Webster and Pedilanthus tithymaloides (Linn.) Poit. against Escherichia coli, Proteus vulgaris, Staphylococcus aureus and Bacillus cereus and Trichophyton mentagrophytes and T. rubrum. The a...

U. C. Bapat* and D. R. Mhapsekar

Department of Botany, St. Xavier’s College, Mahapalika Marg, Mumbai 400 001, Maharashtra State, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4933-41

4933-4941

2070

1127

42.

ANTIBACTERIAL ACTIVITY OF MEDICINAL PLANT AGAINST WOUND INFECTED PATHOGENS

Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. The effects of plant extracts on bacteria have been studied by a very large number of researchers in different part of the world. In this study antimicrobial activity of Acalypha indica were investicated against two strains of Human pathogenic bacteria. A total of 15 pus samp...

N. Divya*, S. Thenmozhi, B.T.Sureshkumar and M. Selvan,

Department of Microbiology, Vivekanandha College of Arts and Sciences for Women (Autonomous), Elayampalayam- 637205, Tiruchengode, Namakkal District, Tamilnadu (India).

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4942-47

4942-4947

3018

714

43.

DRUG PRESCRIBING PATTERNS DURING ANTENATAL CARE IN A TERTIARY CARE RURAL TEACHING HOSPITAL: A CROSS-SECTIONAL STUDY

Context: Drug treatment during pregnancy presents a special concern. All drugs should not be avoided. A better knowledge of parameters that determine teratogenicity may allow the physicians gain confidence. Aims: This study was conducted to understand the drug utilization practices during pregnancy in women from rural areas and poor socioeconomic background; classify them according to US-FDA categ...

C. J. Ghia *. S. Gajbhiye , L. Khobragade , J. K. Ved and G. S. Rambhad

Medical Advisor, Pfizer India Limited. 501, Krishna Kuni, 6th Road, Santacruz East, Mumbai 400055, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4948-52

4948-4952

1741

614

44.

SYNTHESIS OF NOVEL SERIES OF 2-AMINO-1, 2-DIHYDROISOQUINOLINE-3(4H)-ONE DERIVATIVES USED AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS

A facile synthesis of novel 2-amino-1,2-dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yield. The structure of all novel synthesized compounds was established based on Mass, 1H NMR, 13C NMR, ...

Umamaheswari Mani *, Suresh Rathinasamy , Vadivel Kaliyamoorthy , Sridharan Rajagopal and Palathurai Subramaniam Mohan

Department of Medicinal Chemistry, Orchid Chemicals and Pharmaceuticals Limited, Plot No. 476/14, Old mahabalipuram road, Sholinganallur, Chennai 600 119, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4953-62

4953-4962

1537

433

45.

FORMULATION CHARACTERIZATION AND IN-VITRO DIFFUSION STUDIES OF HERBAL EXTRACT LOADED MUCOADHESIVE BUCCAL PATCHES

The present paper deals with a novel approach in formulating and characterizing mucoadhesive buccal patches with the incorporation of herbal extract. In the present arena of Novel Drug Delivery System, delivery of drugs through buccal mucosa serves an easier method for utilization of drugs leading to reduction of dose frequencies and thereby tends to sustain the drug release. Buccal patches were p...

Sayan Bhattacharjee, S. Nagalakshmi and S. Shanmuganathan*

Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai-116 India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4963-68

4963-4968

1881

1093

46.

BIOLOGICAL STUDIES OF THE BARK OF ALBIZIA LEBBECK (L.) BENTH

  The phytochemical screening of the bark of Albizia lebbeck (L) showed positive test for tannin, alkaloid, flavonoid, terpenoid, phlabotannin, saponin, steroid and cardiac glycoside. In this article an attempt was made for biological studies (the antimicrobial activity, cytotoxicityand free radical-scavenging activity) of different extracts (hexane, methanol, ethyl acetate, water and buta...

Jerin Tasnim *, Anamika Saha , Shamim Ahmed , Nasim Sultana , Tanvir Muslim and Md. Azizur Rahman

Department of Chemistry University of Dhaka Dhaka-1000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4969-74

4969-4974

2473

691

47.

IN-VITRO CYTOTOXIC ACTIVITIES OF LEAF EXTRACT OF GARDENIA LATIFOLIA AIT. AND GARDENIA GUMMIFERA LINN.

Plants are the natural reservoir of many anticancer agents. Gardenia latifolia Ait. and Gardenia gummifera Linn. belonging to the family Rubiaceae. Gardenia Ellis. is a genus of 142 species, which occur in tropical and sub-tropical regions of Africa, South Asia, Australasia and oceania. The genus was named by Carl Linnaeus after Dr. Alexander Garden (1730-1791), a Scottish-born American naturalist...

K. Vindhya and S. Leelavathi

DOS in Botany, University of Mysore - 570 006, Karnataka, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4975-78

4975-4978

2024

784

48.

ATTENUATION OF HYPERGLYCEMIA AND OXIDATIVE STRESS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS BY AQUEOUS EXTRACT OF AVERRHOA BILIMBI LINN FRUITS

In the present study, the antidiabetic and antioxidant effect of aqueous extract of Averrhoa bilimbi Linn (ABAE) fruits were evaluated. Diabetes mellitus was induced in male Sprague Dawley rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). Oral administration of aqueous extract of Averrhoa bilimbi Linn (ABAE) (50mg/kg body weight) and metformin (100 mg/kg body wei...

Surya B. Kurup* and S Mini

Department of Biochemistry, University of Kerala, Kariavattom, Trivandrum, Kerala, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4979-86

4979-4986

1458

671

49.

TWO NEW METABOLITES; 7β-OH-UZARIGENIN AND 7β-OH-ODOROSIDE-H; THROUGH BIOTRANSFORMATION OF UZARIGENIN AND ODOROSIDE-H

Two new cardenolide metabolites, 7β-OH-uzarigenin (1M) and 7β-OH-odoroside-H (2M) were obtained through the biotransformation of uzarigenin (1) and odoroside-H (2). Compounds 1 and 2 were isolated from the air-dried roots of Nerium oleander L. The plant, belonging to family Apocynaceae, was collected in October, 2010 from Mansoura university garden in Egypt. The methylene chloride extract of the...

Ahmed A. Zaki *, Nadia E. Hashish , Mohamed A. Amer and M.-F. Lahloub

Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4987-92

4987-4992

2587

453

50.

ESTIMATION OF (-)-HYDROXYCITRIC ACID (HCA) IN GARCINIA LANCEAEFOLIA ROXB. USING NOVEL HPLC METHODOLOGY

ABSTRACT: (-)-Hydroxycitric acid (HCA) has been found to be the principal acid in genus Garcinia, which is a potential metabolic regulator of anti-obesity activity and inhibitor of lipogenesis. Presence of (-)-HCA as the principal acid has added importance to thegenus Garcinia. The present study deals with extraction and estimation of (-)-HCA from Garcinia lanceaefolia,collected from four administ...

Ankur Gogoi *, Nabajyoti Gogoi and Bijoy Neog

Ph.D. Scholar, Centre for Studies in Biotechnology, Dibrugarh University, Dibrugarh- 786004, Assam, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4993-97

4993-4997

2127

2581

51.

IN-VITRO ANTI-INFLAMMATORY STUDIES IN CLEOME VISCOSA L. AND CLEOME BURMANNI W. & A. (CLEOMACEAE)

The present study evaluates the anti-inflammatory potential of the methanol and chloroform extracts of Cleome viscosa and C. burmanni by in-vitro methods.The anti-inflammatory property of the extracts was assessed using albumin denaturation assay, proteinase inhibitory activityand hyaluronidase inhibition assay and the results compared against reference drugs such as Aspirin and Indomethacin. The ...

Lakshmi S. Pillai* and Bindu R. Nair

Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram – 695 581. Kerala, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4998-03

4998-5003

1977

876

52.

SYNTHESIS AND BIOCIDAL ACTIVITY OF Co (II) AND Zn (II) COMPLEXES OF SULFA DRUG SCHIFF BASES

The novel Co (II) and Zn (II) complexes have been synthesized by reaction of CoCl2/ZnCl2 with Schiff bases of benzoyl derivative of 3-methyl-1-phenyl-2-pyrazoline-5-one and sulfa drugs in 1:2 ratio. The synthesized complexes were screened/tested for their antimicrobial activity against pathogenic bacterial strains i.e. E. coli, Staphylococcus aureus strain I, Staphylococcus aureus strain II, Staph...

S. Roy* and A. D’souza

Department of Chemistry and Biochemistry, St. Aloysius’ (Autonomous) College, 1 Ahilya Bai Marg, Pentinaka Chowk, Sadar, Jabalpur, Madhya Pradesh- 482001, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5004-10

5004-5010

1768

570

53.

ANTI-BIOFILM ACTIVITY OF EUCALYPTUS GLOBULUS OIL ENCAPSULATED SILICA NANOPARTICLES AGAINST E. COLI BIOFILM

The inhibitory effect of Eucalyptus globulus oil was evaluated against the E. coli and the minimum inhibitory concentration (MIC) value of Eucalyptus globulus oil was calculated by agar dilution assay, which was found to be 1µl/ml. The E. coli biofilm was formed on catheter surface and quantified by crystal violet staining system. The crystal violet quantification method showed maximum biofilm af...

Suhaga Dohare *, Shyam Dhar Dubey , Manmohit Kalia , Preetam Verma , Himanshu Pandey, Nand Kumar Singh and Vishnu Agarwal

Department of Biotechnology, Motilal Nehru National Institute of Technology (MNNIT), Teliarganj, Allahabad, Uttar Pradesh - 211004, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5011-16

5011-5016

2246

646

54.

FORMULATION AND EVALUATION OF NIFEDIPINE LOADED CHITOSAN MICROSPHERS FOR MUCOADHESIVE DRUG DELIVERY

Nifedipine loaded mcoadhesive micropshres were prepared by o/w/o emulsification cross linking method using natural polymer chitosan. Microsphres with particle size range b/n 50-300 µm were obtained by this method. The prepared microspheres were evaluated for its drug loading, surface properties, in-vitro release profile. The diffusion and permeation characteristic of the drug is studied by using ...

Preethi Sudheer * and Ramakrishna Shabaraya A.

Associate Professor, Dept. of Pharmaceutics, Krupanidhi College of Pharmacy Bangalore -35, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5017-22

5017-5022

1708

530

55.

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3β INHIBITORS AS ANTIDIABETIC AGENTS

To synthesize structurally modified novel Glycogen Synthase Kinase-3βinhibitors to overcome insulin resistance in type 2 diabetes mellitus and to overcome associated health problems with reducing morbidity, mortality and economic costs of diabetes. Methods. Nineteen Phenylmethylene hydantoin analogs were designed and docked in the ATP binding site of GSK-3β by Molegro Virtual Docker 2006.1.5...

Keerti Jain *, Sapna Malviya , Arun Kumar Gupta and Anil Kharia

Assistant Professor, Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Chemistry, Modern Institute of Pharmaceutical Sciences, Indore, (M.P.), India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5023-39

5023-5039

2671

689

56.

EXPLORING THE POSSIBLE MECHANISM OF ALBIZIA LEBBECK COMPONENTS BINDING WITH DRUG TARGETS OF BRONCHIAL ASTHMA –AN INSILICO AND CLINICAL ANALYSIS

Asthma is a multi factorial disease characterized by airflow obstruction, wheezing and dysonea and for this many genes are responsible. In this study, an attempt has been made to identify genes along with the proteins encoded by them which are responsible for Asthma along with clinical trials. In the practice of Ayurveda, it’s well established that shirish (Albizia lebbeck) can be used as a trea...

Mukamchem Yim, B.P. Sarma , Subrata Sinha *, Hemchandra Deka , Hirakjyoti Deka , Pratap Parida , Arabinda Ghosh and Surabhi Johari

Center for Bioinformatics Studies, Dibrugarh University, Dibrugarh-786004, Assam, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5040-49

5040-5049

1792

640

57.

SYNTHESIS OF SOME 2, 3-DIARYL-6-ISOXAZYL-QUINOLINE-4-CARBOXYLIC ACID DERIVETIVES

A series of some new substituted quinolines were synthesized by Doebner reaction, a three component coupling of various aromatic amines with two aldehydes and phenyl pyruvic acid, the intermediate 2, 3-diary-6-acetyl-quinoline-4-carboxylic acids were reacted with various aromatic aldehydes in the presence of basic medium using Claisen-Schmidt condensation in order to afford the corresponding chalc...

Hiba H. Mahgoub , Amna Bentwahab E. M. Hussein and A. E. M. Saeed *

Department of Chemistry, College of Science, Sudan University of Science and Technology, Khartoum, Sudan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5050-56

5050-5056

1569

655

58.

EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM AND SYNTHESIS OF ITS DERIVATIVES: COMPARATIVE EVALUATION OF ANTI-OXIDANT ACTIVITIES

The objective of this study was to extract ursolic acid (UA) from Ocimum sanctum,to synthesize its derivatives and to examine the improvement of antioxidative activity. Present work involved structural modification of UA at the C-3 and C-28 positions. UA derivatives namely UA-4 and UA-7 with distinct property were synthesized. Comparative evaluation of anti-oxidant activity of UA, UA-4 and UA-7 us...

Apsara Batra* and V. Girija Sastry

Assistant Professor Pharmaceutical Chemistry Division, NCRD’S Sterling Institute of Pharmacy, Nerul-400706, Navi-Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5057-63

5057-5063

1522

447

59.

HALOGENATED TRIAZINEDIONES BEHAVE AS ANTAGONISTS OF PKR1: IN-VITRO AND IN-VIVO PHARMACOLOGICAL CHARACTERIZATION

Different prokineticin receptor antagonists, based on the triazinedione scaffold, were synthesized by a new efficient method. Here we demonstrated that 5-benzyl triazinediones substituted in position para of the benzyl group with halogens provide compounds endowed with interesting selectivity for the Prokineticin receptor 1 (PKR1). BRET technology indicates that such substitution results in increa...

R Lattanzi , C Congiu , V Onnis , A Deplano , S Salvadori , V Marconi , D Maftei , A Francioso , C Ambrosio , I Casella , T Costa , G Caltabiano , M T Matsoukas , G Balboni L Negri

Professor of Pharmacology Dept. of Physiology and Pharmacology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).5064-72

5064-5072

1340

429