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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 6 (2015) - Issue 5, May

Review Articles

 
Title
Views
PDF
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1.

UPBRINGING OF CHILDREN AND ROLE OF UNANI MEDICINE IN CHILD HEALTH CARE: A REVIEW

Infancy is the most important period of human life, because a infant grows up to be a healthy teen and adult, parents should have to take precautions seriously so as to impart a healthy life  to their child, since the immunity of children is not so strong as that of adults so they are prone to diseases and illnesses, the medicine used in conventional system of medicine for such pediatrics ailment...

Azizur Rahman and S. Javed Ali *

Department of Medicine, National Institute of Unani Medicine, Bangalore - 91 India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(5).1820-25

1820-1825

3508

1159

2.

TRANSDERMAL PATCHES: PHYSIOCHEMICAL AND IN-VITRO EVALUATION METHODS

Various drugs are available these days, which may either require long term administration via multiple doses or may be susceptible to enzymes and first pass-metabolism or all the above.  One way to administer such drugs is through the transdermal route. After a transdermal delivery system is designed, it is important to evaluate it for various essential parameters that help us determine how effec...

Rishabh Bahl and Piyush Bafna

Bits-Pilani, Hyderabad Campus, Department of Pharmacy, India

DOI: 10.13040/IJPSR.0975-8232.6(5). 1826-36

1826-36

4823

1183

Research Articles

 
Title
Views
PDF
Cited
3.

A FORMULA OPTIMIZATION OF NIFEDIPINE TABLET COMBINATION WITH FLOATING MUCOADHESIEVE SYSTEM IN A SIMPLEX LATTICE DESIGN

Nifedipine has poor dissolution characteristics due to its poor wetability and dispersibility in body fluits,  floating mucoadhesieve system in a Simplex Lattice Design were combined in an attempt to prolong its gastric residence time. This research was aimed to find an optimum formula, through finding effects of adding polymers (Carbopol 934P, gelatin) concentration and optimum gas generating, t...

Endang Diyah Ikasari *, Achmad Fudholi , Sudibyo Martono and Marchaban

Yayasan Pharmasi College of Pharmacy, Semarang - 50193, Indonesia

DOI: 10.13040/IJPSR.0975-8232.6(5).1837-44

1837-44

2588

969

4.

FORMULATION OF CLINDAMYCIN NANO-EMULSION

Nano-emulsions consist of fine oil-in-water or water-in-oil dispersions, having droplets covering the size range of 10 - 600 nm. The aim of this study is to formulate nano-emulsion of Clindamycin by using Emulsion Phase Inversion method and olive oil as the oil phase. Pseudo ternary phase diagram was first developed by using distilled water, olive oil and mixture of surfactants (Tween®80 and Span...

K. Jiyauddin *, A. Fadli , J. C. Wei , A. Jawad , A. D. Samer , M. Kaleemullah, S. Budiasih, S. Rasha , M. R. Rasny , Y. K. Sung , A. H. Junainah , H. Todo and Y. Eddy

School of Pharmacy, Management & Science University, 40100 Shah Alam, Selangor Darul Ehsan, Malaysia

DOI: 10.13040/IJPSR.0975-8232.6(5).1845-54

1845-54

4502

1425

5.

THE DEVELOPMENT OF CHITOSAN NANOPARTICLES FROM HIBISCUS SABDARIFFA L CALYX EXTRACT FROM INDONESIA AND THAILAND

Rosella (Hibiscus sabdariffa L) calyx has been reported to have an antioxidant activity. Antocyanidin is the major compound of rosella and has low bioavailability as an ionic form. Rosella extract is an ucceptable due to high acidity. Development of chitosan nanoparticle from Hibiscus sabdariffa extract were expected to improve the bioavailability and the acidity problem. We studied the optimum pH...

Nurkhasanah*, Tedjo Yuwono, Laela Hayu Nurani, Muhammad Ikhwan Rizki and Krisana Kraisintu

Faculty of Pharmacy, Ahmad Dahlan University, Jl. Prof Soepomo, Janturan, Yogyakarta, Indonesia

DOI: 10.13040/IJPSR.0975-8232.6(5).1855-61

1855-61

3020

1314

6.

CARDIOPROTECTIVE EFFECT OF IVABRADINE VERSUS CARVEDILOL IN RATS

The discovery of the f-channel and its role in regulating pacemaker activity lead to the development of new pharmacological agents such as ivabradine, which target these f-channels causing a reduction in heart rate by inhibiting the /fcurrent. The aim of the present work was designed to evaluate the cardioprotective effect of ivabradine on experimentally- induced myocardial infarction and adrenali...

El sayed A. Osman MD, Nasr N. Zaki MD, Samia M. M. Elshiaty MD, Hanan T. Emam MD and Fatma F. Hendawi

Department of pharmacology, Benha faculty of Medicine, Benha University, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(5).1862-76

1862-76

2927

1128

7.

FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF SALBUTAMOL SULPHATE USING XANTHAN GUM AND HYDROXYPROPYL METHYLCELLULOSE POLYMER BLEND

Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its...

Z. Yilma, A. Belete and T. Gebre-Mariam *

Professor of Pharmaceutics Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.

DOI: 10.13040/IJPSR.0975-8232.6(5).1877-92

1877-92

2694

972

8.

SMARTPHONE APPLICATIONS FOR IMPROVED PHARMACEUTICAL CARE

Advancement in mobile technologies are seen with introduction of many smartphone applications. These advancements in the field of smartphone applications can be exploited to improve pharmaceutical care practice ultimately leading to betterment of patients. Objectives of the study were to identify, evaluate and review current smartphone applications available at various platforms and recommended fo...

Maryam Hamdan Al Badi and Havagiray R. Chitme*

Department of Pharmacy, Oman Medical College, Bausher Campus, Muscat, Sultanate of Oman

DOI: 10.13040/IJPSR.0975-8232.6(5).1893-99

1893-99

2796

686

9.

ESTIMATION OF MOISTURE AND CRUDE PROTEIN CONTENT OF LOCALLY AVAILABLE RAW MATERIALS FOR POULTRY FEED

There are some locally available domestic material in our country that can be used in poultry feed. The uses of local material will decrease the feed cost as well as ensure the availability of raw materials. In this investigation we have selected twelve locally available domestic materials that are low cost and nutritious for poultry health. These raw materials play an important role on poultry he...

Md. Saiful Islam *, Md. Moinul Haque and Md. Shakhawat Hossain

Department of Applied Chemistry & Chemical Engineering, Rajshahi University, Rajshahi, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.6(5).1900-06

1900-06

4817

804

10.

ANALYTICAL AND BIOANALYTICAL UHPLC-MS METHOD VALIDATION FOR DETERMINATION OF METFORMIN, A BIGUANIDE AND SITAGLIPTIN, A DPP-4 INHIBITOR

A very sensitive, rapid and simple Ultra High Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS) method has been developed and validated for the simultaneous estimation of Metformin Hydrochloride and Sitagliptin Phosphate in standard and tablet formulation. The chromatographic separation of the drugs was achieved on a Hypersil Gold C18 analytical column (150x3mm, 5µ) with an isocratic...

Mital Nakrani, Deepika Bairagee , Pradeep Goyal and B. Santhakumari *

Principal Scientist, CSIR-National Chemical laboratory, Dr. Homi Bhabha Road, Pune (Maharashtra), India.

DOI: 10.13040/IJPSR.0975-8232.6(5).1907-14

1907-14

2661

1396

11.

ESTIMATION OF TERIFLUNOMIDE ALONG WITH CONCOMITANT DRUGS IN DIFFERENT BIOLOGICAL MATRICES USING LC-MS/MS

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC–MS/ MS) assay method has been developed and fully validated for the quantification of Teriflunomide (TFM), in different biological matrices like human plasma, rat plasma, rabbit plasma and dog plasma and as well as their serums. The analytes were extracted from 200 µL aliquots of each plasma/serum via protein prec...

A. Suneetha * and Raja Rajeswari K.

Professor & HOD, Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi road, Guntur-522 002, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(5).1915-23

1915-23

2435

1383

12.

EFFECT OF METOPROLOL AND ATORVASTATIN ON OXIDATIVE STRESS IN SOUTH INDIAN CARDIOVASCULAR PATIENTS

Over production of oxygen free radicals, which is mainly mediated by super oxide, occurs in human atherosclerosis. Metoprolol and atorvastatin are the drugs which found to be more prescribed drugs for cardiovascular patients. In the present study, an attempt has been made to evaluate the levels of serum Glutathione, Total anti-oxidant status, lipid peroxidation (malondialdehide) and liver funct...

Mahender Vattipalli and Narsimha Reddy Yellu*

Department of Pharmacology and Clinical Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal – 506 009, Telangana State, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).1924-29

1924-29

2232

665

13.

SYNTHESIS AND SPECTRAL STUDIES OF Ni(II) COMPLEXES WITH 2-HEPTANONESEMICARBAZONE AND 2-HETANONETHIOSEMICABAZONE

Complexes of Nickel(II) with 2-heptanonesemicarbazone (hsc) and 2-heptanonethiosemicabazone (htc) have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic moments, mass, IR and electronic/spectral studies. Synthesized complexes were found to have a general composition of Ni(L)2X2 (where X=Cl-, 1/2SO42-, NO3-, ClO4-, NCS-, CH3COO- and L=hsc or htc). Mo...

Pravita Kumar, Roopakumari and Sulekh Chandra*

Department of Chemistry, Zakir Husain Delhi College, JLN Marg, New Delhi-110002, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).1930-35

1930-35

1849

708

14.

PENETRATION OF DICLOFENAC FROM NOVEL QUICK PENETRATING SOLUTION. A COMPARATIVE SCINTIGRAPHY STUDY WITH GEL

Topical NSAIDs do not effectively cross the skin due to barrier of stratum corneum. The aim of the study was to evaluate penetration of diclofenac from a novel quick penetrating solution (QPS) and conventional gel prepared using Tc-99 m labeled diclofenac. The study was conducted in 16 healthy subjects, divided in 4 groups, each with 4 subjects. In first three groups, the applications were made on...

Sanjay Kumar H. Maroo*, Ketan R. Patel and Aseem Bhatnagar

Sr. General Manager Medical Services Department, Troikaa Pharmaceuticals Ltd., Commerce House, Opp. Rajvansh Apartment, Satya Marg, Bodakdev, Ahmedabad - 380054 Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).1936-42

1936-42

4427

1288

15.

MOLECULAR DOCKING ANALYSIS OF 3- SUBSTITUTED 5-HYDROXY COUMARIN DERIVATIVES AS VITAMIN K EPOXIDE REDUCTASE INHIBITOR

Warfarin and coumarin containing drugs act on Vitamin K epoxide reductase to show its anti-coagulant activity. In this study, three different series of 5- hydroxy coumarin containing phenyl, furan and pyran substituents at third position were designed. Molecular docking studies were performed to determine binding modes and affinities of ligand molecule towards Vitamin K epoxide reductase. In docki...

Ashwini M. Londhe* and Anuruddha R Chabukswar

Pharmaceutical Chemistry Department, Maeer’s Maharashtra Institute of Pharmacy, Ex-Serviceman Colony, Kothrud, Pune-411038, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(5).1943-49

1943-49

1901

739

16.

SCREENING, ISOLATION AND IDENTIFICATION OF NITRILASE PRODUCING BACTERIA FROM SOIL

Enzymes are identified as key catalysts in various processes occurring within the living cells. The role of various enzymes is constantly investigated to find their novel applications. Nitrilase is one such enzyme which carries out the hydrolysis of carbon-nitrogen bonds except for amides. This catalytic property of nitrilase is exploited to generate corresponding chiral carboxylic acids. These ch...

Vikas Verma * and Preeti Sangave

Department of Pharmaceutical Chemistry and Pharmaceutical Biotechnology, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management (SPPSPTM), SVKM’s NMIMS (Deemed to be University), V.L. Mehta Road, Vile Parle (W), Mumbai (Maharashtra) – 400056, India

DOI: 10.13040/IJPSR.0975-8232.6(5).1950-57

1950-57

3146

806

17.

TOXICOLOGICAL EFFECT OF MALLASINDURA (MSL) ON LIVER FUNCTION PARAMETERS OF RAT PLASMA AFTER CHRONIC ADMINISTRATION

Mallasindura (MSL), a widely used ayurvedic preparation is used for the treatment of bronchial asthma. It contains rasa –mercury, Rasakarpura -mercurial compound, Bali –purified and processed sulphur and Malla-purified arsenic oxide with herbal juices.  The liver function parameters of rat plasma were studied after chronic administration of MSL. The animals used to conduct this experiment wer...

Gulshanara Begum * Kaiser Hamid and MSK Choudhuri

Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh,

DOI: 10.13040/IJPSR.0975-8232.6(5).1958-64

1958-64

1985

583

18.

A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF MOXIFLOXACIN AND PREDNISOLONE IN BULK AND THEIR COMBINED DOSAGE FORM

A simple, specific, and precise stability indicating reverse phase high performance liquid chromatography method was developed and validated as per the ICH guidelines for the simultaneous determination of Moxifloxacin and Prednisolone in bulk and combined dosage forms. The quantification was carried out by using Zodiac C18 (250mm*4.6mm, 5μ) column at 250c with Acetate Buffer pH 4.5: Methanol: Ace...

Naga Raju Potnuri*, Devala Rao G and Rajendra Prasad Y

Associate Professor Joginpally B.R. Pharmacy College, Yenkapally (V), Moinabad (M), R.R. (Dist.), A.P, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).1965-73

1965-73

1907

658

19.

GASTROPROTECTIVE ACTIVITY OF FICUS DALHOUSIAE MIQ. ROOTS ETHANOLIC EXTRACT ON INDOMETHACIN AND COLD RESTRAINT STRESS INDUCED ULCERS IN WISTAR ALBINO RATS

Ficus dalhousiae Miq. is a plant found in Andhra Pradesh and Tamil Nadu on rocky hill top of dry deciduous forests. As it possesses antioxidant property wherein it reduces the elevated levels of ROS, the intent of the present study was to evaluate the Gastro protective effect of Ficus dalhousiae Miq Root ethanolic extract (FDREE) by means of Indomethacin and Cold Restrain stress induced Ulcers in ...

Mohammed Atif *, Mohammed Abdul Muqtadar , Shaik Abdul Rahman , Mohammed Abdul Naser Faisal

11-2-973, Dawood Villa, Bazar Ghat, Nampally Hyderabad 500004

DOI: 10.13040/IJPSR.0975-8232.6(5).1974-81

1974-81

1902

720

20.

OPTIMIZATION OF MEDIUM COMPONENTS AND FEEDING STRATEGIES FOR EPSILON POLY-L-LYSINE PRODUCTION BY STREPTOMYCES NOURSEI NRRL 5126

Epsilon poly-L-lysine (ε-PL) is a nontoxic biopolymer widely used in food and pharmaceutical industry. The present work reports the nutritional requirements for submerged fermentation of Streptomyces noursei NRRL 5126 using a combination of one factor at a time and statistical orthogonal array method. Two-fold increase in ε-PL productivity (74 mg/L) was observed using optimized medium containing...

A. H. Chheda and M. R. Vernekar*

Department of Biotechnology and Bioinformatics, D. Y. Patil University, C.B.D Belapur, Navi Mumbai 400614, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).1982-91

1982-91

2488

909

21.

BOTANICAL AND GENETIC CHARACTERIZATION OF FICUS CYATHISTIPULA WARB. GROWING IN EGYPT

Ficus cyathistipula Warb. growing in Egypt is an evergreen tree, reaching up to six meters high. The macro- and micromorphological characters of the stem, leaf and fruit of the plant have been studied with the aim to find the diagnostic features and pointed towards their identification in both entire and powdered forms: partly united, leafy and conspicuous stipules, numerous ca-oxalate crystals, c...

Fatma S. El-Sakhawy , Hanaa A. Kassem , Sabah H. El-Gayed , Dina R. Abou-Hussei, * and Mayy M. Mostafa

Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, P.O. Box 80260, Saudi arabia

DOI: 10.13040/IJPSR.0975-8232.6(5).1992-04

1992-04

2270

644

22.

FORMULATION AND IN VITRO EVALUATION OF DRY COATED FLOATING PULSATILE DRUG DELIVERY SYSYTEM OF ENALAPRIL MALEATE

This research work deals with the development and evaluation of a floating pulsatile drug delivery system used in the treatment of hypertension intended as chronopharmacotherapy.  Serious cardiovascular complications have been seen in majority of individuals with early morning-surge in blood pressure. The floating- pulsatile concept can help to deliver the drug at definite place and time when sym...

Arpit Mishra*, Aadesh Kumar, Manoj Bhardwaj and Vaseem Fateh

Department of Pharmaceutical Science, Kumaun University, Bhimtal Campus, Block Road, Bhimtal-263136, Distt. Nainital, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2005-12

2005-12

2462

958

23.

UV VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF SERRATIOPEPTIDASE AND DICLOFENAC SODIUM IN THEIR BULK AND COMBINED DOSAGE FORM

A simple, rapid, specific, precise and accurate UV Spectrophotometric method for simultaneous estimation of Serratiopeptidase and Diclofenac sodium in bulk and tablet formulation has been developed. UV Spectrophotometric method was developed for the simultaneous estimation of Serratiopeptidase and Diclofenac sodium in tablet formulation. In present work, simple, sensitive, accurate and economical ...

Manasi Wagdarikar J.*, Dr. Anagha Joshi M. and Nilesh Ghorpade A.

Department of Pharmaceutical Chemistry, SCES’s Indira College of Pharmacy, Tathawade, Pune, MH, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2013-18

2013-2018

4813

1481

24.

MOLECULAR DOCKING AND 3D-QSAR ANALYSIS STUDIES OF MMP-12 INHIBITORS

Matrix metalloproteinase 12 (MMP-12) inhibitions is an important research topic because of its wide range of associated health implications. The interaction mode of a series of pyridinone compounds with MMP-12 has been studied using molecular docking and 3D-QSAR approaches. Flexible docking was used for the determination of active conformation and molecular alignment. Comparative molecular field a...

Shravan Kumar Gunda *, Lokesh Kumar Akula , Salwa Shaik,Seshagiri Bandi and Mahmood Shaik

Division of Bioinformatics , Osmania University, Hyderabad 500007, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2019-27

2019-27

2056

670

25.

FORMULATION AND CHARACTERIZATION OF PARENTERAL IN SITU IMPLANTS OF TARIQUIDAR BIMESYLATE

The objective of present study was to formulate and evaluate Tariquidar bimesylate subcutaneous in situ implants in order to minimize the frequency of doses and toxicity and to improve the therapeutic efficacy. The anthranilic acid derivative, tariquidar (XR9576), is a potent and selective P-gp inhibitor being developed clinically for the treatment of multidrug resistant tumors. Tariquidar bimesyl...

R. Bindu , Prathima Srinivas *, D S Ravindrababu

Principal, Sri Venkateshwara College of Pharmacy, Hitech City Road Madhapur, Hyderabad- 500081 Telengana, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2028-34

2028-34

3072

823

26.

APPLICATION AND COST-EFFECTIVENESS OF LAMP (LOOP-MEDIATED ISOTHERMAL AMPLIFICATION) TECHNOLOGY FOR AUTHENTICATION OF MEDICINAL PLANTS PODOPHYLLUM HEXANDRUM ROYLE

We have developed a novel LAMP-based molecular marker for easy and fast identification of Podophyllum hexandrum Royle (Indian May apple). It is an important medicinal plant valued all over the world. It have both anti-cancer (pro-oxidant ability) and radioprotective (antioxidant ability) effects respectively. The LAMP-based molecular was constructed based on genomic DNA of P. hexandrum that amplif...

Waleed M. Al-Shaqha , Mohsin Khan , Arezki Azzi and Anis Ahmad Chaudhary *

College of Medicine Al-Imam Muhammad Ibn Saud Islamic University (IMSIU), Riyadh-13317-7544, Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.6(5).2035-41

2035-41

1665

606

27.

EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM: MODULATORY EFFECT OF URSOLIC ACID ON HYDROGEN PEROXIDE INDUCED DNA DAMAGE IN HUMAN LYMPHOCYTES

The objective of the present study was to i) Extract ursolic acid , a pentacyclic triterpenoid from Ocimum sanctum; ii) develop a HPTLC based method for its quantification; and iii) investigate ursolic acid dependent adaptive response to cytotoxic effect of hydrogen peroxide. To elucidate the possible underlying mechanism(s), lymphocytes were co-incubated with hydrogen peroxide (0, 10, 25 and 100 ...

Apsara Batra* and V. Girija Sastry

Assistant Professor Pharmaceutical Chemistry Division, NCRD’S Sterling Institute of Pharmacy, Nerul-400706, Navi-Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2042-51

2042-51

2128

635

28.

SPECTROPHOTOMETRIC DETERMINATION OF ARIPIPRAZOLE AND TAPENTADOL USING CHLORANILIC ACID REAGENT

The objective of the present work is to develop simple, precise and accurate colorimetric methods for the estimation of aripiprazole (ARP), tapentadol (TAP) using chloranilic acid reagent. ARP belongs to the class of antipsychotics. TAP is centrally acting analgesic drug. The methods are based mainly on charge transfer complexation of these drugs with p-chloranilic acid to give magenta purple colo...

Y. Naga Sri Ramya, R. Vijayalakshmi* and M. D. Dhanaraju

Research lab, GIET School of Pharmacy, Rajahmundry Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2052-55

2052-55

2476

680

29.

BIOANALYTICAL METHOD DEVELOPMENT OF METFORMIN CO-ADMINISTERED WITH OCIMUM SANCTUM FOR POTENTIAL BIOENHANCER ACTIVITY

Objective: The present study was an effort to evaluate the effect of Ocimum sanctum on plasma concentration of metformin HCl and investigating its pharmacokinetic parameters using bioanalytical method. Methods: Seven groups comprising of six rats were used. Group I served as normal control and Group II was negative control of Streptozotocin induced Diabetic rats. Group III received 100mg/kg p.o. M...

Vikram Kokare, M.A. Nagras *and S.K. Patwardhan

Assistant Professor, Department of Pharmaceutical Chemistry, Sinhgad College of Pharmacy, S.N0. 44/1, off Sinhgad Road. Vadgaon (Bk.), Pune- 411 041, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2056-65

2056-65

2114

696

30.

ANTITUMOR POTENTIAL OF STANDARDIZED EXTRACT FROM AEGLE MARMELOS ROOT ON DALTON’S LYMPHOMA INDUCED MICE MODEL

The antitumor property of the successive, standardized methanolic (MeOH) extract of Aegle marmelos roots (MAM) was investigated in Dalton’s ascites lymphoma mice model. Materials and methods: Flavonoid present in MAM was quantitatively estimated using high performance thin layer chromatography. MAM (100, 300 mg/kg) was administered orally for 15 days to assess antitumor activity. The tumor was i...

G. Syamala *, M. Ramanthan. and S. P. Dhanabal

Associate Professor PSG College of Pharmacy, Peelamedu, Coimbatore -641004

DOI: 10.13040/IJPSR.0975-8232.6(5).2066-71

2066-71

1650

687

31.

FORMULATION AND EVALUATION OF GLICLAZIDE ETHOSOMES AS A NOVEL DRUG CARRIER

The main aim of the present investigation was to evaluate transdermal potential ethosomes bearing anti-diabetic drug Gliclazide. Total eight formulations (F1-F8) of ethosomes were prepared by using cold method with three different concentrations of phospholipid (0.5, 1, 2 % w/w) and ethanol (10, 20, 30 % v/v) and it was compared with hydroethanolic solution. They were evaluated for vesicular shape...

R. Lamsal , A. Geethalakshmi * and S. Gubbala

The Oxford College of Pharmacy, Begur road, Bangalore, Karnataka, India Bangalore-560068, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2072-80

2072-80

2538

946

32.

COMPERATIVE EFFICACY OF THREE INDIGENOUS MEDICINAL PLANTS (TURMERIC, GARLIC, AND ALOE) WITH LOCALLY AVAILABLE PATENT DRUG NEBANOL® AGAINST ARTIFICIALLY INDUCED WOUND IN GUINEA PIGS

The experiment was performed at the Department of Pharmacology in collaboration with the animal house Microbiology Department, Bangladesh Agricultural University, Mymensingh during the period from Jan 2005 to May 2005. To complete the research work following steps were followed.The aim of this study was to assess the possible comparative efficacy of Turmeric (Halud), Garlic (Rashun) and Aloe (Ghri...

Mohammad Abu Taher * Hasib Sheikh, Md Shahinoor Rahman Dulal , Md. Khairul Alam, Md. Mustofa Nabi and Abdul Awal

Lecturer Faculty of Unani and Ayurvedic Medicine, Hamdard University Bangladesh (HUB), New town Sonargaon, Narayanganj. Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.6(5).2081-89

2081-89

2415

774

33.

MODELING OF BAKER TRIAZINE DERIVATIVES AS DHFR INHIBITORS USING QUANTUM CHEMICAL DESCRIPTORS

DHFR being involved in many important cell processes, its inhibition has long been an attractive goal for the development of chemotherapeutic agents. In present work, efforts have been made to model the DHFR inhibitory activity of a series of 4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine derivatives to identify the structural requirements for the binding affinity between the receptor and Tri...

R. Chouksey*, S. Malik , A. Thakur and N. Upadhyay

Assistant Professor Chameli Devi Group of Institutions Near Toll Naka, Khandwa Road Indore (M.P.) 452020, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2090-96

2090-96

1710

617

34.

ANALYSIS OF MOLECULAR INTERACTION IN TRAMADOL DRUG WITH ALCOHOLS UNDER ULTRASONIC TECHNIQUE AT TEMPERATURE T= 278.15 K

The prime aim of this research paper is to find out the various kinds of intermolecular interactions in the alcoholic tramadol below the room temperature. Study of molecular interaction in the mixture of alcohols namely ethanol,1-propanol,1-butanol with tramadol drug at T = 278.15 K have been examined under the ultrasonic technique at 2MHz. Ultrasonic data of drug solutions has been evaluated at v...

Sanjay P. Ramteke * and Omprakash P. Chimankar

Department of Physics, S.P. College, Chandrapur.-442402 (M.S.) India

DOI: 10.13040/IJPSR.0975-8232.6(5).2097-02

2097-02

1682

631

35.

SYNTHESIS OF 4-(4-DI SUBSTITUTED AMINO(PHENYL) METHYL)1-3-HYDROXY NAPHTHALEN -2-OL)DIZENYL

The reaction between 2-naphthol, aryl aldehydes and ammonia or amines yields aminobenzyl naphthols in process known as Betti reaction; this procedure can be interpreted as extension of the Mannich condensation, with formaldehyde replaced by aromatic aldehydes, secondary amine by ammonia and the C – H acid by an electron-rich aromatic compound such as 2-naphthol. 1,3-Disubstituted-2,3-dihydro-1H-...

R. S. M. Bashier*, A. E. M. Saeed and E. E. Barakat

Department of Chemistry, Faculty of Education, University of Zalingei, P.O box 6, Zalingei, Central Darfur State, Sudan

DOI: 10.13040/IJPSR.0975-8232.6(5).2103-11

2103-11

1737

961

36.

EVALUATION OF IN VITRO IMMUNOMODULATORY EFFECTS OF SOYABEAN (GLYCINE MAX. L) EXTRACTS ON MOUSE IMMUNE SYSTEM

To explore the potentially health modulatory role of most proteinaceous leguminosae plant, Soyabean, the present study was intended to evaluate the in-vitro immunomodulatory activity of dry seeds of Glycine max. L. Effect of ethanolic and methanolic extracts of soyabean was evaluated at various concentrations (800μg/ml to 6.25μg/ml) for secretion of various mediators. Immunomodulatory activity o...

T. Anitha, K. Parameswari, B. Kishori and R. Usha *

Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam, Tirupati – 517502, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2112-20

2112-20

2002

670

37.

ELECTROCHEMICAL BEHAVIOR AND ANALYSIS OF KETAMINE IN PHARMACEUTICAL FORMULATIONS BY VOLTAMMETRIC TECHNIQUES

The electrochemical behavior of Ketamine is studied by employing D.C. Polorography (DCP), Cyclic Voltammetry (CV) and Differential Pulse Polarography (DPP) in universal buffers of pH ranging from 2.0-12.0. The kinetic parameters, such as transfer coefficients, diffusion coefficients and heterogeneous forward rate constant values were evaluated by employing these techniques. Differential Pulse Pola...

Ijpsr

V. Krishnaiah, R. Chenna Krishna Reddy, K. Madhusudhana Reddy, Y. V. Rami Reddy*

DOI: 10.13040/IJPSR.0975-8232.6(5).2121-26

2121-26

2018

862

38.

PHARMACOPHORE MAPPING AND VIRTUAL SCREENING ON HUMAN ALPHA AMYLASE INHIBITORS

Diabetes is a non communicable chronic metabolic disease characterized by high blood glucose level in the body. Targeting alpha amylase to control diabetes has long been studied. This study focused on developing pharmacophore model for set of inhibitor that possess anti amylase activity based on previous studies. Developing a pharmacophore model for these compound yields a hypothesis of ADDRR.  F...

S. Santhosh

Department of Bioinformatics, School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur - 613401, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2127-32

2127-32

1928

869

39.

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF SUCRALFATE AND OXETACAINE IN BULK AND MARKETED FORMULATION BY RP-HPLC

The objective of present study is to develop and validate a method for the estimation of sucralfate and oxetacaine in suspension dosage form. An isocratic reversed phase high performance liquid chromatographic method was developed to estimate sucralfate and oxetacaine using thermohypersil BDS (4.6 x 150mm, 5). The mobile phase was prepared by mixing ammonium acetate (pH- 4.4) and methanol in th...

Sana Ahmed , Iffath Rizwana *, M. Anitha Vani and Syed Abdul Azeez Basha

School of pharmaceutical sciences, JNTU-K, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2133-39

2133-39

7818

4559

40.

CHARACTERIZATION OF FRUCTOSE DIET INDUCED DIABETES MELLITUS IN SWISS ALBINO MICE

Diabetes mellitus is an endocrine disorder, in which a person has high blood sugar, and the body does not produce sufficient insulin, or cells do not act in response to the insulin that is produced. Diabetes mellitus is a complicated metabolic disease that has gravely affected the human health and quality of life. As increase in carbohydrate intake, especially of fructose and high rich diet are bo...

Pramod K. Raghav* and Shilpa Bhargava

Department of Biotechnology and Food Sciences, Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan - 303122, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2140-45

2140-45

2666

785

41.

ISOLATION OF AN ANTI-CARCINOGENIC COMPOUND: MYRICETIN FROM COCHLOSPERMUM RELIGIOSUM

Studies on plant secondary metabolites have been increasing over the last 70 years. These molecules are known to play a major role in the adaptation of plants to their environment, but also represent an important source of active pharmaceuticals. Role of primary metabolites in basic life functions such as cell division and growth, respiration, storage, and reproduction have been described in moder...

Abhavya Pandey*, Alok Sharma and Payal Lodha

Plant Pathology Tissue Culture and Biotechnology Laboratory, Department of Botany, University of Rajasthan, Jaipur-302004, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2146-52

2146-52

2256

1086

42.

ANTIOXIDANT POTENTIAL OF Mn2+ IN THE HUMAN EJACULATED SPERMATOZOA UNDER OXIDATIVE STRESS

Reactive oxygen species (ROS) formation from fertile volunteer donor measured by thiobarbuteric acid reactive substances (TBARS). Spermatozoal suspension was treated or not with nicotine and supplemented or not with Mn2+. The same protocol followed when we used ferrous ascorbate promoter system and calculates the Cmax and kc value of the reaction using Lineweaver-burk double reciprocal plot. For c...

Kuldeep Kaushik *, Pawan Kumar Mittal and Natwar Raj Kalla

Head & Assistant Professor Department of Zoology, Dev Samaj Post Graduate College for Women Ferozepur City, Punjab India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2153-62

2153-62

1999

894

43.

EFFECT OF STANDARDIZED EURYCOMA LONGIFOLIA EXTRACT ON ROSIGLITAZONE METABOLISM IN THE OLD NORMAL MALE RAT HEPATOCYTES: A MECHANISM STUDY

Eurycoma longifolia has been widely used by society as an aphrodisiac especially in Indonesia, Vietnam and Malaysia. However, only few studies have been published related to the herb-drug interaction. Previous study showed that the standardized extract of E. longifolia affected phase I rosiglitazone metabolism especially in the old male rat hepatocytes for both diabetic and normal rats. The presen...

Purwantiningsih*, Abas Hj Hussin and Kit Lam Chan

Department of Pharmacology & Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada University, 55281 Yogyakarta, Indonesia

DOI: 10.13040/IJPSR.0975-8232.6(5).2163-69

2163-69

1568

672

44.

METABOLITE PROFILE OF VARIOUS DEVELOPMENT BREAD FRUIT LEAVES (ARTOCARPUS ALTILIS. PARKINSON. FOSBERG) AND THE IDENTIFICATION OF THEIR MAJOR COMPONENS

Empirically dry fallen of Artocarpus altilis leaves are widely used as a traditional medicine, but the green leaves that have been widely studied. Therefore, this research was conducted to compare the metabolite profile of green leaf, attached yellow, fallen yellow, fallen dry, and fermented green leaves. Comparison of flavonoid content was conduted by HPLC. Extraction was performed using Soxhlet ...

Hesti Riasari *, Sukrasno and Komar Ruslan

Indonesian School of Pharmacy (STFI) Jl. Soekarno-Hatta No.354 (Parakan Resik). Bandung 40266 Indonesia.

DOI: 10.13040/IJPSR.0975-8232.6(5).2170-77

2170-77

2194

1344

45.

PROFILE OF ANTICANCER AND RADICAL SCAVENGING ACTIVITIES OF STEROIDS FROM STEMS OF POLYGONUM PULCHRUM

Five steroids have been isolated and identified from methanol extracts of stems of Polygonumpulchrum (Bambu-bambu, Tolakinese, a South East Sulawesi Ethnic), namely; (1) sigmasta-4, 25-diene-3,6-diol; (2) 6β-hydroxystigmasta-4.22-dien-3-one, (3) stigmasterol, (4) stigmasta-4.22-dien-3-on, and (5) ergosterol peroxide.  The isolation was worked by using chromatography method including thin layer c...

I. Sahidin *, Adi Suwandi , Nohong and Marianti Anggraeni Manggau

Head of Laboratory of Natural Products Chemistry, Faculty of Pharmacy, Halu Oleo University, Kendari 93232 Indonesia

DOI: 10.13040/IJPSR.0975-8232.6(5).2178-84

2178-84

1833

1110

46.

STUDY OF ANTIDEPRESSANT ACTIVITY OF CHRONIC ADMINISTRATION OF TRAMADOL AND WHEN IT IS CO-ADMINISTERED WITH FLUOXETINE IN LOW DOSES IN SWISS ALBINO MICE USING DESPAIR SWIM TEST

Objective- To evaluate the antidepressant activity of chronic administration of Tramadol alone and when combined with Fluoxetine in low doses in albino mice. Methods- The antidepressant effect was determined by recording the immobility time in Despair Swim Test. The mice were randomized into seven groups, with six mice in each group. Group 1 mice were given normal saline (10 ml/kg) which served as...

G. Sirisha *, N. S. Usha and B. Santhamma

Department of Pharmacology, Kamineni Institute of Medical Sciences, Narketpally, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2185-90

2185-2190

1568

612

47.

GREEN CHEMISTRY APPROACH IN SYNTHESIS OF 3,4-DIHYDROPYRIMIDINONE DERIVATIVES UNDER SOLVENT-FREE CONDITIONS

Simplify and improve conditions that have been used traditionally to carry out the conventional Biginelli reactioninvolves three-component one-pot condensation of an aldehyde, β-ketoester and urea or thiourea in ethanol under strong acidic condensation HCl for the synthesis of dihydropyrimidinone(DHPMs) and their sulphur analogue dihydropyrimidinthione derivatives which are act as (antibacterial,...

Tawassl T. H. Hajelsiddig and A. E.M. Saeed*

Department of Chemistry, Collage of Science, Sudan University of Science and Technology, Sudan

DOI: 10.13040/IJPSR.0975-8232.6(5).2191-96

2191-96

7176

1144

48.

COMPARATIVE STUDY OF THE STATUS OF VITAMIN D3 IN YOUNG OFFICE WORKING WOMEN AND HOUSEWIVES IN UDAIPUR, RAJASTHAN

Background: Vitamin D3 deficiency continues to be an unrecognized epidemic in many populations around the world. Vitamin D is important for the absorption of calcium, and bone formation and maintenance. Objective: This study was carried out with an objective of evaluating the prevalence of low Vitamin D levels (insufficiency and deficiency) in female office workers and housewife’s in Geetanjali ...

Neha Sharma, Ketan Mangukiya, K.L. Mali, Umesh kumar Pareek and Avdhesh kumar Sharma

Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2197-00

2197-00

2539

1028

49.

IN-VITRO EFFICACY EVALUATION OF ETHANOLIC EXTRACT OF CINNAMOMUM ZEYLANICUM (CINNAMON) AS POTENTIAL ANTIMICROBIAL AGENT AGAINST CLINICAL ISOLATES

Spices are the potential source of natural products and naturally derived compounds. These compounds show antioxidant, antimicrobial properties. The aim of this study is to evaluate the antimicrobial properties of Cinnamomum zeylanicum (Cinnamon). In this study, antimicrobial activities of 70% ethanolic extracts of Cinnamomum zeylanicum were evaluated against different bacterial strains (E.coli, P...

Rajesh Singh Tomar and Vikas Shrivastava*

Amity Institute of Biotechnology, Amity University, Gwalior-474005, M.P., India

DOI: 10.13040/IJPSR.0975-8232.6(5).2201-04

2201-04

2260

687

50.

PREPARATION AND CHARACTERISATION OF β-CYCLODEXTRIN NEBIVOLOL INCLUSION COMPLEX

Nebivolol HCl (NEB) is antihypertensive drug having β-adrenergic blocking properties. Although NEB is rapidly absorbed after oral administration, it has low bioavailability (12%), due to its low water solubility. The purpose of present work was to enhance the solubility and dissolution rate of NEB by inclusion complexation technology. Complexation is the association between two or more molecules ...

Bhopate Sapana B. * and Dhole Shashikant N.

Department of Pharmaceutics, P. E. S‟s, Modern College of Pharmacy (for ladies), Borhadewadi, Dehu-Alandi Road, A/P Moshi, Tal – Haveli, Dist. Pune – 412 105, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2205-13

2205-2213

6410

1659

51.

CHEMICAL VARIABILITY OF TITHONIA DIVERSIFOLIA (HEMSL.) A. GRAY LEAF AND STEM OIL FROM CÔTE D’IVOIRE

Tithonia diversifolia was collected from 27 localities of Côte d’Ivoire. The oils of the leaves and stems obtained by hydrodistillation using Clevenger-type apparatus have been studied by GC and GC-MS. The identified components accounted for 91.4% - 96.9% of leaves and 93% – 95.6% of stems. The content of the main components varied from sample to sample. α-pinene (0.9 – 47.4%), limonene (0...

Affia B. Florence, Wognin E. Léon and Tonzibo Z. Félix*

Laboratoire de Chimie Organique Biologique, UFR SSMT, Université Félix Houphouët Boigny de Cocody-Abidjan (Côte d’Ivoire), 22 BP 582 Abidjan 22

DOI: 10.13040/IJPSR.0975-8232.6(5).2214-22

2214-22

2294

873

52.

PHARMACOGNOSTICAL STUDIES ON MESUA FERREA, CARICA PAPAYA, ASIMUM SANCTUM AND TRIBULUS TERRESTRIS. IN RAYALASEEMA, A.P.

The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica papaya (Seeds), Asimum sanctum (Leafs) and Tribulus terrestris (Leafs). Fluorescence analysis has been performed and physicochemical characters such as ash values and extractive values have been performed. Prelimin...

N. Raja Naik and P. Indira

Department of Zoology, Sri Krishnadevaraya University, Anantapuramu, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2223-27

2223-27

2508

710

53.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF DOXYCYCLINE MONOHYDRATE AND ORNIDAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM

A simple, rapid, precise, cost effective, stability indicating RP-HPLC method has been developed and validated for the simultaneous estimation of Doxycycline monohydrate (DOXM) and Ornidazole (ORN) in Bulk and pharmaceutical dosage form. The chromatographic separation was achieved on Hypersil BDS C18 column (250mm ×4.6mm, 5μm) using a mobile phase consisting of Buffer : Acetonitrile  (55:45 v/v...

A. Srilekha, P. Pavani and B. Sreedhar*

Inorganic and Physical Chemistry Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad 500607, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(5).2228-39

2228-39

1631

1417