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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 6 (2015) - Issue 8, August

Review Articles

 
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1.

BIOACTIVITY OF MORUS ALBA L. EXTRACTS-AN OVERVIEW

Recently white mulberry has attracted a lot of interest as source of bioactive constituents used in phytopharmacy and in functional food formulation. In practice, active compounds are separated from plant material by extraction process using different solvents and extraction conditions. The most commonly solvents used for extraction are water, ethanol, methanol, acetone, ether and their mixtures. ...

Katarzyna Grajek *, Aleksandra Wawro and Dominika Kokocha

Institute of Natural Fibres and Medicinal Plants, ul. Wojska Polskiego 71b, 60-630 Poznan, Poland

DOI: 10.13040/IJPSR.0975-8232.6(8).3110-22

3110-22

4435

2658

2.

A REVIEW ON ORGANOCHLORINE PESTICIDES AND REPRODUCTIVE TOXICITY IN MALES

Today, humans and wildlife are constantly exposed to thousands of chemical residues, through air, food and water. Organochlorines are widespread pollutants and comprise a variety of compounds containing carbon, hydrogen, and chlorine. Chlorinated insecticides, solvents, and fumigants are widely used around the world. Exposure to organochlorine chemicals has been associated with many deleterious ef...

Aksha Sharma *, Preeti Sharma , Priyanka Sharma and Suresh C. Joshi

Department of Biosciences, Stani Memorial PG College, Mansarovar, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3123-38

3123-38

3698

1370

3.

RESISTANCE AND SENSITIVITY; COMPETITIVE MECHANISMS OF CISPLATIN

In the battle against cancer, platinum drugs have contributed a lot so far but still the prerequisite is to mend their flaws e.g., resistance and reduced sensitivity. In addition to side effects, intrinsic and acquired resistance decreases the effects of cisplatin on cancer cells by lowering the formation of DNA adducts and subsequent DNA damage. Resistance against cisplatin includes; the increase...

Maria Fareed Siddiqui* and Esha Sadiq

Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, 1 km Defense Road Lahore, Pakistan

DOI: 10.13040/IJPSR.0975-8232.6(8).3139-45

3139-45

2284

720

4.

A REVIEW ON EPIDERMAL MANIFESTATION OF PAPPILOMA VIRUS INFECTION IN HUMAN

The Human Papilloma Viruses (HPV) are non-enveloped, small DNA virus, which are responsible for worldwide problem. HPVS can be associated with different varieties of epidermal manifestations. It belongs to the Papovavirus family. On the basis of oncogenic potential these have been classified as high risk and low risk types of virus. Currently histopathological techniques are widely being used as t...

Yashbir Singh, Rashmi Tripathi, Satyavani Guttula* and Sunil Patel

Department of Bioinformatics, Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3146-50

3146-50

2228

770

5.

ENZYMATIC INACTIVATION OF PENICILLINS: AN EMERGING THREAT TO GLOBAL PUBLIC HEALTH

Penicillin antibiotics have been the main-stay armamentarium in the fight against bacterial diseases due to their availability and ease of use. Penicillin resistance has been attributed to modification of penicillin-binding proteins, production of β-lactamases, overexpression of efflux pumps and reduced permeability. In the past 10 years, research was centred on Gram-positive bacteria, particular...

Ukpai A Eze *, Ngozi M Eze and Adam Mustapha

Department of Medical Laboratory Sciences, College of Health Sciences, Ebonyi State University, Abakaliki, Nigeria

DOI: 10.13040/IJPSR.0975-8232.6(8).3151-60

3151-60

2816

904

6.

DEVELOPMENT OF ORALLY ADMINISTERED FIXED DOSE COMBINATION (FDC) PRODUCTS: PHARMACOKINETIC AND BIOPHARMACEUTICAL CONSIDERATIONS

Combination drug therapy has been shown to be beneficial in chronic multifactorial diseases, infectious diseases and in the treatment of comorbid conditions. Some drug combinations have also been developed to improve the bioavailability of the active components by combining with drug metabolizing enzyme inhibitors. Fixed dose combinations (FDC) offer advantages of better efficacy, ease of administ...

Jagannath Kota*, Phaninatha Sarma Ayalavajjala and Rama Sivasubramanian

Global PK/PD, DMPK, Novartis Institutes for BioMedical Research, Novartis Healthcare Pvt. Ltd., Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3161-73

3161-73

4622

1614

7.

IONTOPHORESIS: CONTROLLED TRANSDERMAL DRUG DELIVERY SYSTEM

Currently there has been an increased interest in using iontophoretic technique for the controlled transdermal drug delivery of medicines, especially in the delivery of proteins & peptides through skin membranes. The delivery of ionic drug molecules and peptide/protein molecules through transdermal delivery to attain a systemic therapeutic effect, chemical or physical methods are needed to imp...

N. Kirubakaran *, M. Chandrika and K. Reeta Vijaya Rani

Himalaya Drug Company, Makali, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3174-84

3174-84

2979

710

8.

RIVAROXABAN, A DIRECT FACTOR XA INHIBITOR: A DRUG UPDATE

Warfarin, a vitamin K antagonist has been the leading oral anticoagulant since early 1940s despite limitations like slow onset and offset of action, variations in metabolism, multiple food and drug interactions, narrow therapeutic index and need for routine laboratory monitoring. Rivaroxaban, a direct factor Xa inhibitor is a recently introduced orally effective novel anticoagulant offering improv...

P. D. Shyamasakhi, K. M. Sania *, N. D. Meena, T. Bikram and L. Tarinita

Department of Pharmacology, RIMS, Imphal, Manipur, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3186-91

3186-91

1944

823

9.

MATERNAL MORTALITY: TEN YEARS REVIEW STUDY AT GOA MEDICAL COLLEGE THE ONLY MEDICAL COLLEGE & TEACHING INSTITUTE IN THE STATE OF GOA

Objective: Maternal Mortality: Ten year review study in The Department of Obstetrics and Gynecology, Goa Medical College. Method: A retrospective study was conducted in the Dept. of OBG GMC over a period of10 years spanning between Jan 4 to Dec 13 regarding Maternal Mortality. Results: There were total of 58 deaths out of 54604 live births during this 10 year period giving maternal mortality ratio...

Poonam Tiwari,* Manjusha Jindal and Guruprasad Pednekar

Department of Obstetrics and Gynaecology, Goa Medical College, Goa, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3192-97

3192-97

2033

648

10.

SELF EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

The oral route is easiest and most convenient route for drug administration. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor water solubility. This may leads to higher inter subject and intra subject variability and therapeutic failure. The improvement of compounds solubility and bioavailability are the greatest challenges in formulati...

R. B. Nawale*, P. B. Salunke and A. B. Jadhav

Government College of Pharmacy, Opp. to Government Polytechnic College, Vedant Road, Osmanpura, Aurangabad, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3198-08

3198-08

2324

764

11.

SYNTHESIS OF BIOLOGICALLY IMPORTANT s-TRIAZINE BASED CHALCONES

A new series of s- triazine based chalcones have been synthesized by the temperature controlled reaction. The first substitution occurs at low temperatures (0°C), the second substitution at approximately at room temperature (25-30°C) and the third at elevated temperatures (70-100°C). This property allows substitution of three different neucleophiles onto the same triazine core which provides a ...

Anupama*, Iram Khan and Bhawani Singh

Department of Chemistry, Banasthali Vidyapith, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3209-14

3209-14

2348

1469

Research Articles

 
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12.

PREVENTIVE ANTI-INFLAMMATORY ACTIVITY OF AN AQUEOUS EXTRACT OF LARREA DIVARICATA CAV. AND DIGESTIVE AND HEMATOLOGICAL TOXICITY

Larrea divaricata Cav. commonly known as “jarilla hembra” is used in folklore medicine as anti-inflammatory. There was no scientific evidence justifying the medicinal use of the aqueous extract for inflammation diseases. Nowadays, there are two principal types of anti-inflammatory drugs: Steroidal anti-inflammatory drugs (corticosteroids) and non-steroidal anti-inflammatory drugs (NSAIDs), whi...

Roberto Davicino, Ignacio Peralta , Renzo Martino, Rosario Alonso and Claudia Anesini *

Institute of Chemical and Drug Metabolism, University of Buenos Aires- National Council of Scientific and Technical Research (IQUIMEFA-UBA-CONICET), Buenos Aires, Argentina

DOI: 10.13040/IJPSR.0975-8232.6(8).3215-23

3215-23

2595

818

13.

POTENTIAL ANTI CANCER ACTIVITY OF SNAKE VENOM, BEE VENOM AND THEIR COMPONENTS IN LIVER AND BREAST CARCINOMA

The present study aimed to evaluate the antitumor efficacy of Snake venom (SV), bee venom (BV), combinations of their components and their apoptotic, cell death mechanisms in liver (HepG2) and breast (MCF7) cell lines. Cytotoxic effects of venoms, L-Amino acid oxidase (svLAAO), phospholipase A2(svPLA2), Melittin ( MEL) were tested against HepG2 and MCF-7 cell lines and IC50 was calculated . mRNA e...

Fathia Zaky El Sharkawi *, Shaimaa Saber Saleh and Aly Fahmy Mohamed El Sayed

Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(8).3224-35

3224-35

4494

1359

14.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 1- PHENYL 1-H-PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES

Novel 1- Phenyl 1-H-Pyrazolo[3,4-d]Pyrimidine Derivatives were synthesized from the key intermediate chloro derivative (1).The conversion of chloro derivative(1) into 1,2,4 triazoles, 1,3,4 thiadiazoles and thiazoles was accomplished with the intermediacy of the ester(2) and hydrazide (3). Moreover triazole ring was annelated to the pyrazolopyrmidine core in two step reaction involving reaction wi...

Samy M. Ibrahim, M. Abou-Kul, Moustafa K. Soltan, and Ahmed M. El-Sayed

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(8).3236-44

3236-44

2257

850

15.

MICRO-ELECTROPHORETIC MOBILITY STUDY OF THE INFLUENCE OF CHLORPROMAZINE HYDROCHLORIDE ON DIMYRSTOYLPHOSPHATIDYLCHOLINE LIPOSOMES IN DIFFERENT MEDIA

In this study, the possible influence of the model, cationic drug chlorpromazine hydrochloride (CPZ-HCl) concentration on the micro-electrophoretic mobility of neutral large multi-lamellar dimyrstoylphosphatidylcholine (DMPC) liposomes was investigated in various media at both 25oC and 37oC. In addition the effect CPZ-HCl concentration on the micro-electrophoretic mobility of both positively charg...

Farah Hamad Farah

Department of Pharmaceutics, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, Ajman PO Box 346, United Arab Emirates.

DOI: 10.13040/IJPSR.0975-8232.6(8).3245-53

3245-53

2054

868

16.

EFFECTS OF CRUDE EXTRACT OF KHAT (CATHA EDULIS) ON LIVER FUNCTION IN RATS

Introduction: Khat is chewed traditionally in Ethiopia, Somalia, Yemen and Kenya. In Ethiopia, khat chewing is now becoming an every-day substance of abuse for the general population regardless of its adverse effects on human health. Therefore, this study was conducted to investigate the effects of crude extract of khat fresh leaves and soft twigs on liver function in rats. Methods: Adult male Wis...

Tesso Gemechis *, M. K. C. Menon , N. Gnanasekaran and Seifu Daneil

Department of Medicine, School of Medicine, Dire-Dawa University, Dire Dawa, Ethiopia

DOI: 10.13040/IJPSR.0975-8232.6(8).3254-59

3254-59

2523

909

17.

EFFECT OF PROCESS PARAMETERS OF MICROWAVE ASSISTED EXTRACTION (MAE) ON NATURAL PRODUCT YIELD FROM ONION PEEL

Globally, more than 30 % of the onion peels arises at the retail and purchaser levels, of which the post-harvest and dealing out level wastages report for the major share. So, studies on the characterization of unutilized fractions of the onion peels specify their potential candidature for reprocessing. Maximum preservation of these phytochemicals during extraction requires optimised process param...

Shaileyee Das* and Subhash C Mandal

Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3260-75

3260-75

2555

617

18.

ANTIMICROBIAL ACTIVITY OF AQUEOUS AND ETHANOL EXTRACTS OF VIOLET PLANT (SECURIDACA LONGIPEDUNCULATA FRES) ON TESTED PATHOGENIC BACTERIA

This study was undertaken to investigate the antimicrobial activities of aqueous and ethanol extracts of violet plant, Securideca longepedunculata leaves and root bark extracts against the pathogenic bacteria isolates of Salmonella typhi, Escherichia coli and Pseudomonas aeroginosa. Disc diffusion method was used for antibacterial testing and Tetracycline drug at 250 mg/ml concentration was used a...

J. Sanusi , A. Bawa Jibia *, J. Yahaya Runka , S. Liadi , A. Ahmad Abubakar and Rabi’u Sani Zurmi

Department of Biological Sciences, Federal University Dutsin-ma, Katsina State Nigeria

DOI: 10.13040/IJPSR.0975-8232.6(8).3276-84

3276-84

2725

705

19.

FORMULATION AND EVALUATION OF SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR IMPROVED ORAL DELIVERY OF OLMESARTAN MEDOXOMIL

The present work aimed at formulating a solid self micro emulsifying drug delivery system (solid-SMEDDS) for Olmesartan Medoxomil with the objective of improving the aqueous solubility, dissolution and oral delivery of the drug. Liquid SMEDDS of the drug were formulated using Capmul MCM as the oil phase, Tween 80 and Phenoxide HCO-40 as the combined surfactants after screening various vehicles. Th...

S. S. Bakhle *and J. G. Avari

Pharmaceutics Division, Department of Pharmaceutical Sciences, R.T.M Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3285-98

3285-98

2159

807

20.

PRELIMINARY PHYTOCHEMICAL ANALYSIS AND IN-VITRO HYPOGLYCEMIC POTENTIAL OF NILGIRIANTHUS CILIATUS NEES

Objective: The present study was aimed to investigate the phytochemical analysis and inhibitory activity of Nilgirianthus ciliatus Nees against the carbohydrate hydrolyzing enzymes. Methods: The Nilgirianthus ciliatus plant powder was extracted with ethanol by cold maceration technique. Primary and secondary metabolites present in the plant extract were identified by means of phytochemical screeni...

K. Kavitha, K.Sujatha*, S.Manoharan and Sundara Ramaprabhu

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3299-05

3299-05

2088

897

21.

QUALITY IMPROVEMENT OF FRESH-CUT-FRUITS BY GAMMA RADIATION FOR IMMUNE-COMPROMISED PATIENTS

Objective: Immune-compromised patients are vulnerable to microbes, which are usually safe and sound for healthy individuals. The aim of this study is to provide a quality fresh fruits such as apple, grape, guava, pear and plum for immune-compromised personnel sing different doses of gamma radiation. Methods: Irradiation impacts on microbial number, in treated fruits were assessed and compared to s...

S. Mahmud , Md. M. Alam *, A. Ansari , Md. M. Rahman, Md. K. Alam and Md. K. Pramanik

Aging Division, Institute of Development , Aging and Cancer (IDAC), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai , Japan

DOI: 10.13040/IJPSR.0975-8232.6(8).3306-13

3306-13

1815

585

22.

CONSUMER PROPERTIES OF TRANSDERMAL PATCHES AND THEIR USE IN MODERN PHARMACOTHERAPY

In today's hectic lifestyle, such dosage form as plaster, attracts more attention of scientists and gives new opportunities to use it in medicine. The purpose of our study was to investigate consumer properties of transdermal patches, hold the commodity analysis of the dosage form and determine the prospectiveness of their use in modern pharmacotherapy. Market review has been conducted. Analyzed t...

T. V. Diadiun *, I.I. Baranova , S.V. Stepanenko and M.V. Nikitina

Commodity Science Department , National University of Pharmacy, Kharkov, Ukraine

DOI: 10.13040/IJPSR.0975-8232.6(8).3314-20

3314-20

1723

518

23.

BIOCHEMICAL, HEMATOLOGICAL AND HISTOLOGICAL CHANGES IN RESPONSE TO GRADED DOSE OF EXTRACT OF EQUISETUM ARVENSE IN ADULT FEMALE WISTAR RATS

Equisetum arvense, commonly known as field horsetail, is a perennial herb belonging to the genus Equisetum. Traditionally, Equisetum arvense is used as diuretic; anticoagulant, skin antiseptic, in kidney and liver related problems and gastric ulcers. E. arvense has also been suggested for the treatment of bone related disorders such as osteoporosis but the data is very scarce on its dose range and...

S. Badole and S. Kotwal *

University Department of Biochemistry, RTM Nagpur University, Amravati road, Nagpur, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3321-26

3321-26

2256

656

24.

A SHORT TERM PROSPECTIVE, INTERVENTIONAL, COMPARATIVE CLINICAL STUDY FOR EVALUATION OF RAMIPRIL VERSUS TELMISARTAN IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS

Aim: To comparatively evaluate the antihypertensive efficacy and tolerability of ramipril and telmisartan in stage 1 hypertensive diabetic patients. Material and Methods: This short term, prospective, randomized, interventional, comparative clinical study was conducted amongst 53 patients of stage 1 hypertension with type 2 diabetes (27 ramipril and 26 telmisartan patients), aged 30 years and abov...

Pankaj Kumar , A. K. Kapoor *, H. K. Singh and M. Kulshrestha

Department of Pharmacology, Rohilkhand Medical College & Hospital, Bareilly (U.P.), India

DOI: 10.13040/IJPSR.0975-8232.6(8).3327-33

3327-33

1788

567

25.

EVALUATION OF ANTIDIABETIC POTENTIAL OF METHANOLIC EXTRACT OF BENINCASA HISPIDA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

The number of patients with Diabetes mellitus is increasing rapidly both in developed and developing countries around the world. The existing medications especially synthetic drugs often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate one such herbal extra...

Abhishek Mahatma , Abhijit Sonowal * and M Santhosh Kumar

Department of Pharmacology, Nargund college of Pharmacy , Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3334-43

3334-43

2278

706

26.

STUDY ON ANTIMICROBIAL POTENTIAL AND PRELIMINARY PHYTOCHEMICAL SCREENING OF LAWSONIA INERMIS LINN.

The disease causing bacteria have evolved the genetic ability to transmit and acquire resistance to drugs used as therapeutic agents. The discovery of antibiotics to combat these pathogens marked a resolution in the 20th century. Unfortunately, because of the inappropriate use of antibiotics in human and veterinary medicine, certain strains of bacteria and fungi developed the ability to produce su...

P. R. Dahake * and S. I. Kamble

Department of Seed Technology and Department of Botany, Phulsing Naik Mahavidyalaya Pusad, District Yavatmal, Maharashtra State, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3344-50

3344-50

2004

921

27.

BIOLOGICAL INVESTIGATIONS OF THE LEAF EXTRACT OF SPONDIAS PINNATA

The present study was done to evaluate in-vitro membrane stabilizing activity with human RBC, in-vivo neuropharmacological activity including open field and swimming test, gastrointestinal motility and acute toxicity of different leaf extracts of Spondias pinnata in Swiss albino mice following oral administration. In-vivo GI motility test was done by charcoal induced anti motility test, acute toxi...

S. Kamal, R. Akhter, N. Akter Tithi, Md. A. Wadud, S. N. Narjish, Md. Shahriar and M. A. Bhuiyan*

Phytochemistry Research Laboratory, Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(8).3351-58

3351-58

3543

652

28.

PREPARATION AND EVALUATION OF CONTROLLED RELEASE OF BETAXOLOL HYDROCHLORIDE OCULAR INSERTS

The present work focuses on treatment of glaucoma by formulating ocular inserts of different polymeric combination and Betaxolol to enhance therapeutic effect through prolonging contact time with corneal surface, Betaxolol is a cardio selective (β1 adrenergic) receptor blocking agent. Ophthalmic betaxolol may be especially useful in the treatment of glaucoma in patient with pulmonary disease. Sus...

K. B. Kulkarni *, Patil Ajaykumar , Nagoba Shivappa N. and S. S. Ladde

Channabasweshwar Pharmacy College *, Latur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3359-74

3359-74

1682

651

29.

GC-MS ANALYSIS OF BIOACTIVE COMPOUNDS IN BRYONOPSIS LACINIOSA FRUIT EXTRACT

The bioactive components of Bryonopsis laciniosa fruits have been evaluated using GC/MS. The chemical compositions of the methanolic extract of Bryonopsis laciniosa fruits were investigated using Perkin-Elmer Gas Chromatography –Mass Spectrometry, while the mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology (NIST) library. The G...

B. Ramya , T. Malarvili * and S. Velavan

Department of Biochemistry , Rajah Serfoji Govt. College Autonomous, Thanjavur , TN, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3375-79

3375-79

1881

965

30.

DEVELOPMENT AND IN-VITRO EVALUATION OF CHLORHEXIDINE AND FLURBIPROFEN HARD CANDY LOZENGES

The mouth of human body provides non-shedding surfaces (teeth) for natural microbial colonization. This can result in the accumulation of large masses of bacteria and their products at stagnant sites. Dental plaque, Periodontitis and gingivitis are some of this type of conditions, which can develop due to microbial accumulation on teeth and Infections of    throat leading to tonsillitis, pharyn...

Renuka Pothu *, Adella Aparna and Y. Madhusudan Rao

Department of Pharmaceutics, Vaagdevi College of pharmacy , Kishanpura, Warangal, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3380-90

3380-90

2257

788

31.

EFFECT OF AQUEOUS LEAF EXTRACT OF TRIDAX PROCUMBENS ON BLOOD COAGULATION

The effect of aqueous leaf extract of Tridax procumbens on blood coagulation was investigated in order to verify the claim that the said extract can be used to manage bleeding. This was done by examining the effect of the extract on bleeding time, the effect of graded amounts of the extract on clotting time as well as the effect of the heat-treated extract on bleeding time. These were performed us...

C.O. Ikese *, Z.C. Okoye , D.T. Kukwa, S.O. Adoga and J. L. Lenka

Benue State University Makurdi *, Department of Chemistry, Makurdi, Nigeria

DOI: 10.13040/IJPSR.0975-8232.6(8).3391-95

3391-95

2540

843

32.

EFFICIENCY OF DIFFERENT SOLVENTS ON PHYTOCHEMISTRY PROFILE OF WATER MELON (CITRULLUS VULGARIS SCHRAD.) SEED EXTRACTS

Citrullus vulgaris Schrad. has occupied a popular place in the indigenous system of folk medicine because of its high nutritional and antioxidant properties. The study aims to elucidate the extractive yield percentage and screen the seed extracts of watermelon using different solvents for its phytochemical profile. The solvents selected were Methanol, Ethanol, Chloroform, Petroleum ether, Ethyl ac...

M. Angeline Christie Hannah and S. Krishnakumari *

Department of Biochemistry, Kongunadu arts and science college, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3396-00

3396-00

1719

734

33.

LIPOPOLYSACCHARIDE (LPS) AND MURAMYL DIPEPTIDE (MDP) INDUCED CHRONIC LIVER INJURY IN HIGH FAT DIET FED RAT–A POSSIBLE MODEL FOR NON ALCOHOLIC FATTY LIVER DISEASE

Liver defend the PAMPs or DAMPs via regulation of innate immunity through modulation of “TOLL LIKE RECEPTORS and NOD LIKE RECEPTORS” A breakdown of tolerance may induce in appropriate immune response leads to acute and chronic liver diseases like NASH/NAFLD thus considered as disorders of immune response. HFD is itself a basic component for generating metabolic disorders and major source for f...

T. Dubey * and M. R. Chorawala

K.B. Institute of Pharmaceutical Education and Research, Gandhinagar Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3401-11

3401-11

1393

574

34.

THE QUALITY ASSESSMENT OF ONCOLOGICAL PAIN MANAGEMENT CLINICAL TRIALS IN THE CONTEXT OF A LIMITED NUMBER OF META-ANALYSIS OF OPIOID FORMULATIONS

Treatment ofcancer painis mainly based on the use of opioidanalgesics.This study includes opioids commonly used in Polish clinical practice, such as: dihydrocodeine, tramadol, buprenorphine, morphine, fentanyl, oxycodone and methadone. The purpose of our research is performing a quality assessment of the available clinical trials concerning opioids efficacy and an evaluation of the cause of the li...

W. Giermaziak *, Ż. Bondaryk , A Markowska and T Faluta

Main Medical Library, Chocimska Street ,Warsaw, Poland

DOI: 10.13040/IJPSR.0975-8232.6(8).3412-23

3412-23

1738

772

35.

SYNTHESIS, CHARACTERIZATION AND STUDY OF ANTIMICROBIAL ACTIVITY OF 2-HYDROXY 3-NITRO-5-METHYL-N-(SUBSTITUTED PHENYL) CHALCONE IMINES

Chalcones and its derivatives show various biological activities. The present study deals with the synthesis of series of 2-hydroxy-3-nitro-5-methyl–N-substituted phenyl chalcone imines from 2-hydroxy-3-nitro-5-methylphenyl chalcone and different substituted aromatic animes in ethanol in presence of 2, 3 drops of Conc. H2SO4. Structures of synthesized compounds have been established by spectral ...

S. B. Borul * and S. V. Agarkar

Department of Chemistry, Late Ku. Durga K. Banmeru Science College, Lonar, Dist- Buldana (M.S.) India

DOI: 10.13040/IJPSR.0975-8232.6(8).3424-27

3424-27

1529

673

36.

STABILITY INDICATING ISOCRATIC RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR INDAPAMIDE AND PERINDOPRIL ERBUMINE IN PURE AND ITS COMBINED TABLET DOSAGE FORM

A reverse phase liquid chromatography method (RP-HPLC) was developed to estimate the amount of Indapmide and Perindopril in bulk and its pharmaceutical formulations. A Waters Alliance HPLC system equipped with auto sampler, UV-Visible detector and YMC Column (150 x 4.6mm, 3µ particle size) were used for the quantification of the drugs. Separation was carried out by using potassium dihydrogen phos...

B. Siva Sai kiran, G. Raveendra Babu *, M. Venkta Kumari and G. Vijaya Kumar

Department of Pharmaceutical Analysis , Alluri Krishna Rao and Govindamma College of Pharmacy, Nallajerla, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3428-38

3428-38

2150

1016

37.

DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR VENLAFAXINE HYDROCHLORIDE AS BILAYER TABLET

Present research work aims to develop venlafaxine hydrochloride gastro retentive tablets for prolonged release and increased gastric retention time. Venlafaxine is an antidepressant of the serotonin nor- epinephrine reuptake inhibitor (SNRI) class. Bioavailability is 45% following oral administration and half life is 5 hours. To study the effect of formulation variables on drug release and buoyan...

Krishana Dongre, A.S. Pratapwar * and D.M. Sakarkar

Sudhakarrao Naik Institute of Pharmacy, Pusad, Dist: Yavatmal, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3439-53

3439-53

1830

817

38.

PHYTOCHEMICAL AND ANTIOXIDANT STUDIES OF JUSTICIA GENDARUSSA BURM. F. AN ETHNOMEDICINAL PLANT

Present investigation deals with the phytochemical and antioxidant studies of Justicia gendarussa Burm.f. (family Acanthaceae), a  medicinally important herb. Biochemical studies highlighted that in leaf tissue, quantities of soluble carbohydrate, amino acid and ascorbic acid are of 307 mg/g, 34.93 mg/g and 619µg/g, respectively. In stem bark, quantities of soluble carbohydrate, amino acid and a...

Kumaresh Pal and Chowdhury Habibur Rahaman*

Department of Botany, Visva-Bharati University, Santiniketan- 731235, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3454-62

3454-62

3218

806

39.

NUTRITIONAL VALUE OF SKELETONEMA COSTATUM (CLEVE, 1873) FROM PARANGIPETTAI, SOUTHEAST COAST OF INDIA

Present aim to study the biochemical composition, i.e., protein, carbohydrate, lipid, ash, amino acids, fatty acids, vitamins, minerals and Carbon, Hydrogen, Nitrogen from Skeletonema costatum. The biomass of marine diatom (S.costatum) were collected from Parangipettai, Southeast cost of India. The lyophilized powder of S.costatum was used for biochemical analysis. The results of proximate composi...

C. Santhosh Kumar and V. Ashok Prabu *

CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, Tamilnadu -India

DOI: 10.13040/IJPSR.0975-8232.6(8).3463-66

3463-66

2051

1315

40.

QUALITY OF LIFE OF DIABETIC PATIENTS ON DIFFERENT TYPES OF ANTIDIABETIC MEDICATIONS

Diabetes mellitus (DM) was found to impair all dimensions of health except mental health and pain and in a more recent multinational study, DM was found to have a notable impact on general health, measured using the Medical Outcomes Short-Form 36 (SF-36).  A cross-sectional, randomized study conducted in Ajman and Sharjah, October 2012 to May 2013, using a self-completed questionnaire and SF-36 h...

S. Shanableh*, A. Abdulkarem, Md. Shamssain, Z. Metwali and F. Sarhan

Clinical Pharmacy and Pharmacy Practice Department, Pharmacy College, Ajman University of Science and Technology Network, Ajman, United Arab Emirates

DOI: 10.13040/IJPSR.0975-8232.6(8).3467-72

3467-72

1723

637

41.

ACUTE DERMAL IRRITATION STUDY OF POLYHERBAL GEL MASTILEP IN RABBITS

Objective: The current study was designed to study Acute Dermal Irritation potential of Mastilep gel (supplied by M/S Ayurvet Limited, Baddi, India) according to OECD guidelines. Materials and Methods: Mastilep gel, a new herbal ointment for topical use applied on the udder, has been developed as an alternative method for controlling mastitis in ruminants. Mastilep gel’s active ingredients inclu...

M. M. Gatne, K. Tambe, Adarsh * and K. Ravikanth

Department of Pharmacology and Toxicology, Bombay Veterinary College, Parel, Mumbai (M.S.) India

DOI: 10.13040/IJPSR.0975-8232.6(8).3473-77

3473-76

1754

942

42.

IN-VITRO STUDIES ON OIL DEGRADING BACTERIA ISOLATED FROM OIL CONTAMINATED SOIL OF VANIYAMBADI AND AMBUR AREAS OF VELLORE DISTRICT

The oil polluted soil has many hydrocarbons which can be degraded by microbes. These oil degrading microbes were isolated from the oil contaminated soil through plate and dilution technique. The oil contaminated soils were collected from the oil spilled places of Vaniyambadi and Ambur areas of Vellore District, Tamil nadu, India. Through the biochemical tests, the isolated bacterial strains were i...

K. Malathi * and V. Prabha

Department of Biochemistry, D.K.M College for Women, Vellore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3478-83

3478-83

1415

616

43.

CASSIA TORA SEEDS EXTRACT REGULATES LIPID METABOLISM IN ALLOXAN INDUCED DIABETIC RATS

The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in alloxan-induced diabetic rats. In this model oral administration of seed extract (500 mg/kg bw.P.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal of  serum levels of total cholesterol, phospholipids, triglycer...

V. Kumar *, F. Mahdi , R. Singh, A. Ali Mahdi , K. Jawad , R. K. Singh and M. Singh

Department of Biochemistry , Era’s Lucknow Medical College & Hospital Lucknow, U.P., India

DOI: 10.13040/IJPSR.0975-8232.6(8).3484-89

3484-89

1780

524

44.

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME NEW 6-(3,5-SUBSTITUTED-2-BROMO/HYDROXY PHENYL)-1,2,4-TRIAZINE DERIVATIVES AS ANTICONVULSANT AGENTS

6-(2-Amino-3,5-substituted phenyl)-1,2,4-triazines were prepared by refluxing semicarbazones or thiosemicarbazones in presence of sodium hydroxide solution. 6-(3,5-Substituted-2-bromophenyl)-1,2,4-triazine derivatives and 6-(3,5-substituted-2-hydroxyphenyl)-1,2,4-triazine derivatives were prepared from 6-(2-amino-3,5-substituted phenyl)-1,2,4-triazine derivatives by sodium nitrite, hydrobromic aci...

Rajeev Kumar , Anita Singh * and Ram Kumar Roy

Department of Pharmacy, Kumaun University, Bhimtal, Nainital, Uttarakhand, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3490-00

3490-00

1592

660

45.

FORMULATION AND CHARACTERIZATION OF CONTROLLED RELEASE BIOADHESIVE NANOPARTICLES ENCAPSULATED WITH NEOSTIGMINE BROMIDE

In the recent days targeted drug delivery has gained more prominence for various advantages like site specific delivery and controlled release from the formulations. Amongst the plethora of avenues explored for targeted drug delivery, bioadhesive nanoparticles backed foremost attention offering local drug delivery and controlled drug release solving problems like tissue damage and drug wastage. Fo...

Venkatesh Gavini*, Srinivasa Rao Konijeti and T. Siva Nagaraju

Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3501-10

3501-10

1843

817

46.

SYSTEMATIC STUDY OF TAMRA (COPPER) BHASMA PREPARED BY TRADITIONAL AYURVEDA METHOD

Bhasmas, the formulations, which can be prepared from metals, minerals or even some marine products, are being used in Ayurvedic system of medicine. Copper (Tamra) is one such metal, used to prepare a bhasma, called “Tamra Bhasma” (TB) which is claimed to cure various diseased conditions. Though bhasmas are prepared since centuries, the exact mechanism of conversion of metal to its bhasma, esp...

H. Sutar , M. Tembhurne , A. Bhave , B. Shrikhande , S. Sathaye , A. Gaikwad , K. Patil , and S. Kulkarni *

Center for Materials Characterization, National Chemical Laboratory, Pune, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3511-20

3511-20

3691

1091

47.

IMMUNOMODULATORY POTENTIAL OF A POLYHERBAL PREPARATION FOLLOWING ACTIVATION OF MURINE MACROPHAGES

Five medicinal plants used in the traditional medicine of India, were selected for studying their immunomodulatory potential through the activation of macrophages, individually and in synergism. The plants were Boswellia serrata Roxb., Curcuma longa L., Glycyrrhiza glabra L., Tribulusterrestris L., and Tylophora indica (Burm f.) Merr. In the present study, strong stimulation of antigen specific an...

Kavita Chahal *, NitinNema and N. P. Shukla

Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3521-27

3521-27

1480

508

48.

ANTIPYRETIC ACTIVITY OF CRUDE AND AQUEOUS EXTRACT OF GULE GHAAFIS (GENTIANA OLIVIERI GRISEB) ON YEAST INDUCED PYREXIA IN ANIMAL MODEL

Ghaafis (Gentiana olivieri Griseb) has been recommended in Classical Unani literature as an important ingredient of many antipyretic formulations. Singularly, it is advocated in both crude and extract form. The present study was conducted to investigate the antipyretic activity of crude and aqueous extract of Gule Ghaafis on yeast induced pyrexia in animal model. The study was carried out by the m...

Mohammad Asim Khan *, Abdul Wadud , Mohd Tariq , MD Nazamuddin

Department of Ilmul Advia (Pharmacology) *, National Institute of Unani Medicine, Kottigepalya, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3528-33

3528-33

1655

599

49.

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ASPIRIN AND LANSOPRAZOLE IN BULK AND LABORATORY SAMPLE BY DIFFERENT UV SPECTROPHOTOMETRIC TECHNIQUES

Four simple, rapid, inexpensive, precise and accurate UV spectrophotometric methods have been developed for simultaneous estimation of Aspirin (ASP) and Lansoprazole (LANSO). Method A was Simultaneous equation method (Vierodt’s method) which applies measurement of absorptivities at two wavelengths, 276.00 nm, (λmax of Aspirin) and 284.00 nm, (λmax of Lansoprazole) in zero order spectra. The co...

S. Fanse and S. Rajput*

Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3534-43

3534-43

2822

1050

50.

CLINICAL OUTCOME STUDY OF CRITICALLY-ILL SEPTIC PATIENTS GIVEN TAURINE SUPPLEMENTED ENTERAL NUTRITION

Background: Sepsis is a significant public health concern and is the main cause of death in surgical intensive care units (ICUs). Patients with sepsis have features consistent with immunosuppression. Taurine is rapidly emerging as one of the more interesting amines which has been reported to have immune-modulatory effect through its action on cytokines. Purpose: To determine the effect of using Im...

E.M. Elmokadem *, N.A. Sabri, T.A. Roshdy and A. M. Hasanin

Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(8).3544-53

3544-53

2053

663

51.

INVESTIGATION ON IN VITRO CYTOTOXIC ACTIVITY OF A SELECTED WILD CUCURBITACEAE PLANT CORALLOCARPUS EPIGEAUS AGAINST CANCER

Medicinal plants have been investigated for possible anti-cancer effects. Corallocarpus epigaeus (Roth & willd.) cl. is an ethnobotanically important wild climber that belongs to the family Cucurbitaceae. The aim of the present study is to examine the cytotoxic activity of Corallocarpus epigaeus (Roth & willd.) cl., on two tumor cell lines. The methanolic root extract of the plant Coralloc...

M. B. Bhavani* and S. Leelavathi

DOS in Botany, University of Mysore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3554-57

3554-57

2285

844

52.

IN VITRO AND IN VIVO CHARACTERIZATION OF GLIMEPIRIDE MICROPARTICLES

In the present investigation, controlled release microparticles of Glimepiride were prepared by emulsion solvent evaporation technique using cellulose acetate as release retardant polymer. The microparticles were evaluated for In-Vitro release study and In-Vivo evaluation. The microparticles were subjected to In-vitro release studies by employing 7.8 pH phosphate buffer as dissolution medium. The ...

Balagani Pavan Kumar *, Irisappan Sarath Chandiran and Korlakunta Narasimha Jayaveera

Department of Pharmaceutics, Gokula Krishna College of Pharmacy, Sullurpet, A.P, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3558-62

3558-62

1653

765

53.

DIVERSITY OF MOLLUSCAN FAUNA FROM FRESHWATER BODIES OF SANGLI DISTRICT: A COMPREHENSIVE STUDY IN RELATION TO ENVIRONMENTAL VARIABLES

Molluscs as a second largest phyla includes snails, slugs, clams, oysters, scallops, cuttlefish, squid and octopus. Present study revealed, diversity of molluscan fauna from three sites i.e Khanderajuri lake, Mhaishal lake and Krishna river in the period of January, 2011 to December, 2013. Among collected molluscs 10 species were identified from seven families i.e. Physidae, Lymnaeidae, Viviparida...

A. B. Sarwade , S. K. Pati and N.A. Kamble *

Department of Zoology, Shivaji University, Kolhapur -, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3563-70

3563-70

2138

885

54.

SOLID LIPID NANOPARTICLES BASED GEL FOR TOPICAL DELIVERY OF ANTIFUNGAL AGENT

The aim of present work was to develop and evaluate solid lipid nanoparticles (SLNs) based gel for topical delivery of antifungal agent. Bifonazole (BFZ) is an imidazole antifungal agent having broad spectrum activity against dermatophytes, moulds, yeasts, fungi and some gram positive bacteria. BFZ SLNs systems were developed by melt emulsification followed by ultrasonication technique using Preci...

Harshal Garse*, Pramod Jagtap and Vilasrao Kadam

Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, Sector-08, CBD Belapur, Navi Mumbai- 400614, Maharashtra, India.

DOI: DOI: 10.13040/IJPSR.0975-8232.6(8).3571-79

3571-79

2607

1044

55.

IMPROVING THE PERFORMANCE OF PHARMACEUTICAL TABLET PRODUCTION USING SIX SIGMA METHODOLOGY (MODULATION ON DIGESTIVE ENZYME TABLET)

Each company is expected to develop specifications for their products to be accommodated with the inspection guide of pharmaceutical quality control. After product analysis for (X) pharmaceutical company it was noticed that 84.5% of defects were attributed to tablet department while 14.1% and 1.4% for ampoule and syrup departments respectively so it was valuable to solve the tablet department prob...

El-Menhawy A., Mohamed N. M. , Arafa H. A. , and Abd Elmonem A. R *

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Misr University for Science and Technology, 6 October, Giza, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(8).3580-93

3580-93

2595

803

56.

METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF TINIDAZOLE BY REVERSE PHASE HPLC TECHNIQUE

The aim of the current study is to develop a simple, specific, rapid and precise quantification technique for the estimation of tinidazole from tablet dosage form. Successful separation of the drug was carried out on a C18 column (particle size 5 µm, 250 mm length × 4 mm i.d.) using a mobile phase consisting of a 5.3 mM phosphate buffer solution and acetonitrile in the ratio of 60:40 (v/v). The ...

Amit Kumar De , Ashok Kumar Bera and Biswajit Pal*

Department of Chemistry , St. Paul’s C. M. College, Kolkata, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3594-98

3594-98

1853

604

57.

ISOLATION AND IDENTIFICATION OF L-ASPARAGINASE PRODUCING SALINICOCCUS SP. M KJ997975 FROM SOIL MICROBIAL FLORA

L-asparaginase is responsible for the hydrolysis of L-asparagine into L-aspartic acid and ammonia. L-asparaginase is used as an effective therapeutic agent against lymphocytic leukemia. It also finds applications in food industry. Though much has been unraveled about LA, it may appears today that it is at the tip of iceberg and there is tremendous scope in screening of novel LA sources and studyin...

M. R. Bhat, J. S. Nair and T. Marar*

School of Biotechnology and Bioinformatics, D.Y. Patil University, CBD Belapur, Navi Mumbai, MS, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3599-05

3599-05

3331

1059

58.

EFFECT OF NOVEL BENZISOXAZOLE DERIVATIVES AGAINST EHRLICH ASCITES CARCINOMA CELLS IN SWISS ALBINO MICE: CYTOTOXIC AND HAEMATALOGICAL STUDIES

The present study is to investigate the cytotoxicity properties and haematological indices of synthesized molecules (S1-S4) in comparison to the standard drug 5 fluorouracil which reflects the anticancer potentials of the above molecules. Cytotoxicity studies were performed by in vitro MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyl teterazolium bromide) assay. Haematological studies were done b...

Sharath Chandra S. P. * and Vishwaprakash Mahadimane P.

Department of Biochemistry *, Government Science College, Hassan, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3606-11

3606-11

1354

496

59.

HPLC-ELSD DETERMINATION OF SODIUM LAURYL SULPHATE AND POLYSORBATE IN NEBIVOLOL DRUG PRODUCT AND DIFFERENT FORMULATION PRODUCTS

The contents of Sodium lauryl sulphate (SLS) and Polysorbate (Tween 80) were studied in different formulations of Nebivolol film coated tablets. The contents were extracted using the diluent Methanol: Water in the ratio 60:40 v/v and analyzed in HPLC coupled with Evaporative light scattering detector (ELSD). SLS and Tween 80 are solubilizing agents and the amount of these contents are critical in ...

V. Durga Prasad *, V. Rangareddy , P. Aparna , K. Sudheer babu and N. N. Prasad

AET Laboratories Pvt Ltd., Kazipally Industrial area, Medak district, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3612-16

3612-16

6303

2242

60.

INVESTIGATIONS ON ANTI-DIABETIC MEDICINAL PLANTS USED BY TRIBES OF WAYANAD DISTRICT, KERALA

The present study aims to explore the ethnomedicinal knowledge of the plants and their preparations used to cure diabetes by the tribes of Mananthavady, Bathery and Vythiri taluks of Wayanad district, Kerala. Preparation of ethnomedicine using various plant parts and other information related to tribes associated; habitat, habit and status of medicinal plants recorded are highlighted. Documentatio...

M. P. Raghavendra *, A. G. Devi Prasad and T. B. Shyma

Postgraduate Department of Microbiology *, Maharani’s Science College for Women, JLB Road, Mysore 570 005, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3617-25

3617-25

3979

1376

61.

BACOPAMONNIERA, A NOOTROPIC HERB ALLEVIATES ABNORMAL MOLECULAR AND IMMUNOHISTOCHEMICAL CHANGES EVOKED BY CHRONIC EXPOSURE OF METHYLMERCURY IN RAT CEREBELLUM

Methylmercury (MeHg), a highly toxic environmental pollutant, induces oxidative stress and dysfunction in many cell types. Bacopa monniera is a perennial herb, and is used as a nerve tonic in ayurveda, a traditional medicinal system in India. This study was aimed to evaluate the effect of Bacopa monniera extract (BME) on MeHg-induced toxicity in rat cerebellum. Male Wistar rats were administered w...

Johnson Christinal and Thangarajan Sumathi*

Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai , Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(8).3626-33

3626-33

1455

458

62.

ANTIHYPERCHOLESTROLEMIC POTENTIAL OF OMEGA-3-FATTY ACID CONCENTRATE IN ALLOXAN INDUCED DIABETIC RODENT

Exhaustive study of scientific literature provides the initial evidence that omega-3-fatty acids the principal component of fish oil is responsible for exerting important biological effects when administered to population at risk of coronary heart diseases and diabetes mellitus. The main reason behind the study was to evaluate the anti-atherogenic properties of marine lipids in alloxan induced dia...

Debashree Das , Anand Chaurasia , Prashant Sahu , Vikash K Mishra and Sushil K Kashaw *

Department of Pharmacology, Dr. Hari Singh Gour, Sagar, M. P,, India

DOI: 10.13040/IJPSR.0975-8232.6(8). 3634-40

3634-40

1498

419