Volume 11 (2020) - Issue 6, June
Review Articles
AN UPDATED REVIEW ON INVASIVE NATURE, PHYTOCHEMICAL EVALUATION, & PHARMACOLOGICAL ACTIVITY OF AGERATINA ADENOPHORA
Ageratina adenophora, often known as Crofton Weed, is one of the common invasive weeds which first originated from Mexico and Central America and gradually invaded numerous parts of the world. Because of its ability to alter the soil microbial communities and its allelopathic competition with other plant species, this plant colonizes forest margins, stream banks and disturbed areas in large dense ...
4845
2020
A REVIEW ON DOXORUBICIN INDUCED CARDIOTOXICITY AND ITS MOLECULAR MECHANISM
Doxorubicin (DOX), an anthracycline antibiotic that is highly used for cancer treatment (chemotherapy), but its chemotherapeutic application is limited due to its cardiotoxicity. The major mechanism of doxorubicin action as the free radical formation and as an inhibiter of topoisomerase II and other signaling pathways is also invoked significant consequence for the cardiomyocyte. But the years of ...
1446
756
PIM-1 KINASE: A NOVEL TARGET FOR CANCER CHEMOTHERAPY- A REVIEW
Cancer is the major cause of mortality in most of the developing countries. Recent times have seen an exceptional advancement in cancer biology Research. Researchers undertook the development of enormous chemotherapeutic agents. Pim family of serine/threonine kinases regulated by calcium/calmodulin have been identified as unique molecular targets in oncogenesis. It constitutes three members: Pim-1...
3534
1804
SCREENING MODELS OF LAXATIVE ACTIVITY
Substances that loose stools and boost bowel movements are laxatives, purgatives, or aperitives. They are used to treat constipation and to stop it. Constipation relates to infrequent or difficult to transfer bowel movements. Often the stool is hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if the bowel movement has not been fully passed. Hemorrhoid's anal fissur...
5401
1889
A REVIEW ON RECENT TRENDS AND FUTURE PERSPECTIVES OF IONTOPHORESIS ASSISTED OCULAR DRUG DELIVERY
Iontophoresis assisted drug delivery system refers to a novel system for delivery of the drug in a non-invasive and effective manner across the skin or biological membranes by electrical assistance. Drug substances exhibiting low trans-corneal (ocular) permeability can be effectively delivered in a safe, fast, and painless manner by the employment of electric current of low intensity, which enhanc...
2865
1124
AN OLD ADAGE MANAGEMENT PERSPECTIVE FOR DANDRUFF
Dandruff is a well-known and global consumer problem, characterized by flaking and scaling of the scalp, with itching and irritation. Although it is not a life-threatening disease, but it is directly related to individual self-esteem, confidence, and beauty. Approximately half of the population is suffering from dandruff and expending around billions of dollars, including hospital services and cou...
1792
951
NANOPHYTOSOMES AN IMPERATIVE TECHNOLOGY FOR ENHANCING THE BIOAVAILABILITY OF BIOACTIVE CONSTITUENTS
Herbal medicine has been widely accepted as a promising approach for the treatment of various diseases with lower cost and minimized toxicity. Bioactive constituents isolated from the herbal source are equipped with synthetic drugs. The potency of any herbal medication is contingent on the delivery of the effectual level of the therapeutically active constituent. The integration of a novel drug de...
2359
1127
RECENT FRONTIERS IN SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW
Oral route has always been the preferred route of drug administration in many diseases. This route is limited to those drugs molecules that are permeable across the gastric mucosa and are sparingly soluble. Solubility is an important parameter to achieve the desired concentration of drug in systemic circulation for therapeutic response. As a consequence of modern drug discovery techniques, there h...
2158
1267
PROSTATE CANCER: RISK FACTORS, SCREENING, DIAGNOSIS AND TREATMENT
Prostate cancer is one of the most important cancer in men. In most cases, prostate cancer confirmed by histological and transrectal biopsy for the examination of prostatic tissue. Metastatic prostate cancer is second leading cause of death from cancer. Androgen deprivation therapy is common treatment in men with prostate cancer that may cause fatigue, increased body fatness, and loss of lean body...
1682
978
A REVIEW ON TRANSLATIONAL PERSPECTIVE AND EFFICACY OF DIFFERENT ENGINEERED THERAPEUTIC ANTIBODIES
From bench to bedside, clinical research had always played as a convenient tool in the field of cancer biology to inquire about the effectiveness of different anticancer drugs on different human-derived cancer cell lines. According to the American Cancer Society, nearly 4000 new cases and 1600 deaths predicted in 2019 in the United States. Besides, to these alarming statistics, rising cost and hea...
1411
644
PRODUCTION AND PURIFICATION STRATEGIES FOR LACCASE
Laccase belongs to polyphenol oxidases, which is a very wide family of copper-containing atoms in the center, which serves as the catalytic site. It is biochemically a glycoprotein with molecular mass being between 50kda to 130kda and 30% carbohydrate content, in addition to this it has three types of copper atoms. It is one of the most important enzymes due to its role in the food industry. It ac...
3026
1045
EUDRAGIT: A VERSATILE AND ROBUST PLATFORM
In many aspects, polymeric materials have a pre-eminent position among excipients as they form the backbone of modern pharmaceutical formulations and drug delivery technologies in particular. A polymer is a natural, semi-synthetic or synthetic substance that is combined with a drug or other active pharmaceutical ingredient or excipient to release the drug in a pre-programmed manner. The drug deliv...
5536
2463
NANOEMULSION: A PROMISING AND NOVEL NANOTHERAPEUTIC VEHICLE FOR TRANSDERMAL DRUG DELIVERY
Transdermal delivery of therapeutics has been identified by scientific researchers as an alternative choice of drug administration, owing to its unique and tremendous benefit over conventional and oral administrations, but its exploration has been limited because of the “skin barricade” as its major challenge. A special formulation that is capable of meeting up and overcoming its associated ch...
1789
762
MEDICINAL SIGNIFICANCE OF BENZIMIDAZOLE ANALOGUES: A REVIEW
Benzimidazoles are well known biologically active N-containing heterocycles, widely used as drugs such as antifungal, antibacterial, antiparasitic, and antihelmintic. In addition, N1 and C2-substituted benzimidazoles and their derivatives have been found to be potent biologically active compounds as well. Further, N1-substituted benzimidazoles have exhibited anti-microbial, antihelmintic activitie...
2365
806
Research Articles
ANTIPSORIATIC EFFECTS OF CLOBETASOL LOADED SOLID LIPID NANOPARTICLES ON IMIQUIMOD INDUCED PSORIASIS IN BALB/C MICE
The aim of the current investigation was to prepare and investigate the potential of Clobetasol (CP) loaded solid lipid nanoparticles based gel (SLN-gel) for the dermal delivery and to evaluate its anti-psoriatic efficacy by comparing with conventional ointment formulation. This study will provide an insight into the use of nanocarriers, esp. SLNs loaded with CP for the effective treatment of psor...
2505
896
PRELIMINARY PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS FOR IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM ABUTILON FRUTICOSUM GUILL AND PERR. A RARE AND ENDEMIC PLANT OF INDIAN THAR DESERT
Present work was aimed to determine, identify, and characterize the bioactive chemical compounds from methanolic leaves extract of Abutilon fruticosum by GC-MS analysis. Fresh disease-free leaves were collected shade dried and powdered for extraction with HPLC grade methanol. Preliminary phytochemical screening of methanolic leaves extract was performed using standard methods to determine the pres...
2342
1822
IN-VIVO EFFECT OF WITHACOAGULIN AND COAGULIN C ISOLATED FROM WITHANIA COAGULANS DUNAL FRUITS ON BLOOD PRESSURE OF ALBINO RATS
The present study was designed to evaluate the in vivo effect of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits on blood pressure of albino rats. DOCA (10 mg/kg; i.p.) along with diet high in sodium chloride salt was used to induce hypertension in rats. Comparative effects of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits were observed. Femal...
2042
809
STRUCTURAL ELUCIDATION OF CHITOSAN BASED HETEROCYCLIC COMPOUNDS OF ANTI-MICROBIAL AND ANTI-CANCER ACTIVITY
Schiff bases from chitosan and 5-nitro salicylaldehyde-aniline complexes represented the important structural subject in excess of biologically active molecules, including synthetic. The introduction of 5-nitro salicylaldehyde at C-2 nitrogen position and aniline at C-6 oxygen position of chitosan. The structure-activity relationship (SAR) of the double Schiff based chitosan, synthesized from the ...
2002
845
FORMULATION AND EVALUATION OF FEBUXOSTAT FAST DISSOLVING TABLETS USING STERCULIA FOETIDA SEED STARCH AS EXCIPIENT BY LYOPHILIZATION TECHNIQUE
The present work is focused on the formulation of Febuxostat fast dissolving tablets by lyophilization technique using natural starch extracted from Sterculia foetida seeds. Starches were extracted using the alkali method, i.e., sodium hydroxide at 0.1%, 0.25%, and 0.5% concentrations and water from Sterculia foetida seed powder. These starches were evaluated for phytochemical and physicochemical ...
2440
974
DEVELOPMENT OF STABILITY INDICATING HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF TENELIGLIPTIN AND METFORMIN: APPLICATION TO ALKALINE DEGRADATION KINETIC STUDY
Stability indicating the HPTLC method was developed for simultaneous estimation of teneligliptin and metformin by using aluminum plates precoated with silica gel 60 F224 (Merck) and mobile phase toluene: methanol: GAA: TEA (5:4:0.5:0.5) with scanning wavelength of 257 nm. The developed method was validated for linearity, stability, accuracy, precision, robustness, LOD and LOQ as per ICH guidelines...
1623
680
DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF NANOCRYSTALS OF NITROFURANTOIN
Nitrofurantoin is a broad-spectrum bactericidal antibiotic that affects both gram-negative and gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein, and cell wall synthesis. Nanocrystals of NFT were prepared by a cold high-pressure homogenization technique. To improve the dissolution rate, the drug was formulated in...
1944
959
STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF INOTUZUMAB OZOGAMICIN IN BULK DRUG AND INJECTION DOSAGE FORM
A simple, rapid, accurate, precise, and reproducible stability indicating RP-HPLC method for the estimation of Inotuzumab Ozogamicin in bulk and injection dosage form was developed and validated as per ICH guidelines. The separation was done using BDS C18 150 × 4.6 mm, 5 µ column. The mobile phase (Water and Acetonitrile 55:45% v/v) was pumped at 1.0 ml/min, and effluent was detected at 240 nm u...
1481
627
ANTIOXIDANT, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF DIFFERENT FRACTIONS FROM METHANOLIC EXTRACT OF PSIDIUM GUAJAVA L. LEAVES
Psidium guajava Linn. the most popular and widely cultivated fruiting plant all over Bangladesh. The present study was aimed to investigate the antioxidant, analgesic and antimicrobial activities of n-hexane (HPG), chloroform (CLPG) and ethyl acetate fractions (ET APG) obtained from methanol extract of Psidium guajava (MPG) leaves. The in-vitro antioxidant activity of fractions HPG, CLPG and ET AP...
1963
675
FORMULATION AND EVALUATION OF NOVEL SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM OF SUMATRIPTAN SUCCINATE
In migraine disease which is an autoimmune disorder, 5-HT1 receptor agonist like Sumatriptan succinate (STS) is widely used. Its bioavailability is 15-17% due to extensive presystemic metabolism. The objective of this work was to prepare Sumatriptan succinate (STS) in a self nanoemulsifying drug delivery system (SNEDDS) and then convert it into solid-SNEDDS (S-SNEDDS) via extrusion/spheronization ...
1949
804
PREPARATION AND CHARACTERIZATION OF FLOATING ALGINATE BEADS OF LAFUTIDINE AS A GASTRORETENTIVE DOSAGE FORM
Background: Lafutidine floating beads as a gastro-retentive dosage form antagonisms of histamine H2 receptor. It is used as anti-ulcerative agent. It is effective against the oesophageal lesions induced by acid reflux through inhibition of acid secretions. Objectives: The objective of the present work was to formulate and evaluate the floating beads of Lafutidine as a model drug. The objective of ...
1922
1068
DESIGN AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF HERBAL DRUG COMPOUND
A glycyrrhetinic acid isolated from herbal plant Glycyrrhiza glabra (family Fabaceae), commonly known as licorice is used to formulate microemulsion as a self-emulsifying drug delivery system for oral administration using almond oil as the oil phase. Pseudoternary phase diagrams were constructed to determine the microemulsion existence region using surfactant (Tween 80) and co-surfactant (propylen...
1599
830
EVALUATION OF AMELIORATIVE EFFECT OF SYZYGIUM CUMINI LEAVES ON ULCERATIVE COLITIS
Ulcerative colitis is a subtype of Inflammatory Bowel Disease. The leaves of Syzygium cumini belonging to the family Myrtaceae were selected to evaluate its efficacy in ameliorating the acetic acid-induced Ulcerative colitis. Male albino Wistar rats were randomly divided into five groups. Group 1 was given the vehicle tween 80, group II received 2 ml of 4% acetic acid solution on 8th day intrarect...
1804
670
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL N-(BENZOXAZOL-2-YL)-2-(2-OXOINDOLIN-3-YLIDINE) HYDRAZINE CARBOTHIOAMIDES
In view of the biological prominence of the benzoxazole derivatives as well as, isatin derivatives, it was planned to synthesize some novel N-(Benzoxazol-2-yl)-2-(2-oxoindolin-3-ylidine) hydrazine carbothioamides (VI) as such reports were not available in the literature and were screened for antibacterial, antifungal and anti-mycobacterial activity. Fourteen new compounds were synthesized by conde...
1603
719
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IVABRADINE AND METOPROLOL IN TABLET DOSAGE FORM
The objective of the method is to develop a rapid, simple, accurate, precise RP-HPLC method for the simultaneous estimation of Ivabradine and Metoprolol in tablet dosage form. The analytes were run through BDS C18 150 × 46 mm, 5µm column, and detected at a wavelength of 260 nm using PDA 996 (photodiode array) detector. Mobile phase containing buffer 0.01N disodium hydrogen phosphate (3.5±1 pH) ...
2091
745
FORMULATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF LORNOXICAM
The aim of the present study was to develop a controlled release formulation of Lornoxicam to maintain constant therapeutic levels of the drug for over 12 h. Guar gum, xantham gum, and carbopol 934 were employed as polymers. All the formulations were passed various physicochemical evaluation parameters, and they were found to be within limits. From the dissolution studies, it was evident that the ...
1604
767
PHARMACOKINETIC DRUG INTERACTIONS BETWEEN HMG-COA REDUCTASE INHIBITORS PITAVASTATIN WITH CONCOMITANTLY USED TICAGRELOR
In the present research, the pharmacokinetic Drug-drug interactions between HMG-COA reductase inhibitors Pitavastatin with concomitantly used Ticagrelor have been studied. Pitavastatin is a member of the blood cholesterol lowering medication class of statins while Ticagrelor is a platelet aggregation inhibitor. Combination therapy with statins and other cardiovascular medications is recommended fo...
1416
659
CLONAL MICROPROPAGATION OF THREATENED MORINGA CONCANENSIS NIMMO (MORINGACEAE): SUSTAINABLE ALTERNATIVE
Moringa is one of the medicinally important genera and Moringa concanensis Nimmo is a threatened species of it. Clonal micropropagation has been used to produce true to type multiple copies and help to conserve a number of plants. A comprehensive micro-propagation protocol has been developed in the present study. It was found that Murashige and Skoog (1962) (MS) basal elements enriched with 0.05 m...
1477
709
REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SEPARATION AND ESTIMATION OF IMPURITIES PRESENT IN PHARMACEUTICAL FORMULATION OF CANAGLIFOZIN
Canagliflozin is sodium-glucose co-transporter-2 inhibitors work by inhibiting SGLT2 to prevent reabsorption of glucose and facilitate its excretion in urine. Impurities in pharmaceuticals which are unwanted chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during stability testing, or develop during formulation or upon aging of both API and formulation. The prese...
1429
739
STUDY ON QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES (IBD): IMPACT OF SOCIODEMOGRAPHIC FACTORS
Introduction: an Inflammatory bowel disease is a group of chronic intestinal diseases characterized by inflammation of the bowel, the large or small intestine. The common types of inflammatory bowel disease (IBD) are ulcerative colitis UC and Cohn’s disease CD. Among the Asian countries, India is subjected to have one of the highest disease burdens of IBD across the globe. The number of IBD case...
1953
713
RELATIVE STRUCTURAL ANALYSIS OF LytTR DOMAIN OF AgrA PROTEIN INVOLVED IN BACTERIAL QUORUM SENSING
Resistance to antimicrobials by pathogenic bacteria is a global menace. An attractive pathway to resolve this problem of resistance may be achieved by targeting the bacterial quorum sensing (QS) process. Fighting bacterial infections by interfering with their command language and disrupting virulence expression could serve as a viable alternative. One of the current strategies is to attenuate viru...
1403
723
IN-VITRO EVALUATION OF ANTIOXIDANT ACTIVITIES OF OLDENLANDIA CORYMBOSA L. (SYN. HEDYOTIS CORYMBOSA) FRACTIONATED EXTRACTS IN VARIOUS SOLVENTS
Antioxidants are the substance having the potential to quench free radicals and significantly delay or inhibit oxidation of the substrate, thus protect biological systems against potentially harmful effects of free radicals; in low concentrations. The present study was aimed to evaluate the in-vitro antioxidant activity of Oldenlandia corymbosa L., a locally available medicinal plant of Assam, use...
1818
937
PHARMACEUTICAL STUDY OF STEROIDAL COMPOUNDS AND ESSENTIAL OIL COMPONENTS OF SENECIO VULGARIS LINN. GROWN IN IRAQ
Objective: Senecio vulgaris Linn. generally known as common groundsel, known in Iraq as Sheikh Al-Rabeeor Al-Kurresa, which is widely distributed in the south and middle parts of Iraq. There was no systemic study in the literature regarding the phytoconstituents that are present in Iraqi’s Senecio vulgaris Linn. Thus, the present study was aimed to examine the presence of some biologically impor...
1619
758
ESTIMATION OF PHYTOCHEMICAL CHARACTERISTICS AND ANTIOXIDANT PROPERTY OF SECONDARY METABOLITES OF A MEMORY ENHANCING MEDICINAL HERB BACCOPA MONNIERI OF EAST KOLKATA WETLAND
Herbal medicine nowadays offers several options to modify the progress and symptoms of medicines. There has been a new trend in the preparation and marketing of drugs based on medicinal plants and their scientific and commercial significance. These plant-derived products are carefully standardized and their efficacy and safety for a specific application have been demonstrated. The objective of thi...
2213
905
PREFORMULATION STUDY FOR CANDESARTAN CILEXETIL BUCCAL (EFFERVESCENT) TABLET
Candesartan cilexetil is a novel, potent, and highly selective non-peptide angiotensin II type 1 receptor blocker. It is a hydrophobic drug that belongs to the BCS Class II drug. For enhancement, the bioavailability and quick systemic action of Candesartan cilexetil a novel formulation of buccal (effervescent) tablet, was designed. Preformulation is an important step in the rational formulation ...
2250
913
ISOLATION AND CHARACTERIZATION OF PHYTOSTEROLS FROM DIEFFENBACHIA AMOENA LEAF EXTRACT
Dieffenbachia amoena is a house plant and known dumb cane. The study was performed based on isolation and structure elucidation of phytosterols from the extract of this plant. The CH3OH crude extract was loaded over the silica gel (60-120 mesh) column, using the stepwise gradient C6H6, CH3OAc, CH3OH. The fractions were further purified by preparative TLC (GF254) to yield compound (1). Compound (1)...
1971
822
THERAPEUTIC AND PREVENTIVE ROLE OF FUNCTIONAL FOODS IN PROCESS OF NEURODEGENERATION
Diet and dietary habits of an individual are considered to be an essential factor based on biologically active compounds extracted or modified from either known or unknown natural sources, contributing to completing the dietary and nutritional needs beyond the traditional supplements. Moreover, the latest research information about their supportive and therapeutic utility suggests that they play a...
2578
724
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROFILE OF EPLERENONE BY LIQUISOLID COMPACTS USING NOVEL EXCIPIENTS
Eplerenone is a poorly soluble drug that belongs to class II biopharmaceutical classification system. It is a selective aldosterone receptor antagonist, which binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreases the sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure and used in congestive heart failure...
2027
854
SOLID DOSAGE FORM DEVELOPMENT OF DABIGATRAN ETEXILATE MESYLATE WITH INCREASED SOLUBILITY AND DISSOLUTION USING COCRYSTALLIZATION
Dabigatran Etexilate Mesylate (DEM), an anticoagulant used to treat and prevent blood clots and to inhibit the occurrence of stroke in people with cardiac arrhythmia. The purpose of this study was to obtain DEM co-crystals by screening eight different conformers and prepare the co-crystals by evaporation technique. Molecular docking was used to identify suitable coformer. Tartaric acid DEM co-crys...
2187
1046
FORMULATION AND EVALUATION OF A pH DEPENDENT MULTI-PARTICULATE COLON TARGETED DRUG DELIVERY SYSTEM USING POWDER LAYERING TECHNOLOGY OF KETOPROFEN
Multiparticulates consist of discrete, small, multiple unit systems of active pharmaceutical ingredients exhibiting the desired drug release pattern. The present work is concerned with the formulation and evaluation of a pH-dependent multiparticulate colon targeted drug delivery system of ketoprofen, a well established anti-inflammatory drug used in the management of inflammatory bowel disease. Th...
2090
977
TRENDS IN ANTIEPILEPTIC DRUGS PRESCRIPTION PATTERN AMONG PATIENTS VISITING A TERTIARY CARE CENTER
The objectives were to observe the drug pattern of epileptic patients with their seizure type, to analyze the type of therapy received by the patients, to observe if epileptic patients are receiving an appropriate dose, to identify the side effects in epileptic patients associated with drug treatment and to observe the cost of conventional and newer antiepileptic drugs (AED’s). This was a cross-...
2503
803
DESIGN, SYNTHESIS AND EVALUATION OF ANTI TUBERCULAR ACTIVITY OF NOVEL TRIAZOLE DERIVATIVES
Substituted triazoles have received considerable attention during the last two decades as they are endowed with a variety of biological activities and have a wide range of therapeutic properties. The present work is concerned with the synthesis of fused 1, 2, 4-triazole derivatives with the objective of discovering novel and potent anti-tubercular agents that might be devoid of harmful side effect...
1802
877
EVALUATION OF PHYTOCHEMICAL COMPOSITION AND ANTI-OXIDANT POTENTIAL OF ANDROGRAPHIS SERPYLLIFOLIA (VAHL) WIGHT: AN ENDEMIC ANTI-OPHIDIC PLANT
In folk medicine, especially in developing countries, several plant species are employed for the treatment of snakebites that lack prompt access to serum therapy. Andrographis serpyllifolia (Vahl), belonging to Acanthaceae, has been recorded in ethnobotanical archives as a plant possessing potent anti-ophidic activity for snake bites. The present study emphasis to investigate the phytochemical pro...
1596
763
FORMULATION AND EVALUATION OF FIXED DOSE COMBINATION OF ATORVASTATIN CALCIUM AND AMLODIPINE BESYLATE IMMEDIATE RELEASE FILM-COATED TABLETS
The present research work was envisaged to develop immediate release film-coated tablets of a fixed-dose combination of Atorvastatin calcium and Amlodipine besylate used to treat the hyperlipidemia, angina pectoris, atherosclerosis, hypertension and symptoms of cardiac risk. Additionally, fixed-dose combination therapy of both drugs tends to provide a synergetic effect and reduce the pill burden. ...
2554
942
CULTURED MYCELIA OF PADDY STRAW MUSHROOM, VOLVARIELLA VOLVACEA (BULL: FR) SINGER PROTECTS WISTAR RATS FORM ACETAMINOPHEN-INDUCED HEPATOTOXICITY
Even though numerous herbal preparations have been recommended in alternative systems of medicine against hepatic disorders, many of them cause severe toxicity upon prolonged use. Volvariella volvacea (Bull.: Fr.) Singer is a highly nutritious mushroom that can be incorporated into the regular diet without the fear of side effects. The protective effect of the aqueous ethanol extract of V. volvace...
1357
647
A PROSPECTIVE STUDY ON EFFICACY OF TRIMETAZIDINE AND ISOSORBIDE DINITRATE IN CORONARY ARTERY DISEASE
Background: The aim of this prospective study was to observe the efficacy of Trimetazidine (TMZ) and Isosorbide dinitrate (ISDN) in Coronary Artery Disease (CAD). Through inhibition of cardiac fatty acid oxidation, trimetazidine strengthens the treatment of CAD, by relieving aggravation; enhancing heart function, essential to prevent heart failure and other serious complications. Methods: 120 pati...
4386
814
DEVELOPMENT OF ANALYTICAL METHOD AND VALIDATION OF NADOLOLIN PURE AND PHARMACEUTICAL FORMULATIONS USING UV-SPECTROPHOTOMETRY AND SPECTROFLUORIMETRY
The development of analytical methods is in need for the estimation of drugs in pure and different pharmaceutical formulations. A simple, sensitive, rapid, accurate, precise and economic spectrophotometric and spectro-fluorimetric method was developed and validated for Nadolol in pure and pharmaceutical formulations. The proposed method was validated according to the International Conference on Ha...
1516
641
FORMULATION AND EVALUATION OF FEXOFENADINE HYDROCHLORIDE LOADED CHITOSAN NANOPARTICLES FOR TREATMENT OF SKIN ALLERGY
An attempt was made to formulate and evaluate Fexofenadine HCl loaded chitosan nanoparticles using biodegradable polymers such as chitosan and sodium tripolyphosphate as a crosslinker in different ratio and proportions. In this formulation, Fexofenadine HCl was selected because of wide range of its use in treatment of skin allergy in the form of coated tablet and pediatric suspension. Different fo...
2513
1085
FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF VERAPAMIL HYDROCHLORIDE
Verapamil hydrochloride is a water-soluble drug, so it is suitable to develop controlled porosity osmotic pump. As Verapamil HCl is a short-acting drug, so developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need for laser drilling, and economical, all of which made the proced...
2485
1043
COMPARATIVE GROWTH ANALYSIS OF CYANOBACTERIA FROM DIVERSE HABITATS WITH REFERENCE TO PIGMENTS
Cyanobacteria are a gram-negative group of microorganisms with unique features and found in diverse conditions of the environment. These tiny bio-factories are rich in pigment molecules like chlorophylls, carotenoids and phycobiliproteins. Studies on physiological and biochemical characteristics of different cyanobacterial strains will not only help to determine their biotechnological potential bu...
1673
734
ASSESSMENT OF THE AWARENESS LEVELS TOWARDS VITAMIN D CHECK, MEDICATION AND RELATED DISORDERS
Background: Vitamin D deficiency and its associated disorders are prevalent in Saudi Arabia. This study aimed to assess the awareness levels towards vitamin D, check, medication, and related disorders. Methodology: In this cross-sectional study, a total of 500 Saudi volunteers living in the city of Hail (A region in Northern Saudi Arabia) and surrounding towns were included during the period from ...
1511
584
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF FAMOTIDINE WITH HYDROPHILIC POLYMERS BY SOLID DISPERSION TECHNIQUE
Objective: In the present study to enhance solubility and in vitro dissolution of poorly aqueous soluble drug Famotidine by preparing solid dispersions using the Kneading method. Methods: Solid dispersions of the drug were prepared by the kneading method using Kollidon and Povidone K30 (as a carrier). Eight different drugs: Carrier ratios were prepared by Factorial design taking three factors, i.e...
2238
1052
SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF PERACETIC ACID AND THE COEXISTENT HYDROGEN PEROXIDE USING CARBOSITALL ROTATION ELECTRODE
The aim of the present work is to determine the feasibility of peracetic acid (PAA) and the coexistent hydrogen peroxide (HP) simultaneous quantitative determination in disinfectant solution by voltammetry using carbositall rotation electrode (CE) as indicating electrode. It has been experimentally proved that the optimum pH for analysis is approximately 3.6. The linear relationship has been obse...
1537
749
SYNTHESIS, CHARACTERISATION OF IMPURITY PRESENT IN THE MANUFACTURE OF LOPRAZOLAM AND STUDY OF IMPURITY PROFILE BY HPLC
The reaction of 5- (2- chlorophenyl)- 7- nitro- 3H- 1, 4-benzodiazepin-2-thione (I) with glycine (A) by means of Na2CO3 in refluxing ethanol in water gives 2-carboxymethylamino-7-nitro-5-(2-chlorophenyl)-3H-1, 4-benzodiazepine(II), which is cyclized by means of dicyclohexylcarbodiimide in methylene chloride to afford 8-nitro-(2-chlorophenyl)-1,2-dihydro-1H,4H-imidazo[1, 2-a] [1, 4]benzodiazepin-1-...
2548
1323
DEVELOPMENT OF FLOATING DRUG DELIVERY SYSTEM FOR LORATADINE: IN-VITRO AND IN-VIVO EVALUATION
The reason for this exploration was to develop gastro-retentive drug delivery systems (GRDDS) of loratadine (LTD) to lengthen the gastric residence time (GRT) by using different polymers like hydroxypropyl methyl celluloses (i.e., HPMC K4 M, HPMC K15 M, HPMCK 100 M), xanthan gum and other excipients such as microcrystalline cellulose (MCC), sodium bicarbonate (NaHCO3), magnesium stearate. All LTD ...
2015
1075
NEUROPROTECTIVE EFFECT OF LEUCASASPERA IN STREPTOZOTOCIN INDUCED ALZHEIMER RAT MODEL
The present investigation deals with the assessment of neuroprotective effect Leucasa spera in streptozotocin (STZ) induced Alzheimer’s disease (AD) in rats. AD was induced by administering STZ (3 mg/kg, ICV) on day one and 3rd day after surgery. Surgery was performed on anesthetized rats with the help of the stereotaxic apparatus. STZ induced AD rats were treated with ethanolic extract of Leuca...
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PRELIMINARY PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF METHANOLIC LEAF EXTRACT OF TEPHROSIA FALCIFORMIS RAMASWAMI FROM INDIAN THAR DESERT
Present study was conducted to identify and characterize the phytoconstituents of methanolic extract of leaves of Tephrosia falciformis (Pers.) Ramaswami of family Fabaceae. The methanolic extract of leaves was subjected to qualitative screening for primary and secondary metabolites as per standard methods; further GC-MS analysis was carried out for the identification of secondary metabolites. The...
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