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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 6 (2015) - Issue 6, June

Review Articles

 
Title
Views
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1.

STRESS DEGRADATION BEHAVIOR OF PREGABALIN, IDENTIFICATION OF DEGRADATION IMPURITIES AND DEVELOPMENT OF STABILITY INDICATING UPLC METHOD

A novel, high-throughput, reverse phase-ultra performance liquid chromatographic (RP-UPLC) method has been developed for the quantification of Pregabalin and its related impurities in drug substance. The stability-indicating capability of the developed method is demonstrated using forced degradation samples from stress conditions such as hydrolysis, oxidation, thermal and photolytic degradation. T...

Pallavi Vukkum*, J.Moses Babu and R.Muralikrishna

Analytical Research, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2241-57

2241-57

12049

5060

2.

POLY-GLUTAMIC ACID (PGA) – STRUCTURE, SYNTHESIS, GENOMIC ORGANIZATION AND ITS APPLICATION: A REVIEW

Mankind has been exploring many new dimensions and techniques to obtain the most feasible and cost effective biopolymers. Biopolymers are the 21st century polymers and are in great demand as they are very easy to produce through the microbial partners and their conglomeration. Future is all about the emancipation of higher finesse quality products with an iota of eco-friendliness. Biodegradation a...

I. N. Najar and S. Das*

Department of Microbiology, School of Life Sciences, Sikkim University, 6th Mile, Samdur, Tadong, Gangtok, Sikkim , India

DOI: 10.13040/IJPSR.0975-8232.6(6).2258-80

2258-80

8880

2155

3.

AYURVEDIC ASPECT OF BACTERIA AND BACTERIAL FOOD POISONING

Bacterial Food Poisoning' is a common name given to predominantly gastro-intestinal infections which arise after the consumption of food or drink that is contaminated with disease-causing bacteria. Over 250 organisms are known to cause food borne illnesses. Ayurveda is an ancient medical science & has described the food poisoning indirectly in the form of Anna Vishaktata. The aims of present s...

Savita Saini* and Sharad Maroti Porte

National Institute of Ayurveda, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2281-90

2281-2290

4174

1357

4.

SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PYRAZOLONES: A REVIEW

Heterocyclic compounds are acquiring more importance in recent years because of their pharmacological activities. Pyrazolones have a particular value due to their broad spectrum of biological activity and their wide ranging utility as synthetic tools in the design of various bioactive molecules. Pyrazolone is a five membered lactum ring, containing two nitrogen and one ketonic group in its structu...

Poonam Gupta*, Jitendra K. Gupta and A. K. Halve

School of studies in Chemistry, Jiwaji University, Gwalior-474011, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2291-10

2291-10

6293

2575

5.

CARBONIC ANHYDRASES: NOVEL TARGETS FOR ANTICANCER DRUGS

Carbonic anhydrases (CAs, EC 4.2.1.1), are a superfamily of metalloenzymes in higher vertebrates, including humans. Sixteen distinct isoenzymes of CA are known to exist in mammals and most of these isoenzymes have been extensively investigated in terms of their biochemical properties, tissue distribution, and genetic control. There are cytosolic isozymes (CA I, CA II, CA III, CA VII and CA XIII), ...

S. Dhande* and M. Gursahani

Bharati Vidyapeeth’s College of Pharmacy, Sector-08, C.B.D. Belapur, Navi Mumbai, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2311-15

2311-15

2424

802

Research Articles

 
Title
Views
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Cited
6.

DEVELOPMENT AND CHARACTERIZATION OF INNOVATIVE LIQUID SALT BASED FORMULATIONS OF SPARINGLY SOLUBLE DRUGS

As a result of tremendous efforts in past few decades, various techniques have been developed in order to resolve solubility issues. However, majority of these techniques offer benefits associated with certain drawbacks; majorly including low drug loading, physical instability on storage and excessive use of environmentally challenging organic solvents. Hence, current effort was to develop an eco-...

Anant A. Patel and Rutesh H. Dave*

Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Division of Pharmaceutical Sciences, Long Island University, Brooklyn, NY, USA

DOI: 10.13040/IJPSR.0975-8232.6(6).2316-27

2316-27

2170

930

7.

VALIDATION AND CHARACTERIZATION OF NANOPARTICLES AUNPS AND AUNPS-LAN CONJUGATE FOR CAPILLARY ELECTROPHORESIS

The Ooctapéptido (LAN: 3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide (2 → 7) disulphide acetate, angiopeptin acetate) cyclic covered gold nanoparticles (AuNPs) results in a complex (AuNPs-LAN) when reacted following the aqueous synthesis using Turkevich method for preparing colloidal gold nanoparticles followed by reaction of conjugat...

E.M. Molina-Trinidad*, O. Estévez-Hernández, A. Salas-Casas , A. Cruz-Castañeda , J. A. Ariza-Ortega , P. Pliego-Pastrana

Medicine Academic Area, Healthy Sciences Institute. Autonomous University of Hidalgo State. Tilcuautla, Hidalgo. Mexico

DOI: 10.13040/IJPSR.0975-8232.6(6).2328-38

2328-2338

2926

1089

8.

EX-VIVO PENETRATION OF NANOMETRIC ZnO and TiO2 ACROSS ACTINICALLY DAMAGED PORCINE SKIN: DEVELOPMENT OF AN ALBINISTIC SKIN PROTECTION TREATMENT

The skin penetration and safety of nanometric zinc oxide and titanium dioxide incorporated in a cosmeceutical cream, specifically designed to retard skin actinic damage in tropical Oculocutaneous albinism was investigated ex-vivo through simulated actinically damaged porcine skin. Franz diffusion cells were used in an experiment modeled in line with related work done by Diembeck et al (1999); the ...

J. Chifamba *, A. Dube and C. C. Maponga

College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe

DOI: 10.13040/IJPSR.0975-8232.6(6).2339-48

2339-48

1759

688

9.

ANTIMICROBIAL ACTIVITY OF SECONDARY METABOLITES PRODUCED BY ENDOPHYTIC FUNGI ISOLATED FROM STEMS OF JATI TREE (TECTONAGRANDIS L.F)

Diaporthephaseolorum is endophytic fungi isolated from Jatitree (Tectonagrandis L.f).  Endophytic microbes were microbes that spent part or all of their life live within plant tissue of a host plant.  They produce secondary metabolites with potent anti microbial activity.  Jatitree (Tectonagrandis L.f) was one of herbal plants that act as host plants for endophytic microbes that produce seconda...

Shirly Kumala *, Kartika DwiYuliani and Partomuan Simanjuntak

Faculty of Pharmacy1, Magister Program of Pharmacy Faculty 2Pancasila University, Srengseng Sawah Jagakarsa, Jakarta, Indonesia

DOI: 10.13040/IJPSR.0975-8232.6(6).2349-53

2349-53

3951

877

10.

PHYTOCHEMICAL STUDIES AND IN VITRO ANTIOXIDANT POTENTIAL OF TWO DIFFERENT EXTRACTS OF CRINUM JAGUS

The antioxidant potential of the aqueous and hydro/ethanolic (ethanol/water) extracts of Crinum jagus were explored considering their total phenolic, flavonoid and proanthocyan contents, 1.1-Diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, ferrous ions chelating ability and nitric oxide radical inhibiting activity. Hydroethanolic extract has exhibited the highest total polyphenol...

C. Mvongo , P. Aimé Noubissi, R. Kamgang , C. Sara Minka Minka, A. Mfopa and Jean-Louis Essame Oyono

Laboratory of Endocrinology and Radio-Isotopes , Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon

DOI: 10.13040/IJPSR.0975-8232.6(6).2354-59

2354-59

2148

951

11.

AGGREGATES OF ALTERNATE AMPHIPHILC POLYANION TO CARRY ZWITTERIONIC DRUG IN AQUEOUS MEDIA

The effect of amphiphilic polyanion Poly(maleic acid-alt-octadecene)sodium salt on solubility of a zwitterionic drug (ampicillin trihydrate) in aqueous media was evaluated. This polymeric salt was obtained by an equimolar reaction of parent copolymer poly Poly(maleic acid-alt-octadecene)with an aqueous solution of NaOH. The obtained amphiphilic polyanion was purified by dialysis and lyophilization...

Constain Salamanca *, Andrés Quintero, Diego Pineda and Andrés Andrade

Natural Research Group, Faculty of Natural Sciences, Universidad ICESI-Colombia

DOI: 10.13040/IJPSR.0975-8232.6(6).2360-66

2360-66

1625

677

12.

STUDIES OF PRELIMINARY PHYTOCHEMICAL SCREENING, MEMBRANE STABILIZING ACTIVITY, THROMBOLYTIC ACTIVITY AND IN-VITRO ANTIOXIDANT ACTIVITY OF LEAF EXTRACT OF CITRUS HYSTRIX

In this present study, the leaf extracts of Citrus hystrix were subjected to a comparative evaluation of preliminary phytochemical screening, membrane stabilizing activity, thrombolytic activity and In-vitro antioxidant activity. The thrombolytic and membrane stabilizing activities were assessed by using human erythrocyte and the results were compared with standard streptokinase (SK) and standard ...

Mohammad Ali, Rumana Akhter, Syeda Najah Narjish, Mohammad Shahriar* and Mohiuddin Ahmed Bhuiyan

Phytochemistry Research Laboratory, Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(6).2367-74

2367-74

1528

815

13.

OPTIMIZATION OF INFLUENZA A AND B VIRUSES CULTIVATION CONDITIONS FOR PREPARATION OF TRIVALENT SEASONAL INFLUENZA SPLIT VACCINE

This article presents the results of studies on determination of optimal parameters of recombinant strains A/NYMC X-217 (H3N2) and B/NYMC BX-49 of influenza virus cultivation in chicken embryos. It is found that a maximum virus accumulation is formed under the following cultivation conditions: age of chicken embryos is 9-11 days in case of inoculation of the allantoic cavity, inoculated virus dose...

I. Akzhunusova *, N. Assanzhanova , K. Tabynov , B. Abdrakhmanova and A. Sansyzbay

The Research Institute for Biological Safety Problems , Zhambulskaya oblast, Kordaiskiy rayon, Gvardeisky, Republic of Kazakhstan

DOI: 10.13040/IJPSR.0975-8232.6(6).2375-81

2375-81

1538

443

14.

INCREASED INSULIN RESISTANCE, DYSLIPIDEMIA, PRO-INFLAMMATORY MARKERS AND ENDOTHELIAL DYSFUNCTION IN CASTRATED MALE RATS: ROLE OF TESTOSTERONE REPLACEMENT

Molecular effects of androgens on cardiovascular system are variable in nature and are concentration dependent. In spite of the evidences favoring possible involvement of reduced endogenous androgens in the pathogenesis of atherosclerotic vascular disease, there is no certain role of exogenous testosterone supplementation in normal or hypogonadal males to slow down the progression of atheroscleros...

M. M. Elseweidy*, N. N. Younis, R. S. Ameen and H. S. Essa

Biochemistry department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(6).2382-89

2382-89

1542

431

15.

ASSESSMENT OF PHARMACEUTICAL QUALITY CONTROL AND IN VITRO EQUIVALENCE OF VARIOUS BRANDS OF ATENOLOL (100MG) TABLETS AVAILABLE IN SUDANESE MARKET UNDER BIOWAIVER CONDITIONS.

As Atenolol is one of the first choice medications in the management of hypertension in Sudan, it was very important to carry out post authorization safety studies on some of the brands commercially available on the market. The pharmaceutical equivalence of three Atenolol 100 mg tablets was evaluated using official and non-official standards according to US Pharmacopoeia including weight variation...

Abdelrhman Abdelkarim *, Abdelkarim Mohammed and Mohammed Abdeen

Azal Pharmaceutical Co. LTD Khartoum, Sudan

DOI: 10.13040/IJPSR.0975-8232.6(6).2390-94

2390-94

2217

790

16.

PROTECTIVE ROLE OF TRIBULUS TERRESTRIS ON ALUMINIUM CHLORIDE – INDUCED REPRODUCTIVE TOXICITY IN THE MALE LABORATORY MOUSE

The present study deals with the efficacy of Tribulus terrestris (TT) on aluminium chloride (AlCl3) - induced alterations in the reproductive organs and fertility of the male laboratory mouse. Thirty adult male mice were divided into six groups of five each. Group I served as control while that of II, III and IV received various doses of AlCl3 (25, 50, 100 mg/kgBW/day, respectively), for 30 days. ...

Praveen Kumar and Poonam Singh*

Department of Zoology, MMV, Banaras Hindu University, Varanasi, U.P., India

DOI: 10.13040/IJPSR.0975-8232.6(6).2395-05

2395-05

1813

677

17.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEW BAYLIS-HILLMAN DERIVED NITRO METHYLENE IMIDAZOLE DERIVATIVES AS INSECTICIDAL AGENTS

A series of Baylis-Hillman derived N-cinnamyl substituted nitro methylene imidazole derivatives 4a-swere synthesizedfrom Baylis-Hillman acetates and nitro methylene imidazole compoundsand characterised by 1H NMR, IR, Mass and HRMS spectroscopy. Their insecticidal activities were evaluated against T. Castaneum and compared with a standard insecticide Permethrane. Preliminary biological activity tes...

R. Gampa , L. D. Chebrolu , K. Gudikandula , J. Rao Vaidya, V. Rao Ghanakota * and S. C. Maringanti

Tarnaka, Hyderabad- A.P., India

DOI: 10.13040/IJPSR.0975-8232.6(6).2406-17

2406-2417

1585

791

18.

VALIDATED HPTLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF EMTRICITABINE AND TENOFOVIR IN DRUG FORMULATION

A simple, precise, specific and accurate high-performance thin-layer chromatographic method has been developed for the simultaneous determination of Emtricitabine (EMB) and Tenofovir (TEN) in pharmaceutical dosage form. The separation was carried out on Merck HPTLC aluminum plates of silica gel 60 F254, (20×10 cm) with 250 μm thickness using toluene: ethylacetate: methanol in the ratio (2:8:1 v/...

P.G. Sunitha and K. Ilango *

Department of Pharmaceutical Chemistry , SRM College of Pharmacy, SRM University, Kattankulathur, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2418-22

2418-22

1598

540

19.

PROTECTIVE EFFICACY OF ETHYL 3, 4- DIHYDROXY BENZOATE AGAINST EXERCISE INDUCED DAMAGES: PUTATIVE ROLE IN IMPROVING PHYSICAL PERFORMANCE

Training under hypoxic conditions is known to enhance physical performance. The possible mechanism might be the stabilization of Hypoxia Inducible Factor (HIF), which otherwise is degraded under normoxia by the action of Prolyl Hydroxylase domain enzymes (PHD). Stabilization of HIF leads to upregulation of its target genes leading to improved erythropoiesis, angiogenesis and antioxidant status as ...

C. Nimker, D. P. Singh, G. Kaur, S. Saxena and A. Bansal*

Experimental Biology Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi-110054, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2423-36

2423-36

1708

464

20.

EVALUATION OF ANTI- ANGIOGENESIS ACTIVITY OF NEEM ROOT USING ZEBRA FISH MODEL

Introduction: Angiogenesis is the formation of new blood vessels which is a process involved in development of tumors and other neovascular diseases. Developmental angiogenesis in zebra fish embryos is a relevant and emergent model to evaluate the anti-angiogenesis activity which was used in present study. With this model, blood vessel formation and the blood flow can be clearly observed. Various ...

L. P. B. Lavanya Uppuluri*, V. N. Garge, and V. J. Kadam

Department of Pharmacology, Bharati Vidyapeeth College of pharmacy, University of Mumbai, Navi Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2437-40

2437-40

1847

801

21.

A NOVEL TETRAVALENT RECOMBINANT ENVELOPE DOMAIN III VACCINE AGAINST DENGUE: AN IN SILICO APPROACH

The global rise in dengue cases is a major public health concern in terms of morbidity and mortality. The recent study reports 390 million dengue infections annually of which 96 million infections becomes clinically or subclinically severe. Therefore, development of an effective tetravalent vaccine against dengue is a top priority. Dengue envelope domain III is a surface exposed protein; involved ...

A. Kulkarni *, P. Shinde, S. Kothari, R. Warke, A. Chowdhary and R. A. Deshmukh

Department of Virology , Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2441-50

2441-2450

1622

537

22.

ASSESSMENT OF TRADITIONAL HOME REMEDY USAGE AMONG PEOPLE IN HARAR, ETHIOPIA

Many countries in Africa, Asia and Latin America use traditional medicine (TM) to meet some of their primary health care needs. In Ethiopia, Traditional Medicine (TM) is a part of the national heritage. Also Ethiopia is the home of many nationalities and remarkably diverse flora, including numerous endemic species that are utilized in the different traditional medical practices. Beyond the conveni...

Temesgen berhane and G. Vijaibasker *

Haramaya University, School of Pharmacy, College of Health & Medical Sciences, Ethiopia

DOI: 10.13040/IJPSR.0975-8232.6(6).2451-61

2451-2461

15184

697

23.

STUDY OF ANTIDEPRESSANT ACTIVITY OF CHRONIC ADMINISTRATION OF TRAMADOL AND WHEN IT IS CO-ADMINISTERED WITH FLUOXETINE IN LOW DOSES IN SWISS ALBINO MICE USING DESPAIR SWIM TEST

Objective: To evaluate the antidepressant activity of chronic administration of Tramadol alone and when combined with Fluoxetine in low doses in albino mice. Methods: The antidepressant effect was determined by recording the immobility time in Despair Swim Test. The mice were randomized into seven groups, with six mice in each group. Group 1 mice were given normal saline (10 ml/kg) which served as...

G. Sirisha *, N. S. Usha and B. Santhamma

Department of Pharmacology, Kamineni Institute of Medical Sciences, Narketpally Hyderabad, Telangana- 500007, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2462-67

2462-67

1452

522

24.

ENHANCING THE ABSORPTION OF CURCUMINOIDS FROM FORMULATED TURMERIC EXTRACTS

The Turmeric (Curcuma Longa.L) plant, a perennial herb belonging to the ginger family is cultivated extensively in South East Asian countries. The polyphenols Curcumin, De methoxy curcumin and Bisdemethoxy curcumin collectively known as curcuminoids ,which aid in the treatment of degenerative diseases like cancer, alzheimer’s, cardio vascular diseases, arthritis, diabetes and immune deficiencies...

K .N. Pushpakumari, Naijo Varghese * and Kavitha Kottol

Research and Development Department, AVT Natural Products Limited, Vazhakulam, Aluva-683107, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.6(6).2468-76

2468-76

2726

794

25.

EVALUATION OF ANTI-MICROBIAL ACTIVITY OF IN VITRO AND IN VIVO PLANT PARTS OF MERREMIA DISSECTA AND MERREMIA AEGYPTIA

The present study deals with the evaluation of the antimicrobial activity in methanolic extracts of in vivo (leaf, stem and seed) and in vitro (callus) plant parts of Merremia dissecta and Merremia aegyptia belonging to family Convolvulaceae. The antimicrobial activity against six different microbial strains, four bacterial viz. Bacillus thuringiensis, Bacillus subtilis, Eschrechia coli and Pseudo...

Ridhi Joshi*, Shikha Agarwal and Vidya Patni

Plant Pathology, Tissue Culture and Biochemistry Laboratory, Department of Botany, University of Rajasthan, Jaipur-302004, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2477-83

2477-83

2807

1215

26.

SIMULTANEOUS EQUATION METHOD AND ABSORPTION CORRECTION METHOD FOR THE ESTIMATION OF PERINDOPRIL ERBUMINE AND AMLODIPINE BESYLATE IN BULK AND IN COMBINED TABLET DOSAGE FORM USING UV SPECTOPHOTOMETRY

In the present work a simple, accurate and precise method has been developed and validated for the simultaneous estimation of Perindopril Erbumine (PDE), Amlodipine Besylate (AMD)and in their combined dosage form by UV Spectrophotometric Methods. The Method A employs estimation of drugs by simultaneous equation method (SEM) using 298.3 nm and 231.9nm i.e. λmax values of PDE and AMD respectively. ...

S. K. Masthannamma*, I. S. Tejaswini, P. Saidulu and G. Rambabu

Department of Pharmaceutical Analysis, University College of Pharmaceutical Science, Acharya Nagarjuna University, Nagarjunanagar, Guntur - 522510 Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2484-90

2484-2490

2041

639

27.

EVALUATION OF ANTIOXIDANT AND ANTI-ULCER ACTIVITY OF SMILAX PERFOLIATA LINN.

The leaves and fruits of Smilax perfoliata are traditionally used for treatment of various ailments such as rheumatism, lumbago, nourishing the functions of spleen, stomach, muscle and bone. The intent of the present study was to evaluate the antioxidant and anti-ulcer activity of ethanolic leaves and fruits extract of Smilax perfoliata Linn in albino rats. Gastric ulcers were induced by employing...

S. Abdul Arsalan *, S. B. Mahmood, S. Rashid Ali, A. Begum, Md. Ismail, Md. Akbar Siddiq

Sultan ul Uloom college of Pharmacy, Mount Pleasant, Hyderabad, Adhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2491-95

2491-95

1555

577

28.

PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY OF GYMNEMA SYLVESTRE R.BR. EX SCHULT.

The present investigation deals with preliminary phytochemical analysis and in vitro antibacterial potentials of different solvent extracts of Gymnema sylvestre were demonstrated. The phytochemical tests of the extracts have revealed the presence of alkaloids, flavonoids, phenols, tannins, terpenoids carbohydrate, tannin, and saponin. Five gram-positive (Bacillus cereus, Bacillus subtilis, Strepto...

Mariappan Senthilkumar

Post Graduate and Research Department of Botany, Government Arts College, Dharmapuri - 636705, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.6(6).2496-03

2496-2503

2195

590

29.

ANTI-MICROBIAL AND ANTI ADHESIVE PROPERTIES OF LACTOBACILLUS AND BACILLUS SP.

The aim of this study was to determine the anti-microbial and anti-adhesive properties of a Lactobacillus and Bacillus, against several micro-organisms, including Gram-positive and Gram-negative bacteria. Biofilm producing micro- organisms were isolated from different samples. The isolated micro-organism were characterized and identified. The anti-microbial and anti-adhesive activities were determ...

Anayata Sharma*, Jitesh Sony, Sanjeevkumar Arora and Sakshi

Department of Biotechnology, D.A.V College, Abohar. Punjab, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2504-10

2504-10

1449

548

30.

COMBINED EFFECTS OF ATORVASTATIN AND NICOTINE ON TESTICULAR EXPRESSION OF STEROIDOGENIC ENZYMES IN EXPERIMENTAL RATS

Nicotine and atorvastatin have indirect effects on reproductive function. So this study focused on changes in testosterone biosynthesis in rats co administered nicotine and atorvastatin. Rats were divided into 4 groups.(1) Control, (2) Atorvastatin (10 mg/Kg b.wt), (3) Nicotine (0.6 mg/Kg b.wt)and (4) Atorvastatin (10 mg/Kg b.wt) + nicotine (0.6 mg/Kg b.wt). After sixty days of treatment  testicu...

Syam Das S and M Indira*

Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram-695 581, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.6(6).2511-17

2511-17

1627

483

31.

SUN PROTECTIVE ACTIVITY OF WATER IMMISCIBLE PIGMENTS OF FRUIT EXTRACT OF GARCINIA INDICA

In order to protect from UV radiations, naturally occurring safe and broad spectrum components are desired. The chemical sun blockers viz. ZnO and TiO2 gives broad spectrum UV protection but, its safety is doubted. Aim of present communication was to study UV protective activity of water immiscible pigments of fruit rinds of Garcinia indica. Out of various extracts used for sun protective activity...

M. S. Dike and M. A. Deodhar *

Department of Botany, KET’s V.G. Vaze College of Arts, Science and Commerce, Mithagar Road, Mulund (E), Mumbai 400081, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2518-24

2518-24

1514

583

32.

PHYTOCHEMICAL STUDIES ON PIPER CHABA HUNTER

The plant Piper chaba is an herbaceous and flowering plants. It is a tropical family of five genera and 500 species which are distributed in tropical and subtropical regions. All the parts of this plant such as Stem, leaves and fruits has activated medicinal compounds. Stem and leaves were successively extracted with different organic purified solvent such as petroleum ether, chloroform, ethyl ace...

Md. Saiful Islam*, A. Chandra Roy , Md. Moinul Haque , Md. S. Hossain and M. Abu Sayeed

Department of Applied Chemistry & Chemical Engineering , Rajshahi University, Rajshahi, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(6).2525-31

2525-31

2570

592

33.

EXTRACTION AND CHARACTERIZATION OF ASTAXANTHIN FROM THE CRUSTACEAN SHELL WASTE FROM SHRIMP PROCESSING INDUSTRIES

India having a large stretch of marine coastline is advantageous as a natural resource for marine aquaculture. But the waste produce from the marine processing industries fetch a greater environmental risk as there is accumulation of wastes in huge quantity. These wastes are a larger source of natural carotenoids that have a huge pharmaceutical potentials. So proper initiatives must be taken to re...

Jikasmita Dalei* and Debasish Sahoo

Department of Biochemistry and Microbiology (R&D Division), Nitza Biologicals (P) Ltd., Secunderabad, Telengana, India.

DOI: 10.13040/IJPSR.0975-8232.6(6).2532-37

2532-37

5553

1493

34.

A FACILE SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME MACROCYCLIC COPPER COMPLEXES

Biologically potent compounds are one of the most important classes of materials for the upcoming generations. Increasing number of microbial infectious diseases and resistant pathogens create a demand and urgency to develop novel, potent, safe and improved variety of antimicrobial agents. This initiates a task for current chemistry to synthesize compounds that show promising activity as therapeut...

Neha Mathur * and Sonlata Bargotya

Department of Chemistry, Govt. P.G. College, Dausa - 303303, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2538-45

2538-2545

1473

1081

35.

GC-MS ANALYSIS OF BIOACTIVE CONSTITUENTS OF GLOCHIDION ELLIPTICUM WT.

The aim of the present study is to identify the volatile, bioactive phytoconstituents present in the ethanolic extract of the leaves of Glochidion ellipticum Wt. (Euphorbiaceae) was carried out by using GC-MS analysis, while mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology and Wiley library. Twenty seven components from leaves o...

Indhiramuthu Jayashree*, D. H. Geetha and M. Rajeswari

PG and Research Department of Botany, Vellalar College for Women, Erode-12, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2546-50

2546-2550

2039

1314

36.

SYNERGISTIC ANTIOXIDANT ACTIVITY OF LIPOIC, FERULIC AND ELLAGIC ACID

Antioxidants prevent the damage done to the cells by free radicals that are released during the normal metabolic process of oxidation. Some of these free radicals include reactive oxygen species, hydroxyl, the superoxide anion, hydrogen peroxide and peroxyl which generate metabolic products that attack lipids in the cell membranes or DNA. These are associated with DNA damage, carcinogenesis and ce...

P. Chawla, H. Gaur , M. Tripathi , M. Tripathi , B. Agarwal and A. Pandey *

Department of Chemistry , CMP Degree College (Constituent College of University of Allahabad), Allahabad, U.P. India

DOI: 10.13040/IJPSR.0975-8232.6(6).2551-56

2551-2556

1642

700

37.

A STUDY ON ATTITUDE AND SATISFACTION OF PATIENTS TOWARDS UNANI AND AYURVEDIC HEALTH CARE SERVICE WITHIN MEDICAL PLURALISM IN THE CONTEXT OF BANGLADESH

Unani and Ayurvedic heath care system is considerable areas of medical treatment in Bangladesh where patient can avail it from different Govt. or private hospital. This cross-sectional study was undertaken to find out the satisfaction of patients attending in this health care system from January to April 2014. A total of 240 respondents were interviewed with an interviewer administered semi-struct...

Md. M. Nabi, Md. Abu Taher, H. Sheikh *, Md. S. R. Dulal, Md. K. Alam, Md. Manirul Islam

Faculty of Unani and Ayurvedic Medicine, Hamdard University, Sonargaon, Narayanganj, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(6).2557-68

2557-68

1989

595

38.

PHARMACOKINETICS AND PHARMACODYNAMICS OF ELORES IN COMPLICATED URINARY TRACT INFECTIONS CAUSED BY EXTENDED SPECTRUM BETA-LACTAMASE STRAINS.

The pharmacokinetic/pharmacodynamic indices generally predict the efficacy of antibiotics when used alone. The information related to these indices for the combination products and that too in cases of resistant bacterial infections is limited. The present study involved treatment of 12 subjects with severe complicated urinary tract infections caused by resistant extended spectrum beta lactamase b...

V. S. Suresh Attili * and Manu Chaudhary

Bibi General Hospital and Cancer Centre , Malakpet, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2569-78

2569-78

3086

1550

39.

A SIMPLE VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF ARMODAFINIL IN BULK AND PHARMACEUTICAL DOSAGE FORM

Armodafinil is an enantiopure of the wakefulness -promoting drug Modafinil, unique psycho stimulant recently approved by the US Food and Drug Administration for the treatment of narcolepsy; it is useful for treating excessive day time sleepiness. A simple, sensitive and accurate and economical spectrophotometric method has been developed for the estimation of Armodafinil in bulk and pharmaceutical...

Tejaswi Jonnalagadda* and Shantakumari Katakam

Department of Pharmaceutical analysis, Nirmala College of Pharmacy, Nagarjuna University, Mangalagiri, Guntur, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2579-81

2579-81

1698

554

41.

FORMULATION DESIGN AND IN VITRO CHARACTERIZATION OF FELODIPINE NANO-SUSPENSION

Felodipine is a member of the dihydropyridine class of calcium channel antagonists (calcium channel blockers) and is insoluble in water. To counter act above side effects, to enhance bioavailability of felodipine in blood stream and to make drug to more targeting, felodipine drug is being designed as nanosuspension formulation using hydroxyl propyl methyl cellulose and hydroxyl propyl cellulose as...

Suryakanta Nayak *, Dibyasundar Panda and Ajaya Kumar Patnaik

Department of Pharmaceutics , L.B. Rao Institute of Pharmaceutical Education and Research, Khambhat, Anand, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2587-93

2587-93

2114

686

42.

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL SCREENING OF Cu (II) COMPLEXES OF PINCER LIGANDS

The ligands bis-(benzimidazolyl)pyridine (BBIP) and bis-(benzimidazolyl)benzene (BBIB) have been used to synthesize Copper(II) complexes [Cu(BBIP)2]Cl2 and [Cu(BBIB)2]Cl2 respectively. The complexes are characterized by analytical and spectral (FTIR, 1H NMR and electronic) techniques. IR spectra of complexes show that the tertiary nitrogens in the ligand are involved in the co-ordination to the me...

Ramya Ayyasamy *, Parameswari Kandasamy and Subramanian Chitra

Department of Chemistry, PSGR Krishnammal College for women, Peelamedu, Coimbatore - 641004, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.6(6).2594-00

2594-00

1312

530

43.

DEVELOPMENT OF AMRABEJAADI ANTIDANDRUFF CREAM – AN AYURVEDIC FORMULATION

During the recent times, the whole world is conscious about the health hazards and toxicity associated with indiscriminate use of synthetic drugs. There is extensive surge of drugs which are safer and having fewer side effects. So there is a growing interest in natural remedies for the management of different ailments. Ayurveda describes different remedies prepared by using maximum percentage of t...

Baby Ganeriwala *, R. R. Hiremath , U. B. Bolmal and K. S. Gudaganatti

Ragunath Ayurved Mahavidyalaya and Hospital , Contai, Purva Mednipur, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2601-45

2601-09

1707

885

44.

HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY OF METHANOLIC BARK EXTRACT FROM ALBIZIA LEBBECK LINN.

In the present study, high performance thin layer chromatographic method was developed and quantification of Diosgenin from Albizia lebbeck. TLC auminium precoated with silica gel were used as the stationary phase in a twin see through glass chamber saturated with n-butanol: glacial acetic acid: water (4:1:1) mobile phase, performed at room temperature (25ºC ± 2). The Rf value of diosgenin was f...

Ariharasivakumar Ganesan * and Kavimani Subramanian

KMCH College of Pharmacy , Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2610-15

2610-15

1730

639

45.

CHEMICO-BIOLOGICAL EFFECTS OF MONASCUS FERMENTED RICE (ANGKAK) IN HYPERLIPIDEMIC RATS: A COMPARATIVE ANALYSIS

Angkak rice (red mold rice, red yeast rice, Chinese red rice) which is a product of solid fermentation was prepared from non glutinous rice (Oryza sativa L.). Five different angkak samples containing varied level of lovastatin, pravastatin and citrinin suspension at a dose of 1g/kg were administered to hyperlipidemic rats for 30 days. There was a significant decrease in serum total cholesterol (30...

Mojeer Hasan, Prakash Chandra Bhatt and Bibhu Prasad Panda*

Microbial and Pharmaceutical Biotechnology Laboratory, Centre for Advanced Research in Pharmaceutical Science, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2616-25

2616-25

1777

568

46.

DETERMINATION OF LAFUTIDINE THROUGH OXIDATIVE COUPLING REACTION IN BULK SAMPLE AND DOSAGE FORMS- A NEW APPROACH

A simple, sensitive, highly accurate method has been developed for the determination of Lafutidine in bulk sample and dosage forms. This method is based on the oxidative coupling reaction of drug with 3-methyl-2-benzothialinone hydrazine hydrochloride (MBTH) reagent in the presence of ferric chloride to form green colored chromogen exhibiting maximum absorption at 630 nm. Beer’s law was obeyed a...

M. Srinivasa Reddy and B. Hari Babu *

Department of Chemistry, Acharya Nagarjuna University, Guntur, A.P., India

DOI: 10.13040/IJPSR.0975-8232.6(6).2626-30

2626-30

1669

786

47.

WOUND HEALING ACTIVITIES OF FICUS RACEMOSA LEAVES ETHANOLIC EXTRACT ON EXCISION WOUND MODEL OF WISTAR ALBINO RATS

Present study describes wound healing activities of Ficus racemosa (Linn.) leaves extract on excision wound model of wistar albino rats. During the study, fresh plant materials after shade drying was used for the isolation of extract using soxhlet apparatus and percentage yield was obtained (3.50% in ethanol). Then, preliminary phytochemical screening of the extract was done and certain secondary ...

Rajesh Bakoriya , Tessy Thomas and Kapil K. Soni*

Department of Bioscience, Barkatullah University, Bhopal, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2631-35

2631-35

1829

905

48.

ELICITATION, BIOCONVERSION AND QUANTIFICATION OF BERBERINE FROM CISSAMPELOS PARIERA CALLUS CULTURES

Cissampelos pariera, an important medicinal plant was subjected to elicitation and bioconversion of precursors for the formation of Berberine, an important medicinal component. In vitro cultures of Cissampelos pariera, was successfully established using stem and leaf explants. MS Media fortified with IAA (2 mg/l) alone and MS media enriched with IAA (2mg/l) showed profuse callusing from leaf and s...

Vikash Shad and M. A. Deepa *

Kristu Jayanti College, K Narayanapura, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2636-40

2636-40

1502

798

49.

SCREENING OF SOLVENT EXTRACTS OF VALERIANA JATAMANSI FOR ISOLATION OF ANTIMICROBIAL COMPOUND

In the present study, the hydro-alcoholic and hexane extracts of the plant, Valeriana jatamansi (Family: Valerianaceae) were screened for antimicrobial activity against pathogenic and drug resistant strains.  The non polar extracts did not showed any activity against any of the pathogenic strains. Amongst these extracts the hydro-alcoholic extracts of the plant, Valeriana jatamansi, showed potent...

Pradeep Babu*, Satish K. Verma and Abhishek Mathur

Uttarakhand Technical University (UTU) , Dehradun (U.K), India

DOI: 10.13040/IJPSR.0975-8232.6(6).2641-48

2641-2648

2102

637

50.

IN VITRO ANTI-ARTHRITIC ACTIVITY OF ELAEOCARPUS SERRATUS LINN. (ELAEOCARPACEAE)

In the present study the anti-arthritic activity of ethanolic extracts of leaf and seed of Elaeocarpus serratus L. was evaluated in vitro using two models namely on the inhibition of protein denaturation and anti-proteinase activities. Indomethacin was used as a standard drug. Results revealed that the ethanolic leaf and seed extracts of E. serratus at two different concentrations (200 and 400 µg...

D. H. Geetha*, Indhiramuthu Jayashree and M. Rajeswari

PG and Research Department of Botany, Vellalar College for Women, (Autonomous), Erode, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(6).2649-51

2649-51

1979

852