Volume 5 (2014) - Issue 11, November
Review Articles
OXAZOLINES: THEIR SYNTHESIS AND BIOLOGICAL ACTIVITY
Heterocylic chemistry have been known for many years but in recent years heteocyclics received great attention. In heterocyclic chemistry oxazoline is one of the most important moiety. Oxazoline moiety shows a wide range of application such as in agriculture industry, pharmaceutical, food industry, natural product, medicine, polymers and various other industries. Oxazoline moiety constitutes the c...
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A REVIEW ON BIOCHEMICAL AND THERAPEUTIC ASPECTS OF GLUTAMINASE
One of the prime candidates in the treatment of debilitating human cancers includes a family of enzymes referred to as L- glutaminases. The antitumor activity of these enzymes found effective in countering Acute Lymphoblastic Leukemia (ALL a commonly diagnosed pediatric cancer.). Further it is found to inhibit four human tumour cell lines namely Hep-G2 [Human hepatocellular carcinoma cell line], M...
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SIGNIFICANCE OF PHARMACEUTICAL FACTORS ON SELECTION OF BIOBATCH
Biobatch is usually prepared for the purpose of pharmacokinetic evaluation before NDA or IND filing. There are several critical issues that one has to face during the audit process like equivalence between the Biobatch and proposed commercial production batch. During the development and scale-up of the manufacturing process, various standard operating processes have to be documented to provide lin...
12339
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STEREOCHEMISTRY AND ITS ROLE IN DRUG DESIGN
When designing small molecules to interact with the targets, one should consider stereo selectivity. As considerations for exploring structure space evolve, chirality is increasingly important. Binding affinity for a chiral drug can differ for diastereomers and between enantiomers. For the virtual screening and computational design stage of drug development, this problem can be compounded by incom...
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Research Articles
PREPARATION AND DRUG RELEASE BEHAVIORS OF pH-SENSITIVE MICROCAPSULES
The pH-sensitive microcapsules were prepared by interfacial polymerization, in which caffeine was used as a model drug and hyperbranched poly L-lysine (HBPL) and terephthaloyl chloride as wall-forming materials. The microcapsules were characterized by Malvern particle size analysis, scanning electron microscopy, Fourier transforms infrared spectrophotometry (FTIR) and UV-vis spectrophotometer. Tri...
3689
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QUALITY BY DESIGN IN THE DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD BY ULTRAVIOLET-VISIBLE SPECTROPHOTOMETRY FOR QUANTIFICATION OF HYDROXYCHLOROQUINE SULFATE
Developed originally as an antimalarial agent, the hydroxychloroquine sulfate (HCQ) is often used as a slow-acting anti-rheumatic drug in treating disorders of connective tissue. The methods of quantification of HCQ sulfate, despite the undeniable advantages, have certain limitations, such as high cost of operation and maintenance of equipment, sample processing and analysis of the results relativ...
5798
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IN-VITRO AND IN-VIVO EVALUATION OF NIOSOMES CONTAINING CELECOXIB
Niosomes as a vesicular system are well documented for delivering drugs, in a controlled manner to enhance bioavailability and get better therapeutic effect over a longer period of time. Celecoxib is an NSAID, selective COX-2 inhibitor, which is used for treatment of rheumatoid arthritis, osteoarthritis, and acute pain. The present study dealt with the preparation and characterization of celecoxib...
3917
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IN VITRO COMPARATIVE COAGULATION STUDIES OF NOVEL BIODEGRADABLE N, O-CARBOXYMETHYLCHITOSAN (NO-CMC) AND OLIGO-CHITOSAN (O-C)
Naturally obtained chitosan biopolymers are increasingly being formulated as bioadhesives due to their hemostatic properties. Comparative studies have been conducted to measure the hemostatic capacity of biodegradable 7% N,O-carboxymetylchitosan (NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, oligo-chitosan (O-C) and oligo-chitosan 53 (O-C 53). Biodegradability (loss of mass) of these chitosans in ph...
3531
1236
FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS BY USING NATURAL POLYMER
The study was aimed at developing mucoadhesive buccal tablet containing Carvedilol. The effect of two independent variables, Casein (X1) and hydroxypropylmethyl cellulose (HPMC K4M) (X2) at three different levels (-1, 0, +1) on dependent variable including hardness (Y1), cumulative percentage drug release at 6 h (Y2) and 12 h (Y3) using 32 full factorial design. FTIR and DSC results showed no ...
8520
2025
ZYGOPHYLLUM GAETULUM AQUEOUS EXTRACT PROTECTS AGAINST DIABETIC DYSLIPIDEMIA AND ATTENUATES LIVER AND KIDNEY OXIDATIVE DAMAGE IN STREPTOZOTOCIN INDUCED-DIABETIC RATS
Zygophyllum gaetulum is one of several traditional remedies used for diabetes treatment in Algeria. The purpose of this study is to investigate the effects of this plant on hyperglycemia, insulin sensitivity indexes, lipid profiles, lecithin: cholesterol acyltransferase (LCAT) and paraoxonase (PON1) activities and liver and kidney antioxidant status, in streptozotocin-induced diabetic rat. Diabete...
3248
1217
SYNTHESIS AND SPECTROSCOPIC STUDIES OF COBALT (II) COMPLEXES WITH NITROGEN- OXYGEN AND NITROGEN SULPHUR DONOR LIGANDS
CoII complexes of ligands pyridine3carboxamide thiosemicarbazone (L1), pyridine 3 carboxamide semicarbazone (L2), pyridine2carboxamide thiosemicarbazone (L3) and pyridine 2 carboxamide semicarbazone (L4) have been synthesized. The ligands were characterized based on elemental analyses, IR, 1HNMR studies while the complexes were characterized by elemental analyses, molar conductance, magnetic momen...
3111
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EFFECT OF ELYTRARIA ACAULIS EXTRACTS ON FERTILITY IN MALE ALBINO RATS
Surgeries like vasectomy, tubectomy, and medication (contraception) for the population control are not fully restraining the population growth. Medicine available to control birth rate carrying side effects. The attempt of exploring the importance of Ayurveda the present work was carried out. The methanol extract of the plant Elytraria acualis was prepared by maceration technique. Extract affect...
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DEVELOPMENT AND CHARACTERIZATION OF ORAL DISSOLVING FILM FOR PROMETHAZINE HCL
Promethazine hydrochloride, one of the most effective agents for treating motion sickness, mainly acts as a strong antagonist of H1 receptor (antihistamine) and it blocks the action of acetylcholine on the receptors (anticholinergic effect). The purpose of present work was a development of fast dissolving oral film of promethazine HCl to overcome the limitation of current routes of administration,...
4682
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ASSESSMENT AND EVALUATION OF HEXACHLOROCYCLOHEXANE (HCH) AND DICHLORODIPHENYLTRICHLOROETHANE (DDT) RESIDUES AND EXTENT OF DNA DAMAGE IN CATTLE OF KASARGOD DISTRICT, NORTHERN KERALA, INDIA
Pesticide uses pose a serious threat to environment and public health owing to their persistence and tendency to accumulate in animal and plant tissues. The present investigation was conducted to analyze pesticide residues mainly HCH and DDT in field, and biological samples from the plantation areas of Northern Kerala, India and the extent of DNA damage in cattle was measured. Environmental sample...
3104
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HEPATOPROTECTIVE POTENTIAL OF YOUNG LEAVES OF TRITICUM AESTIVUM LINN. AGAINST CCl4 INDUCED HEPATOTOXICITY
The plant selected for the activity is obtained from the ninth day young leaves of Triticum aestivum Linn. belonging to the family Poaceae. The plant is commonly known as Wheatgrass which is used for various medicinal and health benefits for many years. It is considered as a cleansing and purifying agent from ancient times and yet can be used for its healing properties because of its nutritional v...
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ANTIMICROBIAL POTENTIAL OF ACACIA NILOTICA EXTRACTS ON FEW DENTAL PATHOGENS
The acute dental abscess is frequently underestimated in terms of its morbidity and mortality. The risk of potentially serious consequences arising from the spread of a dental abscess is still relevant today with many hospital admissions for dental sepsis. Acacia nilotica was commonly known in India as Babul has a wide range of medicinal uses. In the present study antibacterial activity of differe...
2006
562
OPTIMIZATION STUDIES FOR ENHANCED BIOACTIVE METABOLITE PRODUCTION BY STREPTOMYCES VIOLACEORUBER VLK-4 ISOLATED FROM THE SOUTH COAST OF ANDHRA PRADESH, INDIA
The aim of the present study was to design the suitable culture medium and also optimize the culture conditions for enhanced production of antimicrobial metabolites by Streptomyces violaceoruber VLK-4 which exhibited a broad spectrum of activity against bacteria and fungi. Production of bioactive metabolites by the strain was high in modified yeast extract-malt extract dextrose (ISP-2) broth as co...
3222
1144
RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF CEFPODOXIME PROXETIL
A new simple and rapid reverse-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous estimation of cefpodoxime proxetil in bulk drugs and pharmaceutical dosage form. The separation was accomplished on a sunfire C-18 (250 × 4.6 mm, 5 μm) column with a mobile phase consisting of Methanol; Water (70:30 v/v) at a flow rate of 0.8 mL/min. The...
2409
0
ETODOLAC DISSOLUTION IMPROVEMENT BY PREPARATION OF SOLID DISPERSIONS WITH CYCLODEXTRIN COMPLEX’S
Etodolac is an anti-inflammatory drug that is poorly soluble in water. This paper describes an approach to improve the dissolution rate of Etodolac by using solid dispersions (SDs) in hydrophilic polymers. The solid dispersions prepared with a Co-evaporation, kneaded method & Physical Mixture method using different concentrations of α-cyclodextrin (α-CD). The release of Etodolac from various...
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VOLTAMMETRIC DETERMINATION OF RUPATADINE AT GRAPHENE MODIFIED GLASSY CARBON ELECTRODE
Electrochemical behavior of rupatadine, an anti-allergic drug was studied at graphene modified glassy carbon electrode in Britton-Robinson buffer (pH 6.5) by square wave voltammetry (frequency, 50 Hz; amplitude, 0.02 V; step potential, 0.005 V) and cyclic voltammetry (scan rates, 20-100 mV/s) techniques. Cyclic voltammetry revealed the oxidation of rupatadine corresponding to N-dealkylation which ...
3485
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ACUTE AND 28-DAY REPEATED DOSE TOXICITY OF AVERRHOA CARAMBOLA LEAVES ETHANOLIC EXTRACT IN RODENTS
Averrhoa carambola -L. (Oxalidaceae) has great importance in the Indian traditional system of medicine for controlling diabetes and piles: the combined extracts of leaves as well as fruits of A. carambola are used for the treatment of jaundice, gastric problems and other chronic conditions as well as in food supplements.The objective underlying this experiment is to determine the safety profile of...
3390
1035
A NOVEL SPECTROFLUORIMETRIC METHOD FOR THE DETERMINATION OF MEMANTINE HYDROCLORIDE IN BULK AND PHARMACEUTICAL FORMULATION
The author selected and developed a new simple, sensitive and reproducible spectrofluorimetric method and validated for the determination of Memantine Hydrochloride in bulk as well as pharmaceutical formulations depending on condensation of Memantine hydrochloride with 1, 2 - Naphthoquinone -4- sulphonate (NQS) in an alkaline medium to become a product with orange color. The spectrofluorimetri...
3755
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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF CINNARIZINE AND DIMENHYDRINATE IN TABLET DOSAGE FORM
A simple, rapid and precise reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of Cinnarizine and Dimenhydrinate in Tablet Dosage Form. Chromatography was performed on a PhenomenexPartisil ODS C18 (250 X 4.6 mm) 5mm column using Acetonitrile: Water (90:10) as a mobile phase. The detection of the synthetic mixture was carried out at 265 nm wi...
5780
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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MIGLITOL AND METFORMIN HYDROCHLORIDE IN TABLET DOSAGE FORM.
A simple, rapid and precise stability indicating reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of Miglitol and Metformine Hydrochloride in their tablet dosage form. Chromatography was performed on a Phenomenex ODS C18 (250 X 4.6 mm) 5mm column using Water: Methanol (50:50, v/v) pH: 4 mixture as a mobile phase. The detection was carried ...
6775
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ANTIMYCOBACTERIAL ACTIVITY OF FOLIOSE LICHENS ON PLANT AND ANIMAL PATHOGENS
Antimicrobial effects of different extracts of lichens were evaluated in this study. Acetone extract of Heterodermia boryi have shown maximum inhibitory activity against Escherichia coli (22mm) followed by Staphylococcus aureus (21mm)and Pseudomonas fluorescenes (20 mm). Among fungi, diethyl ether extract gave desirable sensitivity pattern against Pestalotia foedans was very sensitive (21mm) follo...
3302
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ISOLATION OF ACTIVE COMPOUNDS FROM HYDRO ALCOHOLIC EXTRACT OF CARDIOSPERMUM HALICACABUM LINN
The uses of plant medicines are very common in Asia and developing countries. Phytochemicals has been used to treat chronic as well as infectious diseases. Cardiospermum halicacabum Linn. (Sapindaceae) is an herbaceous climber, commonly found throughout India, used as vegetable as well as traditional medicine for rheumatism, lumbago and nervous diseases. Many pharmacological studies have been done...
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SENSITIVE AND SELECTIVE METHODS FOR DETERMINATION OF PROTEOLYTIC ACTIVITY OF FORMULATION CONTAINING BROMELAIN AND TRYPSIN AS PROTEOLYTIC ENZYMES
Accurate and sensitive assay methods for quantitative determination of Rutoside trihydrate (rutin), Trypsin and Bromelain in tablet formulation based on UV-spectrophometric analysis were developed and validated. This three drug combination has anti-inflammatory properties and hence is used for treatment of edema and inflammations. Rutin was analyzed directly by UV-Vis spectrophotometer at 257nm be...
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ANTIOXIDANT ACTIVITY OF GOAT LIVER SLICES TREATED WITH CUCUMIS MELO (L). FRUIT EXTRACT
Plant derived natural products such as flavonoids, terpenes, alkaloids and polysaccharides have received considerable attention in recent years due to diverse pharmacological properties including cytotoxic and cancer chemo preventive effects. From a long period of time medicinal plants or their secondary metabolites have been directly or indirectly playing an important role in the human society ...
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EVALUATION OF ANTI – CANCER ACTIVITY OF BARK OF CRATAEVA NURVALA BUCH. HAM AGAINST THREE CELL LINES
The present study was aimed to evaluate in-vitro anti-cancer activity of ethanolic extract of Crataeva nurvala Buch. Ham. The method used for determining the anticancer activity was the MTT bio-assay using A549(Human Lung Carcinoma) cell line, Hela (Human Cervix)cell line and MDA-MB(Human Adenocarcinoma, Mammary Gland)cell line. The ethanolic extract of Crataeva nurvala bark at different concentra...
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A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN AND PRASUGREL IN TABLET DOSAGE FORM
Aim of the present work is to develop a rapid, simple, precise, accurate and reproducible reverse phase high performance liquid chromatographic method for simultaneous determination of Aspirin and Prasugrel in tablet dosage form. The estimation was carried out on a HIBAR (Lichrospher C-18) column with the dimensions of 250mm x 4.6mm, 5µm. Combination of Acetonitrile and 0.5% Potassium dihydrogen ...
4143
1180
DESIGN, SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2-{[(2E)-3-(3, 4, 5-MONO/DI/TRI HYDROXYPHENYL) PROP-2-ENOYL] SULFANYL/AMINO} PROPANOIC ACIDS IN HUMAN PLASMA BY ROTOR GENE-Q (5 PLEX) REAL TIME PCR METHOD
Halfmer of chicoric acid derivatives in two series were planned to synthesized and evaluated for their capacity to reduce the viral load in the human plasma by ROTOR GENE-Q (5 Plex) Real Time PCR method to check their biological activity. Different substituted hydroxy cinnamic acids has been conjugated with different amino acid in N-series and in K-Series same substituted hydroxy cinnamic acids ha...
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ANTIMICROBIAL ACTIVITY OF ESSENTIAL OILS AGAINST FOOD-BORNE PATHOGENIC BACTERIA
The increasing resistance of microbes to conventional drugs has promoted the scientists to search for new biocides with broad activity. Plant derived essential oils (EOs) have been known to show antimicrobial activity against specific pathogens and therefore could be considered as alternative antimicrobial agents in controlling pathogens. The present study was done to investigate the antimicrobial...
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SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL SCREENING OF SOME TRANSITION METAL COMPLEXES WITH SUBSTITUTED ACETOPHENONE THIOSEMICARBAZONE
Complexs of Fe, Cu and Zn have been prepared by reacting metal chloride\sulphate with p-hydroxyacetophenone thiosemicarbazone, p-fluoroacetophenone thiosemicarbazone, p-bromoacetophenone thiosemicarbazone as ligands and their complexes were screened for their IR, NMR, and antifungal and antibacterial studies. . Acetophenone thiosemicarbazone ligands were prepared by the reaction of substituted ace...
3327
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STUDY OF ENDOPHYTIC FUNGAL COMMUNITY OF MORINGA OLEIFERA FROM OMALUR REGION – SALEM
Endophytic fungi are ubiquitous in nature residing inside all the plant species contributing to their host plants by producing a plenty of substances that provide protection and survival value to the plant. Many researchers have proven that endophytes are a new and potential source of novel natural products for exploitation in modern medicine. This present study is undertaken to isolate and identi...
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AFFECT OF GRANULE SIZES, TYPES AND CONCENTRATIONS OF LUBRICANTS AND COMPRESSION FORCES ON TABLET PROPERTIES
By using five different sieve sizes of ascorbic acid granules, affects of granule sizes on tablet properties, i.e. tablet weight and hardness have been studied with standard methods. Affects of lubricant types and concentrations on tablet properties, i.e. tablet hardness and disintegration time have also been studied by using magnesium stearate and sodium stearyl fumarate as the lubricants for pro...
7042
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EVALUATION OF ANTIBACTERIAL ACTIVITY OF APIS HONEYS FROM PADERU FOREST DIVISION IN ANDHRA PRADESH INDIA
Antibacterial activity of the two honey samples produced by the honey bee (Apis florea), was standardized by Disc diffusion method. The two honey samples were tested at three concentrations (5, 10 and 15µl v/v) and zone of inhibition were measured against Staphylococcus aureus, Escherichia coli, Basillus subitis, Pseudomonas putida and Klebsiela pneumonia; unifloral and multifloral honey samples ...
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EVALUATION OF GRASS SPECIES FOR ELEMENTS THROUGH ICP-OES TECHNIQUE
The aim of the study is to screen the grasses of South India for mineral nutrition. The results revealed that the grass species accumulate the major and minor elements at different concentrations. The maximum concentration (ppm) of macroelements in the analysed samples were 12270, 31310, 5309 and 3946 for Ca, K, Mg and P respectively. The maximum concentrations (ppm) of microelements were 50.05, 8...
3267
1560
A pH-GRADIENT SAX-HPLC METHOD FOR DETERMINATION OF TRACE LEVELS OF OVER SULFATED CHONDROITIN SULFATE AND DERMATAN SULFATE IN HEPARIN SODIUM
A rapid and sensitive pH-gradient SAX HPLC method for the determination of Dermatan sulphate (DS) and trace levels of Oversulphated chondroitin sulphate (OSCS) in Heparin sodium was developed and validated. A pH gradient was opted to strike a balance between resolution and sensitivity because the response of OSCS was found to be better at neutral pH and the resolution between DS and Heparin was go...
5495
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SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF GLIBENCLAMIDE IN PURE FORM AND IN DOSAGE FORM
Two simple, sensitive and rapid spectrophotometric methods was developed for estimation of glibenclamide in pure and in pharmaceutical dosage forms. Method-A is a uv spectroscopic method with the absorption maxima at 276nm.Method-B is based on the oxidation/reduction of glibenclamide with iron (III) and chelation of iron with 3-methyl 2-benzothiozoline hydrazone(MBTH) to form green colored complex...
4734
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ANTIOXIDANT STUDIES, ERYTHROCYTE MEMBRANE STABILIZATION AND THROMBOLYTIC POTENTIAL OF DIALLYL DISULPHIDE
Diallyl Disulphide is an essential component of garlic which has numerous medicinal applications. Thus it was evaluated for its free radical scavenging potential. The compound was assayed for its ability to stabilize the erythrocyte membrane by osmotic fragility test and heat induced hemolysis assay. The thrombolytic potential was evaluated by the ability of the compound to dissolve the clot forme...
3267
1137
STUDY OF ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL EVALUATION OF JATROPHA GOSSYPIFOLIA, SAPIUM SEBIFERUM, KIRGANELIA RETICULATA, PHYLLANTHUS FRATERNUS AND PEDILANTHUS TITHYMALOIDES
Present investigation deals with the evaluation of the antimicrobial activity of extracts of Jatropha gossypifolia Linn., Sapium sebiferum (L.) Roxb., Kirganelia reticulata (Poir) Baill., Phyllanthus fraternus Webster and Pedilanthus tithymaloides (Linn.) Poit. against Escherichia coli, Proteus vulgaris, Staphylococcus aureus and Bacillus cereus and Trichophyton mentagrophytes and T. rubrum. The a...
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ANTIBACTERIAL ACTIVITY OF MEDICINAL PLANT AGAINST WOUND INFECTED PATHOGENS
Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. The effects of plant extracts on bacteria have been studied by a very large number of researchers in different part of the world. In this study antimicrobial activity of Acalypha indica were investicated against two strains of Human pathogenic bacteria. A total of 15 pus samp...
6158
1501
DRUG PRESCRIBING PATTERNS DURING ANTENATAL CARE IN A TERTIARY CARE RURAL TEACHING HOSPITAL: A CROSS-SECTIONAL STUDY
Context: Drug treatment during pregnancy presents a special concern. All drugs should not be avoided. A better knowledge of parameters that determine teratogenicity may allow the physicians gain confidence. Aims: This study was conducted to understand the drug utilization practices during pregnancy in women from rural areas and poor socioeconomic background; classify them according to US-FDA categ...
3463
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SYNTHESIS OF NOVEL SERIES OF 2-AMINO-1, 2-DIHYDROISOQUINOLINE-3(4H)-ONE DERIVATIVES USED AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS
A facile synthesis of novel 2-amino-1,2-dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yield. The structure of all novel synthesized compounds was established based on Mass, 1H NMR, 13C NMR, ...
3026
1024
FORMULATION CHARACTERIZATION AND IN-VITRO DIFFUSION STUDIES OF HERBAL EXTRACT LOADED MUCOADHESIVE BUCCAL PATCHES
The present paper deals with a novel approach in formulating and characterizing mucoadhesive buccal patches with the incorporation of herbal extract. In the present arena of Novel Drug Delivery System, delivery of drugs through buccal mucosa serves an easier method for utilization of drugs leading to reduction of dose frequencies and thereby tends to sustain the drug release. Buccal patches were p...
4141
2041
BIOLOGICAL STUDIES OF THE BARK OF ALBIZIA LEBBECK (L.) BENTH
The phytochemical screening of the bark of Albizia lebbeck (L) showed positive test for tannin, alkaloid, flavonoid, terpenoid, phlabotannin, saponin, steroid and cardiac glycoside. In this article an attempt was made for biological studies (the antimicrobial activity, cytotoxicityand free radical-scavenging activity) of different extracts (hexane, methanol, ethyl acetate, water and buta...
5827
1568
IN-VITRO CYTOTOXIC ACTIVITIES OF LEAF EXTRACT OF GARDENIA LATIFOLIA AIT. AND GARDENIA GUMMIFERA LINN.
Plants are the natural reservoir of many anticancer agents. Gardenia latifolia Ait. and Gardenia gummifera Linn. belonging to the family Rubiaceae. Gardenia Ellis. is a genus of 142 species, which occur in tropical and sub-tropical regions of Africa, South Asia, Australasia and oceania. The genus was named by Carl Linnaeus after Dr. Alexander Garden (1730-1791), a Scottish-born American naturalist...
4192
1642
ATTENUATION OF HYPERGLYCEMIA AND OXIDATIVE STRESS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS BY AQUEOUS EXTRACT OF AVERRHOA BILIMBI LINN FRUITS
In the present study, the antidiabetic and antioxidant effect of aqueous extract of Averrhoa bilimbi Linn (ABAE) fruits were evaluated. Diabetes mellitus was induced in male Sprague Dawley rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). Oral administration of aqueous extract of Averrhoa bilimbi Linn (ABAE) (50mg/kg body weight) and metformin (100 mg/kg body wei...
3063
1331
TWO NEW METABOLITES; 7β-OH-UZARIGENIN AND 7β-OH-ODOROSIDE-H; THROUGH BIOTRANSFORMATION OF UZARIGENIN AND ODOROSIDE-H
Two new cardenolide metabolites, 7β-OH-uzarigenin (1M) and 7β-OH-odoroside-H (2M) were obtained through the biotransformation of uzarigenin (1) and odoroside-H (2). Compounds 1 and 2 were isolated from the air-dried roots of Nerium oleander L. The plant, belonging to family Apocynaceae, was collected in October, 2010 from Mansoura university garden in Egypt. The methylene chloride extract of the...
6872
911
ESTIMATION OF (-)-HYDROXYCITRIC ACID (HCA) IN GARCINIA LANCEAEFOLIA ROXB. USING NOVEL HPLC METHODOLOGY
ABSTRACT: (-)-Hydroxycitric acid (HCA) has been found to be the principal acid in genus Garcinia, which is a potential metabolic regulator of anti-obesity activity and inhibitor of lipogenesis. Presence of (-)-HCA as the principal acid has added importance to thegenus Garcinia. The present study deals with extraction and estimation of (-)-HCA from Garcinia lanceaefolia,collected from four administ...
7034
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IN-VITRO ANTI-INFLAMMATORY STUDIES IN CLEOME VISCOSA L. AND CLEOME BURMANNI W. & A. (CLEOMACEAE)
The present study evaluates the anti-inflammatory potential of the methanol and chloroform extracts of Cleome viscosa and C. burmanni by in-vitro methods.The anti-inflammatory property of the extracts was assessed using albumin denaturation assay, proteinase inhibitory activityand hyaluronidase inhibition assay and the results compared against reference drugs such as Aspirin and Indomethacin. The ...
4768
1847
SYNTHESIS AND BIOCIDAL ACTIVITY OF Co (II) AND Zn (II) COMPLEXES OF SULFA DRUG SCHIFF BASES
The novel Co (II) and Zn (II) complexes have been synthesized by reaction of CoCl2/ZnCl2 with Schiff bases of benzoyl derivative of 3-methyl-1-phenyl-2-pyrazoline-5-one and sulfa drugs in 1:2 ratio. The synthesized complexes were screened/tested for their antimicrobial activity against pathogenic bacterial strains i.e. E. coli, Staphylococcus aureus strain I, Staphylococcus aureus strain II, Staph...
3526
1169
ANTI-BIOFILM ACTIVITY OF EUCALYPTUS GLOBULUS OIL ENCAPSULATED SILICA NANOPARTICLES AGAINST E. COLI BIOFILM
The inhibitory effect of Eucalyptus globulus oil was evaluated against the E. coli and the minimum inhibitory concentration (MIC) value of Eucalyptus globulus oil was calculated by agar dilution assay, which was found to be 1µl/ml. The E. coli biofilm was formed on catheter surface and quantified by crystal violet staining system. The crystal violet quantification method showed maximum biofilm af...
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1427
FORMULATION AND EVALUATION OF NIFEDIPINE LOADED CHITOSAN MICROSPHERS FOR MUCOADHESIVE DRUG DELIVERY
Nifedipine loaded mcoadhesive micropshres were prepared by o/w/o emulsification cross linking method using natural polymer chitosan. Microsphres with particle size range b/n 50-300 µm were obtained by this method. The prepared microspheres were evaluated for its drug loading, surface properties, in-vitro release profile. The diffusion and permeation characteristic of the drug is studied by using ...
3611
1223
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3β INHIBITORS AS ANTIDIABETIC AGENTS
To synthesize structurally modified novel Glycogen Synthase Kinase-3βinhibitors to overcome insulin resistance in type 2 diabetes mellitus and to overcome associated health problems with reducing morbidity, mortality and economic costs of diabetes. Methods. Nineteen Phenylmethylene hydantoin analogs were designed and docked in the ATP binding site of GSK-3β by Molegro Virtual Docker 2006.1.5...
7302
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EXPLORING THE POSSIBLE MECHANISM OF ALBIZIA LEBBECK COMPONENTS BINDING WITH DRUG TARGETS OF BRONCHIAL ASTHMA –AN INSILICO AND CLINICAL ANALYSIS
Asthma is a multi factorial disease characterized by airflow obstruction, wheezing and dysonea and for this many genes are responsible. In this study, an attempt has been made to identify genes along with the proteins encoded by them which are responsible for Asthma along with clinical trials. In the practice of Ayurveda, it’s well established that shirish (Albizia lebbeck) can be used as a trea...
3955
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SYNTHESIS OF SOME 2, 3-DIARYL-6-ISOXAZYL-QUINOLINE-4-CARBOXYLIC ACID DERIVETIVES
A series of some new substituted quinolines were synthesized by Doebner reaction, a three component coupling of various aromatic amines with two aldehydes and phenyl pyruvic acid, the intermediate 2, 3-diary-6-acetyl-quinoline-4-carboxylic acids were reacted with various aromatic aldehydes in the presence of basic medium using Claisen-Schmidt condensation in order to afford the corresponding chalc...
3154
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EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM AND SYNTHESIS OF ITS DERIVATIVES: COMPARATIVE EVALUATION OF ANTI-OXIDANT ACTIVITIES
The objective of this study was to extract ursolic acid (UA) from Ocimum sanctum,to synthesize its derivatives and to examine the improvement of antioxidative activity. Present work involved structural modification of UA at the C-3 and C-28 positions. UA derivatives namely UA-4 and UA-7 with distinct property were synthesized. Comparative evaluation of anti-oxidant activity of UA, UA-4 and UA-7 us...
3415
1031
HALOGENATED TRIAZINEDIONES BEHAVE AS ANTAGONISTS OF PKR1: IN-VITRO AND IN-VIVO PHARMACOLOGICAL CHARACTERIZATION
Different prokineticin receptor antagonists, based on the triazinedione scaffold, were synthesized by a new efficient method. Here we demonstrated that 5-benzyl triazinediones substituted in position para of the benzyl group with halogens provide compounds endowed with interesting selectivity for the Prokineticin receptor 1 (PKR1). BRET technology indicates that such substitution results in increa...
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914