Volume 8 (2017) - Issue 12, December
BENZOTHIAZOLE – A MAGIC MOLECULE
Antimicrobial resistance has been called one of the world's most pressing public health problems. Addressing the issue of antimicrobial resistance is one of the most urgent priorities in the fields of public health today. Alarmingly, the development of resistance such as multi-drug resistance towards a number of antibiotics poses a challenge to the scientific community in the discovery of new ther...
A COMPREHENSIVE REVIEW ON HERBAL COSMETICS
India is a focus for development of Ayurveda, Unani, Siddha, Homoeopathy and another natural herbs based health science (AYUSH). Ayush Pharmaceutical industry having great possible and contingency for saundarya prasadka category (herbal cosmetic) development in future. Natural beauty is blessing and cosmetics help in presenting and increaning the beauty and personality aspects of human beings. Sau...
BIOMEDICAL APPLICATIONS OF CERAMIC NANOMATERIALS: A REVIEW
A variety of Nano-biomaterials are synthesised, characterised and tested to find out their potentialities by global scientific communities, during the last three decades. Among those, nanostructured ceramics, cements and coatings are being considered for major use in orthopaedic, dental and other medical applications. The development of novel biocompatible ceramic materials with improved biomedica...
ALZHEIMER’S DISEASE: A CHALLENGE IN MANAGING WITH CERTAIN MEDICINAL PLANTS – A REVIEW
It is well known that some plants have medicinal properties and their knowledge has been accumulated in the course of many centuries, based on different medicinal systems such as Ayurveda, Unani and Siddha. In India, it is reported that traditional healers use nearly 2,500 plant species and 100 plant species serve as regular sources of medicine for the treatment of various diseases. Alzheimer’s ...
ROLE OF CHITOSAN AND EUDRAGIT IN POLYMER – BASED EXTENDED RELEASE MATRIX TABLETS – A REVIEW
The present article describes the recent role of polymers as carriers for delivery of drug at target site to extending its release. These polymers are widely used in delivery due to their inherent characteristics such as biocompatibility, biodegradability. Chitosan and Eudragit are choice of drug in extended release matrix tablets. Chitosan is an amino polysaccharide polymer which is biodegradable...
A REVIEW ON NANOPARTICULATE MUCOADHESIVE SYSTEM
Peptide drugs are poorly absorbable and are also susceptible to enzymatic degradation in the gastrointestinal tract (GIT). To overcome the physiological and morphological barriers for the peptide / poorly absorbable drug delivery, mucopenetrative and mucoadhesive properties of drug carriers have to be considered. Mucoadhesion can prolong the residence time of drug carriers at the absorption sites,...
PEPTIDOMIMETICS AS A CUTTING EDGE TOOL FOR ADVANCED HEALTHCARE
With exponential advancements in healthcare and pharmaceutical sciences, Peptidomimetics have emerged as essential tools in the designing and development of novel and improvised therapeutics. The peptidomimetic based drugs are designed with the aim of overcoming the shortcomings of natural peptides and proteins. Thus, peptidomimetic therapeutics possesses increased efficiency, stability and overal...
A SYSTEMATIC REVIEW ON DIAGNOSIS AND MANAGEMENT OF POSTMENOPAUSAL OSTEOPOROSIS
The aim of this review is to assess the efficacy of treatments for postmenopausal osteoporosis in women with low bone mass or with an existing vertebral fracture. Osteoporosis is a worldwide health problem related to the aging of the population, and it is often under diagnosed and undertreated. It is related to substantial morbidity, mortality and impairment of the quality of life. Estrogen defici...
MANAGING ALLERGIC RHINITIS IN CHILDREN THROUGH AYURVEDIC HERBAL MEDICINES
Allergic Rhinitis (AR) represents a common and serious health problem in pediatric age group in term of outpatient visit. The chronic nature of disease and its association with other comorbid conditions like asthma, eczema etc. has shown significant negative impact on quality of life, school performance and cognitive functioning in children which has influenced many parents to seek alternative the...
REVIEW ON COMPARATIVE GENOMICS FOR MYCOBACTERIUM TUBERCULOSIS STRAINS
Tuberculosis caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (MTB) strains is a growing problem in many countries. The availability of the complete nucleotide sequences of several MTB genomes allows to use the comparative genomics as a tool to study the relationships of strains and differences in their evolutionary history including acquisition o...
SEMI-BATCH AND CONTINUOUS CARBOCHLORINATION OF ZIRCONIA IN A PILOT PLANT FLUIDIZED BED REACTOR: OPTIMIZATION OF OPERATING CONDITIONS VIA RESPONSE SURFACE METHODOLOGY
Zirconium tetrachloride was produced in a pilot plant fluidized bed reactor via the carbochlorination reaction of zirconia. Minitab software 17 was used for the design of experiment with response surface methodology (RSM) for both semi batch and continuous processes. The operating temperature (800-1200 °C), reaction time (30-90 min) and mean particle size (MPS) (70-130µm) were chosen as the rang...
EFFECTS OF SURFACTANT TYPE ON RETENTION OF BIOACTIVE COMPOUNDS OF SYZYGIUM AROMATICUM IN SPRAY DRIED LIPID BASED SYSTEMS
This work investigates the effects of the surfactant system used and of spray drying temperature in physicochemical properties and retention of bioactive compounds of lipid based systems loaded with bioactive compounds of Syzygium aromaticum. Seven formulations were prepared, containing Compritol 888 ato and buriti oil as lipids and maltodextrin DE10 as wall material. The surfactants Poloxamer 188...
DIETARY HYPERCHOLESTEROLEMIA INDUCES OXIDATIVE STRESS CHALLENGING SPERMATOGENESIS IN RAT MODEL: A LINK TO POSSIBLE INFERTILITY
Background: Hypercholesterolemia is rapidly becoming a worldwide epidemic that affects children and adults. Some attempt had made to generalize a relationship between hypercholesterolemia and infertility, but until now it remains scanty. Thus, the aim of the present study was initiated. Methods: Male Wistar rats were divided into four groups of six each (n=6). The first group was control and secon...
IMPORTANCE OF CALIBRATION IN FLOW CYTOMETRY ANALYSIS FOR HUMAN ADIPOSE TISSUE – DERIVED STEM CELL CHARACTERIZATION
Human adipose tissue-derived stem cells (hADSCs) are promising for cellular therapy as they are multipotent, which consistently express high CD90, CD105, CD73 and low hematopoietic surface markers. Flow cytometry is a routine technology that is used in most laboratories and can be used to study hADSC characterization, but the instrument needs strict calibration to assure the quality of the results...
MOLECULAR MODELLING AND MOLECULAR DYNAMICS STUDIES OF SPECT PROTEIN OF PLASMODIUM FALCIPARUM AND IN SILICO SCREENING OF LEAD COMPOUNDS
Malaria has been a major life threatening mosquito borne disease. Unavailability of any effective vaccine and recent emergence of multi drug resistant strains of malarial pathogen Plasmodium falciparum continues to cause persistent deaths in the tropical and sub-tropical region. As a result, there is a growing demand for new targets for more effective anti-malarial drugs. A novel microneme prot...
STRUCTURAL DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NEWLY SYNTHESIZED SCHIFF BASE DERIVED QUINAZOLINONE DERIVATIVES
Present studies describe the synthesis of a series of Schiff base derived quinazolinone derivatives (6-14) with the aim to have better anti inflammatory agents. The prepared compounds were characterized using chemical and spectral (IR, NMR and Mass) studies. Pharmacological evaluation of the newly synthesized derivatives indicated that compounds 8, 11 and 14 exhibit significant anti-inflammatory...
GREEN SYNTHESIS OF SILVER NANOPARTICLES USING TABERNAEMONTANA DIVARICATA AND IN-VITRO CYTOTOXICITY INVESTIGATION AGAINST HUMAN LUNG ADENOCARCINOMA
The present study aims to synthesize highly stable and dispersed cytotoxic silver nanoparticles (AgNPs) from Tabernaemontana divaricata (T. divaricata) leaves extract, by using noble green approach at room temperature. Phytocomponents were investigated using general methods and found good agreement with reported literature. Green synthesized AgNPs were characterized using UV-Vis, FT-IR, XRD, TGA, ...
QUALITY-BY-DESIGN APPROACH FOR DEVELOPMENT AND OPTIMIZATION OF NEFOPAM HYDROCHLORIDE LOADED POLY-(ε-CAPROLACTONE) AND POLY-3-HYDROXYBUTYRATE MICROSPHERES
The objective of present study was to investigate optimized nefopam hydrochloride loaded microspheres (NPH-MS) by investigating the relationship between independent and dependent variables using response surface methodology. Central composite design with thirty three batches was constructed using drug: polymer (X1), PHB: PCL (X2), stirring speed (X3), stirring time (X4) and polyvinyl alcohol (PVA)...
EFFECT OF DIAZEPAM AND BICUCULLINE IN BODY WEIGHT REGULATION: POSSIBLE ROLE OF GABA TYPE A RECEPTOR
Arcuate nucleus GABAergic system plays an important role in the energy balance evidenced by various studies. The present study was designed to investigate the involvement of GABA type A receptor in experimental obesity. In the present study effects of chronic administration of diazepam (0.5 and 1mg/kg/day, i.p) and bicuculline (0.6 and 1.25mg/kg/day, i.p) specific GABA type A receptor agonist and ...
MOLECULAR DOCKING STUDIES OF CANTHIN-6-ONE FROM SIMAROUBA GLAUCA AGAINST EGFR TYROSINE KINASE
In recent years, in silico approaches have been predicting novel drug targets. The objective of this study was to analyze the inhibitory action of canthin-6-one alkaloid by computational docking studies. For this study, natural metabolite canthin-6-one isolated from Simarouba glauca was used as ligand for molecular interaction. The crystallographic structure of molecular target Epidermal Growth Fa...
ANTI-INFLAMMATORY AND ANTIBACTERIAL POTENTIAL OF CARISSA CARANDAS AND CARISSA SPINARUM NANOEMULSIONS
The studies in the present article aims at developing an optimal oral polyherbal nanoemulsions from Carissa carandas (CC) and Carissa spinarum (CS) which are noticed in ethnobotanical herbarium for their pharmacological relevance. Nanoemulsions were developed in different proportions of oil and surfactant systems in order to enhance its oral bioavailability. Solubility studies were carried out for...
PREDICTIVE QSAR ANALYSIS OF FLAVONOID ANALOGUES AS ANTIPSORIATIC AGENTS
Objective: Newly designed antipsoriatic agents which are substituted series of analogues of flavonoids (kaempferol and quercetin) that belong to the subclass flavonols were subjected to (2D-QSAR) analysis using VLIFEMDS-QSARPro software with an intention to derive and understand the possible correlation of biological activity as dependent variable and other descriptors like molecular weight, XLogP...
SCREENING OF ANTIMICROBIAL PROPERTIES OF PHENOL SCHIFF BASES
In their fight for supremacy and survival, microorganisms have been developing and devising various methods to inactivate the action of antibiotics. The numbers of drug resistant microorganisms with reduced susceptibility to various antibiotics are increasing. Therefore, new infection-fighting strategies are required to control microbial infections. The interaction between potent chemicals and liv...
SIMPLE AND RAPID SPECTROPHOTOMETRIC DETERMINATION OF ATENOLOL AND ESMOLOL β-BLOCKERS IN PHARMACEUTICAL FORMULATIONS AND SPIKED WATER SAMPLES
Atenolol and esmolol drugs belonging to a β–blocker group are frequently used for the treatment of cardiovascular diseases. These drugs are also charged as water pollutants. A new simple and rapid spectro-photometric method has been developed for their determination in pharmaceutical formulations and in spiked water samples. The proposed method is based on the derivatization of the amino functi...
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS ANALYSIS OF ISOPROPAMIDE AND TRIFLUOPERAZINE IN FIXED-DOSE COMBINATION TABLETS
A simple, precise isocratic stability indicating RP‐HPLC method was developed for the determination of isopropamide and trifluoperazine in pure and its pharmaceutical formulations. In the developed method, methanol, acetonitrile and water in the ratio of 40:30:30 (v/v) as mobile phase and Waters C-18 (250mm x 4.6mm, 5μm) column as stationary phase were used. The flow rate and detection waveleng...
FORMULATION OF VALUE ADDED LOW-CALORIE, HIGH FIBRE BISCUITS USING FLAX SEEDS AND STEVIA REBAUDIANA
Worldwide scientists are focusing on developing functional food products which are healthy and low in calories. The possibility of incorporating roasted flax seeds flour (RFF) and substituting sugar with Stevia rebaudiana leaves powder (SLP) for developing nutritious, healthier and high quality biscuits has been investigated. Overall six biscuit formulations were designed besides control. SLP was ...
PREGNANE – A PARENT OF PROGESTERONE FROM TRIGONELLA FOENUM – GRAECUM LINN.
There are some herbal contraceptives that have the property to avoid the embryo implantation. Trigonella foenum-graecum Linn. is used in folk medicine as alcoholic and aqueous preparations for prevention of pregnancy. Pregnane- progesterone is one of the important steroid has direct connection with contraceptive activity. Pregnane is a C21 steroid and indirectly, a parent of progesterone. The ...
ANTIOXIDANT ACTIVITY OF ETHYL ACETATE EXTRACT OF GENUS AMARANTHUS LINN.
Plants possess good antioxidant capacity to get rid of free radicals that cause many lifestyle diseases especially cancer. Assessment of Antioxidant activity of Amaranthus Linn. leaves were evaluated by using in- vitro model. In the present study evaluation of ethyl acetate of extract of Amaranthus Linn. leaves with the help of two In-vitro antioxidant models were carried out for Nitric-oxide sc...
DETECTION OF ANTI-QUORUM SENSING ACTIVITY OF ROSEMARINUS OFFICINALIS AND VALERIANA OFFICINALIS USING MICROBIAL BIOSENSOR STRAIN
Quorum-sensing is a phenomenon in which bacteria exhibit several density dependent phenotypes. Quorum-sensing is achieved through production of auto - inducer which on acquiring a threshold concentration, activates the genes, bringing into effect the concerned phenotypes. Ayurvedic medicinal plant extracts are being used to treat a plethora of infectious disease and are known to be rich in phytoch...
ASSESSMENT OF POTENTIAL EFFECT OF ANTIEPILPETIC DRUGS ON LIPID PROFILE AND C-REACTIVE PROTEIN AS PREDICTORS OF VASCULAR DISEASE IN EPILEPSY PATIENTS
Epilepsy is a neurological disorder which often requires lifelong treatment with antiepileptic drugs (AEDs). Prolonged use of AEDs is associated with changes in vascular risk markers. Hence, the study was designed to evaluate the effect of older generation AEDs (carbamazepine and phenytoin) and newer generation AED (levetiracetam) monotherapy on the markers of vascular risk in epilepsy patients. T...
IN VIVO ANTI-INFLAMMATORY ACTIVITY OF ETHYL ACETATE EXTRACT DERIVED FROM MARINE STREPTOMYCES CARPATICUS
Anti-inflammatory activity of the SC-EA extract of the marine Streptomyces carpaticus was studied in Wistar rats using acute and chronic inflammatory models like carrageenan induced paw edema and cotton pellet induced granuloma models respectively. The acute toxicity of SC-EA extract was tested on adult Wistar rats. The maximum dose of SC-EA extract at 2000mg/kg does not show any sign of visual ch...
IN VIVO AND EX VIVO EVALUATION OF LUFFA ACUTANGULA FRUIT EXTRACT AND ITS FRACTIONS FOR HEPATOPROTECTIVE ACTIVITY IN WISTAR RATS
The alcoholic extract of fruits of the plant Luffa acutangula previously reported for is hepatoprotective activity was fractionated into three parts to chemically identify the most potent bioactive fraction. The hepatoprotective potential of the fraction prepared from extract was studied in vivo in rats as well as ex vivo in isolated hepatocytes against paracetamol induced hepatotoxicity. The hepa...
PHYTOCHEMICAL ANALYSIS AND ANATOMICAL STUDY OF TWO SPECIES OF CESTRUM FROM CHANDIGARH
Family Solanaceae is known for its tropane alkaloids which have many medicinal properties. In our study two Cestrum species namely Cestrum diurnum and Cestrum nocturnum which are also ornamental plants are studied as different parts of the plants possess anti-bacterial, anti-malarial, analgesic, anti-inflammatory, inhibitory effect on central nervous system and wound healing properties. The presen...
BIOSYNTHESIS OF SILVER NANOPARTICLES FROM HIBISCUS ROSA SINENSIS: AN APPROACH TOWARDS ANIMICROBIAL ACTIVITY ON FISH PATHOGEN AEROMONAS HYDROPHILA
Aeromonas hydrophila is a gram negative bacterium which is primary or secondary cause of ulcers and hemorrhagic septicaemia in fish. The treatments for this infection are only restricted to some antibiotics. So, novel materials are being searched for combating with bacterial infections and the resulting consequences. In this presence study, the green synthesized silver nanoparticles using Hibiscus...
ANTIMICROBIAL RESISTANCE OF STAPHYLOCOCCUS AUREUS AMONG HEALTHY AND ADULT STUDENTS
Background: Antimicrobial resistance against S.aureus infections is a global public health problem resulting in very limited treatment options, and inappropriate use of antibiotics is one of the most important factors that could affect the increasing pattern of resistance. Objective: To determine the antimicrobial resistance pattern of S. aureus among healthy and adult students to commonly used an...
A STUDY ON PHYSICAL, CHEMICAL, AND ANTIOXIDANT PROPERTIES OF ESSENTIAL OIL SEPARATED FROM FRESH BERRIES OF CINNAMOMUM RIPARIUM BY STEAM DISTILLATION TECHNIQUE
Cinnamomum riparium Gamble belongs to the family Lauraceae is a red listed species by the International Union for Conservation of Nature (IUCN). It is a tree growing in evergreen forests and traditionally used for treating conditions like wound healing, fever, intestinal worms, headache, inflammations, menstrual problems etc. According to tribal’s, this activity is mainly due to the volatile oil...
PROSPECTIVE STUDY ON ROLE OF CRP AS AN INFLAMMATORY MARKER IN TYPE-II DIABETES MELLITUS IN TERTIARY CARE HOSPITAL
Globally at present, there are an estimated 366 million people affected with diabetes mellitus. The Indian figure is around 61.3 million diabetics, which is projected to cross 100 million by the year 2030. Owing to rise of diabetes mellitus cases, the economic burden due to diabetes in India ranks the highest in the world. With the increasing prevalence of diabetes, it has resulted in an increase ...
RAPID, SENSITIVE METHOD FOR THE DETERMINATION OF CINNARIZINE IN PLASMA BY LC-MS/MS AND IT’S APPLICATION TO PHARMACOKINETIC STUDY
Bioavailability of orally administered cinnarizine is typically low and variable due to high incidence of degradation. Many methods are available in public domain for the determination of Cinnarizine in plasma by RP-LC method but none published a LC-MS/MS method. Our objective is to develop a simple, rapid, sensitive bioanalytical method for the determination of Cinnarizine in human plasma by LC-M...
SCREENING OF PHYTOCHEMICALS, ANTIOXIDANT AND INHIBITORY EFFECT ON ALPHA-AMYLASE BY ETHANOLIC EXTRACT OF ELAEOCARPUS GANITRUS (BARK)
Elaeocarpus ganitrus Roxb is widely used in traditional medicine to cure various diseases. In this present study, the phytochemical constituents, antioxidant activity and inhibitory effect on alpha amylase by the ethanolic extracts of the Elaeocarpus ganitrus (bark) were investigated. The dried bark of Elaeocarpus ganitrus was extracted by using ethanol as a solvent for extraction with the help of...
BIOCHEMICAL CHARACTERIZATION OF PROTEASE FROM ZINGIBER OFFICINALE RHIZOME BY USING NEURAL NETWORKING APPROACH
Biochemical characterization of enzyme is the most fundamental aspects of enzymology from industrial point, as it is desirable to choose an enzyme which will have the fastest reaction rate per unit amount of enzyme which indicates the maximum effect for the minimum amount of added catalyst. In this study, Protease enzyme was extracted from Z. officinale and purified by using various down streaming...
DETERMINATION OF TOTAL FLAVONOID AND PHENOL CONTENT IN MIMUSOPS ELENGI LINN.
Objective: To study qualitative and quantitative estimation of phytochemicals and determination of total phenol and flavonoid content in plant parts of Mimusops elengi Linn. Methods: The solvents methanol, ethanol, aqueous and petroleum ether are used for extraction of Mimusops elengi Linn. plant parts. Phytochemical screening of plant parts was carried out in all the solvents. Quantitative estima...
EFFECTIVENESS OF VARMAM THERAPY FOR THE MANAGEMENT OF OSTEOARTHRITIS
Siddha system of medicine is the ancient traditional medicine practiced all over Tamil Nadu. Siddha system is bestowed with various specialities of few which are Varmam, Pranayamam, Yoga and Kayakarpam. This system has a vast repository of internal and external medicines; Varmam is one among such therapies used to treat multiple ailments, especially related to musculoskeletal and neurological defi...
ASSESSMENT OF DRUG UTILIZATION PATTERN AND TERATOGENICITY RISK AMONG PREGNANT WOMEN ATTENDING A TERTIARY CARE HOSPITAL, ANDHRA PRADESH
Objectives: The aim of this study was to assess the drug utilization pattern and teratogenicity risk among pregnant women attending a tertiary care hospital, Andhra Pradesh. Materials and Methods: A cross-sectional observational study was carried out on antenatal women (total=1163) more than 18 years of age attending the antenatal clinic of Obstetrics and Gynaecology (OBG) Department. Demographic ...
CYTOTOXIC ACTIVITY OF JUSTICIA WYNAADENSIS (NEES) T. ANDERSON LEAF EXTRACT ON HUMAN CANCER CELL LINES
Justicia wynaadensis, an endemic medicinal plant found in the regions of Western Ghats is a herb, belonging to the family Acanthaceae. The following study was carried out to evaluate the in vitro cytotoxicity of the leaf extract of Justicia wynaadensis. Four different extracts were prepared by using water and methanol [aqueous fresh leaves extract, methanolic extract of dry leaves powder, hot (boi...
PROSPECTIVE STUDY ON DRUG-DRUG INTERACTIONS OF NARROW THERAPEUTIC INDEX DRUGS
Drug interaction generally refers to a modification of the expected drug response in the patient as a result of exposure of the patient to another drug or substance. Some unintentional drug interactions produce adverse reactions in the patient, whereas some drug interactions may be intentional, to provide an improved therapeutic response or to decrease adverse drug effects. They are divided into t...
PREPARATION AND EVALUATION OF ANTIMICROBIAL HERBAL FORMULATION OF PTEROSPERMUM ACERIFOLIUM WILLD.
The present work deals with formulation of topical gels containing aqueous extract of P. acerifolium seeds and also to evaluate the prepared gels against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various P. acerifolium seed extracts was measured through determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffu...
PHYTOCHEMICAL ANALYSIS AND DPPH ANTIOXIDANT ACTIVITY OF TWO TRADITIONALLY USED PLANTS OCCURRING AT PURULIA DISTRICT OFWEST BENGAL, INDIA
The objectives of the present study were to evaluate the preliminary phytochemical analysis (quantitative and qualitative) and DPPH antioxidant activity of two traditionally important plants occurring at Purulia district of West Bengal in India. Qualitative analysis of phytochemicals (flavonoid, alkaloid, terpenoids, saponins, phenol and carbohydrate) and quantitative analysis of total phenolics a...
AN OBSERVATIONAL STUDY ON ENDEMIC DISEASES IN MULTISPECIALITY HEALTH CARE SYSTEM
Background: A cross sectional study, to determine the endemicity, by systematic investigations in institutional settings to assess the prevalence of diseases. Methods: The study was conducted by observational method over a period of seven months regarding the prevalence of particular disease and disease with co-morbidities. Among the several diseases of distinct clinical spectrum, various risk f...
HERBAL MEDICINES USED DURING PREGNANCY, CHILDBIRTH AND POSTPARTUM CARE
Pregnancy and childbirth have been an essential part of human existence for millennia, but unfortunately the experience has not been easy for all women. Although many pharmaceutical drugs are available but the potential of drugs to cause harm, exemplified by thalidomide in 1958 cannot be ignored. Therefore, many pharmaceutical drugs are not recommended for use during pregnancy either because of kn...
PHYTOCHEMICAL SCREENING AND IN-VITRO ANTHELMINTIC ACTIVITY OF METHANOLIC EXTRACT FROM THE STEM BARK OF PLUMERIA RUBRA LINN.
Nature is always being a consistent and constant source of medicinal substances for prevention and cure of various ailments, including the helminth infections, which is one of the health problems that affect human and livestock in the world. Because of limited availability/ accessibility of anthelmintic compounds in modern medicine, and reawakened worldwide interest in plants based medicine, the p...
PHYTOCHEMICAL ANALYSIS AND TOXICITY EVALUATION OF ACETONE, AQUEOUS AND METHANOLIC LEAF EXTRACTS OF AGAPANTHUS PRAECOX WILLD
Agapanthus praecox Willd of the family Amaryllidaceae is widely used in South African traditional medicine to treat heart disease, paralysis, coughs, colds, chest pains and diarrhoea. The decoction is used to prevent pregnancy complications and argument labour. The study aims at determining the phytochemical constituents and investigating the potential toxicity of the solvent extracts of A. praeco...
ABOUT THE CERTAIN TOPOLOGICAL INDICES OF THE LINE GRAPH OF V-PANTACENIC NANOTUBE
A topological index is a numeric quantity associated with a graph which characterizes the topology of the graph and is invariant under graph automorphism. Topological indices such Randić, atom-bond connectivity (ABC) and geometric (GA) indices are used to predict the bioactivity of different chemical compounds. Recently, the edge version of atom-bond connectivity and geometric arithmetic indices ...
OUTCOMES OF COMMUNITY PHARMACIST’ CARDIOVASCULAR RISK INTERVENTION AMONG HIGH RISK RURAL DWELLERS
Community pharmacists are well placed to contribute to reduction of premature deaths from cardiovascular disease by implementing risk assessment and reduction strategies. The objective of this study was to assess outcomes of pharmacist's cardiovascular risk reduction intervention among high risk persons dwelling in a rural community. Cardiovascular risk reduction intervention was carried out among...
CHARACTERIZATION AND HPLC ANALYSIS OF MANNA FROM SOME COTONEASTER SPECIES
Cotoneaster is a plant from Rosaceae family and produces a sugary secretion (manna). Manna is the most important constituent of species of this plant. Manna consists of different types of carbohydrates, and other phytochemicals. Sugar characterization, including reducing sugar was assayed by cupric/sodium carbonate spectrophotometric method. In addition, the composition of individual sugars was al...
CURCUMIN CONSUMPTION AND COGNITIVE FUNCTION IN ELDERLY
Cognitive impairment in elderly is a growing public health concern, and is mainly caused by dementia of various etiologies. Hence, it is important to explore possible measures to mitigate the risk of dementia. Curcumin, active ingredient of turmeric (Curcuma longa) is used in curry and has shown protective effect on cognition. This study aims to explore the association between curcumin consumption...
IN VIVO EVALUATION OF THE ANTICANCER ACTIVITY OF A WATER-IN-GARLIC OIL NANOEMULSION LOADED WITH DOCETAXEL
Docetaxel (Doc) is an antitumor drug used to treat various types of cancers. However, it has certain limitations in clinical use due to its side effects. The major objective of this study was to assess the antitumor activity and cardiotoxicity of the Doc loaded in a nanoemulsion formulated with the garlic oil (Doc-NEGO) in Ehrlich ascites carcinoma (EAC)-bearing mice. One hundred mice were split i...
EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DROSERA SPATULATA
The aim of the present study is to investigate and evaluate analgesic and anti-inflammatory potential of aqueous and methanolic extracts of Drosera spatulata using different models in rats. The aqueous and methanolic extracts of D. spatulata (at the doses of 3, 4, 5, 8 and 10 mg/Kg body weight) investigated for anti-inflammatory and analgesic activities using various experimental models. Analgesic...
COMPARATIVE QUALITY EVALUATION OF SIX BRANDS OF ENTERIC COATED DICLOFENAC SODIUM TABLETS MARKETED IN ADDIS ABABA
Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties. Because of widespread use of this drug, quality control testing should be done for diclofenac marketed products to ensure safety; efficacy; accepted quality; rationality of use to protect public health. Quality of pharmaceuticals has been great concern of WHO. Drug cost needs to be reduce...
EVALUATION OF THE ANTIDEPRESSANT ACTIVITY OF TRIBULUS TERRISTRIS IN DIABETIC DEPRESSION IN RAT MODEL
Tribulus terristris is a well known medicinal plant as anti-inflammatory, antimicrobial and nephroprotective etc. It is a very good drug for urinogenital problems, hepatic problems, oxidative stress etc. The aim of the study is to compare the depression induced by PCPA and STZ treated diabetic depression in mice and which could be restored by the ethanolic exact of fruits of Tribulus terristris ...