Volume 11 (2020) - Issue 3, March
AN OVERVIEW OF BACTERIOPHAGE THERAPY OVER ANTIBIOTICS; AS AN ALTERNATIVE FOR CONTROLLING BACTERIAL INFECTIONS
Bacteriophages are particular infective agents of diverse bacteria. They are separated into different groups according to their life cycle. The lytic phages kill their host cells; this property can be applied for the selective elimination of pathogenic bacteria. The first bacteriophage treatment was described one hundred years ago, and phage therapy had been extensively used until the Second World...
BIOMATERIAL BASED INJECTABLE HYDROGEL FOR CONTROLLED DRUG DELIVERY: A REVIEW
The aim of a pharmaceutical product is to obtain excellent therapeutic and favorable treatment. Controlled drug release coatings have been around for more than 50 years and their performance has increased significantly since the beginning. The main drawbacks of the controlled drug delivery system are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices,...
GREEN CHROMATOGRAPHY: THE ECO-FRIENDLY AND SAFER CONCEPT OF GREEN ANALYTICAL CHEMISTRY
Green analytical chemistry is an attempt to reduce the environmental hazards caused by chemicals and chemical processes. To avoid the use or formation of dangerous materials, the best way is to prevent pollution rather than cleaning up the process. Therefore, it is important to choose a method with the least harmful effects on the environment. The main focus or aim of green chromatography is to ...
AN OVERVIEW OF BACTERIOPHAGE THERAPY OVER ANTIBIOTICS; AS AN ALTERNATIVE FOR CONTROLLING BACTERIAL INFECTIONS
Lung cancer is a malevolent lung growth characterized by unrestrained cell expansion in tissues of the lung. EGFR is occupied dissimilar fundamental presentation of cancer cells that includes expansion of cells, enlargement, propagation, apoptosis regulation etc. make it a prime objective for lung cancer. EGFR is a tyrosine kinase inhibitor that is proposed in epithelial cells. EGFR inhibitors are...
ENHANCEMENT OF POOR ORAL ABSORPTION DRUG VIA LIPID FORMULATION: SELF EMULSIFYING DRUG DELIVERY SYSTEM
The oral route of drug administration is one of the simplest route of drug administration throughout the world because its patients convenience. The drug administered through orally should possess good aqueous solubility for better oral absorption and thus bioavailability will increase. But it was found that 30-40% of the drug shows low solubility thus bioavailability profile will be affected. Sel...
SPANLASTICS: A MODERN APPROACH FOR NANOVESICULAR DRUG DELIVERY SYSTEM
Drug delivery to targeted sites is restricted by various barriers. The conventional drug delivery systems like tablets, capsules, suspensions, emulsions, elixirs, lotions etc. are being encountered with a number of issues such as poor bioavailability, drug shelf life, drug-excipients incompatibilities and patient in compliance. Thus with the advent of novel drug delivery systems such as liposomes;...
A REVIEW ON OBESITY COMPLICATIONS AND ITS MANAGEMENT
The article focuses on the prevalence of obesity in India, increasing levels of childhood obesity, and the potential health hazards that result from obesity, thereby suggesting the necessary preventive measures and the prevailing natural and synthetic therapy that can help to cure the disease, thus spreading awareness about its severity and necessity for treatment. Obesity in India has reached epi...
GASTRORETENTIVE MICROBALLOONS: A NOVEL APPROACH FOR DRUG DELIVERY
Hollow microballoons (microspheres) are spherical empty particles without core. Microballoons (Hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug-delivery systems are based on a non-effervescent system containing empty particles of spherical shape without core ideally having a size less than 200 micrometers. Microballoo...
A REVIEW ON CHROMEN DERIVATIVES AS ANTIEPILEPTICS
Chromens are oxygen-containing heterocycles, abundantly found in nature in the form of flavone, is flavones, flavanones, catechins, anthocyanins and collectively known as flavonoids and isoflavonoids. Being a polar and ionizable aromatic compound, it improves the pharmacokinetic characteristics of lead molecules. Imidazole derivatives have occupied a unique place in the field of medicinal chemistr...
A REVIEW ON IMPAIRMENT IN METABOLIC PATHWAYS DUE TO TYPE 2 DIABETES MELLITUS
Despite years of intensive research, impairment in metabolic pathways due to type 2 diabetes mellitus continues to be a daunting global challenge. It is equally challenging problem in this region as well. In recent years there is growing clinical and experimental evidence that oxidative stress plays an important role in induction and promotion of diabetes and its associated complications. Lipid pe...
IDENTIFICATION OF HEAVY METAL TOXICITY INDUCED BIOMARKERS AND THE PROTECTIVE ROLE OF ASCORBIC ACID SUPPLEMENTATION IN CHANNA PUNCTATUS
Arsenic and mercury are presently the most common pollutants of freshwater bodies. There is a continuous increase in the toxic level of these pollutants with some seasonal changes, affecting the aquatic biota. The present study aimed to identify cellular biomarkers of arsenic and mercury toxicity in freshwater fish Channa punctatus. Antioxidant defense like catalase (CAT), superoxide dismutase (SO...
FABRICATION AND COMPARATIVE EVALUATION OF CURCUMIN AND PACLITAXEL- LOADED SOLID LIPID NANOPARTICLE; THE PATHWAY OF EFFECTIVE CANCER THERAPY
The objective of the present study is to develop, evaluate and compare potent phytoconstituents of curcumin loaded solid lipid nanoparticles (CUR-SLN) and Paclitaxel loaded solid lipid nanoparticles (PTX-SLN) for the treatment of malignancy. Curcumin is an active phenolic compound of Curcuma longa as a promising phytoconstituent has been extensively studied over the past several years. The result ...
STEADY SHEAR AND DYNAMIC SHEAR RHEOLOGICAL PROPERTIES OF CARBOXY-METHYL LOCUST BEAN GUM INFLUENCING EROSION OF THE POLYSACCHARIDE COAT OF COMPRESSION COATED TABLETS
Rheological properties of carboxymethyl locust bean gum (CMLBG) solutions having different concentrations and solution pH were evaluated through steady shear and oscillatory measurements and were used to describe the erosion propensity of CMLBG coat of compression coated placebo tablets. CMLBG solutions, irrespective of concentration and solution pH, exhibited predominant viscous character as the ...
XANTHAN GUM GRAFT COPOLYMER / SODIUM ALGINATE MICRO BEADS COATED WITH CHITOSAN FOR CONTROLLED RELEASE OF CHLORTHALIDONE DRUG
In the present work, temperature/pH-sensitive copolymer beads of chitosan (CS) coated sodium alginate/xanthan gum grafted N, N'-methylenediacrylamide have been synthesized by free radical polymerization in an atmosphere of nitrogen using AIBN/Fe2+ redox pair initiator and Tetramethylethylenediamine (TEMED) as a catalyst followed by simple ionotropic gelation technique. These beads were characteriz...
ANTIBACTERIAL ACTIVITY OF ANDROGRAPHIS PANICULATA OF METHANOLIC EXTRACT AGAINST SOME HUMAN PATHOGENIC BACTERIA AND EFFECT OF ANDROGRAPHOLIDE COMPOUND AGAINST BACTERIAL PATHOGEN
Cold and hot methanolic extract of leaves and whole plant parts of Andrographis paniculata were tested against gram-negative Escherichia coli (MTCC 1679) Klebsiella pneumonia (MTCC 4032) Streptococcus pyogenes, Solmonella typhimurium (MTCC733) and gram-positive Staphylococcus aureus (MTCC737). Maximum activity among all the bacterial cultures tested was showed against E. coli MTCC1679 when compare...
ANTHROPOMETRIC AND BIOCHEMICAL ANALYSIS OF NORMAL AND OBESE SUBJECTS ON AN INDIAN POPULATION
Obesity is a very serious health problem worldwide. Obesity depends on several physical and bio-chemicals parameters that are discussed in this work, i.e., BMI, cholesterol level that includes Total cholesterol (TC), High density lipoprotein concentration (HDL-c), Low density lipoprotein (LDL-c), Triglycerides level (TG), Glucose level, Postprandial glucose level. The present study throws light on...
DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CIPROFLOXACIN AND CURCUMIN IN BULK POWDER
Ciprofloxacin is a class of broad-spectrum fluoroquinolone antibacterial agent and produces a synergistic effect in combination with Curcumin. In the present research work, we have developed a new analytical method for the determination of Ciprofloxacin and Curcumin in its bulk powder. The UV-spectrophotometric method was developed by utilizing a solvent system composed of methanol: water (50:50 v...
EXERCISE-INDUCED OXIDATIVE STRESS MANAGEMENT BY METHANOLIC EXTRACT OF ZINGIBER OFFICINALIS ON SOME VITAL TISSUES IN MALE RAT
Background: Zingiber officinalis known as ginger, under the family Zingiberaceae, is a popular food spice and occupies an important place in Ayurvedic and traditional medicine. Its rhizome is used as antioxidative, carminative and for chronic diseases. Aims: Study indicated the curative effects of methanolic extract of ginger on severe exercise-induced oxidative damage in vital organs. Materials a...
ANTIBACTERIAL EFFICACY OF BIOGENIC COPPER NANOPARTICLES SYNTHESIZED FROM OCIMUM SANCTUM LEAF EXTRACT
A major challenge in treating bacterial infections is the increasing incidence of microbial resistance to antibiotics. This poses a serious threat prompting the search for alternative strategies to treat bacterial infections. Metal nanoparticles as novel antibiotic agents hold promise because they show strong antibacterial activity against various bacterial species, including Gram-positive and Gra...
FORMULATION AND EVALUATION OF COLON TARGETED MICROSPHERES OF GLIPIZIDE
The objective of the present study was to formulate and evaluate microspheres of Glipizide using guar gum and HPMC K4M as polymers for colon-specific delivery for better treatment of Type 2 diabetes. The glipizide microspheres were prepared by ionotropic gelation method by the use of various cross-linking agents. The microspheres were then studied for physical appearance, particle size, surface mo...
STUDIES ON FORMULATION AND EVALUATION OF BILAYERED TABLETS OF CURCUMIN
Bilayer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of the successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The bi-layered tablet is a very different asp...
ASSESSMENT OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF WHEY PROTEIN AND QUANTIFICATION BY REVERSE PHASE HPLC
Dairy and milk consumption are habitually included as important essentials in a healthy and balanced diet. It is the principal food for mammals and provides all the essential energy and nutrients to guarantee proper growth and development. Whey protein present in the milk is quickly digested and therefore amino acids are delivered quickly to muscles to help start the muscle-building process. The m...
COMPARISON OF ANTI-OXIDANT COMPOUNDS AND ANTIOXIDANT ACTIVITY OF NATIVE AND DUAL MODIFIED RICE FLOUR
Rice (Oryza sativa L.) is one of the most important cereal crops consumed in Asia and the primary staple food being consumed by nearly half of the world’s population. Black rice is getting popular recently and is consumed as a functional food. Black rice contains relatively high anthocyanin in the pericarp layer which gives the dark purple color. Black rice has a higher content of phenolic compo...
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE ANALOGUES AS HIV-1 INTEGRASE INHIBITOR
A progression of fourteen narrative quinolonyl diketo acid analogs were planned, synthesized, identified by IR, NMR, CHN and MS supernatural analysis and evaluated as potential HIV-1 Integrase hinders. Compounds of Zinc database were surfed considering Elvitegravir as standard. Nearly 99 compounds were identified and docked in the active site of HIV-1 integrase. Molecular docking study of compound...
99mTc LABELED N-ACETYL NEURAMINIC ACID AS A NEW RADIONUCLIDE PROBE FOR TARGETING CANCER: IN-SILICO AND IN-VITRO STUDY
Radioisotopic imaging based on small molecules like carbohydrate has been regarded as a promising candidate for in-vivo imaging for cancer diagnosis in recent years. In this study, we report that N-acetyl neuraminic acid (Neu5Ac), a type of sialic acid with 9-carbon amino sugar and low pKa value coordinates with the transition radioactive metal 99mTc. The radiochemical yield of 99mTc labeled Neu5A...
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF PARACETAMOL AND CHLORPHENIRAMINE MALEATE
The aim of the present work was to formulate and evaluate Fast Dissolving Tablet (FDT) of a combined oral dosage form of Paracetamol (PCM) and Chlorpheniramine Maleate (CPM). Paracetamol is an antipyretic and Chlorpheniramine maleate is an antihistamine used to relieve symptoms of hay fever, allergy, and the common cold. Combining both the drugs can be used as pain-relieving and fever in cold and ...
MOLECULAR DOCKING STUDY OF NEW-MANNICH BASES DERIVED FROM PYROLLIDINE -2, 5-DIONE AS ANTICONVULSANT AGENTS
To achieve initial conformation of the observed in-vivo antiepileptic activity by utilization of molecular target gamma-aminobutyric acid (GABA) with the help of software i.e., Molegro Virtual Docker ver. 6.0 molecular docking studies were performed. According to the docking studies it was found that the title compounds of series combine and bind precisely with 1OHY subunits of gamma-aminobutyric ...
IDENTIFICATION AND BIOACTIVE POTENTIAL OF ENDOPHYTIC FUNGI FROM MARINE WEEDS AVAILABLE IN THE COASTAL AREA OF BANGLADESH
Endophyte is a rich source of bioactive metabolites for medicinal exploitation as an increasing number of novel compounds with bioactive potential are now being isolated from this source. This study was conducted to characterize and explore endophytic fungi from marine weeds available in Bangladesh. The whole weed was used for isolation of endophytic fungi in the water agar media and the isolated ...
CASE REPORT OF RELAPSE ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) -A DIAGNOSTIC DILEMMA
Acute lymphoblastic leukaemia (ALL) of the B-cell lineage (B-ALL) is a malignant neoplasm identified by the accumulation of immature lymphoid progenitor cells in bone marrow and blood. Numerous chromosomal aberrations have been found to be correlated with disease, relapse and its clinical outcome. The survival and cure rate has been improved drastically with the advent of modern methods of diagnos...
FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY OF HYDRALAZINE HYDROCHLORIDE FOR THE TREATMENT OF HYPERTENSION
In the present study novel matrix diffusion controlled transdermal patches of Hydralazine hydrochloride, a hypertensive drug to ensure satisfactory drug release were successfully prepared by solvent casting method with optimization of suitable polymeric blend of Eudragit L100 (EL-100), ethyl cellulose (EC), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), carbopol, hydroxypropyl cellulose (HPC...
A MODIFIED EFFICIENT METHOD FOR ISOLATION OF RHEIN FROM CASSIA ANGUSTIFOLIA (SENNA)
Chemically, rhein is 9, 10-Dihydro-4, 5-dihydroxy-9, 10-dioxo-2-anthracenecarboxylic acid, and use as an intermediate to synthesize diacerein which widely used in the treatment of degenerative diseases like, osteoarthritis, osteoporosis, and rheumatoid arthritis and hence has commercial importance. Rhein occurs in free state in nature in different plant families like Cassia, Rhamnus, and Rheum but...
STEADY SHEAR AND DYNAMIC SHEAR RHEOLOGICAL PROPERTIES OF CARBOXYMETHYL LOCUST BEAN GUM INFLUENCING EROSION OF THE POLYSACCHARIDE COAT OF COMPRESSION COATED TABLETS
Pulsatile drug delivery is one such system thereby delivering drug at the right time, right place and in right amounts and holds good promises and provides benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc. The present study investigated that optimization of quinapril hydrochloride was successfully done and batch A8 was given satisfactory results. Ta...
DEVELOPMENT AND VALIDATION OF GAS CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF GENOTOXIC IMPURITY, EPICHLOROHYDRIN, IN LINEZOLID DRUG
A sensitive and robust gas chromatography with a flame ionization detector method was developed for the quantification of epichlorohydrin in the linezolid drug substance and validated using guidelines as mentioned in ICH Q2 (R1). Epichlorohydrin was separated on CP-Volamine stationary phase (length 60 m, diameter 0.32 mm, particle size 5 µ) in linear thermal programming using dichloromethane as a...
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF LEAF EXTRACT PREPARED BY SOXHLET EXTRACTION OF SELECTED MEMBERS OF APOCYNACEAE
The present study aimed to understand, phytochemistry and antioxidant property of five members belonging to Apocynaceae, Catharanthus roseus (L) G. Don; Plumeria alba L.; Pentalinon luteum (L) B. F. Hanson & Wunderlin; Rauvolfia tetraphylla L and Nerium oleander L. The preliminary phytochemical analysis was carried out using the methanolic extract for protein, carbohydrate, alkaloids, phenol, ...
LARVICIDAL ACTIVITY OF EPALTES PYGMAEA (DC) WHOLE PLANT EXTRACTS AGAINST CULEX QUINQUEFASCIATUS SAY, AEDES AEGYPTI L. AND ANOPHELES STEPHENSI LISTON LARVAE
In the present study, the larvicidal activity of successive n-hexane, chloroform, ethyl acetate and ethanol extracts of Epaltes pygmaea DC (Family: Asteraceae) whole plant was carried out against three mosquito species namely Culex quinquefasciatus, Aedes aegypti L. and Anopheles stephensi. The crude whole plant was successively extracted with n-hexane, chloroform, ethyl acetate, and ethanol. The ...
DEVELOPMENT OF A LIQUID ORAL IN-SITU GEL OF VORICONAZOLE FOR SUSTAINED RELEASE AND ENHANCED BIOAVAILABILITY: EQUIVALENCE TESTING USING EARTH MOVER’S DISTANCE
Development of a sustained release liquid oral in-situ gel of Voriconazole with improved bioavailability has been the main aim of this project. Complexation of the drug with hydroxypropyl beta-cyclodextrin was done to improve the solubility and stability of the drug. The mucoadhesive polymer carbopol 934P and release retardant HPMC E50 were used as factors and a two-square factorial design was emp...
FORMULATION AND CHARACTERIZATION OF SILVER NANOPARTICLE COATED WITH NATURAL pH STIMULI POLYMER
Carboplatin is the first-line choice of drug for ovarian cancer. In this investigation, we have prepared carboplatin silver nanoparticles (CSNP’s) by electrostatic adsorption. The size range was found to be 53-87 nm and the zeta potential was in the range of -36 to -61. After coating with hyaluronic acid and drug the size was observed to be around 80 nm and zeta potential was -41. After coating ...
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF BILASTINE AND ITS IMPURITIES BY UPLC METHOD
This study describes the development and validation of stability indicating UPLC method for Bilastine and its impurities, an anti-allergic drug. Bilastine was subjected to stress degradation under different conditions recommended by the International Conference on Harmonization to observe the degradation products. The successful separation of Bilastine from its synthetic impurities and degradation...
EVALUATION OF COLOUR FASTNESS PROPERTIES OF MICROBIAL PIGMENT EXTRACT FROM NOVEL SOURCES FOR TEXTILE ECOFRIENDLY DYEING & STUDY OF CIE LAB COLOUR VALUE
The pigment has acquired the greatest importance because of its excellent color value. The potential use of various carbon sources as microbial pigments for textile coloration. Flowers, leaves, fruits, vegetables, and tubers are the rich source of the secondary metabolites. In the current study, the use of microbial extract isolated from a fermentation process from 14 varieties by using Penicilliu...
SPECTRUM OF INFECTIONS AND ASSESSMENT OF ANTIBIOTIC USE IN MAINTENANCE HEMODIALYSIS PATIENTS
Indian literature relating to the spectrum of infections in maintenance hemodialysis patients has not been extensively published. The purpose of this study was to carry out surveillance of infections in this population and to determine the clinical patterns and outcomes of infections and also to assess the prescribed antibiotic therapy. This was a prospective observational study carried out in the...
EVALUATION OF PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF EPIPHYTIC ORCHID LUISIA ZEYLANICA LINDL.
The present study was carried out to evaluate phytochemical composition and pharmacological activities of leaf extract of Lusia zeylanica by using different solvents. The solvents like n-hexane, ethyl acetate and methanolic were used to extract dried leaf material of L. zeylanica. These extracts were analyzed for phytochemical constituents with GC-MS analysis and antimicrobial activity tested agai...
GREEN APPROACH ON ACHIEVING ZINC OXIDE NANOPARTICLES AND ITS POTENTIAL BACTERICIDAL AS WELL AS ANTIOXIDANT ACTIVITY
Biosynthesis of nanoparticles by biological means especially plant extract plays a major role in the field of nanotechnology. In the present study, the aqueous extract of lemon peel (Citrus limon) was used for the green synthesis of ZnO nanoparticles using 0.1 M Zn(NO3)2 as a precursor in alkaline condition using NaOH with vigorous stirring for 3 h. ZnO NPs obtained were characterized by UV-vis sp...
ANTI-INFLAMMATORY, IN-SILICO DOCKING AND ADME ANALYSIS OF SOME ISOLATED COMPOUNDS OF TAGETES ERECTA FLOWER HEADS
Inflammation is a normal, protective response to tissue injury caused by physical trauma, noxious chemicals or microbiological agents. Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as complementary medicine. In the present study methanolic extract of flower heads of Tagetes erecta was screened for its phytochemical constituents and then subjec...
EFFECT OF INDUCTION CHEMOTHERAPY ON VITAMIN D LEVEL IN CHILDREN WITH ACUTE LEUKEMIA
Background: Subnormal level of vitamin D are associated with the higher frequency of cancer and correlated with inferior prognosis in some cancers; no data exist for acute leukemia. Aim of the work: To clarify the relationship between serum vitamin D levels and acute leukemia in children. Materials and Methods: Vitamin D level was measured in sixty-six pediatric patients who are newly diagnosed wi...
PREPARATION, OPTIMIZATION AND CHARACTERIZATION OF LETROZOLE NANOLIPOSOMES
Objective: Nanoliposomes of letrozole a drug used for breast cancer treatment were formulated. The present investigation was aimed to optimize the phospholipids concentration by formulating a series of nanoliposomes formulation and their characterization. Methods: Nanoliposomes were prepared using reverse-phase evaporation technique employing diverse ratios of soya lecithin and cholesterol concent...
FORMULATION AND EVALUATION OF DERMA HEAL CREAM AGAINST WOUND AND BURN HEALING ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR ALBINO RAT
Delayed wound healing is producing a high economic burden on the society and is generally associated with Diabetes mellitus or a related complication thus needs safe treatment like herbal formulation. Dermas heal cream (an anti-diabetic ayurvedic formulation) was evaluated for wound and burn healing potential in normal and diabetic rats. The effect of Derma heal cream on wound healing has been stu...
SALUTARY ACTIVITY OF BERBERINE AGAINST DIBUTYLTIN DICHLORIDE INDUCED ACUTE PANCREATITIS IN ALBINO WISTAR RATS
Background: Berberine is a natural alkaloid used as traditional Chinese medicine. Objective: The objective of the present study was to evaluate the effect of berberine on dibutyltin dichloride (DBTC) induced acute pancreatitis in albino Wistar rats. Methods: In this study 24 Wistar rats were randomly selected and divided into four groups. Each group consists of 6 animals. Group-1 (-ve control), Gr...
FORMULATION AND EVALUATION OF QUERCETIN LOADED CHITOSAN-HYDROXY-APATITE BIO COMPOSITE MICROSPHERES FOR PERIODONTITIS
Periodontitis is a group of inflammatory pathological conditions involving periodontal ligaments and supporting alveolar bone which may result in the degeneration of supporting structures of teeth ultimately leading to tooth loss. Present research work is focused on the formulation, optimization and evaluation of chitosan microspheres and chitosan- hydroxyapatite biocomposite microspheres to have ...
DRUG UTILIZATION STUDY OF ANTIHYPERTENSIVE TREATMENT BEING PRESCRIBED IN PATIENTS COMING TO MEDICINE OPD OF A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 ...
CONCOMITANT INFLUENCE OF HEAVY METAL INTOXICATION ON SIZE OF ORGANS AND BODY WEIGHT IN ALBINO RATS
Being exposed to a number of heavy metals in the environment, humans are suffering from various health problems. Cadmium and arsenic are both priority hazardous substances and carcinogens. Environmental co-exposure to these heavy metals is also an important consideration and most experiments with laboratory animals investigate only one heavy metal. In the present study albino rats were exposed to ...
CANAGLIFLOZIN SILICA LIPID HYBRID PARTICLES FOR IMPROVED SOLUBILITY AND DISSOLUTION
Silica lipid-hybrid formulations have gained an increased interest in recent times as a means to enhance the solubility as well as dissolution of poorly water-soluble lipophilic drugs. The objective of the present investigation was to design and optimize silica lipid hybrid particles of Canagliflozin to improve its solubility. Canagliflozin is an antidiabetic drug used to improve glycaemic control...
CARDIOPROTECTIVE EFFECT OF ARBUTIN ON LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE SYSTEM IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS
The present study was designed to investigate the cardioprotective effect of Arbutin (ARB) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac and hepatic markers, antioxidant defense system, lipid peroxidation products and histopathological changes. Rats were pretreated with ARB (25 and 50 mg/kg BW) for 21 days. After pretreatment, ISO (60 mg/kg BW) was admi...
HAEMOTOXICITY OF LEAD (Pb) ON THE BLOOD PARAMETERS OF FRESH WATER TELEOST HETEROPNEUSTES FOSSILIS (BLOCH)
Blood parameters are important indicators for assessing the health status of living organisms subject to changing environment. Blood parameters (Hb%, TEC, TLC, ESR, PCV, MCH, and MCV) of Heteropneustes fossilis exposed to lead were investigated at different time intervals. Acclimatized specimens were divided into four groups: Group-A (Control), Group-B (2.25 ppm), Group-C (2.65 ppm), Group-D (2.85...
STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF EMITRICITABINE, TENOFOVIR, COBICISTAT AND ELVITEGRAVIR
A stability-indicating RP-HPLC method for the simultaneous determination of emtricitabine (EMT), tenofovir (TNF), cobicistat (COB) and elvitegravir (ELV) in solid dosage forms. The waters 2695, High-Performance Liquid Chromatographic system with column kromasil C18, 250 × 4.6 mm, 5 µ. The detector used is PDA detector at 288 nm. The mobile phase used in this method is pH-3.5 phosphate buffer and...
DESIGN, DEVELOPMENT AND EVALUATION OF TOPICAL ANTIINFLAMATORY HERBAL GEL
The objective of the present investigation was to develop topical curcuminoids containing gel as an anti-inflammatory. The first gel base was prepared by using various different concentrations of Carbopol 934, Propylene glycol 400, Methylparaben, Propylparaben, and required amount of distilled water. The optimized base was selected for the incorporation of different concentrations of curcuminoids ...
NOVEL SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF CURCUMIN AND DICLOFENAC DIETHYLAMINE IN DEVELOPED DOSAGE FORM
Rheumatoid arthritis is an autoimmune disease that involves inflammation of joints. Diclofenac diethylamine, as well as Curcumin, are widely used for symptomatic relief of pain and inflammation. The present study was aimed at providing a simple, accurate and economical spectrophotometric method for simultaneous determination of curcumin and diclofenac diethylamine from topical gel formulation. Sim...
FORMULATION AND EVALUATION OF STOMACH SPECIFIC FLOATING IN-SITU GEL OF CLARITHROMYCIN
Floating drug delivery system comes with the advantage of sustained release of drugs over a prolonged period of time thereby maximizing the oral absorption of drugs with narrow absorption window, it overcomes the challenges of conventional oral drug delivery system. The aim of the present work was to develop a novel floating in-situ gelling system for sustained drug delivery of Clarithromycin for ...
ASSESSMENT OF FIXED DOSE COMBINATIONS IN A TERTIARY CARE TEACHING HOSPITAL
Fixed-dose combinations are defined as a combination of two or more active ingredients in a fixed ratio of doses. Recently fixed-dose combinations are more rapidly marketed; the available combinations in the market include both rational and irrational. The use of irrational fixed-dose combinations has resulted in severe adverse drug reactions and a reduction in patient quality of life. The main ob...
SCREENING OF PHYTOCHEMICALS, FATTY ACID COMPOSITION AND IN-VITRO ANALYSIS OF ANTIOXIDANT PROPERTY OF GREEN EDIBLE SEAWEED CAULERPA LENTILLIFERA (FAMILY: CAULERPACEAE)
Marine algae are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against the other settling organisms. These seaweeds are an immense source of bioactive molecules for the exploration of novel drugs. The present investigation deals with the screening of ...