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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 3 (2012) - Issue 7, July

Review Articles

 
Title
Views
PDF
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1.

SUPERCRITICAL FLUID TECHNOLOGY: NASCENT CONTRIVANCE FOR PHARMACEUTICAL PRODUCT DEVELOPMENT

A supercritical fluid (SF) can be defined as a dense non condensable fluid. A fluid reaches the supercritical status when its temperature and pressure exceed the relevant critical temperature and pressure. At the critical point only a single phase exists which has some properties typical of liquids (density) and some of gases (viscosity, compressibility, and mass diffusion coefficient). For pharma...

B.S. Wakure*, A.V. Yadav , N.M. Bhatia and M.A. Salunke

Vilasrao Deshmukh Foundation, Group of Institutions, VDF School of Pharmacy , Latur-413 531, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1872-82

1872-1882

1619

583

2.

CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW. PART 1- CRINUM ALKALOIDS: LYCORINE-TYPE ALKALOIDS

Crinum is an important Amaryllidaceous plant thanks to the valuable biological and therapeutic activities of its chemical constituents, especially alkaloids. Many Crinum species have been commonly used in traditional medicines worldwide. Long ago, they have been subjected to extensive chemical, cytological and pharmacological investigations. Accordingly, this work comprehensively comprises both th...

John Refaat*, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

Pharmacognosy Department, Faculty of Pharmacy, Minia University , 61519 Minia, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1883-90

1883-1890

1999

1255

3.

IN-SITU OPHTHALMIC GELS FOR THE TREATMENT OF EYE DISEASES

Topical administration of a drug in the conjunctival cul-de-sac is the treatment of choice for diseases of the anterior segment of eye. Development of ophthalmic drug delivery systems has always been challenging because of the drawbacks with this route, like non-productive absorption, drainage, induced lacrimation, tear turn over, impermeability of drugs to cornea. New approaches have been investi...

M. Jothi, S.L. Harikumar* and Geeta Aggarwal

Rayat & Bahra Institute of Pharmacy, Sahauran, Kharar, Mohali-140104, Panjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1891-04

1891-1904

3271

944

4.

AN INSIGHT INTO OCULAR INSERT

Ocular inserts are sterile preparations, with a thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into cul-de-sac or conjunctiva sac. They are usually made up of polymeric vehicle containing drug. Ocular drug delivery is one of the most fascinating and challenging tasks being faced by the Pharmaceutical researchers. One of the major barriers of ocular medication i...

Shweta Kaul*, G. Kumar and P. Kothiyal

Division of Pharmaceutical Sciences, S.G.R.R.I.T.S., Patel Nagar, Dehradun-248 001, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1905-12

1905-1912

1974

512

5.

CHALCONE AS A VERSATILE MOIETY FOR DIVERSE PHARMACOLOGICAL ACTIVITIES

Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of chalcones. These are considered to be precursors of flavonoids and isoflavonoids. The aim...

Hatish Prashar*, Anshul Chawla, Anil Kumar Sharma and Rajeev Kharb

CT Institute of Pharmaceutical Sciences, Jalandhar, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1913-27

1913-1927

2298

1817

6.

APPROPRIATE USE OF ANTIBIOTICS FOR THE MANAGEMENT OF SEPSIS IN NEONATES

Neonatal sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolongation of hospital stay. Clinical features of sepsis are non-specific in neonates and a high index of suspicion is required for timely diagnosis. Antibiotics are a very important group of drugs for the sick neonate and have undoubtedly played a role in their improved survival. But...

Samiya Nazeer Khan* and Siby Joseph

Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences, Kochi, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1928-34

1928-1934

1500

566

7.

POSSIBLE LINKS BETWEEN OBESITY AND TYPE 2 DIABETES MELLITUS

In this article, an attempt has been made to explore a positive correlation between obesity and type 2 diabetes mellitus. The possible role of several important agents in causing both has been discussed in detail. From the discussion, it seems that obesity is definitely and intimately linked to type 2 diabetes....

C.K. Chakraborti

K. M. Institute of Pharmaceutical Sciences, Rourkela- 769 015, Orissa, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1935-45

1935-1945

1348

686

8.

APOPTOSIS SIGNALING; A DRUG DESIGN IN CANCER THERAPY: A REVIEW

Apoptosis plays an important role in development, growth, differentiation, altered gravity conditions, tissue homeostasis, immune defense, and cancer to control cell number in tissues and to eliminate individual cells that threaten the animal’s survival. The purposes of this review are to describe the signaling pathways and the cellular changes that occur with apoptosis. Currently, two pathways ...

Md. Ataur Rahman*

Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chuncheon, Gangwon-do, 200-702, South Korea

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1946-54

1946-1954

1175

414

9.

A BRIEF VIEW ON ANTIHYPERTENSIVE DRUGS DELIVERY THROUGH TRANSDERMAL PATCHES

Transdermal Drug Delivery System (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through skin in a predetermined and controlled rate. Hypertension  is  one  of  the  common  disorder   for  the  mankind. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. The ...

V. Rastogi*, Pragya, P. Upadhyay

Department of Pharmacy, IFTM University, Moradabad- 244 001, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1955-70

1955-1970

4135

1499

10.

ROLE OF ANTIOXIDANTS IN ORAL MEDICINE

The realization that reactive oxygen species and oxidative stress play an important role in the etiology and progression of major human degenerative diseases has triggered enormous and worldwide interest in endogenous and exogenous antioxidants. The 1990’s have seen the explosion of interest in antioxidants. The article reviews free radical chemistry, antioxidant systems & their role in huma...

Sumit Bhateja

Department of Oral Medicine Diagnosis & Radiology, Dr. DY Patil Dental College & Hospital, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1971-75

1971-1975

2911

934

11.

RECENT TECHNIQUES OF PHARMACEUTICAL SOLVENTLESS COATING: A REVIEW

The  coating  of  solid  pharmaceutical  dosage  forms  began  in  the  9th  century  B. C.,  with the  Egyptians.  Conventional coating techniques are based on solvents or water. Solventless coatings are alternative technique of coating. In  solventless  coating,  the coating  material  is  directly  spread  on  the  core  and  then  it  is  cured  by  special  me...

Shital Dhuppe , S.S. Mitkare*, D.M. Sakarkar

Assistant Professor, School of Pharmacy, S. R. T. M. University, Nanded-431 606, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1976-86

1976-1986

2020

1229

12.

TURMERIC: THE GOLDEN SPICE OF LIFE

Turmeric is an ancient spice derived from the rhizomes of Curcuma longa, which is a member of the ginger family (Zingiberaceae). Also known as ‘Golden Spice of India’ turmeric has been used in India for medicinal purposes for centuries. It has been used in traditional medicine as a household remedy for various diseases, including biliary disorders, anorexia, cough, diabetic wounds, hepatic dis...

Preeti Rathaur*, Waseem Raja, P.W. Ramteke and Suchit A. JohnDepartment of Biological Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad- 211007, Uttar Pradesh, India

Department of Biological Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad- 211007, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1987-94

1987-1994

4365

1336

13.

A REVIEW ON ACACIA ARABICA – AN INDIAN MEDICINAL PLANT

The use of herbal drugs for the prevention and treatment of various health ailments has been in practice from time immemorial. Acacia arabica has been reported to be effective against a variety of disease including diabetes, skin disease and most concerning with cancer. The fresh plants parts of Acacia arabica is considered as astringent, demulcent,  aphrodisiac, anthelmintic, antimicrobial, anti...

Saurabh Rajvaidhya*, B.P. Nagori, G.K. Singh, B.K. Dubey, Prashant Desai, S. Alok and Sanjay Jain

T.I.T. College of Pharmacy, Bhopal, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1995-05

1995-2005

30281

4148

14.

BIOLOGICAL NANOROBOT ARCHITECTURE FOR MEDICAL TARGET IDENTIFICATION

This work has an innovative approach for the development of biological nanorobots with sensors for medicine. The biological nanorobots operate in a virtual environment based on random, thermal and chemical control techniques. The biological nanorobot architecture model has biological nano bioelectronics as the basis for manufacturing integrated system devices with embedded biological nano biosenso...

S. Paul and Dipti*

Department of Computer Science Engineering, Birla Institute of Technology, Mesra, Ranchi -835 215, Jharkhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2006-10

2006-2010

2608

498

Research Articles

 
Title
Views
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Cited
15.

ANTIOXIDANT PROSPECTIVE AND SECONDARY METABOLITES IN ABUTILON INDICUM AT DIFFERENT ENVIRONMENT

To investigate the antioxidant property and secondary metabolites of Abutilon indicum Plant at various Habitats were compared with those of relevant callus cultures induced from every explant in in-vitro. The callus cultures were effectively initiated on Murashige and Skoog (MS) medium supplemented with 2, 4-D (1 mg/L) pooled with different concentrations (0.1–1.0 mg/L) of kinetin as plant growt...

Kandasamy Selvam*, Srinivasan Arunprakash , Thangasamy Selvankumar , Muthusamy Govarthanan and Arumugam Sengottaiyan

Department of Biotechnology, Mahendra Arts & Science College, Kalippatti-637 501, Tamilnadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2011-17

2011-2017

1674

607

16.

ANALGESIC, PHYTOCHEMICAL AND ACUTE TOXICITY EVALUATION OF THE METHANOL EXTRACT OF THE LEAVES OF PTEROCARPUS SANTALINOIDES- FAMILY FABACEA

Pterocarpus santalinoides, family- Fabaceae was claimed to have analgesic properties. The people of Ogidi in Idemili North Local Government Area of Anambra State, Nigeria used it in the management of aches and pains. This study is therefore aimed at determining this claim of the activities of Pterocarpus santalinoides using the leaves which will serve as a criterion to recommend the ethno pharmaco...

C.F. Anowi*, B.O. Umeokoli , A.F. Onyegbule , C. Okonkwo and I. Chibeze

Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, PMB 5025 Awka

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2018-23

2018-2023

1483

771

17.

SPHERICAL CRYSTALLIZATION OF ZALTOPROFEN FOR ENHANCEMENT OF MICROMERITIC PROPERTIES AND DISSOLUTION RATE

The present work deals with the spherical crystallization process by Spherical agglomeration method applied to Zaltoprofen, a novel NSAID drug. The object of present study was to prepare and characterize the spherical agglomeration of water insoluble non-steroidal anti-inflammatory drug. Zaltoprofen spherical agglomerates prepared with poly ethylene glycol, which is hydrophilic polymer by using si...

E. Hari Krishna*, V. Ram Mohan Gupta and S. Jyothi

HOD, Dept. of Pharmaceutics, Shadan College of Pharmacy, Peerancheru, Hyderabad-08, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2024-30

2024-2030

1605

720

18.

ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECT OF ARECA CATECHU

Context: The present investigation provides proof for the effectiveness of Arecanut extract as an anti-inflammatory agent. Arecanut extract is a natural plant product mimic of peroxidase. Objective: To explore the Anti-inflammatory activity of aqueous extract of Areca catechu L in carrageenan, dextran and formalin induced inflammation models in Swiss albino mice, by injection into the interdigi...

Reena Rosy Nelson Anthikat* and A. Michael

Department of Microbiology, PSG College of Arts & Science, Civil Aerodrome P.O., Coimbatore- 641 014, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2031-37

2031-2037

1680

448

19.

ANTIBACTERIAL ACTIVITY OF SOME SELECTED INDIAN MEDICINAL PLANTS

There is a continuous and urgent need to discover new antimicrobial compounds with diverse chemical structures and novel mechanisms of action because there has been an alarming increase in the incidence of new and re-emerging infectious diseases. In recent years, drug resistance to human pathogenic bacteria has been commonly reported from all over the world. In the present scenario of emergence of...

B. Nitha, A.B. Remashree* and Indira Balachandran

Centre for Medicinal Plants Research, Arya Vaidya Sala, Kottakkal, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2038-42

2038-2042

2130

519

20.

IRON OVERLOAD AND GROWTH OF THALASSEMIC PATIENTS IN MARWAR REGION

Growth disturbances are a major clinical feature of thalassemic patients. Regular blood transfusions and iron-chelation therapy greatly contribute to the quality and longevity of thalassemic patients. The main objective of present study was to compare the current growth of Thalassemia major patients, taking into accounts the iron overload, transfusion and iron chelation therapy, therefore we plann...

Bhavana Singhal , Neha Shama* and Ranjana Mathur

Department of Biochemistry, S.R.M.S.I.M.S., Bs-243202,Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2043-49

2043-2049

1410

468

21.

IN-SILICO ANALYSIS AND HOMOLOGY MODELING OF TARGET PROTEINS FOR CLOSTRIDIUM BOTULINUM

The completion of genome sequences of pathogenic bacteria and the completion of human genome project has provided lot amount of data that can be utilized to design vaccines and drug targets. Recently adopting strategies for drug designing is based on comparative genomics approach, it gives a set of genes that are likely to be essential to the pathogen but absent in the host. By performing homology...

Chirag Prajapati*and Chintan Bhagat

Assistant Professor, Department of Computer Science, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat-395007, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2050-56

2050-2056

1490

415

22.

ANTIHYPERTENSIVE MEDICATION PRESCRIBING PATTERNS IN A UNIVERSITY TEACHING HOSPITAL IN SOUTH DELHI

ABSTRACT Study objective: To investigate the use of antihypertensive drugs in hypertensive patients and to identify whether such pattern of prescription is appropriate in accordance with international guidelines for management of hypertension. Methods: This was a prospective analysis. A prescription based survey among patients with established hypertension was conducted at the Me...

Fowad Khurshid *, Mohammed Aqil, Mohammad Shamshir Alam, Prem Kapur and Krishna K. Pillai

Pharmacoeconomics and Outcomes Research Unit; Department of Clinical Pharmacy, College of Pharmacy, King Saud University , P.O Box: 2457, Riyadh-11451, Saudi Arabia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2057-63

2057-2063

2183

597

23.

PHYSICOCHEMICAL CHARACTERIZATION AND QUANTIFICATION OF TOTAL ANTHRAQUINONES OF VISMIA GUIANENSIS (AUBL.) CHOISY

Vismia guianensis is a plant species of high occurrence in the Amazon and northeastern Brazil, which has been studied lately, because of its antimicrobial and anticancer properties.In order to make an herbal medicine, National Agency for Sanitary Surveillance of Brazil, recommends the production of a drug and plant extracts analysis report indicating: method, specifications and results obtained. T...

Sarah Regina Pereira Camelo , Russany Silva da Costa , Flavio Vasconcelos , Francisco Martins Teixeira , Roseane Maria Ribeiro-Costa , Wagner Luiz Ramos Barbosa and Jose Otavio Silva Junior Race*

Laboratory of Pharmaceutical Research and Development, College of Pharmacy, Institute of Health Sciences, Federal University of Pará, University City “José da Silveira Netto”, CEP 66075-110, Belém, Pará, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2064-70

2064-2070

1898

411

24.

IN-VITRO ANTIOXIDANT AND PHYTOCHEMICAL SCREENING OF ETHANOLIC EXTRACT OF ALPINIA PURPURATA

Plants containing bioactive substances have increasingly become the object of research studies, opening alternative paths for therapeutic treatments or revealing substances that could later be explored and synthesized to produce pharmaceutical, cosmetic and agrochemical formulations. Alpinia purpurata have strong effect on H2O2 induced oxidative damages. The extract of Alpinia purpurata showed a h...

Justi Jovitta. C*, Sreenivasan Aswathi and S. Suja

Department of Biochemistry, Dr. N.G.P Arts and Science College, Kalapatti road, Coimbatore-641 048, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2071-74

2071-2074

1830

800

25.

PHARMACOGNOSTICAL PROFILE OF PAEDERIA FOETIDA LINN. LEAVES

The leaves of Paederia foetida Linn. (P. foetida) are commonly known as skunk vine or Chinese fever vine, are used for various ailments medicinally throughout Asia and other tropical parts of the world by traditional healers.  The plant is mainly used for arthritis and rheumatic disorders. The whole plant shows tonic, astringent and antiphlogistic actions and has been used in tenesmus. This prese...

Sandeep Shetti , Dinesh Kumar Chellappan*, Indra Prakash Sharma and Anandarajagopal Kalusalingam

M. Pharm., Ph.D., Lecturer, Department of Life Sciences, School of Pharmacy and Health Sciences, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2075-81

2075-2081

1636

521

26.

INFLUENCE OF RIPENING ON ANTIOXIDANT ACTIVITY OF CELL WALL POLYSACCHARIDES IN PRUNUS ARMANIACA LINN.

Cell wall polysaccharides have been of great importance to society and mankind over the years. In the present study Cell wall polysaccharides were extracted from different stages viz- Immature green, mature green and ripe stages of Prunus armaniaca Linn. A decrease in the yield of pectin was observed during ripening.The pectin Extracted from various stages of fruit ripening was further analysed fo...

Aprajita Bhardwaj*, Naveen Singhal , Satish Verma , Somya Srivastava and Kiran Tripathi

Lecturer, Department of Biochemistry, Sai Institute of Paramedical & Allied Sciences, Woodland House, Subhashnagar chowk, Mohabbewala, Dehradun- 248 001, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2082-85

2082-2085

1303

680

27.

SIMULTANEOUS QUANTIFICATION OF RUTIN AND ISOQUERCITRIN FROM JASMINUM SAMBAC AIT., BY HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY

A normal phase high performance thin layer chromatography (HPTLC) method has been developed and validated for simultaneous quantitative determination of two flavonoids viz. rutin and isoquercitrin from dried leaf powder of Jasminum sambac Ait.  The analysis was performed on TLC aluminum plates precoated with silica gel 60F254. Linear ascending development was carried out in a twin-trough glass ch...

IJPSRV. Dighe and D. Mestry*

Chemistry Department, Ramnarain Ruia College, Matunga, Mumbai- 400 019, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2086-92

2086-2092

1564

736

28.

SEARCH FOR ANTIMICROBIAL POTENTIALS FROM SIMMONDSIA CHINENSIS

Seeds of Simmondsia chinensis were extracted with pet ether, benzene, chloroform, ethyl acetate, methanol and distilled water for evaluating its antimicrobial activity and phytochemical analysis. The purpose of screening is to justify, authenticate the use of Indian Medicinal plants in ethnomedicinal or folklore as traditional treasure to cure various ailments. In present investigations attempts w...

Ekta Menghani* Shakera Khan and Mohit Soni

Associate Professor, Mahatma Gandhi Institute of Applied Sciences, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2093-97

2093-2097

1264

434

29.

SOLUBILITY ENHANCEMENT OF CANDESARTAN CILEXETIL BY SELF EMULSIFYING DRUG DELIVERY SYSTEMS

The present research work was aimed at the enhancement of solubility of Candesartan by Self Emulsifying Drug Delivery Systems (SEDDS). Candesartan is a BCS class II drug having low aqueous solubility and high permeability; hence its bioavailability is solubility rate limited. The saturated solubility of Candesartan in various oils and surfactants was determined. The excipients were screened and se...

M. Sunitha Reddy*, P. Srinivas Goud and S.S. Apte

Center for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2098-04

2098-2104

2086

922

30.

CHRONIC TOXICITY STUDIES OF PLUMERIA ACUMINATA AND GALEGA PURPUREA IN EXPERIMENTAL ANIMALS

The use of medicinal plants and preparations derived from them as dietary supplements, nutraceuticals, functional foods and herbal medicinal products has become more widely accepted in developing countries. Therefore, it is important to evaluate the adverse effects of these plants and their preparations. The objective of this study was to evaluate the safety of the methanol extracts Plumeria acumi...

Periyasamy Gomathi*, Malaya Gupta and Upal Kanti Mazumder 2

M. Pharm., Ph. D, Associate Professor, Vaagdevi College of Pharmacy, Kishanpura, Hanumkonda, Warangal- 506 001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2105-12

2105-2112

1850

585

31.

ANTIMICROBIAL ACTIVITY OF ETHANOL AND AQUEOUS EXTRACTS OF PARINARI CURATELLIFOLIA (STEM) ON DENTAL CARIES CAUSING MICROBES

Antimicrobial activity of ethanol and aqueous extracts of Parinari curatellifolia (stem) were tested against five dental carries causing bacteria and three fungi strains by agar diffusion method. The crude extracts showed a broad spectrum of antibacterial activity inhibiting the five strains of bacteria and the three fungi. The extracts were most effective against Aspergilusflavus, followed by Str...

E.O. Oshomoh and M. Idu*

Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Benin, Benin city, Edo State, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2113-18

2113-2118

1457

390

32.

INCIDENCE OF POLYPHARMACY INDUCED DRUG INTERACTION IN A TERTIARY CARE HOSPITAL

Drug interaction represents a major problem in day- to- day practice. The incidence of adverse reactions increases almost exponentially as the number of drugs co prescribed rises, and this is in part due to interaction. Critically ill, chronically ill and elderly patients are particularly at risk of drug interactions due to polypharmacy as well as impaired homeostatic mechanisms. The study was aim...

Nimmy N. John*, R.H. Udupi and K.M. Binu

Department of Pharmacy Practice, N.E.T. Pharmacy College, Raichur, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2119-21

2119-2121

1388

418

33.

EFFECT OF DIFFERENT EXTRACTS OF STEM BARK OF FICUS SP. ON MULTIDRUG RESISTANT PATHOGENIC BACTERIA

Medicinal plants represent a rich source of antimicrobial agents. The traditional medicine involves the use of different plant extracts of bioactive constituents. Ficus is a huge tropical deciduous or evergreen tree with more than 800 species. Purpose:  Ficus benghalensis, Ficus religiosa, Ficus recemosa are important ingredients in many siddha, ayurveda and traditional formulations and used f...

D.M. Manimozhi*, S. Sankaranarayanan and G. Sampath Kumar

Mother Teresa Women’s University, Kodaikanal-624 102, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2122-29

2122-2129

1685

1216

34.

PHYTOCHEMICAL STUDY AND ANTIBACTERIAL, ANTIFUNGAL AND ANTIOXIDANT PROPERTIES OF BRIDELIA FERRUGINEA AND PTELEOPSIS SUBEROSA

The antifungal, antimicrobial, antioxidant and cytotoxic activities of methylene chloride, methanol and hydroethanolic extracts of the leaves of Bridelia ferruginea  and sterm bark of Pteleopsis suberosa  were investigated against six Gram Positive and Gram negative strains bacteria and six species of Aspergilus. The antimicrobial activity was investigatedby the microtest method using p-iodonitr...

Latifou Lagnika*, Murielle H.T. Fantodji and Ambaliou Sanni

Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences and Technology, Institute of Applied Biomedical Sciences, University of Abomey-Calavi, 04 BP 0320, Cotonou, Republic of Benin

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2130-36

2130-2136

1927

715

35.

SIMULTANEOUS ESTIMATION OF MOXIFLOXACIN HCl AND BROMFENAC SODIUM IN EYE DROPS BY SPECTROPHOTOMETRIC METHODS

Moxifloxacin Hydrochloride is a fluorinated quinolone antibacterial and Bromfenac Sodium is a non-steroidal anti-inflammatory. The combination formulation is used for the treatment of the reduction of post operative inflammatory conditions of the eye. Three new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Moxifl...

P. J. Vyas*, J. B. Dave and C. N. Patel

Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2137-42

2137-2142

2606

993

36.

ETHANOBOTANICAL AND CURRENT ETHANOPHARMACOLOGICAL ASPECTS OF ARGEMONE MEXICANA LINN: AN OVERVIEW

Argemone mexicana isan indigenous herb commonly known as Prickly poppy. It belongs to the family Papaveraceae. Argemone mexicana is noted to possess medicinal benefits in traditional system of medicine. During last few decades, there has been increasing interest in the study of medicinal properties of this plant and it is reported for Antimicrobial, Antidiabetic, Antioxidant and Hepatoprotective a...

Charles Lekhya Priya and Kokati Venkata Bhaskara Rao*

Molecular and Microbiology Research Lab., Environmental Biotechnology Division, School of Bio Sciences and Technology, VIT University, Vellore-632 014, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2143-48

2143-2148

1687

601

37.

STORAGE OF WORKING STANDARDS IN POLYPROPYLENE CONTAINERS, ITS EFFECT, CONTAMINANTS AND IMPACT ON ANALYSIS ON LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROSCOPY

Authorspropose a method to determine the contamination caused during the storage of colchicine stock solution, which will be helpful for the bioanalytical scientists. The process of identification of impurities, exceptionally in this case, started from the point of optimization of the compound, where in the parent ion was not detected and instead an unknown mass is being interpreted by the detecto...

A. Krishna Chaitanya*, R. Chelladurai and Rajaram S. Patil

Flat No: 703, B-Wing, Maruti Towers, Sector No:5, Plot No:9, Kamothe, Navi Mumbai-410209, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2149-53

2149-2153

1187

355

38.

EVALUATION OF ANTIMICROBIAL PROPERTIES OF N-HEXANE EXTRACT OF THE LEAVES OF NAPOLEONEAE IMPERIALIS FAMILY LECYTHIACEAE

Napoleonaea imperialis is used to treat wounds in most parts of Nigeria. Against this background, N-hexane extract of the leaves were screened against some microorganisms to ascertain this claim and to recommend it for further investigation for possible inclusion into official compendium. The plant leaves were dried, powdered and extracted by cold maceration with N-hexane for 24hours. Phytochemica...

C.F. Anowi , A.F. Onyegbule *, T.H. Gugu and U.A. Utoh- Nedosa

Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2154-58

2154-2158

1277

416

39.

DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ABACAVIR AND LAMIVUDINE IN COMBINED TABLET DOSAGE FORM USING MULTICOMPONENT MODE

A simple, accurate, precise, economical analytical method has been developed for the simultaneous estimation of abacavir and lamivudine in pure bulk drug and in combined tablet dosage form by UV spectrophotometry in multicomponent mode. The standard solutions of abacavir and lamivudine in mixture of acetonitrile and methanol were diluted with distilled water individually to get the concentration o...

V. P. Nagulwar* and K.P. Bhusari

Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2159-62

2159-2162

1150

534

40.

SIMULTANEOUS DETERMINATION OF VITAMINS B1, B2 AND B6 IN MULTIVITAMIN TABLET AND BIOLOGICAL FLUID BY RP-HPLC

Multivitamin tablets containing various substances of varying characteristics may have a problem in quantitative analysis. This research has developed HPLC method for simultaneous determination of three vitamin components that is thiamine (Vit. B1), riboflavin (Vit. B2) and pyridoxine (Vit. B3) in tablet formulation. The chromatographic separation was achieved by using a C-18 column with dimension...

Himesh Soni*, A.K. Singhai, Kaushelendra Mishra & Sarvesh Sharma

Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal- 462 021, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2163-67

2163-2167

2220

588

41.

INVESTIGATION ON THE IMPACT OF CORE AND BARRIER LAYER COMPOSITION ON THE DRUG RELEASE FROM A TRIPLE LAYER TABLET

In this study, Monolayer matrix (MLM) tablet and triple layer matrix (TLM) tablet formulation of metoprolol succinate were fabricated by using Hydroxypropyl-methylcellulose and Polymethacrylates (Eudragit) as the matrix forming agent in both the tablet core layer and barrier layers. The prepared tablets were analyzed for their drug content and in-vitro drug release studies.  In-vitro evaluation a...

Kanwarpreet Singh Bakshi*, K. Vivek, Rajan K. Verma, Murali Krishna B., Sreekanth Narravula, Romi Barat Singh and Ajay K. Singla

NDDS Department, Ranbaxy Laboratories Ltd., (R & D-2), Plot No 20; Sec 18, Sarhaul, Udyog-Vihar, Gurgaon- 122015, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2168-79

2168-2179

1198

460

42.

FORMULATION AND EVALUATION OF MICROCRYSTALLINE TAPIOCA STARCH AS A FILLER-BINDER FOR DIRECT COMPRESSION

Tapioca starch (NTS) was modified physically at molecular level by annealing and subsequently subjected to enzyme hydrolysis to obtain a more functional filler-binder “microcrystalline tapioca starch (MCTS)”. NTS was extracted from cassava tuber (Mannihot esculenta cranzt) using a standard method. The powder suspensions were prepared in concentration of 40 %w/w in five separate conical flasks....

A.O. Shittu*, A.R. Oyi , A.B. Isah , S.O. Kareem and M.A. Ibrahim

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Science, University of Jos, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2180-90

2180-2190

1579

862

43.

DRUG USE EVALUATION OF CEFTRIAXONE: THE CASE OF AYDER REFERRAL HOSPITAL, MEKELLE, ETHIOPIA

Assessment of antimicrobial use can be performed by evaluating their use. Drug use evaluation is a performance improvement method that focuses on evaluation and improvement of drug use processes to achieve optimal patient outcomes. The objective of this study was to evaluate the rational use of ceftriaxone in Ayder referral Hospital, Mekelle-Ethiopia.  Retrospective cross sectional study was used...

Firehiwot Amare Abebe , Derbew Fikadu Berhe*, Abera Hadgu Berhe , Hailemichael Zeru Hishe and Melaku Asfawuwessen Akaleweld

Mekelle University, College of Health Sciences, Department of Pharmacy, Pharmacology and Therapeutics Course and Research Team, Mekelle-Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2191-95

2191-2195

2769

1605

44.

EVALUATION OF MURRAYA EXTRACTS FOR CONTROLLING FUNGI GROWTH ON ZAPOTA THROUGH ESTIMATION STUDIES

Medicinal plants are various plants which are used in herbalism having medicinal properties. Few plants or their phytochemical constituents have been proven to have medicinal effects by rigorous science or have been approved by regulatory agencies. Shade dried leaves of Murraya koenigii was extracted using successive solvent extraction method using ethanol, chloroform and aqueous. Qualitative ph...

Bertha Fernandes, Lourdes Pereira, Tricia Pereira and Shruthi SD*

P.G. Department of Biotechnology, The Oxford College of Science, Bangalore- 560 102, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2196-00

2196-2000

1443

450

45.

DIURETIC AND NEPHROPROTECTIVE ACTIVITY OF FRUITS OF FRAGARIA VESCA LINN.

Diuretic activity and nephroprotective activity of different extracts of fruits of fragaria vesca in rat was studied. The study suggested that the extracts have good diuretic property. Diuretic study was carried out as per Lipschitz method. Where successive aqueous, ethonolic and petroleum extracts were studied for diuretic activity. The 6 hrs acute study of successive aqueous, ethonolic extracts ...

R. Naga Kishore*, N. Anjaneyulu, M. Naga Ganesh, K. Pruthviraj and N. Sravya

Department of Pharmacology, Geethanjali College of pharmacy, Cheeryal (V), Keesara (M)- 501 301, R.R. District, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2201-04

2201-2204

1909

769

46.

TORSION OF FALLOPIAN TUBE, FIMBRIAL CYST: A RARE CASE REPORT

Fallopian tube torsion or fimbrial cyst torsion is rare, therefore diagnosis may be delayed. Isolated twisting of fallopian tubes is an uncommon event. The frequency is 1/1,500,000 women. Right fallopian tube is most commonly affected. The condition is frequently misdiagnosed with acute appendicitis or ovarian torsion. The torsion of fallopian tube and para-ovarian cyst is usually seen in reproduc...

Shashidhar Boraiah*, Sheela S.R., Chandramouli and Prem Sai Reddy

Sri DevrajUrs Medical College, Kolar- 563 101, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2205-07

2205-2207

1766

488

47.

ANALYSIS OF VARIOUS METAL IONS IN SOME MEDICINAL PLANTS USING ATOMIC ABSORPTION SPECTROPHOTOMETER

Metal ions such as  iron , lead, copper, nickel, cadmium , chromium and zinc were investigated in medicinally important plants Alstonia scholaris, Tabernaemontana coronariae, Asparagus racemosus, Mimosa pudica, Leucas aspera and  Adhatoda vasica applying atomic absorption spectrophotometer  techniques. The purpose of this study was to standardize various metal ion Contamination in indigenous me...

Y.L. Ramachandra*, C. Ashajyothi and Padmalatha S. Rai

Department of P.G. Studies and Research in Biotechnology, Kuvempu University, Jnana Sahyadri, Shankaraghatta - 577 451, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2208-12

2208-2212

1247

484

48.

QUANTIFICATION OF GALLIC ACID AND ELLAGIC ACID IN ARJUNARISHTA BY VALIDTAED HPTLC DENSITOMETRY

Arjunarishta, also known as Parthadhyarishta, is a polyherbal hydro alcoholic formulation and is advised as a choice of remedy in cardiovascular disorders. A simple, precise and accurate HPTLC method has been established for the determination of quercetin and rutin in Arjunarishta–T and Arjunarishta-M prepared by traditional and modern methods respectively and also in its marketed formulation. T...

Preeti Tiwari* and Rakesh K. Patel

Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2215-23

2215-2223

2136

896

49.

ANTIOXIDANT ACTIVITY OF RUBIA CORDIFOLIA AGAINST LEAD TOXICITY

To evaluate the in vivo antioxidant activity of alcoholic extract of the roots of Rubia cordifolia (RC).  Male mice, were exposed, either to a diet containing 40mg/kg body weight of Pb nitrate or combined with Rubia cordifolia for the first period of 40 days, where the animals were sacrificed for oxidative studies. Ingestion of Pb (NO3)2 was significantly decreased RBC count, WBC count, Hb level ...

Shweta Lodia* and Leena Kansala

Department of Bioscience and Biotechnology, Banasthali University, Banasthali, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2224-32

2224-2232

1804

922

50.

ANTIOXIDANT, CYTOTOXIC AND ANTIMICROBIAL ACTIVITY OF SONNERATIA ALBA BARK

The present study was undertaken to evaluate antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba bark. The carbon tetrachloride,  chloroform  soluble partitionate of methanolic extract and crude methanolic extract showed significant antioxidant property using 1,1-diphenyl-2-pecrylhydrazyl(DPPH) scavenging assay ,of which chloroform partitionate and crude extract demonstrated hig...

Md. Ali Milon*, Md. Abdul Muhit , Durajan Goshwami , Mohammad Mehedi Masud and Bilkis Begum

Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2233-37

2233-2237

1539

684

51.

IN VITRO EFFECT OF MITRAGYNINE (A MAJOR ALKALOID OF MITRAGYNA SPECIOSA KORTH) ON AMINOPYRINE METABOLISM IN RAT HEPATOCYTES

Mitragyna speciosa Korth. is a member of the Rubiaceae family. More than 25 alkaloids have been isolated from Mitragyna speciosa. Mitragynine is the major alkaloid of this plant and is responsible for antinociceptive action. No single study is available about the effect of mitragynine on aminopyrine N-demethylase activity in rat hepatocytes. Experiments were undertaken to evaluate the effect of mi...

Rukhsana Anwar & , Abas Hj Hussin , Sabariah Ismail* and Sharif Mahsufi Mansor

Associate Professor, Centre for Drug Research Universiti Sains Malaysia, Pulau Penang- 11800, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2238-42

2238-2242

1701

457

52.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND Zn(II) COMPLEXES WITH SCHIFF BASE (E)-4-[(HYDROXYL PHENYLIMINO)METHYL]BENZENE-1, 2-DIOL

Schiff base ligand (E)-4-[(hydroxyl phenylimino)methyl]benzene-1, 2-diol (H3L) was prepared from the condensation reaction of Protochatechu aldehyde (3, 4-dihydroxybenzaldhyde) with 2-amino phenol. From the direct reaction of the ligand (H3L) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II) nitrates in 2M:1L molar ratio, the five new neutral complexes were prepared. The characteriza...

A.M. Hassan, A.M. Nassar*, Y.Z. Ahmed and A.N. Elkmash

Chemistry Department, Alazhar University, Faculty of Science (Boys), Nasr city, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2243-51

2243-2251

1282

829

53.

A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF LORNOXICAM EMPLOYING HP-β-CYCLODEXTRIN AND SURFACTANTS

Lornoxicam, a widely prescribed anti-inflammatory and analgesic drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It is practically insoluble in water and aqueous fluids. As such its oral absorption is dissolution rate limited and it requires enhancement in solubility and dissolution rate for increasing its oral bioavailability...

S.Z. Chemate* and K.P.R. Chowdary

Padmashri Dr. Vitthalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat, Ahmednagar-414111, Maharashra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2252-56

2252-2256

2868

706

54.

SEPARATION AND ESTIMATION OF COMPONENTS PRESENT IN EMBLICA OFFICINALIS: A PRELIMINARY INVESTIGATION ON ALLERGIC REACTIONS

Indian Gooseberry, Emblica officinalis is a, fruit widely accepted in Kerala for its medicinal & nutritive values. The fruit has dark green colored spherical seed surrounded by pale green colored tissue. Different varieties of food products, pickles being the major one, are used all over the world .The present work on gooseberry originated from a real medical case history. The medical reports ...

Kuzhipalli Parayakode Greeshma* and Mudhirakandi Arumugham Manikandan

Sona College of Technology, Salem - 636 005, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2257-62

2257-2262

1478

359

55.

IN-VITRO ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF HYDROMETHANOLIC EXTRACT OF AVERRHOA BILIMBI L. FRUITS

Averrhoa bilimbi Linn. (Family: Oxalidiaceae) is a medicinal plant which is extensively used in traditional medicine to cure cough, cold, itches, boils, rheumatism, syphilis, diabetes, whooping cough, and hypertension. In this study, hydromethanolic extract of A. bilimbi fruits was examined for its antioxidant action using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and total antioxid...

Sabiha Sultana Chowdhury* , Golam Mezbah Uddin , Nazia Mumtahana , Mokarram Hossain and S.M. Raquibul Hasan

Department of food Science & Nutrition, Pukyong National University, Busan 608-737, Republic of Korea

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2263-68

2263-2268

4186

875

56.

SYNTHESIS AND SPECTRAL STUDY OF 2-(4-{[(SUBSTITUTEDPHENYL)IMINO]METHYL}PHENOXY)ACETO HYDRAZIDE

Heterocyclic Compounds having a valuable place in a Heterocyclic Chemistry and Heterocyclic Compounds having an excellent properties such as drugs, dyes etc, These compounds shows anti-microbial, anti-fungal, anti-bacterial, anti-inflammatory, anti-diabetic, anti-hypertensive etc. properties. In present investigation, we have prepared 2-4-{[(substitutedphenyl)imino]methyl} phenoxy)acetohydrazide f...

Pinka Patel , Deepa Gor and P.S. Patel*

Department of Chemistry, Sheth L.H. Science College, Mansa, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2269-71

2269-2271

1192

545

57.

EVALUATION OF ANTIVENOM ACTIVITY OF CALOTROPIS GIGANTEA PLANT EXTRACT AGAINST VIPERA RUSSELLI SNAKE VENOM

Ethnopharmacological relevance: Calotropis gigantea is usedtraditionally to treat common diseases such as fever, rheumatism, indigestion, cough, cold, eczema, asthma, elephantiasis, nausea, vomiting and diarrhoea, either alone or with other medicines Aim of the study: To evaluate the antivenom activity of Calotropis gigantea plantextract against Vipera russelli snake venom  Mate...

Nimmy Chacko*, Mohammed Ibrahim , Prerana Shetty and C.S. Shastry

Department of Pharmacology, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Manglore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2272-79

2272-2279

2724

840

58.

EFFECT OF EUGENOL EMULSION ON SHELF LIFE OF GRAPES AND STRAWBERRY

In present study, eugenol (major functional component of essential oil of Syzygium aromaticum (clove), at 2% level (v/v) was incorporated in peanut oil based coating to get antimicrobial emulsion. Eugenol emulsion thus prepared was applied on grapes and strawberries. After applying emulsion, reference fruits were kept in corrugated fiber boxes for 8 days for shelf life studies under ambient condit...

Mamta Bhatia* and Alka Sharma

Department of Food Technology, Guru Jambheshwar University of Science and Technology, Hisar-125 001, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2280-82

2280-2282

1516

392

59.

A COMPARATIVE STUDY OF DOT AND SAT IN RURAL TERTIARY CARE HOSPITAL: A TWO YEARS RETROSPECTIVE STUDY

Directly observed therapy (DOT) of tuberculosis patients talking their drugs is supposed to improve treatment completion and outcome .we compared DOT and Self Administered therapy (SAT), in which patients on the same drug regimen are not, observed taking their pills, to assess the effect of each on the success of tuberculosis treatment. This was the two year (2010 and 2011) retrospective study of ...

Jagadish Babu D.* and K. Jyothi

Department of Clinical Pharmacy, SAC College of Pharmacy, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2283-86

2283-2286

1236

543

60.

STUDIES ON SOME BIOCHEMICAL CHANGES DURING CITRIC ACID PRODUCTION IN A SYNTHETIC MEDIUM BY A MUTANT ASPERGILLUS NIGER AB1801

An experimental study was carried out to examine the biochemical changes in the fermentation broth during citric acid production by a mutant Aspergillus niger AB1801. The production of citric acid was increased upto 8th day of fermentation, and then declined. pH decreased continuously, dry cell weight followed continuous increment pattern. Amino nitrogen and urea nitrogen decreased gradually, but ...

P. Ghosh, S. Ganguly* and A. K. Banik

Department of Chemical Engineering (Biochemical Engineering Division), University of Calcutta, 92, A. P. C. Road, Kolkata- 700 009, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2287-90

2287-2290

1075

453

61.

PHARMACOGNOSTICAL AND PHYSICOCHEMICAL STUDIES ON THE LEAVES OF BARLERIA PRIONITIS (L.)

The Barleria prionitis Lin. (Acanthaceae), known as Vajradanti & Porcupine flower, is widely used in traditional medicine. According to survey, any report was not available on microscopic and physicochemical properties of Barleria prionitis Lin. The present study deals with Pharmacognostical examination and physicochemical constant of Barleria prionitis Lin. leaf. The leaf has antiseptic prope...

Usha Vasoya

Department of Pharmacognosy, C. K. Pithawalla Institute of Pharmaceutical Science & Research, Surat, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2291-95

2291-2295

1520

756

62.

PHARMACOGNOSTIC EVALUATION OF CISSUS QUADRANGULARIS L. STEM

 Cissus quadrangularis L. (Vitaceae) is a common perennial climber also called Asthisamhara meaning bone setter is prescribed both in Ayurveda as well as Unani systems for its medicinal use. Pharmacognostic evaluation of Cissus quadrangularis stem revealed a stomatal index of 151 with Stephanocytic stomata in the epidermal peeling. The anatomical section of the stem showed deposits of characteris...

R. Anitha* and P. Suji

Department of Plant Biology and Plant Biotechnology, Ethiraj College for Women, Ethiraj salai, Egmore, Chennai-600 008, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2296-00

2296-2300

1709

635

63.

SIMPLE AND SENSITIVE VALIDATED REVERSE PHASE HPLC-UV METHOD FOR THE DETERMINATION OF LYMECYCLINE IN PHARMACEUTICAL DOSAGE FORMS

A Simple, Sensitive, Precise, and specific reverse phase high performance liquid chromatographic method has been developed for the determination of lymecycline in pharmaceutical Dosage Forms. Chromatographic separation was achieved on a PLRP-S (250×4.6 mm), 8.0 µm make: Varian column with a 11.5:10:20:1:57.5 mixture of 2-Methyl-2-propanol,3.5% w/v  di-potassium hydrogen  phosphate, 1.0% w/v Te...

T. Nageswara Rao, T.B. Patrudu , T. Srinivasa Rao and T. Parvathamma

Research Scholar, Department of Analytical Chemistry, International Institute of Biotechnology and Toxicology (IIBAT), Padappai-601 301, Kanchipuram District, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2301-05

2301-2305

1938

953

64.

VALIDATION OF CLEANING PROCEDURE FOR ELIMINATION OF OFLOXACIN AND METRONIDAZOLE BENZOATE FROM MIXING EQUIPMENT BY USING UV SPECTROSCOPY

This research manuscript describes simple, sensitive, accurate, precise and repeatable UV spectroscopic method for the simultaneous determination of Metronidazole (MET) and Ofloxacin (OFL) in suspension dosage form). Metronidazole has absorbance maxima at 318.0 nm and Ofloxacin has absorbance maxima at 294 nm in Methanol and Water (50:50) solvent. The linearity was obtained in the concentration ra...

Nirav B. Patel*, Sneha K. Jansari , Alpesh C. Arvadiya and Hemant T. Desai

QC Chemist, Nirlife Healthcare (Healthcare Division of Nirma), Sachana (382150), Ahemdabad, Gujrat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2306-095

2306-2309

1643

832

65.

PROCESS VALIDATION OF SOTALOL HYDROCHLORIDE TABLETS

Process Validation is a very common term in the pharmaceutical industry. But it involves series of activities carried out in order to have the assurance that the desired quality products are manufactured. The manufacturing process need to be controlled and for this one should have sound knowledge and understanding regarding the process as well as the product. Each and every step should be scientif...

J.N. Malukani*, R. Sen and H. Raj

Research Scholar, Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2310-165

2310-2316

1365

458

66.

DEVELOPMENT OF UV SPECTROPHOTOMETRIC FIRST ORDER DERIVATIVE METHOD FOR THE SIMULTANEOUS ESTIMATION OF RITONAVIR AND LOPINAVIR IN COMBINED TABLET DOSAGE FORM

A simple, accurate, precise analytical method has been developed for the simultaneous estimation of ritonavir and lopinavir in pure bulk drug and in combined tablet dosage form by UV spectrophotometry by first order derivative method. The standard solutions of ritonavir and lopinavir were prepared in acetonitrile followed by further required with the same solvent.  The solution containing ritonav...

V. P. Nagulwar* and K.P. Bhusari

Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2317-20

2317-2320

1395

516

67.

VOLTAMMETRIC DETERMINATION OF OLOPATADINE HYDROCHLORIDE IN BULK DRUG FORM AND PHARMACEUTICAL FORMULATIONS

The voltammetric behavior of olopatadine was investigated at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of carbon-carbon double bond. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetr...

N.Y. Sreedhar*, A. Sreenivasulu, M. Sunil Kumar and M. Nagaraju

Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2320-24

2320-2324

1208

376

68.

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE CELECOXIB FOR PARENTERAL FORMULATIONS

Celecoxib, a diaryl substituted pyrazole, is practically insoluble in water which precludes its use in parenteral and liquid dosage forms. This study explores the solubility enhancement of celecoxib using hydrotropy and cosolvency solubilization approaches. The equilibrium solubility studies were performed using hydrotropes piperazine, sodium citrate, and urea and cosolvents PEG 200, PEG 400, PEG ...

Shikha Agrawal*, Nidhi Soni , Narendra. K. Jain and G. P. Agrawal

Reader, Swami Vivekanand College of Pharmacy, Near Toll Naka, Khandwa Road, Indore – 452020, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2325-36

2325-2336

5977

815

69.

EFFECT OF LUMINAL pH CHANGES ON GUAR GUM-HPMC E15 LV MIXED MATRIX TABLETS FOR MESALAMINE DRUG DELIVERY TO COLON AND STUDY ON IN- VITRO CHARACTERISTICS IN TWO DIFFERENT DISSOLUTION MODELS vs. MARKETED FORMULATION

The study was designed to investigate the impact of colonic pH changes on formulated colon targeted Mesalamine matrix tablets in the treatment of inflammatory bowel disease (IBD). Mesalamine tablets were fabricated with guar gum as Polymer system. The different batches of Mesalamine tablets (GMM1-GMM6) were compressed with increasing proportion of guar gum and HPMC E15 LV. The different buffer con...

A. Maria John Newton*, L. Prabakaran and K.N. Jayaveera

Nirmala College of Pharmacy, Atmakuru-522 503, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2337-47

2337-2347

1806

455

70.

STUDY OF PRESCRIBING PATTERNS OF ANTIMICROBIAL AGENTS IN THE PAEDIATRIC WARDS AT TERTIARY TEACHING CARE HOSPITAL, GUJARAT

Background: Prescription of drugs, which needs to be continuously assessed and refined according to disease progression. It not only reflects the physician’s knowledge about drugs but also his/her skill in diagnose and attitude towards selecting the most appropriate cost-effective treatment. Antimicrobials are among the most commonly prescribed drugs in hospital. As per literature, they account ...

Vipul Prajapati* and J.D. Bhatt

M.B.B.S, M.D (Pharmacology), Assistant Professor, Department of pharmacology, AMC MET Medical College, Ahmedabad-380008, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2348-55

2348-2355

1850

556