Pages Menu
TwitterRssFacebook
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

Categories Menu

Volume 7 (2016) - Issue 12, December

Review Articles

 
Title
Views
PDF
Cited
1.

A REVIEW ON ETHNOPHARMACOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGY OF BUDDLEJA ASIATICA

Buddleja asiatica commonly called as butterfly bush is a tender deciduous plant. It is endemic to Asia and found in most parts of India. Traditionally it is used in the treatment of many health disorders such as inflammation, rheumatism, skin disease, malaria etc. In view of pharmacological aspect, Buddleja asiatica is screened for antihepatotoxic, antibacterial, hypotensive, anticancer, antifunga...

S. Raja * and I. Ramya

GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4697-09

4697-4709

3789

1206

2.

SALVIA GENUS AND TRITERPENOIDS

Salvia L., is one of the largest genera from Lamiaceae (Labiatae) family which comprises 900 species and is widely distributed in various regions of the world like in America, Europe, Asia. In this review article, the triterpenoid constituents were investigated from all of the Salvia plants to date are reported. About 214 triterpenoids of different classes were isolated and characterized from 113 ...

Shyamal K. Jash, Dilip Gorai and Rajiv Roy*

Independent Researcher, Bhatgonna (Dignagar), Burdwan, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4710-32

4710-4732

2954

1074

3.

EMULGEL-NOVEL TOPICAL DRUG DELIVERY SYSTEM–A COMPREHENSIVE REVIEW

Emulgel systems are currently of attention to the pharmaceutical scientists because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules. These are either emulsion of water in oil type or oil in water, which is gelled by mixing it with a gelling agent. Incorporation of emulsion into gel makes it a dual control release system & also inc...

Davinder Kumar, Jasbir Singh, Mamta Antil and Virender Kumar *

College of Pharmacy, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, University of Health Sciences, Rohtak, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4733-42

4733-4742

5642

1344

4.

AYURVEDIC NATURAL EXCIPIENTS: AN ADVANCE OPTION FOR MODERN MEDICAMENTS

Excipients are important partner in formulation that decide dosage form as well as Pharmacokinetics and pharmacodynamics of medicament. In contemporary era, excipients are used from synthetic resources, causes unwanted effect in pharmaceutics and therapeutics. So industries are looking towards natural resources as it delivers safe, biodegradable, cost effective, biocompatible and inert excipient t...

V. K. Singh and A. K. Chaudhary *

Department of Rasa Shastra, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh India

DOI: 10.13040/IJPSR.0975-8232.7(12).4743-55

4743-4755

8032

1214

5.

KAWASAKI SYNDROME- A REVIEW

Aim: The aim of this review is to provide a detailed documentation and main features such as prevalance, manifestations and management regarding Kawasaki syndrome. Background: Kawasaki Syndrome was first described by Dr Tomisaku Kawasaki in Japan in 1967, since then prevalence of Kawasaki syndrome is increasing in all countries as per the reports in journals. This is more prevalent in Asian pacifi...

T. Priadarsini

Saveetha Dental College and Hospitals, Saveetha University, 162, P.H Road, Chennai-77, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4756-61

4756-4761

2751

797

Research Articles

 
Title
Views
PDF
Cited
6.

THE IMPACT OF ADENOSINE A2B RECEPTORS MODULATION ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA CO-ACTIVATOR 1-ALPHA AND TRANSCRIPTION FACTORS

Previous studies have demonstrated that the activation of adenosine A2B receptors increases adenosine 3'-cyclic monophosphate (cAMP) accumulation in rat skeletal muscle cells, which is probably an important yet unknown mechanism contributing to the regulation of skeletal muscle functions. via rat L6 skeletal muscle cells, it has been elucidated further potential molecular signaling responsible for...

Mansour Haddad *

Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan

DOI: 10.13040/IJPSR.0975-8232.7(12). 4762-76

4762-4776

2662

737

7.

REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ESTIMATION OF BIOACTIVE COMPOUNDS FROM DIFFERENT FRACTIONS OF NEW POLYHERBAL FORMULATION OF CLINACANTHUS NUTANS AND ELEPHANTOPUS SCABER

Background: Polyherbal formulation is the trend of modern pharmacognosy and holistic approach in the treatment of uncurable diseases such as cancer. Medicinal plants contain many bioactive compounds that give different pharmacological activities. Therefore, it is important to investigate the quality of new polyherbal formulation by identification of bioactive markers. Objective:  To identify apig...

Md. Shahzad Aslam *, Md. Syarhabil Ahmad , A. S. Mamat , Md. Z. Ahmad and F. Salam

School of Bioprocess Engineering , Universiti Malaysia Perlis, Kawasan Perindustrian Jejawi, Arau, Perlis, Malaysia

DOI: 10.13040/IJPSR.0975-8232.7(12).4778-86

4778-4786

3109

830

8.

GRAPE SEED EXTRACTED (VITISVINIFERA) ALLEVIATE HEPATIC TOXICITY INDUCED BY THE ANTI-OESTROGEN TAMOXIFEN IN FEMALE ALBINO RATS

Aim: The present study has been undertaken to investigate the therapeutic effect of GSE (Grape seed extracts) against Tamoxifen (TAM), induced hepatotoxicity in rat. Methods: The rats were divided into four groups • Group 1: rats were injected intraperitoneally (i.p.) with saline for seven days. • Group 2: Rats were treated with TAM in a dose of 45 mg/kg b·w/day, i.p., for seven successive da...

Eman Mohammed Mohammed Abd-Ella *

Lecturer of Histology and Histochemistry, Zoology Department, Faculty of Science, Fayoum University, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(12).4787-97

4787-4797

2755

712

9.

INVESTIGATION OF HEAVY METALS CONTENT IN SELECTED TEA BRANDS MARKETED IN PODGORICA, MONTENEGRO

Medicinal plants are sources of different chemical substances with different biological activities in living organism. Some of the chemical compounds so-called “heavy metals”, can be dangerous because they tend to bioaccumulate and transported in all biota via the food chain. The aim of our study was to investigate the concentration of heavy metals in commercially available tea samples purchas...

Vera Dabanović *, Miomir Šoškić , Dijana Đurović and Boban Mugoša

Pharmacy Institution of Montenegro "Montefarm" , Ljubljanska bb, Podgorica, Montenegro

DOI: 10.13040/IJPSR.0975-8232.7(12).4798-04

4798-4804

3344

781

10.

EFFICACY OF SECURIDACA LONGEPEDUNCULATA ON THE PARAMETERS OF BLOOD GLUCOSE LEVEL AND PULSE RATE OF ENVENOMED ALBINO RATS

The study was undertaken to investigate the in vivo activity of aqueous and ethanol extracts of Violet plant, Securideca longepedunculata leaves and root bark against snake venom of Naja nigricollis and blood glucose level along with pulse rate in experimental albino rats. Healthy adult albino rats weighing 250-300g were used and randomly divided into five groups for in vivo anti-snake venom activ...

J. Sanusi , J.A. Bawa * , I.S. Aghemwenhio , Z.S. Rabi’u , M.G. Sani and S. Liadi

Biology Department, Isa Kaita College of Education Dutsin-ma, Katsina State Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(12).4805-11

4805-4811

2707

872

11.

ANTIDIABETIC AND HAEMATOLOGICAL EFFECT OF MYRIANTHUS ARBOREUS P. BEAUV. STEM BARK EXTRACT IN STREPTOZOTOCIN – INDUCED DIABETIC RATS

The increasing prevalence of diabetes mellitus worldwide is an issue of major socio-economic concern especially in Sub - Saharan Africa. Indigenous medicinal plants are used for the treatment of diabetes mellitus in most developing countries, like Ghana, but remain to be validated. In the present study, the effect of Myrianthus arboreus ethanol stem bark extract (MAB) (100 - 400 mg/kg) on glucose ...

R.A. Dickson, B. K. Harley *, D. Berkoh, R.A. Ngala, N.A. Titiloye and T. C. Fleischer

Department of Pharmacognosy, Faculty of Pharmacy, College of Health Sciences, KNUST, Kumasi/ Ghana

DOI: 10.13040/IJPSR.0975-8232.7(12).4812-26

4812-4826

2055

489

12.

THE EFFECT OF NECA, CGS 21680, PSB 603 ON FATTY ACID TRANSPORT AND OXIDATION IN SKELETAL MUSCLE CELLS

Adenosine is a strong modulator of gene expression, which underpins some of its potential expected effects in skeletal muscle in terms of fatty acid metabolism.  Accumulating evidence highlights a critical role for the adenosine system in the regulation of fatty acid metabolism and obesity. However, its molecular signaling role in fatty acid transport and oxidation in skeletal muscle is less clea...

Mansour Haddad

Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan

DOI: 10.13040/IJPSR.0975-8232.7(12). 4827-38

4827-4838

1630

345

13.

EXTENT OF PHOTO-DEGRADATION OF THREE DIFFERENT DIAZEPAM TABLET FORMULATIONS AVAILABLE IN TRANSPARENT PACKAGING: AN UV ANALYSIS

This study was designed to determine the extent of photolytic degradation of diazepam tablets, without light-protective packaging, available in the market. The UV spectroscopy method was designed and applied for this purpose. A total of 2160 tablets (each tablet contained 5 mg diazepam) of three different brand formulations A, B and C were chosen randomly. These tablets were then exposed to differ...

Md. Anisur Rahman *, Tirtha Nandi, Mohammed Faisal Bin Karim, Nuzhat Ahsan, Sumaiya Khondokar Mitu and Irin Sultana

Department of Pharmacy, East West University, Dhaka, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.7(12).4839-47

4839-4847

2224

589

14.

ASSOCIATION OF THE APOLIPOPROTEIN B/APOLIPOPROTEIN A-1 RATIO WITH THE SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Although many studies have demonstrated the importance of the apoB/apoA-1 ratio as a risk marker of atherogenicity, less is known about apoB/apoA-1 ratio in predicting and the severity of coronary artery disease (CAD) in T2DM. Our study aimed to assess possible associations between apoB/apoA-1 ratio levels and the severity of coronary artery diseases in patients with type 2 diabetes mellitus (T2DM...

N. Bouzidi *, A. Dandana, M. Hassine, L. Khlifi, K. Ben Hamda, H. Chahed, F. Maatouk, H. Gamra and S. Ferchichi

Biochemistry Laboratory, CHU Farhat Hached-Sousse - Research Unit 06/07, Faculty of Pharmacy, University of Monastir, Tunisia

DOI: 10.13040/IJPSR.0975-8232.7(12).4848-55

4848-4855

1474

388

15.

ORAL DELIVERY OF ROSUVASTATIN LIPID NANOCARRIERS: INVESTIGATION OF IN VITRO ANDIN VIVO PROFILE

Present study is a systematic approach to provide ‘proof of concept’ for effective oral delivery of Rosuvastatin lipid nanocarriers for treatment of hyperlipidemia. Rosuvastatin is a ‘Superstatin’ belonging to BCS class II having low bioavailability (20%). Development of lipid nanocarriers for oral delivery of rosuvastatin can be beneficial in enhancing bioavailability and providing sustai...

D. Suares and B. Prabhakar *

Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle (West), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(12).4856-64

4856-4864

2069

501

16.

Prevalence and Co-infection of Cosavirus in Pediatric Patients with Acute Gastroenteritis from North India

Viral gastroenteritis is one of the major causes of childhood mortality in India. About 30 to 50 % gastroenteritis caused by unknown etiological agents. This study was aimed to identify unknown RNA viral etiology and their clinical manifestation with pediatric acute gastroenteritis, conducted at tertiary care hospital of Uttar Pradesh, North India from July 2012 to December 2013. A total of 234 pa...

Richa Kapoor, Ujjala Ghoshal, Sudhir K. Mandal and Tapan N. Dhole *

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4865-72

4865-4872

1539

442

17.

UV ANALYSIS OF THE EXTENT OF PHOTO-DEGRADATION OF THREE DIFFERENT DIAZEPAM TABLET FORMULATIONS UNDER DIFFERENT LIGHT EXPOSURES

This study was designed to determine the extent of photolytic degradation of diazepam tablets, without light-protective packaging, available in the market. The UV spectroscopy method was designed and applied for this purpose. A total of 2160 tablets (each tablet contained 5 mg diazepam) of three different brand formulations A, B and C were chosen randomly. These tablets were then exposed to differ...

Md. A. Rahman *, T. Nandi, Md. Faisal Bin Karim, N. Ahsan, S. Khondokar Mitu and I. Sultana

Department of Pharmacy, East West University, Aftabnagar, Dhaka, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.7(12).4873-81

4873-4881

1511

460

18.

FORMULATION DEVELOPMENT AND SOLUBILITY ENHANCEMENT OF ROSUVASTATIN CALCIUM TABLET PREPARED BY COMPLEXATION WITH β-CYCLODEXTRIN BY KNEADING METHOD

Rosuvastatin is a Dyslipidaemic agent, which acts by inhibiting HMG-CoA reductase enzyme and used in the treatment of hyperlipidemia. But Rosuvastatin calcium (RST) exhibit unsatisfactory dissolution profiles, problems of absorption and poor bioavailability. Thus objective of the study is to increase the solubility and dissolution rate of Rosuvastatin calcium (RST), a poorly water-soluble 3-hydrox...

Kapse Vidya N. *, S. Z. Chemate and V. M. Dharashive

P.D.V.V.P.F’S College of Pharmacy, Vilad Ghat Ahmednagar, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4882-92

4882-4892

3563

706

19.

STUDIES ON ISOLATION, PURIFICATION AND STRUCTURE ELUCIDATION OF CHEMICAL CONSTITUENTS FROM METHANOLIC FLOWER EXTRACT OF BLEPHARIS MOLLUGINIFOLIA PERS. AND THEIR BIOLOGICAL ACTIVITIES

Blepharis molluginifolia (Acanthaceae), is a threatened medicinal herb. The methanolic flower extract of Blepharis molluginifolia was subjected to Silica Gel Column Chromatography for purification of bioactive compounds and structure elucidation of active compounds were studied. DPPH and antimicrobial activities of two isolated compounds were studied. From the analysed data, the compounds identifi...

K. Deepika *, Mahesh Kumar M. V. S. , T. S. D. Radhika and S. V. Rajagopal

Department of Biotechnology, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4893-04

4893-4904

1867

557

20.

MOLECULAR CHARACTERIZATION OF PSEUDOMONAS AERUGINOSA ISOLATES RECOVERED FROM HUMAN PATIENTS IN HIMACHAL PRADESH (INDIA) FOR SELECTIVE GENES: EXTENDED SPECTRUM β-LACTAMASE (ESBL), AMPICILLIN CLASS C (AMPC) AND METALLO β-LACTAMASE (MBL) GENES

The present study highlights the occurrence of β-lactamase (bla) genes belonging to different classes: extended spectrum β-lactamase genes (blaTEM, blaSHV, blaCTX-M and blaPER), metallo β-lactamase genes (blaNDM and blaGIM and Ampicillin class C genes (blaPDC and blaCMY) in P. aeruginosa isolates by PCR amplification. The isolates were recovered from human patients of Indira Gandhi Medical Coll...

Bharti, Naveen Minhas and P. C. Sharma *

Department of Microbiology, School of Biotechnology, Shoolini University of Biotechnology and Management Sciences, Bajhol, Solan (H.P.), India.

DOI: 10.13040/IJPSR.0975-8232.7(12).4905-16

4905-4916

2806

511

21.

THE IMPACT OF ADENOSINE A2B RECEPTORS ON GLYCOLYSIS AND INSULIN RESISTANCE IN SKELETAL MUSCLE

Adenosine has been proposed as a key factor regulating the metabolic balance between energy supply and demand in skeletal muscle. Adenosine A2B receptors are expressed across multiple tissues including skeletal muscle. Previously, it has been identified the robust (in vitro) induction of the nuclear receptors (NR4A) subgroup following adenosine A2B receptors stimulation in rat skeletal muscle cell...

Mansour Haddad

Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan

DOI: 10.13040/IJPSR.0975-8232.7(12). 4917-26

4917-4926

1698

376

22.

COMPARING GREEN CHEMICAL METHODS AND CHEMICAL METHODS FOR THE SYNTHESIS OF TITANIUM DIOXIDE NANOPARTICLES

Metal nanoparticles are usually synthesized using various chemical methods such as chemical reduction, Solvo-thermal reduction, electrochemical techniques and photochemical reaction in reverse micelles. All these methods are divided into two categories chemical and green chemical. Each having certain advantages and disadvantages. In this study we have tried to give a few examples of these methods ...

Shabnam Taheriniya* and Zahra Behboodi

Faculty of Plasma Physics, Islamic Azad University - Science & Research Branch, Tehran, Iran

DOI: 10.13040/IJPSR.0975-8232.7(12).4927-32

4927-4932

3960

846

23.

EFFICACY OF NON POLAR EXTRACT (NPE) OF ALOE BARBADENSIS MILL. IN POLYCYSTIC OVARIAN SYNDROME (PCOS) RODENT MODEL- AN “IN VIVO” STUDY

Aim of the current study was to evaluate the efficacy of non polar extract (NPE) of Aloe vera gel (AVG) for 60 days (~25μg/daily/orally) in rodent model of polycystic ovarian syndrome (PCOS). After treatment, steroid hormones and insulin levels were estimated by ELISA, serum lipid profile along with ovarian steroidal enzyme activity. Also, transcript as well as protein level of key receptors and ...

M. Radha and N. Laxmipriya*

Department of Biochemistry, Faculty of Science, The M S University of Baroda, Vadodara, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4933-48

4933-4948

1624

618

24.

ALLIUM SATIVUM REGULATES LIPID METABOLISM IN ALLOXAN INDUCED DIABETIC RATS

Allium sativum (A. sativum), commonly known as garlic, is a species in the onion genus, Allium. The hypolipidemic activity of A. Sativum (Family: Amaryllidaceae) extract have been studied in alloxan-induced diabetic rats. In this model oral administration of extract (500mg/kg bw., p.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal ...

Prabha Verma *, Brijesh Rathore, Vishnu Kumar, Abbas Ali Mahdi and Raj Kumar Singh

Department of Biochemistry, Maharani Laxmi Bai Medical College, Jhansi,Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4949-55

4949-4955

1614

546

25.

DIAGNOSIS OF NON-POLIO ENTEROVIRAL INFECTIONS IN SEPTIC NEONATES BY POLYMERASE CHAIN REACTION ASSAYS

Objective: The purpose of this study was to investigate the prevalence of non-polio enteroviral infections by quantitative and qualitative PCR assays in neonates 3-30 days old with clinical diagnosis of sepsis. Methods: The patients included all the neonates aged 3-30 days admitted with diagnosis of neonatal sepsis. Blood specimens, throat swabs, and in 60 cases CSF specimens were tested for Enter...

A. A. Razlansari, M. Jamalidoust *, M. Ziyaeyan, M. Shahian, M. Moeini, S. Asaei , Z. Obeidavi and A. Alborzi

Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: 10.13040/IJPSR.0975-8232.7(12).4956-62

4956-4962

1681

473

26.

6-OXA-3-THIAOCTANOIC ACID HAS POTENTIAL INHIBITORS AGAINST THYROID CANCER- IN-SILICO ANALYSIS

Cancer is an uncontrollable incurable disease with abnormal growth and proliferation of cells. Thyroid cancer is caused due to the thyroid hormone effects on growth, development and homeostasis in mammals. Thyroid cancer is the most common endocrine malignancy. Thyroid hormone is encoded by two types of thyroid receptors that are TRα and TRβ. TRα is functionally divided in two types TRα1 and T...

G. Manivel *, P. Senthilraja, S. Manikandaprabhu, G. Durga, M. Prakash and G. Sakthivel

Department of Zoology, Annamalai University, Chidambaram, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(12).4963-70

4963-4970

1782

382

27.

DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR ESTIMATION OF MEPHENESIN AND IBUPROFEN

A new RP-HPLC method was developed for Mephenesin (MEP) and Ibuprofen (IBU) and validated as per ICH guidelines. Good chromatographic separation of Mephenesin and Ibuprofen was achieved by using Agilent C18 column (150mm×4.6mm, 3.2µ p.s). The system was operated at ambient temperature using a mobile phase consisting of Acetonitrile, 0.01M potassium dihydrogen phosphate pH 3.0 (60:40 v/v) isocrat...

L. Dias *, R. Mallya and K. Patani

SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(12).4971-77

4971-4977

2320

496

28.

PRODUCTION OF LACCASE BY NEWLY ISOLATED MARASMIUS SP. BBKAV79 IN SOLID STATE FERMENTATION AND ITS ANTIPROLIFERATIVE ACTIVITY

The aim of the present study was to investigate the production of laccase by Marasmius sp. BBKAV79 in Solid State Fermentation (SSF) and its antiproliferative activity. Experiments were also conducted to determine the variables that could affect activity of laccase. In particular, the effects of the initial moisture content, pH, temperature, and inoculum volume, incubation period in addition to ca...

A. B. Vantamuri and B. B. Kaliwal *

Department of Studies and Research in Biotechnology and Microbiology, Davangere University, Davangere, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4978-87

4978-4987

2142

461

29.

FORMULATION AND EVALUATION OF CO-CRYSTALS OF POORLY WATER SOLUBLE DRUG

The present study is an attempt to formulate and evaluate cocrystals of poorly water soluble drug Darunavir by cooling crystallization method using succinic acid as coformer. Cooling crystallization method used to prepare the cocrystals of darunavir with succinic acid. The prepared cocrystals were characterized by Microscopic characters, Product yield, Surface morphology. (SEM), Differential scann...

Shubhangi A. Bagde *, Kanchan P. Upadhye, Gauri R. Dixit and Suparna S. Bakhle

Department of Pharmaceutics, Priyadarshani J. L. College of pharmacy, Electronic zone, MIDC Hingna road, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(12).4988-97

4988-4997

3053

653

30.

METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF IDELALISIB IN RABBIT PLASMA BY HPLC

A simple, rapid, sensitive, and accurate high performance liquid chromatography was developed for determination of Idelalisib (IL) in rabbit plasma using Ibrutinib as internal standard (IS). Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lympho...

A. Suneetha * and D. Sharmila

Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(12).4998-05

4998-5005

2247

554

31.

OINTMENT OF METHANOLIC EXTRACT OF FICUS RELIGIOSA: A TRADITIONAL APPROACH IN WOUND HEALING IN RATS

The methanolic extract (ME) of leaves of Ficus religiosa (Family: Moraceae) was evaluated for their wound healing activity in rats. It was carried out in rats by employing excision wound models following topical application. The qualitative preliminary phytochemical analysis of ME indicated the presence of tannins, triterpenoids, alkaloids and steroids. All healthy animals of either sex were group...

Reena Gupta* and Jitendra Gupta

Institute of Pharmaceutical Research, GLA University, Chaumuha, Mathura, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5006-11

5006-5011

2105

591

32.

STUDY OF ANALGESIC-NALBUPHINE AS A COMPONENT OF BALANCED ANAESTHESIA IN OTOLARYNGORHINOLOGICAL SURGERY

Back ground: Use of proper analgesics as adjuvant to balanced anaesthesia can calm the patient, reduce stress and decrease the need of higher doses of inhalation agents. Some examples of analgesics are opioids, NSAIDS, NDMA receptor antagonists (ketamine). Nalbuphine is a synthetic opioid agonist-antagonist analgesic of the phenantherene series. We conducted this study with the aim to observe the ...

J. Badheka*, V. Parmar, V.A. Chhaya, N. Patel, K. Ramteke and J. Mehta

Department of Anesthesiology, P. D. U. Medical College, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5012-16

5012-5016

2102

482

33.

EFFICACY OF GARLIC IN CONJUNCTION WITH PENTOXIFYLLINE IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS – A PRELIMINARY STUDY

Introduction and Objectives: Oral submucous fibrosis (OSMF) is a chronic, progressive, and irreversible disease of the oral mucosa. Though numerous modalities have been tried but all are palliative and have no curative value. Pentoxifylline possessing vasorelaxive and antifibrotic properties believed to potentiate the anti-inflammatory, anti-oxidant and immune modulating properties of garlic. So, ...

Nimesh Jain *, Rajeshwari G Annigeri and Pratik R. Pipalia

Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5017-23

5017-5023

2318

475

34.

SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTICANCER EVALUATION OF BIS-[1,5]-BENZOTHIAZEPINES AGAINST HUMAN BREAST CANCER CELL LINE MCF-7

Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell lin...

R. N. Deshmukh and R. V. Dengle *

Department of Chemistry, Vivekanand College, Kolhapur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5024-29

5024-5029

1548

447

35.

DESIGN & DEVELOPMENT OF NOVEL LIPID BASED CARRIER SYSTEM FOR DELIVERY OF PITAVASTATIN CALCIUM

The aim of this work is to prepare self-micro-emulsifying drug delivery system (SMEDDS) for oral bioavailability enhancement of a poorly water soluble drug, Pitavastatin. Solubility of Pitavastatin was determined in various vehicles. SMEDDS is mixture of surfactants, oils and co-surfactants, which are emulsified in aqueous media under conditions of digestive motility and gentle agitation that wou...

Praveen Parashar *, Bharti Mangla and Suresh Kumar Joshi

B. S. Anangpuria Institute of Pharmacy, Faridabad, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5030-38

5030-5038

2069

843

36.

ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF IMPATIENS BALSAMINA SEED (KACI-T-TUMPAI) COLLECTED FROM COIMBATORE DISTRICT, TAMIL NADU, INDIA

The antimicrobial effects of I. balsamina seed hexane extract against Staphylococcus aureus, Klebsiella pneumonia, Proteus vulgaris, and Serratia marcescens were determined using the standard technique. As well as the phytochemical properties of the extract on the test isolates were also examined using the standard methods. The phytochemical components of the hexane extract of the I.balsamina seed...

A. Manikandan *, R. Rajendran, M. Abirami and K. Kongarasi

PG and Research Department of Microbiology, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5039-43

5039-5043

1934

544

37.

DESIGN AND MOLECULAR DOCKING STUDIES OF SOME 1,3,4-THIADIAZOLE DERIVATIVES

In present investigation of some ethyl1-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl) - 5 - ethyl-2, 6-dimethyl – 4 - phenyl-1, 4-dihydro pyridine-3-carboxylate are designed and docked active site of cavity 1# of open channel voltage gated calcium  channel protein (3DVE).  The compounds evaluated in silico (docking) to distinguish their hypothetical binding mode using the X-ray crystal structure ...

Dinesh D. Rishipathak *, Kamlesh V. Patil, Poonam S. Wajpeyi and Madhuri J. Daryani

Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5044-51

5044-5051

1707

446

38.

ENHANCED BIOAVAILABILITY OF GLIMEPIRIDE THROUGH MICROEMULSION BASED TRANSDERMAL GELS

The objective of the present research work was to conduct in vivo pharmacokinetic study of microemulsion based transdermal gel of glimepiride for evaluating the enhanced bioavailability.  Saturation solubility studies of the drug were conducted in various solvents and oils. Labrafil M 1944 CS, Tween 80 and Transcutol P were used as oil phase, surfactant and cosurfactants respectively for the prep...

Kalpana Madikattu *, Venkatasimhadri Naidu Kalamata and K. Srisailam

A.P. Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5052-55

5052-5055

1775

564

39.

ANTIOXIDANT AND ANTILEUKEMIC ACTIVITY OF VITEX NEGUNDO LEAF EXTRACTS

Vitex negundo is an Indian medicinal plant used to cure several diseases such as asthama, fever, headache, cancer and many other diseases. This study aims to determine the antioxidant potential and anti-proliferative activity of Vitex negundo methanolic leaf extract. Isolation of bioactive compounds involved liquid-liquid extraction of methanolic leaf extract by petroleum ether and chloroform. The...

G. N. Shubha *, K. N. Shanti, Rukmini Jonnalagadda, Richa Kamboj and Sucheta Sridhar

Department of Biotechnology, PES Institute of Technology, Bangalore, Karnataka, India

DOI: DOI: 10.13040/IJPSR.0975-8232.7(12).5056-61

5056-5061

2282

458

40.

INVESTIGATION OF BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF EXCOECARIA AGALLOCHA, L.

Mangrove survives in the most hostile environment with fluctuating tidal and saline regime. The present work focused on a detailed study on quantitative estimation of phytoconstituents and DPPH radical scavenging activity of Excoecaria agallocha L., a mangrove from Kattiparambu and Chirackal of Ernakulam District, Kerala. Preliminary phytochemical investigation indicated the presence of biological...

S. Sofia * and Merlee Teresa M. V.

Department of Botany, St. Teresa’s College, Ernakulam, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5062-66

5062-5066

1813

421

41.

PHYTOCHEMICAL EVALUATION AND HPTLC ANALYSIS OF PHOENIX SYLVESTRIS FRUIT EXTRACT AT TWO RIPENING STAGES

Phoenix sylvestris Roxb, commonly known as date sugar palm or wild date palm, grows naturally in the tropics and subtropics of the Indian subcontinent. The present study was aimed for phytochemical evaluation and to develop the high performance thin layer chromatography (HPTLC) fingerprint profile of methanolic extract of P. sylvestris at two ripening stages. The powdered plant material was extrac...

Gangaraju Rapaka *, Archana Bollavarapu and Raghavarao Tamanam

Department of Biochemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(12).5067-71

5067-5071

1881

599

42.

CLINICAL AND RADIOGRAPHIC EVALUATION OF PULPAL AND PERIRADICULAR TISSUE

Objective: The aim of the present study was to evaluate the clinical and radiographic aspects of pulpal and periradicular tissue for patient undergoes endodontic treatment. Patient and method: The present study was limited to patients who treated endodontically by postgraduate students of Conservative Department, School of Dentistry/Faculty of Medical Sciences between January 2014 to February 2015...

Ranjdar Mahmood Talabani *, Azheen Jamil Ali and Bamo Namiq Abdulkareem

Department of Conservative Dentistry, School of Dentistry - Faculty of Medical Sciences/ University of Sulaimani, Iraq

DOI: 10.13040/IJPSR.0975-8232.7(12).5072-76

5072-5076

2511

417

43.

SYNTHESIS, CHARECTERIZATION AND ANTIMICROBIAL ACTIVITY OF 5-METHYL -2, 4-DIHYDRO-3H-PYRAZOL-3-ONE-4-(4-SUBTITUTED) BENZYLPIPERAZINE DERIVATIVES

Synthesis of 6-Methyl-2, 4-dihydro-3H-pyrazol-3-one- 4- (4-substituted) Benzylpiperazine derivatives IVP a-e was carried out by bromination of Ethyl aceto acetate (I) with KBr. The reaction was carried out in the presence of Hydrochloric acid and tolune to produce Bromo-ethyl aceto acetate (II), it is further condensed with substituted Benzylpiperazines in presence of ethanol to obtain condensed c...

Chidara Mahesh * and Satla Shobha Rani

Department of Pharmaceutical Chemistry, Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5077-81

5077-5081

1471

382

44.

A STUDY ON ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE REGARDING PHARMACOVIGILANCE AMONG HEALTHCARE PROFESSIONALS IN A TERTIARY CARE HOSPITAL, ANDHRA PRADESH

Objectives: The aim of this study was to assess knowledge, attitude and practice of the healthcare professionals about Pharmacovigilance in a tertiary care hospital, Rajahmundry, Andhra Pradesh. Materials and Methods: A cross-sectional questionnaire based study was carried out on healthcare professionals (Faculties, Postgraduates, Interns & Nurses) to assess the knowledge, attitude and practic...

Ravi Babu Komaram * and Midan Dhar

Department of Pharmacology, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(12).5082-87

5082-5087

2500

474

45.

THE STUDY OF SERUM VITAMIN D STATUS WITH INSULIN RESISTANCE IN OBESE ADOLESCENTS

Aim: To study the relationship between serum Vitamin D levels and insulin resistance in obese and non obese adolescents. Introduction:   Vitamin D deficiency in obese adolescent is strongly associated with increased risk for diabetes, hyper tension and metabolic syndrome. Vitamin D insufficiency is a risk factor for developing impaired glucose in childhood obesity and is associated with insulin ...

Sarguru Datchinamoorthi *, Vanaja R and Balaji Rajagopalan

Department of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5088-91

5088-5091

1827

469

46.

ANALGESIC DRUGS IN DENTISTRY- A CROSS-SECTIONAL STUDY AMONG DENTISTS IN A PRIVATE DENTAL COLLEGE

Aim: The objective of this survey was to assess the awareness pattern of analgesic administration and the various factors impacting the prescription of analgesics. Materials and methods: Pretested interviewer administered questionnaire was distributed to 100 study subjects consisting of post graduates and dental practitioners in Chennai. The questionnaire was designed to contain questions regardin...

Karishma Ravinthar, E. Devika Warrier and Anitha Roy *

Faculty of Pharmacology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5092-98

5092-5098

2300

532

47.

EVALUTION OF ANXIOLYTIC ACTIVITY OF LEPTADENIA RETICULATA PLANT

The persent study was designed to investigate the anxiolytic activity of ethanolic extract of Leptadenia reticulata plant. It is a folk medicine traditionally used in treatment of eye diseases, seminal debility, general weekness, cough, fever, asthma, sore throat and gonorrhea. The anxiolytic activity was evaluated by Elevated plus maze Test, Light-Dark Test, Hole-board Test and Social-intraction ...

Bhawna Rajpurohit *, Umesh K. Gilhotra, Anil K Verma and Chandan Genwa

G. D. Memorial College of Pharmacy, Jodhpur-342005, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5099-05

5099-5105

1751

576

48.

EXTRACTION OF ESSENTIAL OIL FROM FLOWERS OF MESUA FERREA LINN. GC-MS ANALYSIS AND INCORPORATION IN COSMETIC PRODUCT.

Mesua ferrea Linn. is a flowering tree found in Western Ghats of India, belonging to family Clusiaceae. Extraction process was standardized by cold maceration method with n-hexane. Essential oil extracted from different parts of the flower was also subjected to GC/MS and headspace analysis. The GC/MS analysis of essential oils from whole flowers of M. ferrea shows following components. Alpha-Copae...

N. M. Jadhav, R. S. Thergaonkar and M. A. Deodhar *

Department of Botany, Kelkar Education Trust’s V. G. Vaze College of Arts, Science and Commerce, Mithagar Road, Mulund (E) Mumbai, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5106-10

5106-5110

2566

491

49.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF AZELNIDIPINE

A simple and precise method was developed for the assay of azelnidipine from tablet formulation. The solvent system and wavelength were optimized in order to maximize the sensitivity of the proposed method, azelnidipine shows the maximum absorbance at 257 nm. The separation was achieved on HPLC binary gradient system equipped with HPLC 3000 series. The mobile phase was prepared with Methanol: Wate...

Megha G. Gore * and Pratap S. Dabhade

SND College of Pharmacy, Babhulgaon, Yeola, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5111-14

5111-5114

2159

697

50.

OPTIMIZATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE THEOCLATE WITH EFFERVESCENT TECHNOLOGY USING 32 FULL FACTORIAL DESIGN

The aim of the research work was to develop and optimize fast dissolving tablets of Promethazine Thecolate by direct compression using effervescent technology. For the investigation, purpose a 32 full factorial design was used to know the joint influence of two formulation variables, Crospovidone and Citric acid. The formulated tablets were evaluated for its percent friability and their disintegra...

S. Hardenia *, G. N. Darwhekar and R. P. Singh

SGVU, Department of pharmaceutics, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5115-24

5115-5124

1693

390

52.

IN VITRO ANTICANCER ACTIVITY OF BIOPHYTUM SENSITIVUM WHOLE PLANT EXTRACTS AGAINST CERVICAL AND LIVER CANCER CELL LINES

In the present study, the various extracts viz aqueous, ethanol, chloroform and Petroleum ether of Biophytum sensitivum whole plant were evaluated for the anticancer activity against cancer cell lines. The cervical (Hela) and liver cancer (HepG2) cell lines were used to screen the in vitro anticancer challenging with the B.sensitivum extracts. Concentration ranges from 20 to 100 microgram of B.s c...

M. P. Shanthi, G. Bupesh * , S. Magesh, K. Meenakurmari, K. Saravanan and N.S. Muthiah

Central Research Laboratory, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, Biher, Chrompet, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(12).5128-35

5128-5135

2586

575