Volume 2 (2011) - Issue 11, November
Review Articles
LIPID PEROXIDATION: AN OVERVIEW
Lipid peroxidation (LPO) in cellular membranes is associated with changes in physicochemical properties and impairment of protein functions located in membrane environment. Recent studies shows involvement of LPO in biological signaling and various diseases. Lipids are oxidized by three distinct mechanisms: enzymatic oxidation; non-enzymatic, free radical-mediated oxidation and non-enzymatic, non ...
4595
1250
SUPERDISINTEGRANTS IN THE DEVELOPMENT OF ORALLY DISINTEGRATING TABLETS: A REVIEW
The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. The field has become a rapidly growing area in the pharmaceutical industry and ga...
28001
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BIOSYNTHESIS OF NANOPARTICLES
Biosynthesis of nanoparticles is reviewed in detail in this study. Comparison of different synthesis methods, namely physical, chemical and green methods giving emphasis to biological synthesis is documented here. This study also details limitations of the present techniques and envisages the future scope of nanoparticle biosynthesis. Important applications of nanoparticles are also discussed brie...
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Research Articles
IN-VITRO STUDIES OF ANTIBACTERIAL AND CYTOTOXIC PROPERTIES OF FLACOURTIA JANGOMAS
The Plant Flacourtia jangomas have shown considerable antibacterial and cytotoxicity properties. The extracts were found to have different levels of cytotoxicity properties in different concentration. The crude extract of the plant Flacourtia jangomas was subjected to in vitro microbiological screening for studying anti-microbial activity of the extract against a wide of Gram-positive and Gram- ne...
3767
1265
ANTIOXIDANT, ANALGESIC AND CYTOTOXIC ACTIVITIES OF MIMUSOPS ELENGI LINN. LEAVES
Mimusops elengi Linn. (Family: Sapotaceae) is a tree which is traditionally used against a number of diseases including ulcers, headache, dental diseases, wound and fever. In the present study crude methanolic extract of Mimusops elengi Linn. leaf was investigated for possible antioxidant, analgesic and cytotoxic activity. The extract exhibited statistically significant antioxidant activity in DPP...
3079
1036
SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF TRAZODONE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
Spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These method based on the formation of chloroform soluble ion-association complexes of TRH with bromphenol blue (BPB) and with chlorophenol red (CPR) in buffer of pH 2.0 (for BPB) and buffer of pH of 4 (for CPR) with absorption maximum at 420 nm and at 410 nm for B...
3399
1348
PREPARATION AND EVALUATION OF HPMC-ALGINATE MUCOADHESIVE MICROCAPSULES OF DICLOFENAC FOR CONTROLLED RELEASE
A new, novel promising technology for obtaining controlled release and enhancing the bioavailability is a combination of mucoadhesion principle and microencapsulation to result in mucoadhesive microcapsules. Mucoadhesive microcapsules consist of either entirely of a mucoadhesive polymer or having an outer coating enclosing the drug particles. They facilitate an intimate and prolonged contact with ...
2952
1095
DESIGN, DEVELOPMENT AND EVALUATION OF MATRIX TABLET CONTAINING INDIGENOUS MEDICINAL PLANTS
A Sustained release tablet formulation should ideally have a proper release profile that is usually encountered in manufacturing. The objective of the present investigation was to develop the sustained release matrix tablet of Boswellia serrata, Moringa oleifera and Vitex negundo using the combination of hydrophilic and hydrophobic polymers.Tablet formulations were developed using wet granulation ...
3378
2152
PHARMACOGNOSTICAL INVESTIGATIONS ON IPOMOEA AQUATICA FORSK.
Plants are a great source of medicines, which are useful in the treatment of various diseases. Ipomoea aquatica Forsk of family Convolvulaceae commonly known as Kalmisag or Nalanibhaji is being used as a green leafy vegetable and have great medicinal value in Indian medicine. It is used in Unani System of Medicine as carminative, lessens inflammation, useful in fever, jaundice, biliousness, bronch...
4288
1675
STUDIES ON PHYTOCHEMICAL AND VITAMIN ANALYSIS OF PLEUROTUS PLATYPUS AND PLEUROTUS OEUS BY GC-MS AND HPLC TECHNIQUE
In this study, Pleurotus platypus and Pleurotus eous was subjected to identification of bioactive compounds by using Gas chromatography – Mass spectrum technique. These two organisms were extracted with 99% of ethanol. Extracted sample was injected, according to the retention time and peak formation the bioactive compounds are screened. In Pleurotus platypus Pyridine-3-carboxamide, 4-dimethylami...
3094
1193
COMPARISON OF CHEMICAL COMPOSITION OF THE ESSENTIAL OIL OF HYPTIS SUAVEOLENS (L.) POIT LEAVES FROM DIFFERENT REGIONS OF TAMIL NADU
The chemical composition of the essential oil of Hyptis suaveolens (L.) leaves from three different regions of Tamil Nadu was analysed by GC – MS method and the constituents of three different localities were compared. In all 12 compounds were identified and they were α-caryophyllene, α-pinene, α-thujene, camphene, D-limonene, sabinene, β-myrcene, 1, 8-cineole, γ-terpinene, α-terpinolene, ...
3404
1133
PLANT REGENERATION FROM THE NODAL PART OF CITRULLUS COLOCYNTHIS (L.) SCHARD.
Citrullus colocynthis, belonging to the family of cucurbitaceae. It is a xerophytic desert plant, widely used for its medicinal purpose. In tribal areas it is used for the treatment of constipation, oedema, bacterial infection, cancer, diabetes and abortifacient. Present study is based on developing a protocol for plantlet regeneration from the nodal segment. The sterilized explants were inoculate...
2738
1066
DETERMINATION OF THE CONCENTRATION BLENDS OF SUPERDISINTEGRANT FOR FAST DISINTEGRATING TABLETS
In this research work, different blends of superdisintegrants with different ratio in fixed concentration were taken and placebo tablets were formulated and evaluated with a view to optimize a formula and concentration blends of superdisintegrants for Fast Disintegrating Tablets (FDT). In this research work three superdisintegrants, viz. Crosscarmellose, Crospovidone and Sodium Starch Glycolate we...
3518
1151
HYPOLIPEDEMIC EFFECT OF CYNODON DACTYLON ON HISTOPATHOLOGICAL STUDY AND DNA FRAGMENTATION ANALYSIS IN EXPERIMENTALLY INDUCED HYPERCHOLESTEREMIC RATS
Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Cynodon dactylon (Bermuda grass) on histopathological study and DNA fragmentation analysis in experimentally induced hypercholesteremic rats. Four groups of rats were employed namely control, hypercholesterolemia rats (4% Cholesterol＋1% cholic acid)...
2650
1021
EFFECT OF PERMEATION ENHANCER ON EX-VIVO PERMEATION OF ONDANSETRON HCl BUCCAL TABLETS
The objective of the paper is to study the effect of a permeation enhancer, sodium taurocholate on permeation of Ondansetron HCl from bioadhesive buccal tablet formulation by performing ex-vivo permeation experiments using porcine buccal mucosa. Optimized formulation has selected based on in-vitro drug release studies of bilayered bioadhesive buccal tablets. To the optimized formulation, 10mM sodi...
3489
1244
PREVALENCE & ANTIBACTERIAL RESISTANCE OF ESBLs AMONG PREGNANT WOMEN WITH UTI
Urinary tract infection (UTI) remains the common infections diagnosed in outpatients as well as in hospitalized patients. Worldwide data show that there is an increasing resistance among urinary tract pathogens to conventional drugs. Extended spectrum beta lactamases (ESBL) hydrolyse expanded spectrum cephalosporins like ceftazidime, cephotaxime which are used in the treatment of UTI. ESBL-pro...
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1030
DETERMINATION OF TOLTERODINE TARTRATE IN PHARMACEUTICAL PREPARATIONS USING EOSIN, APPLICATION TO STABILITY STUDY
Spectrophotometric method has been developed for the determination of Tolterodine tartrate (TOL) which is based on formation of a binary complex between TOL and eosin at 545 nm using acetate buffer at pH 3.8.The absorbance-concentration plot is rectilinear over the range (1-10μg/ml) with LOD of 0.1μg/ml and LOQ of 0.31μg/ml. The proposed method was successfully applied to the analysis of commer...
3207
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PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF STEM OF CISSUS QUADRANGULARIS L.
The stems of Cissus quadrangularis L. (Vitaceae) are reported to have great medicinal value. The present investigation was therefore undertaken to determine the requisite pharmacognostic standards for evaluating the plant material. The macroscopic features of the Cissus quadrangularis L. stem were observed under magnifying lens. Microscopic characters and powder analysis were determined under micr...
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DISCRIMINATORY DISSOLUTION METHOD DEVELOPMENT AND VALIDATION FOR CEPHALEXIN OD TABLETS
In this study, a discriminative dissolution method was developed for Cephalexin OD (orally disintegrating) tablets 750mg. The solubility and stability of the cephalexin API was determined in ten different solutions. In that 0.01N HCl, glycine buffer pH 3-0, acetate buffer pH 4.5 and water gave good stability and the solubility. Dissolution profiling of cephalexin OD tablets 750mg of single batch w...
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PROTEIN OXIDATION AND ANTIOXIDANT VITAMINS IN LEPROSY
Aims The presence of carbonyl groups in proteins has been used as a marker of ROS-mediated protein oxidation. The present work was undertaken to study the importance of endogenous antioxidants like Vitamin C and vitamin E in different types of leprosy patients. Methods: Total 30 leprosy cases were studied. Patients were subjected to various   tests like, serum protein carbonyl as an index o...
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1302
EVALUATION OF CNS DEPRESSANT AND ANALGESIC ACTIVITIES OF THE METHANOL EXTRACT OF PIPER LONGUM LINN. LEAVES
Present study reports CNS depressant and analgesic activities of methanol extract obtained from the leaves of Piper longum L (MEPL). CNS depressant activity was evaluated by using open field and hole cross tests at doses of 250 and 500 mg/kg body weight while peripheral analgesic activity was evaluated by using acetic acid induced writhing method and formalin test respectively in rat model at 100 ...
3151
1046
CHARACTERISATION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES FROM SHINGLES PATIENTS
Even after treating Shingles patients with antiviral drugs, they are found to suffer from secondary bacterial infections. With this background as a guide, we undertook an investigation to isolate the bacterial pathogens from the pus of Shingles patients. Among the isolates obtained during the one year study period, Staphylococcus aureus sp. was found to be multi drug resistant and hence it was cho...
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875
INHIBITION KINETICS OF E. COLI BY METHANOLIC ROOT EXTRACT OF ALSTONIA SCHOLARIS
The potential of methanol extract as a potent antimicrobial agent has been observed to be an effective means to combat disease causing pathogenic organisms. Growth pattern of Escherichia coli cells showed that the growth of cells decreased with an increase in concentration of extract. The specific relationship between the specific growth rate and the substrate concentration was thus be obtained by...
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POTENTIAL ANTIBACTERIAL AND ANTINFUNGAL ACTIVITY OF AQUEOUS EXTRACT OF CYNODON DACTYLON
The use of medicinal plants in the world and especially in India, contributes significantly to primary health care. Whole plant of the Cynodon dactylon is traditionally used to treat painful and inflammatory condition. We have undertaken this study since no detailed scientific study was available regarding the antifungal and antibacterial activity of the aqueous extract of the whole plant.  In ...
6405
1990
COMPARISON OF HPLC AND HPTLC TECHNIQUES FOR DETERMINATION OF UMBELLIFERONE FROM DRIED TUBER POWDER OF IPOMOEA MAURITIANA JACQ.
Umbelliferone is a widely occurring phenolic compound of plant origin, for which many biological activities against chronic diseases have been reported. A comparative study of HPLC and HPTLC method has been developed for the quantitation of umbelliferone from dry tuber powder of Ipomoea mauritiana Jacq. Both the methods were validated for linearity, precision, limit of detection (LOD), limit of qu...
3161
1507
EFFECT OF FORMULATION VARIABLES ON THE RELEASE OF ACECLOFENAC FROM HPMC MATRIX TABLETS
The objective of this work was to study the effect of concentration and viscosity grade of HPMC, different diluents and inclusion of solid dispersions on the matrix tablets of aceclofenac. In present study, aceclofenac, a novel NSAID used for symptomatic treatment of pain and inflammation was formulated into matrix tablets with HPMC of two different viscosity grades (E50 LV and K15 M) by direct co...
3001
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ANALYSIS OF FIXED OIL FROM STERCULIA FOETIDA LINN.
Analysis of fatty acid composition in fixed oil extracted from Sterculia foetida Linn. (Sterculiaceae) seed was done with the help of GC-MS. The structural identification was done by preparing FAME of the fixed oil and then subjected to GC-MS wherein Flame Ionization Detector was used. The oil constituted of 7 fatty acids whose carbon chain length, degree and position of unsaturation were determin...
5294
1896
ANTI-INFLAMMATORY, ANTI-ARTHRITIC AND ANALGESIC ACTIVITY OF THE ALCOHOLIC EXTRACT OF THE PLANT URGINEA INDICA KUNTH.
This study was designed to present the observation of the pharmacological properties to the bulb of the plant. The extract of the bulb of Urginea indica Kunth were collected by using of alcoholic extraction. The anti-inflammatory action of the alcoholic Extract of the bulb of the plant Urginea indica was evaluated in rats (female) against carrageenan induced edema i.e., using plethysmographic meth...
3290
1211
ANTIOXIDANT POTENTIAL OF THE WHOLE PLANT EXTRACT OF MOLLUGO PENTAPHYLLA LINN. ON ETHANOL INDUCED LIVER DAMAGE
The potential antioxidant effect ethanol induced liver damage was investigated using crude methanolic extract of the whole plant of Mollugo pentaphylla  Linn. The standard drug used was ascorbic acid mg / kg/day. Serum cholesterol, triglycerides aspartate amino transferase (AST) and alanine amino transferase (ALT) levels were measured as antioxidant indicators. There was a significant reduction...
2747
1069
CHOLESTEROL ESTERASE ENZYME INHIBITORY AND ANTIOXIDANT ACTIVITIES OF LEAVES OF CAMELLIA SINENSIS (L.) KUNTZE. USING IN VITRO MODELS
The present study was to evaluate the in vitro cholesterol esterase enzyme inhibitory and in vitro antioxidant activity of the methanol extract of the leaves of Camellia sinensis (L.). Phytochemical screening of the extract shows the presence of flavonoids, phenolics and terpenoids. The extract shows ability to inhibit the enzyme with IC50 (82.46±0.74µg/ml) where as that of standard, Orlista...
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1342
FORMULATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM (FLOATING TABLETS) OF NIFEDIPINE
Among novel drug delivery systems, rate controlled oral drug delivery system forms an important area. Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times and unpredictable gastric emptying times. Several approaches are currently utilized in the prolongat...
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2124
HYPOGLYCEMIC EFFECT OF ACALYPHA INDICA LINN. PLANT EXTRACTS ON STREPTOZOTOCIN INDUCED DIABETES IN RAT
The plant Acalypha indica Linn. is commonly known as Indian Acalypha and it belongs to the family Euphorbiaceae, found in all parts of the tropics. This herbs found in fields and wastes places throughout the hotter parts of the world. The plant has wide uses in the traditional  medicines of  various countries and reportedly possesses diuretic, purgative and anthelmintic properties, b...
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EVALUATION OF ANTIULCER ACTIVITY OF CALOTROPIS GIGANTEA R.Br LEAVES
The antiulcer activity of ethanolic extract of Calotropis gigantea R.Br leaves (EECG) was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Ethanolic extract of Calotropis gigantea at a dose of 150 and 300mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation indu...
3394
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IN- SILICO ANALYSIS OF MOST SUITABLE DRUG FOR PATHOGENIC BACTERIA CAUSING PERIODONTITIS
The human oral cavity is a complex biological system in which members of a microbial community interact with themselves as well as with different host structures and components Neisseria sp., Haemophilus influenzae and Campylobacter jejuni cause periodontitis . The pathogenesis of this dental infection is a multi factorial process that results in a serious degenerative disease of the periodontiu...
3270
1124
SYNTHESIS, CHARACTERIZATION AND NUCLEASE ACTIVITY OF AU (III) – COMPLEXES OF BIACETYL MONOXIME THIOSEMICARBAZONE (BAMOT) AND SUBSTITUTED THIOSEMICARBAZONES
Metal complexes of Au(III) with Thiosemicarbazone and Substituted Thiosemicarbazones different thiosemicarbazones have been synthesized. The present communication reports the structural study of the Au(III) complexes with Biacetyl Monoxime Thiosemicarbazones and these complexes have been characterized by elemental analysis, conductance, IR, NMR and Mass spectral data. The physicochemical and spe...
2609
1157
HISTOCHEMICAL AND PHYTOCHEMICAL MARKERS FOR THE AUTHENTICATION OF AYURVEDIC RAW DRUG HALLAKAM (KAEMPFERIA ROTUNDA) AND ITS MARKETED ADULTERANT
Comparative pharmacognostic and phytochemical studies are the reliable source to identify the genuine raw drug from its adulterants. This paper deals with the characterization of the repute ayurvedic drug hallakam from its substitute/adulterants. Ayurvedic experts equated rhizomes of Kaempferia rotunda L. of Zingiberaceae as hallakam and in certain market samples Lagenandra toxicaria Dalz. is also...
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1626
SYNTHESIS AND IN- VITRO ANTIOXIDANT ACTIVITY OF SOME NEW 2, 5-DISUBSTITUTED-1, 3, 4-OXADIAZOLES CONTAINING FURAN MOIETY
A series of five membered heterocyclics was synthesized by the reaction between refluxing 2 - furoic acid with ethanol and conc. H2SO4. The obtained ester (2) with hydrazine hydrate and ethanol was refluxed to give hydrazides (3). Reaction of hydrazides (3) with different aromatic acids using phosphorousoxy trichloride (POCl3) lead to the formation of 2-Aryl -5-furyl -1, 3, 4-oxadiazoles [DM (1-...
3050
1566
IN-VITRO SENSITIVITY OF AMPHOTERICIN B, ITRACONAZOLE AND FLUCONAZOLE – RESISTANT AGAINST CANDIDA ALBICANS
Aim: To study In-Vitro sensitivity of Amphotericin B, Itraconazole and Fluconazole -Resistant against Candida albicans. Methods and Results:Â A panel of 14 clinical isolates of Candida albicans was tested. Strains were labeled and given a unique identification number. Candida albicans ITCC 4718 were included as quality control organisms in each set of experiments. Interactions in vitro between...
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FORMULATION AND EVALUATION OF MATRIX MICROSPHERES FOR SIMULTANEOUS DELIVERY OF CANDESARTAN CILEXETIL AND CAPTOPRIL FOR TREATMENT OF NEPHRITIC SYNDROME
The objective of the present study was to prepare and evaluate matrix microspheres system for simultaneous and sustained release of candesartan cilexetil and captopril for the management of nephritic syndrome, Ethyl cellulose was used as a retardant polymer and IR study showed better compatibility of it with both the drugs, the matrix microspheres were prepared by emulsion solvent evaporation me...
3132
1931
SOLID LIPID NANOPARTICLES FOR ENHANCEMENT OF ORAL BIOAVILABILITY OF CEFPODOXIME PROXETIL
Solid lipid nanoparticles (SLNs) have been proposed as suitable colloidal carriers for delivery of drugs with poor bioavailability. The objective of this study was to develop and evaluate solid lipid nanoparticles of Cefpodoxime Proxetil (CP) for enhancement of bioavailability via its lymphatic absorption. Solvent evaporation technique was adopted to prepare Cefpodoxime Proxetil loaded SLN with Pr...
3515
1412
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF NAPROXEN SODIUM
Naproxen sodium is an analgesic NSAID (non steroidal anti inflammatory drug) used for the treatment of pain, inflammation, fever and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout, migraine and dysmenorrhea. However, the gastric discomfort caused by drug results in poor patient compliance associated with its conventional dosage forms. Hence th...
4214
1470
ANTIBACTERIAL EVALUATION, REDUCING POWER ASSAY AND PHYTOCHEMICAL SCREENING OF MORINGA OLEIFERA LEAF EXTRACTS: EFFECT OF SOLVENT POLARITY
Moringa preparations have been cited in the scientific literature as having antibiotic, antitrypanosomal, hypotensive, and antispasmodic, antiulcer, anti-inflammatory, hypo-cholesterolemic, and hypoglycemic activities, as well as having considerable efficacy in water purification by flocculation, sedimentation, antibiosis. To evaluate the antioxidant activity of Moringa oleifera leaf extracts an...
3884
1689
FIRST DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE HYDROCHLORIDE AND OLANZAPINE IN TABLETS
Fluoxetine hydrochloride (FH) in combination with Olanzapine (OZ) is used in treatment of depressive episodes associated with bipolar disorder. The first derivative spectrophotometric method for simultaneous determination of fluoxetine hydrochloride (FH) and olanzapine (OZ) from two component tablet dosage form has been developed and validated. Chromatographic methods viz. HPLC and HPTLC methods...
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PRIMARY FALLOPIAN TUBE ADENOCARCINOMA: A CASE REPORT
Purpose: Primary fallopian tube carcinoma (PFTC) is a rare tumor that histologically and clinically resembles to epithelial ovarian cancer (EOC). The purpose of this study is to present a case history, treatment & review the current available literature on PFTC. Material, methods and results: Early clinical presentation and prompt investigation often lead to diagnosis at an early stage. The...
2786
1011
DMSO INDUCED PRODUCT RECOVERY OF BACOSIDE A IN CELL SUSPENSION CULTURE OF BACOPA MONNIERI LINN.
Bacopa monnieri Linn. is an important medicinal plant belonging to family scrophulariaceae. Bacopa is a neurotonic, immuno-modulator, tranquilizing, memory and learning enhancing, cerebral activator, anti-ulcer, antispasmodic, anti-asthmatic. It is also used in Epilepsy, anxiety and depression. Major component of Bacopa are saponins Bacoside A and Bacoside B. The cell suspension culture of BacopaÂ...
3036
1099
AN ETHANOLIC EXTRACT FROM LICORICE (GLYCYRRHIZA GLABRA) EXHIBITS ANTI-OBESITY EFFECTS BY DECREASING DIETARY FAT ABSORPTION IN A HIGH FAT DIET-INDUCED OBESITY RAT MODEL
The present study was to investigate the anti-obesity effects of the freeze dried powder of ethanolic extract of Licorice (Glycyrrhiza Glabra) (LP) in a rat model of high-fat diet induced obesity and hyperlipidemia. Male wistar rats were fed with a high-fat diet for 8 weeks to induce obesity and hyperlipidemia. High fat diet induced obese rats exhibited increases in body weight gain, adipose tissu...
5868
1601
PHARMACOGNOSTICAL, PHYTOCHEMICAL AND CARDIOPROTECTIVE ACTIVITY OF TAMARINDS INDICA LINN. BARK
Many herbal remedies have been employed in various medicine systems for the treatment and management of the different diseases. The Tamarinds indica commonly known as ‘imali’ has been recognized in different system of traditional medicines for the treatment of different diseases and aliments of human being. This review supports of all updated information on its pharmacognostical, pharmacologic...
4662
1376
ANTIHYPERLIPIDEMIC EFFECT OF REOSTO, A HERBOMINERAL FORMULATION IN TRITON INDUCED HYPERLIPIDAEMIC RATS
In the present study, an aqueous extract from a marketed mineralo-herbal preparation Reosto was evaluated for its hypocholesterolaemic and hypertriglyceridemic activities using Triton WR-1339 induced hyper- lipidemic rats as experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton (200 mg/kg body weight). The animals were divided into control (CG), hyperlipidemic (HG...
2774
1153
POLYETHYLENE GLYCOL (PEG) SUPPORTED AMINO DENDRIMERS (DENDRITIC TRIBLOCK COPOLYMER) FOR DELIVERY OF METHOTREXATE (MTX)
Dendrimers are synthetic, highly branched, nanosized, monodisperse macromolecule which proving their applicability in different areas like diagnosis, drug delivery, gene delivery, molecular encapsulation etc. Due to their widespread applications, scientific community is continually engaged in developing newer dendrimers with advanced properties. In the present study, amino dendrimers are synthesiz...
2705
984
STUDY OF RELEASE KINETICS OF DEXAMETHASONE FROM BIODEGRADABLE PLGA IN-SITU IMPLANTS
The primary objective of this study is to evaluate the effect of drug loading and the effect of excipients on the release pattern of Dexamethasone Sodium Phosphate from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in dimethyl sulfoxide (DMSO). Then the drug with excipients or without excipients was added to it. Wh...
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