Volume 7 (2016) - Issue 12, December
Review Articles
A REVIEW ON ETHNOPHARMACOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGY OF BUDDLEJA ASIATICA
Buddleja asiatica commonly called as butterfly bush is a tender deciduous plant. It is endemic to Asia and found in most parts of India. Traditionally it is used in the treatment of many health disorders such as inflammation, rheumatism, skin disease, malaria etc. In view of pharmacological aspect, Buddleja asiatica is screened for antihepatotoxic, antibacterial, hypotensive, anticancer, antifunga...
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SALVIA GENUS AND TRITERPENOIDS
Salvia L., is one of the largest genera from Lamiaceae (Labiatae) family which comprises 900 species and is widely distributed in various regions of the world like in America, Europe, Asia. In this review article, the triterpenoid constituents were investigated from all of the Salvia plants to date are reported. About 214 triterpenoids of different classes were isolated and characterized from 113 ...
5797
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EMULGEL-NOVEL TOPICAL DRUG DELIVERY SYSTEM–A COMPREHENSIVE REVIEW
Emulgel systems are currently of attention to the pharmaceutical scientists because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules. These are either emulsion of water in oil type or oil in water, which is gelled by mixing it with a gelling agent. Incorporation of emulsion into gel makes it a dual control release system & also inc...
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AYURVEDIC NATURAL EXCIPIENTS: AN ADVANCE OPTION FOR MODERN MEDICAMENTS
Excipients are important partner in formulation that decide dosage form as well as Pharmacokinetics and pharmacodynamics of medicament. In contemporary era, excipients are used from synthetic resources, causes unwanted effect in pharmaceutics and therapeutics. So industries are looking towards natural resources as it delivers safe, biodegradable, cost effective, biocompatible and inert excipient t...
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KAWASAKI SYNDROME- A REVIEW
Aim: The aim of this review is to provide a detailed documentation and main features such as prevalance, manifestations and management regarding Kawasaki syndrome. Background: Kawasaki Syndrome was first described by Dr Tomisaku Kawasaki in Japan in 1967, since then prevalence of Kawasaki syndrome is increasing in all countries as per the reports in journals. This is more prevalent in Asian pacifi...
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Research Articles
THE IMPACT OF ADENOSINE A2B RECEPTORS MODULATION ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA CO-ACTIVATOR 1-ALPHA AND TRANSCRIPTION FACTORS
Previous studies have demonstrated that the activation of adenosine A2B receptors increases adenosine 3'-cyclic monophosphate (cAMP) accumulation in rat skeletal muscle cells, which is probably an important yet unknown mechanism contributing to the regulation of skeletal muscle functions. via rat L6 skeletal muscle cells, it has been elucidated further potential molecular signaling responsible for...
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REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ESTIMATION OF BIOACTIVE COMPOUNDS FROM DIFFERENT FRACTIONS OF NEW POLYHERBAL FORMULATION OF CLINACANTHUS NUTANS AND ELEPHANTOPUS SCABER
Background: Polyherbal formulation is the trend of modern pharmacognosy and holistic approach in the treatment of uncurable diseases such as cancer. Medicinal plants contain many bioactive compounds that give different pharmacological activities. Therefore, it is important to investigate the quality of new polyherbal formulation by identification of bioactive markers. Objective: To identify apig...
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1608
GRAPE SEED EXTRACTED (VITISVINIFERA) ALLEVIATE HEPATIC TOXICITY INDUCED BY THE ANTI-OESTROGEN TAMOXIFEN IN FEMALE ALBINO RATS
Aim: The present study has been undertaken to investigate the therapeutic effect of GSE (Grape seed extracts) against Tamoxifen (TAM), induced hepatotoxicity in rat. Methods: The rats were divided into four groups • Group 1: rats were injected intraperitoneally (i.p.) with saline for seven days. • Group 2: Rats were treated with TAM in a dose of 45 mg/kg b·w/day, i.p., for seven successive da...
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INVESTIGATION OF HEAVY METALS CONTENT IN SELECTED TEA BRANDS MARKETED IN PODGORICA, MONTENEGRO
Medicinal plants are sources of different chemical substances with different biological activities in living organism. Some of the chemical compounds so-called “heavy metals”, can be dangerous because they tend to bioaccumulate and transported in all biota via the food chain. The aim of our study was to investigate the concentration of heavy metals in commercially available tea samples purchas...
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EFFICACY OF SECURIDACA LONGEPEDUNCULATA ON THE PARAMETERS OF BLOOD GLUCOSE LEVEL AND PULSE RATE OF ENVENOMED ALBINO RATS
The study was undertaken to investigate the in vivo activity of aqueous and ethanol extracts of Violet plant, Securideca longepedunculata leaves and root bark against snake venom of Naja nigricollis and blood glucose level along with pulse rate in experimental albino rats. Healthy adult albino rats weighing 250-300g were used and randomly divided into five groups for in vivo anti-snake venom activ...
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ANTIDIABETIC AND HAEMATOLOGICAL EFFECT OF MYRIANTHUS ARBOREUS P. BEAUV. STEM BARK EXTRACT IN STREPTOZOTOCIN – INDUCED DIABETIC RATS
The increasing prevalence of diabetes mellitus worldwide is an issue of major socio-economic concern especially in Sub - Saharan Africa. Indigenous medicinal plants are used for the treatment of diabetes mellitus in most developing countries, like Ghana, but remain to be validated. In the present study, the effect of Myrianthus arboreus ethanol stem bark extract (MAB) (100 - 400 mg/kg) on glucose ...
3990
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THE EFFECT OF NECA, CGS 21680, PSB 603 ON FATTY ACID TRANSPORT AND OXIDATION IN SKELETAL MUSCLE CELLS
Adenosine is a strong modulator of gene expression, which underpins some of its potential expected effects in skeletal muscle in terms of fatty acid metabolism. Accumulating evidence highlights a critical role for the adenosine system in the regulation of fatty acid metabolism and obesity. However, its molecular signaling role in fatty acid transport and oxidation in skeletal muscle is less clea...
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EXTENT OF PHOTO-DEGRADATION OF THREE DIFFERENT DIAZEPAM TABLET FORMULATIONS AVAILABLE IN TRANSPARENT PACKAGING: AN UV ANALYSIS
This study was designed to determine the extent of photolytic degradation of diazepam tablets, without light-protective packaging, available in the market. The UV spectroscopy method was designed and applied for this purpose. A total of 2160 tablets (each tablet contained 5 mg diazepam) of three different brand formulations A, B and C were chosen randomly. These tablets were then exposed to differ...
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ASSOCIATION OF THE APOLIPOPROTEIN B/APOLIPOPROTEIN A-1 RATIO WITH THE SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Although many studies have demonstrated the importance of the apoB/apoA-1 ratio as a risk marker of atherogenicity, less is known about apoB/apoA-1 ratio in predicting and the severity of coronary artery disease (CAD) in T2DM. Our study aimed to assess possible associations between apoB/apoA-1 ratio levels and the severity of coronary artery diseases in patients with type 2 diabetes mellitus (T2DM...
3186
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ORAL DELIVERY OF ROSUVASTATIN LIPID NANOCARRIERS: INVESTIGATION OF IN VITRO ANDIN VIVO PROFILE
Present study is a systematic approach to provide ‘proof of concept’ for effective oral delivery of Rosuvastatin lipid nanocarriers for treatment of hyperlipidemia. Rosuvastatin is a ‘Superstatin’ belonging to BCS class II having low bioavailability (20%). Development of lipid nanocarriers for oral delivery of rosuvastatin can be beneficial in enhancing bioavailability and providing sustai...
4021
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Prevalence and Co-infection of Cosavirus in Pediatric Patients with Acute Gastroenteritis from North India
Viral gastroenteritis is one of the major causes of childhood mortality in India. About 30 to 50 % gastroenteritis caused by unknown etiological agents. This study was aimed to identify unknown RNA viral etiology and their clinical manifestation with pediatric acute gastroenteritis, conducted at tertiary care hospital of Uttar Pradesh, North India from July 2012 to December 2013. A total of 234 pa...
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UV ANALYSIS OF THE EXTENT OF PHOTO-DEGRADATION OF THREE DIFFERENT DIAZEPAM TABLET FORMULATIONS UNDER DIFFERENT LIGHT EXPOSURES
This study was designed to determine the extent of photolytic degradation of diazepam tablets, without light-protective packaging, available in the market. The UV spectroscopy method was designed and applied for this purpose. A total of 2160 tablets (each tablet contained 5 mg diazepam) of three different brand formulations A, B and C were chosen randomly. These tablets were then exposed to differ...
2974
1024
FORMULATION DEVELOPMENT AND SOLUBILITY ENHANCEMENT OF ROSUVASTATIN CALCIUM TABLET PREPARED BY COMPLEXATION WITH β-CYCLODEXTRIN BY KNEADING METHOD
Rosuvastatin is a Dyslipidaemic agent, which acts by inhibiting HMG-CoA reductase enzyme and used in the treatment of hyperlipidemia. But Rosuvastatin calcium (RST) exhibit unsatisfactory dissolution profiles, problems of absorption and poor bioavailability. Thus objective of the study is to increase the solubility and dissolution rate of Rosuvastatin calcium (RST), a poorly water-soluble 3-hydrox...
10021
1975
STUDIES ON ISOLATION, PURIFICATION AND STRUCTURE ELUCIDATION OF CHEMICAL CONSTITUENTS FROM METHANOLIC FLOWER EXTRACT OF BLEPHARIS MOLLUGINIFOLIA PERS. AND THEIR BIOLOGICAL ACTIVITIES
Blepharis molluginifolia (Acanthaceae), is a threatened medicinal herb. The methanolic flower extract of Blepharis molluginifolia was subjected to Silica Gel Column Chromatography for purification of bioactive compounds and structure elucidation of active compounds were studied. DPPH and antimicrobial activities of two isolated compounds were studied. From the analysed data, the compounds identifi...
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MOLECULAR CHARACTERIZATION OF PSEUDOMONAS AERUGINOSA ISOLATES RECOVERED FROM HUMAN PATIENTS IN HIMACHAL PRADESH (INDIA) FOR SELECTIVE GENES: EXTENDED SPECTRUM β-LACTAMASE (ESBL), AMPICILLIN CLASS C (AMPC) AND METALLO β-LACTAMASE (MBL) GENES
The present study highlights the occurrence of β-lactamase (bla) genes belonging to different classes: extended spectrum β-lactamase genes (blaTEM, blaSHV, blaCTX-M and blaPER), metallo β-lactamase genes (blaNDM and blaGIM and Ampicillin class C genes (blaPDC and blaCMY) in P. aeruginosa isolates by PCR amplification. The isolates were recovered from human patients of Indira Gandhi Medical Coll...
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THE IMPACT OF ADENOSINE A2B RECEPTORS ON GLYCOLYSIS AND INSULIN RESISTANCE IN SKELETAL MUSCLE
Adenosine has been proposed as a key factor regulating the metabolic balance between energy supply and demand in skeletal muscle. Adenosine A2B receptors are expressed across multiple tissues including skeletal muscle. Previously, it has been identified the robust (in vitro) induction of the nuclear receptors (NR4A) subgroup following adenosine A2B receptors stimulation in rat skeletal muscle cell...
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COMPARING GREEN CHEMICAL METHODS AND CHEMICAL METHODS FOR THE SYNTHESIS OF TITANIUM DIOXIDE NANOPARTICLES
Metal nanoparticles are usually synthesized using various chemical methods such as chemical reduction, Solvo-thermal reduction, electrochemical techniques and photochemical reaction in reverse micelles. All these methods are divided into two categories chemical and green chemical. Each having certain advantages and disadvantages. In this study we have tried to give a few examples of these methods ...
10532
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EFFICACY OF NON POLAR EXTRACT (NPE) OF ALOE BARBADENSIS MILL. IN POLYCYSTIC OVARIAN SYNDROME (PCOS) RODENT MODEL- AN “IN VIVO” STUDY
Aim of the current study was to evaluate the efficacy of non polar extract (NPE) of Aloe vera gel (AVG) for 60 days (~25μg/daily/orally) in rodent model of polycystic ovarian syndrome (PCOS). After treatment, steroid hormones and insulin levels were estimated by ELISA, serum lipid profile along with ovarian steroidal enzyme activity. Also, transcript as well as protein level of key receptors and ...
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ALLIUM SATIVUM REGULATES LIPID METABOLISM IN ALLOXAN INDUCED DIABETIC RATS
Allium sativum (A. sativum), commonly known as garlic, is a species in the onion genus, Allium. The hypolipidemic activity of A. Sativum (Family: Amaryllidaceae) extract have been studied in alloxan-induced diabetic rats. In this model oral administration of extract (500mg/kg bw., p.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal ...
2996
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DIAGNOSIS OF NON-POLIO ENTEROVIRAL INFECTIONS IN SEPTIC NEONATES BY POLYMERASE CHAIN REACTION ASSAYS
Objective: The purpose of this study was to investigate the prevalence of non-polio enteroviral infections by quantitative and qualitative PCR assays in neonates 3-30 days old with clinical diagnosis of sepsis. Methods: The patients included all the neonates aged 3-30 days admitted with diagnosis of neonatal sepsis. Blood specimens, throat swabs, and in 60 cases CSF specimens were tested for Enter...
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6-OXA-3-THIAOCTANOIC ACID HAS POTENTIAL INHIBITORS AGAINST THYROID CANCER- IN-SILICO ANALYSIS
Cancer is an uncontrollable incurable disease with abnormal growth and proliferation of cells. Thyroid cancer is caused due to the thyroid hormone effects on growth, development and homeostasis in mammals. Thyroid cancer is the most common endocrine malignancy. Thyroid hormone is encoded by two types of thyroid receptors that are TRα and TRβ. TRα is functionally divided in two types TRα1 and T...
3933
1016
DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR ESTIMATION OF MEPHENESIN AND IBUPROFEN
A new RP-HPLC method was developed for Mephenesin (MEP) and Ibuprofen (IBU) and validated as per ICH guidelines. Good chromatographic separation of Mephenesin and Ibuprofen was achieved by using Agilent C18 column (150mm×4.6mm, 3.2µ p.s). The system was operated at ambient temperature using a mobile phase consisting of Acetonitrile, 0.01M potassium dihydrogen phosphate pH 3.0 (60:40 v/v) isocrat...
4786
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PRODUCTION OF LACCASE BY NEWLY ISOLATED MARASMIUS SP. BBKAV79 IN SOLID STATE FERMENTATION AND ITS ANTIPROLIFERATIVE ACTIVITY
The aim of the present study was to investigate the production of laccase by Marasmius sp. BBKAV79 in Solid State Fermentation (SSF) and its antiproliferative activity. Experiments were also conducted to determine the variables that could affect activity of laccase. In particular, the effects of the initial moisture content, pH, temperature, and inoculum volume, incubation period in addition to ca...
5441
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FORMULATION AND EVALUATION OF CO-CRYSTALS OF POORLY WATER SOLUBLE DRUG
The present study is an attempt to formulate and evaluate cocrystals of poorly water soluble drug Darunavir by cooling crystallization method using succinic acid as coformer. Cooling crystallization method used to prepare the cocrystals of darunavir with succinic acid. The prepared cocrystals were characterized by Microscopic characters, Product yield, Surface morphology. (SEM), Differential scann...
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METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF IDELALISIB IN RABBIT PLASMA BY HPLC
A simple, rapid, sensitive, and accurate high performance liquid chromatography was developed for determination of Idelalisib (IL) in rabbit plasma using Ibrutinib as internal standard (IS). Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lympho...
4103
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OINTMENT OF METHANOLIC EXTRACT OF FICUS RELIGIOSA: A TRADITIONAL APPROACH IN WOUND HEALING IN RATS
The methanolic extract (ME) of leaves of Ficus religiosa (Family: Moraceae) was evaluated for their wound healing activity in rats. It was carried out in rats by employing excision wound models following topical application. The qualitative preliminary phytochemical analysis of ME indicated the presence of tannins, triterpenoids, alkaloids and steroids. All healthy animals of either sex were group...
4069
1319
STUDY OF ANALGESIC-NALBUPHINE AS A COMPONENT OF BALANCED ANAESTHESIA IN OTOLARYNGORHINOLOGICAL SURGERY
Back ground: Use of proper analgesics as adjuvant to balanced anaesthesia can calm the patient, reduce stress and decrease the need of higher doses of inhalation agents. Some examples of analgesics are opioids, NSAIDS, NDMA receptor antagonists (ketamine). Nalbuphine is a synthetic opioid agonist-antagonist analgesic of the phenantherene series. We conducted this study with the aim to observe the ...
4338
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EFFICACY OF GARLIC IN CONJUNCTION WITH PENTOXIFYLLINE IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS – A PRELIMINARY STUDY
Introduction and Objectives: Oral submucous fibrosis (OSMF) is a chronic, progressive, and irreversible disease of the oral mucosa. Though numerous modalities have been tried but all are palliative and have no curative value. Pentoxifylline possessing vasorelaxive and antifibrotic properties believed to potentiate the anti-inflammatory, anti-oxidant and immune modulating properties of garlic. So, ...
4887
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SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTICANCER EVALUATION OF BIS-[1,5]-BENZOTHIAZEPINES AGAINST HUMAN BREAST CANCER CELL LINE MCF-7
Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell lin...
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DESIGN & DEVELOPMENT OF NOVEL LIPID BASED CARRIER SYSTEM FOR DELIVERY OF PITAVASTATIN CALCIUM
The aim of this work is to prepare self-micro-emulsifying drug delivery system (SMEDDS) for oral bioavailability enhancement of a poorly water soluble drug, Pitavastatin. Solubility of Pitavastatin was determined in various vehicles. SMEDDS is mixture of surfactants, oils and co-surfactants, which are emulsified in aqueous media under conditions of digestive motility and gentle agitation that wou...
3828
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ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF IMPATIENS BALSAMINA SEED (KACI-T-TUMPAI) COLLECTED FROM COIMBATORE DISTRICT, TAMIL NADU, INDIA
The antimicrobial effects of I. balsamina seed hexane extract against Staphylococcus aureus, Klebsiella pneumonia, Proteus vulgaris, and Serratia marcescens were determined using the standard technique. As well as the phytochemical properties of the extract on the test isolates were also examined using the standard methods. The phytochemical components of the hexane extract of the I.balsamina seed...
4297
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DESIGN AND MOLECULAR DOCKING STUDIES OF SOME 1,3,4-THIADIAZOLE DERIVATIVES
In present investigation of some ethyl1-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl) - 5 - ethyl-2, 6-dimethyl – 4 - phenyl-1, 4-dihydro pyridine-3-carboxylate are designed and docked active site of cavity 1# of open channel voltage gated calcium channel protein (3DVE). The compounds evaluated in silico (docking) to distinguish their hypothetical binding mode using the X-ray crystal structure ...
3533
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ENHANCED BIOAVAILABILITY OF GLIMEPIRIDE THROUGH MICROEMULSION BASED TRANSDERMAL GELS
The objective of the present research work was to conduct in vivo pharmacokinetic study of microemulsion based transdermal gel of glimepiride for evaluating the enhanced bioavailability. Saturation solubility studies of the drug were conducted in various solvents and oils. Labrafil M 1944 CS, Tween 80 and Transcutol P were used as oil phase, surfactant and cosurfactants respectively for the prep...
3677
1285
ANTIOXIDANT AND ANTILEUKEMIC ACTIVITY OF VITEX NEGUNDO LEAF EXTRACTS
Vitex negundo is an Indian medicinal plant used to cure several diseases such as asthama, fever, headache, cancer and many other diseases. This study aims to determine the antioxidant potential and anti-proliferative activity of Vitex negundo methanolic leaf extract. Isolation of bioactive compounds involved liquid-liquid extraction of methanolic leaf extract by petroleum ether and chloroform. The...
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INVESTIGATION OF BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF EXCOECARIA AGALLOCHA, L.
Mangrove survives in the most hostile environment with fluctuating tidal and saline regime. The present work focused on a detailed study on quantitative estimation of phytoconstituents and DPPH radical scavenging activity of Excoecaria agallocha L., a mangrove from Kattiparambu and Chirackal of Ernakulam District, Kerala. Preliminary phytochemical investigation indicated the presence of biological...
3811
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PHYTOCHEMICAL EVALUATION AND HPTLC ANALYSIS OF PHOENIX SYLVESTRIS FRUIT EXTRACT AT TWO RIPENING STAGES
Phoenix sylvestris Roxb, commonly known as date sugar palm or wild date palm, grows naturally in the tropics and subtropics of the Indian subcontinent. The present study was aimed for phytochemical evaluation and to develop the high performance thin layer chromatography (HPTLC) fingerprint profile of methanolic extract of P. sylvestris at two ripening stages. The powdered plant material was extrac...
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1435
CLINICAL AND RADIOGRAPHIC EVALUATION OF PULPAL AND PERIRADICULAR TISSUE
Objective: The aim of the present study was to evaluate the clinical and radiographic aspects of pulpal and periradicular tissue for patient undergoes endodontic treatment. Patient and method: The present study was limited to patients who treated endodontically by postgraduate students of Conservative Department, School of Dentistry/Faculty of Medical Sciences between January 2014 to February 2015...
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SYNTHESIS, CHARECTERIZATION AND ANTIMICROBIAL ACTIVITY OF 5-METHYL -2, 4-DIHYDRO-3H-PYRAZOL-3-ONE-4-(4-SUBTITUTED) BENZYLPIPERAZINE DERIVATIVES
Synthesis of 6-Methyl-2, 4-dihydro-3H-pyrazol-3-one- 4- (4-substituted) Benzylpiperazine derivatives IVP a-e was carried out by bromination of Ethyl aceto acetate (I) with KBr. The reaction was carried out in the presence of Hydrochloric acid and tolune to produce Bromo-ethyl aceto acetate (II), it is further condensed with substituted Benzylpiperazines in presence of ethanol to obtain condensed c...
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A STUDY ON ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE REGARDING PHARMACOVIGILANCE AMONG HEALTHCARE PROFESSIONALS IN A TERTIARY CARE HOSPITAL, ANDHRA PRADESH
Objectives: The aim of this study was to assess knowledge, attitude and practice of the healthcare professionals about Pharmacovigilance in a tertiary care hospital, Rajahmundry, Andhra Pradesh. Materials and Methods: A cross-sectional questionnaire based study was carried out on healthcare professionals (Faculties, Postgraduates, Interns & Nurses) to assess the knowledge, attitude and practic...
5927
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THE STUDY OF SERUM VITAMIN D STATUS WITH INSULIN RESISTANCE IN OBESE ADOLESCENTS
Aim: To study the relationship between serum Vitamin D levels and insulin resistance in obese and non obese adolescents. Introduction: Vitamin D deficiency in obese adolescent is strongly associated with increased risk for diabetes, hyper tension and metabolic syndrome. Vitamin D insufficiency is a risk factor for developing impaired glucose in childhood obesity and is associated with insulin ...
3812
1064
ANALGESIC DRUGS IN DENTISTRY- A CROSS-SECTIONAL STUDY AMONG DENTISTS IN A PRIVATE DENTAL COLLEGE
Aim: The objective of this survey was to assess the awareness pattern of analgesic administration and the various factors impacting the prescription of analgesics. Materials and methods: Pretested interviewer administered questionnaire was distributed to 100 study subjects consisting of post graduates and dental practitioners in Chennai. The questionnaire was designed to contain questions regardin...
5017
1207
EVALUTION OF ANXIOLYTIC ACTIVITY OF LEPTADENIA RETICULATA PLANT
The persent study was designed to investigate the anxiolytic activity of ethanolic extract of Leptadenia reticulata plant. It is a folk medicine traditionally used in treatment of eye diseases, seminal debility, general weekness, cough, fever, asthma, sore throat and gonorrhea. The anxiolytic activity was evaluated by Elevated plus maze Test, Light-Dark Test, Hole-board Test and Social-intraction ...
3578
1405
EXTRACTION OF ESSENTIAL OIL FROM FLOWERS OF MESUA FERREA LINN. GC-MS ANALYSIS AND INCORPORATION IN COSMETIC PRODUCT.
Mesua ferrea Linn. is a flowering tree found in Western Ghats of India, belonging to family Clusiaceae. Extraction process was standardized by cold maceration method with n-hexane. Essential oil extracted from different parts of the flower was also subjected to GC/MS and headspace analysis. The GC/MS analysis of essential oils from whole flowers of M. ferrea shows following components. Alpha-Copae...
5276
1319
RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF AZELNIDIPINE
A simple and precise method was developed for the assay of azelnidipine from tablet formulation. The solvent system and wavelength were optimized in order to maximize the sensitivity of the proposed method, azelnidipine shows the maximum absorbance at 257 nm. The separation was achieved on HPLC binary gradient system equipped with HPLC 3000 series. The mobile phase was prepared with Methanol: Wate...
6138
2570
OPTIMIZATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE THEOCLATE WITH EFFERVESCENT TECHNOLOGY USING 32 FULL FACTORIAL DESIGN
The aim of the research work was to develop and optimize fast dissolving tablets of Promethazine Thecolate by direct compression using effervescent technology. For the investigation, purpose a 32 full factorial design was used to know the joint influence of two formulation variables, Crospovidone and Citric acid. The formulated tablets were evaluated for its percent friability and their disintegra...
3545
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IN VITRO ANTICANCER ACTIVITY OF BIOPHYTUM SENSITIVUM WHOLE PLANT EXTRACTS AGAINST CERVICAL AND LIVER CANCER CELL LINES
In the present study, the various extracts viz aqueous, ethanol, chloroform and Petroleum ether of Biophytum sensitivum whole plant were evaluated for the anticancer activity against cancer cell lines. The cervical (Hela) and liver cancer (HepG2) cell lines were used to screen the in vitro anticancer challenging with the B.sensitivum extracts. Concentration ranges from 20 to 100 microgram of B.s c...
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