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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 7 (2016) - Issue 5, May

Review Articles

 
Title
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1.

TRADITIONAL INDIAN MEDICINAL PLANTS WITH POTENTIAL WOUND HEALING ACTIVITY: A REVIEW

In last few decades, there has been a great progress in understanding the biochemical and cellular events of normal wound healing. Healing of wounds, either accidental or surgical interventions, involves complex activities of blood cells, tissues, soluble mediators, cytokines and several growth factors. This increased cellular activity of damaged tissue enhances metabolic demands and active drug t...

Sapna Saini, Anju Dhiman and Sanju Nanda*

Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1809-19

1809-19

8530

1971

2.

OFF-LABEL USE OF MEDICINES IN CHILDREN

Although plenty of information relating to drug utilization among adults is available, the literature pertaining to children is scarce. The majority of drugs prescribed have not been tested in children and safety and efficacy of children’s medicines are frequently supported by low quality of evidence.  This is explained by the lack of clinical research in this population, caused by ethical, sci...

Aamir Nabi Mir, Mohammad Ishaq Geer *

Dept. of Pharmaceutical Sciences, University of Kashmir, Srinagar, J & K, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).1820-28

1820-28

11145

2765

3.

POST APPROVAL CHANGES IN BIOLOGICAL PRODUCTS

The post approval changes are the changes made to biological products that have received an approval and to provide the data to support a change which would be considered sufficient to allow a determination of the impact of the change on the quality of the approved products as it relates to safety, efficacy and/or effective use of the products. After the approval of NDA or ANDA, the applicant may ...

Pooja Agarwal *, N. Banu, M. Manasa, G. Vimala, D. Savitha, S. Rani and M. Santhoshi

Geethanjali College of Pharmacy, Cheeryal (V), R.R Dist., Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1829-56

1829-56

3185

993

4.

NANO-THERAPEUTICS ARSENALS FOR INTERVENTION OF COLON CANCER

Nanoparticles have attracted the interest of many research groups and had been utilized in an increasing number of fields during the last decades. Various methods can be used to produce nanoparticles such as ionic gelation, solvent evaporation, microemulsion, emulsion cross linking and precipitation. This review covers the general description, preparation and the detailed description of crucial pa...

Ruchika* and Himanshi

RPIIT Technical and Medical Campus, Karnal, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1857-65

1857-65

2213

704

5.

NUTRITIONAL AND PHARMACOLOGICAL IMPORTANCES OF GENUS COSTUS: A REVIEW

The Genus Costus (Linn.) is an important medicinal plant belonging to the family Costaceae. The Genus as a whole is often called Spiral Ginger. The genus is represented by about 175 species distributed throughout the world. The aerial parts of the plant and the rhizomes are edible, the rhizome being good source of carbohydrate, starch, amylase, protein and lipid. Moreover the rhizome is an alterna...

Archita Behera, Sanjeet Kumar and Padan Kumar Jena*

Department of Botany, Ravenshaw University, Cuttack, Orrisa, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1866-73

1866-73

3704

945

6.

FUSED HETEROCYCLES AS A POTENT BIOLOGICAL AGENTS; RECENT ADVANCEMENT

Recently the synthesis of fused heterocyclic compounds seeks great attention of researches in the field of medicinal chemistry. Majority of the drug compounds contains heterocyclic ring in their structures and these heterocyclic skeleton contributes significantly in the biological profile of drug. The heterocyclic compound play significant role in synthetic chemistry and many heterocyclic derivati...

Upendra Bhadoriya* and Dinesh Kumar Jain

College of Pharmacy, IPS Academy, Rajendra Nagar, A. B. road, Indore (M.P.), India.

DOI: 10.13040/IJPSR.0975-8232.7(5).1874-80

1874-80

2738

731

7.

ROLE OF VITAMIN D IN DIABETES MELLITUS

Diabetes Mellitus (DM), a global health care problem has been a burden to the socioeconomic society. The increasing incidence highlights the need for innovative approaches for the prevention and management, despite availability of various therapies for managing disease and its complications. There are several factors that seem to play a role in development of DM including genetic, lifestyle, envir...

Abhishek Acharya, and Susheela Somappa Halemani *

Subbaiah Institute of Medical Sciences, Shimoga, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1881-88

1881-88

3503

813

8.

ONLINE AND OFFLINE TOOLS: CRISPR/CAS OFF-TARGET DETECTION

Genome engineering field is a new revolution in biological research and to this new field several restriction endonucleases are available. Out of all these, based on easier construction, sensitivity and specificity Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) preferred by scientists for research and industrial purposes. However, off-target DNA clea...

V. C. Sangar *, L. Samant , S. Pawar , P. Dhawale and A. S. Chowdhary

Department of Virology, Haffkine Institute for Training, Research and Testing, Mumbai, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1889-95

1889-95

4355

854

Research Articles

 
Title
Views
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Cited
9.

EVALUATION OF CIPROFLOXACIN EFFECT ON THE ANTIMALARIAL ACTIVITY OF SOME ANTIMALARIAL DRUGS IN PLASMODIUM BERGHEI INFECTED MICE

This study evaluates the effect of ciprofloxacin (CIP) on the antimalarial activity of artesunate (AS), artemether-lumefantrine (AL) and artesunate-amodiaquine using animal model. Some 120 albino mice infected with chloroquine sensitive Plasmodium berghei NK65 strain were used. The study was carried out in three phases. Phase 1 consisted of eleven groups treated with different doses of either AS, ...

E. E. Ayogu,*, O. Ugwuowo, K. C. Amorha and J. M. Okonta

Clinical Pharmacokinetic Research Unit, Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(5).1896-03

1896-03

3986

968

10.

COMPARATIVE EVALUATION OF PIOGLITAZONE HCL AND GLICLAZIDE -LOADED HPMC-PVA BLEND PATCHES

Transdermal drug delivery system (TDDS) involving HPMC-PVA patches were prepared as matrix-dispersion system with Pioglitazone HCl (PH) or Gliclazide (GZ) and drug release pattern from these patches were evaluated in-vitro as well as in-vivo. It has been found that 82.41% of Pioglitazone HCl and 70.12% of Gliclazide were released in-vitro in the period of 12 hours and the release patterns was zero...

Md. Kamrul Hasan, Md. Ajijur Rahman, Sharif Mohammad Shahin and Md. Anwar Ul Islam

Professor, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(5).1904-08

1904-08

2324

780

11.

THE EFFECT OF NANOENCAPSULATED CENTELLA ASIATICA L AND ZINGIBER OFFICINALE ROSC. VAR. RUBRUM COMBINATION TO PROMOTECOLLAGEN SYNTHESIS AND DECREASE THE DIAMETER OF ADIPOCYTE CELLS IN FEMALE WISTAR RATS

Cellulite is a normal condition judging from the medical aspect, but from aesthetics aspect, cellulite deserves more attention, especially for women. Centella asiatica is reported to promote both fibronectin and collagen synthesis. Meanwhile, Zingiber officinale is reported to have lipolysis activity. Combination of the two herbals is assumed to have complementary effect as anti cellulite agents. ...

Zullies Ikawati *, Retno Murwanti , Yenny Meliana and Witta Kartika

Depr of Pharmacology, Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Indonesia

DOI: 10.13040/IJPSR.0975-8232.7(5).1909-14

1909-14

2689

899

12.

SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND PETRA OSIRIS MOLINSPIRATION (POM) ANALYSES OF DICARBOXYLIC ACID AMIDES

Six new Phthalic acid amides of the general formula  C8H5O3-NH-R  were prepared by the reaction of Phthalic anhydride with various amines namely Glycine, N, N-diphenyl amine, 1-naphthyl amine, 4-amino toluene-3-sulphonic acid, Toluene-p-sulphonamide, m-nitro aniline. The synthesized compounds were characterized by using   IR, 1HNMR & 13CNMR spectroscopy. Petra Osiris Molinspiration (POM) a...

Md. Imran *, Md. A Choudhary, N. Kumar, Z. kousar , S. Shahida and F. Nohri

Department of Chemistry , The University of Azad Jammu & Kashmir Muzaffarabad, 13100, AJK, Pakistan

DOI: 10.13040/IJPSR.0975-8232.7(5).1915-27

1915-27

2222

782

13.

EFFECT OF DIFFERENT EXCIPIENTS ON THE RELEASE OF NORETHISTERON ACETATE FROM CHITOSAN-SODIUM ALGINATE POLYMERIC IMPLANTS

Biodegradable polymeric implant offers a novel approach for sustained drug delivery that provides an option to the patient of avoiding surgical retrieval of implant post-use. Chitosan, a biodegradable polymer extracted from the hard outer skeleton of shellfish, is used nowadays in many pharmaceutical applications (ophthalmic, nasal, sublingual, buccal, periodontal, gastrointestinal, colon-specific...

Sal Sabil Sohani, Khosnoor Jahan and Swarnali Islam *

Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(5).1928-37

1928-37

2339

727

14.

LIGAND BASED PHARMACOPHORE MODEL DEVELOPMENT FOR ANTI ANDROGEN RECEPTOR DRUGS FOR TREATING PROSTATE CANCER

The computational modeling and high throughput screening techniques have been used to identify small molecules that specifically target functional surface sites of the androgen receptor in Prostate cancer. Pharmacophore modeling, Virtual screening, docking based analyses is used for development of new chemical entities. The purpose of the current work is to establish pharmacophore model for the FD...

M. Rajalakshmi *, Sherlin Rosita A. and S. Krishnaveni

PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Tiruchirapalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).1938-47

1938-47

2057

716

15.

A STUDY ON THE EFFECT OF VIRGIN COCONUT OIL ON BENZO(A)PYRENE INDUCED GASTRIC NEOPLASIA IN MICE.

Objective: The present investigation is focused on detecting anti-carcinogenic potential of virgin coconut oil. Methods: The virgin coconut oil (VCO) from coconut endosperm was prepared by cold compression method. It was examined then for cytotoxicity by cell exclusion studies using trypan blue dye. Chemical carcinogenesis method using benzopyrene was used to study the anticarcinogenecity of VCO. ...

Anu Alex *, N. K. Nair , Shawn Tomy , K.Elango and C. R. Achuthan

Department of Pharmacology, JSS College of Pharmacy, Ooty (JSS University, Mysore), Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1948-55

1948-55

2683

537

16.

MOLECULAR MODELING AND DOCKING BASED STUDIES OF NOVEL CHALCONE SKELETON BASED COMPOUNDS ON GLUCOSAMINE-6-PHOSPHATE SYNTHASE ENZYME

Glucosamine-6-phosphate synthase (G6PS) (EC 2.6.1.16), is an one of the drug target for the anti microbial species. Systemic anti bacterial and anti fungal infections are of the growing problems in contemporary medicines, however only limited anti bacterial agents are in clinical practice for selective action with low toxicity. Then there is an emergency need for more effective version of existing...

CH.M.M. Prasada Rao*, S. A. Rehaman and Rajendra Prasad Yejella

Department of Pharmaceutical Sciences, QIS college of Pharmacy, JNTUK, Kakinada. AP, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1956-66

1956-66

1955

604

17.

POLY (METH) ACRYLATES NANOSPHERES OF CENTRALLY ACTING ANALGESIC DRUG FOR POSTOPERATIVE PAIN: IN-VITRO AND IN-VIVO CHARACTERIZATION STUDY

Postoperative pain management is prerequisite element for care of surgical patient. Objective of this study was to develop and evaluate nefopam hydrochloride loaded poly (meth) acrylates nanospheres (NFH-NS) for post-incisional pain treatment. Nefopam hydrochloride (NFH) is a centrally acting, non-opioid analgesic exclusive for treatment of post-incisional pain. NFH-NS were fabricated using eudrag...

Sukhbir Singh *, Neelam Sharma , Yash Paul Singla Sandeep Arora and Jitender Madan

Department of Research, Innovation and Consultancy, IKG Punjab Technical University, Jalandhar-Kapurthala Highway, Kapurthala, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1967-77

1967-77

1365

465

18.

ANTIDIABETIC, ANTIOXIDANT AND ANTI-HYPERLIPIDAEMIC ACTIVITY OF CUCUMIS CALLOSUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Cucumis callosus (Rottl.) Cogn. (Cucurbitaceae) is a highly branched very common prostate, perennial herb, distributed throughout India in the arid zones. Objective: To evaluate the antihyperglycemic potential of C. callosus fruit in experimental animal model. Materials and methods: Hyperglycemia was induced in rats by single intraperitoneal injection of STZ (55 mg/kg body weight). Three days afte...

S. Panda , M. Chakraborty , P. Majumder , S. Mazumder , S. Das , Pa. Kanti Haldar *

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.7(5).1978-84

1978-84

3036

626

19.

QUANTITATIVE DETERMINATION OF DRUGS IN BULK AND TABLET FORM BY USING TETRACYANOETHYLENE

The present work narrates UV-Visible spectrophotometric methods have been developed for the determination of selected drugs viz., Lamotragine (LMT), Venlafaxine hydrochloride(VFX), Valacyclovir hydrochloride(VCL) and Ractopamine hydrochloride(RAC) in bulk and their pharmaceutical dosage forms by using Tetracyanoethylene (TCNE) as reagent. These methods have been developed based on the formation of...

Bathini Srinivas, P. Yadagiriswamy and G. Venkateshwarlu*

Department of chemistry, University College of Science, Osmania University, Hyderabad, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).1985-90

1985-90

1851

470

20.

EVALUATION OF THE QUALITY OF SOME ANTIBIOTICS DISTRIBUTED IN ACCRA AND LAGOS

The persistent prevalence of poor-quality medicines in resource-limited settings has contributed significantly to the alarming global trends in antibiotic resistance. Antibiotics are among the most used, abused and counterfeited medicines and therefore require regular monitoring and surveillance to provide reliable data for proper healthcare delivery. This study evaluated the quality of a total of...

D. Osei-Safo *, H. A. Egbo, H. Nettey, D. Y. Konadu and I. Addae-Mensah

Department of Chemistry, P. O. Box LG56, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra – Ghana

DOI: 10.13040/IJPSR.0975-8232.7(5).1991-00

1991-00

1957

723

21.

RP-LC METHOD DEVELOPED FOR THE DETERMINATION OF ASCORBIC ACID IN VITAMIN C SYRUP PREPARATION

Ascorbic acid is one of the essential and most vital medicines needed to maintain healthy living. Due to its non-availability through endogenous biosynthesis in humans, it is arguably one of the most consumed Over-The-Counter drugs. Thus, a simple, precise, low-cost and accurate reversed-phase liquid chromatographic (RP-LC) method was developed and optimized to analyse for the percentage content o...

K. B. Mustapha *, A. A. Kelong, T. A. Adelakun, A. A. Theophilus and O. O. Obodozie-Ofoegbu

Department of Medicinal Chemistry and Quality Control 1, National Institute for Pharmaceutical Research and Development, Idu, Abuja, Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(5).2001-08

2001-08

2739

819

22.

AN IMPROVED ASSAY METHOD FOR THE ESTIMATION OF TICAGRELOR HYDROCHLORIDE BY REVERSE PHASE LIQUID CHROMATOGRAPHY

The current investigation was carried out to develop and validate a fairly simple, accurate, precise, reproducible and robust RP-HPLC method for the estimation of Ticagrelor Hydrochloride. The separation was achieved using Agilent Infinity 1220, Infinity Fast-LC (Pressure limit up to 600 bars) with auto sampler and PDA detector. The Chromatographic analysis was performed on ZORBAX Eclipse Plus 300...

M. A. Ambasana*, N. P. Kapuriya, K. M. Mangtani and K. D. Ladva

Department of Chemistry, Shree M. & N. Virani Science College, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2009-14

2009-14

2988

652

23.

CYTOTOXIC ACTIVITY AND PHYTOCHEMICAL INVESTIGATION OF PHYLLANTHUS EMBLICA L. LEAVES

The aim of this study is to investigate the cytotoxic effect of various extracts from Phyllanthus emblica L. According to Ayurveda this plant has potent anticancer activity and hence, this study is targeted at screening potential cytotoxic extracts using a yeast system. Yeast has been used as a model organism for many preclinical drug screens. In this study phytochemical extraction has been done b...

K. Desai * and V. Braganza

Department of Biochemistry, St. Xavier’s College, Ahmedabad, Gujrat, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2015-19

2015-19

2128

684

24.

DEVELOPMENT AND OPTIMIZATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES USING 33 FACTORIAL DESIGN

This experimental work aimed at formulating and systemically characterizing mucoadhesive amoxicillin microspheres for the eradication of H.pylori and its associated diseases. The  microsphere batches were prepared by emulsion-solvent evaporation technique with the use of carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier polymer. Initially 27 formulations were prepared using 33 ...

Anu Hardenia* and Arun Kumar Gupta

Department of Pharmaceutics, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2020-30

2020-30

2009

621

25.

STABILITY-INDICATING RP-UHPLC METHOD FOR DETERMINATION OF TELMISARTAN IN DRUG SUBSTANCE AND MARKETED FORMULATION

A simple, rapid and precise stability-indicating ultra high performance liquid chromatography (UHPLC) has been developed and validated for the estimation of telmisartan in drug substance and pharmaceutical dosage form. The chromatographic separation was achieved with a Poroshell 120EC-C18 column (4.6 x 50mm, 2.7µm) by using mobile phase acetonitrile: 50mM ammonium acetate buffer in the ratio of (...

Biswa Ranjan Patra*, S. Mohan and Nagaraj Gowda

Department of Pharmaceutical Analysis, PES college of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2031-39

2031-39

2115

626

26.

HIGH FREQUENCY DIRECT SOMATIC EMBRYOGENESIS FROM THE JUVENILE SHOOT BUDS OF CHLOROPHYTUM BORIVILIANUM SANT. ET FERNAND AND PRODUCTION OF ARTIFICIAL SEEDS

The study presents a protocol for mass propagation of Chlorophytum borivilianum through direct somatic embryogenesis. Direct somatic embryos occurred on the surface of juvenile shoot bud sprouts cultured on  Murashige and Skoog  medium  supplemented with 5 mg L-1 BAP, yielding a high frequency of direct somatic embryos. On the other hand, a much lower concentration of BAP (0.5 mg L-1) led to th...

A. Jha and Y. K. Bansal *

Plant Tissue Culture Laboratory, Department of Biological Science R. D. University, Jabalpur (MP), India

DOI: 10.13040/IJPSR.0975-8232.7(5).2040-49

2040-49

1840

534

27.

COST VARIATION ANALYSIS OF ANTIHYPERTENSIVE DRUGS AVAILABLE IN INDIAN MARKET: AN ECONOMIC PERSPECTIVE

Aim: To analyze the percentage cost variations among different brands of the commonly prescribed anti–hypertensive drugs. Materials and Methods: The cost of different brands of commonly used antihypertensive drugs was sorted out by referring latest CIMS, MIMS, Drugs Monitor and IDR. The cost of 10 dosage forms (Tablets / capsules) in INR of each brand, Cost Ratio and Percentage Cost Variation we...

Laxminarayana Kamath* and G. R. Satish

Department of Pharmacology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2050-56

2050-56

3708

743

28.

IN-VITRO ANTIMICROBIAL ACTIVITY OF CRUDE EXTRACT OF FICUS ARNOTTIANA MIQ. LEAVES (MORACEACE): AN ETHNOMEDICINAL PLANT

This study was carried out with an objective to investigate the antibacterial and antifungal potentials of leaves of Ficus arnottiana Miq. The aim of the study is to assess the antimicrobial activity and to determine the zone of inhibition of extracts on some bacterial and fungal strains. In the present study, the microbial activity of ethyl acetate, methanol and aqueous extracts of leaves of Ficu...

Gurpreet Kaur * and Satnam Singh

School of Pharmacy & Emerging Science, Baddi University of Emerging Sciences and Technology, Baddi (Solan) Himachal Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2057-64

2057-64

1843

635

29.

COLLECTION AND DATA-MINING OF BIOACTIVE COMPOUNDS WITH CANCER TREATMENT PROPERTIES IN THE PLANTS OF FABACEAE FAMILY

Medicinal plants therapeutic agents are a big source of information for a wide variety of chemical constituents which could be developed as new drugs. The present study focused on anticancer, antitumor anticarcinogenic and cancer preventive activities of bioactive compounds found in plants belonging to Fabaceae family. The bioactive compounds and their scientific details were mining from publicall...

Balan Velusamy, Saravanan Kaliyaperumal* and Arulpriya Raju

PG & Research Department of Zoology, Nehru Memorial College (Autonomous) Puthanampatti, Tiruchirapalli, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2065-73

2065-73

2224

860

30.

IN SILICO DESIGN, DOCKING, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES

Emergence of resistant bacterial and fungal strains towards existing antimicrobial agents is one of the major motives for research and development of new molecules to defend them. Oxadiazole is a major compound of heterocyclic nucleus for the development of new drugs. Oxadiazole ring system could be incorporated into many more ring systems which itself have their own activity and could lead to pot...

Pilmy Rose Wilson * and Shakkeela Yusuf

Department of Pharmaceutical Chemistry, Mallige College of Pharmacy, Silvepura, Chikkabanavara Post, Bangalore, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2074-82

2074-82

2297

797

31.

A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF ORAL DICLOFENAC AND DECREASED DOSE OF DICLOFENAC PLUS TOPICAL DICLOFENAC IN TREATMENT OF KNEE OSTEOARTHRITIS

Objectives: To compare efficacy and safety of topical plus reduced dose of   diclofenac to oral diclofenac in therapeutic dose. Method: The study was prospective, comparative and randomized, which included 50 patients suffering from knee osteoarthritis. Patients were randomized to receive either - oral diclofenac alone (50 mg thrice daily) (therapy1) or decreased dose of oral diclofenac and topi...

Alpa Gor, Nitin Kothari * and Pratha Keyurbhai Patel

Department of Pharmacology, Pramukhswami Medical College, Karamsad, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2083-89

2083-89

1992

559

32.

ISOLATION AND CHARACTERIZATION OF A TRITERPENOID FROM THE LEAVES OF AZIMA TETRACANTHA LAM.

Azima tetracantha Lam. (Salvadoraceae) is a traditional medicinal plant primarily used for mother care treatments after delivery. Based on literature survey, it was noticed that the evaluation of the biopotential of A. tetracantha, and its phytoconstituents are scarcely reported from plant materials growing in the state of Kerala, India.  An attempt was made to reveal the phytochemical profile of...

G. Gayathri *, Bindu R. Nair and V. Babu

Department of Botany, University Of Kerala, Kariavattom, Trivandrum, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2090-96

2090-96

2903

959

33.

FORMULATION DEVELOPMENT OF DONEPEZIL HYDROCHLORIDE ORAL DISINTEGRATING TABLETS USING QUALITY BY DESIGN APPROACH

This study posed a challenge for the risk management to research and development projects in a highly regulated and volatile pharmaceutical industry, in which projects are extremely long, complex, costly and prone to failure. Project management in new product development, must be efficient and effective. This emphasizes the importance of risk management. Quality by design (QbD) refers to an advanc...

Tejas B. Patel*, Tushar R. Patel and B. N. Suhagia

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2097-08

2097-08

3259

902

34.

TREATMENT WITH GLIPTINS AND STUDY OF THE VARIATIONS IN SERUM AMYLASE AND SERUM LIPASE LEVELS IN TYPE 2 DIABETES MELLITUS

Objective: To observe the variations in levels of serum amylase and serum lipase, in patients with type 2 DM after treatment with DPP-4 inhibitors. METHODS: Under this study, 174 Type 2 diabetes mellitus patients were analysed for variations in levels of exocrine pancreatic enzymes after use of dipeptidyl peptidase (DPP) 4 inhibitors. The effect was compared with those under treatment with other o...

Shilpa, A. Mishra, A. A. Mahdi, K. K. Gupta and M. L. Patel

Department of Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2109-15

2109-15

2296

735

35.

IN VITRO ANTICANCER ACTIVITY OF GMELINA ASIATICA L. LEAF AGAINST HUMAN BREAST CANCER CELL LINE (MCF-7)

The present study was taken to prove the cytotoxic effect of ethanolic extract of Gmelina asiatica leaf on human breast cancer cell line MCF-7. The in vitro cytotoxicity was evaluated by performing MTT assay. Cell morphological characteristics were observed by using phase contrast microscope. The results demonstrated in MCF-7 cancer cell lines treated with ethanolic extract of G. asiatica leaf sho...

A. R. Florence and S. Jeeva *

Department of Botany, Scott Christian College (Autonomous), Nagercoil, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2116-21

2116-21

2035

674

36.

COMPARATIVE HISTOLOGICAL, HISTOCHEMICAL AND PHYTOCHEMICAL STUDIES OF THE RAW DRUG JIVANTI FROM DIFFERENT RAW DRUG MARKETS OF KERALA

Jivanti is considered a stimulant and tonic in Ayurvedic literature. Its medicinal use dates back to about 4500 to 1600 BC, as mentioned in classical texts. Holostemma ada- kodien and Leptadenia reticulata are the two plants used in Ayurveda as source plants of the drug Jivanti. Roots of these plants are used in several Ayurvedic preparations. Though Ayurvedic Formulary of India mentions Leptadeni...

T. P. Girija * and A. B. Rema Shree

Department of Botany, MES Asmabi College, P. Vemballur, Thrissur, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2122-26

2122- 26

1894

530

37.

THE SUCCESS OF DIFFERENT APPROACHES TO THE DEVELOPMENT TO ANTIPLATELET DRUGS

The aim of this research is to precisely discuss and appraise the success of different approaches to the development to antiplatelet drugs. Platelets play a main function in haemostasis and the development of arterial thrombosis that is the final event complicating cardiovascular diseases and peripheral vascular diseases, and antiplatelet drugs improve survival of patients with these diseases. Ant...

Elsheikh A. M. Obied

School of Health Sciences, Ahfad University for Women, Omdurman, Sudan

DOI: 10.13040/IJPSR.0975-8232.7(5).2127-35

2127-35

1681

471

38.

ASSOCIATION BETWEEN ATHEROGENIC RATIO TO FASTING PLASMA GLUCOSE AND HbA1c

Hyperlipidemia is a common finding in uncontrolled Diabetes Mellitus (DM) and patients with DM generally show alteration in lipid profile, notably in triglycerides value. Research done in the past has pointed out the usefulness of Atherogenic Index of Plasma (AIP) as a useful parameter for the diagnosis of Type 2 DM. HbA1c is well established as gold standard to monitor long term diabetic control....

K. Revathy, D. Arunkumar, M. Gandhi and S. Swaminathan *

Senior Consultant and Head, Department of Biochemistry, Apollo Speciality Hospitals, Vanagaram, Chennai, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2136-41

2136-41

1876

544

39.

MORPHOLOGICAL VARIATION OF ABNORMAL MAXILLARY LABIAL FRENUM IN SOUTH INDIAN POPULATION

Introduction: The Maxillary labial frenum is a fold of the mucous membrane connecting the lip to alveolar process. The maxillary labial frenum is most commonly observed clinically with reference to the midline diastema. Objective: To analyse the most common type of abnormal Maxillary labial frenum in South Indian population and to determine the type of abnormal Maxillary labial frenum commonly ass...

Sandra Sagar*, J. Heraldsherlin and Sagar Moses

Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2142-46

2142-46

3255

697

40.

SCREENING OF SOY LECTIN: AS NEW ERA CANCER HEALING AGENT

The lectins are glycoproteins or sugar binding proteins of non-immune origin but are barred from sugar binding antibodies and enzymes. Lectins are isolated and purified from seeds of Glycine max by soxhlet extraction and dialysis. These collected crude lectins were centrifuged till pH is shifted downward to optimal pH for coprecipitation. Filtration of the same carried out on a Buchner funnel with...

A. T. Tande *, M. S. Lade , A. R. Patil , A. B. Patil and J. I. D‟souza

Tatyasaheb Kore College of Pharmacy 1, Warananagar, Kolhapur, (MS), India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2147-51

2147-51

1762

740

41.

DEVELOPMENT OF RP-HPLC METHOD FOR THE ESTIMATION OF IN VITRO AND IN VIVO SAMPLES OF KETOPROFEN IN BULK DRUG AND TRANSDERMAL DOSAGE FORM

A simple and accurate Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the estimation of ketoprofen in vitro samples and in vivo samples from bulk drug and from administered transdermal dosage form, using Spherosorb S5 ODS of 10cm X 4.6 mm column, (5μm particle size). Mobile phase for in vitro sample analysis and in vivo plasma samples consists of 0.01 ...

Kavitha Kotthireddy * and B. Rama Devi

College of Engineering, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana State, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2152-56

2152-56

1977

502

42.

EFFECT OF DIFFERENT PRETREATMENT ON IN VITRO SEED GERMINATION AND SEEDLING DEVELOPMENT OF SENNA ALATA LINN

Senna alata is an important medicinal and ornamental flowering tree, in the subfamily of Caesalpinioideae, which was found in diverse habitat in the tropics. Leaves or sap are used to treat several infections such as skin diseases, bronchitis, asthma and ringworm. The present study was design to investigate for conserve the important medicinal plant by establishing an efficient in vitro seed germi...

C. Karthika, K. Mohamed Rafi and S. Manivannan *

PG and Research Department of Biotechnology, Bharath College of Science and Management, Thanjavur, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2157-62

2157-62

1901

712

43.

ASSESMENT OF PHYTOCHEMICALS AND ANTIOXIDANT ACTIVITY OF MURRAYA KOENIGII LINN.

Objective: To analyze phytochemicals both qualitatively and quantitatively and to estimate in vitro antioxidant activity, total phenolic content and concentration of flavonoids of methanolic extract of leaf, stem and fruit of an important medicinal plant Murraya koenigii Linn. Methods: Phytochemical screening of extracts was carried out. Aluminium chloride colorimetric method was used to estimate ...

Pratima Vijayvargia* and Rekha Vijayvergia

Plant Pathology and Biochemistry Laboratory, Department of Botany, University of Rajasthan, Jaipur, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2163-67

2163-67

3014

717

44.

A STUDY ON THE ROLE OF DIETARY AGENT MOMORDICA CHARANTIA L ON PROTEIN GLYCATION

Protein glycation is a spontaneous post translational modification of proteins by excess sugars causing formation of advanced glycation end products (AGEs) in diabetic individuals and responsible for diabetes complications. A wide variety of anti-glycating agents have been reported & recently there has been interest in natural products with anti-glycation properties. Momordica charantia L (M. ...

Gini Garima, Neeraj Kumar Agrawal *, Shagufta Moin and Pankaj Kumar Gupta

Department of Pharmacology, Himalayan Institute of Medical Science, SRH University, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2168-73

2168-73

1802

550

45.

COST VARIATION ANALYSIS OF SINGLE NONSTEROIDAL ANTI-INFLAMMATORY AGENTS AVAILABLE IN INDIAN MARKET: AN ECONOMIC PERSPECTIVE

Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used drugs to manage a variety of acute and chronic conditions associated with pain and/or inflammation. In the Indian market, various NSAIDs group of drugs are available in different formulations. This creates a lot of problem with physician to decide the drug of choice for individual patients. Objective:  To evaluate price v...

Brijalkumar S. Patel*, Falguni M Chavda and Shailesh G. Mundhava

Department of Pharmacology, P.D.U. Government Medical College, Jamnagar Road, Rajkot, 360001 Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2174-80

2174-80

1860

552

46.

ASSESSMENT OF RATIONAL USE OF FIXED DOSE COMBINATION IN COMMUNITY PHARMACIES OF RESOURCE LIMITED SETTINGS OF ANDHRA PRADESH

Fixed dose combination (FDC’s) is the term, which generically used to mean a particular combination of active ingredient irrespective of the formulation or brand. Now a day’s irrational FDCs are more rapidly being marketed, which results in serious ADRs and reduction of patient quality of life. The study aims at assessing the rational usage of fixed dose combinations in community pharmacies by...

S. M. G. Ishrar *, Mohanraj Rathinavelu and Yiragamreddy Padmanabha Reddy

Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research–RIPER, Anantapuramu, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2181-86

2181-86

2224

660

47.

DESIGN AND OPTIMIZATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF SITAGLIPTIN

In the present study, Gastro retentive floating drug delivery systems (GFDDS) of sitagliptin, an anti diabetic drug, have been designed to increase the therapeutic efficacy & gastric residence time and to reduce frequency of administration. Therefore a sustained release medication was advantageous so as to achieve the prolonged therapeutic effect and to reduce peak and valley effect in plasma ...

Mohammed Gulzar Ahmed*, A. Sanjana and Vangapandu Rajeev

Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2187-93

2187-93

1752

526

48.

HIGH PRESSURE LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ACYCLOVIR IN BULK AND MARKETED FORMULATION

A simple, selective, rapid and economical High Performance Liquid Chromatography (HPLC) method was developed for estimation of Acyclovir in bulk and marketed formulation. Chromatographic separation and estimation was achieved in a run time of  6.482 minutes on Hemsil C18- 5U (250 × 4.6 mm, 5μm) using Acetonitrile and pH adjusted water (6.74) in the ratio of 10:90 v/v at flow rate of 0.5ml/min. ...

Suchita V. Ghumre *, Varsha M. Jadhav and Vilasrao J. Kadam

Bharati Vidyapeeth’s College of Pharmacy, C.B.D Belapur, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2194-00

2194-00

2147

619

49.

INDUSTRIAL ENZYMES: LIPASE PRODUCING MICROBES FROM WASTE VOLATILE SUBSTANCES

Lipase is an important of extracellular thermostable enzyme that has received considerable attention for potential use in the food industry. Hence to achieve large scale production of gram positive and negative organism is commercially important lipase enzyme under the fermentation. Lipases are produced by microorganisms such as bacteria and fungi. However, we have focused on bacterial microbial l...

G. M. Muthumari, S. Thilagavathi and N. Hariram*

Department of Biotechnology, Kalasalingam University, Krishnankoil, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2201-08

2201-08

10200

1232

50.

HISTOARCHITECTURE AND BIOCHEMICAL STUDIES OF EPIDIDYMIS IN MALE RATS INDUCED BY AQUEOUS EXTRACT OF JUSSIAEA REPENS L

Different herbal Plants are used globally for safe and natural source of medicine from ancient ages. Jussiaea repens L, is a medicinal herb that has been reported to have non toxic antigonadal activity, which reduced the sperm count, motility, viability and morphological alteration of spermatozoa in rats. It also alters histoarchitechture vis-à-vis functions of testicular tissues by altering the ...

Subhasish Ghosal, Indrani Chakraborty and Nirmal Kr Pradhan *

P.G Department of Physiology, Hooghly Mohsin College, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2209-18

2209-18

2269

615

51.

PLATELET ENHANCING EFFECT OF ECLIPTA ALBA IN ALCOHOL INDUCED THROMBOCYTOPENIC THROMBOCYTOPENIC RATS

Thrombocytopenia is a common hematological finding with variable clinical expression. Low platelet count may be the initial manifestation of infections such as HIV, hepatitis, and also associated with some viral infection like dengue hemorrhagic fever, malaria, etc. In the present study, Methanol extract of Eclipta alba was evaluated at a dose of 200 mg/kg body weight for 7 days in alcohol induced...

C. Nandini , B.Y Sathish Kumar , K. Jayashree, K. Mruthunjaya , K.Johnson and S.N. Manjula*

Department of Pharmacognosy, JSS College of Pharmacy, JSS University, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.7(5).2219-30

2219-30

2534

692

52.

SOLID SUPPORTED MICROWAVE ASSISTED RAPID SYNTHESIS OF 1, 3, 4 OXADIAZOLES

We have carried out solid supported ,solvent free condition, microwave assisted rapid synthesis of 1- (2,5- substituted diphenyl)-1, 3, 4- oxadiazol -3(2H) - yl) ethanone (3a-3k) by cyclization of N'- (substituted phenyl methylidene) substituted  benzohydrazide (2a-2k)  in the presence of acetic anhydride and silica gel ( solid support) for 3-4 minutes by microwave irradiation  giving excellent...

Bhagyashri Lole, Shubhangi Waghmale and Pravina Piste *

P.G. Department of Chemistry, Yashavantrao Chavan Institute of Science Satara, (Mah.), India

DOI: 10.13040/IJPSR.0975-8232.7(5).2231-35

2231-35

1675

567

53.

EFFECT OF NUTRIENTS ON LIVER MARKER ENZYMES OF WISTAR RATS

A wide range of compounds are found to be effective against cancer for example Vitamin D3, lysine, proline, gallate, quercetin, etc.  Glucosinolates from cabbage are secondary metabolites hydrolyzed by the enzyme myrosinase 1. Their breakdown products such as isothiocyanates, nitriles and thiocyanates, are chemically very reactive, and they are known for their bioactive characteristics, such as a...

K. Talreja and A. Moon*

University Department of Biochemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharastra, India

DOI: 10.13040/IJPSR.0975-8232.7(5).2236-41

2236-41

1639

537

54.

FORMULATION AND EVALUATION OF LEVOCETIRIZINE LOADED MUCOADHESIVE MICROSPHERES FOR NASAL DELIVERY

The purpose of research work was to develop and optimize mucoadhesive microspheres of levocetirizine for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy and at the same time increase the Local  absorption of drug and reducing systemic side effects and also to develop unique delivery system for patients suffering from allergy and rhinitis. Chitosan (mucoa...

Jaideo Pandey * and Pushpendra Kumar Tripathi

Department of Pharmaceutics, R.R.S. College of Pharmacy, Amethi, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(5). 2242-51

2242-51

2227

561