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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Volume 11 (2020) - Issue 10, October

Review Articles

 
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1.

A COMPREHENSIVE REVIEW ON VIRAL ZOONOSIS: EMPHASIZING ON PATHOGENESIS, DIAGNOSIS, TREATMENT, PREVENTION STRATEGIES AND FUTURE PERSPECTIVES

Zoonoses are human diseases caused by animal pathogens or animal diseases that are transmissible to humans. They are caused by all types of pathogenic agents, including bacteria, parasites, fungi, viruses, and prions. Zoonotic diseases can be transmitted to humans by infected saliva, aerosols, contaminated urine or feces, and direct contact with the animal or pathogenic microbes. Furthermore, tran...

N. Jain *, P. Saiju and R. Jain

Sagar Institute of Research Technology & Science-Pharmacy, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4712-38

4712-4738

431

333

2.

ACRIDINE A VERSATILE HETEROCYCLIC MOIETY AS ANTICANCER AGENT

Acridine is a heterocyclic nucleus consisting of three fused rings heterocyclic moiety and a presence of Nitrogen in the ring structure. It is used in a large number of therapeutically agents for curing ailments like antimalarial, antiseptics, abortifacient, anticancer, and so on because of its adjuvant molecule attached to it. It possesses high pharmacological properties mainly with respect to ca...

N. B. Panchal *, P. H. Patel, N. M. Chhipa and R. S. Parmar

Parul Institute of Pharmacy and Research, Parul University, Waghodia, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4739-48

4739-4748

367

176

3.

MEDICINAL PLANTS AND PHYTOCHEMICALS AGAINST PSEUDOMONAS AERUGINOSA QUORUM SENSING

Medicinal plants are significantly used in the cure of various ailments from ancient times. Literature suggests that traditional medicinal plants from Fabaceae, Lamiaceae, Myrtaceae, and Anacardiaceae, Combretaceae family are widely studied, and they potentially inhibit quorum sensing, a bacterial communication mechanism that leads to the pathogenesis. Plants such as Anogeissus leiocarpus, Brassia...

J. Murugesan and S. K. Sripathi *

Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4749-73

4749-4773

261

158

4.

LIPID-BASED NANOCARRIER DRUG DELIVERY SYSTEM FOR BRAIN TARGETING THROUGH NASAL ROUTE: A REVIEW

The majority of the drugs that are available in the market which are intended for activity in the central nervous system, are not capable of being transported across the Blood-brain barrier. The nasal route of drug administration is one of the most promising routes of drug administration that can permeate the drug through BBB. The permeability of drugs across the BBB is depending on the physicoche...

K. Anilkumar, K. Sakthivel and S. Venkatachalam *

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4774-83

4774-4783

269

118

5.

NANOSTRUCTURED LIPID CARRIERS: A NOVEL TARGETED DRUG DELIVERY SYSTEM

Over the previous decade, several drug delivery systems have come into view, and an alluring part of this is the advancement of nanoparticle systems. Lipid drug delivery systems has considered as one of the emerging technologies and obtained attention due to features like biocompatibility, lipophilic characteristics. Among nanoparticle Nanostructured lipid carriers (NLC) have numerous advantages t...

D. Patil *, S. Pattewar, S. Palival, G. Patil and S. Sharma

Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4784-93

4784-4793

238

108

6.

AN OVERVIEW ON THE TRENDS, FEATURES AND APPLICATIONS OF ROBOTIC SURGERY

In the era of recent technology, robotic surgery will be the ruler of the medical world with its attributes, its journey from a mere idea to today’s world’s surgical epitome. Using the methods of telerobotic visualization and controlling systems, this technology works towards improvement in all the fields of medicine and patient care. Robotic surgery dwells on the functionality of the most wid...

S. Shettigar, V. Yadav and V. G. Kanase *

Department of Pharmacology, Oriental College of Pharmacy, Sanpada West, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4794-04

4794-4804

222

32

7.

A COMPREHENSIVE REVIEW ON OSMOTICALLY CONTROLLED ORAL DEVICE

The most well-known widely used route of administration among all the routes that have been explored for the systemic delivery of drugs is oral drug delivery. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that us...

P. Banerjee * and T. K. Satpathy

Gupta College of Technological Sciences, Asansol, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4805-21

4805-4821

88

48

8.

NANOSUSPENSION: A PROMISING DRUG DELIVERY SYSTEM FOR POORLY WATER SOLUBLE DRUG AND ENHANCED BIOAVAILABILITY

Nanosuspension consists of a submicron colloidal dispersion of pharmaceutically active ingredient particles in the liquid phase, which is stabilized by surfactant. Poor water solubility is a major problem for the manufacturing of formulation. The drug particle reduces leads to enhance the surface area as well as bioavailability. Nanosuspension prepared by way of a number of methods. Techniques suc...

M. S. Hussain *, A. B. Ahmed and J. Debnath

Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Hattkhowapara, Azara, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4822-32

4822-4832

100

44

9.

LYOPHILIZATION- A PROCESS OF OPTIMIZATION OF DOSAGE FORMS

Freeze-drying is a method of removing water by sublimation of ice crystals from frozen material. Suitable parameters of process application allow us to obtain the best quality products compared to products dried with traditional methods. In the pharmaceutical field, lyophilization has become an important subject to ongoing development and its expansion. In this 21st century, Lyophilization emerges...

A. Pande *, P. Dhekale and V. Thorat

Department of Pharmaceutics, PDEA’s Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4833-45

4833-4845

75

40

10.

ROLE OF TERPENOIDS AS HEPATOPROTECTIVE

The liver is the most vital organ in our body, involved in several vital functions such as metabolism, secretion, storage as well as detoxification of several drugs and xenobiotic. Liver cell injury caused by various toxic chemicals like certain antibiotics, chemotherapeutic agents, carbon tetrachloride, thioacetamide, excessive alcohol consumption microbes and so, on. Due to liver disease worldwi...

K. Jain * and M. Chandana

Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4846-58

4846-4858

101

39

11.

ANTICANCER POTENTIAL OF PLUMBAGO ZEYLANICA LINN. AND ITS ISOLATED CONSTITUENT PLUMBAGIN: A REVIEW

Varieties of natural products have been proved as a rich source of phytoconstituents which are reported for a wide range of therapeutic potential. Plumbago zeylanica L. Is one of the herbs which are traditionally used for its therapeutic value. It is reported for several bioactive chemical constituents like naphthoquinones, flavonoids, alkaloids, glycosides, steroids, tri-terpenoids, tannins, fixe...

H. S. Kapare *, S. R. Metkar and S. V. Shirolkar

Dr. D. Y. Patil Unitech Society’s, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4859-65

4859-4865

104

70

12.

PARKINSON’S DISEASE: ADVANCES IN PRECLINICAL SCREENING MODELS

About 1.5% of the world's population is suffering from Parkinson's disease, mostly above 55 years of age. It is identified by dopaminergic neuron loss in the striatum's Substantia nigra & dopamine loss (DA). The disease of Parkinson is the second most widespread neurodegenerative disorder. It adversely affects the motor system as the disease increases the destruction of the motor system. It is...

S. Khan, I. Ansari *, C. Singh, F. Bamne and S. Kapadia

Department of Pharmacology, Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4866-73

4866-4873

74

44

13.

A SYSTEMATIC REVIEW ON DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE AND FAST DISSOLVING FORMULATIONS FOR ANTI-DIABETIC DRUGS OVER PAST DECADE

Diabetes mellitus is the heterogeneous metabolic disorder caused by the high blood sugar level. Untreated high blood sugar can damage kidneys, eyes, nerves and other organs. Type 1 diabetes mellitus disorder is caused by the lack of insulin hormone while type 2 diabetes mellitus is a disorder of insulin resistance by β cells of the pancreas. For the management of type 2 diabetes mellitus differen...

M. K. Munde *, N. S. Kulkarni and D. B. Sen

Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4874-83

4874-4883

85

63

14.

APPLICATION OF NANOTECHNOLOGY FOR TREATMENT OF ANGINA PECTORIS AS CARDIOVASCULAR DISEASE: A REVIEW

Angina Pectoris is the medical term for chest pain or discomfort due to coronary heart disease. The drawback of the marketed formulation is required repeated administration of the drug due to low bioavailability. Therefore, it utilized a nanotechnology technique for prevention of drawback of marketed formulation. Polymeric nanoparticles have been in preferential list when it comes to nano-drug del...

H. K. Dewangan * and A. Garg

Institute of Pharmaceutical Research, GLA University, Chaumuhan, Mathura, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4884-95

4884-4895

87

46

Research Articles

 
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15.

INHIBITION OF ISLET AMYLOID POLYPEPTIDE FIBRILLATION BY OKRA SEED EXTRACT-COATED GOLD-NANOPARTICLES

In recent work, an ethanolic extract of okra seeds was successfully conjugated onto gold nanoparticles (AuNPs) via a reduction reaction that has been developed by our laboratory. Because of eliciting antioxidant activity and the presence of g-sitosterol in the extract, such synthesis methodology could be applied. The resulting okra-AuNPs were physically characterized by different methods, includin...

S. Manee, M. Wang, F. Usman, P. Wongwitwichot and J. Kaewsrichan *

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-yai, Songkhla, Thailand.

DOI: 10.13040/IJPSR.0975-8232.11(10).4896-01

4896-4901

278

134

16.

APHRODISIAC AND SPERMATOGENIC POTENTIAL OF UNSAPONIFIABLE FRACTION FROM SEEDS OF HYGROPHILA SPINOSA T. ANDER IN RATS

Seeds of Hygrophila spinosa T. Ander (Acanthaceae) are traditionally used as an aphrodisiac and spermatogenic in the Indian System of Medicine. Studies were planned to evaluate the effect of unsaponifiable (sterol-enriched) fraction from chloroform extract, of the seeds of Hygrophila spinosa as spermatogenic and as aphrodisiac in-vivo, using rats as experimental animals. An unsaponifiable fraction...

N. Vyas *, K. Gamit and M. Raval

Department of Pharmacognosy and Phytochemistry, Ramanbhai Patel College of Pharmacy, CHARUSAT Campus, Charotar University of Science and Technology (CHARUSAT), Changa, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4902-09

4902-4909

218

93

17.

TOXICITY STUDIES OF BOUGAINVILLEA GLABRA AND MUCUNA PRURIENS

The present study was aimed to evaluate the acute toxicity study and subchronic toxicity study with methanol extracts of Bougainvillea glabra and Mucuna pruriens on Wistar albino rats. The acute dose was administered at 2000 mg/kg body weight on 1st day and observed for 14 days, while chronic dose was given at 250, 500, and 1000 mg/kg b.w. for 90 days. In subchronic toxicity study, hematological (...

R. G. Krishna and R. Sundararajan *

GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4910-17

4910-4917

223

86

18.

EFFECT OF QUERCETIN AND NERVE GROWTH FACTOR ON BIOCHEMICAL PARA-METERS OF THE BRAIN TISSUE IN RATS WITH EXPERIMENTAL NEURO-DEGENERATIVE DISORDER

The work was initiated to induce a toxic model of a neurodegenerative disorder with Alzheimer’s disease symptoms in rats and to study the effect of quercetin, an anti-oxidant, and nerve growth factor on some biochemical parameters and parameters of behavioral performance of the animals. It was established that upon induction of the neurodegenerative disorder by an intranasal administration of al...

T. M. Ishankhodjaev *, B. R. Zainutdinov, M. A. Mustafakulov, E. A. Ibragimova, Z. Z. Ibragimov, S. U. Irgasheva, N. I. Mamadalieva and T. S. Saatov

Institute of Biophysics and Biochemistry Under Mirzo Ulugbek National University of Uzbekistan, 174 University Town, Olmazor District, Tashkent, Republic of Uzbekistan.

DOI: 10.13040/IJPSR.0975-8232.11(10).4918-23

4918-4923

214

81

19.

FORMULATION AND EVALUATION OF LINEZOLID LOADED SOLID LIPID NANOPARTICLES AS TOPICAL GEL

Linezolid loaded Solid Lipid Nanoparticles (SLN) were prepared and then incorporated in a topical gel as a carrier. The formulation was prepared by solvent injection method followed by probe sonication for reducing particle size. Excipients like lipids (Phospholipon 90H, Lipoid S-100, and Lipoid S-75) and emulsifier (Tween-80, Span-20, and poloxamer-407) were optimized using Taguchi L9 orthogonal ...

M. Begum and N. B. Shaik *

Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4924-33

4924-4933

254

106

20.

A STUDY ON TERNARY MIXTURE OF PEPTIDE USING ULTRASONIC, IN-VITRO AND IN-SILICO PROCESSES

Penetrating biomolecules by ultrasonic techniques is an innovative and influential tool for characterizing their physicochemical properties. Peptides have been used as extensive applications in drug construction and as an ingredient in nutritional complements. An investigation based on the behavior of the promulgation of ultrasonic waves in solids and the liquid system is now rather well recognize...

R. Padmavathy *, K. Dhanalakshmi and R. Geetha

PG & Research Department of Physics, Seethalakshmi Ramaswami College, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).4934-39

4934-4939

64

33

21.

FORSKOLIN INDUCED MORPHOLOGICAL AND OVARIAN DEFORMITIES IN THE EXORISTA BOMBYCIS (UZI FLY) AND ANTI-FEEDENT ACTIVITY OF FORSKOLIN

Forskolin is a heterocyclic labdane-type diterpenoid extracted from the roots of the plant of Coleus forskohlii (Lamiaceae) has been studied in depth for its broad range of pharmacological properties. Coleus forskohlii aids in the control of pestilence of Uzi fly, Exorista sorbillans, and Exorista bombycis one of the gravest ecumenical pests in sericulture industry. Forskolin affected moulting; de...

S. Y. Nayini *, C. S. R. Nalagoni and S. S. Raju

Department of Zoology, Sarojini Naidu Vanita Maha Vidhyala, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4940-44

4940-4944

64

30

22.

FORMULATION OPTIMIZATION OF BENZYDAMINE HYDROCHLORIDE NANOSPONGES LOADED HYDROGEL FOR TREATMENT AGAINST MOUTH ULCERS

This study is aimed at encapsulating Benzydamine Hydrochloride into nanosponges that involve different crosslinkers to polymers in the ratio of 1:1, 1:2, 2:3, etc., which are used, in order to protect these structures, to control their release and maintain their site-specificity. Emulsion Solvent Diffusion technique was applied for the formation of nanosponges, which were incorporated into carbopo...

J. Shaji * and T. Vaswani

Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4945-56

4945-4956

92

42

23.

A COMPARATIVE EVALUATION OF LASER ASSISTED & CONVENTIONAL OPEN FLAP SURGICAL DEBRIDEMENT PROCEDURE IN PATIENTS WITH CHRONIC PERIODONTITIS – A CLINICAL AND MICROBIOLOGICAL STUDY- A PILOT PROJECT

Background and Objectives: Current research suggests several advantages of the adjunctive use of lasers in periodontal therapy. The aim of this study was to assess and evaluate the comparative therapeutic effects of laser-assisted and conventional open flap debridement procedures. Materials and Methods: 30 sites in 15 patients (9 males and 6 females), age range (25-50 yrs) with chronic periodontit...

S. Shetty *, K. Shetty, S. Alghamdi, N. Almehmadi and T. Mukherjee

Dentistry Program, IBN Sina National College of Medical Sciences, Jeddah, KSA.

DOI: 10.13040/IJPSR.0975-8232.11(10).4957-65

4957-4965

76

38

24.

INFLUENCE OF CULTURAL PARAMETERS ON THE PRODUCTION OF BIOACTIVE METABOLITES BY STREPTOMYCES RECTIVERTICILLATUS VJMS-8 ISOLATED FROM SOUTH COASTAL REGIONS OF ANDHRA PRADESH, INDIA

Adaptation of marine actinobacteria to extreme climatic conditions such as high salinity, high pressure and high temperature has modified their physiological conditions to survive and elaborate novel bioactive metabolites. Among the different actinobacterial strains isolated from coastal regions of Guntur District, Andhra Pradesh, India, one potent strain with broad-spectrum antagonistic activity ...

M. M. Swapna and M. Vijayalakshmi *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4966-73

4966-4973

86

31

25.

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL CHALCONES WITH METHANE-SULFONYL END AS POTENT ANALGESIC AND ANTI-INFLAMMATORY AGENTS

In the present study, eleven new chalcones bearing a methanesulfonyl group at para position have been synthesized by the condensation of 4-methylsulphonylacetophenone with different para-substituted aromatic aldehydes. The structures of the newly synthesized molecules were elucidated by spectroscopic methods such as as1H NMR, 13C NMR, and mass. These compounds were screened for their anti-inflamma...

B. Lakshminarayanan *, N. Kannappan and T. Subburaju

Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4974-81

4974-4981

73

45

26.

FORMULATION AND IN-VITRO EVALUATION OF MESALAMINE MUCOADHESIVE TABLETS FOR COLONIC DRUG DELIVERY

The objective of the present study is to develop a colon targeted drug delivery system by using sodium alginate as a carrier for Mesalamine. Matrix tablets containing various excipients and sodium alginate were prepared by wet granulation technique using different binder systems. The prepared tablets were evaluated for hardness, weight variation, drug uniformity, friability, and in-vitro drug rele...

P. K. Sahoo *, S. Das, A. C. Sahoo and S. K. Kanungo

Department of Pharmaceutics, Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4982-90

4982-4990

64

39

27.

VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RILPIVIRINE AND DOLUTEGRAVIR IN BULK FORM

New simple, sensitive, and validated stability-indicating RP-HPLC method has been developed for the simultaneous estimation of Rilpivirine and Dolutegravir in its bulk form. Chromatographic separation was achieved on a Hypersil ODS (250mm × 4.6mm i.d., 5µm) maintained at ambient temperature by a mobile phase consisted of methanol and water (80:20v/v) and a flow rate of 1.0mL/min with a load of 2...

K. S. Reddy *, S. S. Shirisha and K. P. Kumar

Pharmacognosy & Phytochemistry, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4991-97

4991-4997

74

55

28.

QUALITY OF LIFE OF POSTMENOPAUSAL WOMEN RECEIVING PLANT-BASED PHYTOESTROGENS

Background: A gradual and continuous loss of oestrogen may place the middle age woman at the risk of getting menopause symptoms, which profoundly affects her comfort. A phytoestrogen is a natural plant hormone similar to the female hormone oestrogen. Eating dietary phytoestrogen, improve the health standard of women by producing and regulating oestrogen level in the body. Materials and Methods: A ...

S. Padmapriya * and S. S. Kumar

Yenepoya Nursing College, Yenepoya Deemed to be University, Mangaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).4998-03

4998-5003

84

46

29.

ANTI-ESKAPE ACTIVITY OF GREEN SYNTHESIZED SILVER NANOPARTICLES FROM PICRORHIZA KURROA ROYLE EX BENTH.

The facts like developing resistance in bacterial pathogens against conventional antibiotics, emergence of new infectious agents etc. have been leading the scientists to tedious research activities to find out antimicrobial drugs with novel modes of action. Among the multidrug-resistant (MDR) bacterial species that pose threat to human life, the IDSA has identified a group pathogens known as ESKAP...

M. Musthafa *, K. Gobianand and M. Manohar

Department of Microbiology, Vivekanandha College of Arts and Sciences for Women, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5004-09

5004-5009

85

35

30.

QUANTIFICATION AND METHOD VALIDATION OF DICYCLOHEXYLUREA CONTENT IN FOSAPREPITANT DIMEGLUMINE DRUG SUBSTANCE BY REVERSE PHASE HPLC

A simple, sensitive, and rapid reverse phase High-Pressure Liquid Chromatography (HPLC) method was developed and validated for the quantification of residual Dicyclohexylurea in Fosaprepitant dimeglumine drug substance at trace level. The method was optimized on Zorbax Eclipse XDB-C8, 250 mm × 4.6 mm, 5µm with column oven temperature maintaining at 35 °C with flow rate at 0.7 ml/min. Mobile Pha...

M. V. Kishore, T. Sivarao, K. R. Srinivas, C. V. Satyendranath, V. J. Kumar *, K. S. R. P. Kumar and N. Sreenivas

Analytical Research, APL Research Centre-II Aurobindo Pharma Limited, Sangareddy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5010-16

5010-5016

58

39

31.

DEVELOPMENT AND VALIDATION OF GC-MS METHOD FOR THE TRACE LEVEL DETERMINATION OF STRUCTURALLY ALERT ALKYL HALIDE IMPURITIES IN CILASTATIN SODIUM DRUG SUBSTANCE

A Simple and trace level-sensitive Gas chromatography with mass spectrometer (GCMS) method was developed, optimized and validated for the determination of seven potentially genotoxic impurities which are having structural alerts i.e., 1-Bromo-5-chloropentane (PGI-1), Ethyl-6-chloro-2-oxo hexanoate (PGI-2), Methyl-7-chloro-2-oxo hepta-noate (PGI-3), Ethyl-7-chloro-2-oxo heptanoate (PGI-4), Ethyl-7-...

K. D. Raja, V. S. V. Ramana, K. R. Babu, B. K. Babu, V. J. Kumar *, K. S. R. P. Kumar and H. K. Sharma

Department of Analytical Research, Aurobindo Pharma Limited Research Centre-II, Sangareddy, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5017-26

5017-5026

79

39

32.

FORMULATION AND IN-VITRO DRUG RELEASE STUDY OF CONTROLLED RELEASE TABLET OF NIMODIPINE

At present more than 200 oral continued/controlled/ expanded/altered discharge details are accessible in the worldwide market. In India, notwithstanding, just constrained items are financially affordable. Making a stride ahead from assembling traditional dose structures, the advancement of controlled drug delivery systems. Controlled drug delivery systems have been created to improve the following...

D. Singh *, D. Singh and D. K. Chanchal

Agra Public Institute of Technology and Computer Education, Artoni, Agra, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5027-38

5027-5038

91

41

33.

VALIDATION OF GAS CHROMATOGRAPHY (GC) METHOD FOR RESIDUAL SOLVENT IN BROMPHENIRAMINE MALEATE (API)

Active Pharmaceutical ingredient (API) of pharmaceutical bulk drug Brompheniramine Maleate (API) was validation by gas chromatography. Aim for this article was to check the Residual Solvents in Brompheniramine Maleate (API) by Gas Chromatographic technique. To validate a Gas Chromatographic method for detection and Quantification of Residual Solvents Methanol, Isopropyl Alcohol, DMSO and -O-Xylene...

A. Solunke, S. B. Lakhmapure, S. Kothari and M. V. Lokhande *

Department of Chemistry, Sathaye College, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5039-52

5039-5052

70

38

34.

ANTI-PROLIFERATIVE AND APOPTOSIS INDUCING EFFECT OF NARAVELIA ZEYLANICA L. AGAINST LUNG CANCER CELL LINE A549

Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and ...

B. Umarani * and K. Saravanan

PG & Research Department of Zoology, Nehru Memorial College, Puthanampatti, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5053-58

5053-5058

71

50

35.

IN-VITRO ANTI-OXIDANT ACTIVITY OF ELYTRARIA ACAULIS

The overproduction of oxidants in the body leading to different side effects and chronic diseases, including oxidative stress. The oxidative stress is the overproduction of the oxidant's condition in the body, which leads to metabolic imbalance and leading to diseases. It is one of the main diseases around the world, affecting the human lifestyle, either psychologically and physically. The natural...

K. G. Sankar * and B. S. Venkateswarlu

Department of Pharmacognosy, MAM College of Pharmacy, Kesanupalli, Narasaraopet, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5059-63

5059-5063

62

43

36.

PRIMARY SCREENING FOR EXTRACELLULAR ENZYME PRODUCTION, POLY-HYDROXYBUTYRATE PRODUCTION AND SALT TOLERANCE BY BACTERIA ISOLATED FROM KUTCH REGION OF GUJARAT

Gujarat has the second largest mangrove ecosystem in India, and mangrove ecosystems are known for their extreme environments and hence extremophiles that can produce novel enzymes can be found in these extreme environments. In this study, ninety-three bacterial isolates were obtained in pure cultures from soil samples collected from Kandla, Mundra and Tuna of the Kutch region of Gujarat in the win...

A. S. Kharadi and F. R. Patel *

Department of Biotechnology and Microbiology, Shri M. M. Patel Institute of Sciences and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5064-70

5064-5070

58

36

37.

A COMPARATIVE EVALUATION OF ANTIPLATELET REGIMENS FOR PREVENTION OF RECURRENCE IN PATIENTS WITH ISCHEMIC STROKE – A PILOT STUDY

Background: Prevention of recurrence is important for patients with ischemic stroke. The purpose of the study was to compare the effectiveness of two antiplatelet regimens-aspirin plus clopidogrel versus aspirin plus cilostazol in early secondary stroke prevention using National Institutes of Health Stroke Scale (NIHSS) Scores. Methods: In this study, we randomly assigned 30 patients to receive as...

S. Farooqui *, S. Arfaa, S. Nousheen, S. Fatima and M. Zoheb

Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5071-75

5071-5075

71

34

38.

IN-VIVO ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT FROM ROOTS OF SMILAX CHINA ON ALUMINIUM CHLORIDE INDUCED OXIDATIVE STRESS IN WISTAR RATS

To examine the antioxidant property of ethanolic extract of roots of Smilax china (EESC) on Aluminium Chloride Induced oxidative stress in Wistar rats. The phytoconstituents are extracted from the roots of S. china using ethanol, by hot continuous percolation method. The rats were divided into 5 groups (6 animals/ group) and treated with EESC (150 & 300 mg/kg of body weight) and piracetam (0.5...

B. Sabarisenthil *, A. Yokeshwaran and V. K. Kalaichelvan

Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5076-80

5076-5080

62

40

39.

COMPARATIVE ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS, FREE RADICAL SCAVENGING ACTIVITY AND GC-MS ANALYSIS OF LEAF AND FLOWER EXTRACT OF TITHONIA DIVERSIFOLIA (HEMSL.) A. GRAY

The secondary plant metabolites possess therapeutic value, thus play a significant role in human health and general wellbeing. The present study aimed to estimate the secondary metabolite concentration and to evaluate the antioxidant potential of Tithonia diversifolia leaf and flower extract in methanol. The phytochemical compounds in the extracts were characterized through Gas Chromatography-Mass...

M. S. Roopa *, R. Shubharani, T. Rhetso and V. Sivaram

Department of Botany, Bangalore University, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5081-90

5081-5090

78

42

40.

AN EXPERIMENTAL STUDY TO EVALUATE ANTI-INFLAMMATORY ACTIVITY OF MURIVENNA IN WISTAR ALBINO RATS

Murivenna is a taila (oil) which is widely used in South-Indian practices for external application in many of the localized conditions such as trauma, inflammation of joint, fracture, joint dislocation, wound, etc. Taila (Oil) is considered best for vatahara action. Vata is the main dosha involved in shopha (inflammation); this is a suitable taila (oil) that works in the treatment of shopha (infla...

V. V. Nair, A. Mohanan and A. K. Mishra *

Department of Rasashastra and Bhaishajya Kalpana (Medicinal Chemistry and Pharmacy), Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5091-03

5091-5103

73

38

41.

IN-VITRO EVALUATION OF THE TOTAL PHENOLIC, FLAVONOID CONTENTS AND FREE RADICAL SCAVENGING POTENTIAL OF RUMEX HASTATUS

Objective: The aim of this study was to screen various solvent extracts of leaves of Rumex hastatus to display in-vitro antioxidant activity, total phenolic, and flavonoid contents in order to find possible sources for future novel antioxidants in food and pharmaceutical formulations. Materials and Methods: A detailed study was performed on antioxidant activity of various Rumex hastatus leaves ext...

K. K. Verma *, A. Choudhary, G. D. Gupta, R. K. Gautum, S. Singla and S. Goyal

Department of Pharmacology, School of Pharmacy, Abhilashi University, Mandi, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5104-11

5104-5111

56

35

42.

ETHNOMEDICINAL VALUES AND ANTIDIABETIC POTENTIAL OF CLERODENDRUM SPP. OCCURRING IN NORTHEASTERN REGION

The present study was undertaken to systematically analyze, document the traditional knowledge of Clerodendrum species use for the treatment of various human ailments from NER. The information was collected by literature survey as well as by consulting questionnaire with the villagers and local communities of NER. A total of twelve Clerodendrum species were collected, and among them, C. colebrooki...

J. Kalita *, S. S. Singh and M. L. Khan

Department of Biotechnology, Gauhati University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5112-24

5112-5124

54

30

43.

ANTIPLATELET AND ANTIHEMOLYTIC ACTIVITIES OF HYDROETHANOLIC EXTRACT OF ANNONA MURICATA LEAVES

This study designed to evaluate the antiplatelet and antihemolytic activity of hydroethanolic extract of Annona muricata leaves (HEEAM). The platelet aggregation assay was carried out using platelet-rich plasma, and the antihemolytic assay was done by hydrogen peroxide with different concentration of plant extract (100-500 μg/ml). HEEAM was found to possess more hydrogen donating ability when com...

N. Pichai and B. Durairaj *

Department of Biochemistry, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5125-28

5125-5128

62

36

44.

PROTECTIVE EFFECT OF AMARANTHUS SPINOSUS FOR ISCHEMIA REPERFUSION INJURY IN RAT BRAIN

Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demands. This leads to poor oxygen supply or cerebral hypoxia and thus leading to the death of brain tissues or cerebral infarction/ischemia stroke. It has been the third most common cause of death in developed countries; stroke can affect walking, talking, speech, vision, spatial awareness, s...

M. Abid * and N. A. Khan

Department of Pharmacology, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5129-34

5129-5134

58

38

45.

ASSESSMENT OF EPIDEMIOLOGY, PRESCRIBING PATTERNS, MEDICATION ADHERENCE AND IMPACT OF PATIENT EDUCATION ON DIABETICS IN A RURAL COMMUNITY

Background: There is a rise in a number of diabetes mellitus patients globally, but awareness of the disease, symptoms, medication use, associated complications, and comorbidities are low among Indians. The objective of the study was to evaluate the epidemiology of diabetes, prescribing patterns, and medication adherence and the impact of patient education on diabetes in a rural community. Methods...

D. Sharmila, T. B. Sri and S. T. K. Sridhar *

Department of Pharmacy Practice, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5135-41

5135-5141

54

31

46.

STUDIES ON PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL ACTIVITY OF LEAF EXTRACTS OF TERMINALIA TOMENTOSA WIGHT & ARN.

The present work aimed to screen the phytochemical constituents and antibacterial activity in leaves of different extracts of Terminalia tomentosa (Combretaceae). Phytochemical analysis was performed to check the presence of flavonoids, alkaloids, phenolic compounds, steroids, saponins, tannins, anthocyanins, lignins, and glycosides. The antibacterial activity of aqueous, ethanol and methanol extr...

V. A. Krishna *, A. Rekha and P. Sujathamma

Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5142-47

5142-5147

74

35

47.

COMPARATIVE MODELLING AND DOCKING STUDIES OF CYTOCHROME C OXIDASE SUBUNIT 1 PROTEIN

Cytochrome c oxidase, a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. It provides a critical function in cellular respiration in both eukaryotes and prokaryotes. The recent development in technology has enabled researchers to understand the genetic, molecular, structural, and functional properties of proteins to identify appropriate targets again...

V. Mallojala, K. Pasam, S. K. Gunda *, S. Bandi and M. Shaik

Bioinformatics Division, PGRRCDE, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5148-57

5148-5157

76

38

48.

CHEMICAL COMPOSITION AND PUPICIDAL ACTIVITY OF ESSENTIAL OIL FROM MENTHA SPICATA AGAINST AEDES AEGYPTIL. (DIPTERA: CULICIDAE)

Mosquito-borne diseases are serious health problems in India, and mosquito vector control is a fundamental approach to control various diseases. Essential oils represent eco-friendly alternatives to costly synthetic pesticides for mosquito control. The essential oil of Mentha spicata in India was used for its activity against Ae. aegypti. The essential oil showed pupicidal activity against this mo...

S. Paulraj *, T. Selvamohan and K. Kumaraswamy

Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5158-62

5158-5162

57

31

49.

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF DIOSPYROS EBENUM J. KOENIG EX RETZ., LEAVES EXTRACT

Phytochemical screening and antioxidant activities with different solvents extracts of Diospyros ebenum were investigated. The phytochemical screening of this study indicated the presence of alkaloids, carbohydrates, coumarins, flavonoids, glycosides, phenols, proteins, saponins, steroids, tannins, and terpenoids. The methanolic extract of D. ebenum was significantly higher phenolic content when c...

K. Vijayan *, M. Gopinathan and V. Ambikapathy

PG and Research Department of Botany, M. R. Govt. Arts College, Mannargudi, Thiruvaur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5163-69

5163-5169

81

37

50.

EVALUATION OF ORGANOLEPTIC, PROXIMATE PARAMETERS AND ANALYSIS OF NUTRITIONAL COMPOSITION OF FIVE WILD WEEDS: A SEARCH FOR LOW-COST NUTRACEUTICALS

Medicinal plants are the predominant source of phytochemicals and nutraceuticals, and it is used for the treatment of many diseases for its high effectiveness, low cost, and wide availability. In the current research study five, commonly used ethnomedicinal weeds of West Bengal, and India namely; Heliotropium indicum, Tridax procumbens, Cleome rutidosperma, Commmelina benghalensis, and Euphorbia h...

P. Ghosh and S. Chatterjee *

Department of Biotechnology, Techno India University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5170-81

5170-5181

61

38

51.

QUALIFICATION AND COMPUTER SYSTEM VALIDATION OF PHARMACEUTICAL INSTRUMENT: CRITICAL QUALITY ATTRIBUTES IN PHARMACEUTICAL INDUSTRY

Quality is the most important requirement in the manufacturing process for every pharmaceutical and healthcare industry. All the drugs must be manufactured to the highest quality level. Quality cannot be guaranteed just by end-product testing, but we have to control each critical step carefully during the manufacturing process. This qualification and computer system validation plays an important r...

S. Katre * and N. Jain

Department of Chemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5182-91

5182-5191

77

43

52.

MOLECULAR DYNAMICS INVESTIGATION FOR THE IMPACT OF METAKAOLIN ON MECHANICAL PROPERTIES OF THE ORDINARY PORTLAND CEMENT

The incorporation of Ordinary Portland cement with additional cementing materials is one of the most efficient methods to improve its microscopic properties. The aim of this work is to investigate the effect of metakaolin on Portland cement performance by using theoretical methods. 14 Å tobermorite was used as an alternative familiar molecular structure in representing Ordinary Portland cement. A...

R. K. Hussein *, A. T. Hassan and A. Alkaoud

Department of Physics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, KSA.

DOI: 10.13040/IJPSR.0975-8232.11(9).5192-97

5192-5197

67

34

53.

HPTLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND CELECOXIB IN PURE AND COMBINED DOSAGE FORM

HPTLC is simple, reliable, precise and accurate for separation and identification of drug in a combined dosage form which gives satisfactory accuracy in results when applied on amlodipine besylate (Amlo) and celecoxib (Celo). Toluene, ethyl acetate, methanol and conc. ammonia (6:5:1.5:0.3 v/v/v/v) was required as a mobile phase for separation and identification of drugs. These drugs were scanned b...

T. R. Mandale * and M. S. Kondawar

Department of Quality Assurance, ABCP, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5198-04

5198-5204

69

43

54.

MICROEMULSION GEL OF IRBESARTAN: A POTENTIAL TRANSDERMAL DELIVERY SYSTEM

The transdermal delivery route is increasingly being used for drug delivery primarily because the route avoids drawbacks encountered with oral and parenteral routes of drug administration. Irbesartan is an angiotensin II receptor antagonist used clinically to treat hypertension. The objective of the present study was to investigate microemulsion gel as a transdermal delivery system of irbesartan w...

C. M. Onah * and C. J. Mbah

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu State, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.11(10).5205-13

5205-5213

85

45

55.

PHYTOCHEMICAL ANALYSIS, ANTIBACTERIAL ACTIVITY AND ANTIOXIDANT ACTIVITY OF LEAF EXTRACTS OF MERREMIA EMARGINATA (BURM. F.)

Merremia emarginata is a creeping herb, rooting at nodes, and commonly used in folk medicine. The current study was undertaken with the aim of preliminary phytochemical analyses, evaluation of antimicrobial activity, and antioxidant activity by methanol and aqueous extracts of leaves of Merremia emarginata. The extracts were subjected to preliminary phytochemical analyses; Antibacterial activities...

S. Parkavi, P. Ganesh * and C. Swaminathan

Department of Microbiology, Faculty of Science, Annamalai University, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5214-18

5214-5218

74

43

56.

ISOLATION AND CHARACTERIZATION OF CHOLESTEROL OXIDASE FROM AMYCOLA-TOPSIS STRAIN USING 16S rRNA PARTIAL SEQUENCE

The aim of the present research work is to isolate and characterize microbial strain using partial sequencing of 16S rRNA gene region of Amycolatopsis strain K1. Five Amycolatopsis strains from soil samples were collected from the effluent sediments from Jajmau, Kanpur in U.P. India, and it was confirmed by polymerase chain reaction (PCR) that the isolates were different and not re-isolates of t...

A. Khan *, C. K. M. Tripathi and S. Kumar

Department of Biotechnology, Shri Ramswaroop Memorial University, Barabanki, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5219-24

5219-5224

98

37

57.

CHEMICAL PROFILE OF THE ANTIBACTERIAL COMPONENT FROM LEPTOLYNGBYA SP. HNBGU 002 ISOLATED FROM A HOT SPRING OF GARHWAL HIMALAYA

Cyanobacteria are a well-established source of antibacterial compounds. However, the hot spring cyanobacterial strains are not properly explored for the purpose. The study investigates the antibacterial potential of the thermophilic oscillatoriales isolated from a hot spring of Garhwal Himalaya. Out of 48 endo-metabolite pools, extracted from 16 thermophilic cyanobacterial strains, tested for anti...

S. Tyagi and R. K. Singh *

Cyano Biotech Lab, Department of Microbiology, H.N.B. Garhwal Central University, Srinagar Garhwal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5225-38

5225-5238

65

38

58.

BIORELEVANT DISSOLUTION METHOD DEVELOPMENT OF MEMANTINE EXTENDED-RELEASE CAPSULES FOR PREDICTION OF PRE-PRANDIAL IN-VIVO PERFORMANCE

The main objective of this research work is to develop biorelevant dissolution method for the Memantine extended-release capsule by correlating pre-prandial in-vivo performance. The mean plasma concentration profile obtained after oral administration of extended-release capsules was deconvoluted using the Wagner-Nelson deconvolution technique for deriving the percentage fraction of drug absorbed t...

D. Thamizhanban *, G. T. Rani and K. Krishnasamy

Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5239-46

5239-5246

63

35

59.

IN-SILICO MODELLING STUDIES ON RITONAVIR AND LOPINAVIR TO COMBAT COVID-19

The coronavirus is a group of families that cause respiratory problems in mammals, which consists of MERS (Middle East Respiratory Syndrome), SARS (Severe Acute Respiratory Syndrome), and COVID-19. The virus attaches to the ACE-2 receptor present in the epithelial cell of the lungs in the infected patients, and the infection may lead to fibrosis if not treated. The size of the genome may vary from...

J. S. Tuteja * and K. Chitnis

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5247-53

5247-5253

63

36

60.

DESIGN AND PHARMACOKINETIC EVALUATION OF IBRUTINIB BY SELF-NANO-EMULSIFYING DRUG DELIVERY SYSTEM

The objective of present research work is design and in-vivo evaluation of ibrutinib self-nanoemulsifying drug delivery system (SNEDDS) for the enhancement of oral bioavailability. Box-Behnken design was used for the study and the results analysed using response surface methodology. Ibrutinib SNEDDS were prepared with various oils, surfactants and co-surfactants and tested particle size, PDI, zeta...

D. Prasad *, G. P. Mohanta and M. Sudhakar

Mallareddy College of Pharmacy, Department of Pharmaceutics, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5254-61

5254-5261

64

33

61.

IN-VIVO AND IN-VITRO ANTIASTHMATIC STUDIES OF PLANT MICHELIA CHAMPACA LINN.

Michelia champaca known as champaca is belonging to family of Magnoliaceae. The present work consist of extraction and evaluation of anti-asthmatic activity of flowers of Michelia champaca Linn. Flowers was evaluated for anti-histaminic activity using isolated goat tracheal chain preparation and histamine induced Broncho-constriction in Albino mice. Michelia champaca Linn. expressively inhibited d...

S. R. Shejale * and V. C. Yeligar

Department of Pharmaceutical Chemistry, Ashokrao Mane College of Pharmacy, Peth – Vadgaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5262-67

5262-5267

54

34

62.

IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM RHIZOPHORA MUCRONATA METHANOLIC LEAF EXTRACT BY GC-MS ANALYSIS

Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat vari...

X. A. Mary *, M. S. Ali, V. Anuradha and M. Moorthi

Post Graduate & Research Department of Biotechnology, Mohamed Sathak College of Arts & Science, Sholinganallur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5268-72

5268-5272

34

23

63.

MASS SPECTROMETRIC IDENTIFICATION OF SECONDARY METABOLITES FROM MARINE SEAGRASS – CYMODOCAEA SERRULATA (R. BROWN) ASCHERSON & MAGNUS AND ITS ASSOCIATED BACTERIA BACILLUS CEREUS

A marine sea-grass Cymodocaea serrulata was collected, dried and extracted with a different solvent. The presences of phytochemical constituents were confirmed and the ethyl acetate extraction was considered to be a suitable solvent. In addition, the crude seagrass was serially diluted and spread onto the Zobell Marine Agar plates. Among the eight colonies obtained, the red-pigmented bacterium (CS...

R. Sivaramakrishnan, S. Suruthi and M. Arumugam *

Faculty of Marine Science, CAS in Marine Biology, Annamalai University, Parangipettai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5273-83

5273-5283

24

18