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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 11 (2020) - Issue 12, December

Review Articles

 
Title
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1.

NUCLEAR MAGNETIC RESONANCE AND HYPHENATIONS – A REVIEW

Nuclear magnetic resonance spectroscopy is an absorption spectroscopic technique that helps in structural elucidation and has a wide range of applications in various fields like drug discovery and development, metabolomics, combinatorial chemistry, and food sciences. This paper gives information about nuclear magnetic resonance spectroscopy, and clear description of LC-NMR-MS, and a brief descript...

S. Gummadi * and D. S. Siyyadri

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5932-50

5932-5950

1414

942

2.

A REVIEW OF RECENT ADVANCES IN POLYMERIC SHAPE MEMORY HYDROGEL

In Today’s world, there are many drug delivery systems available but there are many problems related to drug delivery systems like stability, degradation in-vivo. Drug delivery through tablets is the most convenient method due to patient compliance. Recently, hydrogels are hydrophilic 3-dimensional polymeric structures that have been explored by researchers due to their extraordinary promising p...

S. Kaur * and P. Gaba

Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5951-67

5951-5967

1071

646

3.

PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF MORINGA OLEIFERA LAM.

Moringa oleifera, a miracle plant, is praised for beneficial health nutrients and has potential cholesterol-lowering activity. Almost all the parts of the Moringa oleifera plant have potential bioactivity. The main active constituents of Moringa oleifera are flavonoids, alkaloids, phenols, vitamins, minerals, proteins, glycosides, Glucosinolates and Isothiocyanates, terpenes, saponins, tannin...

P. Jain, N. Jain and U. K. Patil *

Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5968-73

5968-5973

2053

784

4.

A NOVEL APPROACHES FOR DRUG DEVELOPMENT AND PHARMACOLOGICAL STUDY OF HERBAL PLANT

From ancient times, herbal medicines are in use to cure the diseases due to their impending and less side effects. But complications in identification, processing, standardizing, extracting of herbal drugs, it seldom attracts scientists towards the development of novel delivery systems for herbal drugs. During drug development, the complete knowledge of novel scientific approaches like toxicity st...

H. Pandey, S. Srivastava and Y. B. Tripathi *

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Banaras, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5974-86

5974-5986

1162

631

5.

REVITALIZING RATIONALITY THROUGH PDAA CYCLE-A UNION THERAPY CONCEPT

Medicine has been a noble profession since time immemorial. Many cultures have the view that it is linked with the supernatural deity. The persons were priests in many civilizations. They had high status in Society. They were considered as a medium of communication between the supernatural and were assumed to have powers. In those times, those priests used rituals and follow some religious code of...

K. Kala * and R. K. Sodhi

IK Gujral PTU (IK Gujral Punjab Technical University, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5987-94

5987-5994

930

490

6.

AN ANALYSIS OF PHARMACOLOGICAL ACTIVITIES OF PORTULACA OLERACEA

Portulaca oleracea belonging to the family Portulacaceae has a wide occurrence throughout the World. It has numerous nutritional and medicinal benefits to humans because it is a good source of many minerals, vitamins, fatty acids, alkaloids, flavonoids, aspartic acid, coumarins, glutathione, etc. It is used in the traditional system of medicine in many countries like India, Nigeria, Palestine, Chi...

H. Kaur

Department of Botany, Government College for Girls, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5995-04

5995-6004

693

394

7.

TEFF MILLET: NUTRITIONAL, PHYTOCHEMICAL AND ANTIOXIDANT POTENTIAL

Teff millet is progressively gaining importance worldwide due to its recognition as gluten-free food. Interestingly, its attractive nutritional profile and additional functions related to maintaining health play an important role in its identification as a nutraceutical food. The present study was conducted to analyze the nutritional, phytochemical, and antioxidant properties of teff millet. Moist...

Akansha and E. S. Chauhan *

Department of Food Science and Nutrition, Banasthali Vidyapith, Vanasthali, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6005-09

6005-6009

672

371

8.

ORAL STRIPS: A NOVEL DRUG DELIVERY TECHNOLOGY

In the development of a new drug molecule, there are many problems with respect to the dissolution, absorption, and bioavailability. Thus, formulation scientists are majorly focusing on the development of the formulation, which will increase the efficacy of the existing drugs. Oral dispersible films are one of such a novel approach. In given review article, the advantages of oral dispersible films...

A. Karandikar, V. Kedar and C. Surve *

Department of Pharmaceutics, Vivekanand Education Society’s College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6010-19

6010-6019

1483

478

9.

PHARMACOLOGICAL ACTIVITIES OF MUNTINGIA CALABURA: AN OVERVIEW OF THE LAST LUSTRUM

Background: In honor of a dutch botanist, Abraham Munting, the tree was named Muntigia calabura L. The Jamaica cherry, M. calabura is a shrub or tree which is native to Jamaica, Brazil, Mexico, and North America. M. calabura is a well-known, fast-growing tree clasped with different medicinal and health benefits. Different parts of the tree are being used for various ailments in different parts of ...

R. Narendra and Y. Jyothi *

Department of Pharmacology, Krupanidhi College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6020-27

6020-6027

771

425

10.

NOVEL STRATEGY FOR IMPROVING BIOAVAILABILITY OF OCULAR DRUG DELIVERY USING COLLOIDAL NANOSUSPENSION

Nowadays, a very large proportion of new drug candidates arising from drug discovery programs are water-insoluble and, for that reason, poorly bioavailable. The trouble is even more complex for drugs that belong to the BCS Class II category. To overcome these problems, nanotechnology is used to enhance the solubility as well as bioavailability of poorly soluble drugs. In the ocular drug transport ...

R. Kalita * and B. Das

Girijananda Chowdhury Institute of Pharmaceutical Science, Affiliated to Assam Science and Technology University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6028-37

6028-6037

771

401

11.

A REVIEW ON ELECTROPHORESIS, CAPILLARY ELECTROPHORESIS AND HYPHENATIONS

Electrophoresis is an effective analytical tool for separation, as it does not affect the molecular structure, and it is also highly sensitive to small differences in molecular charge and size of the analytes. Capillary electro-phoresis is a separation technique where the ions are separated based on their electrophoretic mobility with an applied voltage. So far, the research field of capillary ele...

S. Gummadi * and V. N. Kandula

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6038-56

6038-6056

4031

865

Research Articles

 
Title
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Cited
12.

HEPATOPROTECTIVE EFFECT OF EUGENIA UNIFLORA ACTIVE FRACTION AGAINST CCL4 INDUCED HEPATOTOXICITY IN MALE WISTAR RATS

Eugenia uniflora known as pitanga or Surinam cherry, belongs to the Myrtaceae family and has essential nutrients that are prerequisites for human health. In the present study, Eugenia uniflora active fraction (EF18) that was obtained from the partial purification of crude ethanolic extract of Eugenia uniflora leaves were evaluated for its carbon tetrachloride (CCl4) induced liver toxicity in rats....

S. Syama, L. R. Helen and M. S. Latha *

Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6057-66

6057-6066

1038

595

13.

DISEASE MODIFYING POTENTIAL OF WEDELOLACTONE RICH FRACTION OF ECLIPTA ALBA IN ADJUVANT INDUCED ARTHRITIS IN RATS BY INHIBITION OF PRO-INFLAMMATORY CYTOKINES

Eclipta alba (Family-Asteraceae) is a herb commonly used in traditional Ayurvedic medicine for the treatment of inflammation, pain, and wounds. The present study is aimed to validate the ethnobotanical use of Eclipta alba in an animal model. The animals were induced with arthritis by injection of FCA on day 0 and treated with wedelolactone rich fractions of Eclipta alba (100, 200 and 400 mg/kg) fr...

B. N. Atre, S. Arulmozhi *, L. Sathiyanarayanan, V. V. Dhapte and K. R. Mahadik

Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6067-77

6067-6077

975

518

14.

ANTIDIABETIC EFFECT OF ETHANOLIC LEAVES EXTRACTS OF AZIMA TETRACANTHA LAM. IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Objective: The goal of the present examination was to investigate anti-diabetic activity of Azima tetracantha Lam. leaves in streptozotocin-induced diabetic rats. Materials and Method: At a regular interval of an experimental protocol, blood glucose, insulin, glycogen, HDL, LDL, VLDL, FFA, PL, and TC and organs to bodyweight proportion were assessed in streptozotocin-induced diabetic rats. Histolo...

S. Josephinol * and T. N. Begum

Department of Biochemistry, Holy Cross College, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6078-85

6078-6085

982

575

15.

C-TERMINAL CLAW STABILISATION IN CORVUS AVIAN BETA DEFENSIN 7 AND ITS MUTATION STUDIES

Antimicrobial peptides are considered as promising and potential next-generation antibiotics on account of their broad spectrum of antimicrobial activity and unique mode of microbial killing. For therapeutic application, it is essential to consider the hemolytic or cytotoxic property of AMPs along with antimicrobial function. In the current study, an avian beta-defensin 7 (AvBD7) gene was identifi...

K. Shalini, G. K. Prasanth, K. Arvind and T. Grace *

Department of Genomic Science, School of Biological Sciences, Central University of Kerala, Kasaragod, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6086-96

6086-6096

970

473

16.

EXPLORATION OF AMORPHOPHALLUS PAEONIIFOLIUS STARCH AS NATURAL BINDER

The aim of the present work was to characterize the starchy components of Amorphophallus paeoniifolius tuber and evaluate its potential as a binder. The tuber starch was extracted and characterized in terms of Phyto-chemical and physicochemical properties. Cyproheptadine was selected as model drug, and drug excipient compatibility studies were carried. Granules containing 5%, 7.5%, 10%, and 12.5% ...

U. Y. Kandekar * and T. R. Abhang

JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathwade, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6097-04

6097-6104

940

553

17.

STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAUNORUBICIN AND CYTARABINE

The main objective of the study was to develop an RP-UPLC method for the simultaneous determination and validation of the Daunorubicin and Cytarabine in the pharmaceutical dosage form. The technique was developed by using the Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile used in the ratio 50:50 v/v and X-Bridge C18 (2.1 × 100 mm, 1.6 µm) as a stationary phase at a flow rate of 0.3 ml...

Y. N. Reddy and J. Sreeramulu *

Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6105-13

6105-6113

529

370

18.

FORMULATION, NUTRITIONAL, SENSORY, ANTIOXIDANT ACTIVITY AND SHELF LIFE STUDIES OF INSTANT SOUP MIX

In today’s modern lifestyle, there is an increase in the development of various instant food products. To meet consumer requirements, the food choice will depend on several factors. The present study was aimed with the objective to formulate a value-added instant soup mix with nutritional and sensory charac-teristics. Further, the prepared instant soup mix was subjected to antioxidant and shelf ...

Priti and K. Prameela *

Department of Biotechnology, GITAM Institute of Technology, GITAM University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6114-23

6114-6123

1001

381

19.

PHYLOGENETIC CHARACTERIZATION OF POTENTIAL BIOACTIVE METABOLITES PRODUCING ACTINOMYCETES FROM MANGROVE SEDIMENTS

An attempt has been made in the present study to isolate and identify actinomycetes, which can produce bioactive metabolites possessing antimicrobial activity. The soil samples were collected from mangrove sediments of Krishna district, Andhra Pradesh. The potent secondary metabolite producing strains were isolated and designated as VLK-15, VLK-24, and VLK-56. Identification of the strains was car...

K. Naragani *, M. D. Indupalli and V. Muvva

Department of Botany, PB Siddhartha College of Arts & Science, Vijayawada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6124-29

6124-6129

482

332

20.

APPLICATION OF BIOANALYTICAL METHOD IN PHARMACOKINETIC STUDIES OF DIKAMALI GUM BASED MICROSPHERES OF FLURBIPROFEN FROM RABBIT BLOOD SAMPLES

Preparation and evaluation of dikamali gum-based microspheres of Flurbiprofen, needed a suitable bioanalytical method. In this direction, we report the development of a simple RP-HPLC method for the determination of Flurbiprofen in rabbit plasma samples by using the standard internal method. The method was carried out on RP C18 column, with a mixture of the buffer: acetonitrile (60:40) as the mobi...

K. L. Deepthi *, G. V. Radha, G. Vineetha, M. S. Lakshmi and P. Indira

Department of Pharmaceutical Technology, Raghu College of Pharmacy, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6130-34

6130-6134

453

299

21.

AMELIORATIVE POTENTIAL OF AQUEOUS EXTRACT OF MORINGA OLEIFERA LEAF AGAINST IMIDACLOPRID INDUCED HEPATOTOXICITY IN ZEBRA FISH, DANIO RERIO

The current study was aimed to estimate the ameliorative potential of Moringa leaf extract (MLE) against the toxicity of Imidacloprid (IMC) on hepatic biomarkers in zebra fishes, Danio rerio after acute exposure. To analyze liver biomarkers, 20 fishes were randomly selected and divided into four groups. Group- I served as control, Group- II received MLE- 12 ml/l , Group III- treated with 24 h LC50...

V. Yadav *, S. Ahmad and K. Zahra

Department of Zoology, Bipin Bihari P.G. College, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6135-42

6135-6142

537

333

22.

A STUDY ON TERNARY MIXTURE OF PEPTIDE USING ULTRASONIC, IN-VITRO AND IN-SILICO PROCESSES

Penetrating biomolecules by ultrasonic techniques is an innovative and influential tool for characterizing their physicochemical properties. Peptides have been used as extensive applications in drug construction and as an ingredient in nutritional complements. An investigation based on the behavior of promulgation of ultrasonic waves in solids and the liquid system is now rather well recognized as...

R. Padmavathy *, K. Dhanalakshmi and R. Geetha

PG & Research Department of Physics, Seethalakshmi Ramaswami College, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6143-48

6143-6148

416

297

23.

A COMPARATIVE EVALUATION OF PERMEATION ENHANCERS FOR ROPINIROLE HYDROCHLORIDE A BCS CLASS III DRUG TO BE FORMULATED AS TRANSDERMAL DRUG DELIVERY SYSTEM

Ropinirole hydrochloride, a non-ergoline dopamine agonist, administered orally for the treatment of Parkinson's disease and restless leg syndrome and belonged to BCS class III drug having high solubility and low permeability. The objective of the present research study was to enhance the permeability of ropinirole hydrochloride by selecting a suitable permeation enhancing agent from different clas...

R. Sadashivaiah, B. K. S. Babu * and G. Rohith

Department of Pharmaceutics, Government College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6149-56

6149-6156

813

360

24.

AN ACUTE ORAL TOXICITY STUDY OF T-AYU-HM PREMIUM TABLET IN RATS: AN INITIATIVE FOR SICKLE CELL ANEMIA MANAGEMENT

Sickle cell anemia is a major life-threatening hemoglobin disorder in the world. This hemoglobin disorder is an autosomal recessive type, therefore considered as a major health problem in the world. The pain symptoms and complications of sickle cell anemia can be life-threatening many times. Management of sickle cell anemia demands drugs to be safe, well-tolerated, lesser side effects, and effecti...

A. M. Desai *, H. Desai, C. Desai and M. Patel

Dhanvantari Clinic, Ayurveda Health Care and Research Center, Shreeji Desai Market, Vyara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6157-60

6157-6160

674

330

25.

EVALUATION OF ANTI-IMPLANTATION ACTIVITY OF THESPESIA POPULNEA (L.) IN WISTAR ALBINO RATS (RATTUS NORVEGICUS)

The present study describes the anti-implantation activity of Thespesia populnea bark extracts (ethanol, ethyl acetate, and aqueous)on female albino rats. Extracts were tested for possible anti-implantation activity in albino female rats of the proestrus cycle after overnight cohabitation with males of proven fertility. The drugs were administered to pregnant female rats from day 1 to 7th day of p...

G. Priya and K. Saravanan *

Department of Zoology, Nehru Memorial College (Autonomous), Puthanampatti, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6161-65

6161-6165

528

304

26.

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF FAST DISINTEGRATING TABLET OF AMLODIPINE BESYLATE BY USING SUPERDISINTEGRANTS PLANTAGO OVATA AND LOCUST BEAN GUM

The objective of the present study was to develop and characterize the fast disintegrating tablets, which rapidly disintegrates in the sublingual area without the need of water or with a little amount of water. Amlodipine besylate is a calcium channel blocker (long-acting) basically used in the treatment of angina and hypertension for immediate relief in life-threatening conditions. In this work, ...

H. Singh *, A. Majumdar, N. Malviya and S. Saxena

Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6166-72

6166-6172

499

319

27.

RECUPERATION OF DIABETES INDUCED OXIDATIVE DAMAGE IN LIVER BY TREATMENT WITH CURCUMIN IN STZ INDUCED DIABETIC RATS

The aim of the present study was to investigate the effect of Curcumin on blood glucose levels, body weight changes, and oxidative stress markers in the diabetic rat liver. Diabetes exacerbates hepatic injury induced by hyperglycemia mediated oxidative stress. A marked decrease in the blood glucose levels, body weight changes and anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (C...

S. N. Shameer * and D. Sudhakar

Department of Zoology & Biotechnology SGS Arts College (TTD) Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6173-78

6173-6178

495

311

28.

SIMULTANEOUS ESTIMATION OF DAPSONE AND ADAPALENE IN GEL FORMULATION BY UV- SPECTROSCOPY

Objective: A new, simple, sensitive, and economical UV spectro-photometric method was developed for the simultaneous analysis of Adapalene and Dapsone in pharmaceutical formulation. Method: This UV method was developed with Tetrahydrofuran and Distilled water as solvents. The wavelengths selected for analysis in the present method were 237 nm and 293 nm. The method was validated as per ICH guideli...

V. S. Vichare * and P. V. Handargule

PES Modern College of Pharmacy (for Ladies) Moshi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6179-83

6179-6183

699

335

29.

GC-MS ANALYSIS AND ANTI-INFLAMMATORY ACTIVITY OF MUREX TRIBULUS

The aim of this study was to screen the presence of bioactive compounds through GC-MS analysis and carry out the ant-inflammatory test of the methanolic tissue extract of Murex tribulus, a spiny predatory gastropod that is widespread from the Central Indian Ocean to Western Pacific Ocean. The GC-MS analysis of the methanolic flesh extract revealed the presence of four bioactive compounds, 1, 2 dim...

J. E. Mereen * and J. H. J. Diaz

Department of Zoology, St. Mary’s College (Autonomous), Thoothukudi, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6184-88

6184-6188

574

319

30.

CHEMOPREVENTIVE POTENTIAL OF CAPPARIS DECIDUA FRUIT EXTRACT AGAINST DMBA INDUCED SKIN CARCINOGENESIS IN SWISS ALBINO MICE

Chemoprevention is the novel approach that inhibits and delays or reverses the process of cancer development by using natural herbs and plant products. The aim of the present study was to evaluate the anticancer efficacy of orally administered Capparis decidua fruit extract (CDE) on skin carcinogenesis model in swiss albino mice by the single topical application of the 7,12 dimethylbenz (a)anthrac...

Devki, R. Vyas and R. Sisodia *

Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6189-97

6189-6197

480

312

31.

DESIGN SPACE EVALUATION OF FORMULATION AND PROCESS VARIABLES OF REPAGLINIDE TRANSDERMAL THERAPEUTIC SYSTEM

Repaglinide, a blood-glucose-lowering drug, has low oral bioavailability (56 %) due to first-pass metabolism and shorter half-life (~1 hour) lead to frequent dosing to control blood glucose level. Repaglinide Transdermal Therapeutic System (TTS) was prepared to provide continuous drug delivery for a prolonged period of time. Factors affecting critical quality attributes (CQA) of Repaglinide TTS ar...

D. Pethani * and S. Prajapati

Department of Pharmaceutical Sciences, Hemchandracharya North Gujarat University, Patan, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6198-06

6198-6206

589

332

32.

FABRICATION AND EVALUATION OF ELASTOSOMES OF BOSWELLIA SERRATA FOR TRANSDERMAL DRUG DELIVERY

The extracts of Boswellia serrata possess notable medicinal uses. Boswellia serrata is a highly lipophilic drug. It undergoes extensive hepatic first-pass metabolism. The t1/2 is approximately 6 h. There are reported side effects with the administration of Boswellia serrata. This research work aims to fabricate Elastosomes which get hold of many desired features for transdermal drug delivery. The ...

N. P. Griddaluru * and A. Uppala

Department of Industrial Pharmacy, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6207-12

6207-6212

521

340

33.

ISOLATION AND CHARACTERIZATION OF SOME PHYTOCHEMICAL COMPOUNDS FROM THE METHANOLIC EXTRACT OF SOLANUM TORVUM SWARTZ FRUITS

Solanum torvum Sw. belonging to the family Solanaceae is locally called as pea eggplant, sundai and cherry egg-plant in India. The fruits of Solanum torvum Sw. used to cure diseases of the diuretic, malaria, stomach aches, problems with the spleen, treat coughs, improve the eyesight, treats headaches which attribute many properties in Ayurveda, siddha, unani and local health traditions. The purpos...

P. Pratheema *, L. Cathrine and S. Gurupriya

PG and Research Department of Chemistry, Holy Cross College, Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6213-21

6213-6221

633

353

34.

IMPACT OF SOCIO-DEMOGRAPHIC FACTORS ON THE BONE IN DIABETIC OSTEOPOROSIS POSTMENOPAUSAL WOMEN

Background: Diabetic postmenopausal women and osteoporosis are both chronic conditions and the relationship between them are complex. Objective: The aims of this study were to assess the socio-demographic factors inflicted in Diabetic postmenopausal women with Osteoporosis condition. Method: A Prospective, comparative and interventional study with a convenient sample of 520 Diabetic postmenopausal...

P. K. Tirupathi *, C. K. Dhanapal , S. Muvvala, D. S. S. P. Pratap, S. Bejugam and K. S. V. P. Raghavendra

Department of Pharmacy Practice, Malla Reddy Hospital, Secunderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6222-26

6222-6226

417

297

35.

EVALUATION OF SYNERGIC ANTIDEPRESSANT ACTIVITY OF NARDOSTACHYS JATAMANSI WHEN GIVEN ALONG WITH IMIPRAMINE IN WISTER ALBINO RATS AND SWISS ALBINO MICE

Background: Depression is affecting around 5% of the population. In the traditional systems of medicine, many plants and formulations have been used to treat depression for thousands of years. Objectives: This study evaluated the synergic effect of Hydro-alcoholic extract of Rhizomes of Nordostachys jatamansi DC Per Se with combination with Imipramine in Wistar, albino rats, and swiss albino mice ...

N. N. Goswami * and R. Panchal

Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6227-31

6227-6231

485

311

36.

DNA INTERACTION STUDIES BY UV OF COPPER COMPLEX BASED ON HETEROCYCLIC CHALCONES

Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants. Chalcone metal complexes and their derivatives have been known over the past fifty years. Copper is an...

M. M. Maste *, V. Hegde, S. M. Desai, A. Saxena, P. Inamdar and P. Debnath

Department of Pharmaceutical Chemistry, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6232-36

6232-6236

569

323

37.

STANDARDIZATION OF AYURVEDIC FORMULATION “ARJUNARISHTA” IN TERMS OF PHYSICOCHEMICAL, SPECTROSCOPY AND CHROMATOGRAPHIC TECHNIQUES

Objective: Arjunarishta is an important Ayurvedic formulation with chief ingredient Arjuna (Terminalia arjuna), which is excellent “Hrudya” Dravya. It nourishes & strengthens heart muscles & promotes cardiac functioning by regulating blood pressure and cholesterol level. This study aims to established quality parameters for standardization of Ayurvedic formulation “Arjunarishta” on...

K. S. Thakur *, P. Patil and M. Gawhankar

Shree Dhootapapeshwar Limited, Veer Sawarkar Chowk, Panvel, Raigad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6237-42

6237-6242

689

313

38.

SHORT TERM (21 DAYS) TOXIC IMPLICATIONS OF PERMETHRIN ON REPRODUCTIVE TISSUES OF MALE SWISS ALBINO MICE

Permethrin, a member of one of the newest class of insecticides, the synthetic type-I pyrethroids, is very much in use nowadays. Due to its relatively low mammalian toxicity and high photostability, it has earned great popularity. Several reports suggest its endocrine disrupting activity, damaging effect on nervous system, its receptors, and other adverse effects. However, very limited information...

Z. Siddiqui, N. Agravat, H. N. Highland and K. R. Desai *

Department of Zoology, BMT & HG, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6243-50

6243-6250

426

313

39.

FORMULATION AND EVALUATION OF MEDICATED ORAL JELLY OF TRAZADONE HYDROCHLORIDE

The objectives of the present investigation were to formulate and evaluate of Medicated oral jelly containing Trazadone HCl for the treatment of depression. Many psychotic patients are medicinal phobic who are afraid of taking medicine, so this preparation is most beneficial over that type of fear. Trazadone HCl antidepressant drugs incorporate in jelly and give to those patients; in this way, we ...

V. S. Kadam *, J. Kendre, G. R. Shendarkar and S. S. Kadam

Department of Pharmaceutics, Kandhar College of Pharmacy, Kandhar, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6251-59

6251-6259

884

341

40.

ROLE OF MRP–1 IN THE REGULATION OF STEROID RESPONSIVENESS IN UNCONTROLLED ASTHMA

Introduction: Inhaled Corticosteroids remain the mainstay therapy for asthma. Uncontrolled asthma (UA) dose not respond to the highest inhaled corticosteroids, which remains a challenge for clinicians. Multidrug resistance-associated protein 1 (MRP-1) are molecular "pumps," which expel toxins and modulate corticosteroids' pharmacokinetics and may lead to UA. Moreover, their role in UA is still not...

R. Mishra, Z. Hashim, A. Nath, H. Singh, V. Agarwal and R. Chaturvedi *

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6260-66

6260-6266

477

258

41.

ESTIMATION OF PERINDOPRIL ARGININE, INDAPAMIDE AND AMLODIPINE IN BULK AND FIXED DOSE COMBINATION USING STABILITY INDICATING REVERSE PHASE HIGH-PRESSURE LIQUID CHROMATOGRAPHY

A simple, accurate, and precise stability-indicating reverse phase high pressure liquid chromatographic method was developed and validated for the estimation of Perindopril arginine, Indapamide, and Amlodipine in the bulk and pharmaceutical dosage form. Chromatographic separation was carried out on ZORBAX RX C8 (250 mm × 4.6 mm, 5 µm) as a stationary phase with a mobile phase of gradient system ...

B. R. Chaudhary * and J. B. Dave

SAL Institute of Pharmacy, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6267-78

6267-6278

689

259

42.

EVALUATION OF PROMISING ANTIOBESITY ACTIVITY OF ETHANOLIC EXTRACT OF NIGELLA SATIVA SEED ON HIGH FAT DIET-INDUCED OBESE RATS

Nigella sativa (N. sativa) (Family Ranunculaceae) is a widely used medicinal plant throughout the world. Seeds and oil have a long history of folklore usage in various systems of medicines and food. Extensive studies of literature has been revealed that N. sativa has to carry antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato...

P. Saiju, A. Sharma, R. Jain and N. Jain *

Sagar Institute of Research Technology & Science-Pharmacy, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6279-88

6279-6288

421

229

43.

DoE ASSISTED UV-VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT FOR CRITICAL FACTOR ESTIMATION INVOLVED IN NORFLOXACIN DEGRADATION

Degradation studies are essential to determine the inference of degradation routes and stability of pharmaceuticals at different stress conditions. Norfloxacin is an extensively used antibiotics; hence, it is also commonly found in wastewater effluent. For proper risk assessment of norfloxacin and for better understanding of the factors involved in its environmental fate, different factors were st...

R. Singh, J. Upadhyay * and D. Singh

University of Petroleum and Energy Studies, Department of Pharmaceutical Sciences, School of Health Sciences, Bidholi, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6289-96

6289-6296

402

245

44.

TO DISCERN AND DERACINATE THE ACTIVE CONGLOMERATE FROM HERBS IN ANTAGONISM TO FOOD POISON EFFECTUATE S. AUREUS – AN IN-VITRO PHYTOTHERAPY

Medicinal plants are widely used to treat disease in non-industrialized societies for not being far cheaper than modern medicines. In this study, five types of medicinal plants viz., Glycyrrhiza glabra, Aegle marmelos, Centella asiatica, Cinnamomum verum, Cynodon dactylon were collected from Alwarkurichi, Tirunelveli District, Tamil Nadu, and extracts were prepared using various solvents such as m...

V. P. Kumar, R. S. Priyengha, Y. S. Alexander and S. Umamaheswari *

Department of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6297-04

6297-6304

420

239

45.

PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND CARBOHYDRATE DIGESTING ENZYME INHIBITORY POTENTIAL OF LEUCAENA LEUCOCEPHALA LEAVES EXTRACT

The study aims to investigate the antioxidant and antidiabetic activity of Leucaena leucocephala ethanol leaf extract (LLME). L. leucocephala leaves extraction was carried out by the maceration method. Phytochemical analysis was performed using standard analytical procedures. Diphenyl picrylhydrazyl (DPPH) radical and 2, 2’-azinobis (3-ethylbenzathiazoline-6-sulfonic acid) (ABTS) radical scaveng...

S. Chigurupati

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah, Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(12).6305-10

6305-6310

616

265

46.

IN-SITU GEL BASED MUCOSAL SITE-SPECIFIC DRUG DELIVERY SYSTEMS: FORMULATION AND EVALUATION

The aim of this study was to prepare a suitable mucoadhesive in-situ gel formulation of clotrimazole for the treatment of vaginal candidiasis. The in-situ gel-forming systems are viscous liquids that turn to a gel phase upon exposure to physiological conditions. The lower retention of conventional formulations in the vagina, mucoadhesive formulations would prolong the retention time.  For this st...

K. R. Patel *, H. R. Patel and N. H. Patel

Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar, Kherva, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6311-22

6311-6322

495

262

47.

HIGHLY BIOACTIVE ULTRA SMALL VANCOMYCIN DOPED SILVER NANOPARTICLES GROWN BY SOL-GEL METHOD

Highly bioactive ultra-small vancomycin doped silver nanoparticles were synthesized by the sol-gel method. The samples were characterized by UV, FR-IR, XRD, Photoluminescence, and TEM analysis. Continuous stirring helped in preparing ultra-small drug conjugate silver nanoparticles. Observation of weak (broadened peak) in XRD diffractograms indicates the formation of very small size drug conjugate ...

S. Rai and R. Kothari *

ITM University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6323-32

6323-6332

347

242

48.

PARTIAL CHARACTERIZATION, CYTOTOXIC AND GENOTOXIC PROPERTIES OF GLYCOPROTEINS FROM SYZYGIUM CUMINI LAM. SKEELS (BLACK PLUM)

In nature, lectins or glycoproteins are ubiquitous, abundantly distributed. Lectinsplayan an important role in plant defense mechanism against microorganisms. This fact has greatly attracted many research groups working in the field of biotechnology, agriculture, and medicine. Jamun or black plum is a fruit with many health benefits. This paper focuses on the phytochemical investigation of trichlo...

H. S. Nandini, N. Prabhudas, A. V. M. Kutty, P. R. Krishnaswamy and P. Kiranmayee *

Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6333-41

6333-6341

410

241

49.

GC-MS ANALYSIS AND IDENTIFICATION OF PHYTOCONSTITUENTS FROM HEXANE EXTRACTS OF ADHATODA VASICA NEES AND ADHATODA BEDDOMEI CB CLARKE LEAVES

The medicinal plants, Adhatoda vasica, and Adhatoda beddomei are commonly used in the treatment of several illnesses and respiratory disorders viz., cold, severe cough, chronic bronchitis, asthma and tuberculosis. The present study aimed to identify the phytochemical constituents and quantification of bioactive contents of hexane extracts of these plants, followed by metabolic fingerprinting, whic...

N. Sundaresan and I. Kaliappan *

Interdisciplinary Institute of Indian System of Medicine (IIISM), Institute of Indian System of Medicine, Kattankulathur, Chengalpattu, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6342-49

6342-6349

728

268

50.

PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT ACTIVITY ANALYSIS IN LEAF EXTRACT OF WATER APPLE [SYZYGIUM AQUEUM (BURM. F) ALSTON]

Syzygium aqueum is a well-known edible fruit-bearing plant species. The tribal people in Malaysia used different parts of the plant to cure various ailments. The previous studies on phytochemical evaluation of S. aqueum are very limited. The present study aims to conduct a detailed investigation of phytochemicals present in the leaves of S. aqueum and also its potential use as an effective antioxi...

V. K. Priyanka * and R. Rajalakshmi

Department of Botany, University of Kerala, Kariavattom, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6350-57

6350-6357

622

256

51.

PROTECTIVE EFFECT OF NIGELLA SATIVA L. SEEDS EXTRACT ON REPRODUCTIVE TOXICITY INDUCED BY FLUORIDE, ALUMINIUM AND THEIR COMBINATION IN SWISS ALBINO MALE MICE

The aim of the present study was to investigate the possible role of Nigella sativa L. seeds extract on fluoride, aluminum and their combination induced reproductive toxicity in Swiss albino male mice. Nigella sativa L. known as black seeds is used as a form of traditional medicinal plant. Fluoride and aluminum are omnipresent metals and are tremendously used in industries, pharmaceuticals, and fo...

T. Patel and L. Shahani *

Department of Zoology, IIS (Deemed to be University), Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6358-70

6358-6370

408

196

52.

COMPARATIVE SCREENING AND CHARACTERIZATION OF ANTIOSTEOPOROTIC ACTIVITY OF SESBANIA GRANDIFLORA (L) POIR CRUDE LEAF EXTRACT AND ITS NANOPARTICLE FORMULATION ON SAOS-2 CELL LINES

Increasing severity of the disease osteoporosis in postmenopausal women with long term exposure to pharmacotherapy has spurred interest in the development of using food as medicine and phyto-pharmacotherapy. We examined the effect of n-hexane crude leaves extract and its nanoparticle formulation of Sesbania grandiflora in cell proliferation and bone mineralization at different concentrations in Sa...

G. Rachel and A. S. Priscilla *

PG & Research Department of Zoology, Lady Doak College, Affiliated to Madurai Kamaraj University, Tallakulam, Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6371-81

6371-6381

295

171

53.

HYPOGLYCEMIC ACTIVITY PROFILE OF POLYHERBAL FORMULATION (PF) AND POTENTIATION OF HYPOGLYCEMIC EFFECT OF METFORMIN IN RODENTS

Polyherbal formulation (HF) containing different herbs have been used to treat diabetic patients by ayurvedic practitioners in India. The present study reports the effect of HF alone and with metformin on different rat models of hyperglycemia. HF treatment with HF alone and in combination with metformin elicited a significant hypoglycemic effect on epinephrine hyperglycemia and alloxan diabetic ra...

N. S. Vyawahare and V. B. Gawali *

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6382-90

6382-6390

412

185

54.

EFFECT OF TEMPERATURES ON STRUCTURAL, MORPHOLOGICAL AND BIO-PROPERTIES OF ZINC FERRITE NANOPARTICLES

Zinc Ferrite nanoparticles were prepared by chemical co-precipitation method, using PEG as the capping agent. The synthesized materials were annealed at different temperatures such as 400, 500, 600, 700 and 800 °C and the structural characterization studies were conducted by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), UV-Visible Spectro-scopy and Field Emission Scanni...

B. Jyothish and J. Jacob *

Department of Physics, University of Kerala, Mar Ivanios College, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6391-01

6391-6401

538

198

55.

FORMULATION AND EVALUATION OF LANSOPRAZOLE AND DOMPERIDONE MOUTH DISSOLVING TABLETS

Lansoprazole and Domperidone, used as Proton pump inhibitor and antiemetic agents, especially for disease related to gastric ulcer. The purpose of the research was to improve aqueous solubility of drugs by β-CD using a different method, and perform phase solubility study of both drugs using β-CD and calculate Ks, and ∆Gt. Prepare Complex of LAN and DOM with β-CD using different methods like p...

S. G. Rathi *, D. J. Patel, S. K. Shah and B. Y. Joshi

Department of Pharmaceutics, Saraswati Institute of Pharmaceutical Sciences, Dhanap, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6402-12

6402-6412

469

224

56.

ISOLATION AND CHARACTERISATION OF ENDOPHYTES FROM MYRISTICA MALABARICA LAM. AND THEIR BIOASSAY

The present investigation was carried out to isolate, characterize, and to study the antagonistic properties of the endophytic microbes from leaves, bark, flower, and fruits of Myristica malabarica. Standard protocols were followed for the isolation and characterization of bacterial and fungal endophytes. Altogether 16 endophytic fungal isolates and three bacterial isolates were isolated from 51 d...

D. Kanimilli and P. R. Bhat *

PG Department of Biotechnology, Alva’s College, Moodbidri, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6413-24

6413-6424

564

204

57.

SUSTAINED RELEASE OPHTHALMIC IN-SITU GELS OF DORZOLAMIDE HCl FOR GLAUCOMA-AN APPROACH TO FORMULATION AND IN-VITRO EVALUATION

The objective of the present investigation was to formulate the thermosensitive ophthalmic in-situ gels of Dorzolamide HCl for the treatment of glaucoma. Dorzolamide HCl is presently available as conventional eye drops, which has demerits like pre-corneal elimination, lachrymal drainage and no sustained effect leading to poor bioavailability and hence there was a need to develop a better, stable a...

D. S. Sandeep *, R. N. Charyulu and A. Dubey

Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte, Mangaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6425-33

6425-6433

394

182

58.

FORMULATION DESIGN OF EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE EXTENDED RELEASE TABLETS: OPTIMIZATION OF FORMULATION USING STATISTICAL EXPERIMENTAL DESIGN

The objective of the present study was to develop Empagliflozin and Metformin hydrochloride extended release tablets, comprising immediate release empagliflozin and extended release metformin hydrochloride in a single tablet. Wet granulation process was employed to develop extended release part metformin hydrochloride. Impact of various formulation variables in extended release part was assessed u...

R. Chinta * and R. Pilli

Department of Pharmaceutics, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6434-47

6434-6447

715

256

59.

ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PATHOGENIC BACTERIA CAUSING URINARY TRACT INFECTION IN TERTIARY CARE HOSPITAL IN KATHMANDU, NEPAL

Urinary tract infection (UTI) is one of the common clinical conditions in patients presenting to the tertiary care hospital. In general, most of the case of UTI was being treated by empirical antimicrobial therapy before the laboratory results of urine culture; since the antimicrobial susceptibility test of uropathogenic bacteria and antibiotic resistance for enhanced management of UTI with a comm...

B. Pandey, M. Pandit *, S. Jaiswal, A. K. Sah, R. S. Chand and R. Shrestha

Department of Pharmacology, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Nepal.

DOI: 10.13040/IJPSR.0975-8232.11(12).6448-55

6448-6455

759

209

60.

GREEN SYNTHESIS OF SILVER NANOPARTICLES USING ROOT EXTRACT OF AERVA TOMENTOSA FORSK. AND ANALYSE ANTIBACTERIAL AND ANTIOXIDANT PROPERTY

During the present investigations attempt was made to the green synthesis of silver nanoparticles using root extract of Aerva tomentosa Forsk. and to analyze its antibacterial and antioxidant activities. Exposure of the root extract of Aerva tomentosa to aqueous AgNO3 resulted in the formation of silver nanoparticles. The synthesis of silver nanoparticles was confirmed by UV-Vis spectrophotometer ...

S. Singh *, A. Kotiya, P. Lodha and M. Hassan

School of Basic and Applied Sciences, Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6456-62

6456-6462

583

181

61.

PHYTOCHEMICAL SCREENING, IN-VITRO EVALUATION OF ANTIOXIDANT AND ANTIBACTERIAL EFFICACY OF METHANOLIC LEAF EXTRACT OF CLINOPODIUM NEPETA (L.) KUNTZE

The objective of the present study is to evaluate the phytochemical constituents, antioxidant and antibacterial activities of methanolic leaf extract of Clinopodium nepeta (L.) Kuntze. Total phenolic content of leaf extracts was assessed using Folin-Ciocalteu and AlCl3 reagent. Antioxidant assays were evaluated using DPPH, ABTS radical scavenging, and ferric, reducing antioxidant power (FRAP) meth...

M. D. Ghosh *, D. B. Golageri, W. K. S. Sandaruwan, J. Vishnu and S. Rachel

Department of Chemistry, Indian Academy Degree College Autonomous, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6463-69

6463-6469

464

189

62.

BIOACTIVE COMPOUNDS PROFILING AND STRUCTURE ELUCIDATION OF MARTYNIA ANNUA L. HERB

The medicinal herbs used by native people of Mexico since ancient times for numerous therapeutic purposes. The plant is inborn to Mexico but is now well familiarized throughout India on wastelands. In India Martynia annua L. is a well recognized small herbaceous annual plant. The present study was carried out with HPTLC, and the results showed that there were many photochemical in Martynia annua L...

V. Katare * and C. K. Tyagi

Faculty of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Sehore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6470-74

6470-6474

357

225

63.

DEVELOPMENT OF OSMOTIC CONTROLLED RELEASE FORMULATION OF AN ANTIDIABETIC DRUG METFORMIN HYDROCHLORIDE

Osmotic tablets have emerged as a new technology for the delivery of drugs whose release rate is to be controlled. These tablets offer controlled drug release with the help of certain osmogens and also provide zero-order rate kinetics. In the present study, we have developed an osmotic tablet of Metformin Hydrochloride (HCL) to enhance its oral bioavailability. Metformin HCL is a biguanide derivat...

S. Gupta *, N. Choubey, V. K. Dixit and S. Alok

College of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Sehore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6475-80

6475-6480

549

203

64.

IN-VIVO ANTICONVULSANT ACTIVITY OF 2-SEMICARBAZONO-1-HYDROXY, 1-[2-CHLOROPHENYL] -2-[4′-METHOXYPHENYL] ETHANE

A benzoin derivative of 2-Semicarbazono-1-hydroxy, 1-[2-chlorophenyl]-2-[4'-methoxyphenyl] ethane (2C4MBS) was synthesized by benzoin condensation followed by addition reaction. The structure elucidation done using single XRD studies. Maximal electroshock seizure (MES) model was used in the present study to evaluate the anticonvulsant activity of the test drugs. MES seizures were induced by an ele...

B. Thanuja * and C. Kanagam

Department of Chemistry, Sri Sairam Engineering College, Tambaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6481-87

6481-6487

287

164

65.

THE THEORETICAL STUDIES OF MOLECULAR ORBITALS AND THERMODYNAMIC PROPERTIES OF ANTIFUNGAL DRUG

In this work, the molecular structure optimization, electronic properties like local chemical reactivity descriptors (Fukui function analysis for reactive site prediction), and thermodynamic properties (Heat capacity, entropy, zero points vibrational energy, thermal energy, translational, rotational and vibrational energy) of antifungal drugs were theoretically computed. In this work also, electro...

M. Verma, A. Pandey, Ritu, M. K. Verma and J. Sarkar *

Department of Chemistry, University of Lucknow, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6488-93

6488-6493

281

162

66.

EVALUATION OF IN-VITRO ANTIOXIDANT AND NEPHROPROTECTIVE POTENTIALS OF CRINUM ASIATICUM BULBS AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN ALBINO RATS

Objective: To study the in-vitro antioxidant as well as nephroprotective potentials of Crinum asiaticum bulbs’ethanolic extract in contrast to gentamicin-induced nephrotoxicity in albino rats. Materials and Methods: The ethanolic extract of Crinum asiaticum bulbs subjected to preliminary phytochemical analysis to determine the phytoconstituents and evaluation of antioxidant activity was done usi...

S. Suman * and S. V. S. Kumar

Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6494-02

6494-6502

320

182

67.

RECENT ADVANCES TOWARDS THE DEVELOPMENT AND APPLICATIONS OF NOVEL THERAPEUTICS AGAINST CHIKUNGUNYA VIRUS INFECTIONS

Chikungunya infection, caused by the flavivirus Chikungunya, spreads from one person to another by two species of Aedes mosquitoes, i.e., Aedes albopictus and A. aegypti. There is a rapid global emergence and resurgence of Chikungunya infections in India and the Indian Ocean Islands, making it a public health emergency around the globe. There are numerous strategies being adopted by this arbo...

S. Roy *, A. Bhattacharjee, L. Roy and S. Das

Department of Biotechnology, St. Xavier’s College (Autonomous), Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6503-13

6503-6513

335

166

68.

AN AESTHETIC RECONSTRUCTION OF GROSSLY DECAYED PRIMARY ANTERIOR TEETH – A CASE REPORT

Background: Early childhood caries is a rapidly progressing type of dental caries in children. It can lead to partial or complete loss of crown structure. Grossly decayed anterior teeth often lead to discomfort, and the child may face psychological, aesthetic, functional, and phonetic problems that affect the quality of life of the child, and it poses a challenge for the dentist to preserve the te...

D. Subramanyam

Department of Paediatric and Preventive Dentistry, Asan Memorial Dental College and Hospital, Kodungaiyur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6514-17

6514-6517

406

172

69.

DESIGN AND OPTIMIZATION OF OLANZAPINE IMMEDIATE RELEASE TABLETS USING NATURAL SUPER DISINTEGRANTS BY RESPONSE SURFACE METHODOLOGY

Purpose: To formulate and evaluate Olanzapine immediate-release tablets using direct compression. Immediate release of drug from the dosage form is required for rapid onset of action and produce an immediate therapeutic effect. Method: Tablets were formulated using two different natural super disintegrants like Fenugreek and Isabghul and in combination by using Response Surface Methodology. The se...

Y. D. Reddy *, K. Shravani, D. M. Reddy and M. Chetty

Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6518-25

6518-6525

334

168

70.

MOLECULAR DOCKING STUDY OF IBUPROFEN DERIVATIVES AS SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2

The inhibition of the protein cyclooxygenase (COX) is a well-known mechanism for achieving analgesia. Selective inhibitors of cyclooxygenase-2 (COX-2) provide excellent analgesia but can have side-effects. In this study, we chose ibuprofen, a non-selective COX inhibitor that has been safely used for a long time, to develop a novel, selective COX-2 inhibitor. The 3-dimensional structure of the drug...

A. Chebrolu * and S. Madhavan

Independence High School, 10555 Independence Pkwy, Frisco, TX 75035, USA.

DOI: 10.13040/IJPSR.0975-8232.11(12).6526-31

6526-6531

566

264

71.

THE ROLE OF β-ENDORPHIN AND C-PEPTIDE IN STREPTOZOTOCIN INDUCED DIABETIC RATS WITH EFFECT OF ACU-TENS AT ZUSANLI (ST36) ACUPOINTS

Streptozotocin is 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose drug is commonly used to induce diabetes in experimental rats. This study was designed to evaluate the role of β-endorphin and C-peptide in Acu-TENS therapy at Zusanli (ST36) acupoint. Diabetic was induced by Streptozotocin (45mg/kg/body weight) with a single dose of intraperitoneal injection in male albino Wistar rats. The di...

R. Subbulakshmi * and G. Sivakumar

Department of Anatomy, Vivekanandha Dental College for Women, Tiruchengode, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6532-38

6532-6538

620

161

72.

FABRICATION AND CHARACTERIZATION OF METFORMIN HYDROCHLORIDE LOADED MICROSPHERES BY INCORPORATING NATURAL AND SYNTHETIC POLYMERS FOR COMPARATIVE ANALYSIS

The present developed method was designed to fabricate an innovative, simple, cost-effective, and compatible method for controlled delivery of Metformin hydrochloride (MF) by the use of natural and synthetic polymers for comparative analysis. For the most commonly used anti-diabetic drug Metformin hydrochloride, we have tried to formulate microspheres by incorporating natural and synthetic polymer...

M. A. Quazi, N. Khanam * and R. M. Tigote

Faculty of Science and Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6539-49

6539-6549

264

175

73.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF RUTHENIUM (II) COMPLEXES OF SUBSTITUTED 2-{4, 5-BIS[(E)-2-PHENYLETHENYL]-1H-IMIDAZOL-2-YL}-1H-BENZIMIDAZOLE

Ruthenium(II) complexes of the type [Ru(bpy) 2(L)](PF6)2, where L= 2-{4,5-bis[(E)-2-phenylethenyl]-1H-imidazol-2-yl}-1H-benzimidazole (1), 2-{4,5-bis[(E)-2-(4-chlorophenyl)ethenyl]-1H-imidazol-2-yl}-1H-benzimi-dazole (2), 2-{4,5-bis [(E)-2-(4-fluorophenyl) ethenyl]-1H-imidazol-2-yl} -1H-benzimidazole (3), 2-{4 ,5-bis[(E)-2- (4-methylphenyl) ethenyl] -1H-imidazol-2-yl }-1H-benzimidazole (4), 2-{4, ...

M. Kiruthika *, R. Elayaperumal and C. Hariharan

Department of Chemistry, Arignar Anna Government Arts College, Musiri, Trichy, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6550-60

6550-6560

212

114