Volume 4 (2013) - Issue 8, August
Review Articles
ERYTHROCYTES AS A POTENTIAL CARRIER FOR CHRONIC SYSTEMIC DISEASES
Chronic systemic diseases are diseases which require long term drug therapy. Parenteral controlled drug delivery system is often used to treat these diseases. Vesicular bodies like liposome are commonly used as Parenteral controlled depot formulation. It possess disadvantage that they are rapidly removed from body by phagocytosis because they are considered as hapten. So formulating a slow relea...
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PHARMACOGENOMICS: A STEP TOWARDS PERSONALIZED MEDICINE- A SHORT REVIEW
Pharmacogenetics (PGt) is an established discipline that studies the genetic basis of inter-individual variability in the response to drug therapy and pharmacogenomics (PGx) is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. The goal of p...
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PHYTOTHERAPY IN THE TREATMENT OF ARTHRITIS: A REVIEW
As the conventional treatment is associated with large number of side effects, herbal treatment is gaining popularity particularly in the treatment of chronic disease like jaundice, vitiligo, rheumatoid arthritis, asthma etc. Herbal treatment has been identified as safe and effective in treating such disease. The aim of this study was to review systematically the evidences and effectiveness of her...
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SYNTHESIS AND BIOLOGICAL SIGNIFICANCES OF 1, 2, 4-TRIAZOLE AND ITS DERIVATIVES: A REVIEW
In the last few decades, to synthesize the different new heterocyclic compounds along their derivatives which were evaluated for their biological activities as antimicrobial, antiviral, antitumor, anticonvulsant, antifungal, the triazole moiety seems to be very small but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential aga...
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RESEALED ERYTHROCYTES AS A NOVEL CARRIER FOR DRUG DELIVERY: A REVIEW
Drug delivery systems including chemical, physical and biological agents that can enhance the bioavailability, improve pharmacokinetics and reduce toxicities of the drugs. Carrier erythrocytes are one of the most promising biological drug delivery systems investigated in recent decades. Resealed Erythrocytes are biocompatible, biodegradable, possess long circulation half-life and can be loaded wit...
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FLOATING DRUG DELIVERY SYSTEM: A REVIEW
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention. Drug delivery systems are those that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailability ...
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A REVIEW ON BACTERIAL BIOFILM FORMATION AND DISASSEMBLY
The icaADBC gene was first identified in Staphylococcus epidermidis, and is also present in Staphylococcus aureus and other Staphylococcal species. PIA is produced by the gene products encoded by the icaADBC operon. Asymptomatically colonized patients and health care workers are the major sources of MRSA in the hospital environment. MRSA-infected patients in burns units are particularly problemati...
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AN ECONOMICAL BIODEGRADABLE POLYMER FOR NOVEL DRUG DELIVERY APPROACHES: GELATIN
With the advent of newer technologies, in expert opinions, nanobiotechnology is expected to revolutionize or at least significantly improve the pharmaceutical and life science market within the next 15 years. The problem associated with reproducibility prevailed, a need for an economical polymer is experienced by all the researchers so as to repeat and check the reproducibility of systems. To meet...
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Research Articles
EXOGENOUS HYDROGEN SULFIDE ATTENUATES OXIDATIVE STRESS IN SPONTANEOUSLY HYPERTENSIVE RATS
Vascular oxidative stress occurs in hypertensive states and the potential role of antihypertensive drugs as antioxidants is currently under review. Hydrogen sulfide (H2S) is a recently recognized member of gasotransmitters, which may act to decrease blood pressure in experimental hypertension. The present study evaluated the antioxidant potential of hydrogen sulfide in SHR. NaHS, donor of H2S, was...
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QUANTITATIVE DETERMINATION OF ETODOLAC BY UV SPECTROPHTOMETRIC METHOD IN BULK DRUG AND COMMERCIAL FORMULATIONS
The rapid and sensitive UV spectrophotometric method was described for the determination of etodolac, non-steroidal anti-inflammatory drugs. The type of solvent, the range of wavelength and the range of concentration were chosen in order to optimize the conditions. The developed and validated method was successfully applied to the analysis of etodolac without derivatization with any compound in co...
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EVALUATION OF RAMIPRIL ON BLOOD SUGAR LEVEL AND INTERACTION WITH THE ORAL ANTI-DIABETIC DRUGS IN ALLOXAN-INDUCED DIABETIC RATS
Aim: The present study investigates the effect of Ramipril on blood sugar level and interaction with the oral anti-diabetic drugs in alloxan induced diabetic rats. Method: Rats were divided into 10 groups (n = 6) where Group I –II were normal and Group III –X were diabetic. Ramipril at the dose of 0.9 mg/kg body weight were administered to the normal and diabetic rats. In diabetic groups, t...
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IDENTIFICATION OF POTENT VIRTUAL LEADS AS TOPOISOMERASE-II INHIBITORS USING PHARMACOPHORE MODELLING, MOLECULAR DOCKING AND ADME STUDIES
Topoisomerase enzymes are highly expressed in cells which undergo rapid multiplication. Inhibition of this enzyme represents a potential therapeutic approach for diseases such as cancer. In order to understand the structure activity correlation of 2, 4, 6 pyridine based topoisomerase inhibitor, we have carried out a combined pharmacophore modelling, 3D-QSAR studies, molecular docking and virtual s...
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FORMULATION AND CHARACTERIZATION OF CONTROLLED POROSITY OSMOTIC TABLETS OF ACYCLOVIR FOR TREATMENT OF HERPES SIMPLEX
The main objective of present work was to formulate and evaluate swellable controlled porosity osmotic tablets of Acyclovir for the treatment of herpes simplex. This formulation aims to release the drug in zero order pattern, increase bioavailability, reduce frequency of drug dosing and hence increased patient compliance. Acyclovir is a synthetic purine nucleoside analogue that is specially activa...
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STUDYING OMEGA-3 AND OMEGA-6 CONTENT OF NATIVE WALNUT AND STORAGE EFFECT ON IT
Walnuts from Northwest region of Syria was collected to determine Omega-6 (linoleic acid (LA, 18:2n-6)) and Omega-3 (α-linolenic acid (ALA, 18:3n-3)) in their oils, also called essential fatty acids (EFAs). This work was carried out using two different portions of samples. First samples were collected at harvest and second samples stored for one year under normal conditions. The extraction of...
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ANTIBIOTIC PRODUCTION BY MICROBES ISOLATED FROM SOIL
Antibiotic is one of the most important commercially exploited secondary metabolites produced by bacteria, fungi and Streptomyces and employed in a wide range. Most of the antibiotics used today are from the microbes. Bacteria are easy to isolate, culture, maintain and to improve their strain. Bacillus species being the predominant soil bacteria because of their resistant endospore formation and p...
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ANTIBACTERIAL ACTIVITIES AGAINST PYOGENIC PATHOGENS
Pyogenic infection refers to bacterial infection that leads to the production of pus. Antibiotics to treat these pyogenic bacterial infections are routinely prescribed, toxicity of which is serious threat and makes chemotherapy more difficult. Management of pyogenic infections consists of aspiration or surgical drainage followed by appropriate antibiotics. A total of 50 samples were examined, 36...
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OPTIMIZATION OF SOME CULTURE CONDITIONS FOR IMPROVED BIOMASS AND ANTIBIOTIC PRODUCTION BY STREPTOMYCES SPECTABILIS ISOLATED FROM SOIL
A Streptomyces strain was isolated from soil and was identified as Streptomyces spectabilis on the basis of 16 S rRNA gene sequencing. On screening for its ability to produce antimicrobial compounds, it was found to be active only against Gram positive bacteria. Attempts were made to optimize the culture conditions for the production of antimicrobial compounds. Basal medium supplemented with gluco...
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SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND NAPROXEN IN BULK AS WELL AS IN PHARMACEUTICAL FORMULATIONS BY USING RP-HPLC
Esomeprazole is used to treat gastro esophageal reflux disease. Naproxen is a Non-steroidal anti-inflammatory drug (NSAID) used in the treatment of pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. A simple, precise, cost effective RP-HPLC method was developed and validated for the determination of both Esomepraz...
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EFFECT OF NICORANDIL ON BLOOD GLUCOSE LEVEL IN NORMAL RATS
Nicorandil is occasionally given for cardiovascular disorders in patients also suffering from diabetes mellitus. Simultaneous use of nicorandil and sulfonylureas may interfere with the euglycemia. The study was done to find the effect of nicorandil on glucose tolerance in normal male Wistar albino rats, under oral glucose load, adrenaline injection and in receiving oral hypoglycemic drugs. Male al...
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CRUDE ROOT EXTRACT OF ASPARAGUS RACEMOSUS AMELIORATES ACETAMINOPHEN INDUCED UREMIC RATS.
Now days, herbal medicines are widely used to treat, manage and cure the kidney diseases as well as reduce uremia, acute nephritis & nephritic syndrome. The present study was to evaluate the antiuremic and antioxidative effect of Asparagus racemosus (AR) on acetaminophen induced uremic male rats. The study was designed with 36 male albino rats which were randomly divided into 6 groups. Group I...
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ARTOCARPUS ALTILIS – MODE OF ANTI-HYPERGLYCEMIC ACTIVITY: ELUCIDATION BY SUITABLE IN-VITRO AND EX-VIVO TECHNIQUES
Medicinal plants have been reported to play an important role in modulating glycemic responses. Several mechanisms have been proposed for the anti-diabetic effect of medicinal plants such as inhibition of carbohydrate metabolizing enzymes, manipulation of glucose transporters, β- cell regeneration and enhancing insulin releasing activity. In the present study, the hypoglycemic potential of Artoca...
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EXTRACTION EFFICACY, ANTIBACTERIAL POTENTIAL AND VALIDATION OF RP-HPLC COUPLED WITH DIODE ARRAY DETECTION IN HOLARRHENA PUBESCENS
A rapid, simple, sensitive and reproducible RP-HPLC method was developed for the determination of conessine (bioactive steroidal alkaloid) in Holarrhena pubescens, a highly valued medicinal plant extensively used in pharmaceuticals. Separation was achieved on Discovery (R) RP Amide C16 Supelco column (250 µm x 4.6 µm ID) using a mobile phase of acetonitrile: water (95:5 v/v) with flow rate 0.6...
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SIMULTANEOUS QUANTITATION AND VALIDATION OF PHENYLEPHRINE HYDRO-CHLORIDE, AMBROXOL HYDROCHLORIDE AND LEVOCITRIZINE HYDROCHLORIDE IN SYRUP FORMULATION BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
A simple, precise and accurate RP-HPLC method was developed and validated for the estimation of Phenylephrine hydrochloride, Ambroxol hydrochloride and Levocetirizine hydrochloride in syrup formulation. This method is based on HPLC separation of the three drugs on Octadecyl Silane C18 column (250 mm × 4.6 mm, 5.0μ), with isocratic conditions and mobile phase containing 0.01M Sodium dihydrogen ph...
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FORMULATION AND EVALUATION OF EUDRAGIT RS 100 LOADED MICROSPONGES OF FLUTRIMAZOLE
Flutrimazole is a wide spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Conventional topical products typically provide active ingredients in relatively high concentrations but with a short duration of action. Microsponge Systems are designed to allow a sustained rate of release of the active ingredients, offering a potential reduction in side effe...
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SERUM ELECTROLYTES CHANGES WITH ATHEROGENIC INDEX OF PLASMA IN HYPOTHYROID DIABETIC (TYPE-2) YOUNG MALES
Background: Atherogenic index of plasma, a newly emerging lipid parameter, has been employed only in a few studies of diabetics and not at all in hypothyroid type -2 diabetic young males with electrolytes imbalance. Methods: Association between diabetic hypothyroid and electrolytes with atherogenic index of plasma in 50 subjects and aged (25-45 years) matched healthy controlled were studied ret...
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PHYTOCHEMICAL ANALYSIS OF TINOSPORA CORDIFOLIA (WILLD.) MIERS EX HOOK. F. & THOMS STEM OF VARIED THICKNESS
Tinospora cordifolia (Giloe/Guduchi) belonging to the family menispermaceae, is a large extensively spreading glabrous, perennial deciduous twiner with succulent stems and papery bark. It is widely used in Ayurvedic system of medicine “Rasayanas” to the immune system and the body resistance against infections. In modern medicine, T. cordifolia is used for the treatment of general weakness, fev...
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QSAR STUDIES ON NOVEL 1, 4-DIHYDROPYRIDINE DERIVATIVES
QSAR studies on N3, N5-diphenyl-1, 4-dihydropyridine-3, 5-dicarbohydrazides [2A-2D’] and 2, 6-dimethyl-1,4-dihydro-pyridine-3, 5-yl-bis[carbonyl-2-(phenyl)]pyrazolidine-3, 5-diones] [3A -3D’] were carried out. 3D chemical structures were given as input and desired molecular attributes and molecular indices were selected. Various molecular descriptors were studied using TSAR (Tools for Structur...
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FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF METFORMIN HCl FOR THE TREATMENT OF TYPE-2 DIABETES MELLITUS
Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. Ind...
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QUANTITATIVE ESTIMATION OF LEVOFLOXACIN AND ORNIDAZOLE BY UV SPECTROPHOTOMETER: A MIXED HYDROTROPY SOLUBILIZATION APPROCH
Two simple, accurate, novel, safe and precise methods developed for the simultaneous estimation of poorly water-soluble drugs Levofloxacin and Ornidazole in tablet dosage form using 2M sodium acetate and 8M urea solution (50:50% W/W) as mixed hydrotropic solution. Sodium acetate and urea solution did not show any absorbance above 240 nm and thus no interference in the estimation of drugs were seen...
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PROTECTION OF BIOMOLECULES AGAINST IN VITRO OXIDATIVE DAMAGE BY THE ANTIOXIDANTS FROM METHANOLIC EXTRACT OF TRIGONELLA FOENUM- GRAECUM SEEDS
Fenugreek (Trigonella foenum-graecum) seeds were extracted in 80% methanol to examine the content of various potent antioxidant compounds and their influence on in-vitro oxidation of biomolecules i.e. amount. proteins, lipids and DNA. Fenugreek extract had polyphenols (9.47±0.10 mg GAE/g dry seeds) as major antioxidant principle. Gallic acid (170.335µg), caffeic acid (164.550 µg), ellagic acid ...
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ANTIOXIDANT AND ANTICANCER ACTIVITIES OF ETHANOLIC EXTRACT OF FICUS GLOMERATA ROXB. IN DMBA INDUCED RATS
The present study was designed to evaluate the antioxidant and anticancer activities of the ethanolic leaf extract of Ficus glomerata Roxb. on the basis of enzymatic and non-enzymatic antioxidants, xenobiotic enzymes and histopathological parameters in 7, 12- dimethylbenz(a)anthracene (DMBA) induced mammary carcinoma in rats. F. glomerata is large evergreen tree, found all over India and South Eas...
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PRODUCTION OF ANTIBIOTIC FROM ACTINOMYCETES ISOLATED FROM NAGPUR REGION AND OPTIMIZATION OF PARAMETERS TO INCREASE THE YIELD
Actinomycetes species Streptomyces violaceorubidus, strain RC 1796 was isolated from Nagpur region which was identified from MTCC Chandigarh. The inoculum was prepared for fermentation using Streptomyces violaceorubidus RC 1796.Different fermentation parameters were studied to increase the yield which includes types of fermentation media, temperature, pH, agitation condition, time period of fermen...
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TO ACCESS THE ROLE OF MUSIC THERAPY IN DEPRESSION AND THEIR COMPARISON WITH DRUG THERAPY
Depression can be termed as a state of mind where in the person has negative thoughts, pessimistic views of future and constantly in sad mood, he feels lonely to the extent that he may committing suicide. A decrease in serotonin and nor epinephrine level can cause depression and Dopamine plays an important role in regulating our drive to seek rewards and obtain a sense of pleasure. Music therapy i...
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DEVELOPMENT OF MICROEMULSION FOR SOLUBILITY ENHANCEMENT OF ATORVASTATIN CALCIUM
Atorvastatin Calcium, competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway, thereby lowering cholesterol level in plasma of body. Oral bioavailability of Atorvastatin Calcium is very low (less than 4%), due to its poor water solubility. The aim of this investigation was to develop a microem...
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SYSTEMATIC FORMULATION DEVELOPMENT OF IMMEDIATE RELEASE TABLET DOSAGE FORM USING QUALITY BY DESIGN APPROACH
The main goal of this study was to develop a stable formulation of model antibacterial drug as an immediate- release tablet systematically using Quality by Design approach of which design of experiments is an integral part. The model drug was found to be a BCS class II drug official in USP having a plasma half-life of three to four hours. The formulation development work was initiated with wet gra...
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FORMULATION AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF OLMESARTAN MEDOXOMIL
Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker used for the treatment of hypertension. In this work an attempt was made to mask the metallic taste and enhance the solubility and dissolution rate of poorly soluble OLM by formulating it as inclusion complexes with β-cyclodextrins (β-CDs) as complexing agent in 1:1 molar ratio. The drug – CDs complexes were prepared by physical ...
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A STUDY OF PHARMACEUTICAL CARE IMPACT ON CARDIOVASCULAR RISK IN DIABETIC AND HYPERTENSIVE PATIENTS
Background: Coronary heart disease is the most common type of heart disease and is the major cause of death in India and a major cause of death worldwide 1. It was thought previously to affect initially the higher income countries, but now CHD leads to more death in low- and middle-income countries such as India. Lifestyle modification is the main stay of treatment in preventing coronary heart dis...
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LEAD FINDING FROM WHOLE PLANT OF CURCUMA LONGA WITH OXIDATIVE POTENTIAL
The present study deals with the antioxidant activity, drug likeness score and bioactivity score of the compounds isolated from Curcuma longa and search lead antioxidant compound through molinspiration software. We have taken ten compounds from this plant. All the compounds were further subjected to molecular properties prediction and drug likeness by Molinspirstion and found in compliance with ...
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COMPARATIVE EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF ETHANOL EXTRACT OF TAXUS BACCATA, PHYLLANTHUS DEBILIS, PLECTRANTHUS AMBOINICUS AGAINST MULTI DRUG RESISTANT BACTERIA
Ethanol extract of the leaves of Taxus baccata, Phyllanthus debilis, Plectranthus amboinicus were studied for their antimicrobial property against multidrug resistant bacterial strains (MDR) from clinical specimens. Of these three plants, the most potent antimicrobial plant was Phyllanthus debilis followed by Taxus baccata (MIC range 80 - 400μg/ml) having broad spectrum activity, whereas Plectran...
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A STUDY COMPARING RESCUE MEDICATIONS: ARFORMOTEROL AND SALBUTAMOL NEBULIZATION IN EXACERBATION OF NON-SEVERE ASTHMA AT A TERTIARY CARE CENTER, NOT NEEDING HOSPITALIZATION
Objectives: Arformoterol is the (R, R) - enantiomer of formoterol, a short and long acting β-2 agonist bronchodilator and is distinguishable from the racemic (R, R/S,S) - diasteriomer of formoterol, which is most commonly used. Some in vitro data show significant bronchodilatation, inhibition of inflammation and marked baseline airway reversibility with arformoterol. Yet, there is a dearth of stu...
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INVESTIGATION ON THE IN VITRO ANTIOXIDANT, ANTIMUTAGENIC AND CYTOTOXIC POTENTIAL OF THYMUS VULGARIS L. HYDRO-ALCOHOLIC EXTRACT
Aim: To evaluate the in vitro antioxidant, antimutagenic and cytotoxic property of hydro-alcoholic extract of Thymus vulgaris L. by subjecting it to free radical scavenging, Ames and MTT assay respectively. Methods: Powdered Thyme leaves were extracted in a Soxhlet apparatus using 70% ethanol to obtain a dry extract. The extract was assessed for its total phenolic, tannin, flavonoid and flavono...
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NEW METHOD DEVELOPMENT FOR EXTRACTION AND ISOLATION OF PIPERINE FROM BLACK PEPPER
Piperine, a major alkaloid in black pepper is one of the most promising bioenhancers till date. Other methods used for its extraction suffer drawbacks such as poor extraction efficiency, tedious and expensive isolation methodology, piperine photodegradation, etc. Hence a simple, rapid and efficient method has been developed for the isolation of piperine from the fruits of Piper nigrum. The methods...
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PROCESS OPTIMIZATION: A CRITICAL FACTOR FOR EFFECTIVE DRUG DOSAGE DELIVERY
The critical nature of pharmaceutical dosage forms requires that both formulation and process variables are optimized in order to achieve desired quality outcome. In this study, process optimization is examined with a view to position the final product in such a way as to deliver the expected performance. Six formulations were designed with similar excipients and nifedipine as model drug. Each for...
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DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION FOR PIPERINE AND GALLIC ACID IN ZEAL HERBAL GRANULES BY HPTLC METHODA
A simple HPTLC method has been developed for the estimation of Gallic acid and Piperine in methanolic extract of Zeal herbal granules [ZHG], a Polyherbal formulation. The separation was performed on TLC aluminum plates precoated with silica gel 60 F254, good separation was achieved in the mobile phase of toluene: ethyl acetate: formic acid (11: 15: 1v/v/v) and densitometry determination of Gallic ...
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ANTIMICROBIAL ACTIVITY OF STEM BARK OF COMBRETUM ALBIDUM G. DON; A TRADITIONAL MEDICINAL LIANA
Traditional knowledge and ethno-botanical use of plants have been widely acknowledged all over the world. In the present scenario, emergence of multiple drug resistance to human pathogenic organisms, this has necessitated a search for new antimicrobial substances from other sources including plants. Combretum albidum, a traditional medicinal liana, used by rural peoples, villagers and tribals resi...
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GREEN SYNTHESIS OF PLANT-MEDIATED SILVER NANOPARTICLES USING MANGIFERA INDICA AND SYZYGIUM CUMINI LEAF EXTRACT
Nanoparticles of silver (Ag-NPs) have received tremendous research attention for their widespread applications in recent times. The most significant one is their antibacterial properties for which they have been used from food storage to medical supplies. The present study describes a novel green synthesis of silver nanoparticles by using Mangifera Indica and Syzygium cumini leaf extract. The gre...
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POLLUTION INDUCED CHANGES IN PLANTS LOCATED AT CHINNATIRUPATHI, SALEM, TAMILNADU, INDIA
Air pollution tolerance index was assessed with plant species located at ChinnaTirupathi, Salem, Tamil Nadu, India. This study was conducted during March, 2013. Since, all the lands are converted to buildings, it is essential to know more about plants and its benefits offered to the environment and the dangers, risks caused by cutting trees. In this study, our aim is to evaluate, whether the plant...
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ETHNOBOTANY AND ANTIOXIDANT DETERMINATION OF PHOEBE COOPERIANA FRUIT-A HIGHLY UTILIZED WILD FRUIT IN ARUNACHAL PRADESH, INDIA
The fruit of Phoebe cooperiana U.N Kanjilal ex A. Das is highly priced and one of the most preferred folk food among the Indigenous people of Arunachal Pradesh, India. The methanol extract of fruit collected from East Siang District of Arunachal Pradesh, India were evaluated for total phenolic content, total flavonoid content and antioxidant potential. The methanol extract of fruit were subjected ...
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IN VITRO AND IN VIVO ANTIHEPATOTOXIC ACTIVITY OF OROXYLUM INDICUM AGAINST CARBON-TETRACHLORIDE INDUCED HEPATIC DAMAGE
Evaluation of the anti-hepatotoxic activity of methanol-dichloromethane (MDM) extract of Oroxylum indicum (OI) whole plant on carbon tetrachloride (CCl4)- induced hepatotoxicity in rat liver explant cultures (in-vitro) and chronic liver damage in rats (in-vivo). In toxicant (CCl4) treated explants culture set (in-vitro), the marker enzymes GOT, GPT and ALP level increased significantly (p<0.001...
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A NEW POLARIMETERIC METHOD FOR THE ANALYSIS OF SUCROSE – IN IRON SUCROSE RAW MATERIAL, IRON SUCROSE INJECTION AND INPROCESS BULK FORMULATIONS
A simple, sensitive, rapid, accurate and economical polarimeteric method has been developed and subsequently validated for simultaneous determination of Sucrose - in Iron Sucrose Raw material, Iron Sucrose Injection and Inprocess Bulk sample of Iron Sucrose formulations in pharmaceuticals. The usual measure of purity of sucrose is by polarimetry - the measurement of the rotation of plane-polarized...
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ALTERATIONS IN DEVELOPING RBCs AFTER PRENATAL AND POSTNATAL EXPOSURE TO LEAD ACETATE AND VITAMINS
Purpose: The current investigation was carried out to study the hematopathological changes in the developing red blood cells of neonate of Swiss albino mice exposed with lead acetate and vitamins. Methods: Lead acetate was administered orally at 8, 16, 32 mg /kg/BW to selected pregnant females from 10th day of gestation to 21st day of lactation. Vitamin C (166 mg/kg BW) and vitamin E (133mg/kg ...
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1170
ANTI BACTERIAL ACTIVITY OF THE FLOWERS OF WOODFORDIA FRUTICOSA ON DIFFERENT MICRO-ORGANISM
Use of plants as a source of traditional healing systems around the world that utilize herbal remedies is an important source for the discovery of new antimicrobials against resistant strains of bacteria. It is being used as a source of medicinal agents for antibacterial, antihelminthic, astringent, emetic, sedative and stimulant. A 10 g dried leaves powder of Woodfordia fruticosa was extracted se...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF EZETIMIBE THROUGH LIQUISOLID TECHNIQUE
The present study enlightens to enhance the dissolution profile, absorption efficiency and bioavailability of water insoluble drug like Ezetimibe. It is a poorly soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. There are several techniques to enhance the dissolution of poorly soluble drugs, in which the ...
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DEVELOPMENT OF CHITOSAN CAPSULE FOR COLON SPECIFIC DELIVERY OF BUDESONIDE
The principal derivative of chitin is Chitosan, produced by alkaline deacetylation of chitin, is a non-toxic, biodegradable and biocompatible, cationic polymer. Chitosan has been widely used in the formulation of particulate drug delivery systems to achieve controlled drug delivery. The main objective of the study was to develop enteric coated Chitosan capsule containing budesonide for targeting t...
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ANTIBACTERIAL EVALUATION OF SOME COMMON MEDICINAL PLANTS USED IN ASAVA AND ARISHTA PREPARATION
Various medicinal properties have been attributed to natural herbs. The use of traditional medicine is widespread in India. These herbal remedies are an important source for the discovery of new antimicrobials against the resistant strains of bacteria. Asavas and Arishtas are specially prepared ayurvedic medicines. They are alcoholic solutions containing all the active ingredients of the drugs of ...
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1562
STANDARDIZATION OF SOME HERBAL ANTIDIABETIC DRUGS IN POLYHERBAL FORMULATION & THEIR COMPARATIVE STUDY
Ayurvedic formulations are used to treat a wide variety of diseases including Diabetes Mellitus Standardization of Herbal Formulation is Essential in order to assess the Quality of drugs. The Present Study Reports for Standardization of Eight Herbal Anti-diabetic drugs- Momordica charantia (seeds), Syzigium cumini (seeds), Trigonella foenum (seeds), Azadirachta indica (leaves), Emblica officinalis...
4154
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EVIDENCE BASED HOMOEOPATHY IN TREATING LONG STANDING & RECURRING VENOUS ULCER- A PROSPECTIVE AND INTERVENTIONAL STUDY
The common cause of leg ulceration in Western countries is venous disease of the lower limb.Venous insufficiency causes appreciable disability. Venous ulcer is one of the most prevalent diseases in the western countries and India, which can hamper personal and professional life of individual. After various methods of modern medicinal treatment and management there is a chance recurrence .This ca...
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FORMULATION AND DEVELOPMENT OF LIPOSOMAL DELIVERY OF ANTICELLULITE
Aim: Cellulite treatment incorporates iso-slim complex to reload the skin with minerals and trace elements to achieve absolute effectiveness in treating cellulite condition. The revitalizing effect of anticellulite helps to refine and reshape the silhouette and give the body a more toned, defined and firmer appearance. Aim of present work was to develop and investigat...
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