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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 6 (2015) - Issue 4, April

Review Articles

 
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1.

PHARMACOLOGICAL OVERVIEW OF FREEZE DRIED ANDAMAN NONI (MORINDA CITRIFOLIA.L) AGAINST CANCER AND NEUROLOGICAL DISORDER

Noni (Morinda citrifolia) is one of the important traditional medicinal plants have been used by Polynesia over a period of 2000 years. Morinda citrifolia belongs to family Rubiaceae (Coffee family) which is an evergreen small sized tree, with glossy and deeply veined leaves found in tropical regions and islands of South Pacific, West Indies, India, Africa, and Australia.  Noni fruit juice tradit...

Hariom Singh, Saswata Banerjee, Saumen Karan, Biswajit Das, Debjyoti Naskar and Tapan Kumar Chatterjee*

Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bangal, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1342-50

1342-1350

3979

2760

2.

MULTIUNIT FLOATING DRUG DELIVERY SYSTEM A SIGNIFICANT TOOL FOR THE TREATMENT OF PEPTIC ULCER DISEASE

The gastroretentive drug delivery system has been utilized to obtain prolonged and uniform release of drug in stomach. Thus increase bioavailability and decrease the administration frequency. A peptic ulcer is a break in the lining of the stomach, esophagus or duodenum. Peptic ulcer may be due to H. Pylori bacteria, acid of the stomach cell or nonsteroidal anti-inflammatory drugs (NSAIDS). The gas...

P. Singh , V. K. Chaudhari *, P. K. Verma , A. K. Singh and V. K. Yadav

Department of Pharmacy , Kunwar Haribansh Singh College of Pharmacy, Jaunpur, UP, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1351-62

1351-1362

2647

1033

3.

NANOEMULSIONS: A VERSATILE DRUG DELIVERY TOOL

Since last decade, the interdisciplinary research of Nanoemulsions (NEs) have gained great attention in research and drug designing owing to their promising range of applications in the field of pharmaceutics, drug delivery through different route, cosmetics, to name a few. In addition to the small droplet size these non-equilibrium liquid systems have interesting properties including optical clar...

Jyoti Khanna Bangia * and Hari Om

Deenbandhu Chhotu Ram University of Science and Technology, Murthal, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1363-72

1363-1372

3156

1395

4.

PHARMACOLOGICAL AND PHYTOCHEMICAL REVIEW ON ACTINIOPTERIS RADIATA.

Herbal medicines are precious and valuable gift of nature. Indian system of medicine viz. Ayurveda is much prevailing in our country, which comprises of various traditional medicines. The practice of medicinal herbs for treating the diseases is very well known from ancient time. Actiniopteris australis (Syn: A. radiata; A. Dichotoma), is a xerophytic species of the fern family Actiniopteridaceae ,...

J. B. Naik , D. R. Jadge *, A. N. Deshpande, A. B. Gadgul and A. R. Siddiqui

University Department of Chemical Technology, North Maharashtra University, Jalgaon, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1373-77

1373-77

2961

1236

Research Articles

 
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5.

SUBACUTE ANTIDIABETIC PROPERTIES OF AGERATUM CONYZOIDES LEAVES IN DIABETIC RATS

This study investigated the antidiabetic activity of the aqueous extract of the leaves of Ageratum conyzoides. Streptozotocin induced hyperglycemia male adult albino rats were used to study the antidiabetic effect of Ageratum conyzoides aqueous extract (at doses of 100, 200 and 300 mg/kg respectively). The diabetic rats were housed in metabolic cages, for the whole period of the experiment. Body w...

N. Nyunaï *, EH. Abdennebi , J. Bickii and M. A. Manguelle-Dicoum

Institute of Medical Research and Medicinal Plants Studies, Yaoundé, Cameroon.

DOI: 10.13040/IJPSR.0975-8232.6(4).1378-87

1378-1387

3070

3194

6.

RIVAROXABAN IMPROVES MYOCARDIAL ISCHEMIA REPERFUSION INJURY COMPLICATIONS IN OBESE RATS

Rivaroxaban is a direct inhibitor for Factor Xa that used orally for prevention and treatment of thromboembolic disorders through inhibition of thrombin synthesis. In this study we hypothesis that rivaroxaban pretreatment might play a role in reducing the complications of myocardial ischemic reperfusion injury (IRI) in a rat model of obesity. R- hirudin (a commercially available anticoagulant drug...

H. E. Mohamed *, S. I. Ali, E. A. Ahmed , Md. A. Shaheen and Y. K. Mahmoud

Biochemistry Department , Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(4).1388-95

1388-1395

2752

1051

7.

IDENTIFICATION OF GENES EXPRESSED DURING WATER STRESS IN FOUQUIERIA SPLENDENS SSP. BREVIFLORA

We identified genes in Fouquieria splendens ssp. breviflora (Fouquieriaceae) that were expressed due to water deficits. RNA was extracted from dehydrated stem samples that were collected directly from Camargo, Querétaro following hydration for two weeks. The plants were grown in two states, drought and hydrated. We then performed subtractive hybridization. The obtained sequences were inserted int...

R. I. M. Sánchez, M. D. P. Crisóstomo Vázquez, M. A. V. Alberto, J. L. M. Sánchez and E. J. Cardoso

Laboratory of Parasitology Research, Dr. Márquez #162 Col. Doctores, México

DOI: 10.13040/IJPSR.0975-8232.6(4).1396-00

1396-1400

2577

975

8.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DETERMINATION OF LEVOFLOXACIN IN TABLET USING UV AND FLUORESCENCE DETECTORS SIMELTANIOUSLY

Simple, sensitive, precise, accurate, and specific reversed –phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of levofloxacinin pharmaceutical tablets. Levofloxacin is a third generation fluoroquinolones with a wide spectrum of action against gram-positive and gram-negative bacteria, anaerobic microorganisms and atypical pathogens. I...

H. Mando*and A. Hasan

Faculty of Pharmacy, Damascus University, Damascus

DOI: 10.13040/IJPSR.0975-8232.6(4).1401-06

1401-1406

3620

1029

9.

NUTRIENT CONTENT AND ANTIOXIDANT PROPERTIES OF SOME POPULAR FRUITS IN BANGLADESH

The present study discussed the nutritional content and quantification of eleven bioactive phenolic antioxidant contents in the water, methanol and acetone extracts of four different edible fruits viz. Musa acuminate (banana), Ananascomosus (pineapple), Psidiumguajava (guava) and Malusdomestica (apple) using HPLC-DAD. Nutritional analysis showed that the most moisture and fiber-containing fruit wa...

Md Rakibul Islam, Sanjida Afrin , Tanjir Ahmed Khan and ZakirHossain Howlader*

Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.6(4).1407-14

1407-1414

3251

838

10.

HEPATOPROTECTIVE ACTIVITY OF FICUS DALHOUSIAE MIQ LEAVES ETHANOLIC EXTRACT ON CARBON TETRACHLORIDE AND PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS

Leaves and bark preparations of Ficus dalhousiae Miq (Moraceae) are used in folklore and Siddha system of medicine for liver and skin ailments. So the intent of the present study was to evaluate the Hepatoprotective effect of Ficus dalhousiae Miq leaves ethanolic extract (FDLEE) by means of Carbon tetrachloride and Paracetamol induced hepatotoxicity model in Albino rats. Administration of carbon t...

Md Atif *, S. A. Rahman , S. S. Ghori, Md I. Ahmed, S. B. Mahmood and Md. Abdul Muqtadar

Shadan College of Pharmacy , Peerancheru, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1415-21

1415-1421

1997

603

11.

EVALUATION OF PHYTOCHEMICAL, ANTIOXIDANT, ANTHELMINTIC AND ANTIMICROBIAL PROPERTIES OF CRATAEVA NURVALA BUCH. HAM. LEAVES

The aim of this study was to determine principle phytochemical classes and total phenolic contents and to investigate antioxidant, anthelmintic and antimicrobial activities of ethanolic extract of Crataeva nurvala leaves. Standard test methodology suitable for each chemical class was followed to screen out major chemical classes preliminarily. The total phenolic content of ethanolic leaf extract w...

F. Khatun*, Md. Mahfuz-E-Alam, N. Sultana Tithi, N. Nasrin and Md. Asaduzzaman

School of Chemistry and Molecular Biosciences , The University of Queensland, St Lucia, QLD, Australia

DOI: 10.13040/IJPSR.0975-8232.6(4).1422-29

1422-1429

2985

986

12.

ANTIOXIDANT AND HAEMATOPROTECTIVE ACTIVITY OF THE SARACA INDICA STEM BARK

Present study was designed to evaluate the antioxidant and hematoprotective activity of methanolic extract of saraca indica bark. Antioxidants and hematoprotective effect of saraca indica bark may be due to its polyphenolic compounds. Polyphenols act as reducing agents via scavenging of free radicals and chelation of transition metals. The hematoprotective activity of Saraca indica was studied in ...

C. K. Dubey, A. K. Meena, V. Mishra, P. Singh, F.W. Bansode and R. K. Singh

Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1430-37

1430-37

2895

1001

13.

EVALUATION OF THE IMMUNOMODULATORY ACTIVITY OF THE ROOTS OF ICHNOCARPUS FRUTESCENS

The objective of the present study was to investigate the immunomodulatory activity of the roots of Ichnocarpus frutescents R.Br. In the present study Pet. Ether, Chloroform and Methanolic fractions of the ethanolic extract of the roots of Ichnocarpus frutescens, in the doses of 10mg/kg and 30mg/kg, were administered orally to evaluate the immunomodulatory activity. The Methanolic fraction in the ...

V. R. Patil, V. M. Thakare and V. S. Joshi*

Department of Pharmacognosy, Hon’ble Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Dist- Jalgaon, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1438-44

1438-1444

1775

656

14.

FORMULATION AND EVALUATION OF CHRONOMODULATED COLONIC DRUG DELIVERY OF NIFIDIPINE

The pulsatile drug delivery works upon the system that releases active pharmaceutical ingredient completely and rapidly after a desired lag time. This type of approach was advantageous for: Drugswith extensive first pass metabolism and biological tolerance. Locally absorbed or acting drugs to a specific site in the intestinal tract (e.g. colon). Adaptation of therapy according to chronopharmacolog...

Renu Dinkar, Govind Mohan and Kumud Upadhyaya*

Department of Pharmaceutical Sciences , Kumaun University, Nainital, Uttaarkhand, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1445-51

1445-1451

1761

636

15.

PHYTOCHEMICAL INVESTIGATIONS AND ANATOMICAL STUDY OF TWO SPECIES OF CALOTROPIS FROM CHANDIGARH

Medicinal plants have been used since prehistoric period for the cure of various diseases. Hence the herbal medicines occupy distinct position right from the primitive period to present day. Calotropis procera, a wild growing plant of family Asclepiadaceae, is well known for its medicinal properties. Different parts of this plant have been reported to exhibit anti-inflammatory, analgesic, and anti...

Richa*, Kaur Harsimran and Sharma Shikha

Department of Botany, Panjab University, Chandigarh, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1452-59

1452-1459

2943

1388

16.

SUITABILITY OF DIFFERENT GRADES OF GELUCIRE AND PEG-6000 FOR SOLUBILITY ENHANCEMENT OF TINIDAZOLE BY PROCESS OF SOLID DISPERSION

Tinidazole is a synthetic antiprotozoal and antibacterial agent which is practically insoluble in water.Oral dose of tinidazole is very high (2gm) owing to its limited solubility. Present research focuses on enhancement of solubility of tinidazole using the technique of solid dispersion which is reported to be one of the simple technique for solubility enhancement using various grades of Gelucire ...

Ajay Sahoo and Shilpa Bhilegaonkar *

PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa , India

DOI: 10.13040/IJPSR.0975-8232.6(4).1460-64

1460-1464

3030

1250

17.

AMELIORATIVE EFFECT OF PUNICA GRANATUM L. AGAINST BLEOMYCIN INDUCED PULMONARY FIBROSIS IN RATS

Aim: Bleomycin (BLM), a potent anticancer agent widely used in the treatment of cancer is an antibiotic isolated from Streptomyces verticillus. BLM has been reported to cause pulmonary fibrosis that limits the chemotherapeutic efficiency. The present study aims to evaluate the efficacy of the aqueous extract of pomegranate (Punica granatum) against BLM induced pulmotoxicity in rats.  Methods: The...

Mayilsamy Dharani * and Shwetha Kalava

Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore - 641029, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1465-72

1465-1472

2117

802

18.

ANTI-INFLAMMATORY ACTIVITY OF CROCUS SATIVUS EXTRACT IN EXPERIMENTAL ARTHRITIS

Rheumatoid arthritis is one of the most serious medical problems leading to bone and cartilage destruction. The disease affects approximately 1% of the total world population. Mostly the women are affected. The pathogenesis of the disease is still not clearly understood. Free radicals and inflammatory molecules such as TNF-α, IL-1β etc have been recognized as major players in the progression of ...

Brijesh Rathore *, Kalpana Jaggi , Sumit Kumar Thakur , Abhishek Mathur and Farzana Mahdi

Department of Biochemistry , Era’s Lucknow Medical College & Hospital, Sarfarajganj, Hardoi Road, Lucknow-226 003 (U.P), India

DOI: 10.13040/IJPSR.0975-8232.6(4).1473-78

1473-1478

2710

765

19.

CYTOGENETIC STUDY OF CHROMOSOMAL ABERRATIONS ASSOCIATED WITH ACUTE LEUKEMIA

The most common cause of death is bone marrow failure. Chromosomal analysis is essential for the diagnosis, response to treatment and prognosis of leukemia. Conventional karyotyping which shows the structural, numerical and compound aberrations have improved the genetic diagnosis of leukemia. The bone marrow samples from patients (2-60yrs) of 53 patients (32 male and 21 female) suffering from vari...

D. N. Mishra , S. K. Panda , S. K. Sahoo, J. S. Prusti , T. Patra, P. Panda , P. K. Chinara and S. Rout *

Department of Anatomy , AIIMS, Bhubaneswar, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1479-88

1479-1488

1968

542

20.

NEUROPATHIC PAIN SYMPTOMS OF POST HERPETIC NEURALGIA PATIENTS WITH CYP2D6 POLYMORPHISM UNDERGOING TRAMADOL TREATMENT

Main aim of this study was to find out relation of CYP2D6 polymorphism with tramadol action in post herpetic neuralgia (PHN) patients. This non- responders versus responders study mainly includes 246 patients (age group 20-80 years) of PHN, assigned into two groups depending upon their response to tramadol treatment at the end of 2nd week of drug therapy. On the basis of CYP2D6 polymorphism, an al...

Namita Vilas Nasare *, Basu Dev Banerjee, Pravin Suryakantrao Deshmukh ,, Pramod Kumari Mediratta , Rafat S Ahmed , Ashok Kumar Saxena and Sambit Nath Bhattacharya

Department of Pharmacology , Environmental Biochemistry and Molecular Biology Laboratory, University College of Medical Sciences & G.T.B. Hospital, Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1489-01

1489-01

1780

518

21.

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC LEAVES EXTRACT OF LASIA SPINOSA AND ITS ROLE IN PREVENTION OF HYPERLIPIDEMIA INDUCED PANCREATITIS IN RATS

Leaves, rootstock, fruit and decoction of Lasia spinosa (Araceae) are used in folklore medicine for Gastrointestinal, Respiratory and Skin diseases. The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Lasia spinosa and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The evaluation of the Antihyperlipidemic a...

S. B. Mahmood*, Md. Atif, Syed Rashid Ali, Md. Ibrahim Ahmed and Shaik Abdul Rahman

Shadan College of Pharmacy, Peerancheru, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1502-08

1502-1508

1767

558

22.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR QUANTITATIVE DETERMINATION OF RELATED SUBSTANCES PRESENT IN ELETRIPTAN HYDROBROMIDE DRUG SUBSTANCE

An efficient and sensitive RP-HPLC method was developed and validated for the estimation of related substances in Eletriptan hydrobromide drug substance which were identified and characterized by LCMS, FTIR, 1HNMR, 13CNMR techniques. The method was carried out on a Purosphere STAR RP-8e column at temperature 20°C using a phosphate buffer at pH 4.0 and solvent mixture consists of acetonitrile, wat...

M. V. Dalawai *, S. Nallapati, J. K. Vundavilli, P. K. S.R. Kothapalli , U. K. Ray , P. D. Sanasi, P. Rajput and H. K. Sharma

Aurobindo Pharma Limited Research Centre-II, Indrakaran village, Sangareddy mandal, Medak district, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1509-16

1509-1516

2323

1554

23.

THREE-DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES ON DIVERSE STRUCTURAL CLASSES OF NATURAL FLAVONOIDS AS AMV AND HIV REVERSE TRANSCRIPTASE INHIBITORS USING CoMFA AND CoMSIA

In this study, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on a series of 73 experimentally reported natural flavonoid derivatives as AMV and HIV Reverse transcriptase (RT) inhibitors with pIC50 values ranging from 4.00 to 5.92. Based on alignment, highly predictive CoMFA and CoMSIA were obtained with cross-validated q...

Shravan Kumar Gunda*, Sri Swathi Mutya, Sharada Durgam, Vijaya Lakshmi Lokirevu and Mahmood Shaik

Bioinformatics Division, Osmania University, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1509-36

1517-1527

1708

554

24.

STUDY OF DISSOLUTION CHARACTERISTICS OF IBUPROFEN BY DIFFERENT POLYMERS AND SOLID DISPERSION TECHNIQUES

Poor water solubility is characterized by low dissolution rate and consequently reduced bioavailability. Formulation of solid dispersion has attracted considerable interest where dispersing a poorly water soluble drug in a water soluble polymer matrix improves the dissolution characteristics and bioavailability of the drug. The aim of the present study was to enhance the dissolution rate and bioav...

Farhana Akter , Mukta Saha *, Johura Ansary , Arnab Debnath and Tahiatul Shams

Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(4).1528-37

1528-1537

3683

1107

25.

THERAPEUTIC EFFICACY OF VERNONIA CINEREA IN SELENITE INDUCED CATARACT MODELS

We have evaluated the efficacy of methanolic extract of Vernonia cinerea (MEVC) in selenite induced cataract using Sprague Dawley rats. Previous reports suggest that phytochemicals or natural plant products retard the process of cataractogenesis by scavenging free oxygen radicals. Hence, the present study sought to assess the potential of MEVC on in vivo selenite induced cataract models. The antio...

R. Asha and Annie Abraham*

Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram - 695 581, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1538-46

1538-46

1679

614

26.

EVALUATION OF ANTIMICROBIAL ACTIVITY OF PLANT EXTRACTS

The objective of this study was to evaluate the possible antimicrobial properties of water, methanol, chloroform and Petroleum ether extracts of leaves of different Indian medicinal plants including Mangifera indica Linn, Ixora parviflora Vahl, Psydium guajava Linn, Calotropis procera Ait. The extracts were investigated individually for in vitro antibacterial activity by cup plate (well diffusion)...

Suvarna Vasanti

Department of Pharmaceutical Chemistry, S.V.K.M’S, Dr. Bhanuben Nanavati College of Pharmacy, Mithibhai College Campus, V.M. Road. Vile Parle- (W), Mumbai - 400 056, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1547-52

1547-1552

1983

752

27.

SYNTHESIS OF NEW ACETAMIDE-CONJUGATED MONOBACTAM ANTIBIOTICS

In the present work, we have synthesized a new analoges of monocyclic β-lactam (2-(3-(2, 4-dichlorophenoxy)-2-(substituted aryl) - 4-oxoazetidin – 1 - ylamino) – N - (pyridin-2-yl) acetamide) derivatives in the presence of triethyl amine (TEA) and phosphorus oxychloride (POCl3) under classical method by using Dichloromethane (DCM) as a solvent. The designed compounds 4(a-l) were prepared by S...

Venkateshwarlu Jetti *, Praveen Chidurala and Jyotsna S. Meshram

Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur – 440033, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1553-61

1553-61

1934

792

28.

EFFECT OF PLASTICIZER ON STABILITY OF BUDESONIDE (C.R) MUPS PREPARED BY AQUEOUS POLYMER LAYERING

The present study was designed to investigate the effect of two different types of plasticizers, i.e., Triethyl citrate (TEC) and Acetyl tri butyl citrate on the in vitro release kinetics of Budesonide from sustained-release pellets during initial and stability conditions. Ethyl cellulose aqueous dispersion (Aqua coat ECD 30) is used as the release-retarding polymer. Both plasticizers were used at...

S. P. Borra*, K. Reddy Goli , S. Velchuri and P. C. Reddy Guntaka

Hetero Labs Ltd, Hyderabad Unit-III (R&D,B-block), IDA, Jeedimetla, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1562-67

1562-1567

2382

1048

29.

THE TREATMENT OF TRAMADOL WITH CREAM CONTAINING 3.33% DOXEPIN AND 0.05% CAPSAICIN ON THE OVERALL IMPROVEMENT OF QUALITY OF LIFE IN POST HERPETIC NEURALGIA PATIENTS

The main purpose of the study was to examine the effect of QoL of PHN patients after the treatment of tramadol (50mg-200mg), with topical cream containing 3.33% doxepin and 0.05% capsaicin and clinical correlations with CYP2D6 polymorphism. The study was prospective, non-responders versus responders, conducted in 246 outpatients of PHN undergoing tramadol treatment for 4 weeks. Rescue analgesia gi...

N. Vilas Nasare*, P. K. Mediratta, B. D. Banerjee , P. S. Deshmukh , A. K. Saxena , S. N. Bhattacharya and R. S. Ahmed

Department of Biochemistry, University College of Medical Sciences & G.T.B. Hospital, Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1568-78

1568-1578

2561

752

30.

ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF COLDENIA PROCUMBENS LINN

The methanolic extract of whole plant Coldenia procumbens was screened for its analgesic activity. The crude extract was assessed for central analgesic effect using in-vivo methods like hot plate method, tail-flick method, and tail-immersion method at two different doses. The extract at the dose of 200mg/kg body weight showed significant (p<0.001) analgesic effect comparable to the standard dru...

Santhosh Kumar Banoth*, Krishna Mohan G, Sandhya Rani M and Saba Fatima

Department of Pharmacognosy, Centre for Pharmaceutical Sciences, IST, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1579-83

1579-1583

1880

599

31.

EVALUATION OF BONE MARROW FOR HEMATOLOGICAL ANOMALIES IN INDIAN PEDIATRIC AND ADULT PATIENTS: A SINGLE TERTIARY CARE CENTER STUDY

Bone marrow aspiration can determine the metastatic deposits, degree of cellularity and fibrosis readily. A retrospective analysis of bone marrow aspiration and biopsy, in children and adult patients with hematological anomalies, were performed in 674 cases for different indication of hematological abnormalities from January 2013 to March 2014. Cases were analyzed in detail regarding clinical, hem...

Ishwar Singh , Rohit Jain , G. N. Gupta and P. K. Goyal *

Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan - 302 004, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1584-89

1584-1589

1995

682

32.

ETHNOMEDICINAL PLANTS AND THEIR CONTRIBUTION TO CURE VARIOUS AILMENTS AS HOUSEHOLD REMEDIES IN GARHWAL HIMALAYA, INDIA

The present investigation was carried out in five villages of the marginalized hill area block of Dewal in Chamoli district, regarding the uses of mild and native ethno-medicinal plants, by locals in their traditional health care system. The people residing in this area have been in isolation for centuries and possess good knowledge of phytotherapy. A total of 51 species of medicinal plants (both ...

Dhani Arya* and Ashaq Hussain Khan

Department of Botany, Kumaun University, S.S.J. Campus, Almora-263601, Uttarakhand, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1590-95

1590-1595

1844

826

33.

QUANTITATIVE ESTIMATION OF CATECHIN, QUERCETIN AND β-CAROTENE FROM POLYHERBAL FORMULATION

An HPTLC method was developed for qualitative and quantitative estimation of catechin, quercetin and β-carotene in the marketed and in house polyherbal formulation Maharishi Amrit Kalash (MAK-5). The method was developed using precoated HPTLC silica gel 60 F254 as stationary phase and toluene: ethyl acetate: formic acid (12:12:2, v/v/v) as mobile phase for catechin and quercetin and petroleum eth...

C.R. Kamath and B. Shah*

Department of Chemistry, K.J. Somaiya College of Science and Commerce, Vidyanagar, Vidyavihar, Mumbai-400077, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1596-01

1596-1601

3020

682

34.

COMPARATIVE EVALUATION OF HYPERBARIC BUPIVACAINE VERSUS ISOBARIC ROPIVACAINE IN SPINAL ANAESTHESIA IN LOWER ABDOMEN AND LOWER LIMB SURGERY

Aim of  this study was to  compare  bupivacaine  heavy ( 0.5% ) 3ml with  isobaric ropivacaine  (0.75% ) 3ml, intrathecally in patients  posted for lower abdominal  and lower limb surgery for sensory and motor effects and hemodynamic stability. 100 patients aged 12 years or older (ASA grade I, II, III) scheduled for various lower abdominal and lower limb surgeries   were randomly distrib...

Dharam S. Nanavati, Urmi Mittal Dave, Deepa Gondalia, Vandana Parmar, Vrajesh Chhaya and Ujjaval Gupta

Department of Anaesthesiology, P.D.U. Medical College, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1602-16

1602-1608

2025

690

35.

A COMPARITIVE STUDY OF PHYTOCHEMICALS AND ANTIOXIDANT ACTIVITY AMONG TRADITIONAL MEDICINAL PLANTS

Acetone extracts of the three medicinal plants Sida cardifolia, Phyllanthus amarus and Adathoda vasica were assessed for phytochemical components qualitatively and quantitatively and antioxidant activity. The results revealed that all the three contained alkaloids, carbohydrates, flavonoids, tannins, anthocyanins, steroids and phenols. Saponins were absent in all the three extracts. Sida cardifoli...

Belakere Lakshmeesh Nanda* and Thulasi T Radhakrishnan

Department of Biochemistry, Maharani’s science college for women, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1609-15

1609-1615

1757

597

36.

FREE RADICAL SCAVENGING AND HYPOGLYCEMIC POTENTIAL OF CENTRATHERUM ANTHELMINTICUM

Diabetes mellitus (DM) is a complex metabolic disease characterized by chronic hyperglycaemia commonly associated with oxidative stress. The current study aims at assessing the antioxidant and antidiabetic potential of various concentrations of hydroalcoholic extract of Centratherum anthelminticum. The in vitro antioxidant activity was assessed using 1,1-Diphenyl-2-picrilhydrazyl (DPPH), nitric ox...

Daksh Bhatia* and Sarvesh Kumar Paliwal

Department of Pharmacognosy, KIET School of Pharmacy, Ghaziabad, U.P., India

DOI: 10.13040/IJPSR.0975-8232.6(4).1616-23

1616-1623

2213

626

37.

ORAL DISINTEGRATING TABLETS OF CILOSTAZOL-HP-β-CD INCLUSION COMPLEX

Low solubility and biovariability associated with cilostazol (CLZ) pose serious formulation problems despite several advancements in dosage form design. The present research work amalgamates two different solubility enhancement techniques, viz. spray drying and cyclodextrin inclusion complexation to produce amorphous composites of CLZ with increased solubility and dissolution characteristics. FTIR...

C. Desai and B. Prabhakar *

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai- 400056, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1624-34

1624-1634

3284

1078

38.

DESIGN, SYNTHESIS AND ANTICANCER ACTIVITIES OF NOVEL UNSATURATED FATTY ACID-BASED b-HYDROXY 1,2,3-TRIAZOLES

A series of novel unsaturated fatty acid based b-hydroxy 1,2,3-triazole hybrids were designed and synthesised in excellent yields by esterification, epoxidation of oleic, ricinoleic  and 10-undecenoic acids followed by azidolysis and “click” reaction with different alkynes. All the b-hydroxy 1,2,3-triazole hybrids were characterised by ESI-MS, IR and NMR spectra as well as HRMS analysis and w...

V. Manneganti, L. Anu Prabhavathi Devi Bethala *, B. N. Prasad Rachapudi , A. Singh, R. Ummanni

Centre for Lipid Research, Indian Institute of Chemical Technology, Hyderabad , AP, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1635-49

1635-1649

1713

595

39.

EFFECT OF CLERODENDRUM INFORTUNATUM ON TESTICULAR TISSUE IN STREPTOZOTOCINE INDUCED DIABETES RATS

In diabetes, infertility is a common complication in diabetic men and experimental animals. The aim of this study was to investigate the protective effect of methanolic leaf extract of Clerodendrum infortunatum (MECI) on programmed cell death in the testicular damage resulting from streptozotocin (STZ) induced diabetes in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 ...

Pallab Kalita* and Arpita chakraborty

Assam down town University, Institute of Pharmacy, Guwahati Assam, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1650-55

1650-1655

1884

681

40.

PROTECTIVE EFFECT OF POLYHERBAL SIDDHA FORMULATION-NILAVEMBU KUDINEER AGAINST COMMON VIRAL FEVERS INCLUDING DENGUE – A CASE-CONTROL APPROACH

Nilavembu Kudineer, a Siddha Polyherbal formulation, is a decoction concentrate widely used in Siddha Medicine to combat major type(s) of fevers including viral origin such as Dengue. Methodology: Study type: Prospective case-control with Retrospective data collection. Study Setting: National Institute of Siddha – it is a central Government Siddha Hospital, located at Chennai, Tamil Nadu and con...

G. J. Christian *, M. Subramanian , D. Periyasami , K. Manickavasakam , P. Gunasekaran , S. Sivasubramanian and M. Nijavizhi

National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1656-60

1656-1660

5451

5814

41.

DEVELOPMENT AND OPTIMIZATION OF ITOPRIDE HYDROCHLORIDE FAST DISINTEGRATING TABLETS USING FACTORIAL DESIGN AND RESPONSE SURFACE METHODOLOGY

The objective of this work was to use a full factorial design and response surface methodology to optimize and prepare fast disintegrating tablets of Itopride hydrochloride (ITOHCl). Tablets were prepared by direct compression technique and evaluated for their drug content, weight variation, hardness, friability, wetting, disintegration time, and in-vitro release. In addition, the optimum formulat...

Hesham M. Tawfeek *, Jelan A. Abdel-Aleem and Mahmoud M. Ahme

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(4).1661-72

1661-1672

2003

713

42.

IMPROVED FUNCTIONALITY EXCIPIENTS FOR ORAL SOLID DOSAGE FORMS

Over the years, significant advances in the manufacturing processes of oral solid dosage forms have occurred, including the transition from tablet preparation by wet granulation to direct compression. The development of various added functionality excipients (AFEs), which are used to achieve formulations with desired end-effects, is equally important. The majority of excipients used in the manufac...

Nisha Mary Joseph*, Belay Biyena, s. Palani, and Anish Zacharia

School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

DOI: 10.13040/IJPSR.0975-8232.6(4).1673-79

1673-1679

2585

1085

43.

OPTIMIZATION OF POLYMER COATING LEVEL FOR COLON TARGETED SUSTAIN RELEASE METOPROLOL SUCCINATE PELLETS USING 32 FACTORIAL DESIGN

The present study is an attempt to minimize the dosing frequency and to target the Metoprolol succinate to the colon. Drug loaded pellets are coated with pH independent Eudragit RS100 and further coated with pH dependent Eudragit S100 in R and D pan coater. 3 2 full factorial design is applied to study the effect of extent of Eudragit S100 coating %w/w (X1) and extent of Eudragit RS100 coating %w/...

M. S. Shetage*, F. J. Sayyad and V. G. Patil

Government College of Pharmacy, Karad, Satara, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1680-92

1680-1692

1969

1324

44.

STUDY OF TOTAL PHENOLICS, TOTAL TANNINS ANTIOXIDANT POTENTIAL AND ANTIMICROBIAL ACTIVITY OF AILANTHUS EXCELSA L

Ailanthus excelsa leaves were evaluated for antimicrobial activity against clinical isolates obtained from patients with eye and skin infections and also for its antioxidant potential. The bacterial isolates obtained were identified to be S. aureus, P. aeruginosa, E. coli and the fungal isolates were identified as Aspergillus niger and Penicillium. The extract showed a maximum zone of inhibition a...

Apoorva Udayashankar and M. A. Deepa *

Department of Life Science, Kristu Jayanti College, K. Narayanapura, Bangalore 560077, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1693-97

1693-1697

2219

925

45.

ANTI-DIABETIC ACTIVITY OF SYZYGIUM POLYANTHUM (WIGHT) LEAF EXTRACT, THE MOST COMMONLY USED HERB AMONG DIABETIC PATIENTS IN MEDAN, NORTH SUMATERA, INDONESIA

Ethnopharmacological relevance: A preliminary ethnobotanical survey of diabetic patients in Health Community Centre Sering, Medan, North Sumatera, Indonesia from 2010-2011 revealed Syzygium polyanthum (Wight) as the most commonly used herb in the traditional management of diabetes mellitus. Yet, no substantial pharmacological evidences are available to validate this claim. Material and methods: A ...

Tri Widyawati , Willy Winardi Purnawan , Item Justin Atangwho , Nor Adlin Yusoff, Mariam Ahmad and Mohd. Zaini Asmawi

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia

DOI: 10.13040/IJPSR.0975-8232.6(4).1698-04

1698-1704

3745

1569

46.

ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT OF THE INK OF CUTTLEFISH, SEPIA PHARAONIS AGAINST PATHOGENIC BACTERIAL STRAINS

The aim of the present study is an attempt to evaluate the antimicrobial activity of the methanolic extract of the ink of cuttlefish, Sepia pharaonis on bacterial pathogens. The methanolic extract of the ink of cuttlefish, Sepia pharaonis were prepared and the antibacterial activity was determined by agar well diffusion method on different bacterial strains (Bacillus sp., Pseudomonas sp., E coli.,...

V. Priya Senan*

Post Graduate Department of Biotechnology, SAS SNDP Yogam College (affiliated to Mahatma Gandhi University, Kottayam), Konni, Pathanamthitta, Kerala - 689691, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1705-10

1705-1710

2824

821

47.

PROTECTIVE EFFICACY OF ALLIUM SATIVUM ON DELTAMETHRIN INDUCED TOXICITY IN REPRODUCTIVE TISSUES OF MALE MICE

Present study was carried out to assess testicular toxicity of pyrethroid insecticide, Deltamethrin (DM) in male Swiss albino mice, Mus musculus and to evaluate protective role of Allium sativum (AS) in alleviating the detrimental effect of DM. Forty male mice were divided into five experimental groups (8 mice per group) and were categorized : Control- Given distilled water and food ad libitum, Ve...

K. R. Desai, N. Moid, P. B. Patel and H. N. Highland*

Department of Zoology & Biomedical Technology, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1711-20

1711-1720

1946

1337

48.

CHEMICAL INVESTIGATION OF BIOACTIVE COMPOUNDS OF BLACK PEPPER

Black pepper (Piper nigrum) is a spice vine crop and which was used as a food preservative and as an essential component in traditional medicines. Moreover it is used also as a spice for curry cooking. The fruits and leaves may be both contains the medicinal activities. First time our concentration on to the fruits only. The fruits were collected and normally dried in the sunlight. The dried fruit...

Md. Saiful Islam *, Md. A. Noor, Md. S. Hossain, Kartik C. Saha and Haripada Seal

Department of Applied Chemistry & Chemical Engineering , Rajshahi University, Rajshahi, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.6(4).1721-26

1721-1726

2670

773

49.

COMPUTATIONAL MODELLING AND FUNCTIONAL CHARACTERIZATION OF HDAC-11

In eukaryotes, DNA is packaged into chromatin structures, whose basic unit is the nucleosome. A principle component of chromatin that plays an important role in the regulation of DNA is the modification of histones. Since histones are post-translationally modified, there inludes a large number of different histone post-translational modifications. These histone modifications create a repressive en...

L. R. Samant. *, V. C. Sangar , A. Gulamaliwala and A. S. Chowdhary

Systems Biomedicine Division, Haffkine Institute for Training, Research & Testing, Acharya Donde Marg, Parel, Mumbai. India

DOI: 10.13040/IJPSR.0975-8232.6(4).1727-35

1727-1735

2114

703

50.

AN EXPERIMENTAL EVALUATION OF ANALGESIC ACTIVITY OF TELMISARTAN

Aim and Objectives: To study the analgesic activity of telmisartan in graded doses, in tail flick method and acetic acid induced writhing method in rats and mice respectively.  Materials and Methods: Analgesic activity of telmisartan was evaluated in graded doses tail flick model (for central action) and acetic acid induced writhing model (for peripheral action) of analgesia. Aspirin & tramad...

Asha D. Jadhav*, Rakesh R. Jadhav, Sudhir L. Padwal, Vinod S. Deshmukh , Swapnil S. Jadhav , Harshal N. Pise

Department of Pharmacology, S.R.T.R. Government Medical College Ambajogai, MH, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1736-40

1736-1740

1980

720

51.

A COMPARATIVE STUDY OF ANTIFUNGAL ACTIVITY OF ALSTONIA VENENATA R. BR

Alstonia venenata a member of the family Apocynaceae, finds a prominent place in Ayurveda system of medicine and also among different tribal groups in India for a variety of diseases such as fever, epilepsy, malaria and a variety of skin diseases. A.venenata was studied to investigate the bioactive properties. Various plant parts like leaves, stem-bark, root-bark, flowers and fruits were extracted...

S. K. Thomas, M. Kunjumon, R. E. George, and T. VaidyanathaIyer *

Department of Biotechnology, University of Kerala, Kariyavattom, Thiruvananthapuram 695581, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1741-45

1741-1745

1845

783

52.

FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLETS USING 32 FACTORIAL DESIGN

The main objective of present investigation is to formulate the sustained release tablet of lamotrigine using 32 factorial design. Lamotrigine, a weakly basic and anticonvulsant drug belongs to BCS Class II, having high permeability and poor solubility.  The sustained release tablets of lamotrigine were prepared employing different concentrations of HPMC K4M and HPMC K100M in different combinatio...

Raghavendra Kumar Gunda*, J. N. Suresh Kumar, Ch Ajay Babu and M. V. Anjaneyulu

Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopet, Guntur (Dt) - 522601, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1746-52

1746-1752

3374

951

53.

ANXIOLYTIC AND MOTOR COORDINATION ACTIVITY OF ETHANOLIC AND AQUEOUS EXTRACTS OF DENDROPHTHOE FALCATA LEAVES IN MICE

The aim of the present study was to evaluate the anxiolytic effects and motor activity of ethanolic and aqueous extracts of leaves of Dendrophthoe falcata (DF) in mice. Swiss albino mice were treated orally with ethanolic and aqueous extracts of DF leaves (250 mg/kg and 500 mg/kg) and distilled water along with alprazolam (1 mg/kg) intraperitoneally for seven days and then exposed to Elevated Plus...

Dinesh Aryal* and Nadeem Khan

Swift School of Pharmacy, Ghaggar Sarai, Rajpura, Patiala (Punjab) 140401, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1753-60

1753-1760

2096

810

54.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF SOME NEW SUBSTITUTED IMIDAZOLES

In the present study, a new series of 2, 4, 5- trisubstituted imidazoles derivatives were synthesized taking different aldehydes as substitutions. The preliminary characterization of synthesized compounds identified by physical constants determination and TLC. The chemical structures were confirmed by means of IR, 1H-NMR and Mass spectral data. The synthesized compounds were screened for their ant...

R. Rambabu, J. Subbarao,* and P. Pavan Kumar

Department of Pharmaceutical Chemistry, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, A.P., India

DOI: 10.13040/IJPSR.0975-8232.6(4).1761-65

1761-1765

2700

1040

55.

EVALUATION OF ANTIMICROBIAL ACTIVITIES AND DNA-BINDING PROPERTIES OF MOLYBDENUM COMPLEXES

Molybdenum is a trace element distributed widely in nature which plays an important role in plant and animal nutrition and in our industrial society. Molybdenum is essentially present in the enzymes nitrogenase,    Xanthine-oxidase, sulphite oxidas, nitrate reductase, formate dehydrogenase and aldehyde oxidase. These enzymes are responsible for a number of catalytic reactions of redox nature. M...

V. K. Srivastava

Chemical Research Laboratory, Department of Chemistry, D.S. College, Aligarh-202001, U.P., India

DOI: 10.13040/IJPSR.0975-8232.6(4).1766-70

1766-1770

1562

627

56.

EVIDENCE FOR COMPLEX FORMATION OF IBUPROFEN WITH GO-GHRITA

Present investigation provides evidence for complex formation of Ibuprofen (Ib) with Go-Ghrita (GG).  Ibuprofen binary mixture in (1:0.5), (1:1), (1:2), (1:3) w/w proportions were prepared by adding to molten Go-Ghrita kept over a water bath at 65-70oC with continuous stirring. Organoleptic and Physico-chemical properties of GG (procured from Magan Sangrahalaya, Wardha) were as per the specificat...

R. D. Bawankar *, D. M. Sakarkar and A. K. Dorle

Sudhakarrao Naik Institute of Pharmacy, Nagpur Road, Pusad (M.S.), India

DOI: 10.13040/IJPSR.0975-8232.6(4).1771-78

1771-1778

1713

844

57.

SAFETY AND ADVERSE EVENTS OF PROPHYLACTIC HPV VACCINES AMONG HEALTHY WOMEN: A SYSTEMATIC REVIEW & META ANALYSIS

Cervical cancer (CaCx) is the third most common female cancer worldwide with an estimated 5, 27, 624 new cases and 2, 65, 653 deaths in 2014. We conducted a systematic review and meta- analysis to assess safety of prophylactic HPV vaccines compared against placebo. Four unique trials were included out of 607 publications. The total patient data evaluated was 1427(852 in vaccinated arm; 575 in the ...

V. C. Sangar *, B. B. Ghongane , G. Mathur and A. S. Chowdhary

B. J. Govt. Medical College and Sassoon General Hospital, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1779-91

1779-1791

1572

664

58.

SYNTHESIS AND EVALUATION OF NOVEL THIOSEMICARBAZONE DERIVATIVES AS ANTICANCER AGENTS

:  Thiosemicarbazobes are the compounds that possess wide range of biological activities. Presently the areas in which thiosemicarbazones receiving more attention is its use against cancer. Reports from the SAR studies confirms that the thiosemicarbazones with heterocyclic moiety shows carcinogenic potency. These are potent ribonucleotide reductase inhibitor. Adamantyl derivatives is also having ...

Niharika Gokhale * and Sanjay Jain

Department of Pharmaceutical Sciences, Gyan vihar University, Jaipur Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1792-04

1792-1804

2018

749

59.

ANTIMICROBIAL PROFILE OF RHODOCOCCUS ERYTHROPOLIS VL-RK_05 ISOLATED FROM MANGO ORCHARDS

The aim of the present study was to isolate, identify and to analyze the phylogenetic characteristics of the potent actinobacterial strain VL-RK_05 isolated from Mango orchards of Vissannapet, Krishna Dist, Andhra Pradesh. Soil samples collected were pre treated with calcium carbonate and used for isolation of potent Actinobacterial strain designated as VL-RK_05. Identification of the strain was c...

Rajesh Kumar Munaganti, Krishna Naragani and Vijayalakshmi Muvva*

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.6(4).1805-12

1805-1812

1834

683

60.

EVALUATION OF THE ANTI-ANGIOGENIC AND ANTIOXIDANT ACTIVITY OF INDIAN HONEYS IN COMPARISON WITH MANUKA HONEY FROM NEW ZEALAND

Honey possesses a wide range of medicinal properties due to presence of phytochemicals including flavonoids and phenolic acids. Free radicals and process of angiogenesis are one of the major contributors to cancer development and the use of phytoconstituents as reactive oxygen species scavengers and as an antiangiogenic moiety has clinical potential and may be having less negative side effects tha...

A. A. Naik*, O. D. Juwekar, P. V. Ansulkar, S. D. Deshpande and A. S. Chowdhary

Haffkine Institute for Training, Research and Testing, Acharya donde marg, Parel, Mumbai- 400012, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(4).1813-18

1813-1818

2140

844