Volume 6 (2015) - Issue 4, April
PHARMACOLOGICAL OVERVIEW OF FREEZE DRIED ANDAMAN NONI (MORINDA CITRIFOLIA.L) AGAINST CANCER AND NEUROLOGICAL DISORDER
Noni (Morinda citrifolia) is one of the important traditional medicinal plants have been used by Polynesia over a period of 2000 years. Morinda citrifolia belongs to family Rubiaceae (Coffee family) which is an evergreen small sized tree, with glossy and deeply veined leaves found in tropical regions and islands of South Pacific, West Indies, India, Africa, and Australia. Noni fruit juice tradit...
MULTIUNIT FLOATING DRUG DELIVERY SYSTEM A SIGNIFICANT TOOL FOR THE TREATMENT OF PEPTIC ULCER DISEASE
The gastroretentive drug delivery system has been utilized to obtain prolonged and uniform release of drug in stomach. Thus increase bioavailability and decrease the administration frequency. A peptic ulcer is a break in the lining of the stomach, esophagus or duodenum. Peptic ulcer may be due to H. Pylori bacteria, acid of the stomach cell or nonsteroidal anti-inflammatory drugs (NSAIDS). The gas...
NANOEMULSIONS: A VERSATILE DRUG DELIVERY TOOL
Since last decade, the interdisciplinary research of Nanoemulsions (NEs) have gained great attention in research and drug designing owing to their promising range of applications in the field of pharmaceutics, drug delivery through different route, cosmetics, to name a few. In addition to the small droplet size these non-equilibrium liquid systems have interesting properties including optical clar...
PHARMACOLOGICAL AND PHYTOCHEMICAL REVIEW ON ACTINIOPTERIS RADIATA.
Herbal medicines are precious and valuable gift of nature. Indian system of medicine viz. Ayurveda is much prevailing in our country, which comprises of various traditional medicines. The practice of medicinal herbs for treating the diseases is very well known from ancient time. Actiniopteris australis (Syn: A. radiata; A. Dichotoma), is a xerophytic species of the fern family Actiniopteridaceae ,...
SUBACUTE ANTIDIABETIC PROPERTIES OF AGERATUM CONYZOIDES LEAVES IN DIABETIC RATS
This study investigated the antidiabetic activity of the aqueous extract of the leaves of Ageratum conyzoides. Streptozotocin induced hyperglycemia male adult albino rats were used to study the antidiabetic effect of Ageratum conyzoides aqueous extract (at doses of 100, 200 and 300 mg/kg respectively). The diabetic rats were housed in metabolic cages, for the whole period of the experiment. Body w...
RIVAROXABAN IMPROVES MYOCARDIAL ISCHEMIA REPERFUSION INJURY COMPLICATIONS IN OBESE RATS
Rivaroxaban is a direct inhibitor for Factor Xa that used orally for prevention and treatment of thromboembolic disorders through inhibition of thrombin synthesis. In this study we hypothesis that rivaroxaban pretreatment might play a role in reducing the complications of myocardial ischemic reperfusion injury (IRI) in a rat model of obesity. R- hirudin (a commercially available anticoagulant drug...
IDENTIFICATION OF GENES EXPRESSED DURING WATER STRESS IN FOUQUIERIA SPLENDENS SSP. BREVIFLORA
We identified genes in Fouquieria splendens ssp. breviflora (Fouquieriaceae) that were expressed due to water deficits. RNA was extracted from dehydrated stem samples that were collected directly from Camargo, Querétaro following hydration for two weeks. The plants were grown in two states, drought and hydrated. We then performed subtractive hybridization. The obtained sequences were inserted int...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DETERMINATION OF LEVOFLOXACIN IN TABLET USING UV AND FLUORESCENCE DETECTORS SIMELTANIOUSLY
Simple, sensitive, precise, accurate, and specific reversed –phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of levofloxacinin pharmaceutical tablets. Levofloxacin is a third generation fluoroquinolones with a wide spectrum of action against gram-positive and gram-negative bacteria, anaerobic microorganisms and atypical pathogens. I...
NUTRIENT CONTENT AND ANTIOXIDANT PROPERTIES OF SOME POPULAR FRUITS IN BANGLADESH
The present study discussed the nutritional content and quantification of eleven bioactive phenolic antioxidant contents in the water, methanol and acetone extracts of four different edible fruits viz. Musa acuminate (banana), Ananascomosus (pineapple), Psidiumguajava (guava) and Malusdomestica (apple) using HPLC-DAD. Nutritional analysis showed that the most moisture and fiber-containing fruit wa...
HEPATOPROTECTIVE ACTIVITY OF FICUS DALHOUSIAE MIQ LEAVES ETHANOLIC EXTRACT ON CARBON TETRACHLORIDE AND PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS
Leaves and bark preparations of Ficus dalhousiae Miq (Moraceae) are used in folklore and Siddha system of medicine for liver and skin ailments. So the intent of the present study was to evaluate the Hepatoprotective effect of Ficus dalhousiae Miq leaves ethanolic extract (FDLEE) by means of Carbon tetrachloride and Paracetamol induced hepatotoxicity model in Albino rats. Administration of carbon t...
EVALUATION OF PHYTOCHEMICAL, ANTIOXIDANT, ANTHELMINTIC AND ANTIMICROBIAL PROPERTIES OF CRATAEVA NURVALA BUCH. HAM. LEAVES
The aim of this study was to determine principle phytochemical classes and total phenolic contents and to investigate antioxidant, anthelmintic and antimicrobial activities of ethanolic extract of Crataeva nurvala leaves. Standard test methodology suitable for each chemical class was followed to screen out major chemical classes preliminarily. The total phenolic content of ethanolic leaf extract w...
ANTIOXIDANT AND HAEMATOPROTECTIVE ACTIVITY OF THE SARACA INDICA STEM BARK
Present study was designed to evaluate the antioxidant and hematoprotective activity of methanolic extract of saraca indica bark. Antioxidants and hematoprotective effect of saraca indica bark may be due to its polyphenolic compounds. Polyphenols act as reducing agents via scavenging of free radicals and chelation of transition metals. The hematoprotective activity of Saraca indica was studied in ...
EVALUATION OF THE IMMUNOMODULATORY ACTIVITY OF THE ROOTS OF ICHNOCARPUS FRUTESCENS
The objective of the present study was to investigate the immunomodulatory activity of the roots of Ichnocarpus frutescents R.Br. In the present study Pet. Ether, Chloroform and Methanolic fractions of the ethanolic extract of the roots of Ichnocarpus frutescens, in the doses of 10mg/kg and 30mg/kg, were administered orally to evaluate the immunomodulatory activity. The Methanolic fraction in the ...
FORMULATION AND EVALUATION OF CHRONOMODULATED COLONIC DRUG DELIVERY OF NIFIDIPINE
The pulsatile drug delivery works upon the system that releases active pharmaceutical ingredient completely and rapidly after a desired lag time. This type of approach was advantageous for: Drugswith extensive first pass metabolism and biological tolerance. Locally absorbed or acting drugs to a specific site in the intestinal tract (e.g. colon). Adaptation of therapy according to chronopharmacolog...
PHYTOCHEMICAL INVESTIGATIONS AND ANATOMICAL STUDY OF TWO SPECIES OF CALOTROPIS FROM CHANDIGARH
Medicinal plants have been used since prehistoric period for the cure of various diseases. Hence the herbal medicines occupy distinct position right from the primitive period to present day. Calotropis procera, a wild growing plant of family Asclepiadaceae, is well known for its medicinal properties. Different parts of this plant have been reported to exhibit anti-inflammatory, analgesic, and anti...
SUITABILITY OF DIFFERENT GRADES OF GELUCIRE AND PEG-6000 FOR SOLUBILITY ENHANCEMENT OF TINIDAZOLE BY PROCESS OF SOLID DISPERSION
Tinidazole is a synthetic antiprotozoal and antibacterial agent which is practically insoluble in water.Oral dose of tinidazole is very high (2gm) owing to its limited solubility. Present research focuses on enhancement of solubility of tinidazole using the technique of solid dispersion which is reported to be one of the simple technique for solubility enhancement using various grades of Gelucire ...
AMELIORATIVE EFFECT OF PUNICA GRANATUM L. AGAINST BLEOMYCIN INDUCED PULMONARY FIBROSIS IN RATS
Aim: Bleomycin (BLM), a potent anticancer agent widely used in the treatment of cancer is an antibiotic isolated from Streptomyces verticillus. BLM has been reported to cause pulmonary fibrosis that limits the chemotherapeutic efficiency. The present study aims to evaluate the efficacy of the aqueous extract of pomegranate (Punica granatum) against BLM induced pulmotoxicity in rats. Methods: The...
ANTI-INFLAMMATORY ACTIVITY OF CROCUS SATIVUS EXTRACT IN EXPERIMENTAL ARTHRITIS
Rheumatoid arthritis is one of the most serious medical problems leading to bone and cartilage destruction. The disease affects approximately 1% of the total world population. Mostly the women are affected. The pathogenesis of the disease is still not clearly understood. Free radicals and inflammatory molecules such as TNF-α, IL-1β etc have been recognized as major players in the progression of ...
CYTOGENETIC STUDY OF CHROMOSOMAL ABERRATIONS ASSOCIATED WITH ACUTE LEUKEMIA
The most common cause of death is bone marrow failure. Chromosomal analysis is essential for the diagnosis, response to treatment and prognosis of leukemia. Conventional karyotyping which shows the structural, numerical and compound aberrations have improved the genetic diagnosis of leukemia. The bone marrow samples from patients (2-60yrs) of 53 patients (32 male and 21 female) suffering from vari...
NEUROPATHIC PAIN SYMPTOMS OF POST HERPETIC NEURALGIA PATIENTS WITH CYP2D6 POLYMORPHISM UNDERGOING TRAMADOL TREATMENT
Main aim of this study was to find out relation of CYP2D6 polymorphism with tramadol action in post herpetic neuralgia (PHN) patients. This non- responders versus responders study mainly includes 246 patients (age group 20-80 years) of PHN, assigned into two groups depending upon their response to tramadol treatment at the end of 2nd week of drug therapy. On the basis of CYP2D6 polymorphism, an al...
EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC LEAVES EXTRACT OF LASIA SPINOSA AND ITS ROLE IN PREVENTION OF HYPERLIPIDEMIA INDUCED PANCREATITIS IN RATS
Leaves, rootstock, fruit and decoction of Lasia spinosa (Araceae) are used in folklore medicine for Gastrointestinal, Respiratory and Skin diseases. The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Lasia spinosa and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The evaluation of the Antihyperlipidemic a...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR QUANTITATIVE DETERMINATION OF RELATED SUBSTANCES PRESENT IN ELETRIPTAN HYDROBROMIDE DRUG SUBSTANCE
An efficient and sensitive RP-HPLC method was developed and validated for the estimation of related substances in Eletriptan hydrobromide drug substance which were identified and characterized by LCMS, FTIR, 1HNMR, 13CNMR techniques. The method was carried out on a Purosphere STAR RP-8e column at temperature 20°C using a phosphate buffer at pH 4.0 and solvent mixture consists of acetonitrile, wat...
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES ON DIVERSE STRUCTURAL CLASSES OF NATURAL FLAVONOIDS AS AMV AND HIV REVERSE TRANSCRIPTASE INHIBITORS USING CoMFA AND CoMSIA
In this study, comparative molecular ﬁeld analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on a series of 73 experimentally reported natural flavonoid derivatives as AMV and HIV Reverse transcriptase (RT) inhibitors with pIC50 values ranging from 4.00 to 5.92. Based on alignment, highly predictive CoMFA and CoMSIA were obtained with cross-validated q...
STUDY OF DISSOLUTION CHARACTERISTICS OF IBUPROFEN BY DIFFERENT POLYMERS AND SOLID DISPERSION TECHNIQUES
Poor water solubility is characterized by low dissolution rate and consequently reduced bioavailability. Formulation of solid dispersion has attracted considerable interest where dispersing a poorly water soluble drug in a water soluble polymer matrix improves the dissolution characteristics and bioavailability of the drug. The aim of the present study was to enhance the dissolution rate and bioav...
THERAPEUTIC EFFICACY OF VERNONIA CINEREA IN SELENITE INDUCED CATARACT MODELS
We have evaluated the efficacy of methanolic extract of Vernonia cinerea (MEVC) in selenite induced cataract using Sprague Dawley rats. Previous reports suggest that phytochemicals or natural plant products retard the process of cataractogenesis by scavenging free oxygen radicals. Hence, the present study sought to assess the potential of MEVC on in vivo selenite induced cataract models. The antio...
EVALUATION OF ANTIMICROBIAL ACTIVITY OF PLANT EXTRACTS
The objective of this study was to evaluate the possible antimicrobial properties of water, methanol, chloroform and Petroleum ether extracts of leaves of different Indian medicinal plants including Mangifera indica Linn, Ixora parviflora Vahl, Psydium guajava Linn, Calotropis procera Ait. The extracts were investigated individually for in vitro antibacterial activity by cup plate (well diffusion)...
SYNTHESIS OF NEW ACETAMIDE-CONJUGATED MONOBACTAM ANTIBIOTICS
In the present work, we have synthesized a new analoges of monocyclic β-lactam (2-(3-(2, 4-dichlorophenoxy)-2-(substituted aryl) - 4-oxoazetidin – 1 - ylamino) – N - (pyridin-2-yl) acetamide) derivatives in the presence of triethyl amine (TEA) and phosphorus oxychloride (POCl3) under classical method by using Dichloromethane (DCM) as a solvent. The designed compounds 4(a-l) were prepared by S...
EFFECT OF PLASTICIZER ON STABILITY OF BUDESONIDE (C.R) MUPS PREPARED BY AQUEOUS POLYMER LAYERING
The present study was designed to investigate the effect of two different types of plasticizers, i.e., Triethyl citrate (TEC) and Acetyl tri butyl citrate on the in vitro release kinetics of Budesonide from sustained-release pellets during initial and stability conditions. Ethyl cellulose aqueous dispersion (Aqua coat ECD 30) is used as the release-retarding polymer. Both plasticizers were used at...
THE TREATMENT OF TRAMADOL WITH CREAM CONTAINING 3.33% DOXEPIN AND 0.05% CAPSAICIN ON THE OVERALL IMPROVEMENT OF QUALITY OF LIFE IN POST HERPETIC NEURALGIA PATIENTS
The main purpose of the study was to examine the effect of QoL of PHN patients after the treatment of tramadol (50mg-200mg), with topical cream containing 3.33% doxepin and 0.05% capsaicin and clinical correlations with CYP2D6 polymorphism. The study was prospective, non-responders versus responders, conducted in 246 outpatients of PHN undergoing tramadol treatment for 4 weeks. Rescue analgesia gi...
ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF COLDENIA PROCUMBENS LINN
The methanolic extract of whole plant Coldenia procumbens was screened for its analgesic activity. The crude extract was assessed for central analgesic effect using in-vivo methods like hot plate method, tail-flick method, and tail-immersion method at two different doses. The extract at the dose of 200mg/kg body weight showed significant (p<0.001) analgesic effect comparable to the standard dru...
EVALUATION OF BONE MARROW FOR HEMATOLOGICAL ANOMALIES IN INDIAN PEDIATRIC AND ADULT PATIENTS: A SINGLE TERTIARY CARE CENTER STUDY
Bone marrow aspiration can determine the metastatic deposits, degree of cellularity and fibrosis readily. A retrospective analysis of bone marrow aspiration and biopsy, in children and adult patients with hematological anomalies, were performed in 674 cases for different indication of hematological abnormalities from January 2013 to March 2014. Cases were analyzed in detail regarding clinical, hem...
ETHNOMEDICINAL PLANTS AND THEIR CONTRIBUTION TO CURE VARIOUS AILMENTS AS HOUSEHOLD REMEDIES IN GARHWAL HIMALAYA, INDIA
The present investigation was carried out in five villages of the marginalized hill area block of Dewal in Chamoli district, regarding the uses of mild and native ethno-medicinal plants, by locals in their traditional health care system. The people residing in this area have been in isolation for centuries and possess good knowledge of phytotherapy. A total of 51 species of medicinal plants (both ...
QUANTITATIVE ESTIMATION OF CATECHIN, QUERCETIN AND β-CAROTENE FROM POLYHERBAL FORMULATION
An HPTLC method was developed for qualitative and quantitative estimation of catechin, quercetin and β-carotene in the marketed and in house polyherbal formulation Maharishi Amrit Kalash (MAK-5). The method was developed using precoated HPTLC silica gel 60 F254 as stationary phase and toluene: ethyl acetate: formic acid (12:12:2, v/v/v) as mobile phase for catechin and quercetin and petroleum eth...
COMPARATIVE EVALUATION OF HYPERBARIC BUPIVACAINE VERSUS ISOBARIC ROPIVACAINE IN SPINAL ANAESTHESIA IN LOWER ABDOMEN AND LOWER LIMB SURGERY
Aim of this study was to compare bupivacaine heavy ( 0.5% ) 3ml with isobaric ropivacaine (0.75% ) 3ml, intrathecally in patients posted for lower abdominal and lower limb surgery for sensory and motor effects and hemodynamic stability. 100 patients aged 12 years or older (ASA grade I, II, III) scheduled for various lower abdominal and lower limb surgeries were randomly distrib...
A COMPARITIVE STUDY OF PHYTOCHEMICALS AND ANTIOXIDANT ACTIVITY AMONG TRADITIONAL MEDICINAL PLANTS
Acetone extracts of the three medicinal plants Sida cardifolia, Phyllanthus amarus and Adathoda vasica were assessed for phytochemical components qualitatively and quantitatively and antioxidant activity. The results revealed that all the three contained alkaloids, carbohydrates, flavonoids, tannins, anthocyanins, steroids and phenols. Saponins were absent in all the three extracts. Sida cardifoli...
FREE RADICAL SCAVENGING AND HYPOGLYCEMIC POTENTIAL OF CENTRATHERUM ANTHELMINTICUM
Diabetes mellitus (DM) is a complex metabolic disease characterized by chronic hyperglycaemia commonly associated with oxidative stress. The current study aims at assessing the antioxidant and antidiabetic potential of various concentrations of hydroalcoholic extract of Centratherum anthelminticum. The in vitro antioxidant activity was assessed using 1,1-Diphenyl-2-picrilhydrazyl (DPPH), nitric ox...
ORAL DISINTEGRATING TABLETS OF CILOSTAZOL-HP-β-CD INCLUSION COMPLEX
Low solubility and biovariability associated with cilostazol (CLZ) pose serious formulation problems despite several advancements in dosage form design. The present research work amalgamates two different solubility enhancement techniques, viz. spray drying and cyclodextrin inclusion complexation to produce amorphous composites of CLZ with increased solubility and dissolution characteristics. FTIR...
DESIGN, SYNTHESIS AND ANTICANCER ACTIVITIES OF NOVEL UNSATURATED FATTY ACID-BASED b-HYDROXY 1,2,3-TRIAZOLES
A series of novel unsaturated fatty acid based b-hydroxy 1,2,3-triazole hybrids were designed and synthesised in excellent yields by esterification, epoxidation of oleic, ricinoleic and 10-undecenoic acids followed by azidolysis and “click” reaction with different alkynes. All the b-hydroxy 1,2,3-triazole hybrids were characterised by ESI-MS, IR and NMR spectra as well as HRMS analysis and w...
EFFECT OF CLERODENDRUM INFORTUNATUM ON TESTICULAR TISSUE IN STREPTOZOTOCINE INDUCED DIABETES RATS
In diabetes, infertility is a common complication in diabetic men and experimental animals. The aim of this study was to investigate the protective effect of methanolic leaf extract of Clerodendrum infortunatum (MECI) on programmed cell death in the testicular damage resulting from streptozotocin (STZ) induced diabetes in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 ...
PROTECTIVE EFFECT OF POLYHERBAL SIDDHA FORMULATION-NILAVEMBU KUDINEER AGAINST COMMON VIRAL FEVERS INCLUDING DENGUE – A CASE-CONTROL APPROACH
Nilavembu Kudineer, a Siddha Polyherbal formulation, is a decoction concentrate widely used in Siddha Medicine to combat major type(s) of fevers including viral origin such as Dengue. Methodology: Study type: Prospective case-control with Retrospective data collection. Study Setting: National Institute of Siddha – it is a central Government Siddha Hospital, located at Chennai, Tamil Nadu and con...
DEVELOPMENT AND OPTIMIZATION OF ITOPRIDE HYDROCHLORIDE FAST DISINTEGRATING TABLETS USING FACTORIAL DESIGN AND RESPONSE SURFACE METHODOLOGY
The objective of this work was to use a full factorial design and response surface methodology to optimize and prepare fast disintegrating tablets of Itopride hydrochloride (ITOHCl). Tablets were prepared by direct compression technique and evaluated for their drug content, weight variation, hardness, friability, wetting, disintegration time, and in-vitro release. In addition, the optimum formulat...
IMPROVED FUNCTIONALITY EXCIPIENTS FOR ORAL SOLID DOSAGE FORMS
Over the years, significant advances in the manufacturing processes of oral solid dosage forms have occurred, including the transition from tablet preparation by wet granulation to direct compression. The development of various added functionality excipients (AFEs), which are used to achieve formulations with desired end-effects, is equally important. The majority of excipients used in the manufac...
OPTIMIZATION OF POLYMER COATING LEVEL FOR COLON TARGETED SUSTAIN RELEASE METOPROLOL SUCCINATE PELLETS USING 32 FACTORIAL DESIGN
The present study is an attempt to minimize the dosing frequency and to target the Metoprolol succinate to the colon. Drug loaded pellets are coated with pH independent Eudragit RS100 and further coated with pH dependent Eudragit S100 in R and D pan coater. 3 2 full factorial design is applied to study the effect of extent of Eudragit S100 coating %w/w (X1) and extent of Eudragit RS100 coating %w/...
STUDY OF TOTAL PHENOLICS, TOTAL TANNINS ANTIOXIDANT POTENTIAL AND ANTIMICROBIAL ACTIVITY OF AILANTHUS EXCELSA L
Ailanthus excelsa leaves were evaluated for antimicrobial activity against clinical isolates obtained from patients with eye and skin infections and also for its antioxidant potential. The bacterial isolates obtained were identified to be S. aureus, P. aeruginosa, E. coli and the fungal isolates were identified as Aspergillus niger and Penicillium. The extract showed a maximum zone of inhibition a...
ANTI-DIABETIC ACTIVITY OF SYZYGIUM POLYANTHUM (WIGHT) LEAF EXTRACT, THE MOST COMMONLY USED HERB AMONG DIABETIC PATIENTS IN MEDAN, NORTH SUMATERA, INDONESIA
Ethnopharmacological relevance: A preliminary ethnobotanical survey of diabetic patients in Health Community Centre Sering, Medan, North Sumatera, Indonesia from 2010-2011 revealed Syzygium polyanthum (Wight) as the most commonly used herb in the traditional management of diabetes mellitus. Yet, no substantial pharmacological evidences are available to validate this claim. Material and methods: A ...
ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT OF THE INK OF CUTTLEFISH, SEPIA PHARAONIS AGAINST PATHOGENIC BACTERIAL STRAINS
The aim of the present study is an attempt to evaluate the antimicrobial activity of the methanolic extract of the ink of cuttlefish, Sepia pharaonis on bacterial pathogens. The methanolic extract of the ink of cuttlefish, Sepia pharaonis were prepared and the antibacterial activity was determined by agar well diffusion method on different bacterial strains (Bacillus sp., Pseudomonas sp., E coli.,...
PROTECTIVE EFFICACY OF ALLIUM SATIVUM ON DELTAMETHRIN INDUCED TOXICITY IN REPRODUCTIVE TISSUES OF MALE MICE
Present study was carried out to assess testicular toxicity of pyrethroid insecticide, Deltamethrin (DM) in male Swiss albino mice, Mus musculus and to evaluate protective role of Allium sativum (AS) in alleviating the detrimental effect of DM. Forty male mice were divided into five experimental groups (8 mice per group) and were categorized : Control- Given distilled water and food ad libitum, Ve...
CHEMICAL INVESTIGATION OF BIOACTIVE COMPOUNDS OF BLACK PEPPER
Black pepper (Piper nigrum) is a spice vine crop and which was used as a food preservative and as an essential component in traditional medicines. Moreover it is used also as a spice for curry cooking. The fruits and leaves may be both contains the medicinal activities. First time our concentration on to the fruits only. The fruits were collected and normally dried in the sunlight. The dried fruit...
COMPUTATIONAL MODELLING AND FUNCTIONAL CHARACTERIZATION OF HDAC-11
In eukaryotes, DNA is packaged into chromatin structures, whose basic unit is the nucleosome. A principle component of chromatin that plays an important role in the regulation of DNA is the modification of histones. Since histones are post-translationally modified, there inludes a large number of different histone post-translational modifications. These histone modifications create a repressive en...
AN EXPERIMENTAL EVALUATION OF ANALGESIC ACTIVITY OF TELMISARTAN
Aim and Objectives: To study the analgesic activity of telmisartan in graded doses, in tail flick method and acetic acid induced writhing method in rats and mice respectively. Materials and Methods: Analgesic activity of telmisartan was evaluated in graded doses tail flick model (for central action) and acetic acid induced writhing model (for peripheral action) of analgesia. Aspirin & tramad...
A COMPARATIVE STUDY OF ANTIFUNGAL ACTIVITY OF ALSTONIA VENENATA R. BR
Alstonia venenata a member of the family Apocynaceae, finds a prominent place in Ayurveda system of medicine and also among different tribal groups in India for a variety of diseases such as fever, epilepsy, malaria and a variety of skin diseases. A.venenata was studied to investigate the bioactive properties. Various plant parts like leaves, stem-bark, root-bark, flowers and fruits were extracted...
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLETS USING 32 FACTORIAL DESIGN
The main objective of present investigation is to formulate the sustained release tablet of lamotrigine using 32 factorial design. Lamotrigine, a weakly basic and anticonvulsant drug belongs to BCS Class II, having high permeability and poor solubility. The sustained release tablets of lamotrigine were prepared employing different concentrations of HPMC K4M and HPMC K100M in different combinatio...
ANXIOLYTIC AND MOTOR COORDINATION ACTIVITY OF ETHANOLIC AND AQUEOUS EXTRACTS OF DENDROPHTHOE FALCATA LEAVES IN MICE
The aim of the present study was to evaluate the anxiolytic effects and motor activity of ethanolic and aqueous extracts of leaves of Dendrophthoe falcata (DF) in mice. Swiss albino mice were treated orally with ethanolic and aqueous extracts of DF leaves (250 mg/kg and 500 mg/kg) and distilled water along with alprazolam (1 mg/kg) intraperitoneally for seven days and then exposed to Elevated Plus...
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF SOME NEW SUBSTITUTED IMIDAZOLES
In the present study, a new series of 2, 4, 5- trisubstituted imidazoles derivatives were synthesized taking different aldehydes as substitutions. The preliminary characterization of synthesized compounds identified by physical constants determination and TLC. The chemical structures were confirmed by means of IR, 1H-NMR and Mass spectral data. The synthesized compounds were screened for their ant...
EVALUATION OF ANTIMICROBIAL ACTIVITIES AND DNA-BINDING PROPERTIES OF MOLYBDENUM COMPLEXES
Molybdenum is a trace element distributed widely in nature which plays an important role in plant and animal nutrition and in our industrial society. Molybdenum is essentially present in the enzymes nitrogenase, Xanthine-oxidase, sulphite oxidas, nitrate reductase, formate dehydrogenase and aldehyde oxidase. These enzymes are responsible for a number of catalytic reactions of redox nature. M...
EVIDENCE FOR COMPLEX FORMATION OF IBUPROFEN WITH GO-GHRITA
Present investigation provides evidence for complex formation of Ibuprofen (Ib) with Go-Ghrita (GG). Ibuprofen binary mixture in (1:0.5), (1:1), (1:2), (1:3) w/w proportions were prepared by adding to molten Go-Ghrita kept over a water bath at 65-70oC with continuous stirring. Organoleptic and Physico-chemical properties of GG (procured from Magan Sangrahalaya, Wardha) were as per the specificat...
SAFETY AND ADVERSE EVENTS OF PROPHYLACTIC HPV VACCINES AMONG HEALTHY WOMEN: A SYSTEMATIC REVIEW & META ANALYSIS
Cervical cancer (CaCx) is the third most common female cancer worldwide with an estimated 5, 27, 624 new cases and 2, 65, 653 deaths in 2014. We conducted a systematic review and meta- analysis to assess safety of prophylactic HPV vaccines compared against placebo. Four unique trials were included out of 607 publications. The total patient data evaluated was 1427(852 in vaccinated arm; 575 in the ...
SYNTHESIS AND EVALUATION OF NOVEL THIOSEMICARBAZONE DERIVATIVES AS ANTICANCER AGENTS
: Thiosemicarbazobes are the compounds that possess wide range of biological activities. Presently the areas in which thiosemicarbazones receiving more attention is its use against cancer. Reports from the SAR studies confirms that the thiosemicarbazones with heterocyclic moiety shows carcinogenic potency. These are potent ribonucleotide reductase inhibitor. Adamantyl derivatives is also having ...
ANTIMICROBIAL PROFILE OF RHODOCOCCUS ERYTHROPOLIS VL-RK_05 ISOLATED FROM MANGO ORCHARDS
The aim of the present study was to isolate, identify and to analyze the phylogenetic characteristics of the potent actinobacterial strain VL-RK_05 isolated from Mango orchards of Vissannapet, Krishna Dist, Andhra Pradesh. Soil samples collected were pre treated with calcium carbonate and used for isolation of potent Actinobacterial strain designated as VL-RK_05. Identification of the strain was c...
EVALUATION OF THE ANTI-ANGIOGENIC AND ANTIOXIDANT ACTIVITY OF INDIAN HONEYS IN COMPARISON WITH MANUKA HONEY FROM NEW ZEALAND
Honey possesses a wide range of medicinal properties due to presence of phytochemicals including flavonoids and phenolic acids. Free radicals and process of angiogenesis are one of the major contributors to cancer development and the use of phytoconstituents as reactive oxygen species scavengers and as an antiangiogenic moiety has clinical potential and may be having less negative side effects tha...