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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Volume 11 (2020) - Issue 5, May

Review Articles

 
Title
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1.

AN OVERVIEW ON COVID-19 OUTBREAK: EPIDEMIC TO PANDEMIC

COVID-19 is a disease caused by the novel coronavirus, which was initially called 2019-nCoV, consequently termed as SARS-CoV-2 by the experts of the International Committee on Taxonomy of Viruses (ICTV) as it is exceptionally alike to the virus that caused the SARS outbreak in 2002 to 2003. World Health Organization already had declared COVID-19 as an international emergency as the disease is spre...

A. Majumdar *, N. Malviya and S. Alok

Department of Pharmaceutics, Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).1958-68

1958-1968

2350

937

2.

A REVIEW ON TAXANES: AN IMPORTANT GROUP OF ANTICANCER COMPOUND OBTAINED FROM TAXUS SP

Taxol is an important drug used for the treatment of various types of cancer. It is primarily obtained from Taxus brevifolia bark and has a long history of the developmental program of 50 years. It functions as a microtubule-stabilizing compound and inhibits mitosis of cancer cells, thereby providing a protective role in the treatment of cancers. In addition to it, taxol also interferes with a num...

D. Sinha

Department of Botany, Government General Degree College, Mohanpur, Paschim Medinipur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).1969-85

1969-1985

835

402

3.

DAPAGLIFLOZIN: AN ANTI-DIABETIC DRUG WITH CARDIOVASCULAR BENEFITS

Type 2 diabetes mellitus (T2DM) is a chronic disease, and most patients ultimately require two or more anti-hyperglycemic drugs along with lifestyle changes to achieve and maintain glycaemic control. Sodium-glucose co-transporter 2(SGLT2) inhibitors, such as Dapagliflozin, are the newest class of antidiabetic drugs approved for the treatment of T2DM. Dapagliflozin is a highly selective SGLT2 inhib...

S. Kalyan * and A. Parle

Department of Quality Assurance, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).1986-93

1986-1993

724

336

4.

JASMINUM GRANDIFLORUM LINN. – AN UPDATE REVIEW

Plants form the basis of human and animal life. Plants are better choice for medicinal applications when compared to synthetic chemicals and the nature has provided various types of medicinal plants. Jasminum grandiflorum Linn. (family Oleaceae) is a night bloomy flowering plant and is an important source of methyl jasmonates which find utility in plant defense, fruit ripening, plant growth senesc...

P. R. Bharathi, S. K. Sripathi * and A. N. Lakshmi

Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).1994-10

1994-2010

811

296

5.

FLUORIDE AND BRAIN: A REVIEW

The mammalian central nervous system is composed of the brain and spinal cord. The brain is protected by the blood-brain barrier (BBB) that allows selective traffic of substances into the brain. Fluoride is a highly toxic and reactive element. We get exposed to fluoride due to its common use in toothpaste, dental gels, non-stick pans, razor blades, etc. Fluoride also enters our food chain through ...

D. Ghosh and S. Ghosh *

Department of Physiology, Hooghly Mohsin College, Chinsura, Hooghly, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2011-17

2011-2017

681

251

6.

CHRONOPHARMACOLOGY: THE BIOLOGICAL CLOCK

Chronopharmacology is the science that is of different types in the pharmacological activities of different treatment over organic timings and endogenous balance. Chronotherapeutics is the science which increases the creativity and security of prescriptions by balancing their fixations during the 24 h synchronizing with regular routine determinants of disease. Chronopharmacokinetics again manages ...

S. Kapadia, V. Kanase *, S. Kadam, P. Gupta and V. Yadav

Department of Pharmacology, Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2018-26

2018-2026

360

104

7.

CHALCONE – PROMISING ENTITY FOR ANTICANCER ACTIVITY: AN OVERVIEW

Chalcones are naturally occurring compounds with a wide range of biological activities along with an anticancer activity through various mechanisms. It is also known as aromatic ketone, which creates a central core for different essential biologically active compounds. The literature on anticancer chalcones shows the use of various prolonged approaches like structural manipulation and replacement ...

A. A. Alman *, K. Daniel and S. G. Killedar

Department of Pharmacy, B. R. Nahata College of Pharmacy, Mandsaur University, Mandsaur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2027-41

2027-2041

279

108

Research Articles

 
Title
Views
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Cited
8.

THE ROLE OF AQUEOUS EXTRACT OF CITRUS SINENSIS PEEL IN CADMIUM MEDIATED HEPATOTOXICITY

Predisposing exposures to cadmium have been implicated in hepatotoxicity, hence the search for therapeutic interventions. Thirty Wistar rats were randomly grouped into six (1-6) with 5 rats each. Group 1 received only 5mg/kg body weight (b.wt) of Cadmium Chloride (CdCl2) intra-peritoneally. Group 2 received feed and water ad libitum. Groups 3 and 4 received CdCl2 followed by low and high dose (10m...

J. A. Nwafor *, E. N. Obikili, G. G. Akunna, G. E. Anyanwu and E. Esom

Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Alex Ekwueme Federal University Ndufu- Alike, Ikwo (AE-FUNAI), Ebonyi State, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.11(5).2042-51

2042-2051

675

326

9.

SOLUBILITY AND DISSOLUTION ENHANCEMENT OF POORLY AQUEOUS SOLUBLE DRUG GEFITINIB BY SELF EMULSIFYING DRUG DELIVERY SYSTEM

The present research work was aimed at the enhancement of solubility and dissolution rate of Gefitinib by Self Emulsifying Drug Delivery Systems (SEDDS). Gefitinib is a BCS class II drug with poor aqueous solubility (oral bioavailability 60%). The saturated solubility of Gefitinib in different oils, surfactants and co-surfactants were determined. The excipients were screened and selected showing m...

M. S. Reddy * and B. S. Vahini

Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2052-64

2052-2064

637

256

10.

PHYTOCHEMICAL ANALYSIS OF LEAVES OF XYLOSMA LONGIFOLIA CLOS.: A PLANT OF ETHNOMEDICINAL IMPORTANCE

The present study deals with the phytochemical study of leaves of Xylosma longifolia Clos. It belongs to the family Flacourtiaceae and is commonly known as ‘Long leaved xylosma’, whereas the plant is locally known as ‘Kataponial’ in Assam. Xylosma longifolia is an important ethnomedicinal plant used in the North-eastern region of India. The aim of the study is to investigate the bioactive ...

R. Bhattacharyya, J. S. Boruah, K. K. Medhi * and S. Borkataki

Department of Botany, Nowgong College, Nagaon, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2065-74

2065-2074

643

307

11.

PURIFICATION AND CHARACTERIZATION OF ANTI-HYPERGLYCEMIC BIOACTIVE MOLECULE FROM COSTUS PICTUS D. DON

Costus pictus D. Don., commonly known as the ‘Insulin plant’ is being used as a natural remedy to treat diabetes mellitus. The present study is focused to identify the chemical constituent responsible for the anti-diabetic activity of Costus pictus. The methanol extract was prepared from the fresh leaves of Costus pictus and washed with water to remove excess oxalic acid content present to get...

M. Benny *, B. Antony, A. P. A. Aravind, N. K. Gupta, B. Joseph and I. R. Benny

Research and Development Laboratory, Arjuna Natural Private Ltd., Erumathala, Aluva, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2075-81

2075-2081

579

231

12.

SPHERICAL CRYSTALLIZATION OF SITAGLIPTIN PHOSPHATE MONOHYDRATE FOR FORMULATION OF DIRECTLY COMPRESSIBLE TABLETS

Sitagliptin was invented in 2006 as a DPP-4 inhibitor. It is soluble in water to the extent of 0.03 mg/mL as thus suffers bioavailability problems. It was converted into phosphate monohydrate salt with solubility 50 mg/mL, which solved bioavailability problems. In this research, an attempt is made to convert it from its crystalline form into spherical crystals. Spherical crystals have better bulk ...

M. C. Singh * and R. R. Loharkar

Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2082-92

2082-2092

627

226

13.

DESIGN, OPTIMIZATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF VALSARTAN

The main aim of this work was to formulate and study mucoadhesive buccal tablets of valsartan using various suitable bioadhesive polymers such as CP 934 and Xanthan gum. Nine formulations of valsartan were prepared by the direct compression method. The prepared tablets were characterized by swelling studies, % matrix erosion, surface pH, bioadhesive properties, in-vitro drug dissolution and in-vit...

D. M. Shinkar, T. A. Shaikh * and R. B. Saudagar

Department of Pharmaceutics, Kalyani Charitable Trust's, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2093-03

2093-2103

262

87

14.

INJECTION SITE REACTION TO REPEATED INTRAVENOUS BOLUS INJECTION OF DICLOFENAC SODIUM IN TAIL VEIN OF WISTAR RAT

Diclofenac is the most popular and widely prescribed non-steroidal anti-inflammatory drug (NSAID). However, no preclinical data are available on repeated diclofenac IV bolus injection. In the present study, forty male Wistar rats were randomly divided in in total of four groups with 10 rats in each group. The control group received 0.9% sodium chloride injection. Marketed injectable Diclofenac Sod...

S. H. Raval *, R. S. Parmar, J. G. Patel, B. J. Patel, M. M. Pandya , H. D. Jani, S. P. Modh and P. I. Sindhi

Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Satsan, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2104-11

2104-2111

234

77

15.

PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF HEXANOLIC EXTRACT OF LANTANA CAMARA LINN.

Lantana camara Linn. is an important ethnomedicinal plant with several medicinal properties. It is widely used in the traditional medicinal system as carminative, anti-inflammatory, antipyretic and respiratory system infections. The present investigation was carried out to determine the qualitative analysis of phytochemical screening and the presence of bioactive compounds from the hexanolic extra...

M. Uparkar * and S. H. Ganatra

Department of Chemistry, Institute of Science, Civil Lines, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2112-17

2112-2117

217

111

16.

IMPROVEMENT IN BIOAVAILABILITY OF OXCARBAZEPINE USING SPHERICAL AGGLOMERATION

Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Oxcarbazepine spherical agglomerates were prepared by crystallo-co agglomeration technique. Acetone acted as a good solvent, aqueous solution of PEG 6000 served as a bad solvent, and dichloromethane was used as bridging liquid. The optimization was carried out using 23 factorial design, where the factors were...

G. S. Shinde and S. Mohite *

Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2118-26

2118-2126

209

81

17.

STABILITY INDICATING LC-ASSAY METHOD FOR METFORMIN HYDROCHLORIDE AND TENELIGLIPTIN HYDROBROMIDE FROM TABLET FORMULATIONS

A simple, rapid, accurate, robust, and specific HPLC method was developed for the assay of metformin hydrochloride and teneligliptin hydrobromide from the oral tablet formulations. Stability-indicating reverse-phase chromatographic method was developed on a RP C18 column (250 mm × 4.6 mm, 5µm) using a mixture of 20 mM ammonium acetate of pH 5.5 and methanol in the ratio 50:50 v/v as mobile phase...

A. Basu and J. Chakraborty *

CSIR Central Glass and Ceramics Research Institute, Jadavpur, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2127-34

2127-2134

214

86

18.

DEVELOPMENT AND IN-VITRO EVALUATION OF LIQUISOLID COMPACTS OF LORNOXICAM

The present study is undertaken with an aim to improve the dissolution profile and availability of a poorly soluble drug, Lornoxicam, through the development of liquisolid tablets. Liquisolid compacts were prepared by employing PEG 400, Avicel PH 112, and Aerosil 200 as solvent, carrier and coating materials, respectively. The flow properties of the drug improved significantly after formulating it...

S. S. Patil, A. S. Verma, H. Doddayya * and R. H. Udupi

Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2135-46

2135-2146

184

70

19.

FORMULATION AND EVALUATION OF LINAGLIPTIN BUCCAL ADHESIVE TABLETS FOR TYPE-II DIABETES

Last few decades, the remarkable advancement in the drug delivery system has been done; the oral route remains the importance and picks up the safest route of drug delivery. Regardless of striking advancements in the oral route medication, the current study focused on the formulation of a linagliptin buccal adhesive tablet. Formulated tablets are containing linagliptin as an active drug with a com...

V. R. Rao, P. Ravi * and K. E. Pravallika

Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2147-55

2147-2155

232

92

20.

IN-VITRO ANTICHOLINESTERASE ACTIVITY OF PHYLLANTHUS EMBLICA AND TAMARINDUS INDICA

Alzheimer’s disease (AD) is a major type of dementia. AD is associated with memory impairment and cognitive deficit. It is characterized by low levels of acetylcholine in the brain of AD patients. The inhibition of acetylcholinesterase (AChE) has been one of the most used strategies for the management of mild to moderate AD. In the present study, n-hexane, ethyl acetate, and hydroalcoholic leaf ...

M. Ponugoti *, D. Rispa, K. S. L. Sowjanya, K. Kiranmai, M. V. Kumar and N. M. N. Pavan

Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2156-60

2156-2160

195

81

21.

STABILITY INDICATING RP – HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE AND CHLORTHALIDONE IN BULK AND TABLET DOSAGE FORM

The RP-HPLC stability-indicating assay method has been developed and validated for the estimation of the amlodipine and chlorthalidone in bulk and combined dosage form. The method was optimized by using the mobile phase as a mixture of 0.1% formic acid: methanol: acetonitrile in the ratio of (50:5:45 v/v) at pH 3 was adjusted with orthophosphoric acid. The method was carried out on the Octadecylsi...

P. H. Sakpal * and A. R. Chabukswar

Department of Pharmaceutical Chemistry, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon (Kalewadi), Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2161-68

2161-2168

201

78

22.

ANTIHYPERGLYCEMIC POTENTIAL OF TEAK SEEDS IN ALLOXAN INDUCED DIABETIC RATS

Tectona grandis is famous as a valuable timber hold an extensive range of applications around the sphere. In addition to its enormous uses in the timber industry, all the parts are cherishing with extensive use in traditional medicine and possess significant pharmacological properties. In search of drugs for diabetes, the methanolic seed extract which is prepared by the Soxhlet apparatus, was used...

G. J. Rani and N. L. Bhavani *

Department of Botany, University College of Science Saifabad, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2169-72

2169-2172

175

90

23.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF EMPAGLIFLOZIN AND METFORMIN HYDRO-CHLORIDE IN COMBINED DOSAGE FORM

Two simple spectrophotometric methods have been developed for the simultaneous estimation of Empagliflozin and Metformin hydrochloride from the tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 224 nm (λmax of Empagliflozin) and 233nm (λmax of Metformin hydrochloride) using Methanol and Water as diluent. Method – II Absorption ...

P. Ashwini, J. Archana * and M. Sumakanth

RBVRR Women’s College of Pharmacy, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2173-80

2173-2180

203

84

24.

STANDARDIZATION AND QUALITY ASSESSMENT OF TRADITIONAL POLYHERBAL FORMULATION FOR THE TREATMENT OF HEMORRHOIDS (PILES)

Polyherbal formulations are a collection of therapeutic entities that are formulated and prepared on the basis of the healing properties of individual ingredients with respect to the condition of sickness. The main objectives of the present study were to evaluate the pharmacognostic parameters of a traditional polyherbal formulation for the treatment of hemorrhoids (piles). The pharmacognostic par...

P. Borah and M. Saikia *

Department of Herbal Science and Technology, ADP College, Nagaon, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2181-92

2181-2192

210

89

25.

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF DILTIAZEM HYDROCHLORIDE

Diltiazem HCl is a calcium ion channel inhibitor. The capacity to hinder the convergence of calcium ion present in of cardiac and vascular smooth muscle during membrane depolarization is accepted to be its therapeutic impact. It is broadly utilized in the treatment of a few kinds of cardiovascular disorders. For accomplishing better drug viability, unwavering quality success within the leading edg...

V. Ahmed *, S. Sharma and P. Bhatt

Vivek College of Technical Education, Bijnor, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2193-98

2193-2198

188

80

26.

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 6-(SUBSTITUTED BENZYLIDENE)-2-METHYLTHIAZOLO [2,3-b] OXAZOL-5(6H)-ONE AS POTENTIAL ANTICANCER AGENTS

Heterocyclic systems are a part of a large number of drugs and biologically relevant molecules. The chemistry and biological study of heterocyclic compounds have been an interesting field for a long time, and oxazole is one such moiety that has gained attention in recent times due to its increasing importance in the field of medicinal chemistry. Oxazole is a doubly unsaturated five-membered ring h...

D. D. Kini * and J. E. Mathews

Department of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2199-05

2199-2205

251

97

27.

FORMULATION AND IN-VITRO EVALUATION OF PLGA NANOPARTICLES OF GEFITINIB

The aim of this study was to formulate and evaluate nine formulations of Gefitinib loaded PLGA nanoparticles by homogenization followed by solvent evaporation technique by use of biodegradable and biocompatible polymer i.e. PLGA. The effect of different concentrations of polymer and stabilizer (PVA) on particle size, zeta potential, %EE and drug release was studied. PLGA was used in different conc...

M. Tajmal *, D. Goli and D. P. Venkatesh

Department of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2206-10

2206-2210

194

85

28.

DETERMINATION OF PHYTOCHEMICAL CONTENTS AND ANTIOXIDANT ACTIVITIES OF ETHANOL EXTRACT OF THE LEAVES OF SCURRULA PARASITICA L.

The phytochemical analysis of ethanol extract of Scurrula parasitica showed positive results for alkaloid, saponins, tannin, terpenoids, flavonoids, phenol, reducing sugar and phytosterols whereas glycoside is found to be absent. Total phenol and flavonoid contents were evaluated and found to be total phenolic compounds (101.9-379.1 µg/g tissue) and total flavonoids (72-174.1 µg/g tissue), respe...

J. Laldingngheta * and Lalnundanga and M. Vabeiryureilai

Department of Forestry, Mizoram University, Aizawl, Mizoram, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2211-16

2211-2216

194

86

29.

COMPARATIVE EVALUATION OF DICLOFENAC AND MELOXICAM AS TABLETS AND AS TRANSMUCOSAL MUCOADHESIVE PATCHES IN DENTAL PAIN REDUCTION

Aims and Objectives: To evaluate and compare diclofenac and meloxicam as tablets and as mucoadhesive patches in the control of odontogenic pain. Materials and Methods: 60 patients of either sex with acute dental pain were included in the study. Informed consent was obtained from each patient and they were randomly divided into 4 groups. Group A1 received meloxicam tablets, A2 meloxicam mucoadhesiv...

A. Chandrashekar *, R. G. Annigeri and J. Thimmasetty

Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2217-22

2217-2222

212

81

30.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF MIRABEGRON IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC

This current study describes developing the novel, precise, simple analytical method suitable for determination of Mirabegron (MIRA) in a pharmaceutical dosage form. Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method was utilized for method development and validation studies of MIRA. Chromatographic separation was carried out on Agilent technologies -1260 infinity system, eclip...

P. R. Sankar *, K. P. Kishore, B. Babji and M. S. Sulthana

Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2223-28

2223-2228

241

324

31.

UV SPECTROPHOTOMETRIC ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CLOMIPHENE CITRATE IN METHANOL

The present study describes simple, accurate, precise and cost effective UV-spectroscopic method for the estimation of clomiphene citrate in methanol as per ICH guidelines. The absorption maxima for clomiphene citrate in methanol was found to be 235nm and 294 nm. The drug follows linearity (linearity 1, linearity 2 & linearity 3) in the concentration range 3-40 μg/ml at 294 nm and 3-24 μg/ml...

A. Soni *, A. Chaudhary, S. Singla and S. Goyal

Department of Pharmaceutics, School of Pharmacy, Abhilashi University, Chail Chowk, Mandi, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2229-37

2229-2237

183

73

32.

PREDICTORS OF HEALTHCARE WORKERS’ KNOWLEDGE, ATTITUDES AND PRACTICES ON UNCOMPLICATED MALARIA IN PRIMARY HEALTHCARE SETTINGS OF PLATEAU STATE, NIGERIA

The quality of treatment and management of uncomplicated malaria depends on healthcare workers’ and patients’ characteristics, in addition to resource availability. This study assessed predictors of healthcare workers’ knowledge, attitudes, and practices (KAP) on uncomplicated malaria in primary healthcare (PHC) facilities in Plateau state, Nigeria. Secondary data of 289 healthcare workers i...

N. S. Jimam and N. E. Ismail *

Department of Clinical Pharmacy, Faculty of Pharmacy, MAHSA University, Selangor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.11(5).2238-47

2238-2247

181

72

33.

DEVELOPMENT OF FUROSEMIDE FLOATING MICROBALLOONS: IN-VITRO AND IN-VIVO EVALUATION

The present investigation deals with the development and evaluation of floating microballoons of furosemide to extend the gastric residence time (GRT) and prolong the drug release. In the present work, floating micro balloons of furosemide were formulated using eudragit RS 100, eudragit S 100, and HPMC K4M and ethylcellulose polymers by the solvent evaporation method. The prepared micro balloons w...

M. Pancheddula and Shayeda *

Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2248-61

2248-2261

191

61

34.

GC–MS ANALYSIS OF ANTIOXIDANT COMPOUNDS PRESENT IN DIFFERENT EXTRACTS OF AN ENDEMIC PLANT DILLENIA SCABRELLA (DILLENIACEAE) LEAVES AND BARKS

The study aimed to investigate and characterize the antioxidant compounds from the leaves and barks of Dillenia scabrella (Dilleniaceae) (D. scabrella), an indigenous plant in the Northeast. The air-dried leaves and barks were powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, namely, methanol, ethyl acetate + ethanol and water to o...

K. Momin and S. C. Thomas *

Department of Biosciences, Tapesia Campus, Assam Don Bosco University, Sonapur, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2262-73

2262-2273

208

76

35.

REGULATION OF RAS-INDUCED HYPHAL FORMATION BY HISTONE ACETYLASE GCN5 IN CANDIDA ALBICANS

Candida albicans is the leading cause of superficial and systemic fungal infections in human beings and is very common in people with a weakened immune system. It can grow either as budding yeast, a pseudohyphae form, or in a true hyphal form, and the ability to switch between these three forms is important for its pathogenicity. To date, an in-depth study on the relationship between histone modif...

L. Hauhnar * and H. Lalhruaitluanga

Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2274-81

2274-2281

157

74

36.

EVALUATION OF THE ANTI-DIABETIC ACTIVITY OF THE TRAN VIDHAI KUDINEER ON FRUCTOSE AND STREPTOZOTOCIN INDUCED DIABETIC RATS

Aim and Objectives: The present study was an attempt to investigate the effect of Thetran vidhai kudineer (TVK) on streptozotocin (STZ) induced diabetes in male Wistar rats. Methods: TVK, is a Siddha polyherbal formulation containing four ingredients includes Strynchnos potatorum, Terminalia chebula, Cassia auriculata, and Limonia acidissima. 6-8 week old 30 male Wistar albino rats fed with normal...

P. Elankani, G. D. Reddy *, N. Kabilan, P. Kumar, R. Ganesan, G. V. N. Kumar and D. Pitchaiah

Department of Pharmacology, Siddha Central Research Institute, Ministry of AYUSH, Government of India, Arumbakkam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2282-92

2282-2292

200

88

37.

DEVELOPMENT AND VALIDATION OF THE KINETIC-SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE DETERMINATION OF MEZLOCILLIN IN PURE SUBSTANCE AND MEDICAL PREPARATION

The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Mezlocillin (Mezl) with potassium caroate in alkaline medium is studied by the increase of forming product light absorbance at 290 nm. Baypen® – powder Mezl sodium monohydrate in flacons for preparation of solution for injections (Mezl 1.0 g). Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙K2SO4 (Oxone...

S. P. Karpova *, A. A. Krutskikh, O. O. Mozgova and O. V. Shovkova

Department of Physical and Colloid Chemistry, National University of Pharmacy, Pushkinska, Kharkiv, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.11(5).2293-98

2293-2298

173

69

38.

OPTIMIZATION OF AN ANTI-CANCER METABOLITE PRODUCTION BY PENICILLIUM RUBENS JGIPR9 VIA RESPONSE SURFACE METHODOLOGY

There are many pharmaceutically important compounds from Penicillium sp. that made the fungal genera one of the most important sources for the production of bioactive metabolites. As per the results of our previous study, a bioactive metabolite, P5, from Penicillium rubens JGIPR9 had highly promising cytotoxic and anti-cancer potentials. This prompted us to undertake the current study, so as to op...

P. Venkatachalam and V. K. Nadumane *

Department of Biotechnology, School of Sciences, JAIN (Deemed-to-be University), Jayanagar, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2299-09

2299-2309

162

70

39.

A STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR ANALYSIS OF VILDAGLIPTIN AS BULK DRUG AND FROM ITS PHARMACEUTICAL DOSAGE FORM

Vildagliptin chemically (S)-1-[N-(3-hydroxy-1- adamantyl) glycyl] pyrrolidine-2-carbonitrile, is a potent dipeptidyl peptidase IV (dip-IV) inhibitor, a drug for the treatment of diabetes. DPP-IV inhibitors represent a new class of oral antihyperglycemic agents to treat patients with type 2 diabetes. The Present work describes the development and validation of a new simple, accurate, precise and st...

K. R. Patil *, T. A. Deshmukh and V. R. Patil

SES Arunamai College of Pharmacy, Mamurabad, Jalgaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2310-16

2310-2316

182

75

40.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE DETERMINATION AND ESTIMATION OF ASENAPINE MALEATE IN BULK AND BUCCAL (EFFERVESCENT) DOSAGE FORM

Asenapine maleate is an atypical antipsychotic drug.  It was approved by USFDA in August 2009. It is an antagonist of 5-HT dopamine and α-adrenergic receptors and a high affinity for dopamine D2 and serotonin 5-HT2A receptors. It is indicated for the treatment of various psychotic conditions like schizophrenia and bipolar disorder in adults. So it leads to the requirement of accurate and precise...

K. Pansuriya *, P. Shelat and H. Patel

K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2317-23

2317-2323

164

67

41.

DEVELOPMENT AND VALIDATION FOR HIGH-PERFORMANCE MASS SPECTROMETRY METHOD FOR DETERMINATION OF BALOXAVIR MARBOXIL IN BIOLOGICAL MATRICES

The validated protein precipitation method was applied for the estimation of Baloxavir marboxil in human plasma with Oseltamivir as an internal standard (ISTD) by using HPLC-ESI-MS/MS. The chromatographic separation was achieved with 0.1% formic acid in combination with methanol (25:75 v/v) using the C18 column Ascentis Express (50 mm × 4.6 mm, 2.7 µm). The total analysis time was 3 min and the ...

B. Bhadru *, V. V. Rao and S. Vidyadhara

Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2324-31

2324-2331

251

81

42.

USHIRASAVA-PHYSICOCHEMICAL STANDARDIZATION AND QUANTITATIVE ESTIMATION OF SOME BIOACTIVES

Ushirasava is a commonly used ayurvedic formulation reported to be effective in Raktapitta (Bleeding disorders), Pandu (Anaemia), Kustha (Skin diseases), Prameha (Urinary disorders), Arsa (piles), Krmi (Worm infestation) and Sotha (Inflammatory diseases). It is a polyherbal hydroalcoholic product comprising of more than twenty-five ingredients. An exhaustive literature survey revealed that standar...

T. Khan * and H. Godbole

Department of Pharmaceutical Chemistry & Quality Assurance, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2332-41

2332-2341

175

73

43.

CHROMATOGRAPHIC DETERMINATION OF CURCUMIN IN THE PRESENCE OF ITS DEGRADATION PRODUCTS BY HPLC

A simple, selective, precise, and stability-indicating RP-HPLC method has been developed for the determination of Curcumin in bulk forms and solid dosage formulations. The HPLC separation was achieved on Waters Spherisorb ODS2 column (4.6mm × 250mm, 5µm particle size) using a mobile phase of methanol-water (77:33 v/v, pH 3) at a flow rate of 1ml/min and spectrophotometric detection at 419 nm. Th...

K. S. Sharma * and J. Sahoo

KIET Group of Institutions, Delhi-NCR, Ghaziabad affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2342-49

2342-2349

196

84

44.

QUANTIFICATION AND VALIDATION OF AMLODIPINE BESYLATE, OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE BY RP-HPLC IN MARKETED DOSAGE FORM

The endeavor of the present work is to develop a simple, economical, efficient, novel green analytical method for the estimation of Amlodipine besylate, Olmesartan medoxomil and Hydrochlorothiazide in pharmaceutical formulation. Quantification was carried out using an Inertsil CN-3.5 μm (4.6 ×250 mm) column, where the mobile phase consisting of 10 mm Phosphate buffer (pH 3.0) and Acetonitrile (4...

A. Patchala * and R. Nadendla

Department of Pharmaceutical Analysis, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2350-55

2350-2355

188

80

45.

FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLE GEL FOR TOPICAL DELIVERY OF CLOBETASOL PROPIONATE TO ENHANCE ITS PERMEATION USING SILK SERICINAS PERMEATION ENHANCER

The objective of this present work was to develop Solid Lipid Nanoparticle (SLN) gel for topical delivery of clobetasol propionate to enhance its permeation using silk sericin as a permeation enhancer. The proposed Clobetasol propionate gel loaded with solid lipid nanoparticle was prepared by solvent injection method. The effects of different strengths of lipid on the particle size, zeta potential...

A. A. Hajare *, P. D. Velapure, P. N. Rathod, K. S. Patil and S. S. Chopade

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2356-65

2356-2365

215

105

46.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION STUDIES FOR THE ESTIMATION OF ASPIRIN, CLOPIDOGREL BISULPHATE AND ROSUVASTATIN CALCIUM IN FIXED DOSE COMBINATION CAPSULES

The present project was conducted with the objective of developing and validating a RP-HPLC method for the simultaneous estimation of aspirin, clopidogrel bisulphate, and rosuvastatin calcium in fixed-dose combination capsule. The chromatographic separation was carried out on Agilent 1260 series using Waters C18 (250 × 4.6 mm, 5 μ) column as the stationary phase and acetonitrile (ACN): phosphate...

R. Singh and T. Khan *

SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2366-73

2366-2373

201

89

47.

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME COMPOUNDS OF 1,8-NAPHTHYRIDINE-3-CARBOXAMIDE

Various nitrogenous heterocyclic compounds like 1, 8-naphthyridine-3-carboxamide are synthesized and studied for their wide range of biological activity. Versatile activity of this scaffold will increase interest from innovator on significance of their antibacterial activity and will influence their role in drug discovery. Synthesis and Antibacterial evaluation of ten derivatives of 1-ethyl-4-oxo-...

M. R. Suryawanshi * and D. D. Dupade

Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Earandwane, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2374-79

2374-2379

161

122

48.

ANTI-LIPID PEROXIDATION ACTIVITY OF ALLMANIA NODIFLORA (L.) R. BR.: A TRADITIONAL LEAFY VEGETABLE

Allmania nodiflora (L.) R. Br. is a diffuse herb, belongs to family Amaranthaceae. Fresh leaves used as a green leafy vegetable, which is rich in vitamins and iron. The present aim of this work is to evaluate the phytochemical composition and antioxidant activity of ethanol and water extracts of A. nodiflora leaves. The results on the phytochemical composition of the water and ethanol extracts of ...

A. L. Devi, P. V. M. Raddy and K. V. Ratnam *

Department of Botany, Rayalaseema University, Kurnool, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2380-84

2380-2384

160

75

49.

FORMULATION OPTIMIZATION OF IMMEDIATE RELEASE BILAYER TABLETS OF TELMISARTAN AND HYDROCHLOROTHIAZIDE

The aim of the current investigation was to develop bilayered immediate-release tablets of Telmisartan (TEL) and Hydrochlorothiazide (HCTZ) for the treatment of hypertension. In contrast to monotherapy, the dual drug therapy of TEL (an angiotensin II receptor blocker) and HCTZ (diuretic) is connoted to have a cumulative antihypertensive effect. Additionally, it offers ameliorative patient adherenc...

N. Sharma *, S. Pahuja and P. Sarup

Swami Vivekanand College of Pharmacy, Banur, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2385-95

2385-2395

236

91

50.

EVALUATION OF PHYTOCONSTITUENTS, FT-IR ANALYSIS, TOTAL PHENOLIC, FLAVONOID CONTENTS, IN-VITRO ANTIBACTERIAL AND ANTIOXIDANT STUDIES OF ETHANOLIC ROOT EXTRACT OF MILLETTIA PINNATA

This research work presents the phytochemical and FTIR analysis, total phenolic, and flavonoid quantification, and evaluation of in-vitro antibacterial and antioxidant activity of ethanolic root extract of Millettia pinnata. Ethanolic root extract was subjected to the phytochemical and FTIR spectrum analysis. Total phenolic and flavonoid contents were quantitatively determined by Colorimeter. The ...

R. K. Banoth *, S. Shaik, T. Dumpala and P. Yadav

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2396-02

2396-2402

210

85

51.

IMPACT OF PHARMACISTS’ HEALTH EDUCATIONAL INTERVENTION ON ANEMIA IN PREGNANCY IN RURAL SETTINGS IN KANO, NIGERIA

The worsening trend of anemia in pregnancy continues to be a cause for concern in many developing countries. There is a need for synergy involving all health care professionals in order to reverse this alarming trend. The objective of this study was to assess the impact of pharmacists initiated health education intervention on anemia in pregnancy in the rural setting, in Kano, Nigeria. A total of...

D. U. Adje *, M. I. Umar, M. A. Gadanya and R. A. Rufai

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, Delta State University, Abraka, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.11(5).2403-10

2403-2410

172

75

52.

ETHANOLIC LEAF EXTRACT OF PREMNA TOMENTOSA AMELIORATES ALCOHOL INDUCED HEPATOTOXICITY IN ALBINO RATS

Alcoholic liver disease (ALD) comprises a wide variety of damage, starting from steatosis to liver cancer. ALD results from a multifactorial interaction between behavioral, ecological and hereditary factors. This study aimed to evaluate the hepatoprotective effect of ethanolic extract of Premna tomentosa (EEPT) on ethanolic toxicity liver. The characterization of EEPT extract was performed using s...

T. Gomathipriyadharsini *, M. Kavimani, S. Sathiyanarayanamurthy and K. Prabhu

Bharath University, Department of Anatomy, Vivekananda Dental College for Women, Thiruchengode, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2411-14

2411-2414

166

77

53.

GC-MS ANALYSIS AND IN-VITRO ANTI-DIABETIC ACTIVITY OF BIOACTIVE FRACTIONS OF FERONIA ELEPHANTUM FRUIT

The present study was carried out to characterize the bioactive phytoconstituents from the fractions of F. elephantum fruit and to evaluate their in-vitro anti-diabetic activity. Column chromatography of methanol extract of F. elephantum fruit yielded  Hexane: Ethyl acetate (1:1 v/v) fraction (HEFE), Ethyl acetate fraction (EFE) and Ethyl acetate: Methanol (1:1 v/v) fraction (EMFE), which were su...

G. J. Reddy *, K. B. Reddy, G. V. S. Reddy

Department of Pharmacology, SVU College of Pharmaceutical Sciences, S. V. University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2415-24

2415-2424

205

87

54.

BIOLOGICAL EVALUATION, SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL MANNICH BASES OF PYRAZOLINE DERIVATIVES

In the present investigation, some novel Mannich Bases of Pyrazoline derivatives(7a-g) is synthesized by treating various substituted acetophenones (1a-g) with 6-methaoxy-1-napthaldehyde (2) in alcoholic sodium hydroxide to obtained intermediate Chalcones (3a-g), which was further treated with isonicotinohydrazide (4) to get (3-(4-substituted phenyl)-5-(6-methoxy naphthalen-1-yl)-4, 5-dihydro- 1H-...

S. B. Jadhav * and P. K. Vibhute

Department of Chemistry, Balbhim Arts, Science & Commerce College, Beed, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2425-30

2425-2430

166

83

55.

DESIGN EXPERT SOFTWARE ASSISTED DEVELOPMENT AND EVALUATION OF CEFPODOXIME PROXETIL MATRIX TABLET

Cefpodoxime Proxetil is third generation, broad-spectrum Cephalosporin Antibiotic & it has an oral bioavailability of only 50% and biological half life 2 h so to improve it’s bioavailability sustain release matrix formulation was designed. Sustained release matrix tablets of Cefpodoxime Proxetil prepared by direct compression method based on combination of natural Acacia gum & Karaya gum...

N. S. Siraj *, M. S. Ismail, G. J. Khan, S. H. M. Athar and R. L. Jadhav

Department of Pharmaceutics, Ali Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2431-43

2431-2443

230

87

56.

A STUDY ON PREVALENCE OF MEDICATION ERRORS IN A MULTISPECIALTY HOSPITAL

Background: Medication errors (MEs) are the potential to cause adverse clinical outcomes. The incidence of MEs is hopefully controlled with patient-centric pharmaceutical services. The present study evaluated the incidence of MEs in various departments in a multispecialty hospital in India. Methods: This prospective observational was analyzed 100 prescriptions included 749 drugs from general medic...

M. Bothiraj *, M. Alagusundaram and K. B. C. Sekhar

JNTUA, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2444-47

2444-2447

187

79

57.

EVALUATION OF IN-VITRO ANTI-BACTERIAL AND CYTOTOXIC ACTIVITY OF LEEA MACROPHYLLA

Studies have confirmed the medicinal potential of the Leea macrophylla mentioned in traditional medicine. While the effects of the Leea macrophylla extract on some bacteria and Brine shrimp lethality using their different concentrations has not been previously explored. The present study shows that the standardized aqueous and ethanolic extract of Leea macrophylla exhibited antibacterial and cytot...

P. M. Somade *, A. R. Chopade, P. A. Patil and S. B. Kengar

Department of Physiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2448-50

2448-2450

155

73

58.

PREVALENCE OF EXTENDED-SPECTRUM β-LACTAMASE-PRODUCING SALMONELLA ON GREEN LEAFY VEGETABLES FROM A STREET VENDOR

Consumption of fresh leafy vegetables by a street vendor cause salmonellosis is a major public health problem worldwide. The aim of the study to investigate total microbial count and the occurrence of ESBL producer and antimicrobial resistance pattern of Salmonella from fresh leafy greens. In this sample Salmonella spp. Population ranged from 40.33 to 35.33 × 102 CFU/g of fresh samples. The highe...

B. Manivel * and P. Angalaparameswari

Department of Chemistry and Biosciences, SASTRA Deemed to be University, SRC, Kumbakonam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2451-61

2451-2461

291

66

59.

NEUROBIOLOGICAL EVALUATION OF DERIVATIVES OF SUBSTITUTED PHENYL-ETHYLAMINE AND ETHYLAMINE

Cognitive functions are mainly categorized into memory, attention, creativity, and intelligence. Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind. Phenylethylamine is an organic compound which is also known as β-phenylethylamine (β-PEA) and is the name of a class of chemicals which shows psychoactive and stimulant effects. It is a trace amine ...

N. Kaur * and J. S. Dua

LBR College of Pharmacy, Golpura, Panchkula, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2462-69

2462-2469

164

78

60.

DEVELOPMENT OF RP-HPLC METHOD FOR SIMULTANEOUS EVALUATION OF UNIFORMITY OF DOSAGE UNITS FROM ASPIRIN AND DIPYRIDAMOLE EXTENDED-RELEASE CAPSULES

The aim of the present study is to develop a stability-indicating reverse-phase high-performance liquid chromatography method for the simultaneous estimation of Aspirin and Dipyridamole in combined extended-release dosage form 25/200mg, using a single unit of the capsule. Materials and Methods: Chromatographic separation was achieved with Agilent's high-performance liquid chromatography and X brid...

D. Thamizhanban *, G. T. Rani and K. Krishnasamy

Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2470-81

2470-2481

176

73

61.

INVESTIGATION OF SOLVATION DYNAMICS AND HYDRATION PATTERN OF SIALIC ACID BY AB INITIO AND DFT METHOD

Sialic acid is the active site of neuraminidase virus and it proliferates the infection in the human body by cleaving it from the neuraminidase viral protein. The buried water molecule influences the binding between the ligand and the receptor. Hence, solvation dynamics and hydration pattern of sialic acid needs to be investigated to design the antiviral inhibitor. Cluster continuum solvation anal...

K. Chandrasekaran

Department of Chemistry, Sri Krishna College of Engineering and Technology, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2482-88

2482-2488

175

67

62.

STATISTICAL OPTIMIZATION OF ORALLY DISINTEGRATING TABLETS OF MEMANTINE HYDROCHLORIDE

Objective: The present work deals with the statistical optimization of memantine hydrochloride orally disintegrating tablets by the design of experimentation. The study was aimed at the development of a stable and robust formulation for the well-being of society for the treatment of Alzheimer’s disease, which is the most common form of dementia. Methods: Binder (X1), disintegrant (X2), and dilue...

I. S. Ghogari * and P. S. Jain

Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2489-97

2489-2497

187

85

63.

MOLECULAR DOCKING AND IN-SILICO ADME STUDIES OF NOVEL DERIVATIVE OF ERLOTINIB IN GLIOMA

Glioblastoma (GBM), with restricted therapy alternatives, is a catastrophic primary brain tumor. The receptor of the epidermal growth factor receptor (EGFR) in glioblastomas is recurrently enhanced, over articulated, or mutated, but up to 20 percent of GBM patients find it to be responded to kinase inhibition of EGFR. Several inhibitors of EGFR tyrosine kinase (TKI) failed clinically, due in part ...

D. Tripathi and S. Imran *

Department of Biotechnology, Faculty of Engineering and Technology, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2498-03

2498-2503

195

87

64.

GC-MS ANALYSIS OF BIOACTIVE COMPOUNDS FROM ETHANOLIC EXTRACT OF WHOLE PLANT OF MOLLUGO OPPOSITIFOLIA L. AND THEIR PHARMACOLOGICAL ACTIVITIES

Ethanolic extract of the whole plant of Mollugo oppositifolia L. of Molluginaceae has been analyzed by using GC-MS for Bioactive compounds and for their pharmacological activities. GC-MS showed 32 compounds and is confirmed with the help of the database of NIST. Out of these, seven major Bioactive compounds are identified based on their retention time and peak area in GC-MS chromatogram. Among the...

A. G. Nagannawar * and M. Jayaraj

P. G. Department of Botany, Karnatak University, Dharwad, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2504-09

2504-2509

186

86