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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 4 (2013) - Issue 3, March

Review Articles

 
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1.

AN OVERVIEW OF PHARMACOTHERAPY OF OBESITY: AN UPDATE

Obesity is a chronic disease and a major health problem which require long term treatment in developed and affluent society of developing countries. Pharmacotherapies for obesity have to be given for a long duration with lifestyle modifications. Anti-obesity drugs acts through various targets in the body which reduce the food intake, decrease absorption and increase metabolism. Many drugs were app...

A. K. Misra and S. K. Verma

Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sewagram– 442102, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).881-90

881-890

2030

783

2.

TINOSPORA CORDIFOLIA: ETHNOBOTANY, PHYTOPHARMACOLOGY AND PHYTOCHEMISTRY ASPECTS

Tinospora cordifolia (Thunb.) Miers, (Guduchi) is an evergreen perennial climber. This deciduous and dioecious plant belongs to the family Menispermaceae. It is a plant of significant medicinal importance in the Indian system and designated as Rasayana. Its efficacy has been also recognized by the modern system of medicine. The whole plant is used medicinally however; the stem is approved for us...

Namrta Choudhary*, M.B. Siddiqui , Shazia Azmat and Sayyada Khatoon

Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).891-99

891-899

2924

1776

3.

ATHEROSCLEROTIC RISK AMONG EPILEPTIC PATIENTS TAKING CARBAMAZEPINE, PHENYTOIN TREATMENT: BRIEF REVIEW

Epilepsy is a common chronic neurological disorder that requires long-term or sometimes lifetime therapy. Anticonvulsant drugs are used in large quantities during long-term antiepileptic therapy and the treatment may be associated with various metabolic abnormalities in connective tissues, endocrine system and the liver. Recent evidence indicates that prolonged use of antiepileptic drugs (AEDs) pa...

S. S. Khot*, Md. Hanif Shaikh and Lalitkumar Gupta

Vadu Rural Health Program, K.E.M. Hospital Research Centre, Sardar Moodliar Rd, Rasta Peth, Pune 411011, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).900-06

900-906

1965

567

4.

NAIL AS A PROMISING DRUG DELIVERY SYSTEM FOR CONTROLLED RELEASE

The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). Current research on nail permeation that focuses on altering the nail plate barrier by means of chemical treatments, penetration enhancers as well ...

G. Sai Krishna*, P. Prem Kumar, K. Bala Murugan

SIMS College of Pharmacy, Mangaldas Nagar, Guntur-522001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).907-15

907-915

2504

726

5.

MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM: A REVIEW

As an alternative to injection pharmaceutical researcher and scientist are trying to explore transdermal and transmucosal route over the last few years. To overcome the deficiency associated with the other route of administration buccal region of oral cavity is an alternative target for the administration of choice of drug. The disadvantages relative with the oral drug delivery is the extensive pr...

Jasvir Singh* and Pawan Deep

School of Pharmaceutical Sciences, Shoolini University, Solan- 173 212, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).916-27

916-927

3120

841

6.

SOLID LIPID NANOPARTICLES; A REVIEW

Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could use for drug t...

Mudavath Hanumanaik*, Sandeep Kumar Patel and K. Ramya Sree

Department of Pharmaceutics, KLE’S College of Pharmacy, Vidyanagar, Hubli-580031, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).928-40

928-940

2975

640

7.

CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW. PART IV: NON-ALKALOIDAL CONSTITUENTS

Crinum is an important and fascinating genus of the large and equally captivating Amaryllidaceae family. Owing to the valuable biological effects and therapeutic potentials of its chemical constituents, many Crinum species have a worldwide folkloric reputation. Additionally, Crinum species have been subjected to extensive chemical, cytological and pharmacological investigations. The present part o...

John Refaat *, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).941-48

941-948

1689

627

8.

PHYTOSOMES: A NOVEL DRUG DELIVERY FOR HERBAL EXTRACTS

Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. Our country has a vast knowledge base of Ayurveda whose potential is only being realized in the recent years.The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compound. Severe limitation exist...

M. Sravanthi* and J. Shiva Krishna

Department of Pharmaceutics, Malla Reddy Institute of Pharmaceutical sciences, Kompally, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).949-59

949-959

5504

1455

9.

PULSATILE DRUG DELIVERY SYSTEMS: RECENT TECHNOLOGY

Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug re...

Abdul Sayeed*, Md. M. Hamed , Mohd. Rafiq and Nahid Ali

Assistant Professor, Mesco College of pharmacy Hyderabad

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).960-69

960-969

2684

757

10.

NOVEL DRUG DELIVERY SYSTEMS: AN OVERVIEW

Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety and efficacy. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. An appropriately designed Novel Drug Delivery System can be a major advance for solving the problems related towards the rel...

R.R. Bhagwat* and I.S. Vaidhya

Department of Quality Assurance, Dr. L.H. Hiranandani College of Pharmacy, C.H.M. College Campus, Opp. Rly Stn., Ulhasnagar- 421003, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).970-82

970-982

48286

3874

Research Articles

 
Title
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11.

DETECTION OF ETHYLENE FOR IN VIRO EVALUATION OF THE UV PHOTOPROTECTION

In this study, the antioxidant capacity during UV exposure has been investigated by using a laser-based trace gas detector for the detection of gaseous ethylene as an indicator for lipid peroxidation. Biocream was used as a control and ascorbic acid, butylated hydroxytoluene, phloroglucinol and hydroquinone were added as antioxidants in a mixing concentration of 2.5% (w/w). The experimental result...

I. E. Santosa , A.N.I. Harnita , S. Martono , Sudarsono , S. Widyarini and F.J.M. Harren*

Life Science Trace Gas Facility, Molecular and Laser Physics, Radboud University, Nijmegen, the Netherlands

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).983-87

983-987

3535

451

12.

COMMUNITY PHARMACISTS’ INVOLVEMENT IN THE ORDERING AND INTERPRETATION OF LABORATORY TESTS

The focus of this exploratory study was to determine if community pharmacists order laboratory tests, why they order the tests, type of tests they order and what they do with the outcome of such tests. Self-administered pre-tested 34-item semi-structured questionnaires were used to carry out this study among superintendent pharmacists’ of registered pharmacy premises in two south-western states ...

Showande

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).988-96

988-996

1753

397

13.

COSMETICS UTILIZATION PATTERN AND RELATED ADVERSE REACTIONS AMONG FEMALE UNIVERSITY STUDENTS

Background: Cosmetics are articles applied to the human body for cleansing, beautifying, promoting attractiveness or altering appearance. In the last few years, the consumption of cosmetics has touched new heights and the curve is shooting upwards. Along with this, cosmetics are causing alarming adverse reactions to consumers and hence studying their utilization pattern and impact besides beautify...

H. Dibaba, D. Yadesa, B. Legesse *, Z. Shewamene and B. W. Gerima

Pharmacy Department, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).997-04

997-1004

2880

601

14.

DEVELOPMENT AND IN VITRO EVALUATION OF ONCE DAILY CARBAMAZEPINE MATRIX TABLET FROM HYDROPHILIC POLYMERS

The purpose of study was to develop and characterize once daily extended release matrix tablets of Carbamazepine (CBZ), an antiepileptic drug. Tablets were prepared by wet granulation method. Methocel K15M CR and Methocel K100LV CR polymers were used as rate retarding agents in fourteen formulations.  The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compre...

Sharifa Sultana , Harun-Or-Rashid , Shimul Halder*, A. K. L. Kabir and A.S.S. Rouf

Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1005-12

1005-1012

1544

635

15.

FORMULATION AND EVALUATION OF BSA LOADED PLGA MICROPARTICLES

Protein drug delivery has emerged to be an important area of research in the field of novel drug delivery technology. The objective of the study was to prepare poly (D, L-lactide-co-glycolide) (PLGA) microspheres containing bovine serum albumin (BSA) as a  model  drug  and  to  evaluate  the  various  physicochemical  characteristics  of  the formulations, namely morphology, particle si...

Santosh Voruganti*, J. Surya Chandra Padman

Department of Pharmaceutics, Mother Teresa College of Pharmacy, Ghatkesar, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1013-21

1013-1021

2078

597

16.

INFLUENCE OF VERAPAMIL ON PHARMACOKINETICS OF PIOGLITAZONE IN NORMAL AND DIABETIC RATS

The study was undertaken to find out the pharmacokinetic drug interaction of verapamil on pioglitazone in normal and alloxan induced diabetic rats following single and multiple dose treatment. Human oral therapeutic doses of pioglitazone and verapamil were extrapolated to rats based on their body surface area. The serum pioglitazone concentrations were estimated by a sensitive reverse phase – hi...

Ravikanth Chintala , Chaitanya Gadiko , Bhikku Angoth and Narsimha Reddy Yellu*

Associate Professor, Pharmacology & Clinical Pharmacology Division, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India – 506009

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1022-26

1022-1026

1465

524

17.

ASSESSMENT OF KNOWLEDGE, ATTITUDE, AND PRACTICE TOWARDS EMERGENCY CONTRACEPTIVES AMONG FEMALE COLLEGE STUDENTS AT MEKELLE TOWN, TIGRAY REGION, ETHIOPIA: A CROSS SECTIONAL STUDY

Background: Death related to unintended pregnancy associated events is a series public health concern in Ethiopia. This is very common in young adolescents for whom life is full of adventure and temptation with very little knowledge about the consequences of their reckless activities. Emergency contraceptives are the only method that can be used within short time after sexual intercourse, offering...

Haftom Gebrehiwot*, Berhane Gebrekidan, Haftu Berhe and Kalayou Kidanu

Department of Midwifery & Nursing, Mekelle University & AAU, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1027-38

1027-1038

4807

1849

18.

DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF RAMIPRIL AND EVALUATION OF POLYMER EFFECT ON IN-VITRO RELEASE PATTERN

The objective of the current study was to design an oral sustained release matrix tablet of Ramipril and to evaluate the effect of polymer on release pattern of the drug. Tablets were prepared by direct compression method using Methocel (Hydroxy Propyl Methyl Cellulose) K100MCR and Methocel (Hydroxy Propyl Methyl Cellulose) K4MCR, as matrix forming polymer. Dissolution studies were carried out in ...

Monsur Ahmed, Sayed Koushik Ahamed, Syed Masudur Rahman Dewan, Md. Mizanur Rahman Moghal*

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1039-45

1039-1045

2274

428

19.

EFFECT OF SOLVENT EXTRACTION SYSTEM ON THE ANTIOXIDANT ACTIVITY OF SOME SELECTED WILD LEAFY VEGETABLES OF MEGHALAYA STATE IN INDIA

The antioxidant activities of five wild leafy vegetables e.g. Allium porrum, Carpesium cernuum, Tricyrtis pilosa, Spilanthes acmella, and Leea sambucina collected from Meghalaya state in India were determined  by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power ability, estimation of total phenolic content, flavonoid content and flavonol content.. The result...

Tapan Seal*, Basundhara Pillai and Kaushik Chaudhuri

Botanical Survey of India, A.J.C. Bose Indian Botanic Garden, Shibpur, Howrah, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1046-51

1046-1051

1443

461

20.

DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR THE ESTIMATION OF HYDROCHLOROTHIAZIDE IN TABLET DOSAGE FORMS

An accurate, precise and reproducible high performance liquid chromatographic method was developed for quantitative estimation of hydrochlorothiazide in tablet dosage forms. Chromatographic separation of the drug was achieved on a Kromasil C18 column (150 x 4.6 mm; 5µ) using a mobile phase consisting of phosphate buffer (pH 2.5) and acetonitrile (50:50 v/v) at a flow rate of 0.6 mL/min. The drug ...

V. Vijayasree , C. Pallavan and J.V.L.N. Seshagiri Rao*

Yalamarty College of Pharmacy, Tarluwada, Visakhapatnam- 530052, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1052-55

1052-1055

1659

568

21.

EVALUATION OF CARDIOPROTECTIVE EFFECTS OF CAMELLIA SINENSIS ON ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION

Background: Black tea is rich in polyphenols which are antioxidants. The most abundant polyphenolic compounds are flavonols and catechins. Black tea antioxidants showed protective actions against chronic diseases like cardiovascular diseases due to their antioxidant action. Objective: The present study was conducted to evaluate the cardioprotective effects of Camellia sinensis on isoproterenol ...

Razieh Afshar Moghaddam , Mohd. Akhtar , Atefeh Afshar Moghaddam and Abul Kalam Najmi*

Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1056-63

1056-1063

1615

604

22.

BIODIVERSITY OF THE ENDOPHYTIC FUNGI ISOLATED FROM MORINGA OLEIFERA OF YERCAUD HILLS

Endophytic fungi residing inside the medicinal plants are of gaining importance for their bioactive compounds. This present study is undertaken to isolate and identify the potential endophytic fungi from Moringa oleifera, a traditional medicinal plant. A total of 24 segments each 12 from leaf and stem were collected, surface sterilized and was inoculated on to Sabouraud Dextrose Agar (SDA) plates....

R. Dhanalakshmi, S. Umamaheswari, P. Sugandhi and D. Arvind Prasanth*

Medical Microbiology Unit, Department of Microbiology, Periyar University, Salem-636011, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1064-68

1064-1068

2375

909

23.

COMPARATIVE STUDY OF RADICAL SCAVENGING ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF FRESH AND DRY RHIZOMES OF CURCUMA ZEDOARIA

Oxygen is an element obligatory for life. Biological combustion produces harmful intermediates called free radicals. Free radicals are continuously produced by the body’s aerobic life and our metabolism. Antioxidants are the substances, which act against oxidative compounds. Under normal conditions the body’s antioxidants convert ROS to prevent the over production of free radicals. Recently, n...

S. Sumathi*, G.T. Iswariya, B. Sivaprabha, B. Dharani, P. Radha, and P.R. Padma

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher education for Women University, Coimbatore – 641 043, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1069-73

1069-1073

1739

801

24.

COMPARATIVE PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDY OF LEAVES OF DIFFERENT SPECIES OF MIMUSOPS

Background: Two primary species of Mimusops are Mimusops elengi and Mimusops hexandra. Leaves of both species are traditionally used in several ailments. However, it is difficult to distinguish the leaves of the species. Objectives: The present investigation deals with the comparative pharmacognostical study of the leaves of the two species and establishment of its quality parameters. Method...

S.A. Madhak, J.D. Savsani and D.J. Pandya*

RK College of Pharmacy, Rajkot, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1074-78

1074-1078

1492

450

25.

STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF CANDESARTAN IN PHARMACEUTICAL DOSAGES FORM

Candesartan was degraded together under different stress test conditions prescribed by International Conference on Harmonization. The samples so generated were used to develop a stability-indicating high performance liquid chromatographic (HPLC) method for the candesartan. The drug was well separated from degradation products using a reversed-phase (C-18) column and a mobile phase comprising of Ac...

Sachin Bhagwate*, N. J. Gaikwad and Pawan Tarte

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Nagpur 440 033, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1079-85

1079-1085

1951

500

26.

ASSESSMENTS OF ADHERENCE TO HYPERTENSION MANAGEMENTS AND ITS INFLUENCING FACTORS AMONG HYPERTENSIVE PATIENTS ATTENDING BLACK LION HOSPITAL CHRONIC FOLLOW UP UNIT, ADDIS ABABA, ETHIOPIA-A CROSS-SECTIONAL STUDY

Background: In Ethiopia 10.6% and Addis Ababa, 30% of the population has been estimated to have hypertension. Adherence to medication therapy and lifestyle change is an aspect of patients’ care that is often overlooked and should be evaluated as a crucial part of cardiovascular management. Objective: The aim is to assess adherence and influencing factors of adherence to hypertensive managemen...

Habtamu Abera Hareri*, Mesfin Abebe and Tadese Asefaw

Department of Nursing, College of Health sciences, Debre Markos University, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1086-95

1086-1095

2085

582

27.

SPECTROPHOTOMETRIC DETERMINATION OF Co(II) AS A COMPLEX WITH 1, 2 – PROPANEDIONE, 1- PHENYL – 1 – ( 2 – HYDROXYL – 5 – BROMO – BENZILIDINEAZINE)-2-OXIME [PDPHBBAO]

The reagent was synthesized and characterization was carried out by FTIR, NMR, elemental analysis as well as Mass spectrometry. This reagent was then applied for the development of the analytical method for the extractive spectrophotometric determination of Cobalt (II). Cobalt metal forms yellow coloured complex, which can be extracted in chloroform at pH 9.0 having absorption maxima at 430 nm. Be...

Rama S. Lokhande*, Poonam P. Shevde and Sushama M. Lele

Department of Chemistry, University of Mumbai, Vidyanagri, Santacruz (E), Mumbai- 400 098, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1096-98

1096-1098

1324

501

28.

COMPUTATIONAL APPROACH FOR DESIGNING AND DEVELOPMENT OF POTENT DRUG INHIBITOR FOR APP GENE IN ALZHEIMER’S DISEASE

Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, reasoning, planning, language, and perception, and eventually even the ability to carry out the simplest tasks. Many scientists believe that Alzheimer's disease results from an increase in the production or accumulation of a specific protein (beta-amyloid protein) in the brain ...

Santosh Kumar Behera*, Ritesh Kumar Behera and Manas Ranjan Barik

Department of Chemistry, University of Mumbai, Vidyanagri, Santacruz (E), Mumbai- 400 098, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1099-04

1099-1104

1362

417

29.

INVESTIGATION OF ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY OF CURCUMA LONGA

Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plantused as a food additive. It has been reported that rhizome of this plant have antibacterial, antifungal, anti-inflammatory, antioxidant and antitumor property. Methanol extract of Rhizome of Curcuma longa was investigated here to see the antimicrobial actions and anti-inflammatory effect.  During the extraction process a purified...

Mohammad Basir Khan, Md. Atai Rabby , Md Hasmat Ullah and Chowdhury Faiz Hossain

Department of Biochemistry and Molecular Biology, Jahangirnagar University, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1105-09

1105-1109

1901

499

30.

PHYLOGENETICAL CHARACTERIZATION OF CYANOBACTERIA FROM PADDY FIELD OF CHHATTISGARH (PART I)

With respect to Chhattisgarh, rice is the principal crop of the state. India Covers 66% of cultivable land and mostly grown under kharif cropping season. To increase sustained productivity without decreasing soil quality, algal bio fertilizers are used widely now days in the state. Use of local isolates as algal inoculants is being stressed due to their competitiveness in the field for establishme...

Pankaj Bajpai

School of Biotechnology, Guru Ghasidas University, Bilaspur, Chhattisgarh, 495009, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1110-15

1110-1115

1684

498

31.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF RISPERIDONE BY MBTH

A simple and sensitive visible spectrophotometric method is described for the assay of risperidone (RSP) in pure and solid dosage forms. The method involves oxidative coupling of risperidone with MBTH in presence of ferric chloride dissolved in HCl and apple green chromogen is formed and exhibits absorption maxima at 595.8nm. Regression analysis of Beer-Lambert plots showed good correlation in the...

S. Archana*, Y. Naga Prasanna, P. Pavitra, D. Santhi Krupa, M. Hema Sri

Research Lab., Aditya Institute of Pharmaceutical Sciences & Research, ADB Road, surampalem, Kakinada, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1116-19

1116-1119

1735

724

32.

ANTI-ULCER EFFECT ON THE ETHANOL EXTRACT OF THE BARK & ROOT OF FICUS RELIGOISA LINN. IN DIFFERENT EXPERIMENTAL ULCER MODELS IN RATS

Ficus religiosa L (Moraceae) is widely distributed in northern part of India has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Ficus religiosa L was used for investigation of antiulcer activity by using pylorus ligation as antisecretory model and ethanol induced ulceration models as cytoprotective model. ...

Sonali Thorat, Dhananjay Deshmukh*, Dushant Gaikwad and Nirmala Grampurohit

VJSM’S Vishal Institute of Pharmaceutical Education & Research Ale, Junnar, Pune- 411 412 Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1120-24

1120-1124

1315

498

33.

ASSESSMENT OF CYTOTOXIC ACTIVITY OF TWO MEDICINAL PLANTS USING BRINE SHRIMP (ARTEMIA SALINA) AS AN EXPERIMENTAL TOOL

Solanum sisymbriifolium (Solanaceae) and Jatropha gossypifolia (Euphorbiaceae) have long been used in folkloric medicine for the treatment of various ailments. The purpose of the present study was to evaluate the cytotoxic activity of the plants and to make available the process of data analysis of cytotoxic studies to the researchers. A general toxicity of the extracts was assessed by a simple an...

Apurba Sarker Apu*, Shakhawat Hossan Bhuyan, Farjana Khatun, Mahmuda Sultana Liza, Maima Matin, Md. Faruq Hossain

Department of Pharmacy, East West University, Plot No-A/2, Main Road, Jahurul Islam City, Aftabnagar, Dhaka-1212, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1125-30

1125-1130

2642

910

34.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF TRIMETAZIDINE IN PHARMACEUTICAL DOSAGE FORMS

A simple and sensitive UV spectrophotometric method has been developed for the quantitative estimation of trimetazidine in bulk drug and pharmaceutical dosage forms (tablets). Trimetazidine exhibited absorption maximum at 269 nm in 0.1 N HCl and obeyed Beer’s law in concentration range 5-25 µg/ml. The result of analysis in this method has been validated statistically and by recovery studies. Th...

Y. Naga Prasanna*, S. Archana, Y. Poornima, S. Lalitha and M. Lalitha

Research Lab., Aditya Institute of Pharmaceutical Sciences & Research, ADB Road, Surampalem, Kakinada, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1131-34

1131-1134

1878

778

35.

PHYTOCHEMICALS INVESTIGATION AND TLC ANALYSIS OF JASMINUM MULTIFLORUM LEAVES

Jasminum multiflorum belongs to the Oleaceae family. It is used as a traditional medicine from ancient times. It is a large evergreen twinner shrub found throughout India. Present study reports the phytochemical properties which have been carried out on the leaves extract using ethanol, methanol, ethyl acetate, acetone and n-hexane. The phytochemicals analysis show the presence of Phenols, Saponin...

Sunil H. Ganatra*, Shweta P. Durge and Archana M. Ramteke

Department of Chemistry, Institute of Science, R. T. Road, Civil Lines, (Affiliated to Rashtrasant Tukdoji Maharaj Nagpur University), Nagpur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1135-39

1135-1139

2093

730

36.

IN-VITRO RELEASE CHARACTERIZATION OF KETOROLAC TROMETHAMINE LOADED MATRIX TABLETS

The present investigation highlighted the formulation and release characterization of Ketorolac Tromethamine loaded matrix tablet. Various formulations of tablets were prepared by direct compression method along with Kollidon SR and Hydroxy Propyl Methyl Cellulose (HPMC) as release retardant polymers. Each of the formulated tablets contains 50mg Ketorolac Tromethamine. The evaluation involved phys...

Sayed Koushik Ahamed, Sujan Banik and Mohammad Salim Hossain*

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1140-47

1140-1147

1910

532

37.

EVALUATION OF THROMBOLYTIC ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF METHANOL EXTRACT OF STEMS OF TINOSPORA CRISPA

Tinospora crispa, a plant belonging to the family of Menispermaceae is a well-known traditional medicinal plant used in Bangladesh. The methanolic extracts of stems of the plantwere evaluated for their thrombolytic and preliminary cytotoxic activities. The thrombolytic activity was evaluated using the in vitro clot lysis model while while the screening of cytotoxic activity was done using brine sh...

Md. Ariful Islam , Zobaer A. Mahmud*, S.M. Abdur Rahman , Md. Monirujjaman and Sajal K. Saha

Lecturer, Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Ramna, Dhaka-1000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1148-53

1148-1153

2240

580

38.

METAL COMPLEXES OF HETEROCYCLIC UNSATURATED 1, 3- DIKETONES

The present investigation is mainly on the synthesis, characterization and anti-microbial screening of certain new curcuminoid analogues containing imidazole, pyrrole and thiophene rings and their metal complexes. The ability of such heterocyclic β-dicarbonyl compounds and their metal ions to influence many of complex reaction upon which the vital processes of micro-organisms depends is the motiv...

K.L. Krishnakumar* and Mathew Paul

Assistant Professor, Department of Chemistry, Nehru College of Pharmacy, Thrissur, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1154-58

1154-1158

1357

484

39.

IN VITRO CYTOTOXIC EFFECT OF METHANOLIC CRUDE EXTRACTS OF OCIMUM SANCTUM

The aim of this research is to observe the cytotoxic activities of methanolic crude extracts of Ocimum sanctum (Family: Lamiaceae). The leaves of Ocimum sanctum was extracted with organic solvent (methanol) and the extracts were fractionated by using solvent-solvent partition. The n-hexane, ethyl acetate, and chloroform soluble fractions of methanolic crude extract of Ocimum sanctum were screened ...

Aparna Debnath and Mohammad Musarraf Hussain*

Assistant Professor, Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1159-63

1159-1163

1464

575

40.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TRIMETAZIDINE BY EXTRACTIVE SPECTROPHOTOMETRY

Rapid, simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Trimetazidine in pure and pharmaceutical formulations. Various methods were developed for estimation of trimetazidine .but a simple extractive photometric method using has not been developed .This method is based on the formation of chloroform soluble ion pair complex of Trimetazidine with...

Y. Naga Prasanna*, S. Archana, G.S. Sowjanya, S. Lalitha, M. Lalitha

Research Lab., Aditya Institute of Pharmaceutical Sciences & Research, ADB Road, Surampalem, Kakinada, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1164-67

1164-1167

1836

554

41.

DEVELOPMENT AND EVALUATION OF TASTE MASKED ORODISPERSIBLE TABLET OF OFLOXACIN

Ofloxacin is an antibacterial agent used to treat infections. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form.  The  purpose  of  present  research  work  was  to formulate tasteless complexes of  ofloxacin with  indion 204  ion  exchange  resin. The drug  loading onto ion-exchange resin  was optimized  for  mixing  time,   activat...

S.P. Dhamane*, M.P. Wagh , G.P. Asnani , A. S. Kulkarni , B. S. Patil and A.S. Gadekar

JSPM’s Jayawantrao Sawant College of Pharmacy & Research, Hadapsar, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1168-75

1168-1175

1648

569

42.

PREVALENCE AND ASSOCIATED FACTORS OF MENTAL DISTRESS AMONG LEPROSY PATIENTS AT ALERT HOSPITAL OUT PATIENT CLINIC ADDIS ABABA, ETHIOPIA, 2011

Background: Leprosy is one of the infectious diseases of public health importance; it is the leading cause of permanent physical disability as aresult of nerve damage. Individuals with leprosy have emotional stress and anxiety, which may lead to both psychological and psychiatric co-morbidity. Objective: This study was conducted to estimate the prevalence of mental distress among leprosy patien...

Ashenafi Damte*, Berihun , Haftu Berhe and Haftom G/Hiwot

Department of Nursing, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1176-82

1176-1182

1964

829

43.

SYNTHESIS AND ANTIMICROBIAL STUDIES OF SOME NEW HALOGENATED ISOXAZOLINE DERIVATIVES

A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this rea...

M.M. Kendre, Shahid Shaikh, N.N. Shah and M.A. Baseer*

Organic Chemistry Research Laboratory, Yeshwant Mahavidyalaya, Nanded-431602, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1183-85

1183-1185

1353

573

44.

FORMULATION AND EVALUATION OF POLYHERBAL GEL FOR ANTI – INFLAMMATORY ACTIVITY

In the present study, three medicinal plants Cynodon dactylon (L.) Pers, Cassia tora Linn. and Cassia alata Linn having significant anti-inflammatory potential were selected to be formulated as polyherbal gels. The gels were prepared using the dried methanolic extract of Cassia tora Linn, Cassia alata Linn and Cynodon dactylon (L.) Pers. Polyherbal gel formulations were evaluated for its pH, appea...

Gouri Dixit*, Ganesh Misal, Vijay Gulkari and Kanchan Upadhye

Department of Pharmaceutics, J. L. Chaturvedi College of Pharmacy, Electronic zone, MIDC, Hingna road, Nagpur-440016, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1186-91

1186-1191

2706

837

45.

THEORETICAL STUDY OF THE ABSORPTION SPECTRA OF TRIAMTERENE

Time dependent density functional theory (TDDFT) calculations have been carried out to study the electronic structure and the UV absorption spectra of Triamterene. The UV spectra have been investigated with inclusion of solvent effect. The B3LYP functional with a 6-31G(d, p) basis sets have been used to compute absorption energies. The solvent effects have been described within the polarizable con...

M. Ramegowda

Post-Graduate Department of Physics, Government College (Autonomous), Mandya-571401, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1192-95

1192-1195

1806

776

46.

ANTI-DIABETIC ACTIVITY OF RIBES NIGRUM FRUIT EXTRACT IN ALLOXAN INDUCED DIABETIC RATS

Different doses of Ethanolic fraction of Ribes nigrum fruit were evaluated for hypoglycemic activity in Alloxan induced diabetic rats. The oral administration of Ethanolic extract at a dosage of 100mg/kg and 500mg/kg body weight exhibited significantly reduced the serum glucose level in both acute (1, 3, 5 h) and sub-acute (1, 3, 5, 7 days) treatments. Perform the Histopathological study of pancre...

G. Sivalingam* and N. Sriram

Smt. Sarojini Ramulamma College of Pharmacy, Seshadrinagar, Mahabubnagar, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1196-01

1196-1201

1712

540

47.

A COMPREHENSIVE ETHNOMEDICINAL DOCUMENTATION OF MEDICINAL PLANTS OF ISLAMIC UNIVERSITY, REGION, BANGLADESH

An ethnobotanical survey was carried out through semi-structured questionnaire and the guided field-walk method in Islamic University, Kushtia, Bangladesh to document the utilization of medicinal plants by local people for general ailments. A total of 87 species belonging to 51 families with their local names, useable parts and mode of application were recorded for their usages for curing at least...

Gazi Ziaul Haque Masum*, Biplab Kumar Dash, Shital Kumar Barman and Monokesh Kumer Sen

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1202-09

1202-1209

1726

554

48.

CHEMICAL COMPOSITION AND ANTIMICROBIAL PROPERTIES OF DIFFERENT BASIL OILS

The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities. Five oil chemotypes were identified and classified as follows in line with their principal components: estragole type; linalool/estragole type; methyleugenol type; methyleugenol/t-anethole type; taneth...

H.C. Srivastava, Pankaj Shukla, Ajay Singh Maurya and Sonia Tripathi*

Department of Chemistry, Research lab, D.B.S. College (R.L.D.B.S.C.), Kanpur- 208 006, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1210-16

1210-1216

1271

356

49.

NATURAL OCCURRENCE OF MYCOFLORA AND DETERIORATION OF TOTAL ALKALOIDS AND GLYCOSIDES AMOUNTS IN STEREOSPERMUM CHELONOIDES DC. ROOTS UNDER STORAGE

In the present study, total 15 fungal species isolated from roots of drug Stereospermum chelonoides DC. such as: Fusarium  solani, F. lateritum,  F. semitectum, F. oxysporum, Aspergillus ochraceus, A. niger, A. terreus, Theilavia terricola, Papulaspora immerse, Scytallidium thermophilum, Didymostilbe sp., Cunningamella elegans,  Aphanomyces sp., Sordaria fimicola and Mucor praini. Species of Fu...

M. Rashidi* and S.S. Deokule

Department of Botany, University of Pune, Pune-411007, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1217-20

1217-1220

1217

426

50.

BENEFICIAL EXPLORATION OF NATURAL PESTICIDES FROM HIGHER PLANT

The methanolic extract (MeOH) of the bark of Holoptelea integrifolia (Roxb.) Planch and its partitions namely n-hexane (Hx), ethyl acetate (EtOAC), butanol (BuOH) and water (H2O) was screened for various in vitro biological activities including general cytotoxicity (brine shrimp lethality assay), phytotoxicity (lemna minor bioassay), nematicidal and insecticidal (Tribolium castaneum H., Rhyzoperth...

Maryam Ahmed*, Ghazala H. Rizwani , Shahina Fayyaz, Firoza Qazi and Shaukat Mahmud

Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1221-26

1221-1226

1391

515

51.

DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING RP-HPLC ASSAY METHOD FOR ENTACAPONE IN ENTACAPONE TABLETS

A new, simple, precise, rapid, accurate and stability-indicating RP-HPLC method has been developed for the determination of Entacapone in presence of its degradation products or other pharmaceutical excipients. Stress studies were performed on Entacapone tablets and it was found that it degrades sufficiently in acidic, alkaline and oxidation conditions, while negligible degradation was observed in...

Raj Kumar Dhawan*, S. Ravi , T. Subburaju , H. Revathi , C. Arul and N. Ganapathi Rao

Research scholar – Karpagam University), Plot No.1054, behind ICICI ATM, Pragathi Nagar, Kukatpally, Hyderabad – 500072, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1227-32

1227-1232

3092

747

52.

ASSESSMENT OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF DIFFERENT FRACTIONS OF CRUDE EXTRACT OF STEPHANIA JAPONICA STEM

The different fractions of crude methanol extract of stem of Stephania japonica (Thunb.) Miers (Menispermaceae) was screened for its analgesic and antidiarrhoeal activities. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at the dose of 250 and 500 mg/kg body weight comparable to the standard drug diclofenac sodium at the do...

Bishwajit Bokshi, S.M. Abdur Rahman*, Samir Kumar Sadhu, Ashif Muhammad and Md. Ariful Islam

Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1233-38

1233-1238

1300

435