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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 5 (2014) - Issue 3, March

Review Articles

 
Title
Views
PDF
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1.

LEAD AS A DEVELOPMENTAL TOXICANT: A REVIEW

A toxic substance is one which can produce its adverse effects in biological systems by interfering with their structure and function, which may lead to mortality. From the biological point of view, it can be consider that no chemical is either completely safe or harmful .The safe or harmful nature of toxic substance depends on the doses, duration and the time when animal is exposed to the particu...

Ragini Sharma and Sheetal Mogra *

Environmental and Developmental Toxicology Research Laboratory, Department of Zoology, University College of Science, Mohanlal Sukhadia University, Udaipur, 313001, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).636-42

636-642

2006

845

2.

AN OVERVIEW ON MICROBIAL FIBRINOLYTIC PROTEASES

Microbial fibrinolytic proteases are of considerable interest in view of their specific activity and stability at biological pH. This review describes different isolation methods which enable the screening and selection of promising organisms for industrial production. Further, strain improvement using mutagenesis and/or recombinant DNA technology can be applied to augment the efficiency of the pr...

E. Venkata Naga Raju*and G. Divakar

Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522 510, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).643-56

643-656

3658

776

3.

CLINICAL EVIDENCES OF OXIDATIVE STRESS AS A BIOMARKER IN VARIOUS TYPES OF CANCERS: A REVIEW

Free radicals play an effective role in the pathogenesis of different pathological diseases together with cancer. Potential biological targets for free radical attack comprise lipids, proteins and nucleic acids. Free radical induced lipid peroxidation causes a loss of cell homeostasis by modifying the structure and functions of cell membrane. The most important characteristic of lipid peroxidation...

Sachin Sharma , Archana Shrivastav and B.R. Shrivastav*

Director, Cancer Hospital & Research Institute, Gwalior, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).657-65

657-665

2251

665

4.

A BRIEF REVIEW ON RECENT SYNTHESIS OF 2-AZETIDINONE DERIVATIVES

The chemistry of β-lactams has taken an prestigious place in organic and medicinal chemistry so the review on recent methods in the synthesis of 2-Azetidinone derivatives rendered as a lead molecule for designing potential bioactive agents and it accompanying additional various synthetic information and its orientations would encompass great deal of help to researchers, chemists and pharmacologis...

D.S. Salunkhe and P.B. Piste*

P.G. Department of Chemistry, Y.C. Institute of Science, Satara-415 001, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).666-89

666-689

5175

4572

5.

A REVIEW ON HEPATOPROTECTIVE ACTIVITY

Liver, the largest gland functioning as an organ of storage, manufacturing and biotransformation is a vulnerable target for injury. Chronic alcohol consumption, exposure to toxic chemicals and certain drugs like paracetamol, tetracycline, antitubercular drugs, chemotherapeutic agents, NSAIDS, damage the liver cells (hepatocytes) in long run. Drug induced liver injury is a major health problem, the...

Vuyyuri Bhaargavi*, G.S.L. Jyotsna and Reshma Tripurana

School of Pharmaceutical Sciences and Technologies, Jawaharlal Nehru Technological University Kakinada, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).690-02

690-702

4148

2112

6.

THE CARCINOGENIC POTENTIAL OF E6 & E7 GENES OF HIGH-RISK HPV COMPARED WITH E6, E7 GENES OF LOW-RISK HPV IN HUMAN CERVICAL CANCER: A REVIEW

Human papillomavirus is one of the most common causes of sexually transmitted disease in both men and women worldwide. Genital HPV types are divided into high and low-risk types, on the basis of oncogenic gene potential. Molecular & epidemiologic studies have confirmed the interaction between high risk HPV types (especially HPV-16 & 18) and cervical squamous cell low risk strain. In high g...

Sher Singh Gill , A.M. Jana*, Archana Shrivastav , Sachin Sharma and Arvind Sharma

155/B Sharda Vihar, City Center, New High Court Road, Gwalior, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).703-12

703-712

2344

595

7.

MEDICINAL PLANTS AS NATURAL ANTI-DIABETIC AGENTS

Diabetes is a growing health concern worldwide and now emerging as an epidemic world over. The management of diabetes is still a major challenge. Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization (WHO), up to 90%...

Nishu Khera and Aruna Bhatia*

Immunology and Immunotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala-147 002, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).713-29

713-729

3285

2133

8.

INDIAN TRADITIONAL THERAPIES AND BIO-PROSPECTING: THEIR ROLE IN DRUG DEVELOPMENT RESEARCH

Exploration of biological diversity for identification of novel bioactive molecules or therapeutically more potential than the marketed products is a continuous ongoing process for drug development research. Indian traditional therapies have been a part of our lifestyle since ages. Due to their knowing ability and applications, this knowledge has long been used as thriving sources for discovery of...

Chetan Sharma , Kandhikonda Rajendar , Tejaswita Kumari and K.R. Arya*

Principal Scientist, Botany Division, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow-226031,Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).730-41

730-741

2003

1140

9.

SHATAVARI (ASPARAGUS RACEMOSUS WILD): A REVIEW ON ITS CULTIVATION, MORPHOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGICAL IMPORTANCE

Asparagus racemosus, a climbing Ayurvedic plant, is known for its numerous activities such as hyperlipidemia, hypertension, angina, dysmenorrhea, anxiety disorders, benign prostatic hyperplasia (BPH), leucorrhoea and urinary tract infections. This plant possesses a wide range of secondary metabolites inclusive of steroids, alkaloids, dihydrophenanthrene derivatives, flavonoids, furan derivatives a...

Ramit Singla and Vikas Jaitak*

Centre for Chemical and Pharmaceutical Sciences, School of Basics and Applied Sciences, Central University of Punjab, Bathinda-151001, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).742-57

742-757

8019

1360

11.

POTENTIAL HERBAL HEPATOPROTECTIVE PLANTS: AN OVERVIEW

Hepatic diseases (Liver diseases) are a major worldwide health problem, with high endemicity in developing countries. Hepatic disease is a term for a collection of conditions, diseases, and infections that affect the cells, tissues structures, or functions of the liver. Liver has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for dig...

Rajesh Kumar Soni*, Vihangesh Dixit, Raghuveer Irchhaiya and Shashi Alok

Department of Pharmacognosy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).774-89

774-789

2611

1354

12.

PROTEIN NANOPARTICLES: FUTURE OF DRUG DELIVERY SYSTEMS

Nanoparticles have advantages, such as small size, high surface area, and modification using functional groups for high capacity or selectivity. Nanoparticles with Proteins are especially worthy of notice because they can be used for site specific targeting. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmaco-dynamic pr...

Alok Mahor *, Shashi Alok , Sunil Prajapati , Amita Verma , Poonam Yadav and Madhuri Shringrishi

Assistant Professor, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).790-98

790-798

2664

699

Research Articles

 
Title
Views
PDF
Cited
13.

FORMULATION AND IN VITRO EVALUATION OF ASPIRIN AND ISOSORBIDE 5-MONO-NITRATE SUSTAINED BILAYER TABLETS

In this study, aspirin (AS) and isosorbide 5-mononitrate(ISM) sustained bilayer tablets were developed by wet granulation and compression technique, the influence of the contents of PVPP on the dissolution of AS from the tablets was investigated. An orthogonal experiment design was used to optimize ISM sustained release layer. The tablets were tested for their drug content, hardness, thickness, fr...

Liandong Hu *, Qiaofeng Hu , Dongqian Kong

School of Pharmaceutical Sciences & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, No.180, WuSi Road, Baoding- 071002, PR China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).799-04

799-804

2120

595

14.

ANATOMICAL CHARACTERIZATION AND MICROCHEMISTRY OF PEPEROMIA PELLUCIDA (L.) H.B.K. (PIPERACEAE)

Peperomia pellucida L. (H.B.K.)is an arboreal species occurring in the secondary vegetation in Amazonia. This study aims to perform anatomy analysis by light microscopy and microchemistry analysis of leaves and petiole of P. pellucida. It was observed that the cells, on the adaxial surface, are juxtaposed with irregular shape and heterodimensional and straight walls and, the abaxial surface is for...

Rosali Maria Ferreira da Silva*, Giovanna Chistinne Rocha de Medeiros, Salvana. Priscylla Manso Costa , Janaina Almeida Gell ., José Otávio Carrera Silva Júnio and Pedro José Rolim Neto

SN – Cidade Universitária – Recife/PE - CEP: 50740-521; 2Rua augusto corrêa, 01 - Guamá – Belém/PA – CEP: 66075-110; 3Rua augusto corrêa, 01 - Guamá – Belém/PA – CEP: 66075-110, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).805-10

805-810

2117

753

15.

NOCTURNAL ENURESIS, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF PANDANUS ODORATISSIMUS L. PEDUNCLE

Nocturnal Enuresis treatment activity in rabbits by measuring the changes in urine volume and concentrations of electrolytes as well as bladder capacities. In addition, antioxidant activity was measured using free radical scavenging (DPPH method) and antimicrobial activity against human bacterial pathogens using agar diffusion technique. Pandanus Odoratissimus L. peduncle showed no toxic effect wi...

Amina El-Shaibany

Department of Pharmacognosy, Faculty of Pharmacy, University of Sana’a, Sana’a, Yemen

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).811-18

811-818

1525

517

16.

EXTRACTS OF ROSMARINUS OFFICINALIS, RHEUM RHAPONTICUM, AND ORIGANUM MAJORANA EXHIBIT SIGNIFICANT ANTI-STAPHYLOCOCCAL ACTIVITY

Background: Bacterial resistance to antimicrobial agents is on the rise and this is causing serious complications resulting in increased morbidity and mortality of bacterial infections. There is a need for new antimicrobial molecules in order to fight against Multi-Drug-Resistant Organisms. The Mediterranean area is rich in a variety of medicinal plants and this may represent a potential for new c...

R.M. Abdel-Massih* and A. Abraham

Department of Biology, Faculty of Sciences, University of Balamand, P.O. Box: 100 El-Koura, Lebanon

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).819-28

819-828

1657

792

17.

NEUROPROTECTIVE EVALUATION OF ETHANOLIC LEAF EXTRACT OF DALBERGIA SISSOO IN MONOSODIUM GLUTAMATE INDUCED NEUROTOXICITY IN RATS

Neurodegenerative disorders are heterogeneous group of diseases of the nervous system, including the brain, spinal cord and peripheral nerves that have many different etiologies. Due to the prevalence, morbidity, and mortality of the neurodegenerative diseases, they represent significant medical, social, and financial burden on the society. Dalbergia sissoo (family: Fabaceae) is an Asian deciduous...

V.S.S. Swaroop Thonda*, S. Harish Kumar, M. Handral and Abhijit Sonowal

Department of Pharmacology, PES College of Pharmacy, Hanumanthnagar, Bangalore, Karnataka, Pin code: 560050, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).829-38

829-838

1790

809

18.

EVALUATION OF IN VITRO ANTIOXIDANT PROPERTIES OF CALLUS CULTURES OF AN ENDANGERED MEDICINAL TREE SPECIES, HILDEGARDIA POPULIFOLIA (ROXB.) SCHOTT & ENDL.

Protocol for efficient callogenesis in Hildegardia populifolia has been developed by using leaf, node, internode and petiole explants. Preliminary phytochemical analysis and quantitative estimation of flavonoids, phenols and tannins were made along with the evaluation of antioxidant properties by DPPH• and ABTS•+ assays in in vitro callus cultures of the same species. It is an indigenous endan...

M. Saradha , P. Ranjitham and S. Paulsamy*

Department of Botany, Kongunadu Arts and Science College, Coimbatore – 641 029, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).839-48

839-848

1642

679

19.

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF CHOLINE FENOFIBRATE IN PHARMACEUTICAL DOSAGE FORMS BY RP-HPLC

A simple, precise, accurate and stability indicating RP-HPLC method was developed and validated for the determination of choline fenofibrate in delayed release tablet dosage form. Separation was achieved under optimized chromatographic conditions on an inertsil ODS column (150 x 4.6 mm, 5µ particle size). The mobile phase consisted of potassium dihydrogen phosphate buffer pH 2.5 and acetonitrile ...

E. Samyukta and Prathima Srinivas*

Sri Venkateshwara College of Pharmacy and Research Center, Madhapur, Hyderabad-81, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).849-54

849-854

1884

579

20.

ANTIBIOTIC SUSCEPTIBILITY PATTERNS OF SALMONELLA TYPHI AMONG PATIENTS IN THREE HOSPITALS IN KUMASI, GHANA

Salmonella typhi, causative agent of typhoid fever, a predominantly human communicable disease, is endemic in Africa and Asia. S. typhi is of clinical importance partly due to its mode of infection and partly due to the fact that human activities such as poor hygienic conditions are essential in the transmission and perpetuation of the pathogen. More so antibiotic resistant strains of S. typhi hav...

S.B. Bayaa Martin Saana*1, F. Adu 2, S. Y. Gbedema 2 and F.G. Duredoh 2

Department of Dispensing Technology, Wa Polytechnic, Wa, Upper West Region, Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).855-60

855-860

1808

491

21.

COMPARATIVE US0E OF DIFFERENT ANTIHYPERTENSIVE COMBINATIONS AT SAVAR AREA, DHAKA, BANGLADESH

Antihypertensive agents are class of drugs that are used to treat hypertension (high blood pressure) as well as other CVS disorders. Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischemic heart disease by 21%, an...

Md. Jahir Alam*, Md. Azizur Rahman and Rozina Parul

Department of Pharmacy, North South University, Bashundhara R/A, Dhaka-1229, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).861-64

861-864

1419

467

22.

EVALUATION OF RATIONAL USAGE OF ANTIMICROBIAL AGENTS IN THE MEDICINE DEPARTMENT AT TERTIARY TEACHING CARE HOSPITAL, GUJRAT

Background: Prescription of drugs which needs to be continuously assessed and refined according to disease progression. It is not only reflects the physician’s knowledge about drugs but also know the pathophysiology of diseases and attitude towards rational prescribing. Methods-: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor ...

Vipul Prajapati* and J.D. Bhatt

Assistant professor, Department of Pharmacology, AMC MET Medical College, Ahmedabad-380008

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).865-73

865-873

1228

405

23.

FORMULATION AND IN-VITRO OPTIMIZATION OF EXTENDED RELEASE TABLETS OF PRAMIPEXOLE DIHYDROCHLORIDE MONOHYDRATE FOR PARKINSON’S DISEASE

The main aim of the extended release tablets is to reduce the dose frequency and to improve the patient compliance. The objective of the present study was to formulate and optimize the extended release tablets of Pramipexole dihydrochloride monohydrate for 24hrs, which made the advantage of this formulation as once daily with more patient compliance. The combination of different hydrophilic polyme...

T. Sudhamani*, Jeevan Kumar Dande and S. Rajarajan

Assistant Professor, Department of Pharmaceutics, The Erode College of Pharmacy and Research, Vepampalayam, Vallipurathanpalyam (po), Erode - 638 112, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).874-81

874-881

1793

550

24.

INVESTIGATION OF MICROSCOPICAL AND PHYSICOCHEMICAL CHARACTERISTICS OF PLANTS WITH ANTI-DIABETIC ACTIVITY

Herbal medicines are gaining more and more attention all over the world, due to their long historical clinical usage and comparatively less side effects. Standardization of herbal drugs and their quality control is needed with proper integration of modern scientific techniques and traditional knowledge. The analysis and quality control of herbal medicines are moving towards an integrative and comp...

Shreeda Adhyapak* and Vidya Dighe

Department of Chemistry, Ramnarain Ruia College, Matunga, Mumbai-400 019, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).882-88

882-888

1337

426

25.

ANTIDEPRESSANT ACTIVITY OF DURENTA REPENS LINN.

The pet ether and chloroform extracts of Durenta repens leaves was screened for antidepressant action in tail suspension model. Both the extracts showed antidepressant action at the dose of 200mg/kg. Chloroform extract produced significant (p<0.001) mobilisation of the animals when compared with that of the standard drug Imipramine (10mg/kg) and acts as a potent centrally acting antidepressant ...

Nikita A. Pendharkar*and H. Padmalatha

Department of Pharmaceutical Sciences, JJT University, Jhunjhunu, Chudela 333001 Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).889-91

889-891

1176

376

26.

IMPACT OF ALCOHOL ON RAT HEART AND AORTIC TISSUE ACETYLCHOLINE CONTENT LEVELS IN VITRO AND IN VIVO

Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of senso...

M. Yugandhar*, M. Rajeswara Rao

Department of Zoology, S.V. University, Tirupati – 517502, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).892-95

892-895

1225

373

27.

IN VIVO ANTIINFLAMMATORY EFFECT OF EMU OIL (DROMAIS NOVAEHOLLANDIAE) AND VIRGIN COCONUT OIL (COCOS NUCIFERA) ON PHORBOL ESTER INDUCED ACUTE INFLAMMATORY MODEL

Inflammation is a cellular reaction to injury and plays a central role in pathophysiology of a variety of diseases.Oil derived from Emu (Dromais novaehollandiae) fat, is reported to have healing property. The present investigation was performed to demonstrate in vivo anti-inflammatory effect of Emu oil using phorbol ester induced acute inflammatory ear edema model. Also, the efficacy of Emu oil wa...

P. Logeswari*, V. Dinesh Kumar , P.T.A. Usha and Prathap Kumar

Research Scholar, Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Mannuthy, Thrissur, Kerala-680651, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).896-99

896-899

1526

597

28.

FORMULATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE FLOATING TABLETS OF LAMIVUDINE

The aim of the present work is to increase the gastric residence time of Lamivudine by preparing it into gastro retentive floating tablets whereby making it available at its site of absorption and to achieve an extended action for a time period of 24hrs and to reduce the dosing frequency to once a day, using release retardant polymers METHOCEL, POLYOX and CARBOPOL. The compatibility of the drug wi...

S.N.V. Suresh and K. Veerreddy

Department of Pharmaceutics, VJ’s College of Pharmacy, Rajahmundry, E.G.Dt, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).900-06

900-906

1466

503

29.

SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE, ITOPRIDE HYDROCHLORIDE AND MOSAPRIDE CITRATE BY RP-HPLC METHOD: OPTIMIZATION, DEVELOPMENT, VALIDATION AND APPLICATION TO LABORATORY SAMPLE.

A simple, rapid, accurate, precise and economical RP- HPLC method with UV detection was optimized, developed and validated as per ICH-Q2 guideline for the simultaneous estimation of Esomeprazole magnesium trihydrate (ESO), Itopride hydrochloride (ITO) and Mosapride citrate (MOSA) in laboratory sample. An optimum condition of separation and detection was developed on a reverse-phase Supelco 516 C18...

Darshan Gohil, Prachi Bhamre, Reshma Jain and Sadhana Rajput*

Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara – 390 002, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).907-12

907-912

1694

589

30.

A COMPARATIVE STUDY ON ANTIBACTERIAL ACTIVITIES AND CYTOTOXIC PROPERTEIS OF VARIOUS LEAVES EXTRACTS OF AVERRHOA BILIMBI

The study was carried out to assess the antibacterial & cytotoxic activities of extracts from leaf parts of the plant, Averrhoa bilimbi. Ethanol, methanol and water were used as solvents and antibacterial & cytotoxic effects were measured using disc diffusion test & brine shrimp lethality bioassay (BSLB). The susceptibility of the microorganisms to the extracts of this plant was compar...

Md. Abdullah Aziz, Shahariar Rahman, Mahfuzul Islam and Anjuman Ara Begum*

Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).913-18

913-918

1921

1413

31.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING REVERSE-PHASE HPLC METHOD FOR THE DETERMINATION OF PRASUGREL HYDROCHLORIDE AND ITS RELATED SUBSTANCES

A gradient reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the determination of Prasugrel hydrochloride and its related substances. The well chromatographic separation of prasugrel from its seven related substances and degradation products was achieved on Sunfire C18, 5mm (250mm x 4.6mm) column temperature maintained at 45°C with a mobil...

K. Chandra Sekhar Reddy*, S. R. Pavan Kumar Kothapalli, Jagadeesh Kumar Vundavilli , N. Sreenivas , Hemant Kumar Sharma and K. Mukkanti

Senior scientist, Analytical Research Department, Aurobindo Pharma Ltd Research Centre-II, Survey No: 71 & 72, Indrakaran village, Sangareddy mandal, Medak-502329, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).919-27

919-927

2275

801

32.

APPLICATION OF SURFACE RESPONSE METHODOLOGY FOR SPRAY DRIED- FLUID BED PROCESSED TECHNOLOGY OF MOUTH DISSOLVING PLATFORM FOR SILDENAFIL CITRATE IN PULMONARY HYPERTENSION

Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (MDTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self-administration without water or ...

Vikram Gharge* Peeyush Sharma , Indrajeet Gonjari and Anil Bhandari

Ph. D Research Scholar, Tulip A-1 Part I, Flat 7; Sukhwani Campus, Vallabhnagar, Pimperi Pune- 18, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).928-41

928-941

1552

546

33.

A SYNERGISTIC APPROACH TO KINETIC AND MECHANISTIC STUDIES OF REGENERATION OF β-CAROTENE FROM TERT-BUTOXYL RADICAL INDUCED β-CAROTENE RADICAL CATION BY CHLOROGENIC ACID

The rates of oxidation of β-carotene and chlorogenic acid by tert-butoxyl radicals (t-BuO·) were studied by measuring the absorbance of β-carotene at 491 nm and chlorogenic acid at 328 nm spectrophotometrically. Radicals (t-BuO·) were generated by the photolysis of tert-butyl hydroperoxide (t-BuOOH) in presence of tert-butyl alcohol to scavenge OH·radicals. The rates and the quantum yields (f...

G. Vijayalakshmi*, M. Adinarayana and P. Jayaprakash Rao

Department of Chemistry, Nizam College, Basheerbagh, Osmania University, Hyderabad, 500 001, India, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).942-50

942-950

2144

502

34.

ANALYSIS OF DIFFERENT BRANDS OF PARACETAMOL 500mg TABLETS USED IN HYDERABAD, USING ULTRA VIOLET SPECTROPHOTOMETRIC AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC (HPLC) METHODS

The study involves quantitative analysis of seven different brands (samples) of Paracetamol 500mg tablets used in Hyderabad (India), using Ultra Violet Spectrophotometric and High Performance Liquid Chromatographic methods, in which the samples were dissolved in 0.1M NaOH and distilled water and their various absorbances determined at wavelength of 257nm and in HPLC by using methanol, water (60:40...

D. Akhilesh Kumar*, A. Santhosh Kumar Sreevatsav, M. Sanjay Kumar, P. Shiva Kumar, G. Shiva Shankar

Department of Pharmaceutical Analysis, MLR Institute of Pharmacy, Dundigal, Hyedrabad-500043, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).951-55

951-955

7797

795

35.

INFLUENCE OF INCREASING CONCENTRATIONS OF MAGNESIUM STEARATE AND TALCUM ON DISSOLUTION PROFILE AND PHYSICAL PARAMETERS OF METOPROLOL TARTRATE EXTENDED RELEASE MATRIX TABLETS

Metoprolol tartrate (MT) is cardio-selective β1 receptor antagonist used primarily in the management of chronic heart diseases like in the management of hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction and heart failure. It is only available as prescription drug. The objective of this study was to prepare sustained release matrix tablets of MT using hydrophilic polymer an...

Muhammad Yaseen*, Dilnawaz Shaikh and Muhammad Yaqoob

Hamdard Institute of Pharmaceutical Sciences- Hamdard University, Islamabad Campus, Islamabad Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).956-60

956-960

2139

406

36.

DIURETIC ACTIVITY OF METHANOLIC RHIZOME EXTRACT OF PICRORRHIZA KURROA ROYLE EX. BENTH.

Kidneys are the excretory organs of our body that serves the important functions such as elimination of waste products, regulation of fluid volume and electrolyte content of the extracellular fluid. Picrorrhiza kurroa (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate a...

A. Rajani, M. Vishnu Vardhan Reddy , M. Madhuri , K. Hemamalini and M. Swathi

Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, R.R. District, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).961-63

961-963

1279

363

37.

FORMULATION DEVELOPMENT AND QUALITY PROFILING OF PARACETAMOL – IBUPROFEN COMBINATION TABLETS

Opportunity is envisaged by some astute pharmaceuticals manufacturers to increase product portfolio and widen the spectrum of treatment of pains to cover analgesia, pyrexia and inflammation using one product. In this research work, paracetamol – ibuprofen combination tablet was designed and formulated, developed and profiled to address this anticipation thus satisfying the requirement of one pro...

Musibau A. Mustapha*, Oseremen A. Aluya and John E. Ihunde

Edo Pharmaceuticals Ltd., Uselu, Benin City, Edo State, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).964-69

964-969

3116

1082

38.

CORRELATION OF MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN TO THE THERAPEUTIC RESPONSE OF PATIENT WITH URINARY TRACT INFECTION CAUSED BY ESCHERICHIA COLI

The choice of an antibiotic depends solely on the identification of the species by determination of the sensitivity characteristics of the microorganism. Along with the determination of sensitivity pattern, understanding the susceptibility pattern of particular strain isolated from patient is equally important. Variation in patient and microorganism is known to be key factor for predicting the out...

Rashmi Sharma*, Sujata Sapkota, Dipesh Khanal

Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).970-76

970-976

2851

460

39.

SIMULTANEOUS DETERMINATION OF PHENOLIC COMPOUNDS IN CATHARANTHUS ROSEUS LEAVES BY HPLC METHOD

In Catharanthus roseus, Rutin, Quercetin and Kaempferol are the most important phenolic compounds with antioxidant activity. For simultaneous determination of Rutin, Quercetin and Kaempferol in Catharanthus roseus a simple and rapid HPLC method was developed. Phosphate buffer (pH=5.8) and solvent Acetonitrile are used in ratio of 55: 45 as mobile phase. Rutin, Quercetin and Kaempferol were determi...

A. Srinivasa Rao* and Mohammed Fazil Ahmed

Bhaskar Pharmacy College, Yeknapally, Moinabad (Mandal), R.R (Dist), Hyderabad 500075, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).976-81

977-881

1391

597

40.

PHYTOCHEMICAL STUDIES ON DELONIX ELATA BARK

Delonix elata bark was collected, authenticated, dried, coarse-finely powdered and extracted using 70% alcohol and subjected for preliminary phytochemical screening. Total phenolic and flavonoidal contents were determined using UV/ visible spectrophotometer. In addition the silica column chromatographic separation was carried out to separate the phytochemicals of D. elata bark extract. Prelimina...

Gopal Murugananthan* and Mohan Shamanna

Department of Pharmacognosy, PES College of Pharmacy, Hanumanthnagar, Bangalore - 560 050, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).982-88

982-988

1565

533

41.

SYNERGISM BETWEEN CASSIA FISTULA AND FLUCONAZOLE; “A NEW APPROACH AGAINST CANDIDIASIS”

Natural products have great potential against microbes and can be used to overcome the problem of drug resistant pathogens. They are helpful in reducing the toxicity of existing antifungal compounds. This present in vitro study demonstrated the synergistic effectiveness of Cassia fistula (CF) leaves extracts and fluconazole (Flu) against isolated Flu resistant strains (FRSs) of Candida albicans (C...

Yogesh Bansal*, Pratap Saini and Kirti Bansal

Department of Biochemistry, D.A.V. © Dental College and Hospital, Yamuna Nagar, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).989-94

989-994

1322

466

42.

SCREENING OF CYANOBACTERIA STRAINS FROM DELHI AND NCR FOR ANTI-BACTERIAL POTENTIAL

Cyanobacteria or blue green algae have an extraordinary potential of producing secondary metabolites which can be an ultimate source of newer drugs for future. The purified strain Anabaena showed best photoautotrophic growth at 28oC with specific growth and generation time were 0.098 and 10.0 hr respectively. The better biomass production and antibacterial activity on 30th days of culture. 16 cyan...

Sachin Chauhan , Ashu Vats , Pooja Dabas, Sonam Kumari , Shweta Tripathi , Naveen Kumar , Indu Malik , N.V.S.R.K. Prasad , Deepali* and K.V. Giri

Department of Life Science, Sri Venkateswara College, University of Delhi, Benito Juarez Road, New Delhi-110 021, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).995-00

995-1000

1240

457

43.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF BRINZOLAMIDE AND TIMOLOL BY HPLC FROM OPHTHALMIC PREPARATION

A fast, sensitive and accurate reverse phase liquid chromatographic method has been developed and validated for the simultaneous determination of Brinzolamide and Timolol maleate from ophthalmic preparation. Chromatographic separation of these two drugs were achieved on Zorbax Eclipse Plus, Agilent Technology (150mm x 4.6mm, 5μm) as stationary phase with a mobile phase comprising of triethylamine...

Rahima Khatun* and S.M. Ashraful Islam

Department of Pharmacy, University of Asia Pacific, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1001-07

1001-1007

1912

1288

44.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL SCHIFF BASES OF CEPHALEXIN

Cephalexin remain as one of the most versatile class of compounds against microbes and therefore, are useful substructures for further molecular exploration. A novel series of Schiff bases of cephalexin were synthesized. Thus condensation of 5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 7-[(amino phenyl acetyl) amino]-3-methyl-8-oxo, monohydrate with appropriate aldehydes afforded the S...

N.T. Arun* and B. Gowramma

Anna University – Bit Campus, Tiruchirappalli, Tamil Nadu – 620 024, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1008-14

1008-1014

1537

439

45.

CHRONOMODULATED CHEMOTHERAPY AND CONCOMITANT RADIOTHERAPY, FOR THE MANAGEMENT OF LOCALLY ADVANCED, HEAD AND NECK SQUAMOUS CELL CARCINOMA

Purpose: To compare the efficacy and toxicity of chronomodulated concomitant chemotherapy using weekly Cisplatin at 0600 hour and 1800 hour along with radical external beam radiotherapy (EBRT) in the management of locally advanced head and neck carcinoma (LAHNC). Material and method: Previously untreated, histopathologically proven 60 patients of LAHNC (stage III-IVB) were taken for definitive ...

Yashpal Verma *, Ashok K. Chauhan , Harmeet Singh , Ramesh Sabharwal 3 Mukesh Bharti , Paramjeet Kaur

Medical Officer, Department of Radiotherapy, Post-graduate Institute of Medical Sciences, Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1015-22

1015-1022

1728

580

46.

POTENTIAL PROTECTIVE EFFECT OF GUM ARABIC AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY IN WISTAR ALBINO RATS

Gum Arabic (GA) is a water-soluble polysaccharide, obtained from stems of Acacia senegal trees as gummy exudates. It is a beneficial adjunct to the low-protein diet for chronic renal failure patient because it reduces serum urea nitrogen level. It is also have a good protective activity against CCl4 and acetaminophen-induced hepatotoxicity in rats but it failed protect kidney from gentamicin-induc...

Mahmoud A. Elderbi*, Abdel-Wahab H. Mohamed , Abdul-Hadi A. Hadi and Mahmoud D. Dabobash

Lecturer of Toxicology in department of Pharmacology and Toxicology, faculty of Pharmacy, University of Benghazi, Benghazi, Libya

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1023-27

1023-1027

1447

461

47.

DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES BY SOLVENT DIFFUSION- EVAPORATION METHOD FOR TOPICAL DELIVERY

The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the topical delivery. Tristearin was used as solid lipid with soya lecithin by using surfactant, Poloxamer 188 (1%) and Tween 80 (0.5%). Solid lipid nanoparticles (SLN) loaded with Flucanazole were prepared by solvent diffusion- emulsification method. The properties of the SLNs such as particle size, zeta potential (Z...

Poonam Yadav*, Girish Soni, Raghuveer Irchhaiya, Alok Mahor and Shashi Alok

Institute of Pharmacy, Bundelkhand University, Jhansi- 284 128, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1028-34

1028-1034

2055

874

48.

PREPARATION & PHYSICOCHEMICAL CHARACTERIZATION OF POORLY WATER SOLUBLE DRUG BY USING SPRAY DRYING AND SOLVENT EVAPORATION METHODS

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. The various preparation techniques for solid dispersion and compiles some of the recent technology transfers. This research article investigates enhancement of the dissolution profile of atorvastatin using solid dispersion wit...

Sunita S. Shinde*, Amol S. Shete , Manisha V. Patil , Sharad Salunkhe and Deepak Indapure

Department of Pharmaceutics, Tatayasaheb Kore College of Pharmacy, Warananagar, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1035-44

1035-1044

1310

634

49.

HOMOLOGY MODELING AND ANALYSIS OF STRUCTURE PREDICTIONS OF KLF8 PROTEIN FROM HOMO SAPIENS

KLF proteins are highly conserved among mammals from human to mouse, with many KLFs also having homologs in Gallus gallus (Chicken), Danio rerio (Zebra fish), and Xenopus laevis (Frog). On the basis of functional characteristics, KLF proteins can be divided into three distinct groups. KLFs in group 1 (KLFs 3, 8, and 12) serve as transcriptional repressors through their interaction with the carboxy...

Vinod Kumar Jatav*, Lovekesh Parasher, Ankit Raje and Samraddhi Tiwari

Department of Biotechnology, Madhav Institute of Technology and Science, Gwalior, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1045-50

1045-1050

1673

400

50.

PRESCRIBING PATTERNS OF ANTIMICROBIALS IN SURGICAL DEPARTMENTS IN A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Background: Antimicrobials form an important group of drugs. Increasing prevalence of infections and emergence of resistance to antimicrobials has led to polypharmacy with respect to antimicrobial prescription. Aims and Objectives: To study the prescribing patterns, approval status, adherence to NLEM and WHO-EML and cost of antimicrobials prescribed in surgical departments. Methods: Data was...

Sangita G. Kamath*, H.V. Varun, Usha Rani D., Sathisha Aithal and Umakant N. Patil

Department of Pharmacology, SSIMS & RC, Davangere, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1051-58

1051-1058

1316

834

51.

CIGARETTE SMOKE EXTRACTS INDUCE AND REPRESS GENES IN HUMAN EMBRYONIC LUNG CELLS

Disastrous effects of tobacco consumption on health remain in the focus of preclinical and clinical research. Exposures to tobacco smoke are closely connected to acute and chronic smoke lung dysfunctions and the effects are not restricted to airway inflammation processes. The facts that smoke exposure result in aberrant gene expression and changes in cellular phenotype resulting in clinical patter...

Klaus Braun*. Agnes Hotz-Wagenblatt , Manfred Wiessler, Rüdiger Pipkorn , Dorde Komljenovic , Wolfhard Semmler and Waldemar Waldeck

German Cancer Research Center (DKFZ), Dept. of Medical Physics in Radiology, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany

DOI: k.braun@dkfz.de

1059-1076

1419

358

52.

ROLE OF SERUM BILIRUBIN IN CLINICALLY ADMITTED PATIENTS TO PREVENT THE RISK OF CARDIAC DISEASES

ABSTRACT: Background: Coronary artery disease /coronary vascular disease (CAD/CVD) remains the first killer and common silent disease in the world. The lipid profile plays the essential role in CAD development with lipid oxidation.  Lipid oxidation, which accepted as an important element of arterial plaque formation and atherosclerosis, is involved in the patho physiology of   CVD. Bilirubin...

Neha Sharma*, Sadhna Sood and Girdhar Gopal Kaushik

Department of Biochemistry, SRMS-Institute of Medical Sciences, Bareilly, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1077-82

1077-1082

1183

470

53.

IN-VITRO PROPAGATION OF TYLOPHORA OVATA (LIND.) HOOK. EX. STEUD – AN IMPORTANT MEDICINAL PLANT

Efficient in-vitro propagation of Tylophora ovata (Lind.) Hook. Ex. Steud was carried out in this present investigation.  Nodal segments from the healthy grown plants were used as explants for culturing.  Explants were cultured on standard Murashige and Skoog (MS) medium supplemented with different concentration of benzyl amino purine (BAP) and naphthalene acetic acid (NAA) for primary shoot pro...

R. Jeyachandran* and M. Bastin

Department of Botany, St. Joseph’s College (Autonomous), Tiruchirappalli – 620 002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1083-86

1083-1086

1296

351

54.

ANTIPYRETIC ACTIVITY OF THESPESIA POPULNEA FRUITS

In the present study, the alcoholic and aqueous extracts of Thespesia populnea were investigated for their antipyretic activity. Suspension of subcutaneous administration of brewer’s yeast in albino rat leads to pyrexia. Oral administration of extracts at a dose of 500 mg/kg body weight significantly reduced the elevated body temperature of rat. This antipyretic effect has been compared with ant...

E. N. Siju *, G. R.Rajalakshmi , Arun Shirwaikar

Assistant Professor and Head, Department of Pharmacology, Academy of Pharmaceutical Science, Pariyaram Medical College, Kannur, 670503, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1087-89

1087-1089

1356

495