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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 7 (2016) - Issue 11, November

Review Articles

 
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1.

FOLATE CONJUGATES: A BOON IN THE ANTI-CANCER THERAPEUTICS

Targeted delivery system is a promising strategy for improving cancer treatment and diagnostics. Molecular targeted drug delivery system has the potential to maximize the cancer treatment efficacy and minimize the toxicity to normal cells.  Folate receptor (FR), an established ovarian cancer marker, is frequently found to be overexpressed in other major epithelial tumors. Overexpression of FR- β...

Shikhar Tyagi*, Shalini Rawat and Sarika Saxena

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, U.P., India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4278-03

4278-03

4459

1425

2.

ANTIBIOTIC PRODUCTION BY RHIZOSPHERIC SOIL MICROFLORA – A REVIEW

The rhizosphere represents the thin layer of soil surrounding plant roots and the soil occupied by the roots, supports large active groups of microorganisms. The vast organic compounds (amino acids, sugars etc.) secreted by plant roots in the rhizosphere provide a food source for microorganisms increasing microbial biomass and their activity in the rhizosphere. Antibiotics are antimicrobial compou...

Geetanjali and Pranay Jain*

Department of Biotechnology, University Institute of Engineering and Technology, Kurukshetra University, Kurukshetra, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4304-14

4304-14

4564

1462

3.

MOLECULAR MARKERS FOR CAPECITABINE THERAPY: A REVIEW

Capecitabine an oral prodrug of 5- fluorouracil is widely used for the treatment of variety of solid tumors, particularly colorectal cancer. However it is not devoid of toxicities and may limit therapy. A little is known about predictors of toxicity, response and survival in patients treated with capecitabine. The pharmacogenetic testing methods can identify such variants and thus indicate those p...

S. Ramalakshmi *, S. Kavimani, Satish Srineevas, V. Vetriselvi and LVKS Bhaskar

K. K. College of Pharmacy, Gerugambakkam, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4315-26

4315-26

3280

1108

4.

NATURAL RESOURCES: AN ECOFRIENDLY AND SAFER ALTERNATE TO CONTROL PLANT DISEASES

As the focus of the world is shifting towards natural products and analogues, the demand of herbal medicine is also increasing and several plants have been screened for antifungal activity. Review of literature reports that plant extracts have been mostly screened for activity against human pathogenic bacteria and fungi. Compared to this, there are very few reports regarding inhibitory activity ag...

S. Mehta * and K. Sharma

Microbial Research Laboratory, Department of Botany Mohan Lal Sukhadia University, Udaipur Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4327-40

4327-40

3291

1441

5.

VERIFICATION STRATEGIES FOR ESTABLISHING RELIABILITY AND VALIDITY IN PHARMACEUTICAL MANUFACTURING PROCESS- AN ENROUTE TO REGULATORY COMPLIANCE

The Process validation involves a series of activities over the lifecycle of the product and process. The FDA guidance described three stages of process validation which includes Process Design, Process Qualification, and Continued Process Verification (CPV). The CPV stage is a never ending approach that continues throughout the entire commercial lifecycle of the product. CPV is dependent on compl...

K. Manoj

Department Of Quality Assurance, Alkem Laboratories Ltd, Dabhel, Daman (UT), India

DOI: 10.13040/IJPSR.0975-8232.7(11).4341-57

4341-57

4001

1475

6.

BELINOSTAT: A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA

Histone deacetylase inhibitors (HDACIs) are a group of agents that have exhibited antitumor activity in vivo and in vitro, directing to clinical trials estimating their efficacy in multiple cancer types. Belinostat is under global development with Spectrum Pharmaceuticals, currently approved by the U.S. Food and Drug Administration with indications for relapsed or refractory peripheral T-cell lymp...

A. Verma, M. Porwal *, A. Kumar, V. Rastogi, N. Verma, A. K. Mishra and K. K. Maheshwari

Faculty of Pharmacy, IFTM University, Lodhipur-Rajput, Moradabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4358-66

4358-66

2762

500

7.

GENUS HUNTERIA- A ETHNOPHARMACOLOGICAL, CHEMICAL AND PHARMACOLOGICAL PERSPECTIVES

Hunteria is a genus of plant in family Apocynaceae. It comprises of 12 species but more prevalent are Hunteria umbellata and Hunteria zeylanica. Taditionally H. umbellata have been used in the treatment of yaws and sexually transmitted infections, stomach ache, ulcers, diabetes mellitus and dysmenorrhoea. H. zeylanica is used to cure profile but its prolonged use, particularly, at high doses shoul...

Manpreet Kaur *and Rajmeet Singh

Department of Pharmaceutical Sciences (Pharmacognosy), G.H.G Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4367-73

4367-73

2377

737

8.

ZIKA VIRUS – A REVIEW ON PAST, PRESENT AND FUTURE SCENARIO

Zika virus is transmitted to people through aedes mosquito bites. People with Zika virus disease usually have symptoms of mild fever, exanthema (skin rash), joint pain and conjunctivitis that normally last for 2-7 days. There is no specific treatment or vaccine currently available. The best form of prevention is protection against mosquito bites. The virus is known to circulate in Africa, the Amer...

Eswara Rao G. *, K. Pallavi, Durga Nithya P. and Radha Madhavi B.

Vignan Pharmacy College, Vadlamudi, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4374-78

4374-78

2477

594

Research Articles

 
Title
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9.

CHARACTERIZATION AND ANTI-TUMOR ACTIVITY OF PEGYLATED NANOLIPOSOMES CONTAINING SAFRANAL IN MICE BEARING C26 COLON CARCINOMA

The cytotoxic effect of safranal, a pharmacologically active component of saffron, has been established in vitro. The aim of this study was to develop safranal nanoliposomes with a higher therapeutic index for the treatment of cancer. Thus, various PEGylated safranal nanoliposomes were prepared using HSPC and cholesterol by solvent evaporation. The liposomes were characterized by their size, in vi...

S. Abbaszadegan, H. Hosseinzadeh, S. H. Alavizadeh, M. Mohamadi, A. Abbasi and Md. R. Jaafari *

Biotechnology Research Center , Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: 10.13040/IJPSR.0975-8232.7(11).4379-86

4379-86

3096

1077

10.

QUANTUM AND HISTOLOGICAL STUDIES OF PARACETAMOL ALTERNATIVES TO AVOID CANCER EFFECT

Paracetamol (acetaminophen) (PA) is a widely used as an analgesic and antipyretic drug that is commonly available in without a prescription. Paracetamol has been used to treat many diseases such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It cures pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joints. It has been repor...

Anwar El-Shahawy *, Nesreen G. Abdelhaliem , Hana Gashlan and Safaa Qusti

Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(11).4387-99

4387-99

2949

971

11.

PROXIMATE ANALYSIS AND QUANTITATIVE ESTIMATION OF GALLIC ACID IN QUERCUS INFECTORIA OLIV. GALLS BY HPTLC

The galls of Quercus infectoria Oliv. (Family: Fagaceae) are commonly known as “Manjakani” by Malaysian community. It is one of the most popular traditional medicines used by the females to help regression of prolapsed uterus. The aim of this study was to perform the proximate analysis and quantitative estimation of gallic acid in the methanol extract of locally available galls of Q. infectori...

Gouri Kumar Dash*, Mohammed Tahir Ansari, Farheen Sami and Shahnaz Majeed

Universiti Kuala Lumpur Royal College of Medicine Perak, 30450 Ipoh, Malaysia

DOI: 10.13040/IJPSR.0975-8232.7(11).4400-06

4400-06

2980

813

12.

LYOPHILIZATION CYCLE COMPARISON AND SCALE-UP OF ESOMEPRAZOLE SODIUM FOR INJECTION BETWEEN LAB SCALE AND SCALE-UP BATCHES VS FDM STUDY

Lyophilization also known as freeze drying is a process in which water is removed from a product after it was frozen and placed under a vacuum, allowing the ice to change directly from solid to vapor without passing through a liquid phase. The process consists of three separate, unique, and interdependent processes; freezing, primary drying  (sublimation),  and  secondary  drying  (desorption...

Himankar Baishya*, Lin Shao Hui, Xu Xian Ping and Zhang Zibin

R & D, Beijing Sciecure Pharmaceuticals Co., Ltd., Beijing, China

DOI: 10.13040/IJPSR.0975-8232.7(11).4407-13

4407-13

4658

1310

13.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW PYRAZOLE DERIVATIVES

The synthesis of a novel of pyrazole derivatives was achieved by condensation of acetyl furan with phenyl hydrazine to give hydrazone (1) On the other hand, cyclization of α, β-unsaturated ketone. Using Vilsmeier reagent by DMF (dimethylformamid) and POCl3 Phosphorusoxychloride) to give compound (2). The chemical structures of allnew compounds were established by IR, ¹HNMR, and mass spectra dat...

Md A. Hamed, Ahmed A. El Gokha, R. Essam R. Abdelwahed, A. A. Mohamed , A. Moneim EL-Torgoman and Ibrahim El-Tantawy El Sayed *

Chemistry Department, Faculty of Science, El-Menoufeia University, Shebin El-Kom, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(11).4414-21

4414-21

3257

1043

14.

EVALUATION OF ANTIDIABETIC ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF CHRYSOPHYLLUM CAINITO FRUITS

Anti-diabetic activity of hydro-alcoholic extract of Chrysophyllum cainito frutis (CCE) was investigated against experimentally induced diabetics in rats using alloxan and streptozotocin (STZ). Acute toxicity study was performed and hydro-alcoholic extract of CCE was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg and 400 mg/kg b.w p.o. of the CCE were subjected for the ev...

Karunakar Hegde *, AP Arathi and Anupama Mathew

Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4422-28

4422-28

2815

656

15.

SYNERGISTIC ANTIBACTERIAL EFFECT OF SOME INDIAN MEDICINAL PLANTS AND COW (BOS INDICUS) URINE DISTILLATE AGAINST SELECTIVE PATHOGENIC GRAM-POSITIVE BACTERIA

Pathogenic bacterial infections are of serious clinical concern around the world. Indiscriminate use of antibiotics makes this situation beyond control. Hence, microbiologists are trying to find out the new and promising therapies against these bacterial infections. In the present research, combination therapy, which comprises extract of different medicinal plants and cow urine distillate, was use...

Vikas Pahal *, Arashdeep Kaur and Krishan Swaroop Dadhich

Department of Microbiology, Dolphin (P.G) College of Science and Agriculture, Chunni Kalan, F.G. Sahib, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4429-36

4429-36

1982

636

16.

GABA-AT INHIBITORY ACTIVITY OF BENZOTHIAZOLE – GABA ANALOGS: IN-SILICO APPROACH FOR ANTIEPILEPTIC PROFILE

Estimation of binding affinity of receptor – ligand complex in docking study of small molecules plays an Important role in structure based drug development process. The γ-amino-butyric acid amino-transferase (GABA-AT) exhibits a catalytic role in regulating γ-amino -butyric acid (GABA) level in brain and responsible for many physiological and pathological changes.  Here, in – silico study o...

J. Gagoria * and P. K. Verma

Pharmaceutical Chemistry Division, Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4437-42

4437-42

1752

548

17.

DEVELOPMENT AND VALIDATION OF A RP HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRINE AND CLOPIDOGREL IN COMBINED TABLET DOSAGE FORM

In this present study a novel, simple, economical, accurate and precise RP-HPLC method has been developed and validated for simultaneous estimation of aspirine and clopidogrel in combined tablet dosage form. Chromatographic separation was carried out on a Kromasil HD C18 (150 x 4.6 mm, 5µm) column with a mixture of acetonitrile and 0.1% (v/v) orthophosphoric acid aqueous solution in a ratio of 40...

Abdullah Al Masud * and Iris Begum

Department of Pharmacy, Jagannath University, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(11).4443-48

4443-48

3112

651

18.

A CASE CONTROL STUDY OF OXIDATIVE STRESS IN TUNISIAN PATIENTS WITH ISCHEMIC HEART DISEASE

Ischemic heart disease (IHD) is the major cause of morbid-mortality in most countries. The involvement of oxidative stress (OS) in the development of atherosclerosis, ischemic cardiopathy triggering phenomen, has been investigated. Serum total homocysteine (Hcy) concentration was measured by fluorescence polarization immunoessay. Plasma levels of substances reacting with thiobarbituric acid (TBARS...

S. Khelil *, M. Ben-Hadj-Mohamed , L. Khlifi, M. Ben Dbibis, H. Chahed, S. Ferchichi, S. Ernez and A. Miled

Biochemistry Laboratory, Farhat Hached hospital, Sousse, Tunisia

DOI: 10.13040/IJPSR.0975-8232.7(11).4449-55

4449-55

1866

672

19.

PHARMACOKINETIC DERIVATION OF RATES AND ORDERS OF REACTIONS IN MULTI-COMPARTMENT MODEL USING MATLAB

Pharmacokinetic modeling is the representation of the logarithmic mathematical equations in order to measure the physiologic response of the body to the drug. Absorption, distribution, metabolism and excretion follow drug kinetic principles according to specific reaction mechanisms in which concentration of the drug may either be dependent or independent of drug-body interactions. Michaelis-Menten...

Z. M. Llarena

Gokongwei College of Engineering, De La Salle University Manila Manila, Philippines.

DOI: 10.13040/IJPSR.0975-8232.7(11).4456-60

4456-60

2599

617

20.

SYNERGISTIC EFFECT OF HONEY WITH FOOD ADDITIVES AS ANTIMICROBIALS AND ON WEIGHT LOSS AND VARIOUS PHYSIOLOGICAL STUDIES IN MICE

The preliminary phytochemical evaluation and effect of Honey on Hematological parameters were investigated. Preliminary phytochemical screening was carried out to determine the presence of various bioactive constituents through different Tests. The Antimicrobial study of different Honey in combination with synergistics was carried out on selective microorganisms through well diffusion method. The ...

Khawla Juma Al Saadi, Awatef Khalifa Al Shaqsi and S Hemadri Reddy *

Graduate students, Biology section, Department of Applied Sciences, Higher College of Technology, Muscat,Sultanate of Oman.

DOI: 10.13040/IJPSR.0975-8232.7(11).4461-66

4461-66

2270

560

21.

DETECTION OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF MANGIFERA INDICA USING TLC BIO-AUTOGRAPHY

Mangifera indica is commonly found in India, which contains exalted medicinal values. TLC bioautography help us to identify the bioactivity of separated molecules in less time. In this study, leaves of Mangifera indica was subjected for various solvent extraction, followed with phytochemical screening and TLC bioautography for antioxidant and antibacterial activity. Column fractionation was done f...

Antony V. Samrot *, Bennet Rohan, Divya Kumar, K. Sahiti, P. Raji and Sree Samanvitha K.

Department of Biotechnology, Sathyabama University, Jeppiaar Nagar, Sholinganallur, Chennai, Tamil Nadu India

DOI: 10.13040/IJPSR.0975-8232.7(11).4467-72

4467-72

2820

860

22.

CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITIES OF BLACK SEED OIL (NIGELLA SATIVA L.)

Nigella sativa L. is an annual herb and cultivated largely in the East Mediterranean region. Seeds used in traditional folk medicine for the treatment of various purposes in the systems of Unani, Ayurveda, Chinese and Arabic. Nigella sativa seed oil was isolated using soxhlet hexane extraction process. GC-MS analysis identified a total of 32 compounds among which 9-eicosyne (63.04%), linoleic acid...

S. Dinagaran, S. Sridhar * and P. Eganathan

Department of Botany, Government Arts College, Tiruvannamalai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4473-79

4473-79

13238

1042

23.

INFLUENCE OF FLUCONAZOLE PRE-TREATMENT ON ANTIDIABETIC ACTIVITY OF THIAZOLIDINEDIONES IN DIABETIC RATS

The influence of fluconazole pre-treatment on the hypoglycaemic effect of pioglitazone (10 mg/kg, p.o) and rosiglitazone (720µg/kg, p.o) was studied. This study was conducted on diabetic rats of either sex, randomly distributed into two different groups. Diabetes was induced by administering 120mg/kg of alloxan intraperitonially. Then they were pretreated with fluconazole (36 mg/kg) in 2% w/v gum...

A. K. Patel *, J. Kaur, D. K. Yadav, M. Hasan and P. K. Tyagi

College of Pharmacy, Shree Ganpati Institute of Technology, Hapur, UP, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4480-84

4480-84

1715

642

24.

DESIGN AND IN VITRO EVALUATION OF PROCHLORPERAZINE MALEATE BUCCOADHESIVE TABLETS AND COMPARISON OF MONOLAYER, BILAYER AND COMPRESSED COATED TABLETS

Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Prochlorperazine maleate is an anti-emetic drug. It was under goes extensive first pass metabolism resulting in an oral bioavailability of 0 to 16 % and it shows variable absorption from GIT. Hence in the present work Buccoadhesive bilayered tablets of Prochlo...

S. Vijay Kumar *, Shaik Md. Zakir Hussain and C. Bharath

Department of Pharmacognosy, Sri Krishna Chaitanya College of Pharmacy (SKCP) Madanapalle-517325. Chittur dist. Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4485-93

4485-93

2395

687

25.

NEUROPROTECTIVE AND ANTIOXIDANT ROLE OF PREGABALIN IN STREPTOZOTOCIN INDUCED NEUROTOXICITY

Streptozotocin (STZ) induced neurotoxicity causes development of diabetic neuropathy in rodent models and oxidative stress is the main culprit in development of diabetic neuropathy. In the present study we aimed to evaluate the neuroprotective and antioxidant role of Pregabalin in STZ induced neurotoxicity. After 8 weeks, STZ induced diabetic rats showed sciatic nerve damage which was evident from...

Archana Jorige * and Akula Annapurna

RBVRR Women’s College of Pharmacy (Affiliated to Osmania University), Barktpura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4494-00

4494-00

2622

609

26.

CURATIVE EFFECTS OF MALOTILATE ON ETHANOL – INDUCED HEPATIC DYSFUNCTION IN RATS

In chronic alcoholics, continuous heavy drinking leads to progression of alcoholic liver disease (ALD) from alcoholic fatty liver, hepatitis to cirrhosis. Strict abstinence from alcohol has its own limitations and there is paucity of promising drugs available to treat ALD. Malotilate showed promising hepatocyte regenerating capacity and ability to prevent such damage. Aims:  The objective of this...

Kanchan Dnyanesh Borole * and Subhash Laxmanrao Bodhankar

Department of Pharmacology 1, Bharati Vidyapeeth Deemed University Medical, College, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4501-09

4501-09

2148

470

27.

EVALUATION OF ANTI-DIABETIC AND HEAPATOPROTECTIVITY OF CORIANDRUM SATIVUM IN ALLOXAN INDUCED EXPERIMENTAL ANIMALS: A HISTOPATHOLOGY STUDY

Objective: Diabetes mellitus is metabolic disorder and day by day number of people increased across the world. The aim of the present study was to evaluate the antidiabetic and heapatoprotectivity of ethanolic extracts of Coriandrum sativum in alloxan induced diabetic rat and find out the harmonious activity of the extract. Methods: The alloxan (150 mg/kg, i.p) used for induction of diabetes after...

B. Sharma, S. C. Joshi, N. Dut Jasuja, S. K. Singh and Gaurav Sharma*

School of Science 1, Suresh Gyan Vihar University, Jagatpura, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4510-15

4510-15

2070

619

28.

EVALUATION OF ANTICANCER EFFECT OF BRASSICA RAPA CHINENSIS LINN. USING IN VIVO MODEL

Aim: Dalton’s Lymphoma Ascites cells (DLA) are a cancer of the lymphocytes, a type of cell that forms part of the immune system. The present study aims to evaluate the anticancer effect of methanolic extract of bokchoy (Brassica rapa Chinensis leaves) using in vivo model in mice. Methods: The experimental mice were divided to 5 groups. The methanolic extract (800 mg/kg) and nanoparticles of meth...

Dharani Mayilsamy* and Kalaivani Krishnaswamy

Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4516-22

4516-4522

1994

950

29.

DEVELOPMENT AND VALIDATION OF A NOVEL STABILITY-INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF EMPAGLIFLOZIN IN BULK AND PHARMACEUTICAL DOSAGE FORM

A novel stability-indicative of RP-HPLC method was developed and validated for the quantitative estimation of Empagliflozin in bulk drugs and pharmaceutical dosage form in the presence of degradation products. Chromatographic separation was achieved on an Intersil C18 (150mmx4.6mm, 5 μm) analytical column using mobile phase composition of methanol and acetonitrile in ratio of (50: 50 v/v) that w...

N. Padmaja and G. Veerabhadram *

Department of Chemistry, University College of Technology, Osmaina University, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4523-30

4523-30

3959

999

30.

DEVELOPMENT OF VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF IRBESARTAN IN BULK AND PHARMACEUTICAL DOSAGE FORMS

A stability indicating RP-HPLC method was developed and validated for the determination of Irbesartan in bulk and dosage forms using Telmisartan (10 μg/ml) as the internal standard. An Inert ODS C-18, 5μm column having 250 x 4.6mm internal diameter in isocratic mode with mobile phase containing methanol: water (90:10) and the pH was adjusted to 3 with 1 % GAA. The flow rate was 1 ml/min and effl...

Kishanta Kumar Pradhan

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, MESRA, Ranchi, Jharkhand, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4531-39

4531-39

2032

629

31.

EVALUATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF SOME NUTRITIONAL SUPPLEMENTS

The nutritional supplements are the natural food supplements, and other related products used to boost the nutritional content of the diet. These nutritional supplements have been of interest to research because of their antioxidant property by consumption of food and drinks. The present study deals with a comparative evaluation of antioxidant and anti-inflammatory effects of marketed nutritional ...

P. Swetha*, Harish C. Rodda and T. Sandhya

Department of Pharmacognosy and Phytochemistry, Pathfinder Instituent of Pharmacy Education and Research, Opposite Warangal Airport, Mamnoor, Warangal, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4540-45

4540-45

1801

525

32.

ISOLATION AND PARTIAL CHARACTERIZATION OF PROTEASE FROM BACILLUS HALODURANS (AJ302709) FROM ALKALINE LONAR LAKE

Alkaline protease alone account for 60% of the total world enzyme market with its improved properties such as higher optimum temperature and alkaline pH. Alkaline Lonar Lake, situated in the Buldhana District of the Maharashtra State, India, is a unique ecosystem and harbors various haloalkaliphilic bacterial species which produces biotechnologically important thermo-haloalkaliphilic enzymes. The ...

D. H. Tambekar *, S. D. Tambekar, A. S. Jadhav and B. V. Babhulkar

Post Graduate Department of Microbiology, Sant Gadge Baba Amravati University, Amravati, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4546-49

4546-49

2105

865

33.

PRESCRIBING PATTERN OF ANTIDIABETIC DRUGS IN TYPE-2 DIABETIC PATIENTS

Diabetes is a rapid gaining status of potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the disease. Drug utilization studies are important for the optimization of drug therapy and have received a great attention in recent years. The study of drug utilization or prescribing patterns is a component of medical audit, which seeks monitoring, evaluatio...

N. Venkateswaramurthy *, Mohammed Shajeem S and R. Sambathkumar

J. K. K. Nattraja, College of Pharmacy, Kumarapalayam, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4550-55

4550-55

3515

940

34.

DYSMENORRHOEA: PREVALENCE, IMPACT AND KNOWLEDGE ASPECT OF TREATMENT IN FEMALES OF REPRODUCTIVE AGE IN TERTIARY CARE TEACHING HOSPITAL

Objectives: To describe the prevalence, severity, impact and treatment aspects of dysmenorrhoea in females of reproductive age group in tertiary care teaching hospital. Material and Methods: This was a questionnaire based survey type study. Detail information regarding demographic profile, menstrual history and dysmenorrhoea was   analysed.  Severity of dysmenorrhoea was evaluated by a Menstrua...

Parul A. Patel *, Bharti N. Karelia and Kiran G. Piparva

Pharmacology Department, P.D.U. Govt. Medical College, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4556-60

4556-60

2804

561

35.

ANTI TUBERULAR AND ANTHELMINTHIC ACTIVITIES OF AQUEOUS METHANOLIC EXTRACT OF CARALLUAMA ATTENUATA

Caralluma attenuata is a perennial small, leafless succulent plant which grows in tropical and subtropical areas. It belongs to the family Apocyanaceae.  The folkal information reveals that the tribes generally chew the whole plant to treat peptic ulcer, diabetes, in weight reduction to suppress hunger and also to produce endurance. It has been reported for the presence of steroids, flavanoids, s...

P. Mounika, M. Vijaya Jyothi *, P. Ramalingam, Vinusha Reddy J. and K. Anusha

Department of Pharmaceutical chemistry 1, Raghavendra Institute of Pharmaceutical Education &Research, Ananthapuramu, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4561-64

4561-64

1616

724

36.

ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE OF PRESCRIBING FIXED DOSE COMBINATIONS AMONG POSTGRADUATE MEDICAL STUDENTS – A CROSS SECTIONAL SURVEY

Objective: To evaluate the knowledge, attitude and practice, regarding Fixed Dose Combinations (FDCs) among Postgraduate medical students of Bangalore Medical College and Research Institute, Bengaluru. Materials and methods: The questionnaire based study was conducted among 150 Postgraduate medical students of BMCRI, Bengaluru. The data obtained was analyzed using descriptive statistics. Results: ...

Ankita Bedwal *, Aravinda V. and Kavitha Rajarathna

Department of Pharmacology, Bangalore Medical College and Research Institute, KR Road, Bengaluru, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4565-71

4565-71

1604

523

38.

ANTIDYSLIPIDEMIC AND ANTIOXIDANT ACTIVITY OF MEDICINAL PLANTS IN RAT MODEL OF HYPERLIPIDEMIA

The antidyslipidemic and antioxidant activities of Allium sativum (Garlic) and Aloe vera (Ghee- kuwar) extracts have been studied in two models of hyperlipidemia, triton and cholesterol rich high fat diet induced hyperlipidemia. A. sativum, A. vera and Gemfibrogil were macerated with 0.2% aqueous gum acacia and the suspension was fed orally to rats of group III, IV and V at a dose of 400mg, 1g/Kg,...

J. Neerja, P. Verma, V. Kumar *, F. Mahdi, A. Ali Mahdi, A. K. Khanna, J. K. Saxena and R. K. Singh

Department of Biochemistry, King George’s Medical University, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4579-87

4579-87

2268

677

39.

STUDIES ON ABOVE GROUND BIOMASS (AGB) FOR ASSESSING VEGETATION CARBON POOL IN TROPICAL FOREST ECOSYTEM OF CENTRAL INDIA

For estimation of carbon stocks in tropical forest types belonging to southern part of Madhya Pradesh, 30 adopted representative sites comprising eight districts viz, Jabalpur, Seoni, Balaghat, Narsinghpur, Mandla, Dindori, Shahdol and Umaria were selected for study and studies were carried out during 2009 to 2011. The study covered three types of vegetation i.e. teak mixed forest, sal mixed fores...

Hardayal Khangar * and D. K. Hirandhede

Department of Plant Physiology, Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur, MP, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4588-91

4588-91

1590

564

40.

FORMULATION AND CHARACTERIZATION OF DILTIAZEM HCL MATRIX TABLETS BY EMPLOYING ELECTROLYTES WITH GUM KONDAGOGU

The objective of the present investigation is to prepare and evaluate the sustained release matrix tablets of Diltiazem HCl using a natural polymer Gum kondagogu. Diltiazem HCl was formulated as sustained release matrix tablet formulations with natural polymer by employing pharmaceutically acceptable electrolytes. Electrolytes such as Sodium carbonate, Magnesium carbonate and Calcium carbonate wer...

B. Sudheer *, S. Vidyadhara , M.V. Basaveswara Rao, RLC. Sasidhar and K. Venkata Ramana

A. S. N. Pharmacy College, Tenali, A.P., India

DOI: 10.13040/IJPSR.0975-8232.7(11).4592-01

4592-01

2195

514

41.

STUDY OF ORAL HYPOGLYCEMIC ACTIVITY OF RHIZOMES OF HEMIDESMUS INDICUS R. Br. IN ALBINO WISTAR RATS

The present study was carried out to evaluate oral hypoglycemic activity of rhizome of Hemidesmus indicus R.Br. in Albino wistar rats. Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian Medicinal Plant. It contains various phytoconstituents like hemidesminine, hemidine, hemidesmin-1 and hemidesmin-2 and other chemical constituents like glycosides, flavonoids, tannins, sterols a...

Tabassum *, Mazumder Avijit and Das Saumya

Pharmacy Institute, NIET, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4602-07

4602-07

1687

595

42.

SCREENING OF PHYTOCHEMICAL AND IN-VITRO ANTIOXIDANT PROPERTY OF A POLYHERBAL FORMULATION

Herbal plants produce a diverse range of bioactive molecules, making them a rich source of different types of medicines. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. As such developing a polyherbal formulation will definitely produce synergistic effect as needed comparable to standard drugs that are available in market all over th...

P. Kavitha * and C. Sowmia

P. G. Department of Biochemistry, Dr. N.G.P. Arts and Science College, Coimbatore, TN, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4608-14

4608-14

2094

551

43.

EFFECT OF MEDICINAL PLANT EXTRACTS ON THE ANTIMICROBIAL ACTIVITY OF AMOXYCLAVE AND ERYTHROMYCIN AGAINST E. COLI AND S. AUREUS

Development of microbial resistance leads new drug discovery, modification of antibiotics, administration of two or more antibiotics, use of traditional medicinal plants and their combinations with antibiotics. In the present study, 72 medicinal plants extracts were screened to potentiate the antimicrobial with erythromycin and amoxyclave. Among all the medicinal plant, Colebrookea oppositifolia w...

Vipasha Sharma *, Tarun Kumar and Kamal Dev

Department of Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan Himanchal Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4615-25

4615-25

2432

647

44.

ANTIBIOTIC RESISTANCE PATTERNS AND EVALUATION OF TREATMENT IN OUT-PATIENTS WITH URINARY TRACT INFECTIONS IN NEPAL

The study was aimed to investigate the common causative agents of urinary tract infection in community, their resistance pattern to different antibiotics, and the prescribing patterns of antibiotics used for treatment. A total of 200 women attending gynaecology OPD of Tribhuvan University teaching hospital had their urine tested for culture and sensitivity, out of which 85 showed microbial growths...

Saroj Kumar Sah, Shobha Regmi, Anup Raj Upreti and Shiva Pathak *

Department of Pharmacy, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal

DOI: 10.13040/IJPSR.0975-8232.7(11).4626-31

4626-31

2533

655

45.

COMPARATIVE STUDY OF THE ESTIMATION OF LDL CHOLESTEROL BY THE DIRECT METHOD AND FRIEDEWALD EQUATION IN SECONDARY HYPERLIPIDEMIA

The objective of the study is to measure the difference between the levels of LDL by Direct method versus Friedewald equation. The study includes 30 patients and 30 controls in the age of 25 – 75 years of both sexes. Fasting blood samples were collected and estimated Total Cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL-C) cholesterol and High density lipoprotein (HDL) cholest...

T. Ilanchezhian *, R Vanaja and Balaji Rajagopalan

Department of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Ammapettai, Kancheepuram district, Taminadu, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4632-36

4632-36

2291

770

46.

IDENTIFICATION AND CHARACTERIZATION OF E, Z ISOMERS FOR ACID DEGRADENTS OF SECONDARY ALCOHOL IN API BY HS/GC/ EI-MS

2º alcohols under acidic conditions (such as sulphuric acid) undergo degradation into E & Z isomers. There are many drug substances with sulphate as salt, and sulphuric acid is used for the preparation of sulphate of drug substance. Also, sulphuric acid is widely used in synthetic process for many drug substances. 2º alcohols are widely used as process solvents and as crystallization solvent...

Kaviraj Yarbagi *, Nagaraju Rajana, J. Moses Babu, B. Venkateswara Rao and Paul Douglas

Analytical Research, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd., Miyapur, Hyderabad, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4637-43

4637-43

1710

539

47.

ANTI OBESITY ACTIVITY AND BENEFICIAL EFFECTS OF METHANOLIC EXTRACT OF DESMOSTACHYA BIPINNATA IN HFD AND PROGESTERONE INDUCED OBESITY IN RATS AND MICE

Obesity is very serious and concerned problem these days.  From the first human civilization, research is going to find the drugs to treat obesity and its complications. Despite availability of many drugs in market to treat obesity, no single drug is ideal for treating all sorts of problems caused by obesity. So the research is going on finding perfect drug. Prior going to evaluating drugs on hum...

M. Y. Deepika *, M. A. Rama Lakshmi Devi, B. Nagaraju, P. R. Deepthi and B. V. Bakshi

Department of Pharmacology, Anurag group of Institutions, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4644-55

4644-55

2314

787

48.

PHENYTOIN MONOTHERAPY IN EPILEPSY AND ITS EFFECT ON TSH

Long term administration of antiepileptic drugs has been found associated with development of hypothyroidism. But conflicting reports about effect on thyroid stimulating hormone (TSH) are available in literature and duration required to bring about this effect has also not been reported. Therefore, twenty five newly diagnosed adult patients with epilepsy were subjected to estimation of TSH before ...

K. Dahiya *, R. Kumar, A. Bansal, R. Dhankhar, V. S. Ghalaut, K. Chugh and S. Kumari

Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4656-59

4656-59

2438

438

49.

EFFECTS OF JUSSIAEA REPENS L ON SPERM DNA INTEGRITY IN MALE ALBINO RATS

Fertility control is an issue of global challenge. Researchers are trying to develop male herbal contraceptives from natural sources. Jussiaea repens L (JR) is such an herb which is reported to have non toxic antigonadal activity in male rats. The present study has designed to evaluate whether crude queous extract of JR affects the DNA integrity of spermatozoa and also to study whether its actions...

Subhasish Ghosal , Indrani Chakraborty and Nirmal Kr Pradhan *

Department of Physiology 1, Presidency University, Kolkata, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4660-68

4660-68

1596

561

50.

PHARMACOGNOSTIC, PHYTOCHEMICAL AND ANTIOXIDANT ACTIVITY STUDIES ON CORDIA OBLIQUA WILLD. LEAF

Cordia obliqua Willd. (Clammy Cherry) belongs to genus Cordia and family Boraginaceae. It possesses a number of traditionally mentioned medicinal activities like purgative, diuretic, antipyretic, anthelmintic, analgesic and hepatoprotective. The present work is related with Pharmacognostic, Phytochemical and antioxidant study of Cordia obliqua leaf. Under Pharmacognostic study various parameters l...

R. Gupta * and G. D. Gupta

Department of Pharmacognosy, ASBASJSM College of Pharmacy, Bela (Ropar) , affiliated to I. K. Gujral Punjab Technical University, Jallandhar, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4669-77

4669-77

2196

678

51.

GASTRORETENTIVE SUPERPOROUS HYDROGEL TABLETS OF DEXLANSOPRAZOLE

Superporous hydrogels (SPHs) were developed to retain the drug in the gastric medium. These systems swell very rapidly in the stomach and maintain their integrity for longer time even in the acidic environment of stomach, while releasing the pharmaceutical active ingredient. The present work focuses on concept of development of superporous hydrogel tablets of Dexlansoprazole, their comparativeness...

Nikunja B. Pati *, Swapna Velivela, Vinyas Mayasa and V. R. M. Gupta

Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram, Medak, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(11).4678-85

4678-85

2689

799

52.

EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF AERVA PSEUDOTOMENTOSA LEAVES AQUEOUS EXTRACT

Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae) is arid region plant commonly known as Bui. It is used in ethno medicinal practices for the treatment of pain and inflammatory hyperalgesic disorders such as rheumatic pain, fever, inflammation, wounds and urinary disorders. This study was conducted to evaluate the anti-nociceptive, antipyretic effects of A. pseudotomentosa leaves aqueous e...

Abhishek Pandey * and Atul Kaushik

School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India. Department of Pharmaceutical Sciences , IFTM University, Moradabad, Uttar Pradesh, India. IPS College of Pharmacy , Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4686-92

4686-92

1874

561

53.

OM NAMAH SHIVAYA CHANTING FOR MANAGEMENT OF STRESS IN ELDERLY WOMEN WITH HYPERTENSION

Stress is part and parcel of our life and stress management is gaining importance day by day. Traditional mantras are reported to be very effective for and safe methods. Hence the traditional knowledge of mantras should be practiced, preserved and propagated. Om Namah Shivaya is a most potent and popular mantra, which is at the heart of the Vedas and Tantra. The present study was aimed to observe ...

Priya P. Roy *, Kumar Sai Sailesh, Archana R, Soumya Mishra, Arati Amin, Sabu Thomas, Udaya Kumar Reddy and Supriya Rajan

Associate Professor, Department of Anatomy, Krishna institute of Medical Sciences. Malkapur, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(11).4693-96

4693-96

6009

929