Volume 12 (2021) - Issue 2, February
A CURRENT REVIEW FROM RECENT LITERATURE ON NOVEL SARS-COV-2 OUTBREAK
The outbreak of a novel coronavirus 2019 was traced back in China in late 2019, followed by their worldwide transmission as a pandemic. From January to August 2020, a total of 1,724 papers were published, where 125 were only published in August 2020, demonstrating the importance and need for current awareness and research to overcome this deleterious virus. This paper briefly highlighted the major...
IMMUNOSUPPRESSIVE ANTI-CANCER DRUGS MAY INCREASE COVID-19 INFECTION RISKS
There is a new public health crisis threatening the world with the emergence and spread of the 2019 novel coronavirus (2019-nCoV). Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which invades cells through the angiotensin-converting enzyme 2 (ACE2) receptor. SARS-CoV-2 shares 82% genome sequence similarity to SARS-CoV and 50% geno...
AN OVERVIEW OF PROMISING HERBAL MEDICINES FOR TREATMENT OF PSORIASIS
Psoriasis is a skin disorder marked with inflammation. The development and progression of the disease are associated with a chronic inflammatory response, which is attributed to the dysregulated innate immune system. The dendritic cells and T cells secrete various cytokines leading to disturbances in the keratinocyte proliferation and differentiation. Several medications are available for the m...
AN UPDATE ON BIOLEACHING TECHNOLOGY: IRON BACTERIA AS A SOURCE OF OXIDIZING IRON TRACES FROM WATER SAMPLES
The removal of metals by the use of microbes is known as bioleaching in terms of oxidation or degradation of metal from complex raw materials or depots. Such microbial oxidation or bio-removal occurs in terms of sulphur degradation and oxidation (for example, sulphur oxidation, iron oxidation etc.). This process is thus known as bioleaching, which is related to the all metal oxidation processes li...
OZONE THERAPY: A PARADOX OR PANACEA IN VARIOUS AILMENTS
Ozone gas (O3), being an unstable molecule, attracts uncertainty as an alternative to medication, opening avenues for copious research. Ozone therapy (OT) shows its therapeutic efficacy by its reactions with biological components and the production of oxidative stress. It is found useful in various disease conditions like cancer, cardiovascular diseases, pulmonary diseases, wound healing, dental c...
A REVIEW ON WOUND AND ADVANCEMENT IN HEALING STRATEGIES
Wound healing is a complex and dynamic physiological process that occurs by a sequence of interrelated molecular events that should work together in a proper manner and time to restore cellular function and tissue integrity. These physiological phases occur efficiently in normal healthy volunteers and/or under normal conditions. But, in some cases, these events are retarded, which results in hard-...
IN-SILICO STUDY: COX2 (CYCLO-OXYGENASE 2), AN UNKNOWN TARGET OF HYDROXYCHLOROQUINE REPOSITIONED FOR THE TREATMENT OF COVID 19 INFECTION AND CARDIOVASCULAR EFFECTS
Hydroxychloroquine, widely used to treat certain autoimmune diseases and inflammatory conditions, has been repositioned as a new lead against the COVID-19 pandemic. Preliminary studies have suggested that hydroxychloroquine inhibits the entry of the SARS-CoV2 virus mediated by the ACE2 receptor and is a particularly interesting anti-inflammatory and immunomodulatory action in the cytokine storm du...
COMPARATIVE STUDY OF THE EFFECTS OF LAURUS NOBILIS AND SYZYGIUM AROMATICUM AQUEOUS EXTRACTS ON URINE VOLUME AND RENAL FUNCTION IN RATS
The purpose of the current study was to investigate the diuretic and renal effect of the aqueous extracts of Laurus nobilis leaves and dried flower buds of Syzygium aromaticum. Four groups of rats were used. Group 1 received distilled water (10 ml/kg BW), group 2 received the aqueous extract of Laurus nobilis (300 mg/kg BW), group 3 received the aqueous extract of Syzygium aromaticum (300 mg/kg BW...
ANTIOXIDANT PECTIN FROM CACTUS OPUNTIA DILLENII GROWING IN NINH THUAN COAST, VIETNAM: EXTRACTION, PHYSIC-CHEMISTRY CHARACTERIZATION AND ANTIOXIDANT ACTIVITY
The extraction condition, physic-chemistry characterization, and antioxidant activity of pectin from cactus Opuntia dillenii found commonly growing in the Ninh Thuan coast, Vietnam, were studied. The extraction conditions of antioxidant pectin content, such as temperature, time, cactus-to-solvent ratio, solvent pH, and extraction numbers, were surveyed. A correlation between pectin content and ant...
CHARACTERIZATION AND IDENTIFICATION OF ACTIVE COMPOUND OF OCELLATED SNAKEHEAD (CHANNA PLEUROPHTHALMUS BLKR) WASTE CHARCOAL POTENTIAL AS ANTIALLERGY DRUG
Natural resources potentials, such as animals or plants, have been utilized as a traditional herb and can be benefitted for human health and to support the government program in medication to be back to nature. The body parts often used for the traditional drug are meat, horn, tail, feather, nail, fat, bile, and shell. The animal's potential to develop as medicine meets the following criteria: eas...
LIQUISOLID TABLET: AN EFFECTIVE APPROACH TOWARDS IMPROVEMENT OF DISSOLUTION RATE OF FAMOTIDINE AS POORLY SOLUBLE DRUGS
This paper examined the liquisolid compact method as one of the tools for greater dissolution of the practically water-insoluble drug famotidine (FM). Therefore, the model drug, FM, has been formulated as directly compacted tablets and liquisolid compacts and then investigated for in-vitro release properties at diverse dissolution circumstances. According to the method, it is possible to convert t...
ADSORPTION KINETICS OF THE REMOVAL OF CIPROFLOXACIN FROM PHARMACEUTICAL WASTEWATER BY SURFACTANT MODIFIED KAOLINITE
In recent years, the extensive use of antibiotics has resulted in their frequent detection in the effluent discharge of wastewater discharge plants (WWTPs). In this study, the feasibility of using Surfactant-Modified Kaolinite (SMK) to remove the antibiotic, Ciprofloxacin (CIP) from wastewater was evaluated from batch experiments. The batch adsorption system was utilized to evaluate the CIP remova...
FORMULATION DEVELOPMENT AND EVALUATION OF FLOATING BIOADHESIVE TABLET OF ANTIRETROVIRAL DRUG
Oral route has been commonly adopted and the most convenient route for drug administration. It has been received more attention in the pharmaceutical field because of the more flexibility in the designing of dosage form than drug delivery design for other routes. Gastroretensive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of...
FORMULATION OF DORZOLAMIDE HYDROCHLORIDE IN-SITU PREPARATION FOR TREATMENT OF GLAUCOMA; IN-VITRO, EX-VIVO AND IN-VIVO CHARACTERIZATION
Present study was planned to prepare a dorzolamide hydrochloride in-situ gel by using Carbopol 974 and HPMC K4M to reduce dosing frequency by increasing residence time as well as sustained drug release from the formulation in cul-de-sac. The concentration of both polymers was optimized by using 32 factorial designs with correlating its impact on dependent variables as cumulative in-vitro drug diff...
A RAPID SPECTROPHOTOMETRIC DETERMINATION OF NI(II) IN MEDICINAL PLANT MATERIALS AND WATER SAMPLES USING N’,N”’-((1E,1’E)-(PROPANE-1,3-DIYLBIS (SULFANEDIYL)) BIS(1-(4-BROMOPHENYL) ETHAN-2-YL-1-YLIDENE)) BIS(2-HYDROXYBENZOHYDRAZIDE) AS A SELECTIVE AND SENSITIVE ANALYTICAL REAGENT
N',N'''-((1E,1'E)-(propane-1,3-diylbis (sulfanediyl)) bis (1-(4-bromophenyl) ethan-2- yl-1-ylidene)) bis (2-hydroxybenzohydrazide) (BAPSSHZ) is found to be a selective and sensitive analytical reagent for the determination of trace levels of nickel (II) in environmental samples like medicinal plant materials and water samples (potable and polluted) by spectro-photometry. BAPSSHZ reacts with Ni (II...
POLYPHENOLS AS ADJUVANT IN TOSSING OUT ACNE VULGARIS (PUSTULES): A NOVEL FORMULATION STRATEGY
Acne vulgaris is a skin condition in which people lose their self-esteem and ultimately lead to depression. It is more common among the adolescent age groups. According to GBD (Global burden of disease) study, about 85% of the populations are being affected. Various medications are available for the treatment, but, its uses are limited due to side effects like skin irritation. In our study, we hav...
PHYTOCHEMICAL INVESTIGATION AND IN-VITRO ANTIMICROBIAL ACTIVITY OF THE ESSENTIAL OIL FROM RHIZOMES OF HEDYCHIUM SPICATUM
The chemical configuration and antimicrobial activity of Hedychium spicatum rhizome based essential oil was studied, which is also commonly known as Kapoorkachri, grown grown wildlyacross Karnataka Karnataka, India. Thirty-eight compounds were detected from the rhizome based essential oil by GCMS. The main compound was characterized as Ethyl p-methoxy-cinnamate (50.1%), Ethyl cinnamate (26.22%), a...
A VALIDATED STABILITY INDICATING RP-HPLC METHOD OF ESTIMATION OF PIOGLITAZONE HCL IN DOSAGE FORM
This present study aims to develop an accurate, precise, and linear reverse-phase High-Performance Liquid Chromatographic (RP-HPLC) method for the estimation of Pioglitazone HCL in Pharmaceutical dosage form. Method: The chromatographic system employs a reverse-phase Hypersil BDS, C8 250 × 4.6 mm, 5 columns using 0.01M Potassium phosphate buffer and acetonitrile (40:60) as mobile phase, methanol ...
EFFECT OF DICHLOROMETHANE EXTRACT OF ALSTONIA SCHOLARIS LEAVES IN DIFFERENT MODELS OF DIABETIC NEPHROPATHY IN RATS
Aim: The main of the study is to study the Effect of Various Polar & Non-Polar Extracts of Alstonia scholaris leaves in Different Models of Diabetic Nephropathy in Rats. Material & Methods: Leaves of selected plant was extracted by using various solvents, i.e., Pet ether, Dichloromethane, Ethyl acetate, methanol and water. All the extracts were screened for the presence of various active p...
TRENDING MICROBIOLOGICALS AND THEIR ROLE TO ENHANCE GROWTH AND ESSENTIAL OIL CONTENT OF DILL (ANETHUM GRAVEOLENS)
A greenhouse and field experiment was conducted to investigate the effects of Azotobacter (Azotobacter chroococcum), Phosphate solubilizing bacteria (Pseudomonas fluorescens), and Arbuscular mycorrhiza-like fungi (Sebacinca vermifera) on seed germination, physiology, and essential oil production of dill (Anethum graveolens). The experimentation was comprised of a randomized complete block design w...
OPTIMIZATION OF ANALYTICAL METHOD FOR QUANTIFICATION OF 5-METHOXYCANTHIN-6-ONE BY FACTORIAL DESIGN AND PRELIMINARY STABILITY TEST
Studies of natural products emerge as an important medicinal resource. An example is the use of Zanthoxylum chiloperone (Rutaceae) for medicinal purposes against neglected diseases, as for example, Chagas disease and leishmaniasis. The analysis of the chemical composition of this medicinal plant was carried out by chromatrographic techniques to evaluate its pharmacological applications. The use of...
FORMULATION DEVELOPMENT AND OPTIMIZATION OF HERBAL IMMEDIATE RELEASE TABLET FOR DENGUE
Dengue is the most rapidly spreading mosquito-borne viral disease in the world. Patients with dengue fever are treated symptomatically. There is no specific allopathic treatment for dengue fever. Traditional medicinal plants have been reported to be useful in the treatment of dengue fever. The development of new anti-dengue products from bioactive compounds is necessary to find an effective treatm...
EVALUATION OF ANTIMICROBIAL ACTIVITY OF SESUVIUM PORTULACASTRUM (L.) L. AND EXCOECARIA AGALLOCHA L.
Background: Sesuvium portulacastrum L. and Excoecaria agallocha (L.) are two important medicinal plants inhabited in mangrove regions. Early researches focused on antimicrobial activity of leaves of concerned plants with various solvents among which ethanol, chloroform, and methanol were the best Objective: In the present study the extracts of two therapeutic plants were researched to measure the ...
SYNTHESIS AND CHARACTERIZATION OF NOVEL PYRIMIDINE-4,5-DIAMINE/ PYRIMIDINE-2,4,5-TRIAMINE AS ANTITB AGENT
Pyrimidine derivative had a wide range of biological activities, including antiTB activity. In this view, pyrimidine moiety containing N N5-(3-substituted benzylidene)-N4-phenyl and N5-(2-substituted benzylidene)-N2,N2-dimethyl-N4-phenyl compounds was designed, and a novel series of N5-(3-substituted benzylidene)-N4-phenyl pyrimidine-4,5-diamine [5A-5F]/N5-(2-substituted benzylidene)-N2,N2-dimethy...
DEVELOPMENT AND EVALUATION OF PHOSPHATIDYLCHOLINE COMPLEXES OF ARBUTIN AS SKIN WHITENING AGENT
Introduction: Disorders of hyperpigmentation are difficult to treat, particularly in dark skin individuals. There is a dramatic enhancement of skin permeability of phytoconstituents due to their complexation with phospholipids. Complexation leads to better permeation through the skin, which is otherwise not possible. Research work focused on the development and evaluation of phos-phatidylcholine c...
IN-VITRO ANTIFUNGAL STUDY OF FILTRATES OBTAINED FROM SOME MARINE FUNGI AGAINST SOME DERMATOPHYTES AND YEASTS
Many infectious diseases have been treated with natural medicine. Now, fungi metabolites continue to play a major role as a therapeutic medicine in many countries. The present study reveals the potentiality of filtrate of Aspergillus terreus and Cladosporium cladosporioides as antidermatophitic agents. Molecular identification of isolates fungi using DNA sequencing of EF4 and ITS4primerswere perfo...
DEVELOPMENT AND VALIDATION OF DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF DULOXETINE
Development and validation of a simple UV spectroscopic method for the determination of Duloxetine by the derivative spectro-photometric method is the objective of the present work. The analysis was carried out by using Shimadzu UV-1700, and Shimadzu UV-1800 UV spectrophotometer, and Acetonitrile and water (8:2) was used as solvent or mobile phase. Detection or qualitative analysis was carried out...
NEUROPROTECTIVE ACTIVITY OF SOLASODINE FROM SOLANUM XANTHOCARPUM FRUITS AGAINST CEREBRAL ISCHEMIA/REPERFUSION – INDUCED OXIDATIVE STRESS IN RAT
Ethnopharmacological Relevance: Traditional herb Solanum xanthocarpum contains solasodine as the chief constituent of fruits. Since analgesic, anti-inflammatory, anticonvulsant effects of fruits are reported; study was designed to rationalize the use of solasodine as neuro-protective with its mechanism of action. Aim of Study: Cerebrovascular Diseases (CVD) includes devastating disorders like isch...
IN-VITRO ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF YEMENI PLANTS MYRTUS COMMUNIS L. AND FLEMINGIA GRAHAMIANA WIGHT & ARN.
Yemen is located on the southwestern brink of the Arabian Peninsula. The methanolic and aqueous crude extracts of two Yemeni traditional medicinal plants Myrtus communis L. and Flemingia grahamiana Wight & Arn were evaluated for antibacterial activity in-vitro by Well- diffusion method against six bacterial pathogens, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella...
INDOLE 1,2,3,4-TETRAHYDROPYRIMIDINONE: SYNTHESIS, CHARACTERIZATION AND IT’S BIOLOGICAL APPLICATIONS
The present research work involves the use of exclusively and commercially available indole-3-carbaldehyde as a starting material to synthesize novel pyrimidine analogues. The synthesis of series of indole and pyrimidine containing N-substituted-4-(1H-indol-3-yl)-6-methyl-2-oxo-1, 2, 3, 4-tetrahydro-pyrimidine-5-carbohydrazide U(1-10) has been done by using principle of Biginelli condensation reac...
ESTIMATION OF DACLATASVIR IN PHARMACEUTICAL DOSAGE FORM BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY
Daclatasvir is an antiviral drug used in combination with other drugs includes sofosbuvir, ribavirin, and interferon, depending on the virus type to treat cirrhosis caused by hepatitis C (HCV). Several methods have been found for quantification, but those are not cost-effective, and they are time-consuming. The present study developed a simple, precise, accurate and cost-effective UPLC method to d...
EVALUATION OF CORRELATION FACTORS FOR PREVALENCE OF ANEMIA AND UTILIZATION OF HEMATINICS AMONG PREGNANT AND LACTATING WOMEN
Anemia is defined as a decreased hemoglobin level or circulating red blood cells, and it is the most common hematological disorder during pregnancy. The study was aimed to review the prevalence of anemia in pregnant and lactating women and to find out the correlation between educational status and prevalence of anemia if any. A Concurrent Observational study was carried out Using a Case Sheet of t...
EFFECT OF GARLIC AND GINGER AQUEOUS EXTRACT ON MITOTIC INDEX OF ONION ROOT TIPS GROWN IN PESTICIDE CONTAINING WATER
Since ancient times, herbal knowledge has been used in the field of health care by different cultures. Ginger and garlic are important herbs that have covered a wide role in various health ailments like kidney and heart diseases. Also, they are considered to be potential against suppressing toxicity. The present study was conducted to evaluate the toxicity suppressing capability of these two herbs...
IN-VITRO ANTIUROLITHIATIC POTENTIAL OF LEAVES OF EUPHORBIA HIRTA L. AGAINST CALCIUM OXALATE KIDNEY STONES
Plant Euphorbia hirta L. is a common weed plant that belongs to the family Euphorbiaceae characterized by the presence of milky latex in leaves and stems. Phytochemical screening of leaves of Euphorbia hirta L. confirmed the presence of alkaloids, cardiac glycosides, flavonoids, phenolic compounds, tannin and terpenoids. FT-IR confirms the formation of calcium oxalate crystals with major peaks at ...
FORMULATION, DEVELOPMENT AND OPTIMIZATION OF CONTROLLED POROSITY OSMOTIC PUMP TABLETS OF TRAMADOL HYDROCHLORIDE
The aim of the present study was the formulation, development, and optimization of controlled porosity osmotic pump tablets of Tramadol hydrochloride. Cellulose acetate was used as the semi-permeable membrane. The porous osmotic pump contains pore-forming water-soluble additive (PEG-8000) in the coating membrane, which after coming in contact with water, dissolves, resulting in an in-situ formatio...
THE ANTIOXIDANT EFFECTS OF IPB-3S STRAIN ORYZA SATIVA BRAN EXTRACT TOWARDS MALONDIALDEHYDE AND GLUTATHIONE PEROXIDASE LEVELS IN RAT BRAIN INDUCED BY CARBON TETRACHLORIDE
IPB-3S Strain Oryza sativa bran, a high-antioxidant food, was expected to protect the brain as a susceptible organ from oxidative damage. This study was conducted to analyze the effect of rice bran extract on malondialdehyde (MDA) and glutathione peroxidase (GSH) levels in the brain induced by carbon tetrachloride (CCl4). A total of 24 Sprague-Dawley male rats was divided into 6 groups, including ...
SYNTHESIS AND CHARACTERIZATION OF BENZOCAINE SCHIFF BASE AND ITS COBALT COMPLEX
Ethyl4-(2-hydroxy-benzylideneamino) benzoate Schiff base (C16H15NO3), were synthesized and the structure was studied against the bases of X-ray, UV, visible, elemental analysis, 1HNMR, IR and Mass spectroscopy. The crystal structure of the nickel complex has been determined by single crystal X-ray conformed the molecule, which indicate the compound is crystalline in the monoclinic C2 / c with a = ...
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL 2, 3-DIHYDRO-1, 5-BENZOTHIAZEPINE DERIVATIVES
In the present investigation, a series of some novel 4-[substituted-2-hydroxy-phenyl]-2-(4′-dimethylamino-phenyl)-2, 3-dihydro-1, 5-benzothizepines (2a-l) have been synthesized by the treatment of 1-(substituted-2-hydroxy-phenyl)-3-(4′-dimethylamino-phenyl)-prop-2-en-1-ones (chalcones) (1a-l) with 2-aminothiophenol using ethanol as a solvent in the presence of catalytic amount of Lanthanum Nit...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LORNOXICAM AND THIOCOLCHICOSIDE IN BULK FORM AND MARKETED PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC
A simple, reproducible, and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of Lornoxicam and Thiocolchicoside in pure form and marketed combined pharmaceutical dosage forms. A column having Symmetry (C18) (150mm × 4.6mm, 5µm) in isocratic mode with mobile phase containing Methanol: Phosphate Buffer (pH-3.8) (28:72 v/v) was used...
HUMAN AChE SELECTIVE INHIBITION OF PHYTOCHEMICALS OF SONCHUS WIGHTIANUS OF NEPAL ORIGIN: AN IN-SILICO APPROACH
Background: Alzheimer's disease (AD) is the most common type of dementia, which represents one of the major difficult challenges for drug discovery. Currently, 62% of the people are suffering from Alzheimer's disease around the world is expected to reaching 131.5 million people, and this will reach 71% by 2050. So far, only five drugs have been registered for the treatment of AD, including four ac...
IN-VITRO ANTICANCER POTENTIAL OF CHLOROFORM EXTRACT OF LEAVES OF THULASI VETTILA- A CULTIVAR OF PIPER BETLE L. IN KERALA
The present study was designed to evaluate the anticancer potential as well as cytotoxity of Chloroform extract of Thulasivettilacv of Piper betle L. is an evergreen perennial creeper belonging to family Piperaceae, and known to possess numerous medicinal properties. Current study focuses on evaluating antiproliferative potentialities of Betel leaves. The antiproliferative effect was tested agains...
METHOD DEVELOPMENT AND FORMULATING REBAMIPIDE SUSTAINED RELEASE TABLETS AND ITS EVALUATION
Last few eras, the remarkable advancement in the drug delivery system has been done; the oral route remains the important and picks up the safest route of drug delivery. Regardless of outstanding advancements in the oral route medication, the current study focused on the formulation of rebamipide SR tablets by studying several blends and their characteristics, including drug-excipients compatibili...
ANTIDIABETIC ACTIVITY OF AVICENNIA ALBA IN STREPTOZOTOCIN INDUCED TYPE-2 DIABETIC RATS
The study was initiated to determine the antidaibetic activity of Avicennia alba in Streptozotocin induced Type-2 diabetic rats. The rats were treated with 100, 200 and 400 mg/kg of Avicennia alba stem and leaf methanolic extract (MLAA) and compared with the diabetic, normal and standard (glibenclamide) rat groups. The blood glucose levels, glycosylated haemoglobin levels, and body weight of the r...
DEVELOPMENT AND CHARACTERIZATION OF MICROSPONGE GEL FOR TOPICAL DELIVERY OF OREGANO OIL
Oregano oil is an essential oil possessing anti-inflammatory, antioxidant, antimicrobial, and immune-boosting properties that can be used in the treatment of various skin disorders. However, its practical applications are limited due to its handling issues and poor stability in the presence of air, light, and high temperature. To overcome these problems, this study aims to entrap oregano essential...
PROTECTIVE EFFECT OF CINNAMOMUM ZEYLANICUM BARK AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY IN ALBINO RATS
The objective of the current study is to investigate the hepatoprotective activity of Cinnamomum zeylanicum bark (CZB) extract on acetaminophen-induced hepatotoxicity in albino rats. Wistar albino rats (150-200 g) of either sex were divided into six groups, and toxicity was induced by acetaminophen (APAP) at a dose of 750 mg/kg, bw, p.o, every 72 h, for two weeks. Silymarin (100 mg/kg, p.o) was gi...
FORMULATION AND EVALUATION OF SAGO STARCH FILM CONTAINING LEVOCETIRIZINE DIHYDROCHLORIDE
Levocetirizine dihydrochloride is an orally active, third-generation non-sedative antihistamine used in the symptomatic relief of seasonal and perennial allergic rhinitis. It competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. The present work aimed to prepare mucoadhesive buccal films to deliver the drug in a controlled manner with a longer...
ENHANCEMENT OF SOLUBILITY OF AN ORAL HYPOGLYCAEMIC DRUG, GLIMEPERIDE BY THE TECHNIQUE COCRYSTALLISATION
Co-crystallization is one of the most reliable alternative approaches to increase the solubility of poorly water-soluble drugs without affecting their physicochemical properties. Pharmaceutical cocrystals are neutral organic compounds connected to the API preferentially by loosely formed bonds as dipole-dipole interaction. Our present study aims at improving the solubility of an effective oral hyp...
TO COMPARE THE EFFECTS OF DEXMEDETOMIDINE (WITHOUT BOLUS DOSE) AND PROPOFOL (SEDATIVE DOSE) ON ATTENUATION OF HEMODYNAMIC CHANGES DURING LAPAROSCOPIC SURGERIES
Introduction: Laparoscopic surgery is one of the most important diagnostic and therapeutic tools in the present surgical era. Laparoscopic surgeries require insufflation of the abdomen with some gas; usually, Carbon Dioxide is called pneumoperitonium, which induces pathophysiologic changes that complicate anesthetic management. To prevent and counteract these effects, appropriate monitoring and ph...
SOLUBILITY ENHANCEMENT AND DEVELOPMENT OF GUM BASED COLON TARGETED DRUG DELIVERY SYSTEMS OF QUERCETIN
The study aimed to enhance the solubility and develop a polymer (Guar Gum/Xanthan gum) based colon targeted drug delivery system of Quercetin promising in-vitro mouth-to-colon release profile. The solubility of the drug was enhanced by the solid dispersion method using solvent-evaporation technique; the optimized formulation 1:5 (Quercetin: PVP) was targeted to colon. Thermal studies proved that t...
EFFECTS OF POLY-UNSATURATED FATTY ACIDS ON LEUKOCYTE TELOMERE LENGTH AND INFLAMMATORY MARKERS IN D-GALACTOSE TREATED WISTAR ALBINO MALE RATS
The present study aimed at analyzing the effects of PUFA in D-galactose treated Wistar albino male rats by determining leukocyte telomere length using real-time quantitative PCR, Il-6, and high sensitive C-RP levels estimation using ELISA. D-galactose is administered for 42 days orally (100 mg/kg), and on 43rd-day, blood is collected from tail vein and plasma is separated and subjected for IL-6 an...
PRELIMINARY PHYTOCHEMISTRY, HPTLC AND FT-IR ANALYSIS IN GLYCOSMIS PENTAPHYLLA (RETZ.) DC. – AN ETHNOBOTANICALLY IMPORTANT MEDICINAL PLANT
Medicinal plants are often used by humankind since their evolution. They are known to have prominent therapeutic potential. The present work is conducted on Glycosmis pentaphylla (Rutaceae) an ethnobotanically important medicinal plant rich in secondary metabolites. The plant possesses metabolites like alkaloids, flavonoids, terpenoids, etc., which can be used against various illnesses. The plant ...
FABRICATION AND CHARACTERIZATION OF NANOSUSPENSION FORMULATION OF DIOSMIN FOR ENHANCED ORAL DELIVERY
Nanosuspension is a biphasic system consisting of drug particles dispersed in an aqueous surfactant or polymeric solution with a particle size between 10 to 1000 nm. Nanosuspension offers the unique advantage of increasing solubility of the pure drug resulting into faster drug absorption and hence achieving faster maximum plasma concentration. Hence, the aim of this research work was to formulate ...
ANTIMICROBIAL ACTIVITY OF HYDRO-ALCOHOLIC BARK EXTRACT OF PONGAMIA PINNATA
Kanuga (Pongamia pinnata), a plant belonging to Leguminosae described in Vedas has ethnobotanical importance and a variety of medicinal properties. Pongamia pinnata, commonly grown on the roads of India is used to heal wounds, treat many fungal infections, skin diseases and to clean teeth. The objective of the current study is to perform phytochemical analysis and appraise the antimicrobial activi...
FORMULATION AND DEVELOPMENT OF CURCUMIN AND MAG LOADED ENTERIC COATED TABLET IN THE TREATMENT OF IBD
The incidence of Inflammatory Bowel Disease (IBD) is now rising in developing countries and increasingly considered an emerging global disease. IBD is a chronic, intermittent disease. Symptoms of IBD varies from person to person and segment of the intestinal tract involved. IBD diagnosis depends on the various test, which requires blood testing, stool testing, endoscopy, biopsies as well as physic...
PHARMACOKINETIC EVALUATION OF GENTISIC ACID IN RATS: ORAL VERSUS INTRAVENOUS ADMINISTRATION
Gentisic acid (2, 5-dihydroxybenzoic acid) is a diphenolic compound, present abundantly in natural sources. It possesses several pharmacological activities such as nephroprotective, hepatoprotective, neuroprotective, etc. However, the available literature on oral absorption of gentisic acid is scarce. Thus, the aim of the present study was to determine the pharmacokinetic parameters and bioavailab...
HYPOACIDIC ACTIVITY OF THE HERBAL EXTRACT; A STUDY ON THE INHIBITION OF PARIETAL CELL K+/H+ ATPase PUMP
Gastrointestinal tract disorders occur due to an imbalance of gastric acid secretion and defensive factors. Histamine receptor blockers and proton pump inhibitors are the most prominent therapies in the treatment of GI tract disorders. Inhibition of the K+/H+ ATPase pump blocks the secretion of gastric acid (HCl) from the parietal cells. The adverse effects of currently available drugs have oblig...
BRAIN TARGETING OF WATER SOLUBLE DRUG THROUGH NASAL ROUTE USING FATTY ACID VESICLES
Fatty acid vesicles are novel vesicles incorporating fatty acids which enhance the brain targeting efficiency when compared to conventional liposomes. This study's objective was to prepare, characterize, and evaluate fatty acid vesicles for brain targeting of a water-soluble drug, atomoxetine HCl through nasal route. The atomoxetine HCl loaded fatty acid vesicles were prepared by using the reverse...
SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DETERMINATION OF GRANISETRON HYDROCHLORIDE IN BULK AND INJECTIONS
The present UV Spectrophotometric and RP-HPLC method was simple, accurate, precise, specific, and sensitive. Spectrophotometric method was developed in water and very useful for analysis of bulk drug and injection formulation. RP-HPLC method was developed in Phosphate buffer (pH 3.0 adjusted with orthophosporic acid) and acetonitrile (70:30) using column HiQsil C18 column (250 × 4.6 mm; 5 μm...
EFFECT OF VERMIWASH AND PLANT GROWTH REGULATORS ON GROWTH AND STEM ANATOMY OF HIBISCUS CANNABINUS L.
Growth and development events in plants are controlled by growth regulators and Phytohormones. These are found naturally in plants. Environmental Pollution is one of the major problems and reactions caused by artificial growth regulators and their low biodegradability has urged us to search for new biofertilizers with growth-regulating activity. Vermiwash is a liquid fertilizer that has been shown...
A COMPARATIVE STUDY OF THE BIOACCUMULATION OF PCB 126 IN THE INTESTINE TISSUE OF FRESHWATER FISH RASBORA DANICONIUS AND PUNTIUS TICTO (HAM.)
Two species of freshwater fish, Rasbora daniconius and Puntius ticto, were procured from a local freshwater body. They were subjected to chronic exposure by a daily sub-lethal dose of PCB 126, by use of a continuous flow-through method, for a period of 30 days. Estimation of bioaccumulation of PCB 126 in the intestine tissues of the fish was carried out at intervals of every 5 days using suitable ...
IN-VITRO EVALUATION OF PLEIOTROPIC PROPERTIES OF ROSUVASTATIN
Rosuvastatin, a selective and competitive inhibitor of enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, is marked as a first-choice drug amongst lipid-lowering agents because of its unique pharmacological and pharmacokinetic properties. An additional advantage of rosuvastatin administration is its specific, non-lipid pleiotropic properties, which are considered promising new fields of rese...
PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT ACTIVITIES OF VARIOUS EXTRACTS OF HELICHRYSUM PETIOLARE HILLIARD & B.L. BURTT USED FOR THE TREATMENT OF DIABETES MELLITUS IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA
Helichrysum petiolare is a herbal plant used in the Eastern Cape of South Africa to treat asthma, chest problems, colds, coughs, infections, diabetes, and high blood pressure. This study aimed to evaluate the phytochemical components and antioxidant activities of the acetone, ethanol, cold, and boiled aqueous extracts of H. petiolare. The phytochemical contents of the acetone, ethanol, and boiled ...
A STUDY OF METHOD DEVELOPMENT, VALIDATION AND FORCED DEGRADATION FOR SIMULTANEOUS QUANTIFICATION OF POVIDONE IODINE AND ORNIDAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC
An accurate, rapid economical, and simple, reliable assay method was developed and validated for the simultaneous estimation of Povidone-iodine and Ornidazole using RP-HPLC. In the proposed method, the efficient chromatographic separation was achieved using waters X-Bridge C8 column (150 × 2.1mm, 3.5µ) as a stationary phase and acetonitrile: 0.1% Orthophosphoric acid (50:50 v/v) as a mobile phas...
FORMULATION AND EVALUATION OF AL+3 -INDUCED GELLAN GUM-DILLENIA INDICA L. FRUIT GUM-BLENDED MICROBEADS FOR SUSTAINED DRUG RELEASE
The current communication deals with the development of Al3+ -ion induced ionotropically gelled microbeads made of deacetylated gellan gum (GG) and Dillenia indica L. fruit gum (DG) blends for sustained release of drugs. Aceclofenac (ACE) was utilized as a model drug candidate in the current study. These GG-DG microbeads of ACE were formulated by ionotropic gelation using AlCl3 as ionotropic cross...
DNA CLEAVAGE STUDIES OF SOME COMPLEXES OF SCHIFF BASE PYRIMIDINE ONE DERIVATIVES
A series of metal complexes, namely, Ni (II), Zn (II), Cu (II) and Pt (II), have been synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected to display DNA cleavage effect. Schiff base compoundof 2 - methyl - 3 - aminobenzopyrimidine - 4 - one (L1) was prepared by condensation of an equimolar mixture of 2-methyl-3...
INVESTIGATING THE IMPACT OF MANUFACTURING AND FORMULATION FACTORS ON THE COMPACTABILITY OF ACETAMINOPHEN TABLETS USING HECKEL AND MULTIVARIATE ANALYSIS
The present work evaluates the impact of alterable manufacturing and formulation factors on the physicomechanical properties of Acetaminophen (APAP); a poorly compressible Active Pharmaceutical Ingredient (API). By varying the amount of APAP and particle size of Microcrystalline Cellulose (MCC), six different formulations were prepared. These formulations were compressed into tablets at different ...
IMMUNO HISTOCHEMISTRY OF STEM CELL MARKER CD 133 AND SMOKING IN LUNG CANCER PATIENTS-A CORRELATIVE STUDY
Introduction: In India, lung carcinoma is the 5th most common tumor and 2nd most common tumor in males as per the ICMR [Indian Council of Medical Research] registry of 2002. In our Indian set up, smoking is still a leading cause of lung cancer and related morbidity and mortality. The role of many cancer stem cell markers like CD133, ALDH1, etc., is being investigated in the origin and prognosis of...
SYNTHESIS OF PERIWINKLE LEAF AND AMLA FRUIT SILVER NANOPARTICLES AND COMPARATIVE STUDY OF ANTIMICROBIAL ACTIVITY OF PLANT EXTRACT AND BIOSYNTHESIZED SILVER NANOPARTICLES
The study was performed with Methanolic Periwinkle leaf extract and aqueous Amla fruit extract. The activity was tested on Staphylococcus aureus and Escherichia coli by Agar Well Diffusion Method. Further, Silver Nanoparticles were synthesized from these Plant extract by Biological Method. Periwinkle leaf and Amla fruit extract showed antimicrobial activity against E. coli and S. aureus and also...
MOLECULAR MODELLING OF HIV-1 DRUG RESISTANT MUTANTS WITH REFERENCE TO WILD TYPE
Drug resistance mutations M184V and M184I are associated with lamivudine. Y181C and H221Y drug resistance mutations are associated with nevirapine and efavirenz and G190R and M230I drug resistance mutations are associated with efavirenz in the reverse transcriptase gene of HIV-1. In the present study, we attempted to identify the drug resistance mutations and interacting amino acids in the reverse...
PHARMACOGNOSTICAL STUDY OF THE AUTHENTICITY OF MORINGA OLEIFERA LEAVES
Moringa oleifera is widely used in Asia and Africa as an anti-inflammatory, anti-diabetic, and cold agent. However, there are no Moringa medicines on the Russian pharmaceutical market; therefore, it is of interest for research as a promising source of raw materials and introduction to the State Pharmacopoeia of Russian Federation. This study was conducted to compare the characteristics of the auth...
DESIGN, FORMULATION AND OPTIMIZATION OF RUTIN TRIHYDRATE EMULGEL BY RESPONSE SURFACE METHODOLOGY
Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated as...
COMPARISON OF IN-VITRO ANTIOXIDANT, ANTI-INFLAMMATORY ACTIVITIES AND GC-MS PROFILES OF NIGELLA SATIVA AND TRIGONELLA FOENUM-GRAECUM SEEDS
Inflammation, activated by oxidative stress, is the leading cause of all chronic diseases. Our culinary practices should include antioxidant and anti-inflammatory foods to combat these problems. Spices in India have been used traditionally not only as flavour enhancers in food but also as natural therapeutic agents in the prevention and treatment of a wide variety of ailments owing to the presence...
ANTIBACTERIAL ACTIVITY OF THREE URTICA SPECIES
The antimicrobial activity of Urtica dioica L. and Urtica urens L. has been reported; however, there are no reports regarding Urtica mexicana Liebm., which is widely distributed in central Mexico. U. urens and U. mexicana were collected in Amecameca and U. dioica was collected in Toluca Valley, both located in the state of Mexico. Crushed leaves of the plants were soaked consecutively in hexane, d...
IN-SILICO DOCKING OF BIOACTIVE COMPOUNDS DERIVED FROM CASSIA AURICULATA FLOWER EXTRACT AGAINST NS2B-NS3 PROTEASE OF DENGUE VIRUS
Dengue is a fatal disease connected to the environment that spreads rapidly. As there is currently no effective vaccine against dengue and no exact treatment for the disease, controlling and preventing dengue fever outbreaks are essential steps for keeping people healthy. Dengue viruses are a member of the Flaviviridae family, mosquito-borne, and causative agents for dengue fever. Bioactive compou...
EVALUATION OF NOOTROPIC ACTIVITY OF SEMECARPUS ANACARDIUM LEAVES IN RODENTS
Evaluation of nootropic activity of Semecarpus anacardium leaves ethyl alcohol extract on exteroceptive behavior and interoceptive behavior was investigated by use of Shuttle box, Continuous Avoidance Response Apparatus and Elevated plus-maze test, Scopolamine-induced amnesia, Diazepam-induced amnesia, and Sodium nitrite-induced amnesia. The beha-vioral study was done using Lithium- induced head t...
A VALIDATED FORCED DEGRADATION METHOD FOR CHARACTERIZATION OF ATAZANAVIR DEGRADANTS BY LC-MS/MS
The validated stability-indicating analytical method was developed for quantification of Atazanavir using Atazanavir-D9 as an internal standard by UPLC-ESI-MS/MS. The method was validated according to United States Pharmacopeia (USP) guideline with respect to the accuracy, precision, specificity, linearity, solution stability, robustness, sensitivity, and system suitability. Forced degradation stu...