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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 5 (2014) - Issue 10, October

Review Articles

 
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1.

PRESENCE OF ORGANIC IMPURITIES INTO ACTIVE PHARMACEUTICAL INGREDIENTS: A REVIEW

The presence of excess amount of pharmaceutical impurities in active pharmaceutical ingredients and control of these are a major issue for all pharmaceutical companies. It is very essential to know the presence of impurities in the drug substances and control them up to certain level to avoid adverse effects. Impurities in organic drug molecules can be developed during organic synthesis, formulati...

Rajat Ghosh*, Katon Darin and Panchali Deb

Department of Pharmacy, Tripura University (A Central University), Suryamaninagar -799 022, West Tripura, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4078-08

4078-4108

1744

3977

2.

A REVIEW ON ANTIASTHMATIC ACTIVITY OF TRADITIONAL MEDICINAL PLANTS

Plants have played an important role as various medicinal agents since ages. Medicinal herbs have been used in one form or another, under indigenous systems of medicine like Ayurveda, Siddha and Unani.  The knowledge of Indian medicinal plants and their uses in the Ayurvedic and Unani system of medicine have led to many scientific investigations and researches throughout the world. Asthma is a co...

Santosh Kumar Singh*, Jay Ram Patel , Prashant Kumar Dubey and Sonia Thakur

Mittal Institute of Pharmacy, Opp. Bhopal Memorial Hospital and Research Centre, By Pass, Nabibagh, Bhopal- 462038, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4109-16

4109-4116

4323

1668

3.

A REVIEW: ROLE OF DOXORUBICIN IN TREATMENT OF CANCER

Cancer is a very complex genetic disorder that is mainly caused by carcinogens. Carcinogens can be present in air, water, food, chemicals and sunlight that are exposed to the people. In case of leukemia the body produces large numbers of abnormal white blood cells. In the study  of blood cancer that is leukemia, blood  disorders  through  visual  inspection  of  microscopic  images  of  ...

Ajay Kumar*, Babita Gautam, Chetan Dubey, Puspendra Kumar Tripathi

Department of Pharmacy, Rameshwarm Institute of Technology and Management, Lucknow- 227202, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4117-28

4117-4128

4548

1157

4.

SAFETY AND ANTITUMOR ACTIVITY OF GEFITINIB: AN OVERVIEW

Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor, a promising anticancer agent for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) especially in EGFR mutated patients. It acts by interfering with the proliferation and survival of cancer cells and other host dependent process promoting cancer cell growth by blocking signal transduction pa...

Minakshi Gupta, Komal Goswami , Rakesh Kumar Marwaha and Harish Dureja *

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, HR -124001, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4129-40

4129-4140

1707

643

Research Articles

 
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5.

MOLECULAR MODELLING, 3D-QSAR, AND DRUG DOCKING STUDIES ON THE ROLE OF NATURAL ANTICOAGULANT COMPOUNDS IN ANTITHROMBOTIC THERAPY

Thromboembolic disorders are the leading cause of human mortality. Therefore, development of effective anticoagulant therapy is critical. Factor XIIIA (FXIIIA) protein is a crucial factor in the blood coagulation cascade, and hence it is a vital target for evolution of new antithrombotic agents. Structure-function studies of clotting factor active sites, clot formation, and thrombus structure have...

Prathusha Kakarla, Amith R. Devireddy, Madhuri A. Inupakutika, Upender R. Cheeti, Jared T. Floyd, Mukherjee M. Mun, Raelyn N. Vigil, Russell P. Hunter, Manuel F. Varela*

Department of Biology, Eastern New Mexico University, Station 33, Portales - 88130, New Mexico, USA

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4141-52

4141-4152

1809

717

6.

EFFECT OF HIPPOPHAE RHAMNOIDES ON COGNITIVE ENHANCEMENT VIA NEUROCHEMICAL MODULATION IN SCOPOLAMINE INDUCED SPRAGUE DAWELY RATS

Hippophae rhamnoides, is known well for its cardio protective, immunomodulatory and antioxidant property, hence an effort was taken to evaluate its neuroprotective effect on scopolamine induced neurochemical impairment and cognitive dysfunction. Male Sprague Dawley rats were induced with 2mg/kg body weight of scopolamine as a single dose for 14 days, along with test formulation for four weeks and ...

Shivapriya Shivakumar , K. Ilango , Aruna Agrawal and G.P. Dubey *

Faculty of Ayurveda, Siddhant Dharsan, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4153-58

4153-4158

1639

447

7.

AVERTING CANCER EFFECT OF PARACETAMOL AND PHENACETIN BY N-ACETYLCYSTEINE AND ITS ANALOGUES

Comparative DFT calculations have been studied for Paracetamol (PA) and its analogue Phenacetin (PH) to verify their electronic resemblance. DFT studies, concluded that PA and PH have the lower energy predominant trans conformers with respect the cis-conformers. From TD-DFT studies, the electronic transition energies between the ground state and singlet excited states for the two conformers have b...

Anwar El-Shahawy. Nagwa Abo El-Maali and Hassan H. El-Hawary

Chemistry Department-Faculty of Science, Assiut University 71516-Egypt.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4159-69

4159-4169

1512

494

8.

ANTIDIABETIC ACTIVITY AND POTENTIAL MECHANISM OF MUKIA MADERASPATANA LINN. IN RATS INDUCED BY HIGH FAT DIET AND LOW DOSE STZ

To evaluate the anti-diabetic effects of the Mukia maderaspatana Linn (MML), and to explore the possible mechanism. High fat diet and STZ (35 mg/kg) induced diabetic rats were administered with MML at two dose levels (200 and 400 mg/kg/day, p.o.) for 21 days. Fasting blood glucose, lipid and lipoprotein levels such as triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol ...

R. Vadivelan* and S.P. Dhanabal

Department of Pharmacology, JSS College of Pharmacy, (JSS University, Mysore, Karnataka), Udhagamandalam, Tamilnadu, India -643001

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4170-75

4170-4175

1342

423

9.

STUDY OF DIFFERENT PROCESSING PARAMETERS FOR POLYLACTIC ACID MICROSPHERES FORMULATIONS

In order to evaluate the effects of different processing parameters on drug-loaded microspheres, the solvent evaporation technique was chosen as the formulation method. Indomethacin-loaded Polylactic acid microspheres were prepared by varying drug masses, then by changing the stirring speed. They were analyzed for their drug content, physical morphology, size, polymer-drug physicochemical compatib...

Dima Moussa, Rima Kassab* and Paolo Yammine

Department of Chemistry, Faculty of Sciences, University of Balamand, P.O. Box: 100 Tripoli, Lebanon

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4176-81

4176-4181

1433

405

10.

PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITIES OF CRUDE EXTRACT OF LEPIDIUM SATIVIUM SEEDS GROWN IN ETHIOPIA

Lepidium sativum Linn. locally known as 'fetto' is a fast growing edible herb which belongs to the family Brassicaceae is traditionally used for the treatment of various human ailments including cold, headache, colic, abdominal pain, dysentery, swellings and aphrodisiac in Ethiopia. Phytochemical screening and antimicrobial activities were conducted on seeds of Lepidium sativium grown in Ethiopia....

Solomon Girmay Berehe* and Aman Dekebo Boru

Department of Chemistry, Adama Science and Technology University, P.O. Box: 1888, Adama, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4182-87

4182-4187

2120

1234

11.

SPECTROPHOTOMETRIC QUANTITATIVE DETERMINATION OF AMBROXOL HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS USING PDAB REAGENT

A simple, sensitive, cost effective spectrophotometric method has been developed and validated for the determination of Ambroxol hydrochloride (AMB), in bulk drug and its pharmaceutical formulations. The method is based on the formation of a Schiff base with PDAB; the reaction of drug with reagent gives a bright yellow colour. The so formed coloured species absorbance was measured at its absorptio...

K. Siddappa* and Prashant C. Hanamshetty

Department of Studies and Research in Chemistry, Gulbarga University, Gulbarga -585106, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4188-94

4188-4194

2479

674

12.

DEVELOPMENT OF ECONOMIC TRANSDERMAL PATCHES CONTAINING LORNOXICAM FOR TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY MODELS IN ALBINO RATS (A PRECLINICAL STUDY)

Objective: To formulate economic transdermal patch of lornoxicam (LX) and to study its anti-inflammatory activity on acute and chronic inflammatory in rat models Method: Three LX transdermal patches (F1, F2 and F3) consist of Eudragit RL-100 and RS-100 in three different ratios (1:2, 1:1 and 2:1)were prepared respectively by the solvent evaporation technique. All formulations contain diethylpht...

Nagla Ahmed El Nabarawy*, Rehab A. Abd Elmonem and Hadel A. Abo Enin

National Egyptian Center of Environmental and Toxicological Research (NECTER), Cairo University, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4195-02

4195-4202

1438

468

13.

SPONTANEOUS REPORTING OF ADVERSE DRUG REACTIONS IN UAE: OBSTACLES AND MOTIVATION AMONG COMMUNITY PHARMACISTS

Spontaneous reporting of adverse drug reactions (ADRs) is a broadly experienced technique of practicing pharmacovigilance (PV) activity.  However, the progression of pharmacovigilance programs is limited by under-reporting of ADRs, as it is considered one of the major problems associated with PV programs development.  This is the first study of its kind in the United Arab Emirates (UAE) that exa...

Sundos Qassim*, ZakiaMetwaly , Mohammad Shamsain and Yassin AlHariri

Clinical Pharmacy and Pharmacy Practice Department, Pharmacy College, Ajman University of Science and Technology, Ajman, UAE.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4203-08

4203-4208

1725

619

14.

HEPATOPROTECTIVE ACTIVITY OF A STANDARDIZED POLY- HERBAL LIVER FORMULATION

The present study compiled the formulation and standardization of polyherbal liver syrup named “LivPro” followed by in-vivo and in-vitro hepatoprotective activity in CCl4 intoxicated rat. LivPro was formulated by using lyophilized ethanolic extract of A. millefolium, C. spinosa, C. intybus and P. kurroa. Further, the standardization of LivPro was performed following the guidelines of WHO and I...

P. Bigoniya* and C.S. Singh

Radharaman College of Pharmacy, Ratibad, Bhopal- 462 002, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4209-18

4209-4218

1538

573

15.

SERUM LEVELS OF SELENIUM IN UNCOMPLICATED TYPE-2 DIABETIC PATIENTS AND HEALTHY INDIVIDUALS

Selenium (Se) plays a vital role in maintaining body’s homeostasis. Selenoproteins have been found to play an integral role in body’s defense against oxidative stress. Type-2 diabetes mellitus is considered as inflammatory state with high oxidative load and is one of the major chronic diseases prevalent in Pakistan. Serum levels of selenium in type 2 diabetic patients and healthy individuals w...

Munaza Riaz*, Khawaja Tahir Mahmood and Khadija Irfan

Department of Pharmacy, Lahore College for Women University, near Wapda Flats Jail Road Lahore – 54000, Punjab, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4219-24

4219-4224

1232

391

16.

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF AMBROXOL HYDROCHLORIDE USING NATURAL POLYMER

Ambroxol hydrochloride is a potent mucolytic agent capable ofinducing bronchial secretions used in the treatment of respiratory disorders. The Sustained release matrix tablets containing 75 mg Ambroxol hydrochloride were developed using different drug: polymer ratios. Sustained release matrix tablets were prepared by wet granulation method. Granules wereprepared and evaluated for loose bulk densit...

Sunil Kumar*, B. Someswara Rao and Suresh V. Kulkarni

Department of Pharmacy, Sree Siddaganga College of Pharmacy, Tumkur - 572102, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4225-32

4225-4232

2275

708

17.

STRUCTURAL DYNAMICS OF LACTOBACILLUS RHAMNOSUS PROTEINS UNDER COPPER SULPHATE AND ZINC CHLORIDE STRESS

Lactobacillus rhamnosus plays an important role as probiotic often associated with beneficial health effects. Although copper and zinc are trace metals, they are toxic at high concentrations. In this paper, bioinformatic tools and molecular modelling approach was adopted to explore the structure of L. rhamnosus under copper sulphate and zinc chloride stress. The differentially expressed proteins ...

S. Sreevani, K. Chandrasekhar and J. Pramoda Kumari*

Department of Microbiology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4233-39

4233-4239

1317

438

18.

DOSE-DEPENDENT EFFECT OF WITHANIA SOMNIFERA ON THE CHOLINERGIC SYSTEM IN SCOPOLAMINE-INDUCED ALZHEIMER’S DISEASE IN RATS

The present study was aimed to determine whether the methanol and aqueous extracts from the medicinal plant, Withania somnifera (root), could inhibit acetylcholinesterase (AChE) in scopolamine-induced Alzheimer’s rats. The rats were randomly divided into different groups of 5 each: normal control rats treated with saline; Scopolamine (2mg/Kg b.w. i.p.) – induced Alzheimer’s rats treated with...

G. Visweswari*, Rita Christopher and W. Rajendra

Post-Doctoral Fellow, C/o Dr. Rita Christopher, Professor and Head of the Department, Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore-560 029, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4240-48

4240-4248

1450

536

19.

ANTIFUNGAL GLYCEROGELATIN: ATTEMPT AT FORMULATION AND EVALUATION OF A POTENTIAL TRANSUNGUAL DRUG DELIVERY SYSTEM

Onychomycosis representing about 30% of mycotic cutaneous infections is the fungal infection that affects the nails. Although not life threatening, it adversely affects the psychology of the patient whose nails become yellow, discolored, brittle and unsightly. It may also pose serious problems in immunocompromised individuals. The current market of products for treatment of onychomycosis includes ...

Rohit Joshi, Priyanka Harbola* and Savita Pandey

Devsthali Vidyapeeth, College of Pharmacy, Lalpur, Kiccha Road Rudrapur, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4249-53

4249-4253

1668

783

20.

IN VITRO STUDIES OF IMMUNOMODULATORY AND FREE RADICAL SCAVENGING ACTIVITIES OF FLAVONOID ISOLATED FROM MIMOSA PUDICA

Flavonoid isolated from Mimosa pudica was evaluated for its radical scavenging and immunomodulatory activities in vitro.  Aim of this study is to isolate flavonoid from Mimosa pudica and to determine its antioxidant and immunomodulatory properties. Flavonoid was isolated from dried samples of Mimosa pudica using soxhlet extraction in 80% methanol and purified by column chromatography. Various tes...

Joby Jose , Sudheesh Sudhakaran*, Dhanya A.T., Sumesh Kumar T.M. , Sony Jayaraman and Jayadevi Variyar E.

Assistant Professor and Head of the Department of Chemistry, School of Chemical Sciences, Swami Anandatheertha Campus, Payyanur, Kannur University, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4254-61

4254-4261

2801

1730

21.

PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTIONS OF ATORVASTATIN WITH GUGGULSTERONE IN HYPERLIPIDEMIC RATS

Atorvastatin is a HMG-CoA reductase inhibitor used in the treatment of hyperlipidemia. Guggulsterone is a herbal product used in hyperlipidemia. The present work was aimed to study the pharmacokinetic and pharmacodynamic interactions of atorvastatin with guggulsterone in hyperlipidemic rats. Wistar albino rats with induced hyperlipidemia were divided into six groups (n=6). Blood samples were colle...

Kalam Sirisha*, Puchchakayala Goverdhan , Akunuri Swarnalatha and Akina Sravanthi

Associate Professor & Head, Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ram Nagar, Hanamkonda, Warangal - 506001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4262-68

4262-4268

1506

457

22.

ANTIHYPERLIPIDEMIC ACTIVITY OF ALCOHOLIC EXTRACTS OF TRICHOSANTHES ANGUINA IN TRITON WR 1339 INDUCED HYPERLIPIDEMIC RATS

Hyperlipidemia is one of the major risk factors for coronary heart diseases. In this study, antihyperlipidemic activity of methanolic extract of fruits of Trichosanthes anguina Linn. (META) against Triton WR 1339 induced hyperlipidemia in rats was evaluated. META was administered at doses of 125, 250, and 500 mg/kg body weight (b.w.) to Triton induced hyperlipidemic rats. Atorvastatin was used as ...

Ritu Mishra , Kanika Pandit , Ashok M. Bhagwat and Brijesh S.*

Assistant professor, School of Science, SVKM’s NMIMS University, Bhaidas Building, 2nd Floor, Bhakti Vedanta Swami Marg, Vile Parle (West), Mumbai – 400 056, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4269-74

4269-4274

1667

477

23.

HEPATOPROTECTIVE POTENTIAL OF AQUEOUS AND ETHANOLIC STEM-BARK EXTRACTS OF PONGAMIA PINNATA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

Introduction: Pongamia pinnata is commonly known as karanja. In Ayurvedic and Unani system of medicine, it has been used as anti-inflammatory, anti-plasmodial, anti-nociceptive, anti-hyperglycaemic, anti-lipidoxidative, anti-diarrheal, anti-ulcer, anti-hyperammonemic, antioxidant etc. Moreover, it has been used traditionally in the treatment of liver disorders. However, there are no scientific bas...

Harleen Kaur , Mohanjit Kaur , Amarjeet Singh and Bimlesh Kumar*

Department of Pharmaceutical Sciences, Lovely Professional University, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4275-80

4275-4280

1343

415

24.

SIMULTANEOUS QUANTIFICATION OF THREE NAPHTHOQUINONES FROM IMPATIENS BALSAMINA L. LEAVES USING VALIDATED RP-HPLC METHOD

Impatiens balsamina belonging to family Balsaminaceae is commonly known as terda. The plant has extensive range of phytoconstituents like naphthoquinones, coumarins, glycosides, phenolic acids, flavonoids, anthocyanidins and steroids which have effective antimicrobial, anti-anaphylaxis, anti-allergic, anti-pruritic and anti-inflammatory activity. Potent naphthoquinones like lawsone, methylene-3, 3...

A.A. Sonandkar*, P.N. Agrawal, D.M. Madrewar, S.M. Labana and A.P. Jain

Prin. K.M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai- 400005, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4281-87

4281-4287

1417

434

25.

EVALUATION OF THE ANTICONVULSANT ACTIVITY OF ETHANOL EXTRACT OF PSIDIUM GUAJAVA (GUAVA LEAVES) IN ALBINO MICE

ABSTRACT: Objective: To evaluate the anticonvulsant activity of ethanolic extract (200mg/kg & 400mg/kg) of Psidium guajava (guava leaves) in albino mice. Methods: Albino mice (25-30gms) of either sex were randomly selected and divided into 4 groups of 6 mice each, Group I (control) – Distilled water (vehicle) 1ml, Group II (Standard) – Valproic acid (40mg/kg), Group III - T1, Ethanol...

V.H. Pushpa, K. Padmaja Shetty*, N. Sushma, H.L. Kalabaharathi and A.M. Satish

Department of Pharmacology, JSS medical College, JSS University, Mysore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4288-92

4288-4292

2293

765

26.

ASSESSMENT OF KNOWLEDGE AND PRACTICE TOWARDS BIRTH PREPAREDNESS AND COMPLICATION READINESS AMONG WOMEN IN MEKELLE, NORTHERN ETHIOPIA: DESCRPTIVE CROSSECTIONAL

Background: Birth preparedness and complication readiness (BP/CR) are interventions designed to address the delays by encouraging pregnant women, their families, and communities to effectively plan for births and prepare for emergencies. Objective: To assess the knowledge and practice towards birth preparedness and complication readiness among women in Mekelle town, 2013. Methods and Materia...

Balem Dimtsu* and Gessessew Bugssa

Lecturer, Department of Midwifery, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4292-01

4293-4301

4616

944

27.

PROTECTIVE EFFECTS OF COCCINIA GRANDIS LEAF EXTRACT: BEHAVIOURAL, ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND HISTOLOGICAL FEATURES OF DIABETIC NEUROPATHY

The aim of present study was to evaluate the nociceptive, neuro-muscular coordination, electrophysiological, biochemical and histological features of diabetic neuropathy in streptozotocin induced diabetic rats and the protective effects of Coccinia grandis leaf methanolic extract. Coccinia grandis (200mg/kg per day) was given to diabetic rats for 3 weeks. Metformin (150mg/kg body weight) was used ...

Bhaskar Nagilla and Pratap Reddy K*

Neurobiology lab, Department of Zoology, University College of Science, Osmania University, Hyderabad – 500 007, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4302-09

4302-4309

1754

422

28.

DETERMINATION OF HEAVY METALS IN FIVE MAJOR INGREDIENTS OF HERBAL MEDICINES

Ayurvedic Medicine originated in India more than 2000 years ago and relies heavily on herbal medicine products. Approximately 80% of India’s 1 billion populations use Ayurveda through more than one-half million Ayurvedic practitioners working in 2860 Ayurvedic hospitals and 22100 clinics. Ayurveda’s popularity in Western countries has increased. There are several reports of adverse effects of ...

Indrajit Sen* and Babla Vinayak Pendam

Agilent Technologies, Inc. Plot no CP-11, Sector-08.IMT Manesar, Gurgaon-122051, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4310-14

4310-4314

2947

618

29.

A SURVEY ON LINE OF MANAGEMENT OF HYPERTENSION BY PRIMARY HEALTH CARE PHYSICIANS IN PUDUDCHERRY

Hypertension is one of the most important public health problems globally. If the blood pressure is effectively controlled, many of the disastrous complications of hypertension such as myocardial infarction, stroke, kidney failure, heart failure and death can be prevented or delayed. Patients usually attend the family physicians first for any illness they are suffering including hypertension. Henc...

M. Thulasimani*, S. Amarnath , Arun Sharma , S. Basalingappa , S. Jaikumar and S. Ramaswamy

Department of Cardiology, Indira Gandhi Government General Hospital & Post graduate Institute, Puducherry-605001, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4315-19

4315-4319

1265

423

30.

ANTI-ASPERGILLUS ACTIVITY OF LANTANA CAMARA LINN.

Herbal fungicides are gaining great interest because of their cost effective and ecofriendly attributes. If this antifungal potency resides in weeds, it will be a great advantage because of their large population and to effectively develop novel drug from weeds being considered as a waste material.  The present study aims to assess the anti-aspergillus activity of a common weed Lantana camara.  ...

H. Barkath Nisha, S. Iswarya, V. Kavitha, Asit Baran Mandal and A. Gnanamani*

Microbiology Division, CSIR-CLRI, Adyar, Chennai 20, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4320-24

4320-4324

3447

545

31.

METAPHORICAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (2D & 3D-QSAR) ANALYSIS OF TYLOPHORINE DERIVATIVES AS EFFICACIOUS IN ANTIMALARIAL DRUG DESIGN

Quantitative Structure Activity Relationship (QSAR) for tylophorine derivatives acting as Plasmodium kinases inhibitors has been developed. The proposed 2D-QSAR model was found to be statistically significant with respect to training, cross-validation, and external validation.The contribution of carbon chains with aromatic and electronegative features are found to be the most important descriptors...

S.K. Patel , L. George , V.M. Khedkar , M.Y. Lone , P.C. Jha*, Y.T. Jasrai , H.A. Pandya and H.N. Highland

Assistant Professor, School of Chemical Sciences, Central University of Gujarat, Sector-30, Gandhinagar - 382030, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4325-38

4325-4338

1443

510

32.

SYNTHESIS AND CHARACTERISATION OF BIO-INORGANIC TRANSITION METAL COMPLEXES DERIVED FROM NOVEL BIGINELLI ADDUCT COUPLED SCHIFF’S BASES

Novel Schiff base comprising 4-aminoantipyrine with Biginelli adducts of salicylaldehyde has been designed and synthesised. Solid metal complexes of this Schiff base with Ni(II),Zn(II),Cd(II) and Hg(II) metal ions were synthesised and characterised by elemental analysis, magnetic susceptibility, molar  conductance, ESI mass, IR,NMR and UV-Vis spectral studies. From the data it has been observed t...

Rohini Chandran and S. Arul Antony *

PG and Research Department of Chemistry, Presidency College, Chennai-600 005, Tamil Nadu, South India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4339-50

4339-4350

1696

1080

33.

FRUITS OF SCINDAPSUS OFFICINALIS ATTENUATES PYLORUS LIGATION INDUCED ULCER IN RATS

Objective: Scindapsus officinalis hasbeen reported to have antioxidant, analgesic, anti-inflammatory, antibacterial and antihistaminic activity. Peptic ulcer disease involves inflammation and oxidative stress. So, the present study was carried out to evaluate the potential of hydroalcoholic extract of Scindapsus officinalis fruits as an antiulcer agent. Materials and Methods: In this study phar...

Adarsh Choudhary*, Amarjeet Singh ,Navneet Duggal and Bimlesh Kumar

Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4351-58

4351-4358

1421

464

34.

EVALUATION OF IMMUNOMODULATORY ACTIVITY OF THE FLAVANOID OF KIGELIA AFRICANA

Objective: Modulation of the immune responses to alleviate the diseases has been of interest for many years. Thus, a real need exists to protect our immune systems and lead healthier lives. Hence the present study is aimed to evaluate the immunomodulatory activity of the Flavonoid of Kigelia africana (Family: Bignoniaceae). Methods: The assessment of immunomodulatory activity on cell mediated a...

P.K.M. Nagarathna, K. Reena*, Sriram Reddy and Johnson Wesley

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4359-65

4359-4365

1972

627

35.

SCREENING OF PHENOLIC CONTENT, ANTIOXIDANT AND IN VITRO EYE IRRITATION ACTIVITIES FROM APIACEAE FAMILY (DRY SEEDS) FOR POTENTIAL COSMETIC APPLICATIONS

Cosmetic applications of spices and herbs are well recognized. Apart from preservative and antimicrobial activities, spices display copious antioxidant activity. Inclusion of these antioxidants in topical supplements has proved to be effective against oxidative ageing. However, food and contact allergy to most spices makes it mandatory to screen for skin and eye irritation activities prior to cosm...

Manjari R. Shah*, Kshitij V. Satardekar and Siddhivinayak S. Barve

Kelkar Education Trust’s Scientific Research Centre, Mulund (East), Mumbai-400 081, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4366-74

4366-4374

1645

615

36.

FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING TABLETS OF LORATADINE

Loratadine a long-acting tri-cyclic antihistamine with selective peripheral histamine H1-receptor antagonistic activity, is used for the symptomatic relief of allergic conditions like runny nose, itchy or watery eyes, sneezing and nasal or throat itching and chronic urticaria. It is stable in acidic pH, has a narrow therapeutic absorption window in the GI tract and found to be absorbed at proximal...

M. Yasmin Begum*, J. Avanthi, A. Shwetha, T. Madhuri, M. Sudhakar and D. Naveen

Department of Pharmaceutics, Malla Reddy College of Pharmacy, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4375-85

4375-4385

2922

839

37.

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NEWLY 1, 2, 4-TRIAZOLE DERIVATIVES

A series of 1-(2-(4H-1,2,4-triazol-4-yl)ethylamino)-3-chloro-4-(5-methoxy/ehthoxy-2-substituted alkyl/aryl-1H-indol-3-yl)azetidinones (4a-4h) and 1-(2-(4H-1,2,4-triazol-4-yl) ethylamino)-3-chloro-4-(5-methoxy/ethoxy-2-substituted alkyl/aryl-1H-indol-3-yl)thiazolidinones (5a-5h) have been synthesized by the reaction of 3-((2-(2-(4H-1,2,4-triazol-4-yl)ethyl)hydrazono)methyl)-5-methoxy/ethoxy-2-subst...

I. Singh* and A. Kumar

Assistant Professor, Department of Chemistry, Janta Vadic College, Baraut (Baghpat), Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4386-94

4386-4394

1483

495

38.

IN-VITRO ANTI-INFLAMMATORY SCREENING OF A POLY HERBAL SIDDHA MEDICINE, “ASHWATHI CHOORANAM”

Siddha is one among the ancient systems of Indian medicine. Its reliability lies in the fact that it is time-tested, devoid of any drastic adverse effects and deep-rooted in the culture and heritage of India.  The role of this system in treating chronic diseases is being widely felt now-a-days.  The challenges in treating such conditions with the currently available drugs (Non-Steroidal Anti-inf...

A. Shifana Raheema, C. Aswini, M. Sathya, S. Merish and Thomas M. Walter*

Department of Pharmacology, Government Siddha Medical College, Palayamkottai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4395-99

4395-4399

2000

940

39.

PHYTOCHEMICAL, ANTIOXIDANT AND CYTOTOXICITY STUDY OF THE METHANOLIC EXTRACTS OF LEAVES OF TRAPA BISPINOSA ROXB.

About 80% of the population living in rural areas in developing countries depends on traditional medicine for their health care needs. Many of the powerful drugs used in modern medicines originated in plants. Today’s plant-based drugs treat a range of diseases, from headaches to cancer. The objective of the present study was to evaluate phytochemical, antioxidant potential and cytotoxicity of me...

Tania Binte Wahed*, Md.Fokhrul Islam , Ratna Sarkar and Sonia Binte Wahed

Assistant Professor, Department of Pharmacy, Jahangirnagar University, Savar,Dhaka-1342, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4400-05

4400-4405

1677

655

40.

IMPACT OF GEOGRAPHIC VARIATION ON PHYSICOCHEMICAL PROPERTIES OF NEEM (AZADIRACHTA INDICA) SEED OIL

The applications of the seed oil are defined by its quality through many factors, including seed origin. The study aims to investigate the physicochemical characteristics to compare the oil quality of plant Azadirachta indica (Family: Meliaceae), grown in different geographical areas, Malaysia and Sudan. Oils were extracted through Soxhlet method via hexane for the duration of 6 h. The characteris...

S. Jessinta , H.N. Azhari*, N.T. Saiful and H.N. Abdurahman

Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang Darul Makmur, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4406-13

4406-4413

2329

721

41.

CONSERVED WATER MIMIC INHIBITOR DESIGN FOR hIMPDH (INOSINE MONOPHOSPHATE DEHYDROGENASE): MD SIMULATION AND DOCKING STUDIES OF IMP-ANALOGS

Inosine Monophosphate Dehydrogenase (IMPDH) plays very important role in Guanosine Monophosphate (GMP) biosynthesis. Type I hIMPDH is expressed at lower levels in all cells, whereas type II is especially observed in acute myelogenous leukaemia, chronic myelogenous leukaemia cancer cells, so it is thought to be an active target for leukemic drug design. MD-simulation studies of the solvated  model...

Deepak K. Mishra , Bishnu P. Mukhopadhyay*, Avik Banerjee and Subrata Dasgupta

Professor, Department of Chemistry, National Institute of Technology-Durgapur, Mahatma Gandhi Avenue, Durgapur, Dist. Burdwan - 713209, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4414-23

4414-4423

1260

356

42.

ASSESSMENT OF FOOD, ETHNOBOTANICAL AND ANTIBACTERIAL ACTIVITY OF TRICHOSANTHES CUCUMIRINA L.

Trichosanthes cucumirina L., locally known as “Chachindra” among the tribal and rural mass of Similipal Biosphere Reserve (SBR) forest. Plant parts are used as ethnomedicine among inhabitants of SBR. They use the fruits, leaves and roots against various diseases and traditional practices are continuing since long. Leaves are used against microbial infections, roots against diabetic and fruits ...

Prakash Kumar Tripathy, Sanjeet Kumar and Padan Kumar Jena*

Department of Botany, Ravenshaw University, Cuttack-753 003, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4424-31

4424-4431

1137

337

43.

IN VITRO ANTICANCER ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF BACOPA MONNIERI (L.) WETTST.

Plants have played a significant role in the treatment of cancer and infectious diseases for the last many decades. Natural products have been rediscovered as important tools for drug development despite advances in combinatorial chemistry. Bacopa monnieri (L.) Wettst. (Scrophulariaceae) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. The various ...

A. Patil*, K. Vadera , D. Patil , A. Phatak , A. Juvekar and N. Chandra

Vice Principal, Associate Professor, Dept. of Botany-Herbal Sciences, Birla College, Kalyan - 421 304, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4432-38

4432-4438

4413

1502

44.

WOUND HEALING ACTIVITY OF URSOLIC ACID STEAROYL GLUCOSIDE (UASG) ISOLATED FROM LANTANA CAMARA L.

Lantana camara L. is regarded as a notorious weed and has found several practices in folk medicine in many parts of the world. Leaves of Lantana camara L.is traditionally used for cuts, swellings and burns for their healing property. The leaves are found to contain various chemical constituents such as monoterpenes, sesquiterpenes, triterpenes, and glycosides. In present study, Ursolic acid stearo...

Mohammad Pravez , and Alok Kumar Patel*l

Molecular Microbiology Laboratory, Department of Biotechnology, IIT Roorkee - 247667, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4439-44

4439-4444

1599

617

45.

PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITIES OF SOME WILD MEDICINAL PLANTS OF THE WESTERN MEDITERRANEAN COASTAL REGION, EGYPT

Four wild plant species (Chrysthanthemum cornarium, Capparis spinosa, Carthamus lanatus, Haplophyllum tuberculatum)  were investigated for their antioxidant activity, phenolic and flavonoid contents of  their methanolic extracts. The antioxidant activity of the extracts was assessed their free radical scavenging properties using DPPH. Total phenolics and total flavonoids were detected by spectro...

H.M. Abou-Zeid*, L.M. Bidak, and Y.M. Gohar

Botany & Microbiology department, Faculty of Science, Alexandria University, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4445-55

4445-4455

1465

467

46.

IN VITRO ASSESSMENT OF ANTIOXIDANT AND ANTIPROLIFERATIVE EFFICACY OF ANDROGRAPHIS PANICULATA

The present study investigated the antioxidant and antiproliferative efficacy of Andrographis paniculata, a well-known medicinal plant, using in vitro systems. The dried leaves of A. paniculata were powdered and subjected to successive solvent extraction taking from polar to non-polar solvents (descending polarity) and simultaneously from non-polar to polar solvents (ascending polarity). Solvents ...

G. Deora

Department of Human Genetics, Guru Nanak Dev University, Amritsar -143005, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4456-66

4456-4466

1485

550

47.

DEVELOPMENT AND EVALUATION OF COMPRESSION COATED TIMED-RELEASE TABLETS OF CANDESARTAN CILEXETIL FOR CHRONOTHERAPY OF HYPERTENSION

Chronotherapy involves the release of drug to the systemic circulation based on the circadian rhythm associated with the pathopysiology of a disease.Candesartan Cilexetil, an anti-hypertensive drug is formulated to contribute to chronotherapy of hypertension. Solubility study of drug (BCS Class II) in various media indicated maximum solubility in pH 6.8 sodium phosphate buffer containing 1% SLS. S...

B.L.R. Madhavi* and K. Deepika

Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad-500027, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4467-77

4467-4477

1561

591

48.

ENHANCEMENT OF AQUEOUS SOLUBILITY AND DISSOLUTION OF TELMISARTAN USING SOLID DISPERSION TECHNIQUE

The present study was aimed to improve the water solubility and bioavailability of telmisartan by solid dispersion technique. Telmisartan is 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid. Telmisartan is practically insoluble in water. Telmisartan is an angiotensin II receptor antagonist (ARB), used in the management of hypertension. Solid dis...

A. Dubey*, A. A. Kharia and D. P. Chatterjee

Oriental College of Pharmacy, Department of Pharmaceutics, Thakral Nagar, Raisen Road, Bhopal, Madhya Pradesh, 462021, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4478-85

4478-4485

2757

936

49.

EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM AND SYNTHESIS OF ITS DERIVATIVES: COMPARATIVE EVALUATION OF ANTI-OXIDANT ACTIVITIES

The objective of this study was to extract ursolic acid (UA) from Ocimum sanctum,to synthesize its derivatives and to examine the improvement of antioxidative activity. Present work involved structural modification of UA at the C-3 and C-28 positions. UA derivatives namely UA-4 and UA-7 with distinct property were synthesized. Comparative evaluation of anti-oxidant activity of UA, UA-4 and UA-7 us...

Apsara Batra* and V. Girija Sastry

Assistant Professor Pharmaceutical Chemistry Division, NCRD’S Sterling Institute of Pharmacy, Nerul-400706, Navi-Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4486-92

4486-92

1384

588

50.

IN VITRO ANTIMICROBIAL ACTIVITY OF EDIBLE OILS AGAINST HUMAN PATHOGENS CAUSING SKIN INFECTIONS

In recent years, a large number of oils and their constituents have been investigated for their antimicrobial properties against bacteria and fungi. The present investigation evaluated the antimicrobial potential of edible medicinal oils of Cocos nucifera, Helianthus annus, Brassica juncea, Ricinus communis, Arachis hypogea, Glycine max, Gossypium hirsutum and  Sesamum indicum extracted from diff...

Nuzhat Tabassum and G.M. Vidyasagar *

Medicinal Plants and Microbiology Research Laboratory, Department of Post-Graduate Studies and Research in Botany, Gulbarga University, Gulbarga – 585 106, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4493-98

4493-4498

3240

1049

51.

ANTIUROLITHIATIC EFFECT OF VARIOUS WHOLE PLANT EXTRACT OF AGERATUM CONZOIDES LINN. ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE WISTAR ALBINO RATS

In present study antiurolithic activity of various extract of whole plant of Ageratum conzoides Linn was investigated on experimentally urolithiasis induced male albino wistar rats. Urolithiasis was induced in animals by using ethylene glycol (5% v/v, 2ml/rat/7days). Experimental induction of hyperoxaluria results in rapid formation of calcium oxalate crystals in the renal tubules of experimental ...

Soundararajan Muthukrishnan

Department of Pharmacology, Sankaralingam Bhuvaneshwari College of Pharmacy, Sivakasi, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4499-05

4499-05

1905

521

52.

CORRELATION BETWEEN URINARY MICROALBUMIN, GLYCOSYLATED HAEMOGLOBIN AND SERUM MAGNESIUM IN TYPE 2 DIABETIC PATIENTS

Background & objectives: - Diabetes mellitus comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. One of the leading causes of diabetes mellitus related morbidity and mortality is diabetic nephropathy. The earliest stage of diabetic nephropathy is Microalbuminuria, which is the excretion of extremely small quantities of albumin in the range of 30 - 300 mg/...

Anand Mishra*, Dhananjay Tiwari , Neha Sharma and Priyanka Thapa

Department of Biochemistry SRMS IMS, Bhojipura Bareilly, Uttar Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4506-08

4506-08

1388

590

53.

SYNTHESIS, PHARMACOLOGICAL ACTIVITY AND HYDROLYTIC BEHAVIOUR OF MUTUAL PRODRUGS OF IBUPROFEN

For reducing the gastrointestinal (GI) toxicity associated with ibuprofen (IBU), its carboxylic group was masked by synthesizing its mutual prodrugs with propyphenazone by direct coupling and by using spacer technique (amino acid was taken as a spacer).  The structures of synthesized prodrugs were confirmed by 1H-NMR, 13C-NMR, Mass and FT-IR spectral methods and their purity was established by el...

Sucheta , Sanju Nanda * and Dharam Pal Pathak

Department of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana-124001, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4509-21

4509-21

1602

600

54.

QUALITY OF LIFE IN PATEINTS WITH PSORIASIS IN OSMANABAD REGION OF INDIA: A SINGLE CENTRE STUDY

The prevalence of psoriasis has a deep negative impact on Quality of life (QoL) on daily basis. It has been classified under psycho physiological disorders. The prime objective of the present study is to evaluate and assess the Quality of Life (QoL) of psoriasis patients in Osmanabad region of India. A retrospective analyzing study was carried out on 52 psoriatic patients attending outpatient and ...

Shaikh Gazi * , Sadath Ali , Talmale S R , Sudhir Pange , Bhalchandra Kadam and Ulhas Surwase

Associate Professor, K T Patil College of pharmacy, P O Box no# 56, Siddhartha Nagar, Barshi road Osmanabad, Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4522-28

4522-28

1649

432

55.

DEVELOPMENT AND VALIDATION OF A HPLC-UV METHOD FOR SIMULTANEOUS DETERMINATION OF CEFTRIAXONE AND SULBACTAM IN POWDER FOR INJECTION FORMULATION

A simple, rapid, and sensitive high-performance liquid chromatographic method with UV detection has been developed and validated according to the ICH guidelines for the quantization of Ceftriaxone (CEF) and Sulbactam (SUL) in parenteral preparation. Chromatographic separation was carried out in a Hypersil GoldC8 column (250 mm × 4.6 mm; 5 μm particle size) of Thermo Scientific  with simple mobi...

Sarbojit Kundu*, Tapas Majumder, Prasanta Kumar Barat and Subrata Kumar Ray

Central Drugs Laboratory, (Govt. of India), 3, Kyd Street, Kolkata-700 016, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4529-34

4529-34

1989

497

56.

PRELIMINARY PHYTOCHEMICAL ANALYSIS AND THIN LAYER CHROMATOGRAPHY OF THE EXTRACTS OF EXCOECARIA AGALLOCHA L.

Purpose: The focus of the present paper was a preliminary phytochemical and TLC analysis of the various extracts (root, stem and leaf) of the mangrove plant Excoecaria agallocha L.  Methods: Phytochemical analysis was carried out using the standard phytochemical assays. TLC analysis of the petroleum ether and chloroform fraction of the leaves was carried out using the solvent system Toluene: Ethy...

M. Deepa* and C.K. Padmaja

Research Associate, SBST, VIT University, Vellore - 632014, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4532-42

4535-4542

4416

1517

57.

EFFECT OF DRUG RELEASE ON ALBENDAZOLE CHEWABLE TABLETS BY USING DIFFERENT FORMULATION TECHNIQUES

In this research study the effect drug release of albendazole chewable tablets has been determined. The drug release is calculated by using disintegration process which is directly related to with the hardness of tablets. The tablets are prepared by using three types of granulating methods are non-aqueous granulation, aqueous granulation and direct compression. The tablets are evaluated by calcula...

Kuchi Shishir Chandra Sharma , Y. Kranthi Kumar* and Kondeti Ranjith Reddy

Research Scholar, SSJ College of Pharmacy, Vattinagulapally, Hyderabad-75, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4543-47

4543-4547

3705

1051

58.

EVALUATION OF CHEMICAL CONSTITUENTS OF BUTEA MONOSPERMA (BARK)

From TLC examination of fractions of benzene and benzene: ether (5:5) extract of the stem bark of B. monosperma revealed the separable mixture. These fractions were subjected to rechromatography. Isolated compounds were purified and crystallized by chloroform: methanol. After isolation  and purification afforded white crystalline substance which was subjected to physical , chemical and spectral ...

Mustazi Jafri* and B.K. Mehta

School of Studies in Chemistry Vikram University, Ujjain – 456010, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4548-51

4548-51

1798

524

59.

IN-VITRO FREE-RADICAL SCAVENGING POTENTIAL OF THREE LIVERWORTS OF DARJEELING HIMALAYA

The present study was aimed to screen the antioxidant activity and phytochemical content of bryophyte species Marchantia paleacea Bertol., Marchantia linearis Lehm. & Lindenb. and Conocephalum conicum (L.) Underw. collected from Darjeeling hills of Eastern Himalaya, India. The free radical scavenging activities were measured in-vitro by DPPH radical, metal chelating, superoxide, ABTS+, reducin...

Sumira Mukhia , Palash Mandal*, D.K. Singh , Devendra Singh and Dibakar Choudhury

Plant Physiology and Pharmacognosy Research Laboratory, Department of Botany, North Bengal University, P.O: NBU, Raja Rammohunpur, District: Darjeeling, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4552-61

4552-61

1530

650

60.

QSAR STUDIES ON PPARγ AGONIST 2- ALKOXYDIHYDROCINNAMATES WHICH USE AS LEAD MOLECULE FOR THE SYNTHESIS OF NEW COMPOUNDS TO TREAT DIABETES AND NEUROLOGICAL DISORDER

Quantitative structure-activity relationships (QSAR) are based on the assumption that the activity of a certain chemical compound is related to its structure. More precisely, this approach says that the activity or the property is related to the chemical structure through a certain mathematical algorithm, or rule. Quantitative structure activity relationship (QSAR) analysis used to understand the ...

Ram Babu Tripathi*, Milind Pande and Gaurav Garg

Bioinformatics Lab, Department of Pharmacy, Mangalayatan University Beswan, Aligarh -202145, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4562-65

4562-4565

1725

341

61.

EXPERIMENTAL EVALUATION OF TIGECYCLINE AND TEIKOPLANIN IN THE TREATMENT OF IMPLANT RELATED METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) OSTEOMYELITIS

Treatment of implant related MRSA osteomyelitis is a real challenge both for the physician and the patient. We evaluated the comparative efficacy of tigecycline, a novel broad-spectrum glycycline antibiotic and the glycopeptide antibiotic teicoplanin in the treatment of implant related MRSA osteomyelitis in an experimental rat model. Implant related MRSA osteomyelitis was studied in tibial metaphy...

Zafer Orhan*, Erdem Değirmenci , Birhan Oktas , Okan Karaduman , Gözde Kır and Lütfiye Mülazımoğlu

Department of Orthopaedics and Traumatology, Duzce University, Duzce Medical School, 81620 Duzce, Turkey

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4566-73

4566-4573

1406

428

62.

ANTIOXIDANT ACTIVITY OF OPUNTIA FICUS-INDICA FLOWERS PHENOLIC EXTRACTS

The cactusplant Oputia ficus-indica, is a member of the cactaceae family, native to Mexico, mainly cultivated for its cladodes, flowers and fruits. Opuntia flower is useful in numerous fields; such as traditional medicines. Phenolic Flowers extracts of opuntia ficus-indica were phytochemical studied and in-vitro tested for their potential antioxydant activity using four methods, the total antioxid...

H. Dib*, M. Belarbi, M.C Beghdad and M. Seladji

Laboratory of Natural Products, Department of Biology, Faculty of Sciences of the Nature and the life, University of Tlemcen, Algeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).4574-82

4574-4582

2580

0