Pages Menu
TwitterRssFacebook
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

Categories Menu

Volume 4 (2013) - Issue 9, September

Review Articles

 
Title
Views
PDF
Cited
1.

BIOFILM INFECTIONS: A NEW THERAPEUTIC CHALLENGE

Biofilms are multicellular communities of bacteria. The ability to form biofilm is a universal attribute of bacteria and as bacteria can form biofilm in medical, industrial and environmental settings, it impacts human lives in many different ways. Bacteria undergo profound physiologic, morphologic and genetic changes as the transit from planktonic (free swimming, non-biofilm) form to surface attac...

Ashfaque Hossain

Department of Medical Microbiology, College of Medicine, University of Hail, PO Box.- 2440, Hail, Saudi Arabia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3286-95

3286-3295

1355

393

2.

A REVIEW ON ANTICONVULSANT ACTIVITY OF 1, 3-BENZODIOXOLE RING SYSTEM BASED COMPOUNDS

, 3-Benzodioxole ring system present in various naturally occurring molecules. Various synthetic molecules having 1, 3-Benzodioxole ring system have shown various biological activities. Stiripentol and Antiepilepserine are recently developed antiepileptic drugs which contain 1, 3-Benzodioxle rings system in core moiety. In the present work I have focused on the anticonvulsant activity of 1, 3-Benz...

Sagar Kumar

S.D. College of Pharmacy and Vocational Studies, Muzaffarnagar, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3296-03

3296-3303

1694

547

3.

A CRITICAL REVIEW ON ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES OF ALOE VERA L.

Medicinal plants form the backbone of traditional system of medicine in India. Biotechnological and Pharmacological studies have acknowledged the value of medicinal plants as potential source of bioactive compounds. Phytochemicals from medicinal plants serve as lead compounds in drug discovery and design. Medicinal plants are rich source of novel drugs that forms the ingredients in traditional sys...

Neelofar Khanam* and G.K. Sharma

Research Scholar, C/o.- Dr. G.K. Sharma (Associate Professor), Division of Biotechnology Department of Botany, Hindu College, Moradabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3304-16

3304-3316

2171

2542

4.

A REVIEW ARTICLE ON CLEANING VALIDATION

Pharmaceutical product and active pharmaceutical ingredients (APIs) can be contaminated by other pharmaceutical products or APIs, by cleaning agents, by microorganisms or by other materials e.g. air borne particle, dust, lubricants, raw materials, intermediates. Mainly cleaning is performed to remove product and non-product contaminating material. Ineffective cleaning can lead to adulterated produ...

D. Narayana Murthy and K. Chitra*

Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Chennai-600 116, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3317-27

3317- 3327

5634

1140

5.

HERBAL REMEDIES FOR NEURODEGENERATIVE DISORDER (ALZHEIMER’S DISEASE): A REVIEW

Alzheimer’s disease, a neurodegenerative disorder is characterized by intense memory loss enough to interfere with social and occupational execution.It is the most general form of dementia, affecting more than 20 million people worldwide. The treatments of Alzheimer's disease are through cholinesterase inhibitors or NMDA-receptor antagonists, while doubts remain about the therapeutic efficacy of...

Parul Agarwal*, Shashi Alok, Amreen Fatima and Prem Prakash Singh

Institute of Pharmacy, Bundelkhand University, Jhansi- 284121, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3328-40

3328-3340

5739

1145

6.

DOXORUBICIN INDUCED CARDIOMYOPATHY AND ITS HERBAL SOLUTION

Herbal medicines are represented as the most potential field of alternative medicines all over the world for a number of diseases in which allopathic medicines have no or little solution. For this reason, a large proportion of the Indian population for their physical and psychological health depends largely on traditional system of medicines. Doxorubicin is an anticancer drug used in the treatment...

Munish Garg* and Tinku Singhal

Department of Pharmaceutical Sciences, Maharshi Dayanand University Rohtak -124001, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3341-46

3341-3346

1842

565

Research Articles

 
Title
Views
PDF
Cited
7.

ENERGY SAVING BY MODIFICATION IN HVAC AS A COST SAVING OPPORTUNITY FOR INDUSTRIES

HVAC maintain both comfort and safety of indoor air quality. The challenge of maintaining high product quality while simultaneously reducing production costs can often be met through investments in energy efficient technologies and energy efficiency practices. The greatest opportunities for energy efficiency exist at the design stage for HVAC systems in new industrial facilities. By sizing compone...

Parth Patel

Kalol Institute of Pharmacy, Kalol, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3347-56

3347-3356

6927

710

8.

ALTERNATIVES TO Bt- BRINJAL

The Bt brinjal is a suite of transgenic Brinjals created by inserting a crystal protein gene (Cry1Ac) from the soil bacterium Bacillus thuringiensis into the genome of various brinjal cultivars. The dispute over Bt Brinjal still continues and a proper decision has not yet been reached neither by the Ministry of Environment and Forests nor by the general public and scientists. Currently farmers rel...

A.S. Patil* and V.A. Mane

K. K. Wagh, College of Agriculture Biotechnology, Nasik-03, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3357-62

3357-3362

1701

486

9.

ROLE OF PHYTOMEDICINES AND NEUTRACEUTICALS IN THE PREVENTION OF CHRONIC DISEASES

The past decade has witnessed intense interest in nutraceuticals in which phytochemical constituents have long-term health promoting or medicinal qualities. Secondary products have a variety of functions in plants; it is likely that their ecological function have some potential medicinal effects for humans. Between 1990 and 2020, deaths from non-communicable diseases and injury are expected to ris...

K. Girija* and R. Radha

Department of Food Science and Nutrition, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore- 641 043, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3363-68

3363-3368

1507

462

10.

A VALIDATED, STABILITY-INDICATING HPLC METHOD FOR THE DETERMINATION OF FELODIPINE AND ITS RELATED SUBSTANCES

An HPLC method was developed and validated to determine felodipine and related substances. A C18 column (5μm, 250 ×4.6 mm) was used for the separation at room temperature, with methanol: acetonitrile: water (50:15:35%, v/v/v) as the mobile phase at the flow rate of 1.0mLmin−1. The detection wavelength was 238 nm. The validation characteristics included accuracy, precision, specificity, lineari...

Liandong Hu *, Qiaofeng Hu and Na Gao

School of Pharmaceutical Sciences & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, No.180, WuSi Road, Baoding, 071002, PR China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3369-74

3369-3374

2102

493

11.

FORMULATION AND EVALUATION OF NATURAL PALM OIL BASED VANISHING CREAM

In present work, a new vanishing cream using a natural base from palm oil and palm kernel oil and standard vanishing cream using stearic acid were prepared. The creams were o/w emulsions containing suitable combination of oil phase and aqueous phase along with preservatives. Both creams were white, non-greasy and smooth on application. They were subjected to various parameters such as; pH, viscosi...

R.E. Ugandar* and K. Sakthy Deivi

Faculty of Pharmacy, Asia Metropolitan University (Formerly known as Masterskill University College of Health Sciences), G-8, Jalan Kemacahaya, Taman Kemacahaya, Batu 9, Cheras- 43200, Selangor, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3375-80

3375-3380

10265

1182

12.

PREPARATION AND EVALUATION OF SIMVASTATIN ORODISPERSIBLE TABLETS CONTAINING SOY POLYSACCHARIDE AND POTASSIUM POLACRILLIN AS NOVEL SUPERDISINTEGRANTS

Oral bioavailability of Simvastatin is very low (5%) due to bad solubility and effect of first pass. The aim of this work is to enhance its solubility and reformulating it as orodispersible tablet to overcome the two problems. Simvastatin solid dispersions in β- cyclodextrin, hydroxylpropyl-β-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios namely 1...

Khaled M. Hosny*, Ahmed Khames, and Seham S.Abd Elhady

Khaled M. Hosny*1, 3, Ahmed Khames 2, 3, and Seham S.Abd Elhady 1

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3381-89

3381-3389

2103

742

13.

XANTHAN GUM BASED ONCE A DAY MATRIX TABLET OF CEFIXIME TRIHYDRATE: DEVELOPMENT AND EVALUATION

The present study was an attempt to investigate the feasibility of the matrix based sustained release unit dosage formulation of cefixime trihydrate. Matrix tablets were prepared by using xanthan gum along with the other polymer combinations (Guar gum, sodium alginate and hydroxypropylmethyl cellulose). Effect of different formulation variables like polymer concentration, ratio of polymer combinat...

Nagendra Kumar , Rahul Tripathi , Gopal Nath and Brahmeshwar Mishra*

Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3390-99

3390-3399

1542

508

14.

EFFECT OF pH OF ENTERIC POLYER ON DISSOLUTION PROFILE OF DULOXETINE HCl DELAYED RELEASE PELLETS AT VARIOUS pH RANGES

The main objective of the present study is to evaluate the effect of pH of enteric polymer [methacrylic acid ethyl acrylate copolymer dispersion (Eudragit L30 D-55)], on dissolution profile of Duloxetine HCl delayed release formulation with the Tlag of 2hrs. The said formulation was formulated using fluidized bed process in three separate layers, the drug layer, the barrier layer and the enteric l...

Raja Subburayalu*, Janakiraman Kunchithapatham and Ramkumar Pillppan

Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3400-07

3400-3407

2829

1339

15.

SYNTHESIS AND BIOLOGICAL ASSESMENT OF QUINAZOLONE BASED AMIDE LINKAGE CONTAINING THIAZOLIDINONE AND THEIR DERIVATIVES

A number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A  Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4- (4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesi...

Bhavna Kandpal* and Jyotsna Meshram

Bhavna Kandpal*1 and Jyotsna Meshram 2

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3408-15

3408-3415

1336

412

16.

DEVELOPMENT AND VALIDATION OF NEW ANALYTICAL METHOD FOR THE ESTIMATION OF ATORVASTATIN CALCIUM HYDRATE RESIDUE BY USING UV SPECTROPHOTOMETER

A new, simple and sensitive spectroscopic method has been developed for the estimation of Atorvastatin calcium hydrate residue by using swabbing technique. In the proposed method the absorbance was measured 245.0nm corresponding to the absorbance maxima of Atorvastatin calcium in the ratio methanol and water as 90:10 as a solvent. Shimadzu-2450 UV-Visible spectrophotometer with UV Prove 2.31 softw...

S.K. Rath*, S.V. Samantaray and S.C. Dinda

Department of PA & QA, School of Pharmaceutical Education & Research, Berhampur University, Berhampur- 760 007, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3416-25

3416-3425

1723

652

17.

EFFECT OF ZINC AND VITAMIN A SUPPLEMENTATION ALONG WITH INTER-TUBERCULAR TREATMENT IN PULMONARY TUBERCULOSIS IN NORTH INDIAN PATIENTS

Tuberculosis is the major public health problem in throughout the world caused by Mycobacterium tuberculosis. Result indicates that micronutrient deficiency is common in patients with tuberculosis. As per in this study patients with newly diagnosed tuberculosis patients were divided into four groups. One group (n=41) received a placebo, second group (n=47) received 5000 IU vitamin A as retinyl ace...

Ibrahim A.M. Ginawi *, Mohammed Q. Ahmed , Irfan Ahmad and Awdah M. Al-Hazimi

Assistant Professor (Community Medicine),Vice Dean College of Medicine, University of Hail, Kingdom of Saudi Arabia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3426-31

3426-3431

1676

362

18.

SPREADING OUT OF ACECLOFENAC SUSTAINED RELEASE MICROCAPSULES BASED ON HPMC 50 CPS BY EMULSION SOLVENT EVAPORATION TECHNIQUE

Sustained released Aceclofenac microcapsules based on synthetic hydrophilic polymer hydroxypropyl methylcellulose (HPMC) were developed in this study in an attempt to design a dosage form that would manifest desirable release profile. W/O emulsion solvent evaporation technique was employed. Various release retarding agents were used to provide the analgesic and anti-inflammatory action of aceclof...

Md. Sium-Ul Hossain Miah*, Rishikesh, Md. Asraful Islam, Bibekananda Saha and Md. Mehedi Faysal

Department of Pharmacy, School of Medicine, University of Asia Pacific, Dhaka-1209, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3432-39

3432-3439

1423

431

19.

IN-VITRO AND IN-VIVO EVALUATION OF ANTIASTHMATIC ACTIVITY OF PICRORHIZA KURROA PLANT

Asthma isa disease of the human respiratory system. The ethanolic extract of the roots of Picrorhiza kurroa was evaluated for antiasthmatic activity by using in-vivo and in-vitro model in guinea pigs. Animal studies used the histamine induced broncho-constriction in guinea pigs. The extract showed a maximum degree of protection of 52.16 % which was comparable to that of salbutamol 65.83 %. The eff...

R. Sehgal*, A. Chauhan , U.K.Gilhotra and Aindry Gilhotra

Department of Chemistry, S. K. College, Sikar, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3440-43

3440-3443

1777

646

20.

IONTOPHORESIS OF FLUVASTATIN SODIUM: STUDY OF VARIOUS FACTOR AND IN-VITRO PERMEATION

Fluvastatin sodium (FVS) is the first fully synthetic 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitors used for the treatment of hypercholesterolemia. It shows extensive first pass metabolism with short plasma half-life (3 hrs). The iontophoresis approach was used to determine the permeability of drug through isolated rat skin. In-vitro permeation of drug was determined by using ...

C.J. Tank*, G.K. Kapse , J.I. Sarvaiya

PARTH’’, Vanganga Society, Timbavadi, Ta.Dist. – Junagadh, PIN – 362015, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3444-52

3444-3452

1434

420

21.

SALICYLIC ACID AND CHITOSAN MEDIATED ABIOTIC STRESS IN CELL SUSPENSION CULTURE OF ANDROGRAPHIS PANICULATA (BURM.F.) NEES. FOR ANDRO-GRAPHOLIDE SYNTHESIS

Quantitative and qualitative improvement of rare and valuable bioactive plant products is promisingly possible using In-vitro cell culture techniques. The present investigation was conducted with the aim to elicit the synthesis ofandrographolide by subjecting cultured cells of Andrographis paniculata to Salicylic acid (SA) and Chitosan mediated abiotic stressCell suspension culture of Andrographis...

Moinuddin M. Ali Vakil* and Vijay D. Mendhulkar

Department of Botany, The Institute of Science, 15, Madam Cama Road, Mumbai- 4000 32, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3453-59

3453-3459

1290

750

22.

PARTIAL PURIFICATION AND CHARACTERIZATION OF PROTEASE ENZYME FROM NOMURAEA RILEYI

Nomuraea rileyi (Farlow) Samson is an entomopathogenic fungus capable of producing a variety of enzymes including proteases and chitinases. Protease derived from microorganisms such as fungi, bacteria, and yeast has established wide spread applications in fields such as in the food, detergent and other industries. This study investigates the strategy for partial purification and characterization o...

N. Ramachandran and R. Arutselvi*

Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3460-65

3460-3465

2316

470

23.

PRECLINICAL EFFICACY AND SAFETY OF HERBAL FORMULATION FOR MANAGEMENT OF WOUNDS

Background: Medicinal plants in Tripathi hills and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products developed by local herbalist and sold to the public are not standardized and lack efficacy and safety data to support use. Objective: to evaluate the medicinal plants...

K. Hemamalini*, and Anurag Bhargava

Institute of Pharmaceutical sciences and Research Centre, Bhagwant University, Ajmer, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3466-70

3466-3470

1464

432

24.

ROLE OF ACUTE PHASE PROTEINS STATUS IN CHRONIC ALCOHOLIC LIVER DISEASES

Back ground: Alcoholic cirrhosis is a condition of irreversible liver disease due to the chronic inflammatory and toxic effects of ethanol on the liver. Acute alcoholic hepatitis occurs in habitual drinkers, often a period of increased alcohol intake. Although, the clinical features may mimic acute viral hepatitis. Progression of liver fibrosis to cirrhosis is dangerous as well as potentially life...

IJPSRN. Santhosh Kumar*, K. Balu Mahendran , Mohammad Anwar , K.N. Kalaivanam R. Bheemasen and E. Gnana Desigan

Ph. D scholar, Division of Biochemistry, Rajah Muthiah Medical College, Annamalai University, Annamalai nagar-608002, Tamil Nadu, India

DOI: p://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3471-76

3471-3476

1309

442

25.

EVALUATION OF ANTI-OXIDANT, ANTI-INFLAMMATORY AND CYTOTOXICITY POTENTIAL OF HEMIGRAPHIS COLORATA

Plants have been used as a source of natural products for various therapeutic processes from a long time. The proposed work illustrates the study of the importance of natural products in terms in-vitro approaches. On account of this study the phytochemical constituents of various extracts of Hemigraphis colorata (Blume) are evaluated. The plant was traditionally known for its wound healing activit...

T.T. Akhil* and Punieethaa Prabhu

Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode- 637 215, Nammakkal, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3477-83

3477-3483

1872

1327

26.

FORMULATION DEVELOPMENT AND EVALUATION OF ORAL THIN FILMS- DIPHEN HYDRAMINE HCl

The aim of this study was to develop a fast releasing oral polymeric thin film, prepared by solvent casting method, with good mechanical properties, instant disintegration and dissolution. Diphenhydramine hydrochloride, an antihistamine drug belonging to BCS class I was used for oral thin film preparation. The formulations from the preliminary trial were analyzed which was applied to optimize the ...

S. Aruna Jyothi*, P. Mounika, S. Vineesha, Suraiya Mehdia and N. Arun Dutt

St. Marys College of Pharmacy, Secunderabad-500025, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3484-88

3484-3488

3313

1041

27.

FORMULATION AND EVALUATION OF DOMPERIDONE FAST DISSOLVING TABLETS USING PLANTAGO OVATA MUCILAGE

The present investigation deals with development of fast dissolving tablets of Domperidone to produce the intended benefits. Domperidone is an antiemetic and a prokinetic medicine. Domperidone is water insoluble drug with problems of variable bioavailability and bio-inequivalence. As precision of dosing and patient’s compliance become important prerequisite for quick relief from emesis, there is...

Ravi Subhashini* and D. Ramesh Reddy

Department of Pharmaceutics, Vishwa Bharathi College of Pharmaceutical Sciences, Perecherla (V) (M),Guntur (Dt)-522009, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3489-93

3489-3493

2826

619

28.

ISOLATION, CHARACTERIZATION OF DEGRADATION PRODUCTS OF SITAGLIPTIN AND DEVELOPMENT OF VALIDATED STABILITY-INDICATING HPLC ASSAY METHOD FOR SITAGLIPTIN API AND TABLETS

The degradation pathway of sitagliptin in bulk and tablet has been investigated during stress study. Major degradation products were isolated in pure form and characterized using mass and NMR spectroscopy. Three previously unreported impurities were found to be, 3-(trifluoromethyl)-6, 7-dihydro[1,2,4]triazolo[4, 3-a]pyrazin-8(5H)-one, (2E)-1-[3-(trifluoromethyl)-5, 6-dihydro[1, 2, 4]triazolo[4, 3-...

Dnyaneshwar P. Sonune and Mahesh Kumar Mone*

Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Rajiv Gandhi Infotech Park, Phase-I, Hinjewadi, Pune-411 057, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3494-03

3494-3503

4394

2066

29.

COMPARATIVE STUDY OF OVERLAPPING GENES IN THE GENOMES OF MYCOPLASMA HOMINIS AND MYCOPLASMA PENETRANS

Overlapping genes are pairs of adjacent genes whose coding regions are partially or entirely overlapping. Overlapping genes in prokaryotes are a means to minimize genome size and increase the density of genetic information. Overlapping genes play an important role in genome reduction of Mycoplasmas during the course of their degenerative evolution. In this study overlapping genes in the genomes of...

Kandavelmani Angamuthu* and Shanmughavel Piramanayagam

Research and Development Centre, DBT Bioinformatics Facility, Department of Bioinformatics, Bharathiar University, Coimbatore – 641046, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3504-17

3504-3517

1529

387

30.

COMPARATIVE STUDY OF IMMUNOMODULATORY ACTIVITY OF OCIMUM SPECIES IN MICE

Aim: To compare the immunomodulatory effect of Ocimum sanctum and Ocimum basilicum in mice. Methods: Acute oral toxicity test was performed as per OECD -23 guidelines. Maximum dose level of 2000 mg/kg was selected for toxicological evaluation. Delayed type hypersensitivity reaction were carried out for assessment of cell mediated immune functions Result: Administration of Ocimum sanctum and ...

R. Caroline Jeba* and G. Rameshkumar

Department of Industrial Biotechnology, Dr. M. G. R Educational and Research Institute University, Maduravoyal, Chennai-600 095, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3518-23

3518-3523

1631

395

31.

PHARMACOGNOSTIC, PHYTOCHEMICAL AND PHYSICOCHEMICAL STUDIES OF ALLIUM SATIVUM LINN. BULB (LILIACEAE)

Allium sativum linn (Garlic) belong to family Liliaceae has been widely known since ancient times for medicinal use and for flavouring food. It contains large amount of sulphur containing compounds like Alliin, Allicin, Ajoene, Diallyl sulphide, Diallyl disulphide Diallyl trisulfide, Vinyldithiines which has beneficial activity including Antithrombotic, Anticancer, Antiviral, Antifungal and Antimi...

P.V. Kadam*, K.N. Yadav, F.A. Karjikar, F.A. Patel, M. K. Patidar and M.J. Patil

Marathwada Mitra Mandal’s College of Pharmacy, Thergaon (Kalewadi), Pune- 411 033, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3524-31

3524-3531

2015

2344

32.

DESIGN OF QUINOLONE DERIVATIVES AS POTENTIAL ANTIBACTERIAL USING MOLECULAR DESCRIPTORS

In the present work in mathematical modeling, quantitative structure activity relationship (QSAR) studies were performed on some quinolone derivatives as a potential antibacterial agent using statistical work. The regression analysis of the data has shown that the activities of the compound can be modeled excellently in bi-parametric model.A heurisimatedtic algorithm selects the best multiple line...

Kumar Nandan

Department of Chemistry, T.N.B. College, T. M. Bhagalpur University, Bhagalpur- 812007, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3532-35

3532-3535

1212

413

33.

FORMULATION AND IN-VITRO RELEASE OF POMEGRANATE PEELS’ POLYPHENOLS MICROBEADS

Sodium alginate and combinations of sodium alginate-pectin were used to study the effect on the loading efficiency and the radical scavenging activity of the polyphenols extracted from pomegranate peels (Punica granatum). The results indicate that the polyphenol content was less when the microbeads were prepared with a single type of polymer in comparison of the microbeads prepared with two types ...

W. Zam*, G. Bashour , W. Abdelwahed and W. Khayata

Department of Analytical and Food Chemistry, Faculty of Pharmacy, University of Aleppo, Syrian Arab Republic

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3536-40

3536-3540

1544

639

34.

AMPLIFICATION AND SEQUENCING OF MITOCHONDRIAL DNA (HVR-I) EXTRACTED FROM 1200 YEARS OLD HUMAN BONE SPECIMEN

Ancient DNA help in better understanding the evolution and migration pattern of humans throughout the world. The present work is a preliminary effort, to extract and amplify the ancient DNA from human bone samples provided by the Anthropological survey of India collected from the Himalayan region in 1952.  Many technical difficulties arise during DNA extraction, PCR amplification and sequencing w...

Rajeev Kumar Pandey, Deepankar Pratap Singh , Abid Ali 5, G Sudhakar and V.R. Rao*

Professor, Department of Anthropology, University of Delhi, North Campus, Delhi – 110007, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).1000-06

3541-3547

1723

387

35.

EVALUATION OF MARINE ALGAE KAPPAPHYCUS ALVAREZIL AS A SOURCE OF NATURAL PRESERVATIVE INGREDIENT

Marine organisms possess an inexhaustible source of useful chemical substances for the development of new drugs. The present project focused to identify the bioactive compounds from the seaweed Kappaphycus alvarezii. The experimental samples were collected from the sea coast of Rameshwaram, Tamil Nadu, in the form of fresh living sample. The fresh solvent extracts of K. alvarezii were found to be ...

G. Renuga*, Ali Osman and A. Babu Thandapani

Ultra College of Pharmacy, Department of Pharmaceutical Biotechnology, Madurai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3548-55

3548-3555

1941

763

36.

EVALUATION OF THE HAEMATOLOGICAL AND BIOCHEMICAL EFFECTS OF AVERON®, A HERBAL FORMULATION, AGAINST CYCLOPHOSPHAMIDE-INDUCED IMMUNOMODULATED MALE RATS

The study was carried out to evaluate the immunomodulatory activity and the effect on the biochemical parameters of Averon®, an herbal formulation, on cyclophosphamide induced immunosuppression in rats.  Haematological and biochemical parameters were evaluated after 21 days on blood samples collected by retro-orbital puncture at sacrifice. Results showed that death occurred in the immunosuppress...

G.E. Ukpo*, T.S. Ehianeta , A.Y. Adegoke and O.A. Salako

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, P. M. B 12003, Lagos, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3556-62

3556-3562

1525

831

37.

ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT OF THE AQUEOUS METHANOLIC AND PET-ETHER EXTRACT OF THE LEAVES OF MESUA FERREA

The purpose of the study is to evaluate the antimicrobial and cytotoxic activity of methanolic and pet-ether extract of leaves of Mesua ferrea. The antimicrobial activity was investigated against eight pathogenic Gram-positive and Gram-negative bacterial species at three concentrations (100, 300, 500 µg/disc) by using disc diffusion method. Both extracts showed moderate antibacterial activity aga...

H.M. Arif Ullah*, Syed Mohammed Tareq , Irfanul Huq , Muhammad Borhan Uddin and Md. Salauddin

Lecturer, Department of Pharmacy, North South University, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3563-68

3563-3568

1347

355

38.

QUALITY ASSESSMENT OF UNANI POLYHERBAL FORMULATION “HABB-E-AZARAQI” BY CONTEMPORARY SCIENTIFIC PARAMETERS

Demand of the Unani herbal drugs is becoming universal as the people are becoming more and more cognisant about the natural benefits of medicines with plant origin. Herbal drugs being easily affordable are becoming the first preference for the common man over purchasing the expensive modern pharmaceuticals. The WHO estimates that 80% of the world population rely on the medicines of plant origin fo...

Shazad Yaqub*, Mohd. Aftab , Mohd. Asif and Peerzada Yasir Yousuf

Department of Ilmul-Advia, Faculty of Medicine (Unani) , Jamia Hamdard, New Delhi, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3569-74

3569-3574

2875

704

39.

FORMULATION AND IN VITRO EVALUATION OF SALBUTAMOL SULPHATE SUSTAINED RELEASE TABLET BY USING FLOATING DRUG DELIVERY TECHNOLOGY

The present study involves in the preparation and evaluation of floating tablets of Salbutamol sulphate by direct compression method by using the hydrophilic polymer such as hydroxy propyl methyl cellulose (HPMC), Sodium carboxy methyl cellulose, Dextrin and Carbopol. Sodium bicarbonate, Tartaric acid and citric acid were incorporated as gas generating agent. The study aims to achieve different fo...

Arup Ratan Deb*, Padmakana Malakar , Nilufa Yeasmin and Siraj Ahmed

Department of Pharmaceutics, Moonray Institute Pharmaceutical Sciences , Mahbubnagar, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3575-81

3575-3581

2279

486

40.

MOLECULAR CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF OCTOPUS AEGINA AND OCTOPUS DOLFUSII IN GULF OF MANNAR COAST

Antibacterial activity and protein content was studied in two species of octopus belonging to the family Octopoda. The highest zone of inhibition of about 34mm and 28mm were obtained against Vibrio parahaemolyticus and theprotein content was 107.16µg/L and 136.20µg/Lin Octopus dolfusii and Octopus aegina, respectively. SDS profile revealed bands of molecular weight of about 32.83 KDa to 72.36 KD...

S. Monolisha*, Aswathi Elizabeth Mani, Jamila Patterson and J.K. Patterson Edward

Suganthi Devadason Marine Research Institute, Tuticorin, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3582-87

3582-3587

1586

543

41.

NEW POTENTIAL ANTIMALARIAL AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASE LIGAND AS ANTIMALARIAL AGENTS

Plasmodium falciparum is the protozoan parasite responsible for the majority of life-threatening cases of human malaria, causing more than one million deaths a year. The global emergence of drug-resistant malarial parasites necessitates identification and characterization of novel drug targets. At present, α-carbonic anhydrase (CA) genes are identified in limited numbers of parasites in both prot...

Gopal Garg*, Ashish Acharya and Kuldeep Patel

VNS Institute of Pharmacy, Ratibad road, Bhopal- 462031, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3588-95

3588-3595

1702

441

42.

ISOLATION OF TRITERPENES FROM FIORIA VITIFOLIA (L.) AND IT’S ANTIOXIDANT ACTIVITY

Fioria vitifolia L. (Linn.),(Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also used as an immune system booster. The methanolic extract of whole plant of Fioria vitifolia was taken underphytochemical investigation. The methanolic extract was partitioned with different solvent system by increasing their polarities u...

K. Mahalakshmi*, N. Senthilkumar , P. Solairaj and K.G. Parthiban

Prist University, Thanjavur, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3596-00

3596-3600

1449

690

43.

STRUCTURE MODIFICATION OF RITONAVIR WITH CARBAZOLE; SYNTHESIS AND CHARACTERIZATION

The core moiety of ritonavir (2S, 3S, 5S)-5-(tert-butyloxycarbonyl)amino-2-amino-3-hydroxy-1,6-diphenylhexane (7) on condensation with oxirane of carbazole (8) in isopropyl alcohol at reflux and deprotected with mineral acid gave compound 10. Coupling of compound 10 with carbamate amino acid (11a-15c) in the presence of EDAC.HCl and HOBt at room temperaturegave ritonavir analogues containing carba...

V. Pandu Ranga Rao*, N. Senthil Kumar , Shankar B. Reddy , Aminul Islam and B. Hari Babu

Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Medak District-502329, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3601-07

3601-3607

1485

572

44.

IN-VITRO ANTIOXIDANT ACTIVITY AND DETERMINATION OF TOTAL PHENOLIC, FLAVONOID CONTENTS OF STEMS OF ROTULA AQUATICA LOUR.

This research aims to detect the in-vitro antioxidant activity of the methanolic and aqueous stem extract of Rotula aquatica lour and to estimate its phenolic and flavonoid content. DPPH (2, 2-diphenyl-1-picryl hydrazyl), superoxide radical scavenging capacity and reducing power assay (RPA) were carried out to evaluate in vitro antioxidant activity. Phytochemical screening was carried out accordin...

Bhnu Priya*, Sarika R. Zade , Anish Shaikh, Manoj Gahlot and Punam Joshi

Department of Pharmaceutical Chemistry, Sitabai Thite College of Pharmacy, Shirur, Pune-412210, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3608-14

3608-3614

1432

473

45.

MICROWAVE-ASSISTED RAPID GREEN SYNTHESIS OF SILVER NANOPARTICLES USING SARACA INDICA LEAF EXTRACT AND THEIR ANTIBACTERIAL POTENTIAL

The present study reports an environmentally friendly, microwave-assisted rapid green synthetic method using Saraca indica leaf extract makes a fast and convenient method for the synthesis of silver nanoparticles and can reduce most of the silver ions into silver nanoparticles within 180 sec of reaction time with the aid of microwave. The synthesized nanoparticles were characterized using UV-visib...

Seema Garg

Amity Institute of Applied Sciences, Amity University, Noida, 201301, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3615-19

3615-3619

1615

676

46.

SYNTHESIS, CHARACTERISATION AND ANTIFUNGAL STUDIES OF Cu (II) HALIDE COMPLEXES OF SOME STERYL DERIVATIVES OF SUBSTITUTED BENZIMIDAZOLES

Complexes of Copper (II) halides with steryl derivative of 2- methylbenzimidazole (stmbz), 2-ethylbenzimidazole (stebz) and 2-benzylbenzimidazole (stbbz) of composition CuL2X2 (L = stmbz, stebz and stbbz and X = Cl, Br) have been prepared and characterised. The magnetic susceptibility e.p.r. data, electronic absorption pattern and i.r. spectral studies of complexes indicated distorted octahedral e...

L.K. Mishra* and Madhu Bala

Professor, Department of Chemistry (Retd.), Patna University, Patna- 800 005, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3620-24

3620-3624

1110

510

47.

SCREENING AND ISOLATION OF FIBRINOLYTIC PROTEASE PRODUCING MESOPHILIC BACTERIA FROM SLAUGHTER HOUSES IN BANGALORE

This work has been undertaken for the screening and isolation of fibrinolytic protease producing mesophilic bacteria from ten soil samples, collected from slaughter housesvarious regions of Bangalore and used to screen for fibrinolytic protease production by using fibrin plate assay. In  the  present  study,  an  attempt  was  made  to  isolate  efficient  fibrinolytic protease producin...

E. Venkata Naga Raju* and G. Divakar

Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur- 522 510, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3625-29

3625-3629

1918

1122

48.

LIQUID CHROMATOGRAPHIC SEPARATION AND ANALYSIS OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL FORMULATIONS

An accurate, simple and precise RP-HPLC method for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical formulations was developed and validated. Chromatographic separation of two drugs was achieved on a Kromasil C18, (250x4.6nm, 5µm) column by using the mobile phase consisted of methanol, tetrahydrofuran and water in the ratio 55:05:40 at a flow rate of 1mL/min...

Krishna Veni P.R. , Jyothi K. Kasthuri , A. Vasu Babu , K. Vijay , G.V. Raman , I.E. Chakravarthy , B. Hari Babu*

Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur-522510, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3630-34

3630-3634

1574

511

49.

VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF DICLOFENAC DIETYLAMINE

Simple, sensitive and convenient spectrophotometric methods (method A and method B) are developed for the determination of diclofenac diethylamine (DDEA) in pure form and in formulations. Method A is based on the oxidation of drug by Fe(III) followed by the complex formation between reduced form of Fe(III) with 1,10-phenantroline. The resulting red colored chromogen is measured at 510 nm. Method B...

Divya Kumble, Narayana Badiadka* and Sapnakumari Majal

Department of Post Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka, India

DOI: 26 August, 2013

3635-3640

1428

1846

50.

INCIDENCE AND COMPARATIVE ANALYSIS OF ADVERSE DRUG REACTIONS IN DOTS

To assess the adverse drug reactions (ADRs) induced by antitubercular drugs used in Directly Observed Treatment Short Course (DOTS) from previously reported 8 articles from referred sources. Articles related to adverse drug reactions induced by first line anti- tuberculosis drugs in DOTS therapy published during 2002 to 2012 were searched. The incidence rate of each type of ADR from entire ADRs we...

Amitkumar Anandrao Khade* and Vishal Janu Gothal

Government College of Pharmacy, Karad, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3641-44

3641-3644

1338

414

51.

ANTIFERTILITY EFFECT OF AQUEOUS EXTRACT OF INDIGOFERA TRIFOLIATA LEAVES ON REPRODUCTIVE ABILITIES OF FEMALE ALBINO RATS

The present work deals with antifertility effect of the aqueous extract of Indigofera trifoliata leaves in female albino rats. Pregnant rats weighing 120 to 200 gm were randomized into 4 groups. From day 11 upto day 15 of pregnancy, rats were laprotomised on 10th day of pregnancy and live fetuses were observed in both the horns of the uterus. Rats in group 1 (control) were orally administered, wit...

Dinesh Dabhadkar, Varsha Zade* and Vaibhao Thakare

Department of Zoology, Government Vidarbha Institute of Science and Humanities, Amravati- 444 604, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3645-52

3645-3652

1565

602

52.

A COMPARATIVE STUDY OF ANTIDIABETIC EFFECT OF BROMOCRIPTINE AND METFORMIN IN ALLOXAN-INDUCED DIABETIC RATS

Bromocriptine mesylate quick release formulation has recently been approved by FDA for the treatment of diabetes mellitus. Till now it has been mainly known for its use in Parkinsonism and for suppression of lactation. Present study evaluates and compares the antihyperglycemic effect of the combination of bromocriptine and metformin with either of the two drugs taken alone. For this fasting blood ...

Anuj Kumar Pathak*, Praveen Kumar Sinha and Janardan Sharma

Department of Pharmacology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3653-58

3653-3658

1853

510

53.

IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF AQUEOUS LEAF EXTRACT OF PLANTS NEAR THERMAL POWER PLANT, METTUR, SALEM

The present study was undertaken to know about the free radical scavenging activity of plants located near Thermal power plant, Mettur, Salem. In this study, Polyalthia longifolia, Derris indica, Holopetela integrifolia, Tamarindus indica, Terminalia tomentosa, Psidium guajava, Nerium indicum, Azadirachta indica, Calotropis gigantea, Ricinus communis, Carica papaya, Ficus benghalensis, Embilica of...

M. Krishnaveni*, S. Durairaj, P. Madhiyan, L. Amsavalli and R. Chandrasekar

Department of Biochemistry, Periyar University, Salem, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3659-62

3659-3662

1452

477

54.

ETHNO ANTI DIABETIC PLANTS USED BY A FEW TRIBES OF RURAL KAMRUP DISTRICT, ASSAM

Kamrup District of Asasm is bounded by Udalguri and Baksa districts in the north, Meghalaya in the south, Darrang and Kamrup Metropolitan in the east and Goalpara and Nalbari district in the west. The rural part of kamrup district is mostly inhabitated by different tribes such as Boro, Khoronia Kochari, Rajbonghi, and Nepalis. An ethno botanical survey was conducted during the year 2011-2012 in so...

Jayashree Dutta* and M.C. Kalita

Department of Biotechnology, Gauhati University, Guwahati- 781 014, Assam, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3663-69

3663-3669

2484

468

55.

FORMULATION AND EVALUATION OF DOMPERIDONE ORODISPERSIBLE TABLET

Emesis is a clinical condition which requires immediate treatment. The present work is aimed to formulate Orodispersible Tablet (ODT) of BCS class II drug Domperidone using Kyron T-314 as superdisintegrant and Avicel 102 as disintegrant by direct compression method. The drug-excipients compatibility study was carried out by Fourier Transform Infrared (FTIR) and Differential Scanning Calorimetry (D...

R.B. Nawale and K.P. Mohite*

Department of Pharmaceutics, Government College of Pharmacy, Opposite Government Polytechnic, Osmanpura, Aurangabad 431005, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3670-77

3670-3677

2781

858