Volume 5 (2014) - Issue 6, June
Review Articles
MALE INFERTILITY: CAUSES AND CONTRIBUTORS
Male infertility is a reproductive health disorder, emerging globally as serious medicaland social problem that results in much trauma, emotional instability and psychological stress of the affected couples. In 50% of the diagnosed cases of infertility males are reported to be the predominant causative factor. Male infertility can assess by the quality and quantity of sperm cells as well as struct...
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THIRD GENERATION MATERIALS FOR WOUND DRESSINGS
An ideal wound Dressing need to be redefined based on the nature of wound and wound classifications. Since generations, wound have been defined as self-healing process, but chronic wounds and other wound requires handling and care from different parameters like moist conditions, biocompatibility, microbial infection to mention a few. Traditional methods have been continuously worked upon to delive...
14978
2406
CASSIA FISTULA LINN: A REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES
Cassia fistula Linn. (Family: Caesalpinaceae), commonly known ‘Sonali’ or ‘Bandarlati’, has been used in different traditional system of medicines for various ailments since ancient times. Cassia fistula grows throughout in Bangladesh and in many other Asian countries such as India, China, Hong Kong, Philippines, Malaysia, Indonesia, and Thailand. This article aims to provide a comprehensi...
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THERAPEUTIC POTENTIAL OF WITHANIA SOMNIFERA: A REPORT ON PHYTO-PHARMACOLOGICAL PROPERTIES
Withania somnifera belongs to the Solanaceaefamily, commonly known as Ashwagandha, Indian ginseng or Winter cherry. It is an important commercial medicinal crop, considered as similar to Panax ginseng in Chinese medicine. Different parts of this plant are used in traditional medicine for the treatment of various ailments. It provides defense against diseases, adverse environmental factors and help...
11755
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GELATIN NANOPARTICLE: PREPARATION, CHARACTERIZATION AND APPLICATION IN DRUG DELIVERY
Nanotechnology plays an important role in advanced biology and medicine research particularly in the development of potential site-specific delivery systems with lower drug toxicity and greater efficiency. In terms of nanopharmaceutics, gelatin was already considered as interesting biodegradable base material in the early days of particle development. The interest was based on the facts that gelat...
19215
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2-AMINO-3-CYANOPYRIDINE: A BIOACTIVE SCAFFOLD
One of the most fascinating branches of pharmaceutical field is the chemistry of heterocyclic molecules. Heterocyclic compounds are widely distributed in nature and have biological and industrial significance. Already most of the drugs available in the market are heterocyclic in nature. Cyanopyridine, a structural motif is a cause of concern for biologist and chemist in last twenty years. Specific...
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NANOROBOTS: A REVIEW
Nanomedicine offers the prospect of powerful new tools for the treatment of human diseases and the improvement of human biological systems. Nanomedicine is the process of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. Nanomedicine's nanorobots are so...
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Research Articles
CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF ESSENTIAL OILS FROM THE LEAVES OF OCIMUM BASILICUM L. AND OCIMUM GRATISSIMUM L. (LAMIACEAE)
Ocimum basilicum L. and Ocimum gratissimum L. (Lamiaceae) are widely distributed aromatic herbs used in ethnomedicinal management of a range of inflammatory disorders. In the present work we evaluated the topical anti-inflammatory effects of the volatile constituents extracted from the fresh leaves of these plant species. Fresh leaves of the plants were subjected to hydro distillation to obtain th...
9452
2088
THE ASSOCIATION BETWEEN SHISTOSOMIASIS AND ENTERIC FEVER IN A SINGLE SCHISTOSOMA ENDEMIC AREA IN SUDAN
Schistosomiasis is a major communicable disease with a great impact on both public health and socioeconomic status of the developing world.It is highly prevalent in tropics and causes morbidity and mortality in developing countries including Sudan. Because of its chronicity and robust immunomodulatory activity, the effects of Schistosomiasis on other diseases such as allergies, autoimmunity and in...
5476
1426
TRIDAX PROCUMBENS ATTENUATES ACETAMINOPHEN – INDUCED FREE RADICAL REACTION AND CELL NECROSIS IN CULTURED MOUSE HEPATOCYTES
Drug-induced hepatotoxicity represents a major clinical problem and an impediment to new medicine development. In vitro evaluation of hepatotoxicity is an essential stage in the research and development of new pharmaceuticals as the liver is one of the most commonly impacted organs during preclinical toxicity studies. The effect of an aqueous leaf extract of Tridax procumbens was evaluated...
2802
1031
EVALUATION OF DRUG PRESCRIBING PATTERN UNDER THE NATIONAL HEALTH INSURANCE SCHEME IN RURAL GHANA
Inappropriate prescription and use of drugs is a major public health concern worldwide especially in developing countries and account for huge national health budgets. The objective of this study was to evaluate prescribing pattern of drugs under the national health insurance scheme in a rural and peri-urban setting using the World Health Organization prescribing indicators and to establish determ...
3695
1231
PRELIMINARY PHYTOCHEMICAL, ANTIOXIDANT AND CYTOTOXICITY STUDY OF THE ETHANOLIC EXTRACTS OF PHYLLANTHUS ACIDUS L. ROOT BARK
Traditional medicine plays a very important role in Bangladesh, particularly at the primary health care level. The modern types of traditional medicine, namely, the Ayurvedic and Unani medicines are now officially recognized in Bangladesh .The objective of the present study was to evaluate antioxidant potential and cytotoxicity of ethanolic extract of root bark of Phyllanthus acidus L. The phytoch...
3840
1288
NIGELLA SATIVA AMELIORATES OXIDATIVE STRESS INDUCED BY DIETHYL PHTHALATE – AN IN VITRO STUDY
The present experiment was designed to assess oxidative stress, if any, caused by diethyl phthalate and its amelioration by Nigella sativa seed extract. For this, the liver and kidney homogenates were treated with different concentrations (10-40 µg/mL) of DEP with or without Nigella sativa seed extract. Lipid peroxidation, a marker for oxidative stress along with total protein content was analyze...
2774
1143
ANTIBACTERIAL ACTIVITY OF SIX MEDICINAL PLANTS USED IN TRADITIONAL MEDICINE GROWING IN BANGLADESH
The antibacterial activity of the hexane, methanol, and water extracts of Tamarindus indica, Azadirachta indica, Cucumis sativus, Eucalyptus camaldulensis, Switenia mahagoni, and Psidium guajava extensively used in traditional medicine were investigated. The disc diffusion assay method was used for the evaluation of the antibacterial activity of these extracts against 11 bacteria species. Kanamyci...
4556
1407
EVALUATION OF NOOTROPIC ACTIVITY OF HYDROXYCITRIC ACID IN PHENYTOIN TREATED RATS
The present study investigates neuroprotective effect of hydroxy citric acid (50%) on phenytoin induced cognitive impairment and oxidative stress in rats.Male Wistar rats were divided into 6 groups and each group received vehicle, phenytoin (25mg/kg, i.p) and hydroxy citric acid (400 and 800mg/kg, orally) for 14 days respectively. Memory and learning was evaluated by using the Rectangular maze, Mo...
3987
1400
EVALUATION OF IN VITRO ANTIOXIDANT ACTIVITY OF FLOWERS OF BLEPHARIS MOLLUGINIFOLIA
The objective of this study was to characterize the non-enzymatic and enzymatic antioxidants and Scavenging activities of different extracts (Petroleum ether, Benzene, Chloroform, Acetone, Ethanol, Methanol and Water) of dried flowers powder of Blepharis molluginifolia (Acanthaceae). Enzymatic antioxidant activity such as Superoxide Dismutase, Glutathione –S-transferase, peroxidase and Catalase ...
3965
1817
STABILITY-INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CEFDINIR IN PURE FORM AND PHARMACEUTICAL PREPARATION
Three Simple, rapid, sensitive, accurate and precise stability-indicating spectrophotometric methods was developed for the determination of cefdinir in bulk powder and in pharmaceutical preparation. Method (A) Ratio derivative method(1DD); is used for the determination of intact cefdinir in presence of its degradation product at 307 nm in the range of 2 – 14 µg ml-1 with LOD of 0.049 µg ml-1...
3369
1129
ANTIPROLIFERATIVE ACTIVITY OF TRAPA ACORNIS SHELL EXTRACTS AGAINST HUMAN BREAST CANCER CELL LINES
Evaluation of the anticancer effect of Trapa acornis (Family- Trapaceae) which has long been prescribed for various infectious and malignant diseases. The shells extract of Trapa acornis has been carried out by following due procedure. Cell lines, cultures were incorporated and procured for in-vitro and in-vivo study with reference to cell proliferation assay, cell viability assay and cell cycle a...
2848
1050
FORMULATION AND IN-VITRO EVALUATION OF FLOATING TABLETS OF HYDROXYPROPYL METHYLCELLULOSE K4M AND CARBOPOL-934P USING METRONIDAZOLE AS A MODEL DRUG
In the present study, metronidazole was used for preparing floating dosage forms that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. Hydroxypropyl methylcellulose (HPMC K4M) and Carbopol-934P of different ratio were used to prepare Hydrodynamically Balanced Systems (HBS) by d...
4832
1182
DEVELOPMENT AND EVALUATION OF HERBAL FORMULATION FOR THE TREATMENT OF ACNE
Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. Staphylococcus aur...
15416
4708
EVALUATION OF ALPHA – AMYLASE AND ALPHA – GLUCOSIDASE INHIBITORY ACTIVITIES OF RHIZOPHORA MUCRONATA
Rhizophora mucronata Lam. belongs to mangrove plants and antidiabetic activity is one of the traditional uses of R. mucronata. One of the anti-diabetic therapeutic strategies is inhibition of carbohydrate digesting enzymes such as alpha-amylase and alpha-glucosidase. Hence in the present study, 2 extract namely, aqueous and ethanol of Rhizophora mucronata Lam. were evaluated for their effect on ...
6458
1841
ANTIHYPERGLYCEMIC AND ANTIOXIDANT POTENTIALS OF SESBANIA GRANDIFLORA LEAVES STUDIED IN STZ INDUCED EXPERIMENTAL DIABETIC RATS
Diabetes mellitus is a metabolic syndrome involving severe insulin dysfunction in conjugation with gross abnormalities in glucose homeostasis and lipid metabolism, which has been affecting several millions of population all over the world. Despite the introduction of hypoglycemic agents from natural as well as synthetic sources, diabetes and its secondary complications continue to be a major healt...
5961
1742
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF 3-(1H-BENZO[d]IMIDAZOL-2-YLSULFANYL) METHYL-4-[PHENOXY(PHENYL) ACETAMIDO)-5-MERCAPTO-1,2,4-TRIAZOLE AND RELATED ARYLOXY COMPOUNDS
A series of new 1H-benzo[d]imidazole derivatives of 3, 4-substituted triazole. 3-(1H-Benzo[d]imidazol-2-ylsulfanyl) methyl-4-[phenyloxy(phenylacetamido)]-5-mercapto-1,2,4-triazole and related aryloxy compounds were synthesised, analysed and characterised by FTIR, 1HNMR and elemental analysis. These compounds were screened for antibacterial and antifungal activity. The antibacterial activities were...
2688
1098
WOUND HEALING AND ANTIOXIDANT POTENTIAL OF CHLOROFORM EXTRACT OF SARACA ASOCA (ROXB.)
The chloroform extracts of S. asoca bark were studied for the wound healing potential. The wound healing activity of S. asoca bark by excision, incision and dead space wound models in albino Wistar rats and antioxidant profile of this bark extract were also studied as there is an increase in the levels of free radicals during the damage of tissue. The parameters like wound contraction, period...
3586
1546
ANTIBACTERIAL EFFICACY OF CURCUMA CAESIA FROM BASTAR DISTRICT OF CHHATTISGARH, INDIA
Bio-efficacy of plants and their derivatives have been reemphasized in recent times. The present investigation was carried out to study the antibacterial efficacy of Curcuma caesia (family: Zingiberaceae) commonly known as kali haldi. The root, stem and leaf of Curcuma caesia were extracted successively with polar (aqueous, methanol), dipolar (acetone) and non-polar (chloroform) solvents, and thei...
5503
1567
POLYPHENOLIC COMPOSITION AND ANTIMICROBIAL POTENTIAL OF METHANOLIC CORIANDER (CORIANDRUM SATIVUM) SEED EXTRACT
The coriander seedextract in 80% methanol is examined for the polyphenol composition and the antimicrobial potential against pathogenic bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus pumilus. Gallic acid, caffeic acid, ellagic acid, quercetin and kaempferol are principle polyphenolics identified and quantified in the coriander extract by HPLC. The antimicrob...
11354
1712
BIOPROSPECTING POTENTIAL OF ENDOPHYTIC BACTERIA ISOLATED FROM INDIGENOUS PLANTS OF AMBALA (HARYANA, INDIA)
In the present endeavour, bioprospecting potentials (antimicrobial activity, antibiotic susceptibility pattern, enzyme activity and dye degradation ability) of endophytic bacteria isolated from different plants were explored. Total of thirty bacterial endophytes were isolated from the leaves of selected plants by using sterilization treatment followed by serial dilution agar plate technique. All t...
5215
1323
INFORMATION RESOURCES AVAILABLE AT COMMUNITY PHARMACIES IN OMAN
Background: Health care professionals, patients, public, patient caretakers, and other professionals prefer to ask their medication-related questions to community pharmacists as they are easily accessible to them. It is challenging for pharmacists to keep up the pace of medicine discovery and development and have better and effective information than the patients retrieve information independently...
6474
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CONTROLLED RELEASE IN SITU GEL OF NORFLOXACIN FOR OCULAR DRUG DELIVERY
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the cul-de-sac. Norfloxacin ophthalmic solution has been shown to be effective ocular infections and may be used in pa...
5482
1375
HYDRO-ETHANOLIC EXTRACT OF GANODERMA LUCIDUM (HEGL) SHOWS ANTI-INFLAMMATORY ACTIVITY ON THP1 CYTOKINES AND NF-B P65 RESPONSE
The present study is aimed to elucidate the antioxidant property and anti-inflammatory activity of hydro-ethanolic extract of Ganoderma lucidum (HEGL)known to possess medicinal activity against numerous diseases. The chemical composition of HEGL was quantified by colorimeteric technique in terms of total phenol and flavonoid content. Antioxidant activity was determined by 2,2’-azino-bis (3-ethyl...
6449
1571
PREVENTIVE EFFECT OF LEUCAS ASPERA METHANOLIC EXTRACT ON N-NITROSODIETHYLAMINE INDUCED SUB-ACUTE LIVER TOXICITY IN MALE WISTAR RATS
N- nitrosodiethylamine (NDEA), a chemical carcinogen widely used to initiate hepatocarcinogenesis in rats. Food stuffs such as milk and meat products, salted fish, alcoholic beverages and a few varieties of vegetables are the principal sources of nitroso compounds. NDEA has been suggested to cause oxidative stress and cellular injury due to the enhanced formation of free radicals. The present stud...
2442
853
PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT STUDIES ON ACETONE EXTRACT OF MANILKARA ZAPOTA L. SEEDS
The present study was aimed to investigate the phytochemical compounds and antioxidant activity of acetone extract of Manilkara zapota L. seeds. Preliminary phytochemical screening was carried out with the solvents of different polarities and among them acetone extract was selected for further studies. The antioxidant activity of the acetone extract was evaluated by seven different in vitro method...
3772
1354
SOLID STATE CHARACTERIZATION OF THE POLYMORPHIC CHANGES IN CANDESARTAN CILEXETIL SOLID DISPERSION WITH POLY ETHYLENE GLYCOL 8000
ABSTRACT: Aim: The main aim behind this work is to study the effect of thermal methods used for the formulation upon the candesartan cilexetil properties and to evaluate the changes due to temperature Method: Melt method was followedto study the polymorphic changes in the candesartan cilexetil solid dispersions. In this method different ratios of drug to carrier were selected for the formula...
3539
1211
DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LEVOFLOXACIN BOTH IN BULK AND PHARMACEUTICAL FORMULATION
The present study was undertaken to develop and validate a simple, accurate, precise, reproducible and cost effective UV-Visible spectrophotometric method for the estimation of levofloxacin in bulk and pharmaceutical formulation. The solvent used throughout the experiment was 0.1N NaOH. Absorption maximum (λmax) of the drug was found to be 288 nm. The quantitative determination of the drug was ca...
6163
1665
IN SILICO SCREENING OF PHYTOCHEMICALS IDENTIFIED FROM ACACIA NILOTICA BY GCMS METHOD FOR ITS ANTICANCER ACTIVITY
In present study the phytochemical analysis of the plant Acacia nilotica was done using GCMS method and seven compounds were identified as 3-picoline-2-nitro, 1-acetyl beta carboline, Hydroxy citronellal, Trans decalone, Propionic acid-2-chloro, ethyl ester, Lavandulyl acetate and D-Glucoronic acid. The anticancer activity of these seven compounds were analyzed with molecular docking study against...
5252
2022
DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHIC ENANTIOMER SEPARATION METHOD FOR THE ESTIMATION OF (S)-ENANTIOMER IN SITAGLIPTIN
A direct chiral separation method development was carried out for sitagliptin and its (S)-enantiomer on ten diverse chiral stationary phases. Chiral stationary phases, which were tested include, R, R Whelk-O1 column, macrocyclic glycopeptides namely, Chirobiotic R (Ristocetin A), Chirobiotic V (Vancomycin), Chirobiotic T (Teicoplanin), Chirobiotic TAG (Teicoplanin aglycone), OJ-H, OJ-RH belonging ...
4815
1941
PHARMACOGNOSTIC AND PHYTOCHEMICAL INVESTIGATIONS OF OPERCULINA TURPETHUM LINN. ROOT
Objective: To study detailed Pharmacognosy of the root of Operculina turpethum (Convolvulaceae) well known Ayurvedic drug (trivrit). Method: Macroscopy, microscopy, physicochemical analysis, preliminary phytochemical testing of the root and other WHO recommended methods for the standardization were done. Results: The periderm cells are tabular in shape; the phloem cells are homogeneous, tabu...
4302
1571
SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL DRUG USING 8-HYDROXYQUINOLINE
A rapid and simple spectrophotometric method is reported here for the determination of paracetamol in a commercially available tablet formulation. The method is based on the diazotization of hydrolyzed paracetamol with 8-hydroxyquinoline as a coupler to form stable azo dyes color solution. The concentration of drug paracetamol was investigated by spectrophotometrically. The azo dyes formed with 8-...
15088
2997
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR SIMULTANEOUS ESTIMATION OF CEFTRIAXONE AND TAZOBACTAM INJECTION USING RP-UPLC METHOD
This research manuscript describes simple, sensitive, accurate, precise and repeatable RP- UPLC method for the simultaneous determination of Ceftriaxone (CEF) and Tazobactam (TAZ) Injection in combine dosage form. The sample was analyzed by reverse phase C18 column (Acquity UPLC BEH 100 × 2.1 mm ID, 1.7 µm) with mobile phase. In mobile phase, Solution A containing Potassium Dihydrogen Phosphate ...
4940
1612
CONSERVATION OF MEDICINAL PLANT BRYOPHYLLUM PINNATUM (LAM.) KURZ BY IN VITRO NODAL CULTURE
Bryophyllum pinnatum is widely used in ayurvedic system of medicine as astringent, analgesic, carminative and also useful in diarrhoea and vomiting. It is naturalized throughout the hot and moist parts of India. The leaves of B. pinnatum have a variety of uses in the traditional system of medicine in India. They are eaten for diabetes, diuresis, dissolving kidney stones, respiratory tract infect...
65622
3891
COMPARISON OF BOLUS PHENYLEPHRINE, EPHEDRINE AND MEPHENTERMINE FOR MAINTENANCE OF ARTERIAL PRESSURE DURING SPINAL ANAESTHESIA IN CAESAREAN SECTION
We studied 90 patients undergoing elective as well as emergency caesarean section under spinal anaesthesia who developed hypotension after subarachnoid block (SAB). They were randomly divided in three groups: Group P Phenylephrine 100µg (n=30), Group E Ephedrine 6mg (n=30) or Group M Mephentermine 6mg (n=30) as IV bolus. Hypotension was defined as decrease in systolic arterial pressure > 20% o...
5715
1410
PRESCRIPTION PATTERN OF DRUGS USED IN THE TREATMENT OF PEPTIC ULCER DISEASE IN THE DEPARTMENT OF GASTROENTEROLOGY IN A TERTIARY CARE HOSPITAL
For more than a century Peptic Ulcer Disease (PUD) has been considered to be a major cause of morbidity and mortality. Most first line treatment for PUD involves use of acid suppressing drugs and target against the eradication of Helicobacter pylori (H. pylori) infection. However, the treatment strategy employed in India is not well studied. Hence, this study aims to provide insight into the presc...
6276
1688
IN VITRO PROPAGATION FROM INFLORESCENCE EXPLANTS OF ANISOCHILUS CARNOSUS- AN ETHNO-MEDICINAL HERB
A protocol was devised for callus induction and in vitro micro propagation of Anisochilus carnosus. Leaf, nodal and immature inflorescence explants were cultured for callusing on solid MS medium with best callusing response achieved at higher concentrations of BAP (12mg/l) alone and in combination with 2,4-D (3mg/l) and IAA (5mg/l). Bud regeneration from inflorescence callus giving maximum (9.67±...
3165
1134
DESIGN AND EVALUATION OF ORO – FLASH RELEASE FILMS OF AMLODIPINE BESYLATE
This work aimed to formulate amlodipine besylate Oro flash release films by solvent casting method. Various film forming polymers like Hydroxy propyl methyl cellulose (HPMC) E5, HPMC E15, sodium carboxymethyl cellulose, sodium alginate, xanthan gum were used and out of which HPMCE5 was found to be satisfactory. Propylene glycol was used as plasticizer at a range of 13-32%w/w of the film and 31%w/w...
3147
1837
MICROBIAL LOADS AND ASSOCIATION OF ENTEROPATHOGENIC BACTERIA IN ICE-CREAMS SOLD BY STREET VENDORS AT DHAKA CITY IN BANGLADESH
Street foods are very common sources of infectious diseases in Bangladesh. In present study the microbiological quality of three types of ice-creams obtained from street vendors in Dhaka city was evaluated. The microbiological quality of commercially produced Ice-creams (milk based, lolly and kulfi) was identified by examining total viable count (TVC) and association of enteropathogenic bacteria...
4370
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A STUDY TO EVALUATE THE PATTERN OF PRE ANAESTHETIC MEDICATION IN VARIOUS SURGICAL SPECIALTIES IN A TERTIARY CARE HOSPITAL
Objective: To analyse and compare pattern of pre anaesthetic medication use in various surgical specialties. Methodology: Data was collected retrospectively from inpatient records of major surgeries in the Department of Surgery, Orthopaedics, Neurosurgery, Paediatric Surgery, Obstetrics and Gynaecology, Plastic surgery, Urology and Vascular Surgery at M.S. Ramaiah Hospitals, during the period o...
3213
1276
HISTOPATHOLOGICAL EFFECT OF ETHANOLIC EXTRACT OF TRIDAX PROCUMBENS ON KIDNEY OF ALBINO RATS
Herbal drugs are emerging as a leading area for new drug discovery and development, and are being looked at seriously for health problem. Plants, especially used in Ayurvedic can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and or reduced toxicity. Exposure of toxicants manifests variety of pathological lesions in vari...
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1181
A COMPARATIVE STUDY OF DOXYCYCLINE AND TETRACYCLINE POLYMERIC MICROSPHERES
Solvent evaporation technique is used for the preparation of Polylactic acid microspheres loaded with two antibiotics, Doxycycline and Tetracycline, by introducing different masses for each drug. They are characterized by calculation of drug encapsulation and drug loading, measuring the particle size, examining microspheres morphology, and performing FT-IR, stability and in vitro drug release stud...
4494
1262
SCREENING OF ANTI-INFLAMMATORY AND ANTI ANALGESIC ACTIVITY OF CONVOLVULUS PLURICAULIS CHOISY
Objective: This study was designed for Screening of anti-inflammatory and anti-analgesic activity of ethanolic extract of Convolvulus pluricaulis Choisy in various animal experimental models. Material and Methods: Ethanolic extract of Convolvulus pluricaulis Choisy evaluated for anti-inflammatory activity in Carrageenan-induced paw edema, Cotton pellet-induced granuloma model. The anti-analgesi...
3431
976
DEVELOPMENT AND OPTIMIZATION OF LIPOSOMAL KETOTIFEN FUMARATE DRY POWDER USING RESPONSE SURFACE METHODOLOGY
The aim of this study was to develop and optimize nano-liposomally entrapped ketotifen fumarate (KTF) loaded dry powder inhalation (DPI) formulation using response surface methodology (RSM). Based on the 33 full factorial design (33FFD), the mass ratio of KTF solution to soybean phosphatidylcholine (SPC94), KTF/ SPC94 to 0.5 M lactose solution that after lyophilization produce lyophilized liposoma...
3293
1369
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ALOE VERA IN ACUTE VIRAL HEPATITIS
Background & objectives: Liver diseases are one of the major causes of disease burden all over world including our country so it is the need of hour to search for alternative drugs for the treatment of liver diseases. Aloe Vera is one of the most popular plants in the world, and is has been used frequently in history for its medicinal properties. Material &Methods: A total of 110 male a...
5444
1417
ETHNO MEDICAL VALUE OF HOUTTUYNIA CORDATA THUNB METHANOL EXTRACT IN EXPERIMENTALLY INDUCED DIARRHOEA
Houttuynia cordata Thunb. (H. cordata) is used as a remedy for diarrhoea and dysentery in Asia, but has not been investigated for its antidiarrhoeal properties. Antidiarrhoeal activity of 80% “methanol extract of H. cordata” (HCM) was investigated in this study using castor oil induced diarrhoea, castor oil induced intraluminal fluid accumulation as well as charcoal transit in wister albino r...
3688
1241
ANTIDIABETIC EFFECT OF CLEOME RUTIDOSPERMA DC AND SENECIO BIAFRAE (OLIV. & HIERN) EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The present study was carried out to investigate the effects of oral administration of aqueous extracts of Cleome rutidosperma leavesand Senecio biafrae roots on blood glucose, biochemical parameters, lipid profile, antioxidant enzymes activity and hepatic glucose regulating enzyme activities in Streptozotocin (STZ)-induced diabetic rats. STZ was administered as a single dose (60mg/kg wt, i.p.) to...
4712
1754
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF Cu(II), Co(III) AND Fe(III) COMPLEXES OF 2-BENZOYL-3-(NITROPHENYL)QUINOXALINE
A new series of transition metal complexes of the type ML where M = Cu(II), Co(III) and Fe(III) and L = 2-benzoyl-3-(nitrophenyl)quinoxaline have been characterized and the structural features were arrived from the elemental analysis, magnetic susceptibility, molar conductance, FT- IR, UV-Vis and NMR spectral data. From the spectral measurements and magnetic susceptibility values a square planar g...
2907
1201
DEVELOPMENT AND CHARACTERIZATION OF BILAYERD TRANSDERMAL FILM OF DICLOFENAC DIETHYLAMINE
The aim of this research work was to develop and characterise bilayer film and to investigate its potential as slow-release wound healing vehicle. The bilayer is composed of an upper layer impregnated with Diclofenac diethyl amine and a drug-free lower layer, which acted as a rate-controlling membrane. Solvent casting technique was employed to prepare transdermal films. Pre formulation studies are...
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MICROEMULSION BASED GELS FOR TARGETING NEUROPATHIC PAIN
Background: Neuropathic pain is a type of chronic pain that occurs when nerves in the central nervous system become injured or damaged. Currently only a limited number of topical treatments are available to treat it. Hence an attempt was made to alleviate symptoms of neuropathic pain by topical application of a local anaesthetic drug. Results: Microemulsions were formulated using Oleic acid as ...
6170
1615
EXPRESSION OF CHICKEN ANEMIA VIRUS VP3 GENE IN HeLa CELLs
Chicken anemia virus (CAV) encodes the protein VP3 also named “apoptin” that specifically induces apoptosis in human tumor cells. In this study, the VP3 gene cloned in p VAX1 plasmid vector was transfected in HeLa cells. The expression of CAV VP3 gene was detected using immunoperoxidase test and indirect fluorescent antibody technique. High level of gene expression was observed in HeLa cell cu...
2918
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IN VITRO ANTIOXIDANT ACTIVITY OF DIFFERENT GASTROPODS, BIVALVES AND ECHINODERM BY SOLVENT EXTRACTION METHOD
Antioxidants can protect the human body from free radicals and ROS effects. They retard the progress of many chronic diseases as well as lipid peroxidation. The commercially used synthetic antioxidants BHA and BHT have been suspected of being responsible for liver damage and carcinogenesis. Hence, a need for identifying alternative natural and safe sources of antioxidants has been created, and the...
4413
1437
EFFECT OF ANTIOXIDANTS AND HEPATOPROTECTIVE ACTIVITIES OF METHANOL EXTRACT OF BEET ROOT (BETA VULGARIS L.) AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RAT MODELS
A study on the effect of methanol extract of red beetroot (MEBV) against CCl4 induced hepatotoxicity in male albino rats of Wistar strain (150 to 180g) was done. Five groups with six rats each were used as positive control, negative control and experimental with an oral dose of CCl4 throughintra-peritoneal (IP) route and MEBV at 100µgm/ml, 200µgm/ml & 300µgm/ml per os, respectively, for 14 ...
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ISOLATION OF NATURAL BINDING AGENT FROM EULOPHIA OCHREATA LINDL. AND ITS EVALUATION
Aim and objective: To isolate the natural herbal binding agent from Eulophia ochreata Lindl. and study its evaluation properties using diclofenac as a model drug. Principle: Binders confer structural strength required by tablets during processing, handling, packaging and transportation. A number of plant mucilage, gums/hydrocolloids have been used as binding agents, suspending or emulsifying ag...
3229
1031
SYNTHESIS AND SPECTRAL STUDIES OF Mn (II) COMPLEXES WITH 2-HEPTANONE SEMICARBAZONE AND THIOSEMICARBAZONE
Complexes of Manganese(II) of general composition Mn(L)2X2 have been synthesized with ligand 2-heptanone semicarbazone and 2-heptanone thiosemicarbazone (where L = 2-heptanone semicarbazone or 2-hepatanone thiosemicarbazone and X=Cl-, SO42-, CH3COO-, NCS-, ClO4-) The IR spectral data of ligands indicate the involvement of sulphur/oxygen and nitrogen in coordination to the central metal. The ...
2836
1110
SIMULTANEOUS DETERMINATION OF METFORMIN AND PIOGLITAZONE IN PHARMACEUTICAL DOSAGE FORM BY HPLC METHOD
A rapid and accurate HPLC method was developed for determination of both metformin hydrochloride and pioglitazone hydrochloride in tablet dosage form. The chromatographic separation was conducted on Shimadzu (Prominence LC 20 UFLC XR) connected with PDA detector; using mixed column ODS/Cyano; ACE, (100 x 4.6 mm, 5 µm). The mobile phase was isocratic consisted of Acetonitrile : Phosphate buffer in...
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1194
PROTECTION FROM HEPATIC ISCHEMIA AND IMPROVEMENT OF LIVER REGENERATION BY THUJA ORIENTALIS
Liver is a vital organ performing wide range of functions; oxidative damage is implicated in the pathogenesis of various liver disorders. Present study was aimed at evaluating protective ability of Thuja orientalis Linn against thioacetamide induced hepatotoxicity in rats. Thuja orientalis has been used in Ayurvedic medicine for the treatment of various disorders. Thuja orientalis has the biologic...
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