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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 5 (2014) - Issue 6, June

Review Articles

 
Title
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1.

MALE INFERTILITY: CAUSES AND CONTRIBUTORS

Male infertility is a reproductive health disorder, emerging globally as serious medicaland social problem that results in much trauma, emotional instability and psychological stress of the affected couples. In 50% of the diagnosed cases of infertility males are reported to be the predominant causative factor. Male infertility can assess by the quality and quantity of sperm cells as well as struct...

Poonam Singh*, Rakhi Gupta , Devendra Patidar and Rama Kant Singh

Division of Toxicology, Central Drug Research Institute, B.S. 10/1 Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2095-12

2095-2112

4118

1019

2.

THIRD GENERATION MATERIALS FOR WOUND DRESSINGS

An ideal wound Dressing need to be redefined based on the nature of wound and wound classifications. Since generations, wound have been defined as self-healing process, but chronic wounds and other wound requires handling and care from different parameters like moist conditions, biocompatibility, microbial infection to mention a few. Traditional methods have been continuously worked upon to delive...

S. Sharma, A. Dua and A. Malik*

Department of Chemistry, Dyal Singh College (University Of Delhi), Lodhi Road, New Delhi-110003, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2113-24

2113-2124

7068

1382

3.

CASSIA FISTULA LINN: A REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES

Cassia fistula Linn. (Family: Caesalpinaceae), commonly known ‘Sonali’ or ‘Bandarlati’, has been used in different traditional system of medicines for various ailments since ancient times. Cassia fistula grows throughout in Bangladesh and in many other Asian countries such as India, China, Hong Kong, Philippines, Malaysia, Indonesia, and Thailand. This article aims to provide a comprehensi...

Md. Ashraf Ali

Department of Pharmacy, Southeast University, Banani, Dhaka-1213, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2125-30

2125-2130

9374

1293

4.

THERAPEUTIC POTENTIAL OF WITHANIA SOMNIFERA: A REPORT ON PHYTO-PHARMACOLOGICAL PROPERTIES

Withania somnifera belongs to the Solanaceaefamily, commonly known as Ashwagandha, Indian ginseng or Winter cherry. It is an important commercial medicinal crop, considered as similar to Panax ginseng in Chinese medicine. Different parts of this plant are used in traditional medicine for the treatment of various ailments. It provides defense against diseases, adverse environmental factors and help...

Jinu John

Inter University Instrumentation Centre, Mahatma Gandhi University, Kottayam, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2131-48

2131-2148

4496

1581

5.

GELATIN NANOPARTICLE: PREPARATION, CHARACTERIZATION AND APPLICATION IN DRUG DELIVERY

Nanotechnology plays an important role in advanced biology and medicine research particularly in the development of potential site-specific delivery systems with lower drug toxicity and greater efficiency. In terms of nanopharmaceutics, gelatin was already considered as interesting biodegradable base material in the early days of particle development. The interest was based on the facts that gelat...

Kushagri Singh* and Abha Mishra

School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2149-57

2149-2157

13082

1392

6.

2-AMINO-3-CYANOPYRIDINE: A BIOACTIVE SCAFFOLD

One of the most fascinating branches of pharmaceutical field is the chemistry of heterocyclic molecules. Heterocyclic compounds are widely distributed in nature and have biological and industrial significance. Already most of the drugs available in the market are heterocyclic in nature. Cyanopyridine, a structural motif is a cause of concern for biologist and chemist in last twenty years. Specific...

Kuntal Manna, Partha Sakha Ghosh*, Manik Das, Udayan Banik and Ashish Das

Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura (West), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2158-63

2158-2163

2951

1767

7.

NANOROBOTS: A REVIEW

Nanomedicine offers the prospect of powerful new tools for the treatment of human diseases and the improvement of human biological systems. Nanomedicine is the process of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. Nanomedicine's nanorobots are so...

Preeti Khulbe

Department of Pharmaceutical Sciences, Bhimtal campus, Kumaun University, Nainital, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2164-73

2164-2173

8361

1604

Research Articles

 
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8.

CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF ESSENTIAL OILS FROM THE LEAVES OF OCIMUM BASILICUM L. AND OCIMUM GRATISSIMUM L. (LAMIACEAE)

Ocimum basilicum L. and Ocimum gratissimum L. (Lamiaceae) are widely distributed aromatic herbs used in ethnomedicinal management of a range of inflammatory disorders. In the present work we evaluated the topical anti-inflammatory effects of the volatile constituents extracted from the fresh leaves of these plant species. Fresh leaves of the plants were subjected to hydro distillation to obtain th...

Festus B.C. Okoye*, Wilfred O. Obonga , Felix A. Onyegbule , Okechukwu O. Ndu and Chibueze P. Ihekwereme

Senior Lecturer, Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2174-80

2174-2180

4403

994

9.

THE ASSOCIATION BETWEEN SHISTOSOMIASIS AND ENTERIC FEVER IN A SINGLE SCHISTOSOMA ENDEMIC AREA IN SUDAN

Schistosomiasis is a major communicable disease with a great impact on both public health and socioeconomic status of the developing world.It is highly prevalent in tropics and causes morbidity and mortality in developing countries including Sudan. Because of its chronicity and robust immunomodulatory activity, the effects of Schistosomiasis on other diseases such as allergies, autoimmunity and in...

Mazin O. Mohager *, Samah O. Mohager and Lemya A. Kaddam

Department of Pathology, College of Medicine, Al-Jouf University, Skaka, Kingdom of Saudi Arabia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2181-84

2181-2184

2749

720

10.

TRIDAX PROCUMBENS ATTENUATES ACETAMINOPHEN – INDUCED FREE RADICAL REACTION AND CELL NECROSIS IN CULTURED MOUSE HEPATOCYTES

Drug-induced hepatotoxicity represents a major clinical problem and an impediment to new medicine development.   In vitro evaluation of hepatotoxicity is an essential stage in the research and development of new pharmaceuticals as the liver is one of the most commonly impacted organs during preclinical toxicity studies. The effect of an aqueous leaf extract of Tridax procumbens   was evaluated...

N. Gnanasekaran*, P. Murugan and Daniel Seifu

Department of Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2185-92

2185-2192

1640

573

11.

EVALUATION OF DRUG PRESCRIBING PATTERN UNDER THE NATIONAL HEALTH INSURANCE SCHEME IN RURAL GHANA

Inappropriate prescription and use of drugs is a major public health concern worldwide especially in developing countries and account for huge national health budgets. The objective of this study was to evaluate prescribing pattern of drugs under the national health insurance scheme in a rural and peri-urban setting using the World Health Organization prescribing indicators and to establish determ...

Stephen Apanga*, Dennis Chirawurah , Christopher Kudiabor , Jerome Adda , Jacob Amoako Adoesom , Damien Punguyire

Department of Community Health and Family Medicine School of Medicine and Health Sciences University for Development Studies, Tamale P.O. Box 1883 Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2193-98

2193-2198

2295

657

12.

PRELIMINARY PHYTOCHEMICAL, ANTIOXIDANT AND CYTOTOXICITY STUDY OF THE ETHANOLIC EXTRACTS OF PHYLLANTHUS ACIDUS L. ROOT BARK

Traditional medicine plays a very important role in Bangladesh, particularly at the primary health care level. The modern types of traditional medicine, namely, the Ayurvedic and Unani medicines are now officially recognized in Bangladesh .The objective of the present study was to evaluate antioxidant potential and cytotoxicity of ethanolic extract of root bark of Phyllanthus acidus L. The phytoch...

Tania Binte Wahed*, Md.Fokhrul Islam, Md. Nur Alam and Sabina Yasmin

Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2199-02

2199-2202

2213

727

13.

NIGELLA SATIVA AMELIORATES OXIDATIVE STRESS INDUCED BY DIETHYL PHTHALATE – AN IN VITRO STUDY

The present experiment was designed to assess oxidative stress, if any, caused by diethyl phthalate and its amelioration by Nigella sativa seed extract. For this, the liver and kidney homogenates were treated with different concentrations (10-40 µg/mL) of DEP with or without Nigella sativa seed extract. Lipid peroxidation, a marker for oxidative stress along with total protein content was analyze...

Heena Prajapati and Ramtej J. Verma*

Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad- 380 009, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2203-09

2203-2209

1615

638

14.

ANTIBACTERIAL ACTIVITY OF SIX MEDICINAL PLANTS USED IN TRADITIONAL MEDICINE GROWING IN BANGLADESH

The antibacterial activity of the hexane, methanol, and water extracts of Tamarindus indica, Azadirachta indica, Cucumis sativus, Eucalyptus camaldulensis, Switenia mahagoni, and Psidium guajava extensively used in traditional medicine were investigated. The disc diffusion assay method was used for the evaluation of the antibacterial activity of these extracts against 11 bacteria species. Kanamyci...

M. Mostafa*, Hemayet Hossain , M. Mahmudul Hasan , M. Anawer Hossain and Sahana Parveen

Principal Scientific Officer, Analytical Research Division, BCSIR Laboratories, BCSIR, Dhanmondi, Dhaka-1205, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2210-15

2210-2215

2650

786

15.

EVALUATION OF NOOTROPIC ACTIVITY OF HYDROXYCITRIC ACID IN PHENYTOIN TREATED RATS

The present study investigates neuroprotective effect of hydroxy citric acid (50%) on phenytoin induced cognitive impairment and oxidative stress in rats.Male Wistar rats were divided into 6 groups and each group received vehicle, phenytoin (25mg/kg, i.p) and hydroxy citric acid (400 and 800mg/kg, orally) for 14 days respectively. Memory and learning was evaluated by using the Rectangular maze, Mo...

Mada Mamatha, Thumuganti Priyanka, Swathi Konda and Meesa Madhavi*

Assistant Professor, Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal – 506001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2216-24

2216-2224

2295

797

16.

EVALUATION OF IN VITRO ANTIOXIDANT ACTIVITY OF FLOWERS OF BLEPHARIS MOLLUGINIFOLIA

The objective of this study was to characterize the non-enzymatic and enzymatic antioxidants and Scavenging activities of different extracts (Petroleum ether, Benzene, Chloroform, Acetone, Ethanol, Methanol and Water) of dried flowers powder of Blepharis molluginifolia (Acanthaceae). Enzymatic antioxidant activity such as Superoxide Dismutase, Glutathione –S-transferase, peroxidase and Catalase ...

S. Deepika* and S.V. Rajagopal

Research Scholar, Department of Biotechnology, GITAM Institute of science, GITAM University, Visakhapatnam, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2225-29

2225-2229

2105

966

17.

STABILITY-INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CEFDINIR IN PURE FORM AND PHARMACEUTICAL PREPARATION

Three Simple, rapid, sensitive, accurate and precise stability-indicating spectrophotometric methods was developed for the determination of cefdinir in bulk powder and in pharmaceutical preparation. Method (A) Ratio derivative method(1DD); is used for the determination of intact cefdinir  in presence of its degradation product at 307 nm in the range of 2 – 14 µg ml-1 with LOD of 0.049 µg ml-1...

Khalid A. Attia, Mohammed W. Nassar, Hamed M. Abou-Seada and Mohamed Saleh Emara*

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2230-37

2230-2237

1948

544

18.

ANTIPROLIFERATIVE ACTIVITY OF TRAPA ACORNIS SHELL EXTRACTS AGAINST HUMAN BREAST CANCER CELL LINES

Evaluation of the anticancer effect of Trapa acornis (Family- Trapaceae) which has long been prescribed for various infectious and malignant diseases. The shells extract of Trapa acornis has been carried out by following due procedure. Cell lines, cultures were incorporated and procured for in-vitro and in-vivo study with reference to cell proliferation assay, cell viability assay and cell cycle a...

D. Pradhan* and G. Tripathy

University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar -751004, Orissa, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2238-43

2238-2243

1660

474

19.

FORMULATION AND IN-VITRO EVALUATION OF FLOATING TABLETS OF HYDROXYPROPYL METHYLCELLULOSE K4M AND CARBOPOL-934P USING METRONIDAZOLE AS A MODEL DRUG

In the present study, metronidazole was used for preparing floating dosage forms that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. Hydroxypropyl methylcellulose (HPMC K4M) and Carbopol-934P of different ratio were used to prepare Hydrodynamically Balanced Systems (HBS) by d...

Amritha V.*, Surinder Kaur and Krishna Hari Pandey

Department of Pharmaceutics, The Oxford College of Pharmacy, Hongasandra, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2244-49

2244-2249

2295

570

20.

DEVELOPMENT AND EVALUATION OF HERBAL FORMULATION FOR THE TREATMENT OF ACNE

Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. Staphylococcus aur...

Y.M. Charde, P.H. Sharma, N.G. Choudhary and J.G. Avari*

University Department of Pharmaceutical Sciences, Department of Pharmaceutics, Rashtrasant Tukdoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur-440033, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2250-60

2250-2260

6543

2136

21.

EVALUATION OF ALPHA – AMYLASE AND ALPHA – GLUCOSIDASE INHIBITORY ACTIVITIES OF RHIZOPHORA MUCRONATA

Rhizophora mucronata Lam. belongs to mangrove plants and antidiabetic activity is one of the traditional uses of R. mucronata.  One of the anti-diabetic therapeutic strategies is inhibition of carbohydrate digesting enzymes such as alpha-amylase and alpha-glucosidase. Hence in the present study, 2 extract namely, aqueous and ethanol of Rhizophora mucronata Lam. were evaluated for their effect on ...

A.A. Rege* and A.S. Chowdhary

Department of Virology & Immunology, Haffkine Institute, Parel, Mumbai-400012, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2261-65

2261-2265

3221

1067

22.

ANTIHYPERGLYCEMIC AND ANTIOXIDANT POTENTIALS OF SESBANIA GRANDIFLORA LEAVES STUDIED IN STZ INDUCED EXPERIMENTAL DIABETIC RATS

Diabetes mellitus is a metabolic syndrome involving severe insulin dysfunction in conjugation with gross abnormalities in glucose homeostasis and lipid metabolism, which has been affecting several millions of population all over the world. Despite the introduction of hypoglycemic agents from natural as well as synthetic sources, diabetes and its secondary complications continue to be a major healt...

A. Sangeetha, G. Sriram Prasath and S. Subramanian*

Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2266-75

2266-2275

2583

800

23.

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF 3-(1H-BENZO[d]IMIDAZOL-2-YLSULFANYL) METHYL-4-[PHENOXY(PHENYL) ACETAMIDO)-5-MERCAPTO-1,2,4-TRIAZOLE AND RELATED ARYLOXY COMPOUNDS

A series of new 1H-benzo[d]imidazole derivatives of 3, 4-substituted triazole. 3-(1H-Benzo[d]imidazol-2-ylsulfanyl) methyl-4-[phenyloxy(phenylacetamido)]-5-mercapto-1,2,4-triazole and related aryloxy compounds were synthesised, analysed and characterised by FTIR, 1HNMR and elemental analysis. These compounds were screened for antibacterial and antifungal activity. The antibacterial activities were...

Debojyoti Chakraborty* and S.R. Sharma

NIT, Patna, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2276-84

2276-2284

1516

603

24.

WOUND HEALING AND ANTIOXIDANT POTENTIAL OF CHLOROFORM EXTRACT OF SARACA ASOCA (ROXB.)

The chloroform extracts of S. asoca bark were studied for the wound healing potential. The wound healing activity of S. asoca bark by excision, incision and dead space wound models in albino Wistar rats and antioxidant profile of this bark extract were also studied as there is an increase in the levels of free radicals during the damage of tissue. The parameters like wound  contraction,  period...

Deepti Bandarupalli *, Santhrani Thaakur , Srinivasa Babu Puttugunta and RLC Sasidhar

Vignan Pharmacy College, Vadlamudi, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).3385-93

2285-2293

2044

875

25.

ANTIBACTERIAL EFFICACY OF CURCUMA CAESIA FROM BASTAR DISTRICT OF CHHATTISGARH, INDIA

Bio-efficacy of plants and their derivatives have been reemphasized in recent times. The present investigation was carried out to study the antibacterial efficacy of Curcuma caesia (family: Zingiberaceae) commonly known as kali haldi. The root, stem and leaf of Curcuma caesia were extracted successively with polar (aqueous, methanol), dipolar (acetone) and non-polar (chloroform) solvents, and thei...

Dhananjay Pandey* and A.K. Gupta

Microbiology Research Laboratory, School of Studies in Life Sciences, Pt. Ravishankar Shukla University, Raipur- 492010, Chhattisgarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2294-01

2294-2301

2698

721

26.

POLYPHENOLIC COMPOSITION AND ANTIMICROBIAL POTENTIAL OF METHANOLIC CORIANDER (CORIANDRUM SATIVUM) SEED EXTRACT

The coriander seedextract in 80% methanol is examined for the polyphenol composition and the antimicrobial potential against pathogenic bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus pumilus. Gallic acid, caffeic acid, ellagic acid, quercetin and kaempferol are principle polyphenolics identified and quantified in the coriander extract by HPLC. The antimicrob...

Anita Dua*, Gaurav Garg , Dinesh Kumar and Ritu Mahajan

Associate Professor, Department of Biochemistry, University College, Kurukshetra University, Kurukshetra-136119, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2302-08

2302-2308

4299

762

27.

BIOPROSPECTING POTENTIAL OF ENDOPHYTIC BACTERIA ISOLATED FROM INDIGENOUS PLANTS OF AMBALA (HARYANA, INDIA)

In the present endeavour, bioprospecting potentials (antimicrobial activity, antibiotic susceptibility pattern, enzyme activity and dye degradation ability) of endophytic bacteria isolated from different plants were explored. Total of thirty bacterial endophytes were isolated from the leaves of selected plants by using sterilization treatment followed by serial dilution agar plate technique. All t...

Ram Kumar Pundir*, Satish Rana , Amandeep Kaur , Neha Kashyap and Praney Jain

Sr. Assistant Professor and Head, Department of Biotechnology Engineering, Ambala College of Engineering and Applied Research (ACE), Devsthali, PO- Sambhalkha-133101, Ambala, Haryana, India, Ph. 0171-2821833; Fax: 0171-2822003

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2309-19

2309-2319

2903

681

28.

INFORMATION RESOURCES AVAILABLE AT COMMUNITY PHARMACIES IN OMAN

Background: Health care professionals, patients, public, patient caretakers, and other professionals prefer to ask their medication-related questions to community pharmacists as they are easily accessible to them. It is challenging for pharmacists to keep up the pace of medicine discovery and development and have better and effective information than the patients retrieve information independently...

Saif Mohammed Al-Farsi , Hussain Abdullah Mubarak Al Rahbi and Havagiray R. Chitme*

Oman Medical College, Premedical and Pharmacy Campus Bousher, Azaiba, Muscat, P.O. Box: 620, Postal code: 130, Sultanate of Oman

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2320-29

2320-2329

3191

733

29.

CONTROLLED RELEASE IN SITU GEL OF NORFLOXACIN FOR OCULAR DRUG DELIVERY

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the cul-de-sac. Norfloxacin ophthalmic solution has been shown to be effective ocular infections and may be used in pa...

K.B. Rathod * and M.B. Patel

Research Scholar, Address: Department of Pharmaceutics, Bhagwant University, Ajmer, Rajasthan-305004, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2330-36

2330-2336

3452

766

30.

HYDRO-ETHANOLIC EXTRACT OF GANODERMA LUCIDUM (HEGL) SHOWS ANTI-INFLAMMATORY ACTIVITY ON THP1 CYTOKINES AND NF-B P65 RESPONSE

The present study is aimed to elucidate the antioxidant property and anti-inflammatory activity of hydro-ethanolic extract of Ganoderma lucidum (HEGL)known to possess medicinal activity against numerous diseases. The chemical composition of HEGL was quantified by colorimeteric technique in terms of total phenol and flavonoid content. Antioxidant activity was determined by 2,2’-azino-bis (3-ethyl...

Richa Rathor*, Rajkumar Tulsawani and Kshipra Misra

Defence Institute of Physiology and Allied Sciences (DIPAS), Lucknow Road, Timarpur, Delhi -110054, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2337-48

2337-2348

3029

951

31.

PREVENTIVE EFFECT OF LEUCAS ASPERA METHANOLIC EXTRACT ON N-NITROSODIETHYLAMINE INDUCED SUB-ACUTE LIVER TOXICITY IN MALE WISTAR RATS

N- nitrosodiethylamine (NDEA), a chemical carcinogen widely used to initiate hepatocarcinogenesis in rats. Food stuffs such as milk and meat products, salted fish, alcoholic beverages and a few varieties of vegetables are the principal sources of nitroso compounds. NDEA has been suggested to cause oxidative stress and cellular injury due to the enhanced formation of free radicals. The present stud...

B. Latha and M.S. Latha*

Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills, P.O, Kottayam- 686 560, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2349-53

2349-2353

1435

441

32.

PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT STUDIES ON ACETONE EXTRACT OF MANILKARA ZAPOTA L. SEEDS

The present study was aimed to investigate the phytochemical compounds and antioxidant activity of acetone extract of Manilkara zapota L. seeds. Preliminary phytochemical screening was carried out with the solvents of different polarities and among them acetone extract was selected for further studies. The antioxidant activity of the acetone extract was evaluated by seven different in vitro method...

C. Mohanapriya*, S. Uma , Rajathi D. Modilal , V. Nithyalakshmi

Assistant Professor, Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Madhurantakam, Kanchipuram- 603308, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2354-61

2354-2361

1965

709

33.

SOLID STATE CHARACTERIZATION OF THE POLYMORPHIC CHANGES IN CANDESARTAN CILEXETIL SOLID DISPERSION WITH POLY ETHYLENE GLYCOL 8000

ABSTRACT: Aim: The main aim behind this work is to study the effect of thermal methods used for the formulation upon the candesartan cilexetil properties and to evaluate the changes due to temperature Method: Melt method was followedto study the polymorphic changes in the candesartan cilexetil solid dispersions. In this method different ratios of drug to carrier were selected for the formula...

Ajimera Thirupathi*, Amerendar Reddy, Adi Narayana, Sarika Meshram and Sunitha Sampathi

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2362-68

2362-2368

2155

669

34.

DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LEVOFLOXACIN BOTH IN BULK AND PHARMACEUTICAL FORMULATION

The present study was undertaken to develop and validate a simple, accurate, precise, reproducible and cost effective UV-Visible spectrophotometric method for the estimation of levofloxacin in bulk and pharmaceutical formulation. The solvent used throughout the experiment was 0.1N NaOH. Absorption maximum (λmax) of the drug was found to be 288 nm. The quantitative determination of the drug was ca...

Most. Umme Bushra*, Md. Saddam Hossain , Kh. Tanvir Ahmed , Jeb-Un Nesa and Md. Firoz Mahmud

Department of Pharmacy, Manarat International University, Mirpur, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2369-73

2369-2373

3223

743

35.

IN SILICO SCREENING OF PHYTOCHEMICALS IDENTIFIED FROM ACACIA NILOTICA BY GCMS METHOD FOR ITS ANTICANCER ACTIVITY

In present study the phytochemical analysis of the plant Acacia nilotica was done using GCMS method and seven compounds were identified as 3-picoline-2-nitro, 1-acetyl beta carboline, Hydroxy citronellal, Trans decalone, Propionic acid-2-chloro, ethyl ester, Lavandulyl acetate and D-Glucoronic acid. The anticancer activity of these seven compounds were analyzed with molecular docking study against...

G. Hemamalini*, P. Jithesh and P. Nirmala

Department of Biotechnology, Nehru Arts and Science College, Thirumalayampalayam, Coimbatore – 641105, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2374-81

2374-2381

2648

1151

36.

DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHIC ENANTIOMER SEPARATION METHOD FOR THE ESTIMATION OF (S)-ENANTIOMER IN SITAGLIPTIN

A direct chiral separation method development was carried out for sitagliptin and its (S)-enantiomer on ten diverse chiral stationary phases. Chiral stationary phases, which were tested include, R, R Whelk-O1 column, macrocyclic glycopeptides namely, Chirobiotic R (Ristocetin A), Chirobiotic V (Vancomycin), Chirobiotic T (Teicoplanin), Chirobiotic TAG (Teicoplanin aglycone), OJ-H, OJ-RH belonging ...

Mahesh Kumar Mone*, Payal Jain, Santosh Kurhade, Dnyaneshwar P. Sonune and Rahul D. Kaduskar

Drug Discovery Facility, Advinus Therapeutics, Quantum Towers, Plot-9, Rajiv Gandhi Infotech Park, Phase-I, Hinjewadi, Pune 411 057, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2382-86

2382-2386

2450

1189

37.

PHARMACOGNOSTIC AND PHYTOCHEMICAL INVESTIGATIONS OF OPERCULINA TURPETHUM LINN. ROOT

Objective: To study detailed Pharmacognosy of the root of Operculina turpethum (Convolvulaceae) well known Ayurvedic drug (trivrit). Method: Macroscopy, microscopy, physicochemical analysis, preliminary phytochemical testing of the root and other WHO recommended methods for the standardization were done. Results: The periderm cells are tabular in shape; the phloem cells are homogeneous, tabu...

Pravin Sopan Borhade*, Tushar Atmaram Deshmukh , Vijay Raghunath Patil and Kishanchnad Radhesham Khandelwal

Department of Pharmacognosy, TVES’s Hon. Loksevak Madukarrao Chaudhari College of Pharmacy, Faizpur, Jalgaon - 425503 (M.S.) India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2387-92

2387-2392

2273

793

38.

SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL DRUG USING 8-HYDROXYQUINOLINE

A rapid and simple spectrophotometric method is reported here for the determination of paracetamol in a commercially available tablet formulation. The method is based on the diazotization of hydrolyzed paracetamol with 8-hydroxyquinoline as a coupler to form stable azo dyes color solution. The concentration of drug paracetamol was investigated by spectrophotometrically. The azo dyes formed with 8-...

R.B. Dixit* and J.A. Patel

Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, affiliated to Sardar Patel University, New Vallabh Vidyanagar – 388121, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2393-97

2393-2397

6357

1560

39.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR SIMULTANEOUS ESTIMATION OF CEFTRIAXONE AND TAZOBACTAM INJECTION USING RP-UPLC METHOD

This research manuscript describes simple, sensitive, accurate, precise and repeatable RP- UPLC method for the simultaneous determination of Ceftriaxone (CEF) and Tazobactam (TAZ) Injection in combine dosage form. The sample was analyzed by reverse phase C18 column (Acquity UPLC BEH 100 × 2.1 mm ID, 1.7 µm) with mobile phase. In mobile phase, Solution A containing Potassium Dihydrogen Phosphate ...

Vipul J. Panchal*, Hemant T. Desai and Ashwin G. Dave

Nirlife Healthcare (Healthcare Division of Nirma Limited), Sachana, Ahmedabad- 382 150, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2398-05

2398-2405

2726

874

40.

CONSERVATION OF MEDICINAL PLANT BRYOPHYLLUM PINNATUM (LAM.) KURZ BY IN VITRO NODAL CULTURE

Bryophyllum pinnatum is widely used in ayurvedic system of medicine as astringent, analgesic, carminative and also useful in diarrhoea and vomiting.  It is naturalized throughout the hot and moist parts of India. The leaves of B. pinnatum have a variety of uses in the traditional system of medicine in India. They are eaten for diabetes, diuresis, dissolving kidney stones, respiratory tract infect...

Chandra Gurnani*, Vikram Kumar , Shinam Mukhija , Poonam Narula and Rajat Bhola

Department of Biotechnology, Maharshi Dayanand College, Sriganganagar, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2406-11

2406-2411

14848

1321

41.

COMPARISON OF BOLUS PHENYLEPHRINE, EPHEDRINE AND MEPHENTERMINE FOR MAINTENANCE OF ARTERIAL PRESSURE DURING SPINAL ANAESTHESIA IN CAESAREAN SECTION

We studied 90 patients undergoing elective as well as emergency caesarean section under spinal anaesthesia who developed hypotension after subarachnoid block (SAB). They were randomly divided in three groups: Group P Phenylephrine 100µg (n=30), Group E Ephedrine 6mg (n=30) or Group M Mephentermine 6mg (n=30) as IV bolus. Hypotension was defined as decrease in systolic arterial pressure > 20% o...

Devender Dua, Rashida Jadliwala, Deepa Gondalia, Vandana Parmar* and Ankit Jain

Department of Anaesthesiology, P.D.U Govt. Medical College, Rajkot, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2412-17

2412-2417

2738

622

42.

PRESCRIPTION PATTERN OF DRUGS USED IN THE TREATMENT OF PEPTIC ULCER DISEASE IN THE DEPARTMENT OF GASTROENTEROLOGY IN A TERTIARY CARE HOSPITAL

For more than a century Peptic Ulcer Disease (PUD) has been considered to be a major cause of morbidity and mortality. Most first line treatment for PUD involves use of acid suppressing drugs and target against the eradication of Helicobacter pylori (H. pylori) infection. However, the treatment strategy employed in India is not well studied. Hence, this study aims to provide insight into the presc...

Veeksha Jayaram*, Cuckoo Aiyappa, Umesh Jallihal and M.C. Shivamurthy

Department of Pharmacology & Gastroenterology, M.S. Ramaiah Medical College & Teaching Hospital, Bangalore- 560054, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2418-22

2418-2422

3451

886

43.

IN VITRO PROPAGATION FROM INFLORESCENCE EXPLANTS OF ANISOCHILUS CARNOSUS- AN ETHNO-MEDICINAL HERB

A protocol was devised for callus induction and in vitro micro propagation of Anisochilus carnosus. Leaf, nodal and immature inflorescence explants were cultured for callusing on solid MS medium with best callusing response achieved at higher concentrations of BAP (12mg/l) alone and in combination with 2,4-D (3mg/l) and IAA (5mg/l). Bud regeneration from inflorescence callus giving maximum (9.67±...

Nissar Ahmad Reshi*, M.S. Sudarshana and B.P. Nandini

Plant Tissue Culture Laboratory, Department of Studies in Botany, University of Mysore, Mysore-570 006, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2423-27

2423-2427

1773

622

44.

DESIGN AND EVALUATION OF ORO – FLASH RELEASE FILMS OF AMLODIPINE BESYLATE

This work aimed to formulate amlodipine besylate Oro flash release films by solvent casting method. Various film forming polymers like Hydroxy propyl methyl cellulose (HPMC) E5, HPMC E15, sodium carboxymethyl cellulose, sodium alginate, xanthan gum were used and out of which HPMCE5 was found to be satisfactory. Propylene glycol was used as plasticizer at a range of 13-32%w/w of the film and 31%w/w...

M. Sreekanth*, Md. Gulshan, Eswar M. Gupta and N. Rama Rao

Department of Pharmaceutics including Industrial Pharmacy, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2428-35

2428-2435

1804

1071

45.

MICROBIAL LOADS AND ASSOCIATION OF ENTEROPATHOGENIC BACTERIA IN ICE-CREAMS SOLD BY STREET VENDORS AT DHAKA CITY IN BANGLADESH

Street foods are very common sources of infectious diseases in Bangladesh. In present study the microbiological quality of three types of ice-creams obtained from street vendors in Dhaka city was evaluated.  The microbiological quality of commercially produced Ice-creams (milk based, lolly and kulfi) was identified by examining total viable count (TVC) and association of enteropathogenic bacteria...

Md. Tazul Islam*, Mohammad Ruhul Amin , S.M. Rezaul Hoque and Sharmin Rumi Alim

Lecturer, Department of Food Technology and Nutrition Science, Noakhali Science and Technology University, Noakhali, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2436-40

2436-2440

2329

952

46.

A STUDY TO EVALUATE THE PATTERN OF PRE ANAESTHETIC MEDICATION IN VARIOUS SURGICAL SPECIALTIES IN A TERTIARY CARE HOSPITAL

Objective: To analyse and compare pattern of pre anaesthetic medication use in various surgical specialties. Methodology: Data was collected retrospectively from inpatient records of major surgeries in the Department of Surgery, Orthopaedics, Neurosurgery, Paediatric Surgery, Obstetrics and Gynaecology, Plastic surgery, Urology and Vascular Surgery at M.S. Ramaiah Hospitals, during the period o...

Pritam Biswas*, Niveditha and M.C Shivamurthy

Tutor and Postgraduate MD Student, 38,3rd cross, Vivekanandanagar, P.O. Maruthi Sevanagar, Bangalore – 560033, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).1000-05

2441-2446

1741

668

47.

HISTOPATHOLOGICAL EFFECT OF ETHANOLIC EXTRACT OF TRIDAX PROCUMBENS ON KIDNEY OF ALBINO RATS

Herbal drugs are emerging as a leading area for new drug discovery and development, and are being looked at seriously for health problem. Plants, especially used in Ayurvedic can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and or reduced toxicity. Exposure of toxicants manifests variety of pathological lesions in vari...

Vinita Ahirwar*, Shailendra K. Gaur and Kusum Singh

Department of Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2447-51

2447-2451

2123

650

48.

A COMPARATIVE STUDY OF DOXYCYCLINE AND TETRACYCLINE POLYMERIC MICROSPHERES

Solvent evaporation technique is used for the preparation of Polylactic acid microspheres loaded with two antibiotics, Doxycycline and Tetracycline, by introducing different masses for each drug. They are characterized by calculation of drug encapsulation and drug loading, measuring the particle size, examining microspheres morphology, and performing FT-IR, stability and in vitro drug release stud...

Rima Kassab, Paolo Yammine*, Dima Moussa and Nahed Safi

Department of Chemistry, Faculty of Sciences, University of Balamand, Tripoli, Lebanon

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2452-57

2452-2457

2502

634

49.

SCREENING OF ANTI-INFLAMMATORY AND ANTI ANALGESIC ACTIVITY OF CONVOLVULUS PLURICAULIS CHOISY

Objective: This study was designed for Screening of anti-inflammatory and anti-analgesic activity of ethanolic extract of Convolvulus pluricaulis Choisy in various animal experimental models. Material and Methods: Ethanolic extract of Convolvulus pluricaulis Choisy evaluated for anti-inflammatory activity in Carrageenan-induced paw edema, Cotton pellet-induced granuloma model. The anti-analgesi...

Parul Agarwal*, Bhawna Sharma and Shashi Alok

Institute of Pharmacy, Bundelkhand University, Jhansi - 284 128, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2458-63

2458-2463

1847

479

50.

DEVELOPMENT AND OPTIMIZATION OF LIPOSOMAL KETOTIFEN FUMARATE DRY POWDER USING RESPONSE SURFACE METHODOLOGY

The aim of this study was to develop and optimize nano-liposomally entrapped ketotifen fumarate (KTF) loaded dry powder inhalation (DPI) formulation using response surface methodology (RSM). Based on the 33 full factorial design (33FFD), the mass ratio of KTF solution to soybean phosphatidylcholine (SPC94), KTF/ SPC94 to 0.5 M lactose solution that after lyophilization produce lyophilized liposoma...

A.A. Yas

Department of Pharmaceutics, College of Pharmacy, Tikrit University, Tikrit, P.O. Box (42), Saladin, Iraq

DOI: 12 May, 2014

2264-2278

1894

797

51.

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ALOE VERA IN ACUTE VIRAL HEPATITIS

Background & objectives: Liver diseases are one of the major causes of disease burden all over world including our country so it is the need of hour to search for alternative drugs for the treatment of liver diseases. Aloe Vera is one of the most popular plants in the world, and is has been used frequently in history for its medicinal properties. Material &Methods: A total of 110 male a...

Shaily Bhatt*, Shalini Virani, Monica Sharma, Harshvardhan Kumar and K.K. Saxena

Department of Pharmacology, L.L.R.M. Medical college, Meerut, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2469-75

2479-2485

2331

727

52.

ETHNO MEDICAL VALUE OF HOUTTUYNIA CORDATA THUNB METHANOL EXTRACT IN EXPERIMENTALLY INDUCED DIARRHOEA

Houttuynia cordata Thunb. (H. cordata) is used as a remedy for diarrhoea and dysentery in Asia, but has not been investigated for its antidiarrhoeal properties. Antidiarrhoeal activity of 80% “methanol extract of H. cordata” (HCM) was investigated in this study using castor oil induced diarrhoea, castor oil induced intraluminal fluid accumulation as well as charcoal transit in wister albino r...

Sanjib Das , Sanjay Yadav*, Mukesh Dubey and Ravindra Singh

Research Scholar, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh- 786004, Assam India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2476-79

2486-2489

2010

703

53.

ANTIDIABETIC EFFECT OF CLEOME RUTIDOSPERMA DC AND SENECIO BIAFRAE (OLIV. & HIERN) EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

The present study was carried out to investigate the effects of oral administration of aqueous extracts of Cleome rutidosperma leavesand Senecio biafrae roots on blood glucose, biochemical parameters, lipid profile, antioxidant enzymes activity and hepatic glucose regulating enzyme activities in Streptozotocin (STZ)-induced diabetic rats. STZ was administered as a single dose (60mg/kg wt, i.p.) to...

I.O. Okoro*, I.A. Umar , S.E. Atawodi and K.M. Anigo

Department of Biochemistry, Ahmadu Bello University, Samaru Zaria, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2487-97

2490-2507

2297

989

54.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF Cu(II), Co(III) AND Fe(III) COMPLEXES OF 2-BENZOYL-3-(NITROPHENYL)QUINOXALINE

A new series of transition metal complexes of the type ML where M = Cu(II), Co(III) and Fe(III) and L = 2-benzoyl-3-(nitrophenyl)quinoxaline have been characterized and the structural features were arrived from the elemental analysis, magnetic susceptibility, molar conductance, FT- IR, UV-Vis and NMR spectral data. From the spectral measurements and magnetic susceptibility values a square planar g...

S. Jone Kirubavathy , R. Velmurugan , K. Parameswari and S. Chitra*

Department of Chemistry, P. S.G. R. Krishnammal College for Women, Coimbatore- 641 004, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2498-04

2508-2517

1595

681

55.

DEVELOPMENT AND CHARACTERIZATION OF BILAYERD TRANSDERMAL FILM OF DICLOFENAC DIETHYLAMINE

The aim of this research work was to develop and characterise bilayer film and to investigate its potential as slow-release wound healing vehicle. The bilayer is composed of an upper layer impregnated with Diclofenac diethyl amine and a drug-free lower layer, which acted as a rate-controlling membrane. Solvent casting technique was employed to prepare transdermal films. Pre formulation studies are...

Potlapally Laxmi*, Azeez Mohammad and G. Shirisha

Department of Pharmaceutics, Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda-508001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2508-14

2518-2524

1623

778

56.

MICROEMULSION BASED GELS FOR TARGETING NEUROPATHIC PAIN

Background: Neuropathic pain is a type of chronic pain that occurs when nerves in the central nervous system become injured or damaged. Currently only a limited number of topical treatments are available to treat it. Hence an attempt was made to alleviate symptoms of neuropathic pain by topical application of a local anaesthetic drug. Results: Microemulsions were formulated using Oleic acid as ...

Sneha Ranade*, Vaishali Londhe and Amrita Bajaj

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management SVKM’s NMIMS, Vile Parle (West), Mumbai 400056, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2515-24

2525-2534

4522

948

57.

EXPRESSION OF CHICKEN ANEMIA VIRUS VP3 GENE IN HeLa CELLs

Chicken anemia virus (CAV) encodes the protein VP3 also named “apoptin” that specifically induces apoptosis in human tumor cells. In this study, the VP3 gene cloned in p VAX1 plasmid vector was transfected in HeLa cells. The expression of CAV VP3 gene was detected using immunoperoxidase test and indirect fluorescent antibody technique. High level of gene expression was observed in HeLa cell cu...

Raushi Maurya* and Anant Rai

Mewar University, Chittorgarh, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2525-28

2535-2538

1692

598

58.

IN VITRO ANTIOXIDANT ACTIVITY OF DIFFERENT GASTROPODS, BIVALVES AND ECHINODERM BY SOLVENT EXTRACTION METHOD

Antioxidants can protect the human body from free radicals and ROS effects. They retard the progress of many chronic diseases as well as lipid peroxidation. The commercially used synthetic antioxidants BHA and BHT have been suspected of being responsible for liver damage and carcinogenesis. Hence, a need for identifying alternative natural and safe sources of antioxidants has been created, and the...

Abirami Pachaiyappan‬, ‬Arumugam Muthuvel*, ‬‬Giji Sadhasivam, Vishwa Janani Vidhya Sankar, Narmadha Sridhar and Mohan Kumar‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬

Faculty of Marine Sciences, ‬Centre of Advanced ‬Study ‬in Marine Biology, ‬Annamalai University, ‬Parangipettai-608 ‬502, ‬Tamil Nadu, ‬India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2529-35

2539-2545

2324

813

59.

EFFECT OF ANTIOXIDANTS AND HEPATOPROTECTIVE ACTIVITIES OF METHANOL EXTRACT OF BEET ROOT (BETA VULGARIS L.) AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RAT MODELS

A study on the effect of methanol extract of red beetroot (MEBV) against CCl4 induced hepatotoxicity in male albino rats of Wistar strain (150 to 180g) was done. Five groups with six rats each were used as positive control, negative control and experimental with an oral dose of CCl4 throughintra-peritoneal (IP) route and MEBV at 100µgm/ml, 200µgm/ml & 300µgm/ml per os, respectively, for 14 ...

Maximas H. Rose , P.N. Sudha* and K. Sudhakar

Associate Professor, Research Department of Chemistry, D.K.M. College for Women, Vellore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2536-45

2546-2555

3030

693

60.

ISOLATION OF NATURAL BINDING AGENT FROM EULOPHIA OCHREATA LINDL. AND ITS EVALUATION

Aim and objective: To isolate the natural herbal binding agent from Eulophia ochreata Lindl. and study its evaluation properties using diclofenac as a model drug. Principle: Binders confer structural strength required by tablets during processing, handling, packaging and transportation. A number of plant mucilage, gums/hydrocolloids have been used as binding agents, suspending or emulsifying ag...

A.A. Koparde* and C.S. Magdum

Assistant Professor, “Prabhananda”, Rukmininagar, Part-I,B-8, Karad 415110, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2546-51

2556-2561

1779

499

61.

SYNTHESIS AND SPECTRAL STUDIES OF Mn (II) COMPLEXES WITH 2-HEPTANONE SEMICARBAZONE AND THIOSEMICARBAZONE

Complexes of Manganese(II) of general composition Mn(L)2X2   have been synthesized with ligand 2-heptanone semicarbazone  and 2-heptanone thiosemicarbazone (where L = 2-heptanone semicarbazone or 2-hepatanone thiosemicarbazone and X=Cl-, SO42-, CH3COO-, NCS-, ClO4-) The IR spectral data of ligands indicate the involvement of sulphur/oxygen and nitrogen in coordination to the central metal. The ...

Pravita Kumar, Archana and Sulekh Chandra*

Department of Chemistry, Zakir Husain Delhi College, JLN Marg New Delhi-110002, ‬India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2552-58

2562-2568

1610

584

62.

SIMULTANEOUS DETERMINATION OF METFORMIN AND PIOGLITAZONE IN PHARMACEUTICAL DOSAGE FORM BY HPLC METHOD

A rapid and accurate HPLC method was developed for determination of both metformin hydrochloride and pioglitazone hydrochloride in tablet dosage form. The chromatographic separation was conducted on Shimadzu (Prominence LC 20 UFLC XR) connected with PDA detector; using mixed column ODS/Cyano; ACE, (100 x 4.6 mm, 5 µm). The mobile phase was isocratic consisted of Acetonitrile : Phosphate buffer in...

Mohamed Aly Mahmoud Aly, Mohamed Aly Abd El Aziz Aly El Degwy and Mohamed Aly Amin

Mepaco Pharmaceutical Company, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2559-63

2569-2673

2507

613

63.

PROTECTION FROM HEPATIC ISCHEMIA AND IMPROVEMENT OF LIVER REGENERATION BY THUJA ORIENTALIS

Liver is a vital organ performing wide range of functions; oxidative damage is implicated in the pathogenesis of various liver disorders. Present study was aimed at evaluating protective ability of Thuja orientalis Linn against thioacetamide induced hepatotoxicity in rats. Thuja orientalis has been used in Ayurvedic medicine for the treatment of various disorders. Thuja orientalis has the biologic...

Alok Kumar Dash

Department of Pharmacy, Suresh Gyan Vihar University, Jaipur - 302025, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2564-68

2574-2578

1683

655