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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 3 (2012) - Issue 10, October

Review Articles

 
Title
Views
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Cited
1.

PATHOPHYSIOLOGY OF NEUROPATHIC PAIN: A SYSTEMIC REVIEW

Neuropathic pain is considered as an inappropriate response caused by a lesion or dysfunction in the PNS or CNS). Neuropathic pain can manifest itself as either without a stimulus (stimulus-independent pain) and/ or as pain hypersensitivity elicited after a stimulus (stimulus-evoked pain). Stimulus-independent pain includes symptoms described by the patient such as (a) continuous, burning pain (b)...

Gurudev Singh Raina*, Rajeev Taliyan and P.L. Sharma

Neurobiology Division, Department of Pharmacology, ISF College of Pharmacy, Moga-142001, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3530-42

3530-3542

1769

531

2.

ACTINIDIA DELICIOSA: A REVIEW

Actinidia deliciosa (A. Chev.) C. F. Liang et A. R. Ferguson is a sub-family of the genus Actinidia, which is also known as Chinese gooseberry, kiwifruit, yangtao, etc. in China, and consists of 55–60 species. The genus Actinidia is a dioecious plant and is widely distributed on the Asian continent. It is also native to China and most of the species are cultured in the southwest of China. Out of...

Keyur V. Shastri*, Vidhi Bhatia, Priyank R. Parikh and Vinaya N. Chaphekar

Department of Pharmacognosy & Phytochemistry, Vivekanand Education Society’s College of Pharmacy, Chembur (East), Mumbai- 400074, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3543-49

3543-3549

3786

1587

3.

APPROACHES TO DEVELOPMENT OF SOLID – SELF MICRON EMULSIFYING DRUG DELIVERY SYSTEM: FORMULATION TECHNIQUES AND DOSAGE FORMS: A REVIEW

Solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation for therapeutic response. As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble. It is a great challenge for pharmaceutical scientist to convert those mole...

Koushik Yetukuri and Preethi Sudheer*

Department of Pharmaceutics, Krupanidhi College of Pharmacy, Sarjapura main road, Carmelaram post, Bangalore-560 035, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3550-58

3550-3558

2486

710

4.

ROLE OF ADHESIVES IN TRANSDERMAL DRUG DELIVERY: A REVIEW

Transdermal drug delivery systems (TDDS) also commonly known as “patches” are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. The therapeutic performance of a transdermal delivery system (TDS) can be affected by the quality of contact between the patch and the skin. The adhesion of the TDS to the skin is obtained by using pressure-sensitiv...

Deepthi Venna and Arshad Bashir Khan*

Department of Pharmaceutics, Krupanidhi College of Pharmacy, Sarjapura Main Road, Carmelaram post, Bangalore-560 035, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3559-64

3559-3564

4813

1279

5.

DIABETIC CARDIOMYOPATHY: INSIGHTS INTO PATHOGENESIS, DIAGNOSTIC CHALLENGES, AND THERAPEUTIC OPTIONS

Diabetic cardiomyopathy is the presence of myocardial dysfunction in the absence of coronary artery disease and hypertension. Hyperglycemia seems to be central to the pathogenesis of diabetic cardiomyopathy and to trigger a series of maladaptive stimuli that result in myocardial fibrosis and collagen deposition. These processes are thought to be responsible for altered myocardial relaxation charac...

Chintan N. Mehta

Department of Pharmaceutical Sciences, Saurashtra University Campus, University Road, Rajkot-360005, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3565-76

3565-3576

1815

581

6.

AN UPDATE OF PHARMACOLOGICAL ACTIVITY OF PSIDIUM GUAJAVA IN THE MANAGEMENT OF VARIOUS DISORDERS

In the recent years, the use of herbal products has been increasing in developing countries. Psidium guajava Linn. (Guava) family Myrtaceae is an important dietary plant used traditionally for medicinal purpose around the world. The fruit part of the guava is used because of its food and nutritional value but other part of the guava plant are used in the traditional system due to their medicinal p...

Dev Rishika* and Ramica Sharma

Rayat Institute of Pharmacy, Rail majra, S.B.S Nagar-144533, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3577-84

3577-3584

5872

2502

7.

USE OF LIPOSOMES IN CANCER THERAPY: A REVIEW

Cancer is uncontrolled growth of abnormal cells in the body. The cells causing cancer are called malignant cells. There are so many means by which one can treat the cancer such as chemotherapy, radiation treatment, surgery, etc. With all these treatments there are some side effects as loss of hairs, living cells may get killed, for surgery skilled persons are required and chances of reoccurrences ...

Harshal R. Pawar, Sagar S. Bhosale, Nikita D. Derle*

Department of Pharmaceutics, M.V.P.s’ College of Pharmacy, Nashik-422002, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3585-90

3585-3590

7579

1061

8.

VIROSOMES: A NOVEL VACCINATION TECHNOLOGY

Vaccine development has continuously shifted away from live attenuated or inactivated whole organisms. Although this approach having good efficacy but for improvement on comparison of risk/benefit ratio which needs improvement due to their highly complex compositions which result in safety concerns. As a consequence, a number of indications remained unadressed. The next generation vaccines represe...

Priyanka Rathore* and Gaurav Swami

Department of Pharmaceutical Sciences, C.T. Group of Institutes, Shahpur campus, Jalandhar, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3591-97

3591-3597

2909

660

9.

NON ALCOHOLIC FATTY LIVER DISEASE: A BRIEF OVERVIEW

The occurrence of non-alcoholic fatty liver disease (NAFLD) is around 20-30% in the general population. NAFLD is usually asymptomatic, although a minority of patients may present with evidence of progressive liver injury with complications of cirrhosis, liver failure, and hepatocellular carcinoma. In spite of being common and potentially serious, relatively little is known about the natural histor...

J.A. Ansari*, K. Shakil and A. Rashid

Department of Pharmacology, MESCO College of Pharmacy , Mustaidpura, Hyderabad-500006, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3598-02

3598-3602

1518

644

10.

RECENT APPROCHES OF “IMPURITY PROFILING” IN PHARMACEUTICAL ANALYSIS: A REVIEW

Impurity is something that is impure or makes something else impure. An impure substance may be defined as follows: a substance of interest mixed or impregnated with an extraneous or usually inferior substance, from the standpoint of its usage, the drug substance is compromised in terms of purity even if it contains another material with superior pharmacological or toxicological properties.  The ...

Shreya R. Shah*, Mayur A. Patel, Miral V. Naik, P.K. Pradhan, and U.M. Upadhyay

Department of Quality Assurance, Sigma Institute of Pharmacy, At., Post Bakrol, Ta: Waghodia, Dist: Vadodara-390019, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3603-17

3603-3617

7819

4793

11.

ANTIBODY ENGINEERING AND IMMUNOCONJUGATES FOR CANCER THERAPY

In the past three decades, monoclonal antibodies have become increasingly important class of disease modifying drugs for numerous indications including cancer, inflammatory diseases, and viral infections. Antibody therapy can be used in a variety of ways either alone or combination with cytotoxic compounds. Molecular antibody engineering technologies coupled with advances allow the generation of b...

Kolla Bramhendra Choudary

Monoclonal Antibodies Division, Research and Development Department, Inbiopro Solutions Pvt. Ltd, Bangalore-560 058, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3618-29

3618-3629

1449

854

12.

CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW. PART III; CRINUM ALKALOIDS: BELLADINE-, GALANTHAMINE-, LYCORENINE-, TAZETTINE-TYPE ALKALOIDS AND OTHER MINOR TYPES

Crinums occupy an important position within plants of family Amaryllidaceae, and many of them have been broadly used in traditional and ethnomedicines throughout the world. Due to their richness in bioactive phytoconstituents, Crinums have been subjected to extensive chemical, cytological and pharmacological investigations that focused chiefly on their alkaloidal content. Continuing our appraisal ...

John Refaat*, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3630-38

3630-3638

4138

758

13.

ANTIDIABETIC PLANTS AND THEIR ACTIVE INGREDIENTS: A REVIEW

Diabetes mellitus is a lifestyle disorder that is rapidly becoming a major threat to populations all over the globe. Over the past 30 years, the status of diabetes has changed from being considered as a mild lifestyle disorder of the elderly to one of the major causes of morbidity and mortality, affecting people of all ages.  India is slated to be the diabetic capital of the world, with 50.8 mill...

Sivani Saravanamuttu* and D. Sudarsanam

School of Genomics and Bioinformatics, Department of Advanced Zoology and Biotechnology, Loyola College, Chennai 600 034, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3639-50

3639-3650

6241

1593

14.

CAUSES AND CONDITIONS ASSOCIATED WITH REDUCED LEVEL OF VITAMIN B12: A REVIEW

Vitamin B12 plays an important role in building of genetic material, in development of normal red blood cells and in maintenance of nervous system. Major deficiency symptoms of Vitamin B12 include anemia and neurological disorders. The daily recommended intake of vitamin B12 for an adult is 1.5μg a day. Eating a diet containing required amount of vitamin B12 is the best way to treat the condition...

Chandrakant Belwal

Sterling Biotech Research Center, Vadodara, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3651-55

3651-3655

1528

507

15.

A REVIEW ON PARENTERAL CONTROLLED DRUG DELIVERY SYSTEM

The parenteral administration route is the most effective and common form of delivery for active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy a...

Milan Agrawal*, Mahesh Limbachiya , Amit Sapariya and Girish Patel

304, Mahadeep Flat, Near Shreyas crossing, Paldi, Ahmedabad-380007, , Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3656-69

3656-3669

10881

1363

Research Articles

 
Title
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17.

FORMULATION OF COATED TABLETS OF DRY HAWTHORN EXTRACT AND THE DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR EVALUATING IT’S IN VITRO DISSOLUTION

Extracts of hawthorn (Crateagus sp.) have been indicated in the treatment of cardiovascular diseases, however, tablets produced from dry extract due to a multiple of factors such as inconsistent botanical ingredients, moisture content and hygroscopicity turn to be hard with prolong disintegration. Dissolution test is increasingly being employed for the assessment of solid herbal medicinal dosage f...

M.O. Aggrey, Z. Liu *, R. Zhang , C.I. Okeke L. Ma N. Li and L. Li

Associate Professor, Tianjin State Key Laboratory of Modern Chinese Medicine, 88 Yuquan Road, Tianjin, P.R. China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3676-85

3676-3685

1466

604

18.

DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR SOME AZOLES IN PHARMACEUTICAL PREPARATION

A new, simple and rapid reversed-phase high-performance liquid chromatography (HPLC) method was developed and validated for the determination of some azoles drug (Ketoconazole, Isoconazole and Miconazole) in pharmaceutical dosage forms in Jordan market. The HPLC separation was achieved on a C18 BDS column (100 mm × 4.6 mm) using a mobile phase of acetonitrile and 0.05 M Ammonium Acetate buff...

W.A. Dayyih*, N. A. saadi, M. Hamad, E. Mallah, K. Matalka and T. Arafat

Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3686-92

3686-3692

2095

1522

19.

ARTEMISIA DRACUNCULUS, PUNICA GRANATUM AND BERBERIS VULGARIS INHIBITORY EFFECTS ON PLATELET ADHESION AND COAGULATION FACTORS IN RATS

Excessive platelet activity is one of the most important factors responsible for the incidence of cardiovascular diseases and, also, play important role in coagulation cascade. In this study, the comparative effects of methanol extracts of three herbs on adhesion of the activated platelets to fibrinogen coated plates and clotting factors were investigated. Artemisia dracunculus, Punica granatum an...

Elyas Hosseinzadeh and Razieh Yazdanparast*

Institute of Biochemistry and Biophysics, P. O. Box 13145-1384, University of Tehran, Tehran, Iran

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3693-98

3693-3698

1982

478

20.

ANALYSIS OF THE STRUCTURAL AND ULTRASTRUCTURAL ANATOMY OF SYMPHONIA GLOBULIFERA L. F. (CLUSIACEAE) LEAVES.

Symphonia globulifera L.f. (Anani) is an arboreal species, which occurs in the Amazon with antimalarial and antimicrobial properties, especially in the treatment of skin inflammations. It is also used as a general tonic and laxative for pregnant women and its sap/latex is used against rheumatism and tumors. The utilization of natural products from plant origin implies in pharmacobotanical quality ...

Eliane M. Silva Moraes , Heitor Rribeiro da Silva , Sarah Regina Pereira Camelo , Russany Silva da Costa , Janaina Gell Pontes Vieira , Flavio Vasconcelos , Roseane Maria Ribeiro-Costa , Jose Maria dos Santos Vieira , Jose Otavio Carrera Silva Junior*

Laboratory of Pharmaceutical Research and Development of the College of Pharmacy, Federal University of Pará, Rua Augusto Corrêa, n. 1, CEP: 66075-110, Guamá, Belém, Pará, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3699-03

3699-3703

1774

523

21.

IMPLEMENTATION OF A NEW COURSE FOR THE PHARMACY PROGRAM AT THE CATHOLIC UNIVERSITY OF CUYO “HERBAL MEDICINES, NUTRACEUTICALS AND DIETARY SUPPLEMENTS”

The course on "Herbal Medicines, Nutraceuticals and Dietary Supplements” has been implemented among the new courses within the 2007 curriculum of the Pharmacy Program, School of  Food, Biochemical and Pharmaceutical Sciences at the Catholic University of Cuyo, located in San Juan Province, Argentina. The main objective of the course is to provide students with the necessary tools to acquire kno...

S. Ravetti , R. M. A. Aciar , L. Y. Hergert*

School of Food, Biochemical and Pharmaceutical Sciences Catholic University of Cuyo, 1516 José Ignacio of the Rose Av. Rivadavia - (ZC 5400) San Juan, Argentina

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3704-06

3704-3706

1184

424

22.

SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MESALAMINE AND PREDNISOLONE IN COMBINED ORAL DOSAGE FORM

The objective of this study was to develop simple, precise, accurate, reproducible and economical vireodt's method for simultaneous estimation of mesalamine (MSM) and prednisolone (PRD) in combined oral dosage form. The method involved measurement of absorbance at two wavelengths, 332nm and 246nm, λmax of MSM and PRD, respectively in phosphate buffer (pH 7.4) with dimethyl formamide (DMF) as coso...

S. Jain*, N. Jain, H. Khambete and A. Rawal

Department of Pharmaceutics, Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3707-11

3707-3711

1732

456

23.

COMPARATIVE STUDY ON THE EFFECT OF DIFFERENT METHODS OF DRYING ON PHENOLICS CONTENT AND ANTIOXIDANT ACTIVITY OF SOME EDIBLE PLANTS

Antioxidants have important role in prevention and treatment of disorders and plants are considered as rich sources of radical scavenging compounds. Nowadays, many herbs are used in dried form which is possible to affect their antioxidant activity. In the present investigation, the effects of different drying methods on the antioxidant capacity and total phenolics content of some culinary plant sp...

H. Hajimehdipoor , N. Adib , M. Khanavi , M. Mobli , G.R. Amin and M. Hamzeloo Moghadam*

Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences5, No. 8 Shams Alley, Vali-e-Asr Street, 1516745811, Tehran, Iran

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3712-16

3712-3716

2931

806

24.

EFFECTS OF VANADIUM COMPOUNDS ON GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS: A META-ANALYSIS OF COMPARATIVE STUDY ON RATS

Aim: To assess the effect of vanadium compounds on glycemic control in diabetic rats. Methods: Eligible studies were identified by searching two databases; one search engine was also used for search of articles from different data bases using standardized terms and Boolean logic. Statistical analysis was performed with Meta Analyst software. Results: 56 relevant studies were found but only 8...

Asres Berhan*and Abiy Habtewolde

Hawassa University College of Medicine and Health Sciences, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3717-24

3717-3724

1857

640

25.

ANTIMICROBIAL POTENTIAL OF CRUDE EXTRACTS AND ISOLATES OF ROOTS OF MIMOSA PUDICA LINN. COLLECTED FROM THE LOCALITY OF MOHUDA ENVIRON, GANJAM, ODISHA

A complete documentation of the ethno-biological information presently existing among the diverse communities is needed at an earliest so as to restore the traditional medicinal knowledge. Research to find out scientific evidence for claims by tribal healers on Indian herbs has been intensified as being evidenced from many cited literatures. Once these local ethno medical preparations are scien...

Ijpsr

Sr. Lecturer, College of Pharmaceutical Sciences, Mohuda, Berhampur – 760002, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3725-34

3725-3734

2343

604

26.

THE RATE OF THE PREVALENCE OF HIGH-RISK PREGNANCIES AND THE RESULTS ON PREGNANT MOTHERS AND THE EFFECT ON PARAMETERS AFTER THE BIRTH

Pregnancy causes large physiologic changes in most body systems and these changes may lead to ease or harden examining some events. The purpose of this study is to define the rate of risk in pregnant women and the results in mother and fetus and also to define the risk rate of pregnancy in pregnant women and its effect on parameters after birth in patients of Educational and Medical center of Gorg...

Sam Firozi

Department of Gynecology & obstetrics, Payame Noor University, Iran

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3735-41

3735-3741

3706

1075

27.

A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND NAPROXEN IN TABLET FORMULATION

The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent fl...

Karuna B. Singh*, Shekhar B. Waikar and Suhas P. Padmane

Gurunanak College of Pharmacy, Nari, Kamptee road, Nagpur 440026, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3742-45

3742-3745

1475

526

28.

DESIGN, SYNTHESIS AND VIRTUAL SCREENING OF CERTAIN 2-PYRAZOLIN-5-ONE AND PYRAZOLIDINE-3, 5-DIONE DERIVATIVES AS POTENTIAL PPAR AGONISTS

In the quest for novel PPARg agonists as putative drugs for the treatment of type 2 diabetes, a new series of 2-pyrazolin-5-one and pyrazolidine-3, 5-dione derivatives, were designed and synthesized,  as analogues to the anti-diabetic thiazolidinedione agents (TZDs). Extensive molecular modeling studies for the designed molecules were performed; including their compare-fit studies on the generate...

Mohamed A. H. Ismaila,*, Dalal A. Abou El Ella, Khaled A. M. Abouzid, and Maiy Jaballah

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, El Khalifa ElMaamoon St., 11566, Abbasseya, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3746-57

3746-3757

2156

591

29.

FORMULATION AND IN VITRO DISSOLUTION STUDIES OF SALBUTAMOL

Salbutamol is a potent anti-asthmatic agent, is a short-acting β2-adrenergic receptor agonist act. In the present study, an attempt has been made to prepare fast dissolving tablets of Salbutamol in the oral cavity with enhanced dissolution rate and to achieve better patient compliance. The tablets were prepared with four superdisintegrants e.g., Sodium starch glycolate, Cross-povidone, Cross-carm...

G. Nageswara Rao*, M. Aparna, Uzma Javeria, S. Sharath Kumar Goud, and G. Ravi

Department of Pharmaceutical Chemistry, Telangana University, Nizamabad-503 322, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3758-61

3758-3761

1981

465

30.

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR ESTIMATION OF 6-GINGEROL IN HERBAL FORMULATIONS AND EXTRACTS

A simple, selective, precise and reliable HPTLC method of analysis has been developed and validated for estimation of 6-gingerol in extracts of dried rhizomes of Zingiber officinale and marketed formulations containing Ginger. The method employed TLC aluminium plates precoated with silica gel 60F 254 as stationary phase. The solvent system consisting of n-hexane:ether (40:60v/v). Densitometric ana...

K. Senthil Kumar, B. Manasa , Kaliloor Rahman and B. Sudhakar

Sri Adichunchanagiri College of Pharmacy, B.G. Nagara- 571 448, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3762-65

3762-3765

1821

915

31.

SIMULTANEOUS ESTIMATION OF MEFENAMIC ACID AND DICYCLOMINE HYDROCHLORIDE BY SPECTROSCOPIC METHODS

A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method was developed and validated for the determination of Mefenamic acid and Dicyclomine hydrochloride in combined dosage form. Three different analytical methods, Absorption correction method, Differential derivative method, Simultaneous equation method were developed for estimation of  Dicyclomine hydrochloride(10mg)...

Dipal Prajapati* and Hasumati Raj

Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim-Kudsad Road, Kim, Surat-394110, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3766-76

3766-3776

5465

1240

32.

COMPARATIVE ASSESSMENT OF MILK BORNE PATHOGENS AND THEIR ANTIBACTERIAL SENSITIVITY

Milk is considered as a highly nutritious and valuable human food, consumed by the people in a variety of different products. The present work is an effort to have a survey of number of bacteria present in different milk samples viz., Raw, Boiled, Pasteurized and Skimmed milk collected from local market of Haridwar and its adjoining areas by serial dilution method and the quality of milk assessed ...

Padma Singh and Priyanka Chaudhary*

Department of Microbiology, Kanya Gurukul Campus, Gurukul Kangri University, Haridwar-249407, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3778-82

3778-3782

2096

780

33.

POTENTIAL LARVICIDES IN NIGERIAN HERBAL RECIPES

Investigations into the larvicidal potential of crude extracts of ten Nigerian plants were carried out against the fourth instar larvae of Anopheles gambiae mosquito. The phytochemical screening revealed that both anthraquinones and cyanogenic glycosides were absent in all the plants. However, alkaloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids were either present or absent. ...

Olawale H. Oladimeji*, Leonard Ani and Emmanuel Nyong

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3783-87

3783-3787

1517

1032

34.

DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF CARVEDILOL USING SUBLIMATION TECHNIQUE

The purpose of the study was to design and evaluate fast dissolving carvedilol tablets using β-Cyclodextrin and superdisintegrants adopting sublimation technique. Tablets were prepared by direct compression method. Tablets were evaluated for their physico chemical properties, wetting time, disintegration, in-vitro release and stability studies. SEM analysis was carried out to determine the surfac...

Mohd Azharuddin*, Krishnananda Kamath and A.R. Shabaraya

Department of Pharmaceutics, Srinivas College of Pharmacy, Valachil, Mangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3788-95

3788-3795

1839

497

35.

VALIDATED HPTLC METHOD FOR ESTIMATION OF CURCUMIN CONTENT IN DIETARY SUPPLEMENT FORMULATION

The simple, accurate and precise HPTLC method was developed for quantification of curcumin content in dietary supplement formulation. In this method, individual curcuminoids (curcumin, demethoxy curcumin and bisdemethoxy curcumin) with piperine were resolved using mobile phase n-hexane: ethyl acetate: methanol: formic acid (8: 2: 1: 2-3 drops v/v) on a plate precoated with silica gel 60 F254 and q...

V.A. Kekre* and S.G. Walode

Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Off Mumbai - Pune Express way Kusgaon (B.K), Lonavala-410401, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3796-00

3796-3800

2600

752

36.

A COMPARATIVE ANALYSIS OF THE PHYTOCHEMICAL VARIABILITY OF ARBOREAL RUTACEAE MEMBERS

The accumulation tendencies of different classes of compounds within the related Rutaceae genera and species are well documented, considering different populations and plant individuals. Aegle marmelos is one species which has been largely exploited in India in indigenous systems of medicine as a potential herbal medicine for abdominal disorders. The species has been listed as Vulnerable due to it...

Rekha R. Warrier*, P. Priyadharshini and A.N. Arun Kumar

Institute of Forest Genetics and Tree Breeding , P.B. No.1061, R.S.Puram, Coimbatore-641002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3801-05

3801-3805

1702

755

37.

ASSESSMENT OF PRESCRIBERS ADHERENCE TO THE BASIC STANDARDS OF PRESCRIPTION ORDER WRITING IN SERBO AND ASSENDABO HEALTH CENTERS, JIMMA ZONE, SOUTH WEST ETHIOPIA

Background: Since prescribing is the first and foremost component in the process of using drugs, it is a vital element in rational drug use. The concept of rational prescribing requires that the prescriber follows correct and complete prescription writing. Objective: To assess prescribers adherence to the basic standards of prescription order writing in Serbo and Assendao health centers. Met...

Amare Sisay and Hailemeskel Mekonnen

Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3806-13

3806-3813

1839

536

38.

ANTIMICROBIAL ACTIVITY OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF CASSIA ANGUSTIFOLIA VAHL- IN VITRO STUDY

The aim of the study was to evaluate and compare the antimicrobial activity of crude leaf extracts of Cassia angustifolia Vahl. The leaves of Cassia angustifolia Vahl. were taken from three different regions of India such as SR-1 from South India, SR-2 from Rajasthan and SR-3 from Haryana. Antimicrobial suspectibility testing of ethanolic and aqueous leaf extracts of Cassia angustifolia Vahl. were...

Parul Sood*, Surender Kumar Sharma and Mamta Sood

Assistant Professor, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Baddi, Solan-143001, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3814-16

3814-3816

1854

545

39.

FORMULATION STRATEGY FOR DISSOLUTION ENHANCEMENT OF SIMVASTATIN

The present work aim was “Formulation Strategy for Dissolution Enhancement of Simvastatin”. Simvastatin is lipid lowering drug which is known as HMG CoA reductase. The objective of this study was to increase the solubility of poorly water soluble drug, namely simvastatin, by the formation of solid dispersion and complex and also using the microwave induction technique on these formations. For ...

Neha Parmar*, Arti Bagda , Meghal Patel and Sandip Patel

Shree H.N. Shukla Institute of Pharmaceutical Education and Research, Rajkot, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3817-22

3817-3822

2516

958

40.

INVESTIGATIONS OF PHYSICO-CHEMICAL STATUS OF GROUND WATER OF SINGRAULI DISTRICT, MADHYA PRADESH, INDIA

Ground water is the most preferred water source in current scenario. Once believed to be safe from pollution as it is available many band below the surface, is now provided to be prone to pollution by research investigators. Various causes associated for the contamination of ground water. The major cause of the contamination of ground water may be due to improper disposal of industrial waste. The ...

Rajesh Pandey* and Sunil K. Pandey

Department of Biochemistry, Awadesh Pratap Singh University Rewa- 486003, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3823-28

3823-3828

2034

502

41.

EFFECT OF CEREBELLAR FASTIGIAL NUCLEUS LESION ON IMMUNITY IN WISTAR ALBINO RATS

The aim of the present study was to investigate the role of cerebellum in immunomodulation as cerebellum was thought traditionally to play an important role in voluntary motor activities. Rats weighing about 200-220 gm were subjected to bilateral electrolytic lesion of fastigial nucleus and following immune parameters were assessed- leucocyte migration inhibition test, foot pad thickness, antibody...

G. Gajalakshmi*, S. Dharini , G. Sathya Narayanan and R. Sheela Devi

Department of Physiology, Meenakshi Medical College and Research Institute, Enathur, Kancheepuram, Tamil nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3829-36

3829-3836

1666

512

42.

NEUROPROTECTIVE EFFECT OF CURCUMIN WITH A FIXATOR OF ABSORPTION AGAINST BOTH ALUMINIUM NEUROTOXICITY AND ALZHEIMER’S DISEASE (EXPERIMENTAL STUDIES IN MICE)

The versatility of Aluminium chemistry will ensure its burgeoning use in the future in all manner of applications. This very same chemistry will also ensure its increased biological availability in all biota including Man. We do not know enough about the biological chemistry of a chronic and sub-acute exposure to Aluminium to be able to predict its impact on human health. Although the hypothesis o...

Salima Douichene, Noureddine Djebli and Khayra Zerrouki

Department of biology, Faculty of SE&SNV Mostaganem University, Mostaganem, Algeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3837-41

3837-3841

1563

521

43.

POLYSACCHARIDE MATRIX TABLET FOR COLON SPECIFIC DRUG DELIVERY

The objective of the present study was to prepare a matrix tablet for colon targeting. Natural gaums (guar gum and xanthan gum) were used for the preparation of colon targeted drug delivery system. Different concentrations of guar gum and xanthan gum and their combinations were tried for the purpose. The prepared tablets were evaluated for in-process parameters as well as colon targeting character...

Amit Kumar Panigrahi*, Mathrusri M. Annapurna and K. Himasankar

FARGEM Pharmaceutical Research and Development Center, Düzce, Turkey

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3842-46

3842-3846

1453

550

44.

ANTIDIARRHOEAL ACTIVITY OF LEAVES OF ACORUS CALAMUS

In developing countries, the majority of people living in rural areas almost exclusively use traditional medicines to treat all sorts of diseases including diarrhea. Many plants namely Andrographis paniculata, Acacia catechu, Acacia chandra, Terminalia chebula, Pterocarpus marsapium, Cassia auriculata etc. available in india are used in traditional folklore medicine for the treatment of diarrhea. ...

M.D. Kapadia* and A.R. Kharat

Rofel, Shri G.M.Bilakhia College of Pharmacy, Vapi-396191, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3847-50

3847-3850

2201

802

45.

BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND ZN(II) COMPLEXES WITH SCHIFF BASE 4, 4-(1, 4-PHENYLENE BIS(AZAN-1-YL-1- YLIDENE)) BIS(METHAN-1-YL-1-1-YLIDENE)-1, 2-DIOL. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION

Condensation reaction of 1, 4-phenylene diamine and Protochatechu aldehyde in 1:2 molar ratio resulted in the formation of new Schiff base ligand 4, 4-(1,4-phenylene bis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-1-ylidene)-1, 2-diol; (H4L) .From the direct reaction of the ligand (1) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II)nitrates in 2M:1L molar ratio, the five new neutral comp...

Amr Nassar*, Ali Hassan, Yahiya Ahmed and Ahmed Elkmash

Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3851-60

3851-3860

1326

431

46.

ANTI-DIABETIC ACTIVITY OF METHANOLIC AND ETHYL ACETATE EXTRACTS OF WRIGHTIA TINCTORIA R.BR. FRUIT

The present work was undertaken to investigate various extracts of fruit of Wrightia tinctoria (F-Apocyanacea) for anti-diabetic activity in alloxan induced diabetic rats. A comparison was made between the action of extracts and known anti-diabetic drug glibenclamide (10mg/kg body weight). Oral administration of methanolic extract at a dose of 300 mg/kg/b. wt and ethyl acetate extract at a dose of...

M. Sandhya Rani* , Rao S. Pippalla , G. Krishna Mohan and M. Gangaraju

Centre for Pharmaceutical Sciences, Institute of Science and Technology, JNTU, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3861-66

3861-3866

1958

799

47.

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF ROSUVASTATIN CALCIUM AND ASPIRIN IN CAPSULE DOSAGE FORM

This paper described validated high performance thin layer liquid chromatographic (HPTLC) method for estimation of Rosuvastatin Calcium (ROSU) and Aspirin (ASP) in capsule dosage form. The method involved separation of components by TLC on a precoated silica gel 60 F254 using a mixture of n-Hexane: Acetone: Ethyl acetate: Formic acid (6:3:1:0.2 v/v) as a mobile phase. Detection of spots was carrie...

Pallavi H. Tank*, K. R. Vadalia, Z. R. Dedania

Shree H. N. Shukla Institute of Pharmaceutical Education & Research, B/H-Marketing Yard, Nr. Lalpari Lake, Amargadh (Bhichari), Rajkot- 3600, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3867-70

3867-3870

1992

1103

48.

QUANTITATIVE ANALYSIS OF PARACETAMOL AND DICLOFENAC IN COMBINED DOSAGE FORM BY FIRST DERIVATIVE AND SIMULTANEOUS EQUATION METHOD IN APPLICATION TO THE DETERMINATION OF DISSOLUTION STUDY

Two simple, economical, precise, and accurate methods are described for the simultaneous determination of Paracetamol and Diclofenac in combined tablet dosage form. The first method is first- order derivative zero crossing method. The first order derivative absorption at 275.6 nm (zero cross point of Diclofenac) was used for Paracetamol and   242.69 nm (zero cross point of Paracetamol) for Diclo...

D. Phaneemdra* and G. Nagamalleswari

Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3871-76

3871-3876

6519

1755

49.

FORMULATION OF OIL CONTAINING PLUCHEA LANCEOLATA EXTRACT OBTAINED THROUGH DIFFERENT ORGANIC SOLVENTS AND EVALUATION OF ITS ANTI-INFLAMMATORY ACTIVITY BY TOPICAL APPLICATION

Pluchea lanceolata has been used in massage oil as well as in traditional ayurveda as a potent pain reliever. The traditional Method of obtaining oil is simply based on taking water as the medium for extraction. The water extract obtained is then boiled with oil, till the water is completely evaporated. Here, our aim is to replace water by different organic solvents and obtain oil which has much b...

Killol S. Chokshi*, Divyesh B. Ladola, Aditya J. Purohit, Jaimin S. Suthar, Pratha K. Patel, Anupsinh J. Solanki and Rajiv Kukkar

Indukaka Ipcowala College of Pharmacy, New V.V. Nagar, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3877-80

3877-3880

1753

675

50.

BARRIERS TO IMPLEMENTATION OF PERFORMANCE-BASED MANAGEMENT PRACTICES IN PHARMACIES IN A DEVELOPING COUNTRY

The objective of this study was to conduct a survey and determine the barriers to implement performance-based management in pharmacies in Trinidad. PBM is defined as “a systematic approach to performance improvement through an on-going process of establishing strategic performance objectives, measuring performance, collecting, analyzing, reviewing, and reporting performance data, and using that ...

Sandeep Maharaj, Sureshwar Pandey , Farana Mohammed , Saeeda Ali , Amelia Niamath , Chandika Persad , Brent Roopchandsingh , Fazal Ali , Isaac Dialsingh , Robin Antoine and Ashok Sahai

Pharmacy School, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3881-86

3881-3886

1858

639

51.

EFFECT OF NATURAL AND ARTIFICIAL SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING DICLOFENAC TABLET

FDTs are designed to disintegrate rapidly on contact with saliva and enables oral administration without water or chewing, these formulations offer increased convenience and ease of administration with the potential to improve patient compliance, particularly in certain populations, where swallowing of conventional solid oral dosage forms presents difficulties. In the present study, the effect of ...

Chanda Ray* and Vandana Arora

Lloyd Institute of Management & Technology, Mahamaya Technical University, Greater Noida, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3887-92

3887-3892

1741

530

52.

IDENTIFICATION OF SPECIFIC MUTATIONS IN HUMAN RAS GENE

Cancer is a group of disease characterized by unregulated cell growth and spread of cells from site of origin to other sites in body. Two main genetic changes lead to cancer they are inactivation of tumour suppressor gene and activation of proto-oncogene. Ras gene is a proto-oncogene, when this gene activated it stimulates signalling pathway and that causes unregulated proliferation of cells. Ras ...

Mohammed Qumani Ahmed*, Syed Nazar Hussain , Awdah Masoud Al-hazimi , Mohammad Feroze Fazaludeen, Abdelbaset Mohamed Elasbali and Ibrahim Ginawi

MS Pharmacology, Department of Pharmacology, College of Medicine, University of Hail, Hail, KSA

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3893-14

3893-3914

2495

534

53.

DESIGN AND OPTIMIZATION OF CONTROLLED RELEASE OCULAR INSERTS OF DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE FOR TREATMENT OF GLAUCOMA

Goal of the present investigation was to formulate ocular inserts of dorzolamide hydrochloride and timolol maleate for the treatment of glaucoma. Ocular inserts of dorzolamide hydrochloride and timolol maleate were prepared using different polymers ethylcellulose, Eudragit RL 100, and Eudragit RS100 by solvent casting method with an objective to increasing the contact time, achieving controlled re...

K.M. Manjunatha*, G.T. Kulkarni and Md. Ismail

Assistant Professor, Department of Pharmaceutics, Bapuji Pharmacy College, S.S. Layout, Davangere-577 004, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3915-22

3915-3922

2185

570

54.

THE EFFECT OF ELICITORS ON THE PRODUCTION OF VASICINE FROM JUSTICIA ADHATODA L. CELL SUSPENSION CULTURES

In this study, α-naphthyl acetic acid and mannitol were used as elicitors to improve the productivity of useful metabolite, vasicine for archiving high concentration in Justicia adhatoda L. cell suspension cultures. When the cells were treated with 3mg 100 ml-1 suspension of α-naphthyl acetic acid,   the vasicine concentration was increased by 1.65 mg ml-1 in 15 days culture compared to untrea...

Rashmi Pa and Linu Mathew*

School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, 686 560, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3923-26

3923-3926

1814

715

55.

PERMEATION STUDIES OF PIOGLITAZONE HCL FROM FICUS CARICA FRUIT MUCILAGE MATRIX TRANSDERMAL PATCHES

The main purpose of the present study was to develop matrix moderated transdermal patches of Pioglitazone HCl using various ratios of Ficus carica fruit mucilage. Physical parameters such as moisture content, moisture uptake, tensile strength, elongation and folding endurance were evaluated. The matrix type transdermal patches were prepared using Pioglitazone HCl with Ficus carica fruit mucilage b...

N.T. Rangari*, T.M. Kalyankar, P.K. Puranik and S.R. Chaudhari

Amrutvahini College of Pharmacy, Tal: Sangamner, Dis: Ahmadnagar-4262608, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3927-31

3927-3931

1910

552

56.

CHEMICAL EXAMINATION OF A NEW ALLELOCHEMICAL FROM STEMS OF GLOSSOCARDIA BOSVALLIA DC.

Glossocardia bosvallia DC.1-3 belongs to family Composite which is commonly known as “Patthar-suva or seri” in Hindi. It is found almost throughout in India and Deccan Peninsula. It is a small annual herb, 10-20 cm tall. The tribal inhabitants of western Maharashtra use a decoction of the plant as febrifuge. It has a bitter taste and fennel like odor. Besides serving as a medicinal plant Pi...

R. N. Yadava and Shirin Khan*

Natural Products Laboratory, Department of Chemistry, Dr. Hari Singh Gour Central University, Sagar- 470 003, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3932-35

3932-3935

1265

516

57.

UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TELMISARTAN IN BULK AND TABLET DOSAGE FORM

A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The spectra of Telmisartan in 0.1 N NaOH and distilled water (20:80) shows λmax at 234 nm and estimation was carried out by A (1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2= 0.999) over the concentrat...

Sonali D. Rathod*, P.M. Patil, Santosh S.A. Waghmare and P.D. Chaudhari

Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Nigdi Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3936-39

3936-3939

3432

698

58.

FORMULATION, TASTE MASKING AND EVALUATION OF ALMOTRIPTAN ORAL DISINTEGRATING TABLETS

The aim of the present study is to formulate and evaluate taste masked Almotriptan orally disintegrating tablet by using different taste masking agents and different superdisintegrants in different ratios, Almotriptan is a triptan class anti-migraine drug with rapid action, highest bioavailability and low side effects compared to other triptan class of drugs used in the treatment of migraine, Thus...

Akhila Alladi* and N. Damodharan

Department of Pharmaceutics, SRM College of Pharmacy, Chennai- 603 203, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3940-46

3940-3946

2138

829

59.

COMPARISON OF VARIOUS NATURAL SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING CARVEDILOL TABLET

In the present investigation, fast dissolving tablets of Carvedilol were formulated by using various natural superdisintegrant like Plantago ovata, Lepidium sativum, Fenugreek and Guar gum. A Direct compression method was used to prepare fast dissolving tablets containing Carvedilol as a model drug using natural superdisintegrants. Prepared formulations were evaluated for Precompression parameters...

Vikas Sharma* and Vandana Arora

Lloyd Institute of Management & Technology, Mahamaya Technical University, Greater Noida, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3947-54

3947-3954

2580

759

60.

ANTI-INFLAMMATORY ACTIVITY OF WHOLE PLANT OF POLYGALA ROSMARINIFOLIA WIGHT & ARN (POLYGALACEAE)

In the present study, Polygala rosmarinifolia whole plant was extracted with ethanol and evaluated for anti-inflammatory activity in rats using a carrageenan induced paw edema method. Ethanol extract exhibits potent anti-inflammatory activity at 200mg/kg at 3rd hr after administration is compared with reference standard drug, Indomethacin. Observed pharmacological activity in the present study pro...

M. Alagammal , A. Nishanthini and V.R. Mohan

Ethnopharmacology Unit, Research Department of Botany, V. O. Chidambaram College, Tuticorin, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3955-57

3955-3957

1235

430

61.

STUDY OF ANTIBIOTIC SUSCEPTIBILITY TEST OF MODERN GENERATION OF DRUGS AGAINST UPPER RESPIRATORY TRACT PATHOGENS

Nasal infection or sinusitis is an inflammation of nasal passages caused by both viral and bacteriological pathogens. Antimicrobial resistance has universally recognized as growing problem concern about suitable therapy for nasal infection. The study was aimed at determining the prevalence and antimicrobial susceptibility against nasal infecting microorganisms. 50 clinical samples were taken from ...

Swati Bagde, Shruti Parashar, Rakesh Kumar Patidar and Vinod Singh*

Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3958-65

3958-3965

1709

515

62.

VARIANTS OF ORAL GLUCOSE TOLERANCE TEST (OGTT) CURVE IN GESTATIONAL DIABETES MELLITUS (GDM)

Objective: Gestational diabetes mellitus is defined as “carbohydrate intolerance resulting in hyperglycemia of variable severity with onset or first recognition during pregnancy, whether or not insulin is used and regardless of whether diabetes persists after pregnancy. There is evidence that asymptomatic hyperglycemia during pregnancy leads to important morbidity in the mother and foetus. Hence...

S. Gowda*, P.B. Desai , V.S. Kagwad , S.J. Shetty and M.B. Ilakal

Professor, Department of Biochemistry, Subbaiah institute of medical sciences and Hospital, Shimoga, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3966-70

3966-3970

3165

565

63.

THE ROLE OF INTRAVENOUS AMINO ACID INFUSION IN OLIGOHYDRAMNIOS

Oligohydramnios means the fetus is in a compromised condition. Ante partum amniotic fluid index (A.F.I.) assessment is one of the reliable, good predictor and standard technique for assessment of fetal well-being in antenatal period. In the present study 25 cases of Oligohydramnios in the third trimester were given intravenous amino acid in 1000cc of 10% fructodex drip on 1st day and the amino aci...

Ritu Gupta , Sanjay Kumar Porwal* Madhusudan Swarnkar and Sanjeev Gupta

B-4, Anand Vihar, Civil Lines, Jhalawar, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3971-74

3971-3974

25989

1769

64.

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY USING HIBISCUS ROSA – SINENSIS MUCILAGE AND MODIFIED GUM KARAYA

In the present study, natural gums (Hibiscus rosa – sinensis mucilage and Modified gum karaya) was investigated as superdisintegrants for use in fast dissolving tablet formulations containing amlodipine besylate. Fast dissolving tablets of amlodipine besylate was formulated using different concentrations (2, 4, 6, 8, 10) of natural superdisintegrant viz; Hibiscus Rosa – sinensis mucilage and m...

Sudheshnababu Sukhavasi* and V. Sai Kishore

Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3975-82

3975-3982

2902

675

65.

DRUG USE EVALUATION OF BRONCHODIALATORS IN PAEDIATRICS IN A TERTIARY CARE HOSPITAL

The use of bronchodilators has been increasing for the past few decades. The literatures have reported a high rate of adverse events. It has also been found out that beta-agonists are associated with an increased morbidity and mortality rate. Respiratory tolerance develops due to regular use of beta-agonists, which are widely prescribed in asthma and bronchiolitis also is of major concern. Obje...

K.M. Binu, Nimmy N. John, Alan Lee Mathew, H. Doddayya and Ashok Kumar Malpani

Department of Pharmacy Practice, N.E.T. Pharmacy College, Raichur, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3983-87

3983-3987

2185

724

66.

PHYTOCHEMICAL CHARACTERISATION AND PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACT OF AVICENNIA ALBA

The history of herbal medicines is as old as civilization. For this purpose of ascertaining the phytochemical constituents, the present work was performed into the phytochemical investigation of the plant Avicenna alba. Separation and isolation of the constituents of interest, characterization of isolated compounds and investigation of the biosynthetic pathways of the particular pathway and quanti...

Sandip Kr. Baidya*, Anirban Deb and Raja Chakraverty

Department of Pharmacology, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol-713301, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3988-92

3988-3992

2043

512

67.

VARIED ANTI- INFLAMMATORY ACTIVITY OF INDOMETHACIN IN DIFFERENT EXPERIMENTAL ANIMAL MODELS

OBJECTIVE: To evaluate the anti-inflammatory activity of indomethacin in different experimental anti-inflammatory animal models METHODS: Swiss albino rats weighing around 150 g – 250 g of either sex were randomly selected and divided into 6 groups (n=6) for 3 models, each having control and  Standard . Materials used are Carrageenan, turpentine, Cotton pellets, Mercury and water plethysmo...

R.N. Suresha, Sushma V. Naidu, J. Huralikuppi and V. Ashwini

Department of Pharmacology, JSS Medical College, (A Constituent College of JSS University, Mysore), SS Nagar, Mysore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3993-98

3993-3998

2493

719

68.

DEVELOPMENT AND VALIDATION OF RATIO DERIVATIVE SPECTROPHOTOMETRIC FOR SIMULTANEOUS ESTIMATION OF METOLAZONE AND SPIRONOLACTONE IN PHARMACEUTICAL DOSAGE FORM

In the present work for the simultaneous estimation of Metolazone (METO) and Spironolactone (SPI) Ratio Derivative Spectrophotometric method have been developed. In this method the overlapping spectra of Metolazone and Spironolactone were well resolved by making use of the first-derivative of the ratios of their direct absorption spectra. Methanol:water (1:4) was used as solvent for the method. Am...

Arati Chaudhary*, K.R. Vadalia and Punam Thummer

Department of Quality Assurance, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Rajkot-360002, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3999-03

3999-4003

1443

478

69.

FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE PULSATILE DRUG DELIVERY SYSTEM FOR CHRONO BIOLOGICAL DISORDER: ANTI HYPERTENSION

The objective of the present study was to develop and evaluate an oral pulsatile drug delivery system to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined log time of 5 hrs (+ 0.25 hrs). The basic design of the pulse in cap formulation of metoprolol provides time controlled release to treat the nocturnal symptoms of hypertension and angina pectoris. The ...

A. Anil Kumar and K. Rajyalakshmi

Vikas college of Pharmacy, Putrela Road, Vissannapeta, Krishna dt- 521215, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).4004-09

4004-4009

1809

765

70.

STUDY OF ANTIATHEROSCLEROTIC ACTIVITY OF POLYHERBAL PREPARATION USING RAT AS AN EXPERIMENTAL ANIMAL MODEL

Atherosclerosis is one of the risk factors for coronary artery disease. The present study highlights the antiatherosclerotic activity of Methanolic extract of polyherbal preparation in experimentally induced atherosclerotic rats. Atherosclerosis was developed in male Albino Wistar rats, which were randomly divided into five groups of six animals each; by feeding with high cholesterol diet for 21 d...

J.P. Machhi* and N.N. Shah

Department of Pharmacology, A.R. College of Pharmacy & G.H. Patel Institute of Pharmacy, Vallabh Vidyanagar- 388 120, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).4010-18

4010-4018

2026

719

71.

HERBAL PRODUCT REALIZATION IN ACCORDANCE WITH WHO AND ISO GUIDELINES

Background: Following the Alma-Ata Declaration of 1978, the World Health Organization (WHO) began the issuance of guidelines for developing standardized herbal preparations from Traditional Medicine (TM). Similarly in 1987, the International Organization for Standardization (ISO) launched the most anticipated industrial standard (ISO 9001) in world history. The seventh (7th) clause of ISO 9001’s...

S. J. Ameh*, F. Tarfa, S. Ayuba, K. S. Gamaniel

Department of Medicinal Chemistry and Quality Control (MCQC) 1, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, PMB 21 (Garki), Abuja, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).4019-35

4019-4035

2180

477

72.

FORMULATION AND EVALUATION OF STAVUDINE ORAL DISINTEGRATION TABLETS

Stavudine an anti-retroviral drug is used for treating HIV now-a-days. The present approach aims to formulate an orally disintegrating tablet of stavudine for better patient compliance and bypassing the hepatic metabolism. In order to have an orally disintegrating tablet of stavudine, there is a need to mask the bitter taste. For the masking of bitter taste mannitol is used as taste masking agent....

K. Lavanya Latha Reddy , T. Sowjanya, V. Sankar , G. Naga Sowjanya , R.B. Desireddy

Nalanda Institute of Pharmaceutical Sciences 1, Siddharth Nagar, Kantepudi, Sattenpalli, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).4036-39

4036-4039

1702

575

73.

IDENTIFICATION AND ANTIMICROBIAL ACTIVITY OF SAPONIN FRACTION FROM THE LEAVES OF BARLERIA CRISTATA L.

A simple HPTLC method was used to determine the saponin profile of Barleria cristata L. crude leaf extract. The antimicrobial activity of saponin fraction from the leaves of Barleria cristata L. was studied in-vitro against four bacterial species and four fungal species by agar disc diffusion method. Klebsiella Pneumonia, Staphylococcus aureus, E. coli, Aspergillus parasites were the most inhibite...

K. Amutha and D. Victor Arokia Doss*

Biochemistry Department, PSG College of Arts and Science, Civil Aerodrome Post, Coimbatore-641 014, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).4040-44

4040-4044

2189

850

74.

A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND NAPROXEN IN TABLET FORMULATION

The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 μm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent fl...

Karuna B. Singh*, Shekhar B. Waikar and Suhas P. Padmane

Gurunanak College of Pharmacy, Nari, Kamptee road, Nagpur 440026, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).4045-49

4045-4049

1169

463