Volume 3 (2012) - Issue 10, October
PATHOPHYSIOLOGY OF NEUROPATHIC PAIN: A SYSTEMIC REVIEW
Neuropathic pain is considered as an inappropriate response caused by a lesion or dysfunction in the PNS or CNS). Neuropathic pain can manifest itself as either without a stimulus (stimulus-independent pain) and/ or as pain hypersensitivity elicited after a stimulus (stimulus-evoked pain). Stimulus-independent pain includes symptoms described by the patient such as (a) continuous, burning pain (b)...
ACTINIDIA DELICIOSA: A REVIEW
Actinidia deliciosa (A. Chev.) C. F. Liang et A. R. Ferguson is a sub-family of the genus Actinidia, which is also known as Chinese gooseberry, kiwifruit, yangtao, etc. in China, and consists of 55–60 species. The genus Actinidia is a dioecious plant and is widely distributed on the Asian continent. It is also native to China and most of the species are cultured in the southwest of China. Out of...
APPROACHES TO DEVELOPMENT OF SOLID – SELF MICRON EMULSIFYING DRUG DELIVERY SYSTEM: FORMULATION TECHNIQUES AND DOSAGE FORMS: A REVIEW
Solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation for therapeutic response. As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble. It is a great challenge for pharmaceutical scientist to convert those mole...
ROLE OF ADHESIVES IN TRANSDERMAL DRUG DELIVERY: A REVIEW
Transdermal drug delivery systems (TDDS) also commonly known as “patches” are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. The therapeutic performance of a transdermal delivery system (TDS) can be affected by the quality of contact between the patch and the skin. The adhesion of the TDS to the skin is obtained by using pressure-sensitiv...
DIABETIC CARDIOMYOPATHY: INSIGHTS INTO PATHOGENESIS, DIAGNOSTIC CHALLENGES, AND THERAPEUTIC OPTIONS
Diabetic cardiomyopathy is the presence of myocardial dysfunction in the absence of coronary artery disease and hypertension. Hyperglycemia seems to be central to the pathogenesis of diabetic cardiomyopathy and to trigger a series of maladaptive stimuli that result in myocardial fibrosis and collagen deposition. These processes are thought to be responsible for altered myocardial relaxation charac...
AN UPDATE OF PHARMACOLOGICAL ACTIVITY OF PSIDIUM GUAJAVA IN THE MANAGEMENT OF VARIOUS DISORDERS
In the recent years, the use of herbal products has been increasing in developing countries. Psidium guajava Linn. (Guava) family Myrtaceae is an important dietary plant used traditionally for medicinal purpose around the world. The fruit part of the guava is used because of its food and nutritional value but other part of the guava plant are used in the traditional system due to their medicinal p...
USE OF LIPOSOMES IN CANCER THERAPY: A REVIEW
Cancer is uncontrolled growth of abnormal cells in the body. The cells causing cancer are called malignant cells. There are so many means by which one can treat the cancer such as chemotherapy, radiation treatment, surgery, etc. With all these treatments there are some side effects as loss of hairs, living cells may get killed, for surgery skilled persons are required and chances of reoccurrences ...
VIROSOMES: A NOVEL VACCINATION TECHNOLOGY
Vaccine development has continuously shifted away from live attenuated or inactivated whole organisms. Although this approach having good efficacy but for improvement on comparison of risk/benefit ratio which needs improvement due to their highly complex compositions which result in safety concerns. As a consequence, a number of indications remained unadressed. The next generation vaccines represe...
NON ALCOHOLIC FATTY LIVER DISEASE: A BRIEF OVERVIEW
The occurrence of non-alcoholic fatty liver disease (NAFLD) is around 20-30% in the general population. NAFLD is usually asymptomatic, although a minority of patients may present with evidence of progressive liver injury with complications of cirrhosis, liver failure, and hepatocellular carcinoma. In spite of being common and potentially serious, relatively little is known about the natural histor...
RECENT APPROCHES OF “IMPURITY PROFILING” IN PHARMACEUTICAL ANALYSIS: A REVIEW
Impurity is something that is impure or makes something else impure. An impure substance may be defined as follows: a substance of interest mixed or impregnated with an extraneous or usually inferior substance, from the standpoint of its usage, the drug substance is compromised in terms of purity even if it contains another material with superior pharmacological or toxicological properties. The ...
ANTIBODY ENGINEERING AND IMMUNOCONJUGATES FOR CANCER THERAPY
In the past three decades, monoclonal antibodies have become increasingly important class of disease modifying drugs for numerous indications including cancer, inflammatory diseases, and viral infections. Antibody therapy can be used in a variety of ways either alone or combination with cytotoxic compounds. Molecular antibody engineering technologies coupled with advances allow the generation of b...
CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW. PART III; CRINUM ALKALOIDS: BELLADINE-, GALANTHAMINE-, LYCORENINE-, TAZETTINE-TYPE ALKALOIDS AND OTHER MINOR TYPES
Crinums occupy an important position within plants of family Amaryllidaceae, and many of them have been broadly used in traditional and ethnomedicines throughout the world. Due to their richness in bioactive phytoconstituents, Crinums have been subjected to extensive chemical, cytological and pharmacological investigations that focused chiefly on their alkaloidal content. Continuing our appraisal ...
ANTIDIABETIC PLANTS AND THEIR ACTIVE INGREDIENTS: A REVIEW
Diabetes mellitus is a lifestyle disorder that is rapidly becoming a major threat to populations all over the globe. Over the past 30 years, the status of diabetes has changed from being considered as a mild lifestyle disorder of the elderly to one of the major causes of morbidity and mortality, affecting people of all ages. India is slated to be the diabetic capital of the world, with 50.8 mill...
CAUSES AND CONDITIONS ASSOCIATED WITH REDUCED LEVEL OF VITAMIN B12: A REVIEW
Vitamin B12 plays an important role in building of genetic material, in development of normal red blood cells and in maintenance of nervous system. Major deficiency symptoms of Vitamin B12 include anemia and neurological disorders. The daily recommended intake of vitamin B12 for an adult is 1.5μg a day. Eating a diet containing required amount of vitamin B12 is the best way to treat the condition...
A REVIEW ON PARENTERAL CONTROLLED DRUG DELIVERY SYSTEM
The parenteral administration route is the most effective and common form of delivery for active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy a...
FORMULATION OF COATED TABLETS OF DRY HAWTHORN EXTRACT AND THE DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR EVALUATING IT’S IN VITRO DISSOLUTION
Extracts of hawthorn (Crateagus sp.) have been indicated in the treatment of cardiovascular diseases, however, tablets produced from dry extract due to a multiple of factors such as inconsistent botanical ingredients, moisture content and hygroscopicity turn to be hard with prolong disintegration. Dissolution test is increasingly being employed for the assessment of solid herbal medicinal dosage f...
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR SOME AZOLES IN PHARMACEUTICAL PREPARATION
A new, simple and rapid reversed-phase high-performance liquid chromatography (HPLC) method was developed and validated for the determination of some azoles drug (Ketoconazole, Isoconazole and Miconazole) in pharmaceutical dosage forms in Jordan market. The HPLC separation was achieved on a C18 BDS column (100 mm × 4.6 mm) using a mobile phase of acetonitrile and 0.05 M Ammonium Acetate buff...
ARTEMISIA DRACUNCULUS, PUNICA GRANATUM AND BERBERIS VULGARIS INHIBITORY EFFECTS ON PLATELET ADHESION AND COAGULATION FACTORS IN RATS
Excessive platelet activity is one of the most important factors responsible for the incidence of cardiovascular diseases and, also, play important role in coagulation cascade. In this study, the comparative effects of methanol extracts of three herbs on adhesion of the activated platelets to fibrinogen coated plates and clotting factors were investigated. Artemisia dracunculus, Punica granatum an...
ANALYSIS OF THE STRUCTURAL AND ULTRASTRUCTURAL ANATOMY OF SYMPHONIA GLOBULIFERA L. F. (CLUSIACEAE) LEAVES.
Symphonia globulifera L.f. (Anani) is an arboreal species, which occurs in the Amazon with antimalarial and antimicrobial properties, especially in the treatment of skin inflammations. It is also used as a general tonic and laxative for pregnant women and its sap/latex is used against rheumatism and tumors. The utilization of natural products from plant origin implies in pharmacobotanical quality ...
IMPLEMENTATION OF A NEW COURSE FOR THE PHARMACY PROGRAM AT THE CATHOLIC UNIVERSITY OF CUYO “HERBAL MEDICINES, NUTRACEUTICALS AND DIETARY SUPPLEMENTS”
The course on "Herbal Medicines, Nutraceuticals and Dietary Supplements” has been implemented among the new courses within the 2007 curriculum of the Pharmacy Program, School of Food, Biochemical and Pharmaceutical Sciences at the Catholic University of Cuyo, located in San Juan Province, Argentina. The main objective of the course is to provide students with the necessary tools to acquire kno...
SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MESALAMINE AND PREDNISOLONE IN COMBINED ORAL DOSAGE FORM
The objective of this study was to develop simple, precise, accurate, reproducible and economical vireodt's method for simultaneous estimation of mesalamine (MSM) and prednisolone (PRD) in combined oral dosage form. The method involved measurement of absorbance at two wavelengths, 332nm and 246nm, λmax of MSM and PRD, respectively in phosphate buffer (pH 7.4) with dimethyl formamide (DMF) as coso...
COMPARATIVE STUDY ON THE EFFECT OF DIFFERENT METHODS OF DRYING ON PHENOLICS CONTENT AND ANTIOXIDANT ACTIVITY OF SOME EDIBLE PLANTS
Antioxidants have important role in prevention and treatment of disorders and plants are considered as rich sources of radical scavenging compounds. Nowadays, many herbs are used in dried form which is possible to affect their antioxidant activity. In the present investigation, the effects of different drying methods on the antioxidant capacity and total phenolics content of some culinary plant sp...
EFFECTS OF VANADIUM COMPOUNDS ON GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS: A META-ANALYSIS OF COMPARATIVE STUDY ON RATS
Aim: To assess the effect of vanadium compounds on glycemic control in diabetic rats. Methods: Eligible studies were identified by searching two databases; one search engine was also used for search of articles from different data bases using standardized terms and Boolean logic. Statistical analysis was performed with Meta Analyst software. Results: 56 relevant studies were found but only 8...
ANTIMICROBIAL POTENTIAL OF CRUDE EXTRACTS AND ISOLATES OF ROOTS OF MIMOSA PUDICA LINN. COLLECTED FROM THE LOCALITY OF MOHUDA ENVIRON, GANJAM, ODISHA
A complete documentation of the ethno-biological information presently existing among the diverse communities is needed at an earliest so as to restore the traditional medicinal knowledge. Research to find out scientific evidence for claims by tribal healers on Indian herbs has been intensified as being evidenced from many cited literatures. Once these local ethno medical preparations are scien...
THE RATE OF THE PREVALENCE OF HIGH-RISK PREGNANCIES AND THE RESULTS ON PREGNANT MOTHERS AND THE EFFECT ON PARAMETERS AFTER THE BIRTH
Pregnancy causes large physiologic changes in most body systems and these changes may lead to ease or harden examining some events. The purpose of this study is to define the rate of risk in pregnant women and the results in mother and fetus and also to define the risk rate of pregnancy in pregnant women and its effect on parameters after birth in patients of Educational and Medical center of Gorg...
A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND NAPROXEN IN TABLET FORMULATION
The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent fl...
DESIGN, SYNTHESIS AND VIRTUAL SCREENING OF CERTAIN 2-PYRAZOLIN-5-ONE AND PYRAZOLIDINE-3, 5-DIONE DERIVATIVES AS POTENTIAL PPAR AGONISTS
In the quest for novel PPARg agonists as putative drugs for the treatment of type 2 diabetes, a new series of 2-pyrazolin-5-one and pyrazolidine-3, 5-dione derivatives, were designed and synthesized, as analogues to the anti-diabetic thiazolidinedione agents (TZDs). Extensive molecular modeling studies for the designed molecules were performed; including their compare-fit studies on the generate...
FORMULATION AND IN VITRO DISSOLUTION STUDIES OF SALBUTAMOL
Salbutamol is a potent anti-asthmatic agent, is a short-acting β2-adrenergic receptor agonist act. In the present study, an attempt has been made to prepare fast dissolving tablets of Salbutamol in the oral cavity with enhanced dissolution rate and to achieve better patient compliance. The tablets were prepared with four superdisintegrants e.g., Sodium starch glycolate, Cross-povidone, Cross-carm...
DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR ESTIMATION OF 6-GINGEROL IN HERBAL FORMULATIONS AND EXTRACTS
A simple, selective, precise and reliable HPTLC method of analysis has been developed and validated for estimation of 6-gingerol in extracts of dried rhizomes of Zingiber officinale and marketed formulations containing Ginger. The method employed TLC aluminium plates precoated with silica gel 60F 254 as stationary phase. The solvent system consisting of n-hexane:ether (40:60v/v). Densitometric ana...
SIMULTANEOUS ESTIMATION OF MEFENAMIC ACID AND DICYCLOMINE HYDROCHLORIDE BY SPECTROSCOPIC METHODS
A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method was developed and validated for the determination of Mefenamic acid and Dicyclomine hydrochloride in combined dosage form. Three different analytical methods, Absorption correction method, Differential derivative method, Simultaneous equation method were developed for estimation of Dicyclomine hydrochloride(10mg)...
COMPARATIVE ASSESSMENT OF MILK BORNE PATHOGENS AND THEIR ANTIBACTERIAL SENSITIVITY
Milk is considered as a highly nutritious and valuable human food, consumed by the people in a variety of different products. The present work is an effort to have a survey of number of bacteria present in different milk samples viz., Raw, Boiled, Pasteurized and Skimmed milk collected from local market of Haridwar and its adjoining areas by serial dilution method and the quality of milk assessed ...
POTENTIAL LARVICIDES IN NIGERIAN HERBAL RECIPES
Investigations into the larvicidal potential of crude extracts of ten Nigerian plants were carried out against the fourth instar larvae of Anopheles gambiae mosquito. The phytochemical screening revealed that both anthraquinones and cyanogenic glycosides were absent in all the plants. However, alkaloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids were either present or absent. ...
DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF CARVEDILOL USING SUBLIMATION TECHNIQUE
The purpose of the study was to design and evaluate fast dissolving carvedilol tablets using β-Cyclodextrin and superdisintegrants adopting sublimation technique. Tablets were prepared by direct compression method. Tablets were evaluated for their physico chemical properties, wetting time, disintegration, in-vitro release and stability studies. SEM analysis was carried out to determine the surfac...
VALIDATED HPTLC METHOD FOR ESTIMATION OF CURCUMIN CONTENT IN DIETARY SUPPLEMENT FORMULATION
The simple, accurate and precise HPTLC method was developed for quantification of curcumin content in dietary supplement formulation. In this method, individual curcuminoids (curcumin, demethoxy curcumin and bisdemethoxy curcumin) with piperine were resolved using mobile phase n-hexane: ethyl acetate: methanol: formic acid (8: 2: 1: 2-3 drops v/v) on a plate precoated with silica gel 60 F254 and q...
A COMPARATIVE ANALYSIS OF THE PHYTOCHEMICAL VARIABILITY OF ARBOREAL RUTACEAE MEMBERS
The accumulation tendencies of different classes of compounds within the related Rutaceae genera and species are well documented, considering different populations and plant individuals. Aegle marmelos is one species which has been largely exploited in India in indigenous systems of medicine as a potential herbal medicine for abdominal disorders. The species has been listed as Vulnerable due to it...
ASSESSMENT OF PRESCRIBERS ADHERENCE TO THE BASIC STANDARDS OF PRESCRIPTION ORDER WRITING IN SERBO AND ASSENDABO HEALTH CENTERS, JIMMA ZONE, SOUTH WEST ETHIOPIA
Background: Since prescribing is the first and foremost component in the process of using drugs, it is a vital element in rational drug use. The concept of rational prescribing requires that the prescriber follows correct and complete prescription writing. Objective: To assess prescribers adherence to the basic standards of prescription order writing in Serbo and Assendao health centers. Met...
ANTIMICROBIAL ACTIVITY OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF CASSIA ANGUSTIFOLIA VAHL- IN VITRO STUDY
The aim of the study was to evaluate and compare the antimicrobial activity of crude leaf extracts of Cassia angustifolia Vahl. The leaves of Cassia angustifolia Vahl. were taken from three different regions of India such as SR-1 from South India, SR-2 from Rajasthan and SR-3 from Haryana. Antimicrobial suspectibility testing of ethanolic and aqueous leaf extracts of Cassia angustifolia Vahl. were...
FORMULATION STRATEGY FOR DISSOLUTION ENHANCEMENT OF SIMVASTATIN
The present work aim was “Formulation Strategy for Dissolution Enhancement of Simvastatin”. Simvastatin is lipid lowering drug which is known as HMG CoA reductase. The objective of this study was to increase the solubility of poorly water soluble drug, namely simvastatin, by the formation of solid dispersion and complex and also using the microwave induction technique on these formations. For ...
INVESTIGATIONS OF PHYSICO-CHEMICAL STATUS OF GROUND WATER OF SINGRAULI DISTRICT, MADHYA PRADESH, INDIA
Ground water is the most preferred water source in current scenario. Once believed to be safe from pollution as it is available many band below the surface, is now provided to be prone to pollution by research investigators. Various causes associated for the contamination of ground water. The major cause of the contamination of ground water may be due to improper disposal of industrial waste. The ...
EFFECT OF CEREBELLAR FASTIGIAL NUCLEUS LESION ON IMMUNITY IN WISTAR ALBINO RATS
The aim of the present study was to investigate the role of cerebellum in immunomodulation as cerebellum was thought traditionally to play an important role in voluntary motor activities. Rats weighing about 200-220 gm were subjected to bilateral electrolytic lesion of fastigial nucleus and following immune parameters were assessed- leucocyte migration inhibition test, foot pad thickness, antibody...
NEUROPROTECTIVE EFFECT OF CURCUMIN WITH A FIXATOR OF ABSORPTION AGAINST BOTH ALUMINIUM NEUROTOXICITY AND ALZHEIMER’S DISEASE (EXPERIMENTAL STUDIES IN MICE)
The versatility of Aluminium chemistry will ensure its burgeoning use in the future in all manner of applications. This very same chemistry will also ensure its increased biological availability in all biota including Man. We do not know enough about the biological chemistry of a chronic and sub-acute exposure to Aluminium to be able to predict its impact on human health. Although the hypothesis o...
POLYSACCHARIDE MATRIX TABLET FOR COLON SPECIFIC DRUG DELIVERY
The objective of the present study was to prepare a matrix tablet for colon targeting. Natural gaums (guar gum and xanthan gum) were used for the preparation of colon targeted drug delivery system. Different concentrations of guar gum and xanthan gum and their combinations were tried for the purpose. The prepared tablets were evaluated for in-process parameters as well as colon targeting character...
ANTIDIARRHOEAL ACTIVITY OF LEAVES OF ACORUS CALAMUS
In developing countries, the majority of people living in rural areas almost exclusively use traditional medicines to treat all sorts of diseases including diarrhea. Many plants namely Andrographis paniculata, Acacia catechu, Acacia chandra, Terminalia chebula, Pterocarpus marsapium, Cassia auriculata etc. available in india are used in traditional folklore medicine for the treatment of diarrhea. ...
BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND ZN(II) COMPLEXES WITH SCHIFF BASE 4, 4-(1, 4-PHENYLENE BIS(AZAN-1-YL-1- YLIDENE)) BIS(METHAN-1-YL-1-1-YLIDENE)-1, 2-DIOL. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION
Condensation reaction of 1, 4-phenylene diamine and Protochatechu aldehyde in 1:2 molar ratio resulted in the formation of new Schiff base ligand 4, 4-(1,4-phenylene bis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-1-ylidene)-1, 2-diol; (H4L) .From the direct reaction of the ligand (1) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II)nitrates in 2M:1L molar ratio, the five new neutral comp...
ANTI-DIABETIC ACTIVITY OF METHANOLIC AND ETHYL ACETATE EXTRACTS OF WRIGHTIA TINCTORIA R.BR. FRUIT
The present work was undertaken to investigate various extracts of fruit of Wrightia tinctoria (F-Apocyanacea) for anti-diabetic activity in alloxan induced diabetic rats. A comparison was made between the action of extracts and known anti-diabetic drug glibenclamide (10mg/kg body weight). Oral administration of methanolic extract at a dose of 300 mg/kg/b. wt and ethyl acetate extract at a dose of...
DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF ROSUVASTATIN CALCIUM AND ASPIRIN IN CAPSULE DOSAGE FORM
This paper described validated high performance thin layer liquid chromatographic (HPTLC) method for estimation of Rosuvastatin Calcium (ROSU) and Aspirin (ASP) in capsule dosage form. The method involved separation of components by TLC on a precoated silica gel 60 F254 using a mixture of n-Hexane: Acetone: Ethyl acetate: Formic acid (6:3:1:0.2 v/v) as a mobile phase. Detection of spots was carrie...
QUANTITATIVE ANALYSIS OF PARACETAMOL AND DICLOFENAC IN COMBINED DOSAGE FORM BY FIRST DERIVATIVE AND SIMULTANEOUS EQUATION METHOD IN APPLICATION TO THE DETERMINATION OF DISSOLUTION STUDY
Two simple, economical, precise, and accurate methods are described for the simultaneous determination of Paracetamol and Diclofenac in combined tablet dosage form. The first method is first- order derivative zero crossing method. The first order derivative absorption at 275.6 nm (zero cross point of Diclofenac) was used for Paracetamol and 242.69 nm (zero cross point of Paracetamol) for Diclo...
FORMULATION OF OIL CONTAINING PLUCHEA LANCEOLATA EXTRACT OBTAINED THROUGH DIFFERENT ORGANIC SOLVENTS AND EVALUATION OF ITS ANTI-INFLAMMATORY ACTIVITY BY TOPICAL APPLICATION
Pluchea lanceolata has been used in massage oil as well as in traditional ayurveda as a potent pain reliever. The traditional Method of obtaining oil is simply based on taking water as the medium for extraction. The water extract obtained is then boiled with oil, till the water is completely evaporated. Here, our aim is to replace water by different organic solvents and obtain oil which has much b...
BARRIERS TO IMPLEMENTATION OF PERFORMANCE-BASED MANAGEMENT PRACTICES IN PHARMACIES IN A DEVELOPING COUNTRY
The objective of this study was to conduct a survey and determine the barriers to implement performance-based management in pharmacies in Trinidad. PBM is defined as “a systematic approach to performance improvement through an on-going process of establishing strategic performance objectives, measuring performance, collecting, analyzing, reviewing, and reporting performance data, and using that ...
EFFECT OF NATURAL AND ARTIFICIAL SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING DICLOFENAC TABLET
FDTs are designed to disintegrate rapidly on contact with saliva and enables oral administration without water or chewing, these formulations offer increased convenience and ease of administration with the potential to improve patient compliance, particularly in certain populations, where swallowing of conventional solid oral dosage forms presents difficulties. In the present study, the effect of ...
IDENTIFICATION OF SPECIFIC MUTATIONS IN HUMAN RAS GENE
Cancer is a group of disease characterized by unregulated cell growth and spread of cells from site of origin to other sites in body. Two main genetic changes lead to cancer they are inactivation of tumour suppressor gene and activation of proto-oncogene. Ras gene is a proto-oncogene, when this gene activated it stimulates signalling pathway and that causes unregulated proliferation of cells. Ras ...
DESIGN AND OPTIMIZATION OF CONTROLLED RELEASE OCULAR INSERTS OF DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE FOR TREATMENT OF GLAUCOMA
Goal of the present investigation was to formulate ocular inserts of dorzolamide hydrochloride and timolol maleate for the treatment of glaucoma. Ocular inserts of dorzolamide hydrochloride and timolol maleate were prepared using different polymers ethylcellulose, Eudragit RL 100, and Eudragit RS100 by solvent casting method with an objective to increasing the contact time, achieving controlled re...
THE EFFECT OF ELICITORS ON THE PRODUCTION OF VASICINE FROM JUSTICIA ADHATODA L. CELL SUSPENSION CULTURES
In this study, α-naphthyl acetic acid and mannitol were used as elicitors to improve the productivity of useful metabolite, vasicine for archiving high concentration in Justicia adhatoda L. cell suspension cultures. When the cells were treated with 3mg 100 ml-1 suspension of α-naphthyl acetic acid, the vasicine concentration was increased by 1.65 mg ml-1 in 15 days culture compared to untrea...
PERMEATION STUDIES OF PIOGLITAZONE HCL FROM FICUS CARICA FRUIT MUCILAGE MATRIX TRANSDERMAL PATCHES
The main purpose of the present study was to develop matrix moderated transdermal patches of Pioglitazone HCl using various ratios of Ficus carica fruit mucilage. Physical parameters such as moisture content, moisture uptake, tensile strength, elongation and folding endurance were evaluated. The matrix type transdermal patches were prepared using Pioglitazone HCl with Ficus carica fruit mucilage b...
CHEMICAL EXAMINATION OF A NEW ALLELOCHEMICAL FROM STEMS OF GLOSSOCARDIA BOSVALLIA DC.
Glossocardia bosvallia DC.1-3 belongs to family Composite which is commonly known as “Patthar-suva or seri” in Hindi. It is found almost throughout in India and Deccan Peninsula. It is a small annual herb, 10-20 cm tall. The tribal inhabitants of western Maharashtra use a decoction of the plant as febrifuge. It has a bitter taste and fennel like odor. Besides serving as a medicinal plant Pi...
UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TELMISARTAN IN BULK AND TABLET DOSAGE FORM
A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The spectra of Telmisartan in 0.1 N NaOH and distilled water (20:80) shows λmax at 234 nm and estimation was carried out by A (1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2= 0.999) over the concentrat...
FORMULATION, TASTE MASKING AND EVALUATION OF ALMOTRIPTAN ORAL DISINTEGRATING TABLETS
The aim of the present study is to formulate and evaluate taste masked Almotriptan orally disintegrating tablet by using different taste masking agents and different superdisintegrants in different ratios, Almotriptan is a triptan class anti-migraine drug with rapid action, highest bioavailability and low side effects compared to other triptan class of drugs used in the treatment of migraine, Thus...
COMPARISON OF VARIOUS NATURAL SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING CARVEDILOL TABLET
In the present investigation, fast dissolving tablets of Carvedilol were formulated by using various natural superdisintegrant like Plantago ovata, Lepidium sativum, Fenugreek and Guar gum. A Direct compression method was used to prepare fast dissolving tablets containing Carvedilol as a model drug using natural superdisintegrants. Prepared formulations were evaluated for Precompression parameters...
ANTI-INFLAMMATORY ACTIVITY OF WHOLE PLANT OF POLYGALA ROSMARINIFOLIA WIGHT & ARN (POLYGALACEAE)
In the present study, Polygala rosmarinifolia whole plant was extracted with ethanol and evaluated for anti-inflammatory activity in rats using a carrageenan induced paw edema method. Ethanol extract exhibits potent anti-inflammatory activity at 200mg/kg at 3rd hr after administration is compared with reference standard drug, Indomethacin. Observed pharmacological activity in the present study pro...
STUDY OF ANTIBIOTIC SUSCEPTIBILITY TEST OF MODERN GENERATION OF DRUGS AGAINST UPPER RESPIRATORY TRACT PATHOGENS
Nasal infection or sinusitis is an inflammation of nasal passages caused by both viral and bacteriological pathogens. Antimicrobial resistance has universally recognized as growing problem concern about suitable therapy for nasal infection. The study was aimed at determining the prevalence and antimicrobial susceptibility against nasal infecting microorganisms. 50 clinical samples were taken from ...
VARIANTS OF ORAL GLUCOSE TOLERANCE TEST (OGTT) CURVE IN GESTATIONAL DIABETES MELLITUS (GDM)
Objective: Gestational diabetes mellitus is defined as “carbohydrate intolerance resulting in hyperglycemia of variable severity with onset or first recognition during pregnancy, whether or not insulin is used and regardless of whether diabetes persists after pregnancy. There is evidence that asymptomatic hyperglycemia during pregnancy leads to important morbidity in the mother and foetus. Hence...
THE ROLE OF INTRAVENOUS AMINO ACID INFUSION IN OLIGOHYDRAMNIOS
Oligohydramnios means the fetus is in a compromised condition. Ante partum amniotic fluid index (A.F.I.) assessment is one of the reliable, good predictor and standard technique for assessment of fetal well-being in antenatal period. In the present study 25 cases of Oligohydramnios in the third trimester were given intravenous amino acid in 1000cc of 10% fructodex drip on 1st day and the amino aci...
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY USING HIBISCUS ROSA – SINENSIS MUCILAGE AND MODIFIED GUM KARAYA
In the present study, natural gums (Hibiscus rosa – sinensis mucilage and Modified gum karaya) was investigated as superdisintegrants for use in fast dissolving tablet formulations containing amlodipine besylate. Fast dissolving tablets of amlodipine besylate was formulated using different concentrations (2, 4, 6, 8, 10) of natural superdisintegrant viz; Hibiscus Rosa – sinensis mucilage and m...
DRUG USE EVALUATION OF BRONCHODIALATORS IN PAEDIATRICS IN A TERTIARY CARE HOSPITAL
The use of bronchodilators has been increasing for the past few decades. The literatures have reported a high rate of adverse events. It has also been found out that beta-agonists are associated with an increased morbidity and mortality rate. Respiratory tolerance develops due to regular use of beta-agonists, which are widely prescribed in asthma and bronchiolitis also is of major concern. Obje...
PHYTOCHEMICAL CHARACTERISATION AND PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACT OF AVICENNIA ALBA
The history of herbal medicines is as old as civilization. For this purpose of ascertaining the phytochemical constituents, the present work was performed into the phytochemical investigation of the plant Avicenna alba. Separation and isolation of the constituents of interest, characterization of isolated compounds and investigation of the biosynthetic pathways of the particular pathway and quanti...
VARIED ANTI- INFLAMMATORY ACTIVITY OF INDOMETHACIN IN DIFFERENT EXPERIMENTAL ANIMAL MODELS
OBJECTIVE: To evaluate the anti-inflammatory activity of indomethacin in different experimental anti-inflammatory animal models METHODS: Swiss albino rats weighing around 150 g – 250 g of either sex were randomly selected and divided into 6 groups (n=6) for 3 models, each having control and Standard . Materials used are Carrageenan, turpentine, Cotton pellets, Mercury and water plethysmo...
DEVELOPMENT AND VALIDATION OF RATIO DERIVATIVE SPECTROPHOTOMETRIC FOR SIMULTANEOUS ESTIMATION OF METOLAZONE AND SPIRONOLACTONE IN PHARMACEUTICAL DOSAGE FORM
In the present work for the simultaneous estimation of Metolazone (METO) and Spironolactone (SPI) Ratio Derivative Spectrophotometric method have been developed. In this method the overlapping spectra of Metolazone and Spironolactone were well resolved by making use of the first-derivative of the ratios of their direct absorption spectra. Methanol:water (1:4) was used as solvent for the method. Am...
FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE PULSATILE DRUG DELIVERY SYSTEM FOR CHRONO BIOLOGICAL DISORDER: ANTI HYPERTENSION
The objective of the present study was to develop and evaluate an oral pulsatile drug delivery system to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined log time of 5 hrs (+ 0.25 hrs). The basic design of the pulse in cap formulation of metoprolol provides time controlled release to treat the nocturnal symptoms of hypertension and angina pectoris. The ...
STUDY OF ANTIATHEROSCLEROTIC ACTIVITY OF POLYHERBAL PREPARATION USING RAT AS AN EXPERIMENTAL ANIMAL MODEL
Atherosclerosis is one of the risk factors for coronary artery disease. The present study highlights the antiatherosclerotic activity of Methanolic extract of polyherbal preparation in experimentally induced atherosclerotic rats. Atherosclerosis was developed in male Albino Wistar rats, which were randomly divided into five groups of six animals each; by feeding with high cholesterol diet for 21 d...
HERBAL PRODUCT REALIZATION IN ACCORDANCE WITH WHO AND ISO GUIDELINES
Background: Following the Alma-Ata Declaration of 1978, the World Health Organization (WHO) began the issuance of guidelines for developing standardized herbal preparations from Traditional Medicine (TM). Similarly in 1987, the International Organization for Standardization (ISO) launched the most anticipated industrial standard (ISO 9001) in world history. The seventh (7th) clause of ISO 9001’s...
FORMULATION AND EVALUATION OF STAVUDINE ORAL DISINTEGRATION TABLETS
Stavudine an anti-retroviral drug is used for treating HIV now-a-days. The present approach aims to formulate an orally disintegrating tablet of stavudine for better patient compliance and bypassing the hepatic metabolism. In order to have an orally disintegrating tablet of stavudine, there is a need to mask the bitter taste. For the masking of bitter taste mannitol is used as taste masking agent....
IDENTIFICATION AND ANTIMICROBIAL ACTIVITY OF SAPONIN FRACTION FROM THE LEAVES OF BARLERIA CRISTATA L.
A simple HPTLC method was used to determine the saponin profile of Barleria cristata L. crude leaf extract. The antimicrobial activity of saponin fraction from the leaves of Barleria cristata L. was studied in-vitro against four bacterial species and four fungal species by agar disc diffusion method. Klebsiella Pneumonia, Staphylococcus aureus, E. coli, Aspergillus parasites were the most inhibite...
A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND NAPROXEN IN TABLET FORMULATION
The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 μm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent fl...