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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 3 (2012) - Issue 8, August

Review Articles

 
Title
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1.

AUTHENTICATION METHODS FOR DRUGS USED IN AYURVEDA, SIDDHA AND UNANI SYSTEMS OF MEDICINE: AN OVERVIEW

Traditional systems of medicine in India include Ayurveda,Yoga, Naturopathy, Unani and Siddha. Among them Ayurveda, Siddha and Unani systems (ASU) use plants, minerals and animal products as main drugs to cure various ailments. There has been a boom in the usage of ASU drugs and export is appreciably high in the last two decades. ASU drugs may vary in composition and properties, unlike conventiona...

S. Sudha Revathy*, R. Rathinamala, M. Murugesan

Department of Gunapadam, National Institute of Siddha, Tambaram Sanatorium, Chennai 47, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2352-2361

2352-2361

6234

1191

2.

OPTIMIZATION TECHNIQUES IN TRANSDERMAL DRUG DELIVERY SYSTEM

Transdermal drug technology specialists are continuing to search for new methods that can effectively and painlessly deliver larger molecules in therapeutic quantities to overcome the difficulties associated with the oral route. Transdermal Drug Delivery System (TDDS) is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin is an effective medium ...

Shikha Deshwal* and Navneet Verma

Department of Pharmaceutics, College of Pharmacy, IFTM, Delhi Road, Moradabad- 244 001, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2362-70

2362-2370

3103

759

3.

A REVIEW ON METABOLIC SYNDROME: A NEW ENEMY OF PUBLIC HEALTH

Metabolic Syndrome is a cluster of several cardiovascular risk factors that include glucose intolerance, central obesity, dyslipidemia, and hypertension. The public health impact of this syndrome is weighty; given it is a primary risk factor for cardiovascular diseases, obstructive sleep apnea, and type II diabetes. This current plight is further underscored by recently emerging evidence that Meta...

Bhagat Singh Jaiswal

SOS in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2371-75

2371-2375

1081

323

4.

MODIFIED RELEASE FORMULATIONS TO ACHIEVE THE QUALITY TARGET PRODUCT PROFILE (QTPP)

Modified Release (MR) Formulations have a modification in the release mechanism. Modified release dosage forms are developed by altering drug absorption or the site of drug release in order to achieve predetermined clinical objectives. Modified drug release from dosage forms is complemented by the allied processes of drug design, of dosage administration, and of membrane transport and absorption o...

Mithilesh Kumar Jha

Department of Pharmacy, School of Health and Allied Sciences, Pokhara University, Lekhnath-12, Kaski, Nepal

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2376-86

2376-2386

1526

787

5.

SOME EXPERIMENTALLY PROVED HERBS IN PEPTIC ULCER DISEASE

Peptic ulcer is a worldwide health problem because of its high morbidity, mortality and enormous financial implication. An estimated 15,000 deaths per year occur as a consequence of complicated PUD.A large number of drugs for peptic ulcer disease are available in mainstream medicine but they are associated with numerous side effects like arrhythmias, impotence, gynaecomastia and haematopoietic cha...

Shagufta Nikhat , Javed Ahmad Khan* and Ghufran Ahmad

Assistant Professor, Department of Ilmul Advia, Deoband Unani Medical College, Deoband, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2387-92

2387-2392

1494

485

6.

DESIGN, EVALUATION AND RECENT TRENDS IN TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW

Transdermal drug delivery system (TDDS) is topically administered dosage form in the form of patches which deliver drugs for systemic effects at a predetermined and controlled rate. It works very simply in which drug is applied inside the patch and it is worn on skin for long period of time. By this constant concentration of drug remain in blood for long time. Polymer matrix, drug, permeation enha...

Mudavath Hanumanaik*, Umesh Patil, Gaurav Kumar, Sandeep Kumar Patel, Ishwar Singh, Kishor Jadatkar

Department of Pharmaceutics, KLE’S College of Pharmacy, Vidyanagar, Hubli- 580031, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2393-06

2393-2406

4241

1360

7.

GOLDEN EYE GRASS – A MAGICAL REMEDY BY NATURE

From the dawn of civilization, medicinal plants are known to be part of human society to combat diseases. In recent times, focus on plant research has increased all over the world and various evidences have been collected to show immense potential of medicinal plants used in various traditional systems. India officially recognizes over 3000 plants for their medicinal value. It is generally estimat...

Nidhi Soni*, V. K. Lal , Shikha Agrawal and Hemlata Verma

Sr. Lecturer, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2407-20

2407-2420

2689

1309

8.

PHYTOCHEMICAL AND BIOLOGICAL EVALUATION OF VITEX NEGUNDO LINN: A REVIEW

Vitex negundo Linn. belong to family Verbenaceae. It is an important medicinal plant.Literaturesurvey of V. negundo revealed the presence of  different classes of natural products including essential oil,triterpenes, diterpenes, sesquiterpenes, lignan, flavonoids,flavones glycosides, iridoid glycosides, and stilbene derivative. The plant is traditionally reported for its use for the treatment of ...

Zahoor Ullah*, Riaz Ullah , Azhar-ul-Haq Ali Shah , Ijaz Ahmad and Sajjad Haider

Department of Chemical Engineering, College of Engineering, King Saud University, P.O BOX 800, Riyadh 11421, Saudi Arabia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2421-31

2421-2431

2851

1112

9.

NYCTANTHES ARBOR-TRISTIS A HERBAL PANACEA Pr

Nyctanthes arbor-tristis Linn. (NAT) is well known Indian medicinal plant.  The plant is used in Ayurveda for various pharmacological actions such as anti-arthritic, antispasmodic, antibacterial, anti-inflammatory, immunostimulant, antidiabetic, hepatoprotective, antiarthritic, antioxidant, antimicrobial, antihelmintic, antileishmanial, antiviral, CNS depressant. The present review discusses phar...

Milind M. Meshram*, Swatee B. Rangari , Shashank B Kshirsagar , Suraj Gajbhiye , Madhuri R. Trivedi and Rajkumari S. Sahane

Department of Pharmacology, Sinhgad College of Pharmacy 1, Vadgaon (Bk), Pune-41, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2432-40

2432-2440

2163

1209

10.

SMEDDS: A NOVEL APPROACH FOR LIPOPHILIC DRUGS

The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility and less bioavailability. Self-micro emulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formul...

Vikas Sharma, Jatinder Singh, Bhawandeep Gill* and S.L. Harikumar

Rayat and Bahra Institute of Pharmacy, Sahauran, Mohali- 140 103, Panjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2441-50

2441-2450

2244

1027

11.

A REVIEW ON SOME NEPHROPROTECTIVE MEDICINAL PLANTS

Nephrotoxicity is one of the most common kidney problems and occurs when body is exposed to a drug or toxin. A number of therapeutic agents can adversely affect the kidney resulting in acute renal failure, chronic interstitial nephritis and nephritic syndrome because increasing number of potent therapeutic drugs like aminoglycoside antibiotics, chemotherapeutic agents and NSAIDS. Nephroprotective ...

Kanchan Gaikwad*, Pradeep Dagle, Pushpalata Choughule, Y. M. Joshi, Vilasrao Kadam

Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur Navi Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2451-54

2451-2454

4129

1966

12.

NOVEL PARADIGMS IN MUCOADHESIVE DRUG DELIVERY SYSTEM

Mucoadhesion is a field of current interest in the design of drug delivery systems. Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Mucoadhesive drug delivery system may be designed to enable prolonged residence time of the dosage form at the site of application or absorption and facilitate an intimate contact of the dosage form w...

Deepak Sharma*, Mankaran Singh, Dinesh Kumar and Gurmeet Singh

CT Institute of Pharmaceutical Sciences, Shahpur, P.O- Udopur, Near Lambra, Jalandhar -144020, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2455-71

2455-2471

1952

459

13.

OVERVIEW OF NEW ANTI TB DRUGS

The emergence of multi-drug-resistant strains of M. tuberculosis makes it  necessary for the discovery of new drugs, and also implement other modalities of treatment. Eperezolid and linezolid  are  oxalidinones which are in phase II clinical trials. Other oxalidinones like AZD5847 and  PNU100480  are being evaluated in a phase I trials.  Regimens based on a higher dose of rifampin in humans ...

P. Yadav*, P. Deolekar , V. Kanase and S. Mishra

Associate Professor in Pharmacology, Dr. D. Y. Patil Medical College, Navi Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2472-81

2472-2481

1994

737

14.

DILLENIA INDICA (OUTENGA) AS ANTI-DIABETIC HERB FOUND IN ASSAM: A REVIEW

Dillenia Indica, commonly known as elephant apple and locally known as outenga, is the handsome evergreen tree grows in the moist forest of sub-Himalayan region to Assam. The fruit grows in abundance and due to lack of knowledge and technical knowledge; most of these fruits are wasted. In Assam, traditionally the unripe fruits are used to make curries because of its sour taste and ripe fruits are ...

Apurba Talukdar*, Nayan Talukdar , Satyendra Deka and Bhargab Jyoti Sahariah

Assistant Professor, Department of Pharmacy, Assam down town University, Sankar Madhab Path, Gandhinagar, Panikhaiti, Guwahati- 781026, Assam, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2482-86

2482-2486

4837

1593

15.

A REVIEW ON ANTIULCER ACTIVITY

Over the past decades, herbal medicine has become a thing of global significance with medicinal and economic implications. Wide spread use of herbs throughout the globe has raised serious concerns over its quality, safety, and efficacy. Our investigation showed that these investigated medicinal plants could prevent ulcer in a dose-dependent manner. Histological studies revealed that these medicina...

Pradip Kumar Maury*, S.K. Jain, Nand Lal and Shashi Alok

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2487-93

2487-2493

2811

1259

16.

A REVIEW ON ARGEMONE MEXICANA LINN. – AN INDIAN MEDICINAL PLANT

Argemone mexicana Linn has been reported to posses anti microbial, cytotoxic, anti malarial and other pharmacological activity. Alkaloids, amino acids, phenolicsand fatty acids are the main constituents isolated from the plant. The present article reviews the pharmacological and phytochemical work done on the plant and determines a scientific base for novel study for future research to establish t...

Saurabh Rajvaidhya*, B.P. Nagori, G.K. singh, B.K. Dubey, Prashant Desai and Sanjay Jain

T.I.T. College of Pharmacy, Bhopal, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2494-01

2494-2501

3399

686

17.

CURRENT STATUS AND FUTURE INNOVATIONS IN TRANSDERMAL DRUG DELIVERY

Transdermal drug delivery system (TDDS) in comparison to conventional system offers sustained drug release as well as decrease the intensity of action and decrease in the side effects associated with conventional therapy. Presently only about 40 products of more than 20 drug molecules are available in market. The barrier property of the stratum corneum is the main obstructer in the release of drug...

Shalini Chhabaria*, Ankur Namdeo, Rajat Kheri, Gaurav Saraogi and Akhilesh Singhai

Lakshmi Narain College of Pharmacy, Kalchuri Nagar Raisen Road, Bhopal- 462 021, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2502-09

2502-2509

2339

720

Research Articles

 
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18.

INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A (HMG Co-A) REDUCTASE IN LIVER MICROSOMES BY MORINGA OLEIFERA L. POLYPHENOLS

Phytochemicals are the bioactive components present at micro level in our daily diet, especially the phenolic antioxidants, contribute to the prevention of cardiovascular and other degenerative diseases.  Moringa oleifera (MO) leaves polyphenols effect on  the activity of 3-hydroxy-3-methylglutaryl Coenzyme A (HMG CoA)  reductase was studied using a spectrophotometric assay based on the stoichi...

Vanitha Reddy P. , Faiyaz Ahmed and Asna Urooj*

Associate Professor, Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangotri, Mysore 570006, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2510-16

2510-2516

1702

603

19.

VOLTAMMETRIC DETERMINATION OF OLOPATADINE HYDROCHLORIDE IN BULK DRUG FORM AND PHARMACEUTICAL FORMULATIONS

The voltammetric behavior of olopatadine was investigated at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of carbon-carbon double bond. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetr...

N.Y. Sreedhar*, A. Sreenivasulu, M. Sunil Kumar and M. Nagaraju

Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2517-21

2517-2521

1210

365

20.

ANTIOXIDANT EFFECT OF ALOE VERA IN EXPERIMENTALLY INDUCED DIABETES MELLITUS

The aim of the present study was to evaluate antidiabetic and antioxidant potential of Aloe vera (AV) in alloxan induced diabetes in albino rabbits. Experimental Diabetes was induced in rabbits with alloxan(80mg/Kg body weight)and animals showing fasting blood glucose levels more than 250mg/dl were considered as diabetics  and divided into four groups of six each (n=6).    Group I: Normal cont...

Jyoti Sethi*, Anupama Gupta , Sushma Sood , Kiran Dahiya , Gajender Singh and Rajesh Gupta

Associate Professor (Physiology), Pt B D Sharma PGIMS Rohtak- 124001, Haryana India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2522-26

2522-2526

1496

443

21.

INTRODUCTION OF INTEGRATED TEACHING AND ITS COMPARISON WITH OTHER TEACHING METHODS IN PHARMACOLOGY FOR UNDER GRADUATES

Background and Purpose: Integrated teaching is new in pharmacology. In the present study, evaluation and comparison of integrated teaching, conventional theory teaching and tutorial has been done. Material and methods: Ten pre and post tests were conducted each for integrated teaching, theory class and tutorial for 126 students. Student’s attitude towards these teaching methods and bedside cl...

Suneel Ishwar Majagi

Department of Pharmacology, J.N. Medical College, Nehru Nagar, Belgaum- 590010, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2527-34

2527-2534

1266

339

22.

CARDIO-PROTECTIVE EFFECT OF ALCOHOLIC EXTRACT OF CYPERUS ROTUNDUS RHIZOME ON ISOPROTERENOL-INDUCED MYOCARDIAL NECROSIS IN RATS

The study was designed to scientifically evaluate the effect of alchoholic extract of Cyperus rotundus rhizomes, a traditional medicinal herb, on isoproterenol-induce myocardial necrosis in rats model. The albino wistar rats were divided into five different groups with six animal in each group. Group I serves as a control group, group II were given isoproterenol (85 mg/kg s.c) for 2 days while Gro...

Syed Mehdi Raza*, Vipra Tomar and H.H. Siddiqui

Integral University, Lucknow, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2535-38

2535-2538

1184

546

23.

ANTI ULCER EFFECT OF BASELLA ALBA LEAF EXTRACT IN ASPIRIN INDUCED ALBINO RATS

The present study was designed to evaluate the anti ulcer effect of Basella alba in aspirin induced ulcerated rats. Aspirin  induced ulcer was revealed by increased ulcer index, decreased gastric pH, increase in the levels of pepsin, Thio barbituric acid reactive substance (TBARS). Lipid hydroperoxides and decrease in the levels of enzymatic and non enzymatic antioxidants. Treatment with the plan...

P. Venkatalakshmi* and V. Senthamaraiselvi

Department of Biochemistry, S.T.E.T. Women’s College, Mannargudi- 614 001, Tiruvarur, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2539-42

2539-2542

1575

477

24.

EVALUATION OF IN-VITRO ANTIOXIDANT ACTIVITY OF PANCHAGAVYA: A TRADITIONAL AYURVEDIC PREPARATION

Panchagavya, a classical Ayurvedic preparation, was evaluated for its antioxidant potential by HPTLC-DPPH bioautography method as well as assays for Ferric reducing antioxidant power (FRAP), DPPH – free radical scavenging activity (DPPH) and Superoxide radical scavenging activity. In addition total phenolic content was also estimated which was in fairly good amount. HPTLC-DPPH bioautography stud...

Arun Athavale, Nikhil Jirankalgikar, Pankaj Nariya and Subrata De*

RMD Research and Development Center, Waghaldhara, Dist-Valsad- 396 375, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2543-49

2543-2549

3166

1253

25.

OPTIMISATION OF TYROSINE-BASED LEAD MOLECULES CAPABLE OF MODULATION OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

The peroxisome proliferator-activated receptor gamma (PPARγ) agonist rosiglitazone has recently been withdrawn from the European market and its use has been restricted in the US due to its undesirable effects which were considered to outweigh its benefits.  Literature indicates that there are two agonist bound conformations of the PPARγ as exemplified by its binding to rosiglitazone (PDB ID; 1F...

J. Ciantar*, C. Shoemake , C. Mangani , L.M. Azzopardi and A Serracino Inglott

Pharmacy Department, Faculty of Medicine and Surgery, University of Malta, Msida MSD 2080, Malta

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2550-61

2550-2561

1136

300

26.

ACECLOFENAC ENCAPSULATED ETHANOLIC NANO-VESICLES FOR EFFECTIVE TREATMENT OF OSTEOARTHRITIS

In the present study, ethanolic nanovesicles of Aceclofenac developed for the site specific delivery to joints for effective treatment of osteoarthritis. Ethanolic nano-vesicles were prepared by solvent dispersion method. Vesicles were characterized for vesicular size, surface morphology, size and size distribution, zeta potential, entrapment efficiency. Formulations were also evaluated for drug-v...

Arvinder Kaur*, Sunil K. Jain and Ravi S. Pandey

Pharmaceutics Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495 009, Chhattisgarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2562-67

2562-2567

1306

387

27.

EVALUATION OF JASMINUM GRANDIFLORUM FOR HEPATOPROTECTIVE ACTIVITY IN ISONIAZID INDUCED LIVER DAMAGE

Objectives: The study was designed to evaluate hepatoprotective effect of the ethanolic leaves extract of Jasminum grandiflorum (JG) in Isoniazid (INH) induced hepatotoxicity in wistar albino rats. Materials and methods: Mature leaves of JG were collected, authenticated and subjected to successive ethanolic extraction. Hepatic damage was induced in wistar rats by administering INH (54mg/kg, p.o...

Netranjali Dhamal, Mihir Patel and Shrikant Pawar*

Department of Pharmacology, Sinhgad Technical Education Society’s Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune-411048, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2568-73

2568-2573

1531

576

28.

ANTIMICROBIAL ACTIVITY AND BIODEGRADING ENZYMES OF ENDOPHYTIC FUNGI FROM EUCALYPTUS

A total of thirty endophytic fungi were isolated from leaves and twigs of Eucalyptus globulus and Eucalyptus citriodora. Among thirty endophytic fungal isolates, four (P3MT1, P3MT2, OP4MT2 and P7ML2) are consistently producing compounds which are inhibiting Pseudomonas aeroginosa, Mycobacterium smegmatis  and Candida albicans even after 10 generations tested under dual culture, well diffusion and...

L. Sathish, N. Pavithra and K. Ananda*

Department of Biological Sciences, Poornaprajna Institute of Scientific Research, Post Bidalur, Devanahalli Taluk, Bangalore- 562110, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2574-83

2574-2583

2131

905

29.

DEVELOPMENT AND VALIDATION OF DUAL WAVELENGTH UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND DESLORATADINE HYDROCHLORIDE IN THEIR COMBINED TABLET DOSAGE FORM

The present manuscript describes simple, sensitive, rapid, accurate, precise and economical dual wavelength spectrophotometric method for the simultaneous determination of Ambroxol Hydrochloride and Desloratadine Hydrochloride in combined tablet dosage form. The principle for dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional t...

E.A. Sharma* and N. J. Shah

Pharmaceutical Chemistry Department, Indubhai Patel College of Pharmacy and Research Centre, Dharmaj, Petlad- Khambhat Road, Anand, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2584-89

2584-2589

1570

530

30.

VALIDATION OF ABACAVIR SULFATE IN PHARMACEUTICAL DOSAGE BY REVERSE PHASE HPLC WITH INTERNAL STANDARD METHOD

A rapid, specific and accurate isocratic HPLC method was developed and validated for the assay of abacavir sulfate in pharmaceutical dosage forms. The assay involved an isocratic – elution of abacavir sulfate in Grace C18 column using mobile phase composition consists of (38:62 v/v) of methanol and 10ml of potassium dihydrogen orthophosphate. The wavelength of detection is 255nm.The method showe...

B. Venkata Kiran, Battula Sreenivasa Rao* and Som Shankar Dubey

Department of Chemistry, GITAM Institute of Technology, GITAM University, Visakhapatnam- 530 045, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2590-98

2590-2598

1767

445

31.

MICROSCOPICAL AND PHYSICO-CHEMICAL INVESTIGATIONS OF THE LEAVES OF PUTRANJIVA ROXBURGHII WALL.

World Health Organization (WHO, Geneva) has appreciated the importance of medicinal plants for public health care for use in developing nations. Putranjiva roxburghii Wall. is having important role in the traditional Ayurvedic and Unani systems of holistic health and herbal medicine of the East. The leaves of Putranjiva roxburghii Wall. are reported to have good medicinal values in traditional sys...

Madhavi R. Badole* and Vidya V. Dighe

Department of Chemistry, Ramnarain Ruia College, Matunga (East), Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2599-02

2599-2602

1986

789

32.

FACTORS RELATED TO SEVERE ACUTE ASTHMA ATTACK AND TREATMENT

Asthma is a major public health burden that affects a large number of individuals. The prevalence of this chronic disease is very high in Bangladesh. This study is intended to understand the causes of disease and factors that contribute to its progression and to develop improved treatment strategies. The study population included severe acute attack of asthma patients admitted to National Institut...

Kohinur Begum*, Sanjida Haque , Tarikul Islam , Jeb-Un Nesa , Zakir Hossain Sarker and Khadiza Begum

Department of Pharmacy, Bangladesh University, Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2603-06

2603-2606

1553

458

33.

EVALUATION OF EXTRACTION TECHNIQUES WITH VARIOUS SOLVENTS TO DETERMINE EXTRACTION EFFICIENCY OF SELECTED MEDICINAL PLANTS

Herbal drugs play an important role in health care dynamics especially in developing countries. The key step in isolation of biologically active compounds is extraction, which is expressed as total extractive yield, yields of metabolites of interest or intensity of biological activity. Extraction of phytoconstituents from plant materials has been of tremendous interest and potential. Extractive va...

A. G. Patil*, S.P. Koli , D.A. Patil and A.V. Phatak

Associate Professor, Department of Botany-Herbal Sciences, Birla College, Kalyan - 421 304, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2607-12

2607-2612

3086

749

34.

SYNTHESIS OF NEW TWO DERIVATIVES OF 6-MERCAPTOPURINE (6MP) 6-[5-PYRIDINE-4-YL- 1, 2, 3, 4-OXADIAZOLE-2-YL)DITHIOL]-9H-PURINE (38) AND 9H-PURINE-6-YL-BENYLDITHIOCARBAMATE (45) WITH CYTOTOXICITY RESULTS FROM THE NATIONAL CANCER INSTITUTE’S ANTICANCER DRUG SCREEN

6-[(5-pyridine-yl-1, 2, 3, 4-oxadiazole-2-yl)dithiol]-9H-purine (38) and 9H-purine-6yl-benzyldithiocarbamate (45) are synthesized as possible prodrugs for 6-mercaptopurine(6-MP). The generation of the compounds 38, 42, 45 and 48 were accomplished following multistep reaction procedures. The reaction and purity of the products were checked by TLC, the structure of the final compounds and their inte...

Mohammed Hassan Mohammed* and Mohammed Abbas Taher

Assistant Professor, Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2613-22

2613-2622

1762

611

35.

TOXICITY ASSESSMENT OF CLARITHROMYCIN IN DIABETIC WISTAR RATS TREATED WITH ROSIGLITAZONE

Diabetes is a debilitating metabolic disorder characterized by chronically elevated blood glucose level above the normal range and affects mostly all kind of populations epidemiologically. Objectives: In clinical situations, diabetic patients already on prescription of Rosiglitazone are prone to bacterial infection. To cure such infection Clarithromycin is prescribed particularly in Respiratory...

N. M. Meghani*, K. Barve, S. Wackchaure , M.B.Nandanwar , S. Latad and H. Mankani

School of Pharmacy and Technology Management (SPTM), NMIMS, Mumbai-400056, Vile Parle (W), Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2623-32

2623-2632

1499

382

36.

PREVALENCE OF THE METABOLIC SYNDROME IN DIABETIC PATIENTS LIVING IN A COASTAL REGION OF BANGLADESH

Metabolic syndrome (MetS) is a clustering of metabolic abnormalities that has close association with cardiovascular mortality. MetS has becoming a major challenge for public health. To get insight knowledge about the MetS in diabetes, this population-based study was designed. Here we assessed the MetS in diabetes from a coastal region of Bangladesh. MetS was estimated by using the modified definit...

Mohammad Salim Hossain*, Md. Zahedur Rahaman , Sujan Banik , Md. Shahid Sarwar , Kazushige Yokota

Professor, Department of Life Science and Biotechnology, Shimane University 1, 1060 Nishikawatsu-cho, Matsue, Shimane 690-8504, Japan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2633-38

2633-2638

1555

410

37.

IN-VITRO EVALUATION OF ANTIBACTERIAL ACTIVITY AND CYTOTOXICITY EFFECT OF CHEMICALLY SYNTHESIZED ZnO NANOPARTICLE

Nanoparticles, generally considered as particle with a size of upto 100nm, exhibit completely new or improved properties as compared to the larger particles of the bulk material that they are composed of based on specific characteristics such as size, distribution and morphology. In this study ZnO nanoparticle was synthesized by a simple and easy chemical method from ZnCl2. The synthesized nanopar...

K. Renugadevi*, P. Raji and M. Bavanilatha

Department of Biotechnology, Sathyabama University, Rajiv Gandhi Salai, Chennai- 600 119, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2639-43

2639-2643

1315

523

38.

THE EFFECT OF ASPIRIN ON REPRODUCTIVE ORGANS OF FEMALE ALBINO RAT

The aim of present investigation is to study the effect of oral administration of drug acetylsalicylic acid (ASA, aspirin) on female albino rat, Rattus norvegicus. The female rats (n=24) were allocated into 2 groups as control (n=12) and treated (n=12). The treated rats were given oral dose of aspirin 100 mg/ kg body weight for 15 days (n=6) and 30 days (n=6). Tissues enzymological estimations suc...

Neha Jain, Renu Shrivastava, Arun K. Raghuwanshi and Vinoy K. Shrivastava*

Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal- 462026, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2644-47

2644-2647

1994

552

39.

APPLICATION OF ELECTRON DENSITY AND MOLAR VOLUME AS DESCRIPTORS IN QSAR STUDY OF THE ANTIOXIDANT ACTIVITY OF FLAVONOIDS

QSAR study of lipid peroxidation (LPO) inhibitory activity of 18 flavonoids belonging to four classes namely flavones, isoflavones, flavonols and flavanones has been made with the help of PM3 calculations and geometry optimizations using CAChe software. Quantum-chemical descriptors were calculated by the same software using MOPAC 2002 engine. Two quantum-chemical descriptors, molar volume (M.V.) a...

Anil K. Srivastava*, Ratna Gupta , Rajneesh Srivastava and Dinesh K. Mishra

Department of Chemistry, M.L.K. (P.G.) College, Balrampur, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2648-54

2648-2654

1288

462

40.

CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACTS OF JUSTICA ADHATODA

The aim of the study is to observe the cytotoxic activitiy of methanolic crude extracts of root  of Justica adhatoda a plant belonging to the family Acanthaceae. The root of Justica adhatoda was extracted with organic solvent and the extracts were used for the observation of  cytotoxic activitiy.  Crude extracts (n-hexane, ethyl acetate and chloroform soluble fraction)  of Justica adhatoda, we...

Mumita Meskat and Mohammad Musarraf Hussain*

Assistant Professor, Department of Pharmacy Jagannath University, Dhaka-1100, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2655-57

2655-2657

1134

535

41.

SIMULTANEOUS & STABILITY INDICATING METHOD FOR DETERMINATION OF CETRIZINE HYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE IN SYRUP

A simple isocratic HPLC method has been developed and validated as per ICH Guidelines for simultaneous and stability indicating determination of Cetirizine Hydrochloride and Ambroxol hydrochloride in pharmaceutical liquid oral dosage form syrup. Separation was achieved in Hypersil BDS C18 column, 5 μ, and 250 mm x 4.60 mm id with flow rate of 1.5 ml/minute and the detection at 230nm. 0.2 molar Am...

M. Gnana Raja *, G. Geetha , A. Sankaranarayanan , Karna Maga Ganiga Raju and P. Saravanamuthu Kumar

Manager, Analytical research and development, KMS Health Center, Padi, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2658-63

2658-2663

2116

926

42.

EVALUATION OF ETHANOLIC LEAF EXTRACT OF CEIBA PENTANDRA FOR ANTI-OBESITY AND HYPOLIPIDAEMIC ACTIVITY IN CAFETERIA DIET (CD) TREATED WISTAR ALBINO RATS

Ceiba pentandra (C. pentandra) has been traditionally used in the ayurveda system of medicine for the treatment of obesity and atherosclerosis. The present study was undertaken to evaluate anti-obesity and hypolipidaemic activity of the ethanolic leaf extract of C. pentandra in Cafeteria diet (CD) treatedWistar albino rats. Obesity was induced in Wistar albino rats by feeding CD daily for twelve w...

Amol Patil, P. A. Thakurdesai, Shrikant Pawar* and Kedar Soni

Department of Pharmacology, STE’S Smt. Kashibai Navale College of Pharmacy, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2664-68

2664-2668

1878

967

43.

SERUM URIC ACID AS MARKER FOR DIAGNOSING PREECLAMPSIA

Hypertensive disorders are important causes of premature delivery, IUGR and intra uterine fetal death. It accounts for 15% to 20% of maternal deaths in developing as well as developed nations. An association of serum uric acid with hypertensive disorders of pregnancy. The main objective of the present study was measuring and evaluating serum uric acid values in normal pregnant and preeclamptic and...

Satya Prakash , Neha Sharma*, Puja Kumari , Ajit Kumar

Department of Biochemistry, Shri Ram Murti Smarak Institute of Medical Sciences (SRMSIMS), Bareilly, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2669-75

2669-2675

1750

524

44.

PHYSICOTECHNICAL PROPERTIES OF PARACETAMOL TABLETS FORMULATED WITH THE GUM FROM THE FRESH LEAVES OF CORCHORUS OLITORIUS

Corchorus olitorius L. belongs to the family Tiliaceae. It is a plant with diverse medicinal uses. Its leaves when used to cook, give rise to a ‘slimy, viscous’ soup, hence the interest in investigating its binding properties. Gum was extracted from its leaves using standard procedures. The extracted gum was then used to prepare paracetamol tablets using concentrations of 1%, 2%, 4% and 6% res...

U.E. Osonwa, E.M. Uronnachi*, C.E. Umeyor and C.C. Onwuzuligbo

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2676-79

2676-2679

2548

517

45.

ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF SEMECARPUS ANACARDIUM (LINN.) STEM BARKS IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS

The present study was designed to evaluate antidiabetic effects of ethanolic extract of Semecarpus anacardium (SA) stem barks in normal and alloxan induced diabetes rats. The antidiabetic effect of extract was evaluated investigated by measuring fasting blood glucose level and oral glucose tolerance test (OGTT) in normal and alloxan induced diabetes animal models. Here metformin (150 mg/kg) was us...

M. A. Ali*, M. C. Sultana , B. M. Rahman , N. A. Khatune and M.I.I. Wahed

Lecturer, Department of Pharmacy, Bangladesh University, 15/1 Iqbal Road, Mohammadpur, Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2680-85

2680-2685

1651

440

46.

PHYTOCHEMICAL ANALYSIS AND ANTIFUNGAL POTENTIAL OF DURANTA ERECTA AGAINST SOME PHYTOPATOGENIC FUNGI

The present study describes the antifungal activity of Durenta erecta L. against some phytopathogenic fungi: Aspergillus niger, A. flavus, A. fumigatus and Penicillium sp. For this purpose, methhanolic extract of leaf, stem and root were prepared and tested by “Disc Diffusion Method”. The methanol extract was subjected to preliminary phytochemical analysis. Alkaloids, saponins, and polyphenols...

P. Sharma*, S. Khandelwal, T. Singh and R. Vijayvergia

Plant Pathology and Biochemistry Laboratory, Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2686-89

2686-2689

2538

674

47.

COLON TARGETED MATRIX TABLET OF BIODEGRADABLE SWELLABLE POLYMERS

The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small inte...

Kalpen N. Patel*, Maulika S. Patel, Priya D. Patel, Ritesh Prajapati

Shree Krishna Institute of Pharmacy, Shankhalpur, Mehsana, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2690-94

2690-2694

1426

512

48.

STANDARDIZATION OF WHOLE PLANT OF CELOSIA ARGENTEA LINN.

Celosia argentea is a medicinal herb belonging to the family Amaranthaceae has been used traditionally in Ayurveda for the treatment of diarrhoea and dysentery. Extensive studies have been carried out to substantiate its various claimed pharmacologic activities. Present communication records the Pharmacognostic evaluation like Macroscopic and Microscopic characters and Physiochemical evaluation li...

Harjinder Verma* and Manita Demla

R. K. S. D. College of Pharmacy, Kaithal, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2695-99

2695-2699

1568

554

49.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CINNARIZINE AND DOMPERIDONE MALEATE IN PURE AND TABLET DOSAGE FORM

The method for the simultaneous estimation of Cinnarizine and Domperidone maleate from tablet dosage form has been developed, based on simultaneous equation method at two selected wavelength 254nm and 284nm respectively, and also absorbance ratio method at two selected wavelengths 274.0nm (Iso-absorptive point) and 254.0nm (λmax of cinnarizine). The linearity was obtained in the concentration ran...

K.N. Tarkase*, M.K. Tarkase, M.D. Dokhe and V.S. Wagh

Department Of Quality Assurance Technique, Padmashree Dr. Vithalrao Vikhe Patil Foundations, College of Pharmacy, Viladghat, Ahmednagar- 414111, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2700-04

2700-2704

1581

801

50.

DEVELOPMENT AND VALIDATION OF THE HPLC METHOD FOR THE ANALYSIS OF DOXAZOSIN IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS

A simple, economic, selective, precise, and accurate High Performance liquid Chromatographic method for the analysis of Doxazosin in bulk drug and pharmaceutical formulations was developed and validated in the present study. The mobile phase consists of a mixture of Methanol and Potassium Dihydrogen Orthophosphate in the proportion 60: 40. And adjust the pH to 5.0 ± 0.05 with sodium hydroxide sol...

N.V.S. Naidu*, M. Rama Mohan Reddy and P. Suguna

Department of Chemistry, S.V. University, Tirupati-517502, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2705-11

2705-2711

1635

487

51.

PRELIMINARY PHYTOCHEMICAL AND ANTIBACTERIAL SCREENING ON EXTRACTS OF THE AERIAL PARTS OF GALIUM SPURIUM (SUBSPECIES- AFRICANUM)

The common usage of Galium spp. in the Ethiopian traditional medicine, as described in few documentations, are generally related to diseases associated with the nervous system, the immune system, infections and inflammation. Preliminary phytochemical and antimicrobial screening on extracts of the aerial parts of Galium spurium (subspecies africanum) was done in order to partly rationalize some of ...

Mebrahtom Gebrelibanos*, Ciddi Veeresham and Kaleab Asres

Course & Research Unit of Pharmacognosy, Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2712-15

2712-2715

1206

531

52.

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF CIPROFLOXACIN AND ORNIDAZOLE IN TABLET DOSAGE FORM

Three simple sensitive, rapid, accurate and economical methods were developed for simultaneous estimation of Ciprofloxacin & Ornidazole in bulk and its pharmaceutical formulations. First method was based on the simultaneous equation, second method was based on Q-Analysis (Absorbance ratio method) and third method was based on multicomponent mode. The absorption maxima for Ciprofloxacin and Orn...

A.S. Grewal*, S.K. Patro , S.K. Kanungo and S.K. Bhardwaj

Assistant Professor, JCDM College of Pharmacy, Sirsa- 125 055, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2716-20

2716-2720

2173

787

53.

ETHNOBOTANY AND PHYTOCHEMICAL ANALYSIS OF PYRUS PASHIA LEAVES

Pyrus pashia Buch.-Ham. ex D. Don is distributed in the Himalayan region with great ethnic uses. Leaves of P. pashia are consumed as butter tea beverages by the Monpa community of Tawang, Arunachal Pradesh (India). The pulverized leaves were extracted using accelerated solvent extractor (ASE) in different organic solvents with increasing polarity. The leaf extracts of P. pashia were evaluated for ...

Jambey Tsering*, Baikuntha Jyoti Gogoi and Hui Tag

Project Fellow and Ph.D. Scholar, Department of Botany, Rajiv Gandhi University, Rono Hills, Doimukh- 791 112, Arunachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2721-25

2721-2725

1632

640

54.

ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC EFFECTS OF STEPHANIA JAPONICA (THUNB.) MIERS. TENRIL IN ALLOXAN INDUCED DIABETIC MICE

The present study was carried out to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and antihyperlipidemic (Total cholesterol and triglycerides) effects of the methanolic extract of Stephania japonica (Thunb.) Miers. tenril (MSJT). The MSJT was administered orally as a dose of 250 and 500 mg/kg body weight to alloxan induced hyperglycemic rats and found to reduce blood gluco...

M. Chand Sultana , M. Badrul Alam*, M. Asadujjaman and M. Ahsan Akter

Lecturer, Department of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2726-32

2726-2732

1395

347

55.

FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE BILAYERED BUCCAL TABLETS OF ROSUVASTATIN CALCIUM

The purpose of this research work was to establish mucoadhesive buccal device of Rosuvastatin Calcium(RC) in the form of bilayered tablet. The tablets were prepared using natural gums like Xanthan gum, Tamarid gum, Gellan gum and Chitosan as bioadhesive polymers to impart mucoadhesion as well as permeation enhancement property to the formulation. Ethyl cellulose & magnesium stearate were added...

Amish V. Panchal*, Markand Mehta, Viral H. Shah, Umesh Upadhyay

Department of Pharmaceutics, Sigma institute of Pharmacy, Baroda, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2733-40

2733-2740

1877

1302

56.

DESIGN, DEVELOPMENT AND OPTIMIZATION OF VALSARTAN LIQUISOLID TABLETS USING BOX-BEHNKEN DESIGN

The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties of  Valsartan in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: amount of liquid vehicle (X1), ratio of carrier to coating material(X2) and amount of magnesium oxide(X3) on angle of repose (Y1), har...

C.V. Shah*, H.K. Patel, V.H. Shah and U.M. Upadhyay

Deparrment of Pharmaceutics, Sigma institute of Pharmacy, Baroda, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2741-53

2741-2753

1651

612

57.

ANTI-INFLAMMATORY AND ANTIBACTERIAL STUDIES ON INDIGOFERA LINIFOLIA RETZ.

Indigofera linifolia Retz(Fabaceae) is herb which spread throughout the India and found to be used by the tribal to cure inflammations. Based upon the review the present study focused on screening of Ant-inflammatory and Anti-bacterial activity of Indigofera linifolia Retz. The coarse powder of whole plant was extracted by cold maceration method using various solvents successively. Preliminary phy...

M. Uvarani*, R. Arun Pandian, B. Jenila, R. Sutharsingh and A. Thangathirupathi

Department of Pharmacognosy, Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi-626130, Tamilnadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2754-56

2754-2756

1169

660

58.

DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING ASSAY METHOD OF PYRIMETHAINE BY USING DIFFERENT STRESS DEGRADATION CONDITIONS

The aim of the present work is to develop simple accurate, precise and cost effective UV-Vis spectrophotometric method for the estimation of pyrimethamine in bulk and pharmaceutical dosage form and determination of percent degradation by using different stress condition. The solvent used was methanol and distilled water (40:60) and λmax of the drug was found to be 272.5nm. A linear response was o...

N.B. Tembhurkar*, V.V. Chopade, S.B. Jadhav and P.D. Chaudhari

Department of Pharmaceutical Chemistry, Modern College of Pharmacy Nigdi, Pune-411044 Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2763-68

2763-2768

1309

628

59.

EVALUATION OF N-(6-CHLOROBENZOTHIAZOL-2-YL)-2-(SUBSTITUTEDAMINO)ACETAMIDE FOR ITS ANTI-BACTERIAL ACTIVITY

In the present study, a series of some novel benzothaizole derivatives (BZT 1-10) were screened for their antibacterial activity against S. typhi, S. dysenterae, E. coli, S.aureus and B. subtlis employing Disc Diffusion method and taking Agar as culture media. Streptomycin (25µg/ml) was used as a standard drug. The solvent, DMSO used for the preparation of compounds did not show inhibition agains...

Pranav Prabhat*, Sreemoy Kanti Das, Kausar Shafaat and J.P. Anand

Faculty of Pharmacy, S. Sinha College, Aurangabad- 824 102, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2769-74

2669-2674

1196

490

60.

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF SALBUTAMOL SULPHATE

Objective of the present work is to develop orodispersible tablets of Salbutamol sulphate to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Orodispersible tablets are the fast growing and highly accepted drug delivery system in now days mainly to improve patient compliance. Orodispersible tablets have number of advantages over conventional dosage forms, ...

D.K. Gupta*, R.D. Sharma, Ritu Gupta , S. Tyagi , K.K. Sharma and Anurag Choudhary

Assistant Professor, Department of Pharmacy, Faculty of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2775-78

2675-2678

1688

469

61.

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND DETERMINATION OF TOTAL FLAVONOIDS AND TANNIN CONTENTS OF LAGENARIA SICERARIA ROOT

The crude ethanolic extract of the root of Lagenaria siceraria (Molina) Standley (Family: Cucurbitaceae), was evaluated for its possible anti-inflammatory activity and determination of total flavonoids and tannin contents growing in Bangladesh. The anti-inflammatory activity was studied using carrageenan and histamine-induced rat paw edema test at different doses (200 and 400 mg/kg body weight) of...

Hemayet Hossain*, A.F.M Shahid-Ud-Daula, Ismet Ara Jahan, Ishrat Nimmi, K. M. Rahat Maruf and Md. Musfizur Hassan

Senior Scientific Officer, Chemical Research Division, BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka-1205, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2779-85

2679-2685

1381

426

62.

PREPARATION AND EVALUATION OF TIMOLOL MALEATE MATRIX TABLET USING HYDROGEL FORMING POLYSACCHARIDES

Matrix tablets of timolol maleate were prepared using hydrogel forming natural polysaccharides like sodium alginate, xanthan gum and guar gum alone and with hydrophobic polymers like ethyl cellulose and hydroxyethyl cellulose by direct compression method. The Fourier-transform infrared spectroscopy of drug-polymer and polymer-polymer was studied and revealed the compatibility of drug and polymer. ...

M.A. Saleem*, Dhaval Malvania, Jaydeep Patel, Y.D. Murali and Md. Naheed

Luqman College of Pharmacy, Gulbarga-585 102, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2786-94

2786-2794

1822

812

63.

MEDICATION STORAGE AND SELF MEDICATION PRACTICE AMONG THE YOUTH IN KARNATAKA REGION, INDIA

Aim: The aim of the study was to determine the prevalence, approach and behavior towards medication storage & self-medication practice amongst the youth in Karnataka, India. Methodology: A pre-cross sectional survey was conducted, administering a pre-piloted questionnaire among the target population. Sample size of 150 was analyzed using the percentage method. Results: Out of 150 respond...

Abhishek Sharma*, Ankush Madaan and Anantha Naik Nagappa

Professor, Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576 104, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2795-00

2795-2800

2020

471

64.

FORMULATION AND EVALUATION OF FLOATING MICROSPHERE H2 RECEPTOR BLOCKER RANITIDINE HCl BY IONIC GELATION METHOD

The present study involves preparation of floating microspheres of Ranitidine Hydrochloride with Sodium alginate, Guargum and Xanthan using ionic gelation method. Floating microspheres were aimed to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavailability. The formulations were evaluated for FTIR, drug loading, ...

Ajaykumar Tiwari*, Gaurang Patel and Nirav Rabadia

Department of Pharmaceutics, School of Pharmaceutical Science, Jaipur National University, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2801-08

2801-2808

1781

682

65.

SCIENTIFIC VALIDATION OF JAWARISH-E-BISBASA – A UNANI FORMULATION

The compound drug Jawarish-e-Bisbasa is a polyherbal Unani formulation. It is used in the ailments of general weakness of the stomach, flatulence in the stomach, indigestion, blind piles and nausea etc. Therefore the scientific validation for development of SOP, pharmacopoeial standards, TLC studies and safety parameter is very much essential to provide the quality medicine to the needy mass. The ...

Rampratap MeenaD Ramasamy , S Mageswari , Syed Jameeluddin Ahmed , Samsul Arifin, Shamshad Ahmed Khan and Syed Shakir Jameel

Research Officer (Chemistry), Regional Research Institute of Unani Medicine (CCRUM), No. 1, West Madha Church Road, Chennai – 600 013, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2809-14

2809-2814

3559

871

66.

ANTIMICROBIAL ACTIVITY OF JUNIPERUS COMMUNIS AND SOLANUM XANTHOCARPUM

Methanolic extracts of two Indian medicinal plants Juniperus communis and Solanum xanthocarpum, were examined for their antimicrobial potential against selected bacteria and fungi. The purpose of screening is to justify and authenticate the use of Indian medicinal plants in ethno medicinal or folklore as traditional treasure to cure various ailments. In present investigations attempts were made to...

Ekta Menghani* and Sita Kumari Sharma

Department of Biotechnology, Mahatma Gandhi Institute of Applied Sciences, JECRC Campus Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2815-18

2815-2818

1482

501

67.

NATURAL ANTIOXIDANT (FLAVONE GLYCOSIDE) FROM SESBANIA ACULEATA PERS. AND ITS POTENTIAL ACTIVITY

This paper deals with the significance and importance of medicinal plants.New flavone glycoside A, m.p. 222-224oC, m.f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Sesbania aculeata Pers. along with three known compounds Kaempferol 3-O-a-L-rhamnopyranosyl-(1®2)-b-D-glucopyranoside, (B) and Mearnsetin-3-O-a-L-rhamnopyranoside (C)  Gehuain(isoflavone) (D). The compound A was ch...

D.K. Satnami and R.N. Yadava

Natural Products Laboratory, Department of Chemistry, Dr. Hari Singh Gour University, Sagar (M.P.) 470 003, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2819-24

2819-2824

1229

744

68.

EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF PERSICARIA CHINENSIS LEAVES

The scientific basis of medicinal plants often claimed that the valuable ethnobotanical medicinal-related information was true. Hence, researchers always develop deep interest in finding natural resources like medicinal plants to combat infectious diseases instead of using modern pharmaceutical drugs that can lead to vast antibiotic resistance issues. In this present study, various leaf extracts o...

Shu Mei Lai*, D. Sudhahar , K. Anandarajagopal

School of Pharmacy and Applied Science, La Trobe University, Bendigo, Victoria- 3552, Australia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2825-30

2825-2830

1935

1042

69.

FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEX OF ACETYL SALICYLIC ACID (ASPIRIN) AND β- CYCLODEXTRIN BY SOLVENT EVAPORATION & ITS COMPARATIVE STUDY TO ASPIRIN ALONE

The aim of present study was to determine whether pharmaceutical and pharmacological activity of aspirin would enhance in form of inclusion complex with β–cyclodextrin or not.Aspirin (Acetyl salicylic acid) a non steroidal anti-inflammatory drug, was formulated in to inclusion complex with β–cyclodextrin (β–CD) by solvent evaporation. The phase-solubility curve was AL type and Kst was fou...

Dolita K. Shah

Smt. R. B. Patel Mahila Pharmacy College, Atkot-360 040, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2831-36

2831-2836

2646

1064

70.

PHARMACOLOGICAL AND PHYTOCHEMICAL EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF SOLANUM NIGRUM

Anti-ulcer activity of the Solanum nigrum     L. extracts was studied in rats by using pylorus ligated ulcer model. Rantidine was used as the standard drug for comparison. The animals were sacrificed after 19 hrs after the ligation. Stomach was dissected out and contents were drained into tubes and were centrifuged at 1000 rpm for 10min and volume was noted. The PH of gastric juice was recorde...

G.G. Kavitha Shree*, S. Parvathi , P.S.S. Ramkumar , S. Shanmuga Priya

Senior Research Fellow, Department of Home Science Extension, Home Science College and Research Institute, Tamil Nadu Agricultural University, Madurai- 625 104, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2837-40

2837-2840

1362

379

71.

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY OF SOLANUM NIGRUM IN ALLOXAN INDUCED DIABETIC ALBINO RATS

The objective of this study is to induce experimental diabetes mellitus using Alloxan monohydrate in normal adult albino rats and study the anti‐diabetic activity of changes in body weight, consumption of food and water, volume of urine and levels of glucose between normal and diabetic rats. Diabetes mellitus (DM) is a common endocrine disorder. Hypoglycemic agents from natural and synthetic sou...

Arumugam Sengottaiyan*, L. Praburaman , Koildhasan Manoharan , Rathika Rajinikanth , Muthusamy Govarthanan and Thangaswamy Selvankumar

Department of Biotechnology, Mahendra Arts & Science College, Kalipatti- 637501 Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2841-48

2841-2848

2794

618

72.

PROTECTIVE EFFICACY OF THE EXTRACT OF VOLVARIELLA VOLVACEA (BULLIARD EX FRIES) SINGER. AGAINST CARBONTETRACHLORIDE INDUCED HEPATIC INJURY

Carbon tetrachloride is a xenobiotic that produces hepatotoxicity. Aqueous extract Volvariella volvacea (500, 1000 mg/kg, p.o) showed significant hepatoprotective activity against carbontetrachloride induced hepatotoxicity in rats by normalizing the levels of serum AST, ALT, ALP, LDH and total bilirubin. The extract improved the activity of Catalase (CAT), Superoxide dismutase (SOD), and hepatic g...

S.V. Kalava* and S.G. Menon

Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore-641029, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2849-56

2849-2856

1242

414

73.

EVALUATION OF PHYTOCHEMICAL AND ANTIMITOTIC POTENTIAL OF LAGENARIA SICERARIA FRUIT USING ONION ROOT MODEL

Cancer is one of the leading causes of mortality worldwide. Many of the cucurbitaceae plants traditionally reported to possess antitumor activity. The present study was carried out to evaluate the anticancer activity for different extracts of Lagenaria siceraria Fruit. The present research work had carried out on laboratory level assay to avoid the use of different animal models. Preliminary phyto...

S. S. Mahamuni*, S. G. Killedar, H. N. More, A.B. Nale, A. A. Pawar and S. V. Chavan

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur- 416 013, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2857-61

2857-2861

2198

627

74.

PHYTOCHEMICAL AND IN VITRO ANTIOXIDANT POTENTIAL OF AQUEOUS LEAF EXTRACTS OF BRASSICA JUNCEA AND CORIANDRUM SATIVUM

In the present study, Phytochemical and in vitro Antioxidant potential of aqueous leaf extracts of Brassica juncea and Coriandrum sativum leaves was determined qualitatively. The Phytochemical screening of plants studied showed the presence of terpenoids, flavonoids, tannin and reducing sugar in aqueous extract of Brassica juncea. Alkaloids and glycosides were absent in it. Aqueous extract of Cori...

Kanchan , P. K. Chauhan, Munish Jaryal , Kiran Kumari and Manjeet Singh

C/O Chauhan Clinic, Kiln Area, Nangal Township, Distt. Ropar, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2862-65

2862-2865

1737

663

75.

ANTIOXIDANT ACTIVITY OF THE ENDOPHYTIC FUNGI ISOLATED FROM MANGROVE ENVIRONMENT OF KARANKADU, RAMANATHAPURAM DISTRICT

Antioxidant property of Phomopsis amygdali culture filtrate extracted with ethanol, was evaluated in vitro. ABTS and DPPH radicals were used to evaluate their antioxidant  activity. Antioxidant components like total phenol and flavonoid were also determined. The ethanolic extract of Phomopsis amygdali showed potent antioxidant activity against both ABTS and DPPH radicals with the EC50 value of 58...

R. Bharathidasan and A. Panneerselvam

P.G. Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi-613 503, Thanjavur Dist, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2866-69

2866-2869

1498

524

76.

DEVELOPMENT OF QUALITY STANDARDS OF VATARI CHURNA: A POLYHERBAL FORMULATION

India is a landmark for traditional system of medicine from past few centuries. Most of the medicines are effective but only one major drawback is lack of standardization. So, there is a need to develop a standardization technique to mingle this system of medicine in the main stream of health science. Standardization of herbal formulations is essential in order to assess the quality of drugs, base...

V. Sharma, K. Agarwal*, J. Maithani, and D. NandaDev Bhoomi Institute of Pharmacy & Research, Dehradun, Uttarakhand, India

Dev Bhoomi Institute of Pharmacy & Research, Dehradun, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2870-72

2870-2872

1445

388

77.

EVALUATING THE EFFECT OF EXTRACT OF HALELA SIYAH (TERMINALIA CHEBULA RETZ) ON CHEMICALLY INDUCED CATALEPSY IN MICE

The objective of the present study was to evaluate the anticataleptic effect of Halela siyah (Terminalia chebula Retz) extract, on haloperidol induced catalepsy in swiss mice which were divided into four groups of six animals each. Animals in different groups were administered distilled water, scopolamine (1.0 mg/kg p.o) and hydroxy alcoholic (3:7) extract of Halela siyah (Terminalia chebula Retz)...

Pervaiz Ahmad Dar*, G. Sofi and M. A. Jafri

Department of Ilmul Advia, IAMS Zakura, Srinagar, Jammu & Kashmir, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2873-79

2873-2879

2147

369