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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 3 (2012) - Issue 9, September

Review Articles

 
Title
Views
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1.

LIPID BASED PARENTERAL DRUG DELIVERY SYSTEM

Lipid-based drug delivery systems in the form of triglyceride emulsions, micellar systems and liposomes have been used for parenteral administration for the last few decades. Large number of new chemical entities (NCE) presents formulation and bioavailability problems because of the dose and poor solubility in solvent and co-solvent systems. In addition, high drug concentrations can lead to irrita...

Shery Jacob

College of Pharmacy, Gulf Medical University, Ajman, UAE

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2880-87

2880-2887

2483

749

2.

CURRENT ADVANCES IN SUSTAINED-RELEASE INJECTABLE PREPARATIONS

In recent years, there has been a great deal of interests in developing sustained-release systems which can prolong the therapeutic effect, decrease adverse side effects, and reduce administration frequency. Nowadays, the oral sustained-release preparations account for a larger market share comparing to other sustained-release forms, mainly because of its noninvasive pain-free administration. Howe...

Liandong Hu*, Hailei Zhang, and Weihua Song

Key Laboratory of Pharmaceutical Quality Control of Hebei Province & School of Pharmaceutical Sciences, Hebei University, Baoding, 071002, PR China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2888-96

2888-2896

2570

821

3.

TRANSDERMAL PATCHES: A SYNERGISTIC APPROACH OF DRUG DELIVERY FOR NSAIDs

Transdermal drug delivery system has been accepted as potential non-invasive route of drug administration, with advantages of prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs (NSAIDs) represents the most commonly used medications for the treatment of pain and inflammat...

Pragya* and V. Rastogi

Department of Pharmacy, IFTM University, Lodhipur Rajput, Delhi Road (NH-24), Moradabad-244102, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2897-09

2897-2909

3008

1765

4.

MITOCHONDRIA: INSIGHT TARGET OF DRUG DEVELOPMENT IN CANCER CELLS

Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival and its dysfunction leads to many human abnormalities, including cardiovascular diseases, neurodegenerative diseases, autoimmune disorders and cancer. The present review is focused on the different experimental and therapeutic cancer strategies addressed t...

Md. Ataur Rahman

Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chuncheon, Gangwon-do, 200-702, South Korea

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2910-18

2910-2918

1478

631

5.

MOUTH DISSOLVING TABLETS: AN OVERVIEW

The gold standard in pharmaceutical industry is the oral delivery because it is the easiest, safest, economical and convenient method for the drug delivery. Mouth dissolving tablets have becomes the most demanding application during last decades and in the pharmaceutical industry this field has become a rapidly area. Mouth dissolving tablets during insertion in the mouth should have to dissolve or...

Gagandeep Chawla* and Nitin Jain

School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2919-25

2919-2925

3554

938

6.

MICROSPONGES AS THE VERSATILE TOOL FOR TOPICAL ROUTE: A REVIEW

The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Conventional topical formulations are intended to work on the surface of the skin. Normally, upon application such formulations release their active ingredients and producing a ...

Archana Patel*, Pratik Upadhyay, Jatin Trivedi, Shreeraj Shah and Jaymin Patel

L. J. Institute of Pharmacy, Near Nagdev Kalyan Mandir, S.G. Road, Ahmedabad- 382210, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2926-37

2926-2937

2539

839

7.

A NOVEL OPHTHALMIC DRUG DELIVERY SYSTEM: IN-SITU GEL

The ophthalmic in-situ gels now days proved an palpable sustained drug delivery in various eye diseases. The formulation of in-situ gels for eye which carries the advantages like easy for administration, reduces frequency of dose and improves patient compliance. The formation of in-situ gels depends on phase transition system or sol-gel transition system. The formulation approaches like temperatur...

A.P. Patil*, A.A. Tagalpallewar, G.M. Rasve, A.V. Bendre, P.G. Khapekar

Sinhgad Institute of Pharmacy, Narhe, Pune - 411 041, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2938-46

2938-2946

3880

642

8.

IMPORTANCE OF HETEROCYCLIC CHEMISTRY: A REVIEW

Heterocyclic compounds are of very much interest in our daily life. Heterocyclic compounds have one or more hetero atoms in their structure. They may be cyclic or non cyclic in nature. Heterocyclic compunds  have a wide range of application. They are predominantly used as pharmaceuticals, as agrochemicals and as veterinary products. They also find applications as sanitizers, developers, antioxida...

Pragi Arora*, Varun Arora , H.S. Lamba and Deepak Wadhwa

R.K.S.D. College of Pharmacy, Kaithal, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2947-54

2947-2954

46630

6098

9.

AN UPDATED REVIEW ON MOLECULAR GENETICS, PHYTOCHEMISTRY, PHARMACOLOGY AND PHYSIOLOGY OF BLACK NIGHTSHADE (SOLANUM NIGRUM)

This article reviews, connected the gap between the folkloric use of Solanum nigrum and the results of evidence based experiments. Although Solanum nigrum is a rich source of one of plants most dreaded toxins solanine, it has appreciably monstrated its potential as a reservoir of antioxidants having hepatoprotective, anti-tumor, cytostatic, anti-convulsant, anti-ulcerogenic and anti-inflammatory.e...

Ashwani Kumar*, S. Sagwal, Niketa and S. Rani

Department of Bioscience, Shri Ram College Muzaffarnagar, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2955-77

2955-2977

3360

2502

10.

STABILITY INDICATING HPLC METHOD DEVELOPMENT: A REVIEW

High performance liquid chromatography is one of the most accurate methods widely used for the quantitative as well as qualitative analysis of drug product and is used for determining drug product stability. Stability indicating HPLC methods are used to separate various drug related impurities that are formed during the synthesis or manufacture of drug product. This article discusses the strategie...

Bhoomi P. Shah*, Suresh Jain, Krishna K. Prajapati and Nasimabanu Y. Mansuri

Department of Quality Assurance, Baroda College of Pharmacy, Vadodara, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2978-88

2978-2988

11561

1896

11.

REVIEW ON ADVANCES IN COLON TARGETED DRUG DELIVERY SYSTEM

The colon is the terminal part of the GIT which has gained in recent years as a potential site for delivery of various novel therapeutic drugs, i.e. peptides. However, colon is rich in microflora which can be used to target the drug release in the colon. Colon is a site where both local and systemic drug delivery can take place. Local delivery allows the topical treatment of inflammatory bowel dis...

Sunena Sethi, SL Harikumar* and Nirmala

Rayat & Bahra Institute of Pharmacy, Sahauran, Kharar, Dist. Mohali -140104, Chandigarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2989-00

2989-3000

2368

839

12.

HERBS IN PREGNANCY AND LACTATION: A REVIEW APPRAISAL

Pregnancy can be the most paranormal and exciting time for expectant mother. Nature provides us with many tools for supporting both the mother and baby through this time of growth and renewal, to strengthen the spirits and body to promote a healthy pregnancy and birthing process. Pregnant and lacting mother need to be educated on the need for caution when using herbs during pregnancy and lactation...

Poonam Shinde*, Pankaj Patil and Vinod Bairagi

Department of Pharmacognosy and Phytochemistry, K.B.H.S.S. Trust’s Institute of Pharmacy, Malegaon- 423105, Dist- Nashik, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3001-06

3001-3006

5490

1231

13.

AN OVERVIEW OF PHARMACEUTICAL PROCESS VALIDATION AND PROCESS CONTROL VARIABLES OF TABLETS MANUFACTURING PROCESSES IN INDUSTRY

Validation is an integral part of quality assurance; the product quality is derived from careful attention to a number of factors including selection of quality parts and materials, adequate product and manufacturing process design, control of the process variables, in-process and end-product testing. Recently validation has become one of the pharmaceutical industry’s most recognized and discuss...

Mahesh B. Wazade*, Sheelpriya R. Walde and Abhay M. Ittadwar

Department of Quality Assurance, Gurunanak College of Pharmacy, Nagpur-440 026, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3007-22

3007-3022

11435

4664

14.

GENERIC DRUG USER FEE: AN OVERVIEW

The globalization of generic drug manufacturing, supply and testing, and a growing workload that has far outpaced USFDA’s resources has created new challenges. USFDA & Industry propose generic drug user fee to address the need for globalization of the inspection process, and to speed the timely review of generic product applications. The Generic Drug User Fee (GDUF) proposal is agreed by gen...

Darshit S. Patel*, Abhishek R. Patel and Narendra A. Patel

Astron Research Limited, Ahmedabad, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3023-30

3023-3030

2054

752

15.

LANTANA CAMARA: OVERVIEW ON TOXIC TO POTENT MEDICINAL PROPERTIES

Lantana camara is more popular as toxic weed rather than medicinal plant in most of the countries responsible for infesting pastures, grazing lands, orchards and crops like, tea, coffee, oil palm, coconut and cotton, and reduces the economic viability of the crops. This plant can grow even in extreme harsh climatic conditions of tropical and sub-tropical areas and has become naturalized worldwide ...

M.K. Lonare, M. Sharma , S.W. Hajare and V.I. Borekar

Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Post Graduate Institute of Veterinary and Animal Sciences, Krishnagar, Murtizapur Road, Akola- 444 104, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3031-35

3031-3035

11172

1115

16.

BIOMARKERS FOR THERAPEUTIC RESPONSE IN CERVICAL CANCER

Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Despite the tremendous progress that has been achieved in the screening and management of cervical cancer, there is still a need for clinically relevant prognostic biomarkers to monitor the response of patients to various therapies and to predict the chances of recurrence and recovery....

Saleena Ummer V* and Asha Das

Department of MLT, Manipal College of Allied health Sciences, Manipal University, Manipal- 576 104 Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3036-44

3036-3044

1821

510

17.

ANGIOGENESIS IN CARDIOVASCULAR DISEASE: A REVIEW

Angiogenesis is process of new blood vessel formation that occurs under both normal and pathological conditions. In the normal state, two distinct processes can be seen. One utilizes endothelial progenitor cells (EPC) and the second utilizes existing vasculature to generate new vessels. The healthy body controls angiogenesis through a series of "on" (angiogenesis-stimulating growth factors) and "o...

H. Modi* M. Shrimanker , K Patel , V. Patel and S. Bhadani

Saraswati Institute of Pharmaceutical Sciences, Chiloda, Gandhinagar – 382355, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3045-57

3045-3057

1682

466

18.

THE CONCEPT OF MICROBUBBLE AS A DRUG DELIVERY SYSTEM: AN OVERVIEW

Micro bubbles are small spherical type of bubble which consists of a gas, they are separated from each other, so they cannot agglomerates. Actually, they have size range in micrometers usually  1-100 micrometer. They are capable of penetrating even into the smallest blood capillaries & releasing drugs or genes, incorporated on their surface, under the action of ultrasound. Microbubbles in gen...

Hitesh B. Katariya

Department of Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charusat, Changa, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3058-63

3058-3063

1735

513

19.

IN VITRO ANTIHELMINTIC ACTIVITY OF SOME MEDICINAL PLANTS: A REVIEW

Helminthiasis is infestation with one or more intestinal parasitic worms roundworms, whipworms , or hookworms in humans and animals. Presently, many synthetic drugs are available to treat Helminthiasis infection effectively, but suffer from number of side effects like abdominal pain, dizziness, headache, fever, nausea, vomiting, or temporary hair loss. Moreover, drug resistance is also another fac...

Manish H. Bachani

K.B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3064-75

3064-3075

1879

905

20.

MICROBIAL L-ASPARAGINASE: A REVIEW ON CURRENT SCENARIO AND FUTURE PROSPECTS

L-Asparaginase (E.C. 3.5.1.1.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma. This article has briefly touched nearly all the industrial and clinical aspects of L-Asparaginase and provides the recent update of the topic. The article includes a brief introd...

S. Kumar Jha*, Divya Pasrija, Rati Kumari Sinha, Hare Ram Singh, Vinod Kumar Nigam and Ambrish Sharan Vidyarthi

Department of Biotechnology, BIT Mesra, Ranchi, Jharkhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3076-90

3076-3090

4550

1271

21.

CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW, PART II. CRINUM ALKALOIDS: CRININE-TYPE ALKALOIDS

Crinum is a genus of about 130 species belonging to family Amaryllidaceae with wide geographical distribution throughout the tropics, subtropics and warm temperate regions of the world. These plants are not only showy ornamentals but they possess significant folkloric and commercial reputation as well. Long ago, Crinums have been subjected to extensive chemical, cytological and pharmacological inv...

John Refaat *, Mohamed S. Kamel , Mahmoud A. Ramadan and Ahmed A. Ali

Pharmacognosy Department, Faculty of Pharmacy, Minia University 1, Minia-61519, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3091-00

3091-3100

2345

969

Research Articles

 
Title
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Cited
22.

THE IN-VIVO EFFECTS OF PARTIALLY PURIFIED SUB-FRACTION (TAF2) OF THE CRUDE METHANOLIC EXTRACT OF EURYCOMA LONGIFOLIA ROOTS ON THE HAEMATOLOGICAL, BIOCHEMICAL AND HISTOLOGY PARAMETERS

Eurycoma longifolia (E. longifolia) Jack has been widely used in traditional medicine for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial, anti-pyretic and anticancer activities. As yet, no study has been done on biosafety of partially purified sub-fraction (TAF2) of the crude methanolic extract of E. longifolia roots. This study aims to evaluate, in vivo, the effects of TAF2 on the ha...

Omar Saeed Ali Al-Salahi , Abdel-Hamid Zaki ,Kit-Lam Chan , Amin Malik Shah , Wan Zaidah Abdullah , Narazah Mohd Yusoff*

MBBS (Malaya), DCP (London), M Med Sc (London), PhD (Kobe), Associate Professor and Hematologist, Advanced Medical and Dental Institutem, Universiti Sains Malaysia, No 6 (Lot 13), Persiaran Seksyen 4/9, Bandar Putra Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3101-05

3101-3105

1418

516

24.

ROSIN MICROSPHERES AS TASTE MASKING AGENT IN ORAL DRUG DELIVERY SYSTEM

Natural resources in general and plant materials in particular are receiving more attention due to their safety as pharmaceutical excipients. Present work assessed the combination potential of natural hydrophobic resin, rosin, and synthetic polymer ethyl cellulose to mask the abhorrent inherent taste of ambroxol hydrochloride, by microencapsulation technique, and its possibility to formulate as a ...

Shery Jacob

Department of Pharmaceutics, College of Pharmacy, Gulf Medical University, Ajman, UAE

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3116-24

3116-3124

1923

721

25.

ROLE OF BISOPROLOL ADDING TO ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR AND FUROSEMIDE COMBINATION ON THE LEFT VENTRICULAR FUNCTION IN SYSTOLIC HEART FAILURE PATIENTS

Background: β-blocker is an established therapeutic strategy for stage C systolic heart failure based on the American Heart Association guideline, nonetheless limited studies analyzed the role of β-blocker primarily Bisoprolol adding to ACE inhibitor and furosemide combination on the left ventricular function in systolic heart failure patients. Objectives: This study was designed to analyze t...

Efta Triastuti*; Dadang Hendrawan and Muhammad Saifurrohman

Study Program of Pharmacy, Faculty of Medicine, Brawijaya University 1, Malang, Indonesia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3125-30

3125-3130

1374

591

26.

AN EVALUATION OF ACUTE AND SUBCHRONIC TOXICITIES OF A NIGERIAN POLYHERBAL ANTIDIABETIC REMEDY

The acute and subchronic toxicities of Nigerian polyherbal antidiabetic remedy, prepared from Gongrenema latifolium and Allium cepa (1:1) leaves was investigated in Swiss albino mice and rats of both sexes. For acute toxicity study, 1000-5000mg/kg of the combined extract were administered orally to rats and observed for 24 hours for obvious toxic symptoms and mortality. The median lethal dose of t...

H.I. Obi, E.E. Ilodigwe , D.L. Ajaghaku*, J.M. Okonta

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Agulu Campus, Anambra state, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3131-35

3131-3135

1416

560

27.

PRELIMINARY TOXICITY STUDY, ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY PROPERTIES OF EXTRACTS FROM SIDA RHOMBIFOLIA L. (MALVACEAE)

Background: Sida rhombifolia L. (Malvaceae) is in flora of Asian medicinal herbs and used traditionally in West of Burkina Faso for the treatment of inflammatory diseases, fever, pain and possesses analgesic properties. The aim of the study was to access the biological activities of extract (acetone/water extract) and alkaloid extracts from Sida rhombifolia L. (Malvaceae) in the carrageenan-induce...

Kiessoun Konate, Jacques Francois Mavoungou , Maurice Ouédraogo , Alexis Nicaise Lepengue , Alain Souza, Nicolas Barro and Bertrand M’Batchi

Laboratory of Animal Physiology, Electrophysiology and Pharmacology, Faculty of Sciences, University of Science and Technology of Line Masuku, Gabon, Franceville

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3136-45

3136-3145

1537

578

28.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND INDAPAMIDE IN TABLET DOSAGE FORM

A simple, specific, accurate and precise reversed phase high pressure liquid chromatographic method has been developed for the simultaneous determination of Amlodipine Besyltate and Indapamide in tablet dosage form by reversed phase C18 column (Phenomenex C18, 5μ, 250 mm x 4.6 mm). The sample was analysed using Methanol: Water in the ratio of 95:5 as a mobile phase at a flow rate of 1.0 ml/min an...

Manish C. Raj* and Bharat G. Chaudhari

Department of Quality Assurance, Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3146-50

3146-3150

2140

664

29.

A VALIDATED LC METHOD FOR THE DETERMINATION OF CHIRAL PURITY OF (R)-3-((1-METHYLPYRROLIDIN-2-YL) METHYL)-5-(METHYLSULFONYLMETHYL)-1H-INDOLE: A KEY RAW MATERIAL OF ELITRIPTAN HYDROBROMIDE

A simple and accurate normal phase liquid chromatographic method was developed for the determination of chiral purity of (R)-3-((1-methylpyrrolidin-2-yl) methyl)-5-(methylsulfonylmethyl)-1H-indole, R-isomer used as key starting raw material in the manufacturing of Elitriptan hydrobromide bulk drug. Chromatographic separation between (R)-3-((1-methylpyrrolidin-2-yl) methyl)-5-(methylsulfonylmethyl)...

M. Sarat, P. Murali Krishna and C. Rambabu*

Acharya Nagarjuna University, Nagarjuna Nagar-522510, Guntur dist, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3151-55

3151-3155

1335

625

30.

IMPACT OF TRADE AND TRIPS ON AFFORDABILITY OF MEDICINE IN TANZANIA

To meet healthcare demands and costs, Tanzania depends largely on imports and financial aid from foreign countries. Current research analyses the impact of market competition on the cost and availability of medicine in Tanzania. Product approvals granted by Tanzanian drug regulatory authority were analyzed on the basis of exporting countries, molecules and therapeutic categories. The market compet...

Srikanth Ineedi , Deepak Kumar Jena*, Poduri Balaram , Swaroopa Bobba

Manager, International Business Development, UAS Laboratories, Inc, 9953 Valley View Road, Eden Prairie, MN 55344

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3156-62

3156-3162

1930

588

31.

BIOSYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES USING ENDOPHYTIC FUNGI ASPERGILLUS CONCIUS, PENICILLIUM JANTHINELLUM AND PHOMOSIS SP.

The present study of seventy one endophytic fungi isolated from Avicennia marina, Suaeda monica and Rhizophora mucronata plant leaf. Among 34 genera and 71 species was identified by Lactophenol cotton blue mounting techniques. To induce the biosynthesis of silver nanoparticles (AgNO3) using Aspergillus conicus, Penicillium janthinellum and Phomosis sp. And evaluate their antimicrobial potential. T...

R. Bharathidasan and A. Panneerselvam

P.G. Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous) Poondi-613503, Thanjavur Dist, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3163-69

3163-3169

2185

940

32.

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF METFORMIN HYDROCHLORIDE IN TABLET DOSAGE FORM

A simple, economic, sensitive, precise and accurate UV spectrophotometric method was developed and validated for quantification of Metformin hydrochloride in bulk and in tablet dosage form. Adequate drug solubility and maximum assay sensitivity was found in 0.01N sodium hydroxide at 233nm. Calibration graph constructed at 233nm was linear in concentration range of 1-25μg/ml with correlation coeff...

Reatul Karim*, Nurunnahar Poly and Rebecca Banoo

Department of Pharmacy, State University of Bangladesh- 77, Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3170-74

3170-3174

4604

875

33.

IMPACTS OF HIGH DIETARY FAT ON SERUM CHOLESTEROL AND DEVELOPMENT OF FATTY LIVER IN RATS

The present study was designed to evaluate the impacts of high dietary fat on serum Total cholesterol and fatty liver syndrome in rats.  Rats are fed on diets containing cholesterol; they develop fatty livers which are characterized by the presence in the liver of excessive amounts of cholesteryl esters, and glyceride. Increasement of glyceride content depend on a number of factors, such as the d...

Rajesh Pandey and Narendra Kumar

Department of Biochemistry, Awadesh Pratap Singh University, Rewa 486003, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3175-78

3175-3178

1580

433

34.

BINDING EFFICACY AND ELUCIDATION OF QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP OF ACETANILIDE AND ITS DERIVATIVES WITH BOVINE SERUM ALBUMIN AND THEIR INHIBITION AGAINST COX1

Serum albumins are the most abundant proteins in plasma with many physiological functions. Among them, BSA has a wide range of functions involving the binding, transport and delivery of fatty acids, porphyrins, bilirubin, steroids, etc and it is home to specific binding sites for metals, pharmaceuticals and dyes. Recently, nanotechnology has become a popular term in the current science and technol...

V. Violet Dhayabaran*, S. Aishwarya and R. Renganathan

Coordinator, Department of Biotechnology and Bioinformatics, Bishop Heber College, Tiruchirappalli-17, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3179-85

3179-3185

1710

520

35.

α-GLUCOSIDASE AND α -AMYLASE INHIBITORY ACTIVITIES OF RAPHANUS SATIVUS LINN.

Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. There has been an enormous interest in the development of alternative medicines for type 2 diabetes, specifically screening for phytochemicals with the ability to delay or prevent glucose absorption. The goal of the present study is to evaluate the invitro antidiabetic activity of Rap...

Ramachandran Vadivelan*, Sanagai Palaniswami Dhanabal , Ashish Wadhawani and Kannan Elango

Assistant Professor, Department of Pharmacology, JSS College of Pharmacy, (Off Campus of JSS University, Mysore), Ooty, Nilgiris-643001, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3186-88

3186-3188

3691

867

36.

HEPATOPROTECTIVE ACTIVITY OF ALCOHOLIC AND AQUEOUS EXTRACTS OF ALLIUM CEPA LINN. (LILIACEAE) IN RATS

In the present study, we have chosen a plant named Allium cepa Linn(Liliaceae) to evaluate its hepatoprotective activity in experimental animals. Different pharmacological activities are reported with different parts of this plant. Some of its medicinal properties reported are as stimulant, diuretic, anti-tubercular, anthelmintic, and used for various diseases like  diabetes, skin diseases, rheum...

Riyaz Shaik*, R.L. Manisha , Suresh Babu Sayana and Rajesh Pal

Department of Pharmacology, V.L. College of Pharmacy, Raichur-584 103, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3189-95

3189-3195

1948

0

37.

INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN-DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)

Cyclin dependent kinases (CDKs) are known as cell cycle regulators in eukaryotic cell cycle. Different CDKs (CDK2, CDK4 etc.) are having structure homology among them. Using computer based molecular modeling tools, interactions between naturally occurring terpene based compounds with crystal structure of CDK4 mimic CDK2 enzyme having PDB ID : 1GII. Using In-silico techniques, the binding energies ...

Sunil H. Ganatra* and Amita S. Suchak

Department of Chemistry, Institute of Science, Civil Lines, Nagpur-440 001, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3196-03

3196-3203

1633

600

38.

EFFECT OF GARLIC ADMINISTRATION ON RAT HEART MITOCHONDRIAL ENZYMES AFTER NOISE STRESS EXPOSURE

Background: Noise has been recognized as one of the risk factors for cardiovascular diseases. Garlic is one of the oldest medications used in human culture. Garlic is used in herbal medicine for thousands of years and also as one of the main food ingredient. The present study was aimed to investigate the cardioprotective effect of garlic after noise exposure in Wistar albino rats. Methods: Anim...

Sathya Narayanan Govindarajulu*, Gajalakshmi Ganesh and Sheela Devi Rathinasamy

Assistant Professor, Institute of Physiology and Experimental Medicine, Madras Medical College, Chennai 600003, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3204-10

3204-3210

1507

580

39.

DEVELOPMENT AND EVALUATION OF PUSH-PULL BASED OSMOTIC DELIVERY SYSTEM FOR ROPINIROLE

Ropinirole hydrochloride is indicated in Parkinson’s disease and Restless leg syndrome. In advanced Parkinson’s disease the usual dose of Ropinirole hydrochloride is 0.25 to 5 mg three to four times a day. Hence, an attempt was made to develop a once-a-day controlled release Osmotic drug delivery system. This may offer significant patient benefits by providing enhanced efficacy and reduced sid...

Adarsh Shah*, Viral Shah and U.M. Upadhyay

Sigma Institute of Pharmacy, Vadodara, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3211-18

3211-3218

1531

621

40.

WOUND HEALING POTENCY OF ETHANOLIC EXTRACT OF LEUCAS URTICIFOLIA IN EXPERIMENTAL ANIMALS

The present study was planned to investigate the effect of ethanolic extract of Leucas Urticifolia on resutured incision, excision and burn wounds in Wistar rats. Resutured incision, excision and dead space wounds were inflicted under light ether anaesthesia aseptically. In incision wound model the control animals receive only distilled water and all test animals were treated with different doses ...

Sushil Suthar* and Ritesh Patel

22-Gandhi Nagar, Sri Ganganagar, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3219-24

3219-3224

1573

476

41.

PREVALENCE OF DIETARY SUPPLEMENTS AND AYURVEDIC MEDICINES’ INTAKE BY PATIENTS TAKING PRESCRIBED ALLOPATHIC MEDICINES AT LUCKNOW

Aim: Present study was done to know the prevalence of the use of dietary supplements and ayurvedic drugs by patients taking allopathic drugs. Introduction: Allopathic drugs are likely to act with ayurvedic drugs and dietary supplements and concurrently used. This concept is usually not recognized by the patients and physicians. Sometimes this may prove dangerous. Present study was done to find ...

Rakesh C. Verma* and Rakesh K. Dixit

Department of Pharmacology and Therapeutics, Chhatrapati Shahuji Maharaj Medical University, Lucknow-226003, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3225-27

3225-3227

1506

466

42.

ANTIBACTERIAL ACTIVITIES OF TRIGONELLA FOENUM-GRAECUM AND ZINGIBER OFFICINALE

An in vitro study was conducted for screening antibacterial activities of seeds of Trigonella foenum-graecum (fenugreek)and rhizomes of Zingiber officinale (ginger), in their different forms viz.  aqueous extracts, essential oils and powders against some common food borne pathogens. Bacterial strains involved in the study were Bacillus cereus (MTCC 430), Enterococcus feacalis (MTCC 439), Escheric...

Mamta Bhatia* and Alka Sharma

Department of Food Technology, Guru Jambheshwar University of Science and Technology, Hisar-125021, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3228-32

3228-3232

1450

560

43.

ESTIMATION OF NELFINAVIR MESYLATE IN PHARMACEUTICAL DOSAGE FORM BY SPECTROFLUORO- PHOTOMETRY

A new specific, selective and inexpensive spectrofluorophotometric method has been developed for determination of Nelfinavir mesylate in bulk drug and its dosage form. Fluorescence spectrum of Nelfinavir mesylate in methanol showed excitation wavelength at 253 nm and emission wavelength at 508 nm. The calibration curve for Nelfinavir mesylate was found to be linear over the concentration range of ...

A.J. Patel , P.K. Shelat , A.N. Lalwani*

Department of Pharmaceutics, K.B. Institute of Pharmaceutical Education and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar-38 20 23, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3233-36

3233-3236

1509

550

44.

FORMULATION AND EVALUATION OF TIZANIDINE SUSTAINED RELEASE MATRIX TABLETS USING HYDROXY PROPYL METHY CELLULOSE

Tizanidine is a muscle relaxant agent, with the half life of 2.5 hours and requires daily doses to maintain adequate plasma concentrations. The present study was undertaken to with an aim to formulation development and evaluation of Tizanidine hydrochloride sustained release tablets using hydrophilic polymer to sustain the action of Tizanidine. Different batches of Tizanidine hydrochloride were pr...

Ankita Srivastava

Department of Pharmaceutical sciences, H.N.B. Garhwal University, Srinagar, Garhwal, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3237-44

3237-3244

2093

752

45.

ANTIMICROBIAL ACTIVITY OF PRICKLY CHAFF (ACHYRANTHES ASPERA) SEED TRYPSIN INHIBITOR

Trypsin inhibitor (AATI) was purified from the seeds of Achyranthes aspera to homogeneity by conventional methods and its antimicrobial activity was tested on selected pathogenic microbes. The inhibitor significantly affected the growth of Proteus vulgaris followed by Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia with zones of inhibition recorded as 28mm, 26mm...

Geetha Konala, Lavanya Seva and Siva Prasad Davuluri*

Department of Biochemistry, Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3241-48

3241-3248

1878

585

46.

QSAR STUDY TO PREDICT ANTI-AMOEBIC ACTIVITIES OF PYRAZOLINE AND DIOXAZOLE DERIVATIVES WITH THE HELP OF PM5-BASED DESCRIPTORS

In quest of better anti-amoebic agents, quantitative structure-activity relationship (QSAR) studies were performed on a series of pyrazoline & dioxazoles derivatives with the help of PM5 calculations and geometry optimizations using CAChe software. Multiple Linear Regression (MLR) analysis was performed to derive QSAR models using the descriptors, molecular weight (MW), conformation minimum en...

Anil K. Srivastava* and Ratna Gupta

Department of Chemistry, M.L.K. (P.G.) College, Balrampur, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3249-58

3249-3258

1740

761

47.

EVALUATION OF ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF OCIMUM CANUM IN PREVENTION OF RENAL ISCHEMIA

The ethanolic extracts of aerial part of Ocimum canum (OC) were studied for its antioxidant activity and its role to prevent renal ischemia. The in vitro antioxidant models used were DPPH radical scavenging activity, Hydroxyl peroxide radical scavenging method, reducing power assay & FRAP assay. The study was carried out at different concentration (250, 500, 1000, 2000 µg/ml). Further, the an...

Jyotirmoy D. Choudhury*, Deepika Sharma , Vivek Mayank , Saiprasanna Behera , Suhail Hamid

Department of Pharmacology, Royal College of Pharmacy and Health Sciences, Brahmapur-760002, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3259-66

3259-3266

1630

525

48.

RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METFORMIN HYDROCHLORIDE, ROSIGLITAZONE AND SITAGLIPTIN – APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS

A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-diabetic drugs Metformin hydrochloride (MT), Rosiglitazone (RT) and Sitagliptin (ST). The separation was achieved on ACE 3 150 mm X 4.6mm, 3.5µm column using gradient method. The mobile phase at a flow rate of 1.5 mL min−1 consisted of 10 mM sodium hexane sulphonate mo...

Hitesh P. Inamdar*and Ashok A. Mhaske

Research Officer, Getz Pharma Research Pvt Ltd. Ambernath (East), Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3267-76

3267-3276

2583

911

49.

EARLY CO-ADMINISTRATION OF VITAMIN E ACETATE AND METHYLCOBALAMIN PREVENT PROGRESSION OF NEUROPATHIC COMPLICATION IN DIABETIC RATS

Oxidative stress has been implicated in the eiteology of diabetic neuropathy (DN) and anti-oxidants have shown to ameliorate this condition. Previous studies have indicated that early treatment with vitamin E acetate (VE) and methylcobalamin (MCA) attenuated surgery induced neuropathy in rats. The aim of this study was to test the effect of early co-administration of VE (50 mg/kg) and MCA (500µg/...

A.S. Morani

Department of Pharmacology, Bharati Vidyapeeth University, Paud Road, Erandwane, Pune- 411038, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3277-82

3277-3282

1488

520

50.

FORMULATION AND OPTIMIZATION OF OSMOTICALLY CONTROLLED, MICROBIALLY TRIGGERED COLON TARGETED SYSTEM USING FACE CENTERED CENTRAL COMPOSITE DESIGN

The purpose of present investigation was to achieve successful delivery especially to colon using microbially triggered, osmotically controlled approach. Prednisolone was chosen model drug for treatment of inflammatory bowel disease (IBD). Prednisolone-β-cyclodextrin complex were prepared and phase solubility study was carried out. Cellulose acetate solution containing chitosan was used to prepar...

Sapna Saini and Rajesh Saini*

Janta College of Pharmacy, Butana, Sonipat-131 302, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3283-95

3283-3295

1388

488

51.

DEVELOPMENT AND EVALUATION OF VERAPAMIL HYDROCHLORIDE XANTHAN GUM MICROCAPSULES AS CONTROLLED DRUG DELIVERY SYSTEM

In the present study, the microspheres containing Verapamil hydrochloride xanthan complexes encoated with ethyl cellulose by emulsion solvent evaporation method. DSC shown absence of any new endothermic peak, disappearance of no shift of endothermic peak confirmed that there is no any interaction between drug, excipients and the drug was thermally stable. Drug polymer ratio was altered while the o...

B.E. Wanjari* and N.J. Gaikwad

Manoharbhai Patel Institute of Pharmacy, Kudwa, Gondia- 441 614, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3296-03

3296-3303

1531

480

52.

PHYTOCONSTITUENTS OF CYPERUS ROTUNDUS L. THAT ATTRIBUTE TO ITS MEDICINAL VALUE AND ANTIOXIDANT PROPERTY

Cyperus rotundus L. is a medicinal herb widely used in the ancient Ayurvedic and Chinese traditional medicine. In the earlier investigations it has been primarily studied for its antioxidant properties. The present study explores the various phytochemicals present in the plant so as to substantiate its antioxidant property and also unravels the several phytoconstituents that contribute to its vari...

J. Lydia* and D. Sundarsanam

151, 2nd Main street, NesamonyNager, Nagercoil- 629001, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3304-08

3304-3308

1876

725

53.

PURIFICATION AND CHARACTERIZATION OF ALKALINE PHOSPHATASE FROM DOLICHOS LAB-LAB AND ITS INVITRO DEPHOSPHORYLATION ACTIVITY ON NUCLEIC ACIDS

Phosphatase serves several functions in plant metabolism including growth governance, phosphorous level control, starch breakdown etc. Alkaline phosphatases, acting at an alkaline pH 8, are a significant class of enzymes that catalyze release of phosphate esters especially. This enzyme study is so far limited only to animal source and partly to microbial sources, in terms of clinical research. Alt...

Praveen Kumar Vemuri*, Rama Krishna Yadam, Naga Sravani Jandhyala, Sreelekha Revur, Ramya Hari Priya Velampati and Anusha Kalapala

Center for Genomics & Proteomics, Department of Biotechnology, K. L. University, Green Fields, Vaddeswaram, Guntur District, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3309-13

3309-3313

2119

486

54.

DIRECT SPECTROPHOTOMETRIC DETERMINATION OF SATRANIDAZOLE

A direct spectrophotometric method was developed by the authors for the detection and determination of satranidazole in pure form as well in pharmaceutical formulations in the form of tablets and capsules. The method was based on the formation of a reddish-purple color dye, due to the diazotization reaction between the nitro group of the drug sample, sulphanilamide and NEDA. The drug sample dissol...

G.V.S.R. Pavan Kumar*, P.Y. Venkata Rao, B. Krishna Kumar, V. Prasanthi and B. Sreerama Murty

Department of Chemistry, Maharajah’s Post Graduate College, Vizianagaram-535002, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3314-16

3314-3316

1610

578

55.

DEVELOPMENT AND VALIDATION OF AN UPLC METHOD FOR IN-VITRO STUDY OF GLIPIZIDE EXTENDED RELEASE TABLETS

A Reversed Phase Ultra Performance Liquid Chromatographic (RP-UPLC) method was developed for the determination of glipizide (GLI) in in-vitro study during formulation development. The chromatographic separation was achieved on a Acquity UPLC BEH C18 (50 mm × 2.1 mm, 1.7 µm) column, with a mixture of 55 volumes of methanol and 45 volumes of buffer contain 0.001M sodium dihydrogen phosphate in iso...

Harshal Kanubhai Trivedi*, Nayan Kshtri, Vipul Patel and Vinay Roa

Analytical Research Lab, Cadila Pharmaceutical Ltd, Dholka-387 810, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3317-22

3317-3322

2336

644

56.

PHYTOCHEMICAL SCREENING AND IN VITRO ANTIMICROBIAL INVESTIGATION OF THE METHANOLIC EXTRACT OF CENTELLA ASIATICA LEAVES

The methanol extract of Centella asiatica (Family:Umbelliferae) was studied for its phytochemical and pharmacological Activities. This study of the extracts indicates the presence ofReducing Sugar Tannins, Alkaloids, Sapponins and.The pharmacological study include Antimicrobial activities.The extract of the plant  showed activity against a wide a variety of microorganism’s .All the activities w...

Rishikesh*, Md. Mofizur Rahman , S.M. Siddiqul Islam and Md. Moshfiqur Rahman

B. Pharm, MS. Pharm. Tech., Department of Pharmacy, Bangladesh University, Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3323-30

3323-3330

1934

699

57.

A STUDY OF RELATIONSHIP BETWEEN ANTIBIOTIC RESISTANCE AND MOLECULAR CHARACTERISTICS OF ESCHERICHIA COLI ISOLATES OBTAINED FROM DIFFERENT HUMAN CLINICAL SPECIMENS AGAINST MULTIPLE ANTIBIOTIC RESISTANCE (MAR) INDEX IN BAREILLY (INDIA) REGION

To analyse the situation of antibiotic resistance, a total of 77 E. coli isolates from urine, pus, sputum and endo-tracheal aspirate were screened for their antibiograms for antibiotic resistance, multiple antibiotic resistance (MAR) index for evaluating the spread of resistance and plasmid profiles for the presence and characterization of plasmids. Very high resistance level (>90%) was detecte...

Sandhya Hora* and Ziledar Ali

Central Research Laboratory, Department of Biochemistry, Shri Ram Murti Samarak-Institute of Medical Sciences, Nainital Road, Bareilly-243202, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3331-36

3331-3336

1977

462

58.

IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS USING QUALITY CONTROL TESTS

Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the commercially available tablet brands of paracetamol. Tablets of two manufacturers of the formulation were eval...

Satinder Kumar*, Shashikant and Ruchika Agnihotri

Global College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3337-41

3337-3341

9539

1566

59.

IN VITRO CHARACTERIZATION OF NATURAL MUCOADHESIVE AGENT ISOLATED FROM OCIMUM AMERICANUM SEED

Aim of present investigation was to isolate natural mucoadhesive agent from Ocimum americanum seeds and characterize through in vitro mucoadhesion methods, FTIR and DSC studies. Mucoadhesion force of isolated natural mucoadhesive agents and synthetic polymer Carbopol 934P was determined using in vitro mucoadhesion methods viz. Wihelmy’s method, falling sphere method and modified physical balance...

P. Perumal, Avinash B. Gangurde* and Prashant S. Malpure

JKK Nataraja College of Pharmacy, Komarapalayam-638 183, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3342-46

3342-3346

1924

504

60.

A SENSITIVE RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DIETHYLCARBAMAZINE AND LEVO-CETIRIZINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of Diethylcarbamazine and Levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with Diethylcarbamazine and Levocetirizine simultaneously. HPLC-PDA detector at the λmax of 253nm, using Hypersil-BDS C18 (250×4.6 mm. 5 μ) column. ...

Krishna Vamsi Movva*, B. Jayalakshmi, R. Vijay Amritharaj and Sandeep Chilamkurthi

Department of Pharmaceutical Analysis, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam-638183, Namakkal, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3347-53

3347-3353

1499

771

61.

PHYTOCHEMICAL SCREENING AND DIURETIC ACTIVITY OF ALLIUM SATIVUM STEROIDAL AND TRITERPENOID SAPONIN FRACTION

Allium sativum L. (Liliacea) is a perennial bulb with a tall, erect flowering stem. The bulb of the plant has been used in many parts of the world as a stimulant, carminative, antiseptic, expectorant, anthelmintic and diuretic. This study has been planned to assess the diuretic activity of fresh garlic bulb extract targeting the steroidal and triterpenoidal saponin content. The rats were randomly ...

S. Tiwari, B. Sirohi, A. Shukla and P. Bigoniya *

Radharaman College of Pharmacy, Fatehpur Dobra, Ratibad, Bhopal- 462 002, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3354-61

3354-3361

2948

622

62.

ANTI-DIABETIC ACTIVITY OF LAGENARIA SICERARIA PULP AND SEED EXTRACT IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS

The aim of the present study was to evaluate the possible anti-diabetic potential of Lagenaria siceraria pulp extract (LSPE) and Lagenaria siceraria seed extract (LSSE) against the pancreatic damage from alloxan-induced diabetes in rats related to diabetes mellitus. Lagenaria siceraria induced significant reduction in blood glucose and increasing of serum insulin, our data indicate that the level ...

Somshuvra Bhattacharya* and Binay Das

Gurunanak Institute of Pharmaceutical Science and Technology 157/F Nilgunj Road, Kolkata-114, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3362-69

3362-3369

3403

934

63.

DEVELOPMENT AND BIOEQUIVALENCE STUDY OF OLANZAPINE 10mg TABLETS

Generic drugs are lower-cost versions of patent-expired original brand-name medications. According to guidelines of regulatory agencies of the Canada, US and European Union, a generic drug must be “identical, or bioequivalent to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use”. Bioequivalence is decreed when the...

Ravindra Waykar* and Yogesh Kulkarni

Department of Pharmacology, SPP-School of Pharmacy & Technology Management, SVKM’s NMIMS University, Mumbai - 400 056, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3370-75

3370-3375

3770

889

64.

ESTIMATION OF MANIDIPINE DIHYDROCHLORIDE BY A NEW RP-HPLC METHOD

A rapid reverse phase high performance liquid chromatographic method was developed for the estimation of Manidipine dihydrochloride in its pure form as well as in tablet dosage forms. Chromatography was carried out on an phenomenex C18 column (250´4.6mm, 5 µm), using a mixture of acetonitrile and water (80: 20 v/v) with pH adjusted to 3.5 with ortho phosphoric acid (0.1 % v/v)  as the mobile ph...

Raja Sundararajan*, Christopher Vasanth Kumar and Jayaveera

GITAM Institute of Pharmacy, GITAM University, Visakhapatnam- 530 045, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3375-78

3375-3378

1822

544

65.

ASSESSMENT OF BIOTHERAPEUTIC POTENTIAL OF PIMENTA DIOICA (ALLSPICE) LEAF EXTRACT

All-spice (pimenta) is one of the under-utilized resources available in the tropical regions of the globe. It is a variety of sweet pepper used as a spice and its leaves are used for traditional culinary purpose. Researchers have studied the antioxidant potentials of the berries of the plant, but no documented work is reported on its stem, leaf and roots for antimicrobial properties. Thus, the pre...

Pratima Khandelwal*, Raje Siddiraju Upendra , Zeynab Raftaniamiri, Geetha Gujjar Ramachandra

Professor & HOD, Dept. of Biotechnology, New Horizon College of Engineering, Ring Road, Bellandur Post, Marathahalli, Bangalore -560103, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3379-83

3379-3383

1932

525

66.

DESIGN, DEVELOPMENT AND IN VITRO EVALUATION OF CONTROLLED RELEASE GEL FOR TOPICAL DELIVERY OF QUETIAPINE USING BOX- BEHNKEN DESIGN

The purpose of this work was to develop and characterize a vesicular drug carrier for topical delivery of Quetiapine to overcome the problems related with oral route that is high first pass metabolism and fluctuating drug plasma concentration. The effects of key formulation variables on entrapment efficiency (EE %), vesicle size and in vitro drug permeation were studied using a Box- Behnken design...

Hardik K. Patel*, Chandni V. Shah, Viral H. Shah and Umesh M. Upadhyay

Department of Pharmaceutics, Sigma institute of Pharmacy, Baroda, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3384-98

3384-3398

2209

772

67.

ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL OF MURRAYA KONIGII AGAINST HUMAN CARIOGENIC PATHOGENS

This study was to evaluate the antioxidant and antibacterial efficacy of herbal crude extract of Murraya koenigii againsthuman Cariogenic pathogens. In this study Methanolic extract of Murraya koenigii were studied for phytochemical composition and GC-MS for active compound. Antioxidant potential assay by 1,1-Diphenyl- 2-picrylhydrazyl (DPPH), 2, 2’-azinobis-3 ethylbenzothiazoline-6-sulfonic aci...

Deepak Dwivedi*, Rakesh Kumar Patidar and Vinod Singh

Scientist Microbiology, Minor Forest Produce Processing & Research Center, Barkheda Pathani, Bhopal, M.P. Pincode-462021, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3399-06

3399-3406

1713

463

68.

COMPARATIVE SAFETY AND COST EFFECTIVE ANALYSIS BETWEEN ACECLOFENAC, LORNOXICAM AND DICLOFENAC IN PATIENTS OF MUSCULO SKELETAL DISORDER

Newer NSAIDs like Aceclofenac and Lornoxicam are being marketed by pharmaceutical industries with claims of better efficacy and safety than conventional NSAIDs like Diclofenac. So this  study  aims  to  comparatively  assess  the safety, efficacy  and cost of Aceclofenac,  Lornoxicam  and Diclofenac in patients of musculoskeletal disorders. Patients presenting with musculoskeletal disorde...

K.P. Patnaik*, P. Das, S. Hota , B. N. Mohapatra , S. Mohapatra , S. Nayak , S. Panigrahi

Department of Pharmacology, S.C.B. Medical College, Cuttack-753007, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3407-11

3407-3411

2817

975

69.

EFFECT OF AMLODIPINE ON ORAL GLUCOSE INDUCED GLYCEMIC CHANGES IN NORMAL ALBINO RATS

Objective: To determine the effect of amlodipine on blood glucose levels through oral glucose tolerance test in normoglycemic albino Rats and the magnitude of its effect on basal v/s glucose induced glycemic value compared to control. Methods: Rats were divided into  control and  test groups to study  the effect of glucose induced glycemic changes in  normal rats following oral administrati...

Sushma V. Naidu*, R.N. Suresha, J.C. Huralikuppi, V. Ashwini, A.M. Satish and M. Brahadeesh

Department of Pharmacology, JSS Medical College, (A Constituent College of JSS University, Mysore), SS Nagar, Mysore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3412-17

3412-3417

1744

565

70.

PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT ACTIVITY OF AQUEOUS AND HYDROALCOHOLIC EXTRACT OF BACOPA MONNIERI LINN.

The present study was undertaken to investigate in-vitro antioxidant activity of aqueous and hydroalcoholic extract of whole plant of Bacopa monnieri Linn. Family- Scrophularaceae. The  total  Phenolic content  was  determined  using folin  ciocalteau method while the total  flavonoid  content was determined using  aluminium  chloride  method. In vitro antioxidant activity was evaluated...

Monic Shah*, Yerram Raju Behara and B. Jagadeesh

Department of Pharmacology, Sri Indu Institute of Pharmacy, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3418-24

3418-3424

2310

728

71.

SYNTHESIS AND MICROBIAL STUDIES OF SOME NOVEL SCHIFF BASE CONTAINING PYRIMIDINE

6-chloro 2, 4-diamino pyrimidine reacts with various aromatic aldehyde. Finally, the product was characterized by conventional and instrumental methods. Their structures were determined and important therapeutic properties were studied....

Kalpesh S. Parikh* and Sandip P. Vyas

Department of Chemistry, Sheth M.N. Science College, Patan-384 265, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3425-27

3425-3427

1727

553

72.

A COMPARATIVE STUDY OF ROSIGLITAZONE AND PIOGLITAZONE TO EVALUATE THE CARDIOVASCULAR EFFECTS IN HIGH FRUCTOSE DIET INDUCED HYPERTENSIVE RATS

Thiazolidinediones (TZDs) were widely used for the treatment of type 2 diabetes. Recent studies have shown that TZDs have paradoxical effects on cardiovascular diseases. The objective of the present study was to investigate the effect of TZDs (Rosiglitazone and Pioglitazone) in High Fructose Diet (HFD) induced hypertension in rats. HFD was given for 14 weeks. After 8 weeks of hypertension inductio...

Arghya Biswas* and Syed Imam Rabbani

Department of Pharmacology, Al-Ameen College of Pharmacy, Opp. Lalbagh Main Gate, Hosur Road, Bangalore-560027, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3428-32

3428-3432

1587

477

73.

SIMULTANEOUS ESTIMATION OF SUMATRIPTAN SUCCINATE AND NAPROXEN SODIUM BY REVERSE PHASE HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORM

This investigation describes a new precise, sensitive and accurate RP-HPLC method for the Simultaneous estimation of Sumatriptan succinate and Naproxen Sodium in Bulk and Tablets. The resolution of two drugs was achieved on XTerra C18 (150mm x 4.6mm i.d., 3.5mm particle size) column with UV detection at 284nm and the mobile phase consists of Buffer and Acetonitrile (25:75 v/v). Using chromatograph...

Kamepalli Sujana*, D Gowri Sankar and Konda Abbulu

Assistant Professor, Department of Pharmaceutical Analysis, University college of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna nagar, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3433-37

3433-3437

2527

1131

74.

PHARMACOGNOSTIC STUDIES ON DIOSPYROS MELANOXYLON

Diospyros melanoxylon is a medium-sized tree or shrub which belongs to the family Ebenaceae. The whole plant is medicinally important and cures several diseases. Therefore, in this context the detailed pharmacognostic study of various parts like leaf, stem, petiole and root has been carried out with the aim to establish its Pharmacognostical standards. The parameters selected were microscopical st...

Sunitha Chintala*, Anil Kandhula, Yasodha Krishna Janapathi, Fayaz Khan Md and Divya Vani P

Assistant Professor, Department of Pharmacognosy, Sri Sarada College of Pharmacy, Affiliated to JNTUH, Bhongir, Nalgonda-508116, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3438-43

3438-3443

2627

894

75.

MOUTH DISSOLVING TABLETS OF LOSARTAN POTASSIUM: FORMULATION AND EVALUATION

Losartan potassium is an angiotention receptor antagonist, used in the management of hypertension. The objectiveof the proposed research work is to prepare and evaluate the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Mouth dissolving tablets (MDTs) were prepared by direct...

Satyabrata Bhanja*, Danendra ku Hardel and Muvvala Sudhakar

Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda Secunderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3444-53

3444-3453

2678

619

76.

PREVALENCE OF SERUM THYROID HORMONES AND MENSTRUAL IRREGULARETIES WITH INFERTILITY IN UTTAR PRADESH, INDIA

It is important to predict the serum thyroid hormones level in females during infertility to prevent its occurrence later on. In this study, we studied serum thyroid hormones and menstrual irregularities during infertility. A case control study was performed in 75 infertile patients with menstrual irregularities and 50 healthy matched women. Three biochemical parameters were measured in serum, hor...

Neha Sharma* and Simant Baliar Singh

Department of Biochemistry, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly- 243 202, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3454-57

3454-3457

1617

526

77.

ESTIMATION OF TOTAL POLYPHENOLIC CONTENT IN AQUEOUS AND METHANOLIC EXTRACTS FROM THE BARK OF ACACIA NILOTICA

Plant polyphenols have been studied largely because of the possibility that they might underlie the protective effects afforded by fruit and vegetable intake against cancer and other chronic diseases. The objective of the present study is to estimate the total polyphenolic content in aqueous and methanolic extract prepared from the bark of Acacia nilotica plant species. Acacia nilotica (L.) Willd....

Mayank Tenguria*, Priyankar Chand and Ravi Upadhyay

Vibhav Institute for Research & Application of Biotech, 114/9A, Saket Nagar, Bhopal-462024, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3458-61

3458-3461

2020

797

78.

DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROMETRIC METHOD FOR ESTIMATION OF WATER SOLUBLE VITAMIN RIBOFLAVIN

The present study describes a simple, accurate, precise and cost effective UV-Visible spectrophotometric method for the estimation of Riboflavin raw material. The Riboflavin is water soluble vitamin, so the solvent used throughout the experiment was 0.1N NaOH, the absorption maxima of drug was found at 445 nm. Beer’s law was obeyed in the range of 5ppm-30ppm. the developed method was successfull...

Himanshi Shah*, Shraddha Patel, Bhavik Patel, Nitin Solanki, Nurudin P. Jivani, Digbijay B. Kumar

Department of Quality Assurance, C.U. Shah College of Pharmacy and Research, Gujarat Technological University, Wadhwan-363 065, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3462-66

3462-3466

5426

843

79.

DASHAMULARISHTA: PHYTOCHEMICAL AND ANTIMICROBIAL SCREENING AGAINST EFFECT OF ENVIRONMENTAL POLLUTION

Pollution have a serious impact on human health and environment. The incidences of various diseases are becoming prominent with the increase in rate of population. The diseases mainly include respiratory disorders, cardiovascular disorders, throat inflammation, skin infections etc. In the present study,  widely claimed crude drug Dashamularishta, have been screened for their antibacterial activit...

Sudhanshu , Sandhya Mittal , Nidhi Rao and Ekta Menghani *

Mahatma Gandhi Institute of Applied Sciences, JECRC University, Jaipur-22, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3467-71

3467-3471

1394

425

80.

ANTIOXIDANT POTENTIAL OF GARCINIA SPECIES FROM SONITPUR DISTRICT, ASSAM, NORTH EAST INDIA

The fruits of Garcinia pedunculata Roxb. ex Buch.-Ham., G. xanthochymus Hook. f. and G. morella (Gaertn.) Desr. collected from Sonitpur district of Assam, India were evaluated for the antioxidant potential and total phenolic content. The methanolic extract of these fruits were subjected to DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay for determining the free radical inhibition property and Folin Cio...

Baikuntha Jyoti Gogoi , Jambey Tsering*, Hui Tag and Vijay Veer

Project Fellow and Ph.D. Scholar, Department of Botany, Rajiv Gandhi University, Rono Hills, Doimukh – 791112, Arunachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3472-75

3472-3475

3020

1462

81.

BIOCHEMICAL ESTIMATION OF PRIMARY METABOLITES OF CASSIA NODOSA BUNCH.

Cassia nodosa Bunch.is an ornamental tree belonging to family Leguminosae, popularly known as Pink Shower is a perennial tree. Laboratory evaluations were made to asses the study of primary metabolites in different plant parts of Cassia nodosa Bunch. The highest amount of soluble sugars (10.27mg/ gdw), lipids (32.36mg/gdw), phenols (20.0mg/gdw), DNA (11.78mg/gdw) and Chlorophyll- a+b (0.94mg/gdw) ...

R.A. Sharma, Daulat Singh, Ankita Yadav* and Richa Bhardwaj

Plant Physiology and Biochemistry Lab., Lab. no. 14, Department of Botany, University of Rajasthan, Jaipur-302 004, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3476-80

3476-3480

1752

39

82.

ANTIMICROBIAL ACTIVITY OF ALKALOIDS OF TRIDAX PROCUMBENS L. AGAINST HUMAN PATHOGENS

Tridax procumbens L. is a well known medicinal plant. In the present study alkaloids from pedicle and buds of the plant were extracted and evaluated for antimicrobial activity by ‘Disc Diffusion Assay’ against selected bacteria (Escherichia coli, Staphylococcus aureus and Proteus mirabilis) and fungi (Aspergillus flavus, Aspergillus niger, Candida albicans and Trichophyton mentagrophytes). Min...

A. Jindal* and P. Kumar

Laboratory of Plant Tissue Culture and Secondary Metabolites, Department of Botany, University of Rajasthan, Jaipur-302055, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3481-85

3481-3485

2276

485

83.

A STUDY OF CARDIOVASCULAR AND ANTIMICROBIAL EFFECTS OF TINOSPORA CORDIFOLIA

Tinospora cordifolia is known for a wide range of medicinal properties. In this study, cardiovascular and antimicrobial properties of aqueous and ethanolic extracts of Tinospora cordifolia were evaluated. Dose dependent negative ionotropic and chronotropic effects were observed with both aqueous and ethanolic extracts. The effects were antagonized by atropine indicating involvement of muscarinic r...

J. Archana* and M.P. Kusuma

RBVRR Women’s college of pharmacy, Barkathpura, Hyderabad-500027, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3486-89

3486-3489

1487

504

84.

ORAL AND SYSTEMIC SIDE EFFECTS OF CANCER CHEMOTHERAPY AND EFFECT OF BENZYDAMINE MOUTHWASH IN ORAL MUCOSITIS

Aim: To check the effectiveness of 0.15% Benzydamine hydrochloride on oral mucositis secondary to cancer chemotherapy Methods: In the past few years, multiple cases were referred to our department for the management of oral manifestations of cancer chemotherapy for various malignancies. Out of these patients, we selected 5 patients and used a simple, inexpensive treatment modality in considerat...

Anagha Shete* , Samapika Routray , Mahesh S. Chavan , Nikhil N. Diwan and Mrinal Shete

MDS, Senior Lecturer, Department of Oral Medicine and Radiology, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune- 411018, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3490-92

3490-3492

1783

743

85.

PREPARATION AND IN-VITRO EVALUATION OF MICRO EMULSION OF ANTI-HYPERTENSIVE DRUG: VALSARTAN

Valsartan is an orally administered ACE inhibitor for the treatment of hypertension and cardiac failure, but its solubility and oral bioavailability are poor. The objective of investigation is to formulate a   microemulsion drug delivery system of valsartan using minimum surfactant concentration that could improve its solubility and oral bioavailability. Valsartan microemulsion were prepared by ...

Nishit Patel, Beny Baby, K. Ramesh, Prakash Rao and S. Rajarajan

Department of Pharmaceutics, Karnataka College of Pharmacy, Hegde nagar, Bangalore-560064, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3493-01

3493-3501

2991

929

86.

ANTI-GLYCATION EFFECT OF WHITTON ROOT (EULOPHIA NUDA) IN-VITRO CONDITION

Non enzymatic glycation takes place when elevated levels of reduced sugars react with amino groups of proteins and is called as advanced glycation end products (AGEs) are responsible for Diabetes Mellitus. Hydroalcoholic extract of Whitton root (Eulophia nuda) was tested for in-vitro inhibition of non-enzymatic glycation of Immunoglobin G.  Plant extracts have their own importance and now being s...

Dinesh Prasad Yadav*, Ram Charan Chhipa and Balvinder Singh

Department of Biochemistry, Suresh Gyan Vihar University, Mahal Jagatpura, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3502-06

3502-3506

1440

654

87.

FORMULATION AND IN VITRO EVALUATION OF METOPROLOL SUCCINATE FLOATING TABLETS BY USING TWO VISCOSITY GRADE OF HPMC

Metoprolol is a beta1-selective (cardio selective) adrenergic receptor blocking agent used in the treatment of Hypertension. The purpose of this investigation is to improve bioavailability by preparing a gastroretentive drug delivery system. Floating tablets of Metoprolol Succinate were prepared by employing two different grades of HPMC K4M and HPMC E15M in different concentrations by effervescent...

Shubhrajit Mantry*, L.R. Thilothama and D. Shashanka

Department of pharmaceutics, Kottam Institute of Pharmacy, Mahaboobnagar Dist-509125, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3507-13

3507-3513

1685

452

88.

SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF CEFUROXIME SODIUM AND SULBACTAM SODIUM IN INJECTON

Cefuroxime is a 2nd-generation cephalosporin and Sulbactam is a β-Lactamase inhibitor. The combination formulation is used for the treatment of lower respiratory tract infection. Two new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Cefuroxime Sodium (CEF) and Sulbactam Sodium (SUL) in their combined dosage form...

F.M. Patel, J. B. Dave and C. N. Patel

Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3513-17

3513-3517

1482

1441

89.

AMELIORATIVE EFFECT OF HYGROPHILA AURICULATA (K. SCHUM) HEINE ON LIPID PEROXIDATION IN A RAT MODEL OF N-NITROSODIETHYLAMINE INDUCED HEPATOCELLULAR CARCINOMA

This study was designed to investigate the ameliorative effect effect of Hygrophila auriculata (H. auriculata) on lipid peroxidation (LPO) in N-nitrosodiethylamine induced Hepatocellular Carcinoma (HCC) in rats. Experimental rats were divided into different groups: normal, N-Nitrosodiethylamine induced hepatocellular Carcinoma bearing rats, H. auriculata treated hepatocellular carcinoma bearing ra...

S. Premkumari*and M.P. Balasubramanian

Department of Pharmacology, Sri Venkateswara Dental College, Thazhambur, Chennai-603 103, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3518-21

3518-3521

1334

560

90.

FORMULATION DEVELOPMENT OF BMP-NLC ENRICHED GEL

NLC are innovative vehicles introduced to overcome some limitations of SLN. Particularly, NLC, composed of a solid lipid and a certain content of liquid lipid (oil), show improved drug entrapment efficiency and an increased stability during storage with respect to SLN. Furthermore, NLC, maintaining their solid state, can control the API release from the matrix. To formulate Nanostructure lipid car...

Premanand A. Nighojkar , S. K. Uma Devi , Kiran V. Pund , Rajendra T. Gadakh and Manoj G. Shinde

Vel's College of Pharmacy, Velan Nagar, Pallavaram, Chennai - 600 117, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3522-29

3522-3529

2261

507